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Poloxamer 407

Poloxamer 407 is a non-ionic surfactant and triblock copolymer with unique thermoreversible gelation properties.
It has been widely studied for its potential applications in drug delivery, tissue engineering, and personal care products.
This versatile compound exhibits temperature-dependent solubility, forming viscous gels at physiological temperatures.
Researchers can leverage PubCompare.ai's innovative AI-driven platform to streamline their Poloxamer 407 projects, easily locating relevant protocols from literature, preprints, and patents, and leveraging powerful comparisons to identify the most effective products and procedures.
Optimie your Poloxamer 407 research process and take your projects to new heights with this cutting-edg solution.

Most cited protocols related to «Poloxamer 407»

1
In Vivo Evaluation of Lenvatinib's Anti-Tumor Effects
Cited 7 times
The animal experiments were approved by the Institutional Animal Care and Use Committee of The Fifth Medical Center (former name: The 302nd Hospital of Chinese PLA), General Hospital of Chinese People's Liberation Army (the ID of certification: IACUC‐2019‐001, Figure S1). All the animal studies were conducted in accordance with the UK Animals (Scientific Procedures) Act of 1986 and the associated guidelines. AML cells or MHCC97‐H cells were cultured and resuspended in physiological saline. Next, cell suspensions or cell suspensions containing 2% Poloxamer 407 were subcutaneously injected into nude mice. The concentration of cells in the cell suspension was 107 cells/mL. About 0.2 mL cell suspension per site was injected subcutaneously into nude mice at various sites. Three to four days’ after injection, the mice received 1, 0.5, 0.2 or 0.1 mg/kg lenvatinib by oral administration. The mice received lenvatinib treatment once per 2 days. After 10 treatments (about 20‐21 days), the mice were harvested and the volumes or weights of subcutaneous tumor tissues were examined. The tumor volumes of subcutaneous tumor tissues were calculated as tumor length × tumor width × tumor width/2.13, 14 The inhibition rates of lenvatinib on the subcutaneous growth of AML cells were calculated as [(control group tumor volumes)−(lenvatinib group tumor volumes)]/(control group tumor volumes) × 100%; [(control group tumor weights)−(lenvatinib group tumor weights)]/(control group tumor weights) × 100%.
Feng F., Li X., Li R, & Li B. (2019). The multiple‐kinase inhibitor lenvatinib inhibits the proliferation of acute myeloid leukemia cells. Animal Models and Experimental Medicine, 2(3), 178-184.
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Publication 2019
Administration, Oral Animals Cells Chinese Institutional Animal Care and Use Committees lenvatinib Mice, Nude Mus Neoplasms physiology Poloxamer 407 Psychological Inhibition Saline Solution Subcutaneous Tissue
2
Etodolac-Loaded Poloxamer 407 Nanomicelles
Cited 6 times
Etodolac was kindly gifted from European Egyptian Pharmaceutical Industries, Egypt and manufactured by Polpharma Pharmaceutical Works, Warsaw, Poland. Poloxamer 407 (Plx 407; Pluronic acid F127), phosphotungstic acid and MO were obtained from Sigma–Aldrich Chemie GmbH, Germany. Dialysis tubing cellulose membrane (molecular weight cutoff 12,000 g/mole) was purchased from Sigma Chemical Company (Sigma-Aldrich Corp., St. Louis, MO, USA). Poly(vinyl alcohol) (PVA; M.Wt. 22000 Da) was purchased from Sigma-Aldrich (Sigma-Aldrich Co., St. Louis, MO, USA). Potassium dihydrogen phosphate and disodium hydrogen phosphate were purchased from Sisco Research Laboratories Pvt. Ltd., Mumbai, India. HPLC grade of acetonitrile and methyl-t-butyl-ether were purchased from SDFCL – S. D. Fine Chemical Limited, Mumbai, India.
Salah S., Mahmoud A.A, & Kamel A.O. (2017). Etodolac transdermal cubosomes for the treatment of rheumatoid arthritis: ex vivo permeation and in vivo pharmacokinetic studies. Drug Delivery, 24(1), 846-856.
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Publication 2017
acetonitrile Acids Cellulose Dialysis Etodolac Europeans High-Performance Liquid Chromatographies methyl tert-butyl ether Moles Pharmaceutical Preparations Phosphotungstic Acid Pluronic F-127 Poloxamer 407 Polyvinyl Alcohol potassium phosphate, monobasic sodium phosphate, dibasic Tissue, Membrane
3
Brine Shrimp Bioassay for Cytotoxicity
Cited 4 times
Brine shrimp larvae were obtained by introducing the cysts of A. salina for 24–48 h, in a saline solution of 0,35%, under conditions of continuous light and aeration, at a temperature of 20 °C. After hatching brine shrimp in the first larval stage (instar I), they were separated and introduced into experimental pots (with a volume of 1 mL) in 0.3% saline solutions [13 (link)]. To obtain accurate results regarding the UBO cytotoxic effect, the analysis of the UBO emulsion was performed compared to the CNO one. A. salina larvae were not fed during the test, so as to not interfere with the tested extracts. This bioassay was valid for 24 h, during which the larvae had embryonic energy reserves as lipids.
Brine shrimp larvae were initially exposed to different UBO and CNO emulsions dilutions (emulsion: saline water) for 24 h (Table 11). As negative controls, the Poloxamer 407 aqueous solution 5% w/w concentration and saline aqueous solution 0.3% (pH > 7) were used.
After 24 h of exposure, the death rate (the larvae without visible movements in their experimental pots were considered dead) was the measurable parameter for quantifying larvae response to the various concentrations of CNO and UBO. These effects were also evaluated using microscopy with different magnifications and compared with negative controls.
The second step of the BSL assay consisted of lower dilutions preparation: 1:1, 1:2, 1:3, 1:4 from stock UBO and CNO emulsions in 0.3% saline aqueous solution (Figure S5, Supplementary Material). The brine shrimp larvae were exposed for only 6 h at these new dilutions; then, the cytotoxic effects were evaluated by counting the A. salina larvae without visible movements in their pots and examining with the microscope with different magnifications, for observing the presence or absence of fine movements (antennae and peristaltic movements) and morphological changes.
Popovici V., Bucur L., Gîrd C.E., Rambu D., Calcan S.I., Cucolea E.I., Costache T., Ungureanu-Iuga M., Oroian M., Mironeasa S., Schröder V., Ozon E.A., Lupuliasa D., Caraiane A, & Badea V. (2022). Antioxidant, Cytotoxic, and Rheological Properties of Canola Oil Extract of Usnea barbata (L.) Weber ex F.H. Wigg from Călimani Mountains, Romania. Plants, 11(7), 854.
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Publication 2022
Artemia Biological Assay Cyst Embryo Emulsions Larva Light Lipids Marijuana Abuse Microscopy Movement Peristalsis Poloxamer 407 Saline Solution Technique, Dilution
4
Heparin-based wound adhesive development
Cited 4 times
Poloxamer 407 was purchased from BASF (Shanghai, China). Triethylamine, 4-nitrophenyl chloroformate, 4-dimethylaminopyridine, 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC), and N-hydroxysuccinimide (NHS) were purchased from Aldrich Chemical Company (Shanghai, China). Low molecular weight heparin sodium salt (from porcine intestinal mucosa, 140 unit/mg) was supplied by Freda Biochem Company (Jinan, China). 2-octylcyanoacrylate was purchased from Beijing ShumKong Medical Company (Beijing, China). All other chemicals were used as received without further purification.
Japanese white rabbits (2-2.5 kg) were housed in an approved animal care center and were provided with standard chow and water ad libitum. The laboratory animal ethics committee and laboratory animal centre of Wenzhou Medical University approved all rabbit studies.
Zhao Y.Z., Lv H.F., Lu C.T., Chen L.J., Lin M., Zhang M., Jiang X., Shen X.T., Jin R.R., Cai J., Tian X.Q, & Wong H.L. (2013). Evaluation of a Novel Thermosensitive Heparin-Poloxamer Hydrogel for Improving Vascular Anastomosis Quality and Safety in a Rabbit Model. PLoS ONE, 8(8), e73178.
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Publication 2013
2-octyl cyanoacrylate 4-dimethylaminopyridine 4-nitrophenyl Animal Ethics Committees Animals Animals, Laboratory Carbodiimides Heparin, Low-Molecular-Weight Intestinal Mucosa Japanese N-hydroxysuccinimide Oryctolagus cuniculus Pigs Poloxamer 407 Rabbits Sodium Sodium Chloride triethylamine
5
CMC Determination of Poloxamer 407/TPGS Mixture
Cited 4 times
To determine the CMC of binary mixture of Poloxamer 407/TPGS in DI water, an ultraviolet-visible (UV-Vis) spectros-copy method was used, using iodine as a hydrophobic probe.30 (link) The KI/I2 standard solution was prepared by dissolving 0.5 g of iodine and 1 g of potassium iodide in 50 mL DI water. Samples of polymer solution with concentrations ranging from 0.00001% to 0.1% were prepared. To each of the Poloxamer 407/TPGS binary mixture (molar ratio 3:7) solutions, 25 μL KI/I2 standard solution was added. The mixtures were incubated for 12 hours in a dark room at room temperature before measurement. The ultraviolet absorbance value of varying polymer concentrations at 366 nm was measured using a UV-Vis spectrometer (DU 800; Beckman Coulter, Indianapolis, IN). Experiments were performed in triplicate. The absorption intensity was plotted against the logarithm of polymer concentration. The CMC values correspond to the concentration of the polymer at which the sharp increase in absorbance is observed.
Saxena V, & Hussain M.D. (2012). Poloxamer 407/TPGS mixed micelles for delivery of gambogic acid to breast and multidrug-resistant cancer. International Journal of Nanomedicine, 7, 713-721.
Publication 2012
Molar Poloxamer 407 Polymers tocophersolan

Most recents protocols related to «Poloxamer 407»

1
Tretinoin-Based Topical Gel Formulation
Not available on PMC !

Example 4

A composition comprising Tretinoin as active ingredient:

IngredientConcentration (w/w %)
Oleic acid5.00
Isopropanol10.00
BHT (Butylated Hydroxytoluene)0.02
Sorbic acid0.10
Tretinoin0.10
Silica microspheres0.70
CMC Na (carboxymethyl cellulose sodium)2.40
Natrosol (HBC)0.50
Glycerin5.00
Benzyl alcohol0.80
Poloxamer 4070.20
P. Waterq.s. 100%

The process for the preparation of the composition was as follows:

    • 1. CMC Na (carboxymethyl cellulose sodium) and Natrosol (HEC) were dispersed in water until a clear gel was formed
    • 2. Glycerin and benzyl alcohol were added to stage 1 and mixed;
    • 3. Oleic acid, isopropanol, BHT, sorbic acid, Poloxamer 407 and tretinoin were heated to 50° C. while stirring until clear solution was obtained. Then the solution was cooled to the room temperature;
    • 4. Silica Microspheres were added to the cooled oily phase and resultant mixture was stirred for at least one hour;
    • 5. Stage 4 was added to the stage 2 and stirred for one hour under vacuum.

An opaque yellowish gel was obtained.

US11865208B2. Pharmaceutical compositions comprising silica microspheres (2024-01-09). SOL-GEL TECHNOLOGIES LTD. [IL]. Inventors: Marina Shevachman [IL], Amira Ze' Evi [IL], Eilon Asculai [IL], Batella Benyaminovich [IL], Nir Avram [IL], Chaim Aschkenasy [IL].
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Patent 2024
Benzyl Alcohol Ethanol Glycerin Isopropyl Alcohol Microspheres Oils Oleic Acid Pharmaceutical Preparations Poloxamer 407 Silicon Dioxide Sodium Carboxymethylcellulose Sorbic Acid Tretinoin Vacuum
2
Tretinoin-Based Topical Gel Formulation
Not available on PMC !

Example 3

A composition comprising Tretinoin as active ingredient:

IngredientsConcentration (w/w %)
Oleic acid4.00
Isopropanol5.00
BHT (Butylated Hydroxytoluene)0.02
Sorbic acid0.10
Tretinoin0.10
Silica microspheres0.50-1.00
Poloxamer 407 A12.00-15.00
Poloxamer 407 B0.2-1.0
Benzyl alcohol0.80
Glycerin15.00 
Sodium hydroxide, dilutedAdjust pH
Waterq.s. 100%

The process for the preparation of the composition was as follows:

    • 1. Poloxamer 407 A was added to the water while stirring at high speed using mixer propeller;
    • 2. The mixture of oleic acid, isopropanol, BHT, sorbic acid, Poloxamer B and tretinoin was heated to 50° C. while stirring and then was cooled to the room temperature;
    • 3. Silica Microspheres were added to the stage 2 and resultant mixture was stirred for at least one hour;
    • 4. Benzyl alcohol and glycerin were added to stage 1 and stirred;
    • 5. Stage 3 was added to the mixer reactor and stirred vigorously;
    • 6. Sodium hydroxide was added for pH adjustment.

An opaque yellowish gel was obtained.

US11865208B2. Pharmaceutical compositions comprising silica microspheres (2024-01-09). SOL-GEL TECHNOLOGIES LTD. [IL]. Inventors: Marina Shevachman [IL], Amira Ze' Evi [IL], Eilon Asculai [IL], Batella Benyaminovich [IL], Nir Avram [IL], Chaim Aschkenasy [IL].
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Patent 2024
Benzyl Alcohol Ethanol Glycerin Isopropyl Alcohol Microspheres Oleic Acid Pharmaceutical Preparations Poloxamer Poloxamer 407 Silicon Dioxide Sodium Hydroxide Sorbic Acid Tretinoin
3
Humidity-Tolerant Adhesive Blends
Not available on PMC !

Example 3

The method of any one or more of Examples 1 through 2, wherein the humidity tolerant adhesive material comprises a blend of poloxamers.

Example 4

The method of Example 3, wherein the poloxamers are selected from the group consisting of: poloxamer 188; Synperonic® PE/P84; poloxamer 124; poloxamer 407; and combinations thereof.

US11877746B2. Surgical stapler buttress assembly with adhesion to wet end effector (2024-01-23). Cilag GmbH International [CH]. Inventors: Frederick E. Shelton, IV [US], Michael J. Vendely [US], Prudence A. Turner [US], Jackie J. Donners [US], Mark D. Timmer [US], Rao S. Bezwada [US], Aidan Craigwood [GB], Caroline Hagerman [GB], Ashley Easter [GB], Kathrin Holtzmann [GB].
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Patent 2024
Humidity Poloxamer Poloxamer 188 Poloxamer 407 Poloxamers
4
Synthesis of Thermosensitive PLGA-PEG-PEI Nanoparticles

Protocol full text hidden due to copyright restrictions

Open the protocol to access the free full text link

Publication 2023
Amphotericin B Bos taurus Carbodiimides Dialysis Emulsions glycolic acid Lactoferrin Methanol Methylene Chloride N-hydroxysuccinimide Poloxamer Poloxamer 407 poly(ethylene glycol)-co-poly(ethyleneimine) poly(ethylene imine) Poly A Polyethylene Glycols Polylactic Acid-Polyglycolic Acid Copolymer Polymers Solvents Tween 80 Ultrasonic Shockwave
5
Nasal Cast Delivery of Thermosensitive Gel
Cited 1 time
Each part of the nasal cast was coated with an artificial mucus based on a thermosensitive gel (liquid under 10°C and swells around 18°C) composed of 25% w/w of Poloxamer® 407 mixed into a simulated nasal electrolyte solution (SNES).47 (link),56 (link) We introduced an exact amount of around 20 mg of powder into the device since the maximal dose for nasal delivery is 25 mg per nostril.37 (link),57 (link) A previous study allowed us to determine the optimal parameters to target the olfactory zone.47 (link) The insertion angle was fixed with a direct aim of the olfactory zone (sagittal angle of 39° on the right and 29° on the left, and coronal angle of 20° on the right and 5° on the left, both pointing inwards). There was no concomitant inspiratory flow, and the powder was injected with a UDS device (Aptar Pharma, Le Vaudreuil, France). The device was weighed before and after the injection to evaluate the administered dose. After instillation, we washed each part of the nasal cast with a mixture of acetonitrile, ethanol, and MilliQ water (45:45:10% v/v). Each recovery solvent was quantified by an HPLC-UV method to determine the percentage of powder in each part. Here, since the target is N2B delivery, the analysis was focused on the olfactory deposition (i.e. the deposition in the uppermost piece of the middle region).
Deruyver L., Rigaut C., Gomez-Perez A., Lambert P., Haut B, & Goole J. (2023). In vitro Evaluation of Paliperidone Palmitate Loaded Cubosomes Effective for Nasal-to-Brain Delivery. International Journal of Nanomedicine, 18, 1085-1106.
Publication 2023
acetonitrile CD3EAP protein, human Electrolytes Ethanol High-Performance Liquid Chromatographies Inhalation Medical Devices Mucus Necrotizing encephalopathy, infantile subacute, of Leigh Nose Obstetric Delivery Poloxamer 407 Powder Sense of Smell Solvents

Top products related to «Poloxamer 407»

1
Poloxamer 407 by Merck Group
Sourced in United States, Germany, Italy, India, China, United Kingdom, Pakistan, Switzerland, France
Poloxamer 407 is a nonionic triblock copolymer composed of polyethylene oxide and polypropylene oxide segments. It is commonly used as a surfactant, emulsifier, and stabilizer in various pharmaceutical and laboratory applications.
2
Poloxamer 407 by BASF
Sourced in Germany, United States, India, United Kingdom
Poloxamer 407 is a non-ionic, water-soluble triblock copolymer. It is composed of a central hydrophobic block of polypropylene oxide (PPO) flanked by two hydrophilic blocks of polyethylene oxide (PEO). Poloxamer 407 is typically used in the formulation of various lab equipment and materials due to its unique physicochemical properties.
3
Tween 80 by Merck Group
Sourced in United States, Germany, United Kingdom, India, Italy, France, Sao Tome and Principe, Spain, Poland, China, Belgium, Brazil, Switzerland, Canada, Australia, Macao, Ireland, Chile, Pakistan, Japan, Denmark, Malaysia, Indonesia, Israel, Saudi Arabia, Thailand, Bangladesh, Croatia, Mexico, Portugal, Austria, Puerto Rico, Czechia
Tween 80 is a non-ionic surfactant and emulsifier. It is a viscous, yellow liquid that is commonly used in laboratory settings to solubilize and stabilize various compounds and formulations.
4
Fetal bovine serum (fbs) by Thermo Fisher Scientific
Sourced in United States, China, United Kingdom, Germany, Australia, Japan, Canada, Italy, France, Switzerland, New Zealand, Brazil, Belgium, India, Spain, Israel, Austria, Poland, Ireland, Sweden, Macao, Netherlands, Denmark, Cameroon, Singapore, Portugal, Argentina, Holy See (Vatican City State), Morocco, Uruguay, Mexico, Thailand, Sao Tome and Principe, Hungary, Panama, Hong Kong, Norway, United Arab Emirates, Czechia, Russian Federation, Chile, Moldova, Republic of, Gabon, Palestine, State of, Saudi Arabia, Senegal
Fetal Bovine Serum (FBS) is a cell culture supplement derived from the blood of bovine fetuses. FBS provides a source of proteins, growth factors, and other components that support the growth and maintenance of various cell types in in vitro cell culture applications.
5
Pluronic f 127 by Merck Group
Sourced in United States, Germany, United Kingdom, China, Italy, India, Spain, Switzerland, Sao Tome and Principe, France, Japan, Australia, Singapore, Macao, Brazil, Denmark, Austria
Pluronic F-127 is a non-ionic, tri-block copolymer composed of polyethylene oxide (PEO) and polypropylene oxide (PPO) segments. It is a widely used surfactant and emulsifying agent in various pharmaceutical and biomedical applications.
6
Poloxamer 188 by BASF
Sourced in Germany, India, China, United States, Spain
Poloxamer 188 is a nonionic, water-soluble block copolymer. It is commonly used as a surfactant, emulsifier, and dispersing agent in various laboratory and industrial applications.
7
Poloxamer 407 p407 by Merck Group
Sourced in United States, United Kingdom, Germany, Japan
Poloxamer 407 (P407) is a non-ionic triblock copolymer consisting of a central hydrophobic chain of polyoxypropylene (PPO) flanked by two hydrophilic chains of polyoxyethylene (PEO). It is a widely used pharmaceutical excipient that can function as a surfactant, emulsifier, and solubilizer.
8
Dimethyl sulfoxide (dmso) by Merck Group
Sourced in United States, Germany, United Kingdom, China, Italy, Sao Tome and Principe, France, Macao, India, Canada, Switzerland, Japan, Australia, Spain, Poland, Belgium, Brazil, Czechia, Portugal, Austria, Denmark, Israel, Sweden, Ireland, Hungary, Mexico, Netherlands, Singapore, Indonesia, Slovakia, Cameroon, Norway, Thailand, Chile, Finland, Malaysia, Latvia, New Zealand, Hong Kong, Pakistan, Uruguay, Bangladesh
DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.
9
Acetonitrile by Merck Group
Sourced in Germany, United States, Italy, India, China, United Kingdom, France, Poland, Spain, Switzerland, Australia, Canada, Brazil, Sao Tome and Principe, Ireland, Belgium, Macao, Japan, Singapore, Mexico, Austria, Czechia, Bulgaria, Hungary, Egypt, Denmark, Chile, Malaysia, Israel, Croatia, Portugal, New Zealand, Romania, Norway, Sweden, Indonesia
Acetonitrile is a colorless, volatile, flammable liquid. It is a commonly used solvent in various analytical and chemical applications, including liquid chromatography, gas chromatography, and other laboratory procedures. Acetonitrile is known for its high polarity and ability to dissolve a wide range of organic compounds.
10
Sodium chloride (nacl) by Merck Group
Sourced in United States, Germany, United Kingdom, India, Italy, France, Spain, China, Canada, Sao Tome and Principe, Poland, Belgium, Australia, Switzerland, Macao, Denmark, Ireland, Brazil, Japan, Hungary, Sweden, Netherlands, Czechia, Portugal, Israel, Singapore, Norway, Cameroon, Malaysia, Greece, Austria, Chile, Indonesia
NaCl is a chemical compound commonly known as sodium chloride. It is a white, crystalline solid that is widely used in various industries, including pharmaceutical and laboratory settings. NaCl's core function is to serve as a basic, inorganic salt that can be used for a variety of applications in the lab environment.

More about "Poloxamer 407"

Poloxamer 407, also known as Pluronic F-127 or Poloxamer P407, is a non-ionic triblock copolymer composed of polyethylene oxide (PEO) and polypropylene oxide (PPO) segments.
This versatile compound has garnered significant attention for its unique thermoreversible gelation properties, making it a popular choice in drug delivery, tissue engineering, and personal care applications.
Poloxamer 407 exhibits temperature-dependent solubility, forming viscous gels at physiological temperatures, which can be leveraged to improve the bioavailability and controlled release of various pharmaceutical and cosmetic ingredients.
Researchers often combine Poloxamer 407 with other excipients, such as Tween 80, FBS, Pluronic F-127, Poloxamer 188, DMSO, and Acetonitrile, to optimize its performance and tailor the formulation to specific needs.
To streamline Poloxamer 407 research, researchers can utilize PubCompare.ai's innovative AI-driven platform.
This cutting-edge solution allows users to easily locate relevant protocols from literature, preprints, and patents, and leverage powerful comparisons to identify the most effective products and procedures.
By optimizing the research process, researchers can take their Poloxamer 407 projects to new heights and enhance the reproducibility of their findings.
Whether you're working on drug delivery systems, tissue engineering constructs, or personal care formulations, PubCompare.ai's AI-powered platform can help you navigate the vast landscape of Poloxamer 407 research and unlock new possibilities for your projects.
Embrace this innovative solution and elevtate your Poloxamer 407 research to new levels of efficiency and success.