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Oxaliplatin

Oxaliplatin is a platinum-based antineoplastic agent used in the treatment of colorectal, ovarian, and other cancers.
It works by interfering with DNA synthesis, leading to cell death.
Oxaliplatin is often used in combination with other chemotherapeutic drugs and has been shown to improve survival outcomes in certain cancer types.
Researchers can use the PubCompare.ai tool to optimize their oxaliplatin studies, locating relevant protocols from literature, pre-prints, and patents, and leveraging AI-driven comparisons to identify the best approaches for their research.
This can enhance reproducibility and accuracy, key considerations when working with this potent antineoplastic agent.

Most cited protocols related to «Oxaliplatin»

1
Comprehensive CRC Cohort for Molecular Profiling
Cited 37 times
Fresh-frozen tumor specimens from 293 consecutive CRC patients were retrieved from the tissue banks of the Royal Melbourne Hospital, Western Hospital and Peter MacCallum Cancer Center in Australia, and the H. Lee Moffitt Cancer Center in the United States; individuals who had received preoperative chemo- and/or radiotherapy or for whom tumor-derived total RNA was inadequate for microarray analysis (RIN < 6) were excluded. All patients gave informed consent, and this study was approved by the medical ethics committees of all sites. Patient median age at diagnosis was 67 years (range 26 to 92 years). All specimens were derived from primary carcinomas and were snap-frozen in liquid nitrogen immediately after surgery for storage at −80°C. Cases comprised 44 stage A, 95 stage B, 93 stage C and 61 stage D cancers; 252 were localized to the colon and 40 to the rectum, with one case missing this information. 22 of 94 patients who had stage B disease and 64 of 91 patients who had stage C disease had received standard adjuvant chemotherapy (either single agent 5-fluouracil/capecitabine or 5-fluouracil and oxaliplatin) or postoperative concurrent chemoradiotherapy (50.4 Gy in 28 fractions with concurrent 5-fluorouracil) according to hospital protocols. All patients were assessed annually. For stage B and C patients, follow-up and additional clinical data including patient gender and TNM staging were collected by Biogrid Australia 1 for Australian patients and the Moffitt Cancer Center Tumor Registry for US patients. The median duration of follow-up was 47.8 months (range 0.9 to 118.6 months) for the 140 patients without recurrence, and 19.1 months (range 1.6 to 93.7 months) for the 48 patients with local or distant recurrence. The median follow-up for all 188 patients was 37.2 months (range 0.9 to 118.6 months).
Total RNA was extracted using Trizol reagent (Invitrogen) from CRC samples containing >60% tumor cells. All samples included showed good integrity of 18S and 28S ribosomal bands (RIN > 6) using a 2100 Bioanalyzer (Agilent Technologies). Total RNA was labeled and hybridized to HG-U133Plus2.0 GeneChip arrays (Affymetrix) according to the manufacturer’s instructions. The microarray data on a subset of 174 tumors have been published previously (NCBI Gene Expression Omnibus, GSE5206 and GSE13067).
In addition, published gene expression data were retrieved for 42 stage A CRCs, 83 stage B, 73 stage C and 62 stage D CRCs analyzed as part of the Expression Project for Oncology (expO) 2 using HG-U133Plus2.0 GeneChip arrays (Affymetrix) (Supplementary Table S1). Of the 62 stage D CRCs, 32 were primary cancer and 30 were metastectomy specimens. None of the primary cancer patients had received preoperative therapy, but 17 metastectomy specimens were from patients who had received adjuvant chemotherapy treatment prior to resection. Data processing and analysis were performed using the statistical software package R (15 ) and appropriate Bioconductor packages (16 (link)).
Jorissen R.N., Gibbs P., Christie M., Prakash S., Lipton L., Desai J., Kerr D., Aaltonen L.A., Arango D., Kruhøffer M., Ørntoft T.F., Andersen C.L., Gruidl M., Kamath V.P., Eschrich S., Yeatman T.J, & Sieber O.M. (2009). Metastasis-associated gene expression changes predict poor outcomes in patients with Dukes’ stage B and C colorectal cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 15(24), 7642-7651.
Publication 2009
Calcibiotic Root Canal Sealer Capecitabine Carcinoma Cells Chemotherapy, Adjuvant Colon Concurrent Chemoradiotherapy Diagnosis Ethics Committees Fluorouracil Freezing Gender Gene Chips Gene Expression Malignant Neoplasms Microarray Analysis Neoadjuvant Therapy Neoplasms Nitrogen Operative Surgical Procedures Oxaliplatin Patients Pharmaceutical Adjuvants Pharmacotherapy Radiotherapy Rectum Recurrence Ribosomes RNA, Neoplasm trizol
2
Cytotoxicity Assay of Anticancer Drugs
Cited 23 times
Cancer cells were first
counted, and approximately 4000 cells per well were seeded in a 96-well
cell culture plate (Corning Inc.). Then, after incubation at 37 °C
in a humidified atmosphere with 5% CO2 for 24 h, the culture
medium was replaced by a series of concentrations of drugs diluted
with the corresponding culture fluid. Five replicates were made for
each measurement, and the time of co-incubation was determined by
the efficiency of each drug. In this study, DOX (MedChemExpress Co.,
Ltd.) and CCM (Sinopharm Chemical Reagent Co., Ltd.) were co-incubated
with the cells for 24 h at 37 °C under the same conditions as
described above, whereas irinotecan hydrochloride injection (20 mg/mL,
Qilu Pharmaceutical), taxol (Aladdin), and oxaliplatin (Aladdin) were
co-incubated for 48 h. Finally, 10 μL of the CCK-8 reagent (MedChemExpress
Ltd.) was added into each well, and OD at 450 nm was measured using
a multifunction microplate reader (Infinite M200 Pro, Tecan) after
incubation for 2 h at 37 °C. The percentage each concentration
accounted for of the control was presented as cell viability. The
IC50 value was calculated using SPSS.
Cai L., Qin X., Xu Z., Song Y., Jiang H., Wu Y., Ruan H, & Chen J. (2019). Comparison of Cytotoxicity Evaluation of Anticancer Drugs between Real-Time Cell Analysis and CCK-8 Method. ACS Omega, 4(7), 12036-12042.
Publication 2019
Atmosphere Cell Survival Irinotecan Hydrochloride M-200 Malignant Neoplasms Oxaliplatin Pharmaceutical Preparations Sincalide Taxol
3
Systematic Evaluation of Chemotherapy Effects
Cited 17 times
Mouse body weight was determined at baseline, before each drug administration and every week up to 8 weeks. In addition, mice were also examined daily for evaluation of general health including observation for signs of hair loss, piloerection, general gait weakness, condition of the hind paws and tail skin, and gastrointestinal disorders.
Ear cavity temperature was measured using an infrared thermometer (model IRT303HACCP, National Product, MD) at baseline and after weeks 1, 3, 6, and 8 prior to performing the behavioral tests. Core body temperature was measured using a rectal probe (Thermalert TH-5 and TCAT-1A Controller, Physitemp Instruments, Inc) at baseline and after weeks 1, 3, and 6 in two mice from each drug treatment group after brief anesthesia with isoflurane.
The nephrotoxicity of cisplatin and oxaliplatin was assessed by blood urea nitrogen (BUN) levels in samples collected at the end of the 3-week drug treatment. Based on normal mouse BUN values (8–33 mg/dl according to normal reference laboratory values from Research Animal Resources at the University of Minnesota-; values as reported for normal untreated C57BL/6 mice [64 (link)]), BUN levels > 40 mg/dL were used as an indication of developing nephrotoxicity.
Ta L.E., Low P.A, & Windebank A.J. (2009). Mice with cisplatin and oxaliplatin-induced painful neuropathy develop distinct early responses to thermal stimuli. Molecular Pain, 5, 9.
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Publication 2009
Alopecia Anesthetics Behavior Test Body Temperature Body Weight Brief Treatment Cisplatin Debility Dental Caries Gastrointestinal Diseases Isoflurane Mice, Inbred C57BL Mus Oxaliplatin Pharmaceutical Preparations Piloerection Rectum Skin Tail Thermometers Urea Nitrogen, Blood
4
Organoid-based Pharmacotyping Assay
Cited 14 times
Organoids were dissociated into single cells. 500 viable cells were plated per well in in 20μL 10% Matrigel / human complete organoid media. Therapeutic compounds were added 24 hours post plating, after the reformation of organoids was visually verified. Chemotherapeutic were tested in triplicates: gemcitabine, paclitaxel, SN38 range from 8.1x10−12 M to 2.0x10−6 M, and 5-FU and Oxaliplatin range from 1.0x10−8 M to 5.0x10−5 M. Targeted drugs were tested in singlicates (range from 1.0x10−8 M to 1.0x10−5 M). Compounds were dissolved in DMSO and all treatment wells were normalized to 0.5% DMSO content. After 5 days cell viability was assessed using CellTiter-Glo as per manufacturer’s instruction (Promega) on a SpectraMax I3 (Molecular Devices) plate reader. A three-parameter log-logistic function with upper limit equal to the mean of the DMSO values was fit to the pharmacotyping data (viability vs. dose) with CRAN package drc v3.0-1 (61 (link)). Quality control was performed on the curve fitness: rejection of the curve if 100% plateau is located beyond 2 standard deviation of the mean DMSO control and visual inspection, leading to possible rejection, of the top 5% curves ranked with the highest sum of the squared differences between triplicate measurements and fitted curve. The area under the curve (AUC) was calculated using CRAN package Bolstad2 v1.0-28 (https://cran.r-project.org/web/packages/Bolstad2/). Normalized AUC was obtained by dividing the AUC value by the maximum area for the concentration range measured for each drug. The range of the normalized AUC is between 0 and 1.
Tiriac H., Belleau P., Engle D.D., Plenker D., Deschênes A., Somerville T.D., Froeling F.E., Burkhart R.A., Denroche R.E., Jang G.H., Miyabayashi K., Young C.M., Patel H., Ma M., LaComb J.F., Palmaira R.L., Javed A.A., Huynh J.C., Johnson M., Arora K., Robine N., Shah M., Sanghvi R., Goetz A.B., Lowder C.Y., Martello L., Driehuis E., LeComte N., Askan G., Iacobuzio-Donahue C.A., Clevers H., Wood L.D., Hruban R.H., Thompson E., Aguirre A.J., Wolpin B.M., Sasson A., Kim J., Wu M., Bucobo J.C., Allen P., Sejpal D.V., Nealon W., Sullivan J.D., Winter J.M., Gimotty P.A., Grem J.L., DiMaio D.J., Buscaglia J.M., Grandgenett P.M., Brody J.R., Hollingsworth M.A., O’Kane G.M., Notta F., Kim E., Crawford J.M., Devoe C., Ocean A., Wolfgang C.L., Yu K.H., Li E., Vakoc C.R., Hubert B., Fischer S.E., Wilson J.M., Moffitt R., Knox J., Krasnitz A., Gallinger S, & Tuveson D.A. (2018). Organoid profiling identifies common responders to chemotherapy in pancreatic cancer. Cancer discovery, 8(9), 1112-1129.
Publication 2018
Cells Cell Survival Drug Delivery Systems Gemcitabine Homo sapiens matrigel Medical Devices Organoids Oxaliplatin Paclitaxel Pharmaceutical Preparations Pharmacotherapy Promega Sulfoxide, Dimethyl
5
Quantifying Cell Viability and Chemoresponse
Cited 12 times
The MTT colorimetric assay, which measures metabolic activity of viable cells, was used to generate growth curves and determine the chemosensitivity of the cell lines.
First, growth curves were generated in duplicate to determine the optimal number of cells to use for the drug sensitivity assay. This was done to avoid growth inhibition due to seeding not enough cells or depletion of the medium after seeding too many cells. The highest number of cells showing continuing exponential growth after five days was selected for the drug response MTT assays (Table S1, File S1).
Response curves were generated for Carboplatin, Cisplatin, Oxaliplatin, Doxorubicin and 5-Fluorouracil (Intravenous solutions, Pharmachemie, The Netherlands), Paclitaxel (Intravenous solution, Ebewe Pharma, Austria), Docetaxel (dissolved in DMSO, Sigma), and Gemcitabin (for intravenous use, dissolved in PBS, Sun Pharmaceutical Industries Europe BV, The Netherlands). Cell viability was assessed in quadruplicate using the MTT assay after a five day exposure to 18 concentrations of the compound. Phoenix WinNonLin 1.1 software (Pharsight) was used to fit a dose response curve and to calculate the 50% growth inhibition values (GI50) with error and 95% confidence intervals (see also File S1).
Beaufort C.M., Helmijr J.C., Piskorz A.M., Hoogstraat M., Ruigrok-Ritstier K., Besselink N., Murtaza M., van IJcken W.F., Heine A.A., Smid M., Koudijs M.J., Brenton J.D., Berns E.M, & Helleman J. (2014). Ovarian Cancer Cell Line Panel (OCCP): Clinical Importance of In Vitro Morphological Subtypes. PLoS ONE, 9(9), e103988.
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Publication 2014
Biological Assay Carboplatin Cell Lines Cells Cell Survival Cisplatin Colorimetry compound 18 Docetaxel Doxorubicin Fluorouracil Gemcitabine Hypersensitivity Oxaliplatin Paclitaxel Pharmaceutical Preparations Psychological Inhibition Sulfoxide, Dimethyl

Most recents protocols related to «Oxaliplatin»

1
TRIM3 Modulation of CRC Xenograft Growth
To clarify the effect of TRIM3 in vivo, four-week-old male BALB/C nude mice purchased from the Institute of Zoology, at the Chinese Academy of Sciences of Shanghai were used to establish CRC xenografts. CRC cells (5 × 106) with TRIM3 overexpression were suspended in 100 μL of PBS and subcutaneously injected into flanks of the mice. To verify the chemosensitivity to oxaliplatin of TRIM3 overexpression in vivo, a single dose of 5 mg/kg oxaliplatin was injected via tail intravenous after 8 days of establishment xenograft models of TRIM3 overexpression. Tumor volume (mm3) was estimated weekly by using the following formula: tumor volume (mm3) = length × width2 × 0.5 [40 (link)]. All the mice were sacrificed after 4 weeks. All animal studies were performed in accordance with the animal care guidelines. All efforts were made to minimize animal suffering.
Han Y., Lu S., Song C., Xuan Y., Zhang M, & Cai H. (2023). Dual roles of TRIM3 in colorectal cancer by retaining p53 in the cytoplasm to decrease its nuclear expression. Cell Death Discovery, 9, 85.
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Publication 2023
Animals Cells Chinese Heterografts Males Mice, Inbred BALB C Mice, Laboratory Mice, Nude Oxaliplatin Tail
2
Oxaliplatin-Induced Pain Mitigation
After injection of oxaliplatin and the behavioral or calcium imaging baseline measurements (at least 3 h after injection), the mice were treated with either pregabalin (Sigma, Y0001805) at a dose of 2 mg/kg or vehicle (PBS) solutions via intravenous injection. Behavioral testing or calcium imaging were performed up to either 60 or 50 min after injection, respectively.
Iseppon F., Luiz A.P., Linley J.E, & Wood J.N. (2023). Pregabalin Silences Oxaliplatin-Activated Sensory Neurons to Relieve Cold Allodynia. eNeuro, 10(2), ENEURO.0395-22.2022.
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Publication 2023
Calcium, Dietary Mice, House Oxaliplatin Pregabalin
3
Pregabalin relieves oxaliplatin-induced cold allodynia
The data that support the findings of this study are openly available at: https://figshare.com/articles/dataset/Pregabalin_silences_oxaliplatin-activated_sensory_neurons_to_relieve_cold_allodynia/20200109.
Iseppon F., Luiz A.P., Linley J.E, & Wood J.N. (2023). Pregabalin Silences Oxaliplatin-Activated Sensory Neurons to Relieve Cold Allodynia. eNeuro, 10(2), ENEURO.0395-22.2022.
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Publication 2023
Allodynia Cold Temperature Oxaliplatin Pregabalin Sensory Receptor Cells
4
Oxaliplatin-Induced Neuropathy Mouse Model
Chemotherapy-induced neuropathy was studied in mice using the intraplantar Oxaliplatin model first described by Deuis and colleagues, because this treatment recapitulates the rapid onset of cold allodynia in human patients infused with the drug (Deuis et al., 2013 (link)). Oxaliplatin (Sigma, O9512) was dissolved in 5% glucose dH2O solution to an equivalent dose of 80 μg in 40 μl since Oxaliplatin is unstable in chloride-containing saline solution. Mice were treated by intraplantar injection into the left hindpaw. Behavioral testing or imaging was assessed at least 3 h after injection.
Iseppon F., Luiz A.P., Linley J.E, & Wood J.N. (2023). Pregabalin Silences Oxaliplatin-Activated Sensory Neurons to Relieve Cold Allodynia. eNeuro, 10(2), ENEURO.0395-22.2022.
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Publication 2023
Allodynia Chlorides Common Cold Glucose Homo sapiens Mus Oxaliplatin Patients Pharmaceutical Preparations Pharmacotherapy Saline Solution
5
Biomarkers of Oxidative Stress in Urine
Urine 1-hydroxypyrene (1-OHP) and malondialdehyde (MDA) (μg/g CRE): Spot urine samples were collected and sent to the central laboratory of the collaborating hospital for analysis. Urinary 1-OHP was analyzed using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and urinary MDA was quantified using standard thiobarbituric acid reactive substances (TBARS) assay. The urinary creatinine concentration was used for urinary 1-OHP and MDA adjustments (5 (link), 6 (link)).
Chang C.H., Weng H.H., Lin Y.C., Lin C.N., Huang T.J, & Chen M.Y. (2023). Association between serum carcinoembryonic antigen and cardiometabolic risks: Implication for cardiometabolic prevention. Frontiers in Endocrinology, 14, 1113178.
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Publication 2023
Biological Assay Creatinine Liquid Chromatography Malondialdehyde Oxaliplatin Tandem Mass Spectrometry Thiobarbituric Acid Reactive Substances Urine

Top products related to «Oxaliplatin»

1
Oxaliplatin by Merck Group
Sourced in United States, Germany, United Kingdom, Argentina, China, France, Macao, Australia, Austria, Belgium, Italy, Sweden
Oxaliplatin is a platinum-based chemotherapeutic agent used in the treatment of various types of cancer. It functions as a DNA crosslinking agent, disrupting cellular division and leading to cell death.
2
Fetal bovine serum (fbs) by Thermo Fisher Scientific
Sourced in United States, China, United Kingdom, Germany, Australia, Japan, Canada, Italy, France, Switzerland, New Zealand, Brazil, Belgium, India, Spain, Israel, Austria, Poland, Ireland, Sweden, Macao, Netherlands, Denmark, Cameroon, Singapore, Portugal, Argentina, Holy See (Vatican City State), Morocco, Uruguay, Mexico, Thailand, Sao Tome and Principe, Hungary, Panama, Hong Kong, Norway, United Arab Emirates, Czechia, Russian Federation, Chile, Moldova, Republic of, Gabon, Palestine, State of, Saudi Arabia, Senegal
Fetal Bovine Serum (FBS) is a cell culture supplement derived from the blood of bovine fetuses. FBS provides a source of proteins, growth factors, and other components that support the growth and maintenance of various cell types in in vitro cell culture applications.
3
Oxaliplatin by Selleck Chemicals
Sourced in United States, China, Germany
Oxaliplatin is a laboratory chemical product used in research and development applications. It functions as a platinum-based compound with medicinal and pharmaceutical applications.
4
Cisplatin by Merck Group
Sourced in United States, Germany, United Kingdom, China, Sao Tome and Principe, Macao, Italy, France, Canada, Japan, Spain, Czechia, Poland, Australia, India, Switzerland, Sweden, Belgium, Portugal
Cisplatin is a platinum-based medication used as a chemotherapeutic agent. It is a crystalline solid that can be dissolved in water or saline solution for administration. Cisplatin functions by interfering with DNA replication, leading to cell death in rapidly dividing cells.
5
Dimethyl sulfoxide (dmso) by Merck Group
Sourced in United States, Germany, United Kingdom, China, Italy, Sao Tome and Principe, France, Macao, India, Canada, Switzerland, Japan, Australia, Spain, Poland, Belgium, Brazil, Czechia, Portugal, Austria, Denmark, Israel, Sweden, Ireland, Hungary, Mexico, Netherlands, Singapore, Indonesia, Slovakia, Cameroon, Norway, Thailand, Chile, Finland, Malaysia, Latvia, New Zealand, Hong Kong, Pakistan, Uruguay, Bangladesh
DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.
6
Hct116 by American Type Culture Collection
Sourced in United States, China, Germany, United Kingdom, Japan, Australia, France, Israel, Spain, Poland, Italy
The HCT116 cell line is a human colorectal carcinoma cell line that is widely used in research. It is a commonly used model system for studying various aspects of cancer biology and drug development.
7
5 fluorouracil by Merck Group
Sourced in United States, Germany, China, United Kingdom, France, Canada, Japan, Sao Tome and Principe, Sweden, Poland
5-fluorouracil is a laboratory reagent used in scientific research. It is a pyrimidine analog that inhibits the enzyme thymidylate synthase, which is essential for DNA synthesis. 5-fluorouracil is commonly used in cell culture and molecular biology experiments to study cell growth and proliferation.
8
Dulbecco modified eagle medium (dmem) by Thermo Fisher Scientific
Sourced in United States, China, United Kingdom, Germany, France, Australia, Canada, Japan, Italy, Switzerland, Belgium, Austria, Spain, Israel, New Zealand, Ireland, Denmark, India, Poland, Sweden, Argentina, Netherlands, Brazil, Macao, Singapore, Sao Tome and Principe, Cameroon, Hong Kong, Portugal, Morocco, Hungary, Finland, Puerto Rico, Holy See (Vatican City State), Gabon, Bulgaria, Norway, Jamaica
DMEM (Dulbecco's Modified Eagle's Medium) is a cell culture medium formulated to support the growth and maintenance of a variety of cell types, including mammalian cells. It provides essential nutrients, amino acids, vitamins, and other components necessary for cell proliferation and survival in an in vitro environment.
9
Rpmi 1640 medium by Thermo Fisher Scientific
Sourced in United States, China, Germany, United Kingdom, Japan, France, Canada, Australia, Italy, Switzerland, Belgium, New Zealand, Spain, Israel, Sweden, Denmark, Macao, Brazil, Ireland, India, Austria, Netherlands, Holy See (Vatican City State), Poland, Norway, Cameroon, Hong Kong, Morocco, Singapore, Thailand, Argentina, Taiwan, Province of China, Palestine, State of, Finland, Colombia, United Arab Emirates
RPMI 1640 medium is a commonly used cell culture medium developed at Roswell Park Memorial Institute. It is a balanced salt solution that provides essential nutrients, vitamins, and amino acids to support the growth and maintenance of a variety of cell types in vitro.
10
Penicillin streptomycin by Thermo Fisher Scientific
Sourced in United States, Germany, United Kingdom, China, Canada, France, Japan, Australia, Switzerland, Israel, Italy, Belgium, Austria, Spain, Gabon, Ireland, New Zealand, Sweden, Netherlands, Denmark, Brazil, Macao, India, Singapore, Poland, Argentina, Cameroon, Uruguay, Morocco, Panama, Colombia, Holy See (Vatican City State), Hungary, Norway, Portugal, Mexico, Thailand, Palestine, State of, Finland, Moldova, Republic of, Jamaica, Czechia
Penicillin/streptomycin is a commonly used antibiotic solution for cell culture applications. It contains a combination of penicillin and streptomycin, which are broad-spectrum antibiotics that inhibit the growth of both Gram-positive and Gram-negative bacteria.

More about "Oxaliplatin"

Oxaliplatin is a potent platinum-based chemotherapeutic agent that has been widely used in the treatment of various cancers, including colorectal, ovarian, and other solid tumors.
This antineoplastic drug works by interfering with DNA synthesis, leading to cancer cell death.
Oxaliplatin is often used in combination with other chemotherapeutic agents, such as 5-fluorouracil (5-FU) and folinic acid, in a regimen known as FOLFOX, which has been shown to improve survival outcomes in certain cancer types.
Researchers can leverage the power of the PubCompare.ai tool to optimize their oxaliplatin-related studies.
This AI-driven platform allows researchers to locate relevant protocols from the scientific literature, preprints, and patents, and to compare these approaches in a systematic and data-driven manner.
By using PubCompare.ai, researchers can enhance the reproducibility and accuracy of their oxaliplatin studies, which is crucial when working with this potent antineoplastic agent.
When conducting oxaliplatin-based research, it is also important to consider the use of cell culture models, such as the HCT116 colorectal cancer cell line, and appropriate culture media, such as DMEM or RPMI 1640, supplemented with fetal bovine serum (FBS) and penicillin/streptomycin.
Researchers may also need to explore the use of other compounds, such as the platinum-based drug cisplatin or the solvent dimethyl sulfoxide (DMSO), in their experimental setups.
By leveraging the insights gained from the MeSH term description and the metadescription, and by incorporating relevant terms and concepts related to oxaliplatin, cell culture, and research tools, researchers can optimize their oxaliplatin-related studies and enhance the overall quality and impact of their work.