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Prazosin

Prazosin is an alpha-1 adrenergic receptor antagonist used to treat hypertension, benign prostatic hyperplasia, and other conditions.
It works by blocking the action of norepinephrine, leading to vasodilation and reduced peripheral resistance.
Prazosin research is crucial for understanding its pharmacology, therapeutic applications, and potential side effects.
PubCompare.ai's AI-driven platform can help researchers optimize their Prazosin studies by locating the best protocols from literature, pre-prints, and patents, while ensuring reproducible and accurate findings.
This innovative tool can streamlin Prazosin research and accelerate the development of new treatment strategies.

Most cited protocols related to «Prazosin»

1
ABCG2 Transfection in HEK-293 Cells
Cited 58 times
HEK-293 cells were transfected with either empty pcDNA3 vector (Invitrogen, Carlsbad, CA, USA) or pcDNA3 vector containing full-length ABCG2 coding either an arginine, threonine or glycine for amino-acid 482. Expression of ABCG2 in the transfectants was enforced by selection in G418 (Invitrogen, Carlsbad, CA, USA). Stable transfectants were maintained in Eagle's minimum essential medium (ATCC, Manassas, VA, USA) supplemented with 10% FCS, penicillin, and streptomycin with G418 at a concentration of 2 mg ml−1. Clones were preliminarily screened for ABCG2 expression by examining the ability of the cells to efflux BODIPY-prazosin in a flow cytometry-based assay. The ABCG2 sequence was subsequently verified in the clones examined here.
Robey R.W., Honjo Y., Morisaki K., Nadjem T.A., Runge S., Risbood M., Poruchynsky M.S, & Bates S.E. (2003). Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity. British Journal of Cancer, 89(10), 1971-1978.
Publication 2003
Amino Acids antibiotic G 418 Arginine Biological Assay BODIPY Clone Cells Cloning Vectors Flow Cytometry Glycine HEK293 Cells Penicillins Prazosin Streptomycin Threonine
2
Pharmacological Preparation and Administration
Cited 14 times
Clozapine was provided as a generous gift to J.H.P. from Novartis (Hanover, NJ, USA). Olanzapine was provided as a generous gift to J.H.P. from Eli Lilly (Indianapolis, IN, USA). Clozapine, olanzapine, and risperidone were supplied to D.W. by the National Institute of Mental Health’s Chemical Synthesis and Drug Supply Program. Haloperidol, prazosin, propranolol, and ritanserin were purchased from Sigma-Aldrich (St. Louis, MO, USA). J.H.P. and M.S.F. obtained CNO from the Rapid Access to Investigative Drug Program funded by the National Institute of Neurological Disorders and Stroke. D.W. obtained CNO from the National Institute on Drug Abuse Drug Supply Program.
Clozapine, olanzapine, risperidone, haloperidol, prazosin, propranolol, and ritanserin were each dissolved in distilled water with 2–3 drops of lactic acid and pH-adjusted to 6.0–7.0 with NaOH. For mouse drug discrimination studies, CNO was also dissolved in this vehicle. For rat drug discrimination studies and for mouse and rat pharmacokinetic analyses, CNO was dissolved in bacteriostatic saline containing v/v 2.5–5.0% dimethyl sulfoxide (Sigma-Aldrich) and 10% Cremophor EL (Sigma-Aldrich).
For mouse drug discrimination studies, all drugs were administered s.c. at a volume of 10 ml/kg, 30 min prior to session onset. For rat drug discrimination studies, all drugs were administered i.p. at a volume of 1 ml/kg. Clozapine was administered 60 min prior to session onset, while olanzapine, risperidone, prazosin, and propranolol were administered 30 min prior to session onset. CNO was tested at both 30 and 60 min pretreatment times. All drug doses are expressed as the salt weight.
Manvich D.F., Webster K.A., Foster S.L., Farrell M.S., Ritchie J.C., Porter J.H, & Weinshenker D. (2018). The DREADD agonist clozapine N-oxide (CNO) is reverse-metabolized to clozapine and produces clozapine-like interoceptive stimulus effects in rats and mice. Scientific Reports, 8, 3840.
Publication 2018
Anabolism Clozapine cremophor EL Discrimination, Psychology Haloperidol Lactic Acid Mice, House Olanzapine Pharmaceutical Preparations Prazosin Propranolol Risperidone Ritanserin Saline Solution Sodium Chloride Sulfoxide, Dimethyl
3
Comprehensive Assessment of Traumatic Injury
Cited 13 times
The nine-item Patient Health Questionnaire (PHQ)41 (link) was used to assess depressive symptoms. The Alcohol Use Disorders Identification Test-Consumption Items (AUDIT-C)42 were used to assess alcohol use. The Medical Outcomes Study Short Form 36 (MOS SF-36) Physical Component Summary (PCS)43 score was used to assess physical health and function. Prior trauma, PTSD symptoms, and pre-injury alcohol abuse/dependence were assessed with items from the National Co-morbidity Survey investigations.44 (link) Previously developed items assessing post-injury health service use were administered at the baseline and at the one-, three-, six-, nine-, and twelve-month follow-up interviews.33 (link) Interview items contained self-report descriptions of current medication usage (i.e., name, dosage, duration). We derived from these items the number of anti-depressant prescriptions, attainment of guideline dosages, and adequate adherence to guideline level doses for ≥ 25 or more days. Other medication categories included medications targeting insomnia related to PTSD (i.e., prazosin or trazadone). The number of psychotherapy visits was also assessed at each follow-up time point. Finally, items assessing satisfaction with general health care services and emotional health care services were included in all interviews.33 (link)The investigation determined injury severity at baseline during the index admission from the medical record International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) Codes using the Abbreviated Injury Scale and Injury Severity Score.45 TBI was also prospectively identified in the medical record and categorized by the following ICD-9-CM codes: 800.0–801.9, 803.0–804.9, 850.0–854.1, and 959.01.8 (link), 46 (link) TBI severity was coded based on a previously validated algorithm for hospitalized inpatients.8 (link), 46 (link) Laboratory toxicology results, insurance status, length of hospital and intensive care unit stays, and other clinical characteristics were abstracted from the trauma registry and electronic medical record.
Zatzick D., Jurkovich G., Rivara F.P., Russo J., Wagner A., Wang J., Dunn C., Lord S.P., Petrie M., O’Connor S.S, & Katon W. (2013). A Randomized Stepped Care Intervention Trial Targeting Posttraumatic Stress Disorder for Surgically Hospitalized Injury Survivors. Annals of surgery, 257(3), 390-399.
Publication 2013
6-pyruvoyl-tetrahydropterin synthase deficiency Abuse, Alcohol Alcoholic Intoxication, Chronic Alcohol Use Disorder Depressive Symptoms Drug Abuse Emotions Injuries Inpatient Pharmaceutical Preparations Physical Examination Prazosin Prescriptions Psychotherapy Satisfaction Sleeplessness Wounds and Injuries
4
Prazosin Administration in Alcohol-Preferring Rats
Cited 7 times
Prazosin, expressed as free base mass (Fluka Chemical Corp., Milwaukee, WI), was dissolved in deionized, distilled water containing 3 g dextrose (Sigma-Aldrich, St. Louis, MO) and 125 mg sodium saccharin (Sigma-Aldrich, St. Louis, MO) per 100 ml water. Berry-flavored Jell-O (21.0 g/100 ml) and Knox gelatin (18.0 g/100 ml) were added to the solution, heated, and the solution containing drug or no drug (vehicle) was aliquoted into molds to form star-shaped pieces of gelatin, one per rat per day, with the volume of each aliquot determined by body weight of the rat to produce doses of 0, 0.5, 1.0, or 2.0 mg prazosin/3.0 ml solution/kg BW. The gelatin (approximately 1.8 g), with or without prazosin, was fed to the rats once each day at 45 minutes prior to the 2hr alcohol access period. The rats grabbed the gelatin and consumed it within 1 minute. Cages were checked to ensure that no pieces were dropped, which they seldom were. In an earlier study (data not shown), consumption of gelatin without drug (vehicle) at 45 min prior to 2 hr alcohol access did not alter alcohol intake. Specifically, average daily 2 hr alcohol intake during the 5 days prior to consumption of vehicle gelatin pieces was 1.8 g/kg BW (N=64 adult male P rats) and average daily 2 hr alcohol intake in these same rats during 5 days of vehicle gelatin consumption was 1.7 g/kg BW. To familiarize the rats in the current study with the gelatin, vehicle gelatin pieces were fed to the rats once/day for one week prior to initiation of drug treatment. Feeding drug in flavored gelatin is an approach we previously used successfully for the prolonged administration of prazosin in rats (Froehlich et al., 2010 ). This method of drug delivery is optimal for long-term treatment and can be used with drugs that are orally active such as naltrexone, prazosin, or buprenorphine (Froehlich et al., 2010 ; Liles et al., 1997). Prazosin is well-absorbed after oral administration and its bioavailability is high (about 70%) (Goodman and Gilman, 2006 ), so doses that are effective when administered via non-oral routes are also effective orally. The doses of prazosin used in the current study are those that we previously found to be effective in reducing alcohol drinking in P rats when administered intraperitoneally (Rasmussen et al., 2009a (link)).
Froehlich J.C., Hausauer B.J., Federoff D.L., Fischer S.M, & Rasmussen D.D. (2013). PRAZOSIN REDUCES ALCOHOL DRINKING THROUGHOUT PROLONGED TREATMENT AND BLOCKS THE INITIATION OF DRINKING IN RATS SELECTIVELY BRED FOR HIGH ALCOHOL INTAKE. Alcoholism, clinical and experimental research, 37(9), 1552-1560.
Publication 2013
Administration, Oral Adult Berries Body Weight Buprenorphine Drug Delivery Systems Ethanol Fungus, Filamentous Gelatins Gels Glucose Long-Term Care Males Naltrexone Pharmaceutical Preparations Prazosin Rattus Saccharin Sodium
5
Alcohol Access Reduction in Rats
Cited 7 times
All rats were initially provided with 24-hour access to food, water and 15% (v/v) alcohol for three weeks. Fluid intakes and body weights were recorded every other day. Access to alcohol was then reduced to daily scheduled access times using a “step down” procedure. Twenty four hour access to alcohol was first reduced from seven days/week to five days/week (Monday–Friday) for one week. Then 24-hour access to alcohol was reduced to four hours/day for five days/week for two weeks and then to two hours/day for five days/week for the remainder of the experiment. Alcohol was available from 1100 h (one hour after lights off) to 1300 h, five days/week for seven weeks prior to administration of prazosin. All rats were always given ad libitum access to food and water. Alcohol intake, water intake and body weight were recorded daily.
Rasmussen D.D., Alexander L.L., Raskind M.A, & Froehlich J.C. (2008). THE α1-ADRENERGIC RECEPTOR ANTAGONIST, PRAZOSIN, REDUCES ALCOHOL DRINKING IN ALCOHOL-PREFERRING (P) RATS. Alcoholism, clinical and experimental research, 33(2), 264-272.
Publication 2008
Body Weight Ethanol Food Light Prazosin Rattus norvegicus Water Consumption

Most recents protocols related to «Prazosin»

1
Brexanolone Treatment for Postpartum Depression

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Open the protocol to access the free full text link

Publication 2023
Adrenergic alpha-Antagonists Adrenergic beta-Antagonists Anti-Anxiety Agents Antiepileptic Agents Antipsychotic Agents Anxiety Aripiprazole Ativan Benadryl Benzodiazepines brexanolone Buspar Care, Ambulatory Clonazepam Depression, Postpartum Desvenlafaxine Dopamine Uptake Inhibitors Duloxetine Escitalopram Ethics Committees, Research Ethnicity Fluoxetine Hispanics Histamine H1 Antagonists Lithium Lurasidone Mood Norepinephrine Obstetric Delivery Olanzapine Patients Post-Traumatic Stress Disorder Prazosin Pregabalin Propranolol Psychotropic Drugs Quetiapine Selective Serotonin Reuptake Inhibitors Serotonin Uptake Inhibitors Sertraline SNRIs Trazodone Treatment Protocols Vistaril Wellbutrin Woman
2
Vasodilator Pharmacology Protocols
(R)-(-)-Phenylephrine hydrochloride, prazosin hydrochloride, nifedipine, chelerythrine, and cromakalim were purchased from Sigma-Aldrich (St. Louis, MO, USA), propranolol hydrochloride, and amphotericin B were purchased from FUJIFILM Wako Pure Chemical Corporation (Osaka, Japan). nifedipine, prazosin, chelerythrine, and cromakalim were dissolved in dimethyl sulfoxide. Small aliquots were added to the extracellular solution to obtain the desired final concentration. The other chemicals were dissolved in distilled water. All other chemicals were commercial products of the highest available quality.
Hamaguchi S., Morinou I., Shiseki Y., Mikami A., Seki M., Namekata I, & Tanaka H. (2023). Mechanisms for the α-Adrenoceptor-Mediated Positive Inotropy in Mouse Ventricular Myocardium: Enhancing Effect of Action Potential Prolongation. International Journal of Molecular Sciences, 24(4), 3926.
Publication 2023
Amphotericin B chelerythrine Cromakalim Nifedipine Phenylephrine Phenylephrine Hydrochloride Prazosin Prazosin Hydrochloride Propranolol Hydrochloride Sulfoxide, Dimethyl
3
Pharmacological Modulation of Energy Metabolism
Roflumilast(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide, MW = 403 g/mol; 1 mg/kg ≈ 2.5 µmol/kg), rolipram (4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one; MW = 275 g/mol; 1 mg/kg ≈ 3.6 µmol/kg), piclamilast (RP73401; 3-(Cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide; MW = 381 g/mol; 1 mg/kg ≈ 2.6 µmol/kg), prazosin ([4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone, monohydrochloride; MW = 420 g/mol; 1 mg/kg ≈ 2.4 µmol/kg), clonidine (N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine, monohydrochloride; MW = 267 g/mol; 1 mg/kg ≈ 3.7 µmol/kg), yohimbine (17α-hydroxy-yohimban-16α-carboxylic acid, methyl ester, monohydrochloride, MW = 391 g/mol; 1 mg/kg ≈ 2.6 µmol/kg), and diazoxide (7-chloro-3-methyl-1,1-dioxide-2H-1,2,4-benzothiadiazine; MW = 231 g/mol; 1 mg/kg ≈ 4.3 µmol/kg) were sourced from Cayman Chemical (Ann Arbor, MI), isoprenaline/isoproterenol (4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol, monohydrochloride; MW = 248 g/mol; 1 mg/kg ≈ 4 µmol/kg) and propranolol (1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol, monohydrochloride; MW = 296 g/mol; 1 mg/kg ≈ 3.4 µmol/kg) were obtained from Millipore Sigma (St. Louis, MO, USA), and RS25344 (1-(3-nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4-dione, monohydrochloride; MW = 412 g/mol; 1 mg/kg ≈ 2.4 µmol/kg) was obtained from Santa Cruz Biotech (Santa Cruz, CA, USA). All drugs were initially dissolved in dimethyl sulfoxide (DMSO), subsequently diluted with phosphate-buffered saline (PBS) at a pH of 7.4, containing final concentrations of 5% DMSO and 5% Cremophor EL (Millipore Sigma, St. Louis, MO), and were applied by intraperitoneal (i.p.) injection (100 µL per 20 g body weight). The D-glucose was obtained from Fisher Chemical (Waltham, MA, USA), and insulin (Humulin R U-100) from Lilly USA (Indianapolis, IN, USA).
Irelan D., Boyd A., Fiedler E., Lochmaier P., McDonough W., Aragon I.V., Rachek L., Abou Saleh L, & Richter W. (2023). Acute PDE4 Inhibition Induces a Transient Increase in Blood Glucose in Mice. International Journal of Molecular Sciences, 24(4), 3260.
Publication 2023
Amines benzamide Body Weight Caimans Clonidine cremophor EL Diazoxide Esters ethylbenzene furan Glucose Humulin S Hydroxy Acids Imidazoles Insulin Isoproterenol Pharmaceutical Preparations Phosphates piclamilast Piperazine Prazosin Propranolol Pyrimidines Roflumilast Rolipram Saline Solution Sulfoxide, Dimethyl Yohimbans Yohimbine
4
Investigating the Mechanisms of iROE Analgesia
The effects of iROE on mechanical hyperalgesia caused by plantar incision were further investigated to ascertain whether they were involved in α1 and α2 adrenergic, cholinergic (nicotinic and muscarinic), and opioid receptors. Forty-two rats were randomly allocated to seven groups (n = six rats per group), including one iROE group that served as a control and the other six groups that included rats that were given iROE and study drugs (yohimbine 2 mg/kg, dexmedetomidine 50 μg/kg, prazosin 1 mg/kg, atropine 5 mg/kg, mecamylamine 1 mg/kg, and naloxone 5 mg/kg). Two hours after the plantar incisions, normal saline or study drugs were administered intraperitoneally. After 10 min, 300 mg/kg iROE was administered intraperitoneally. Previous study suggested the application of drugs to investigate the possible involvement of the aforementioned receptor systems [9 (link),15 (link),16 (link),17 (link),18 (link)]. All study drugs were provided by Sigma-Aldrich.
Choi G.J., Kang H., Lee O.H, & Kwon J.W. (2023). Effect of Immature Rubus occidentalis on Postoperative Pain in a Rat Model. Medicina, 59(2), 264.
Publication 2023
Adrenergic Agents Atropine Cholinergic Agents Dexmedetomidine Mecamylamine Mechanical Allodynia Muscarinic Agents Naloxone Nicotine Normal Saline Opioid Receptor Pharmaceutical Preparations Prazosin Rattus norvegicus Yohimbine
5
Preoperative Management of Pheochromocytoma
The preoperative diagnoses were based on laboratory tests and diagnostic imaging. For patients who present typical biochemical manifestations of pheochromocytoma, α adrenoreceptor antagonists (doxazosin, terazosin, or prazosin) were conventionally used at least two weeks before the operation. Intravenous crystalloid or colloid fluid were admitted for volume expansion about three days before the operation. The criteria for preoperative medical preparation success included a blood pressure < 130/80 mmHg, a heart rate < 90/min, and a hematocrit < 0.45.
Ge Y., Zhan Y., Pan C., Li J., Li Z., Bai S, & Liu L. (2023). Development and Validation of a Nomogram for Predicting Blood Pressure Change Failure in Patients with Pheochromocytoma and Concomitant Hypertension after Adrenalectomy. Journal of Clinical Medicine, 12(3), 874.
Publication 2023
Adrenergic Antagonists alpha-Adrenergic Receptor antagonists Blood Pressure Colloids Diagnosis Doxazosin Patients Pheochromocytoma Prazosin Rate, Heart Solutions, Crystalloid Surgery, Day Terazosin Volumes, Packed Erythrocyte

Top products related to «Prazosin»

1
Prazosin by Merck Group
Sourced in United States, France, Germany, Switzerland, United Kingdom, Australia
Prazosin is a laboratory equipment product manufactured by Merck Group. It is a chemical compound used in research and scientific applications. Prazosin is primarily used as a standard reference material and a research tool in various scientific fields.
2
Propranolol by Merck Group
Sourced in United States, Germany, United Kingdom, China, France, Macao, Sao Tome and Principe, Spain
Propranolol is a laboratory reagent used as a β-adrenergic receptor antagonist. It is commonly used in research applications to study the role of the sympathetic nervous system.
3
Yohimbine by Merck Group
Sourced in United States, Germany, United Kingdom, Canada, Italy
Yohimbine is a laboratory compound utilized in various scientific research applications. It functions as an alpha-2 adrenergic receptor antagonist, inhibiting the activity of these receptors. This compound is widely used in the field of pharmacology and neuroscience for research purposes.
4
Dimethyl sulfoxide (dmso) by Merck Group
Sourced in United States, Germany, United Kingdom, China, Italy, Sao Tome and Principe, France, Macao, India, Canada, Switzerland, Japan, Australia, Spain, Poland, Belgium, Brazil, Czechia, Portugal, Austria, Denmark, Israel, Sweden, Ireland, Hungary, Mexico, Netherlands, Singapore, Indonesia, Slovakia, Cameroon, Norway, Thailand, Chile, Finland, Malaysia, Latvia, New Zealand, Hong Kong, Pakistan, Uruguay, Bangladesh
DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.
5
Prazosin hydrochloride by Merck Group
Sourced in United States, France
Prazosin hydrochloride is a chemical compound used as a laboratory reagent. It is a crystalline solid that is soluble in water and other polar solvents. Prazosin hydrochloride is commonly used in research applications, but its specific core function is not provided in order to maintain an unbiased and factual approach.
6
3h prazosin by PerkinElmer
Sourced in Italy, United States
[3H]prazosin is a radiolabeled compound used in research applications. It is a selective alpha-1 adrenergic receptor antagonist. This product is intended for use in in vitro and in vivo laboratory research applications.
7
Prazosin by Bio-Techne
Sourced in United Kingdom
Prazosin is a laboratory product manufactured by Bio-Techne. It is a selective antagonist of the alpha-1 adrenergic receptor. Prazosin is used in research applications to study adrenergic receptor function and signaling pathways.
8
Ketanserin by Merck Group
Sourced in United States, Germany, United Kingdom
Ketanserin is a serotonin 2A (5-HT2A) receptor antagonist used as a laboratory research tool. It has a high affinity for 5-HT2A receptors and is commonly used in experimental studies to investigate the role of serotonin signaling in various biological processes.
9
Phentolamine by Merck Group
Sourced in United States, Spain, United Kingdom, Sao Tome and Principe
Phentolamine is a laboratory chemical used as a research tool. It functions as an alpha-adrenergic antagonist, which means it blocks the effects of certain hormones in the body. This product is intended for research and laboratory use only, and its specific applications are dependent on the research objectives.
10
Sch23390 by Bio-Techne
Sourced in United Kingdom, United States
SCH23390 is a selective dopamine D1 receptor antagonist. It binds to the D1 dopamine receptor with high affinity and selectivity, making it a useful tool for studying the function and distribution of this receptor subtype.

More about "Prazosin"

Prazosin is an alpha-1 adrenergic receptor antagonist used to treat a variety of conditions, including hypertension, benign prostatic hyperplasia, and other disorders.
It works by blocking the action of the neurotransmitter norepinephrine, leading to vasodilation and reduced peripheral resistance.
Prazosin research is crucial for understanding its pharmacology, therapeutic applications, and potential side effects.
Researchers can optimize their Prazosin studies using PubCompare.ai's AI-driven platform, which helps locate the best protocols from scientific literature, pre-prints, and patents.
This innovative tool ensures reproducible and accurate findings by performing intelligent comparisons across data sources.
By streamlining the research process, PubCompare.ai can accelerate the development of new treatment strategies for conditions related to Prazosin, such as high blood pressure, enlarged prostate, and other conditions.
In addition to Prazosin, researchers may also be interested in studying related compounds like Propranolol (a beta-blocker), Yohimbine (an alpha-2 adrenergic receptor antagonist), and DMSO (a solvent often used in Prazosin studies).
Understanding the pharmacology and interactions of these substances can provide valuable insights for Prazosin research.
Additionally, the use of Prazosin hydrochloride, [3H]prazosin (a radiolabeled form of the drug), Ketanserin (a serotonin antagonist), and Phentolamine (an alpha-adrenergic receptor antagonist) may be relevant in Prazosin-related studies.
Optimizing Prazosin research with PubCompare.ai's AI-powered platform can help researchers achieve more reproducible and accurate findings, ultimately accelerating the development of new treatment strategies for a variety of medical conditions.