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Propargyl bromide

Propargyl bromide is a chemical compound used in various applications, including organic synthesis and materials science.
It is a highly reactive species that can undergo a variety of reactions, making it a valuable precursor for the preparation of other compounds.
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Most cited protocols related to «Propargyl bromide»

1
Synthesis and Characterization of Sugar Derivatives
Cited 6 times
NMR spectra were recorded with an Agilent spectrometer at a frequency of 400 MHz using TMS or DSS as the internal standards and CDCl3, CD3OD, DMSO-d6 or D2O as the solvents. NMR solvents were purchased from ACROS Organics (Geel, Belgium). Chemical shifts (δ) are expressed in ppm and coupling constants (J) in Hz. The following abbreviations were used to explain the observed multiplicities: s: singlet, d: doublet, dd: doublet of doublets, ddd: doublet of doublet of doublets, t: triplet, dd-t: doublet of doublets resembling a triplet (with similar values of coupling constants), m: multiplet, p: pentet (quintet), b: broad. High-resolution mass spectra (HRMS) were recorded with a WATERS LCT Premier XE system using the electrospray-ionization (ESI) technique. Optical rotations were measured with a JASCO P-2000 polarimeter using a sodium lamp (589.3 nm) at room temperature. Melting point measurements were performed on OptiMelt (MPA 100) Stanford Research Systems. Reactions were monitored by thin-layer chromatography (TLC) on precoated plates of silica gel 60 F254 (Merck Millipore, Burlington, MA, USA). The TLC plates were visualized under UV light (λ = 254 nm) or by charring the plates after spraying with 10% solution of sulfuric acid in ethanol. Crude products were purified using column chromatography performed on Silica Gel 60 (70–230 mesh, Fluka, St. Louis, MI, USA), developed using toluene:EtOAc or CHCl3:MeOH as solvent systems. All evaporations were performed on a rotary evaporator under diminished pressure at 40 °C. Reversed-phase HPLC analyses were performed using JASCO LC 2000 apparatus equipped with a reverse-phase column (Nucleosil 100 C18.5 μm, 25 × 0.4 cm; mobile phase: H2O/MeCN 90:10, flow rate 0.8 mL/min) with a fluorescence detector (FP). Fluorescence for substrate and product was read at 385 nm excitation/540 nm emission. The absorbance on MTT assay was measured spectrophotometrically at the 570 nm wavelength using a plate reader (Epoch, BioTek, USA).
All of the chemicals used in the experiments were purchased from Sigma-Aldrich, ACROS Organics, Fluka and Avantor and were used without purification. 8-Hydroxyquinoline 1, 8-hydroxyquinaldine 2, D-glucose 11 and D-galactose 12 are commercially available (Sigma-Aldrich). 8-(2-Propyn-1-yloxy)quinoline 3 [57 (link)], 2-methyl-8-(2-propyn-1-yloxy)quinoline 4 [57 (link)], 1,2,3,4,6-penta-O-acetyl-β-D-glucopyranose 13 [54 (link)], 1,2,3,4,6-penta-O-acetyl-β-D-galactopyranose 14 [54 (link)], 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide 15 [54 (link)], 2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl bromide 16 [54 (link)], 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl azide 17 [54 (link)], 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl azide 18 [54 (link)], 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl amine 19 [60 (link)], 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl amine 20 [60 (link)], propargyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside 21 [61 (link)], propargyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside 22 [61 (link)], 2-bromoethyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside 25 [62 (link)], 2-bromoethyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside 26 [62 (link)], 2-azidoethyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside 27 [62 (link)], 2-azidoethyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside 28 [62 (link)], 2,3,4,6-tetra-O-acetyl-N-(β-D-glucopyranosyl)propiolamide 37 [65 (link)], 2,3,4,6-tetra-O-acetyl-N-(β-D-galactopyranosyl)propiolamide 38 [65 (link)], 2,3,4,6-tetra-O-acetyl-N-(β-D-glucopyranosyl)-O-propargyl carbamate 41 [66 (link)] and 2,3,4,6-tetra-O-acetyl-N-(β-D-galactopyranosyl)-O-propargyl carbamate 42 [66 (link)] were prepared according to the respective published procedures. Propargyl β-D-glucopyranoside 23, propargyl β-D-galactopyranoside 24, 2-azidoethyl β-D-glucopyranoside 29, 2-azidoethyl β-D-galactopyranoside 30, N-(β-D-glucopyranosyl)azidoacetamide 35, N-(β-D-galactopyranosyl)azidoacetamide 36, N-(β-D-glucopyranosyl)propiolamide 39, N-(β-D-galactopyranosyl)propiolamide 40N-(β-D-glucopyranosyl)-O-propargyl carbamate 43, N-(β-D-galactopyranosyl)-O-propargyl carbamate 44 were obtained by Zemplén protocol [67 (link)] by deacetylation of the corresponding sugar derivatives.
Krawczyk M., Pastuch-Gawołek G., Pluta A., Erfurt K., Domiński A, & Kurcok P. (2019). 8-Hydroxyquinoline Glycoconjugates: Modifications in the Linker Structure and Their Effect on the Cytotoxicity of the Obtained Compounds. Molecules, 24(22), 4181.
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Publication 2019
2
Synthesis of Functional Polymers via Click Chemistry
Cited 3 times
1,3-Bis(isocyanatomethyl)cyclohexane, 1,3-bis(2-isocyanatopropan-2-yl)benzene, 4,4-methylenebis(cyclohexyl isocyanate), 4,4′-methylenebis(phenyl isocyanate), bis(4-hydroxyphenyl)methane, 6-chloro-1-hexanol, 8-chloro-1-octanol, dibutyltin dilaurate sodium azide, 1,1,1-tris(hydroxymethyl)propane, tris-1,3,5-bromomethylbenzene, phloro-glucinol, propargyl alcohol, propargyl bromide, allyl bromide, sodium hydride (NaH), sodium sulfate (Na2SO4), potassium thioacetate, diethyl azodicarboxylate (DEAD), tetrabutylammonium iodide, N,N,′,N′,N″ -pentamethyldiethylenetriamine (PMDETA), copper(II) chloride, 2,2-dimethoxy-2-phenylacetophenone (DMPA), triphenyl-phosphine (TPP), tetrahydrofuran (THF), dimethylformamide (DMF), and dimethyl sulfoxide (DMSO) were all purchased from Sigma-Aldrich and used without further purification. Potassium carbonate (K2CO3) and hydrochloric acid (HCl) were purchased from Fisher Scientific and used without further purification.
Baranek A., Song H.B., McBride M., Finnegan P, & Bowman C.N. (2016). Thermomechanical Formation–Structure–Property Relationships in Photopolymerized Copper-Catalyzed Azide–Alkyne (CuAAC) Networks. Macromolecules, 49(4), 1191-1200.
Publication 2016
allyl bromide Benzene Chlorides Copper Cyclohexane dibutyltin dilaurate Dimethylformamide Hexanols Hydrochloric acid Isocyanates Methane Octanols phenyl isocyanate Potassium potassium carbonate Propane propargyl alcohol propargyl bromide Sodium Azide sodium hydride sodium sulfate Sulfoxide, Dimethyl tetrabutylammonium iodide tetrahydrofuran triphenylphosphine Tromethamine
3
Synthesis of Multifunctional Monomers for Click Chemistry
Cited 3 times
1,3-Bis(isocyanatomethyl)cyclohexane, 4,4-methylenebis(cyclohexyl isocyanate), 1,3-bis(2-isocyanatopropan-2-yl)benzene, 4,4′-methylenebis(phenyl isocyanate), bis(4-hydroxyphenyl)-methane, 6-chloro-1-hexanol, dibutyltin dilaurate, sodium azide, 1,1,1-tris(hydroxymethyl)propane, pentaerythritol, 1,3,5-tris(bromomethyl)benzene, phloroglucinol, propargyl alcohol, sodium hydride, diethyl azodicarboxylate, tetrabutylammonium iodide, N,N,N′,N′,N″ -pentamethyldiethyl-enetriamine (PMDETA), copper(ii) chloride, triphenyl-phosphine, 2,2-dimethoxy-2-phenylacetophenone (DMPA), propargyl bromide, camphorquinone (CQ), tetrahydrofuran, and acetonitrile were used as received from Sigma Aldrich. 2,2,4,4-tetramethyl-1,3-cyclobutanediol, 5-hexyn-1-ol, hexyl isocyanate, 6-chloro-1-hexyne, 1-phenyl-1,2-propanedione (PPD), 2,2-bis-(bromomethyl)-1,3-propanediol, sodium hydroxide, potassium carbonate, potassium hydroxide, hydrochloric acid, methanol, acetone, methylene chloride, and dimethylformamide were used as received from Fisher Scientific. Diphenyl(2,4,6-trimethylbenzoyl)-phosphine oxide (Lucirin-TPO) was used as received from VWR International. Bis(2,4,6-trimethylbenzoyl)-phenylphosphineoxide (I819) was used as received from BASF. All azides were synthesized according to the azide safety rules and handled with appropriate care and precaution, and generally working with the monomers, resins and polymers in small quantities.54 Three facile reaction schemes, alcoholysis of isocyanates, Mitsunobu, and Williamson ether, were used to synthesize di-functional azides and multi-functional alkynes as indicated in Fig. 1. All NMR measurements and yields of monomers are presented in the ESI.†
Song H.B., Baranek A, & Bowman C.N. (2015). Kinetics of bulk photo-initiated copper(i)-catalyzed azide–alkyne cycloaddition (CuAAC) polymerizations. Polymer chemistry, 7(3), 603-612.
Publication 2015
Acetone acetonitrile Alkynes Azides Benzene camphorquinone Chlorides Copper Cyclohexane dibutyltin dilaurate Dimethylformamide diphenyl Ethyl Ether Hexanols Hydrochloric acid Isocyanates Lucirin TPO Methane Methanol Methylene Chloride Oxides pentaerythritol phenyl isocyanate Phloroglucinol phosphine Polymers potassium carbonate potassium hydroxide Propane propargyl alcohol propargyl bromide Propylene Glycol Resins, Plant Safety Sodium Azide sodium hydride Sodium Hydroxide tetrabutylammonium iodide tetrahydrofuran triphenylphosphine Tromethamine
4
Synthesis of Deuterated Allylaniline Intermediate
Cited 3 times
A solution of LiAlD4 (3.6 g, 85.6 mmol, 1.6 equiv) in dry Et2O (285 mL) was cooled to −10°C and a solution of propargyl alcohol (3.0 g, 53.5 mmol, 1 equiv) in Et2O (33 mL) was added through an addition funnel over 30 min. The resulting solution was warmed to room temperature and stirred for 14 h. The mixture was cooled to 0°C and was quenched slowly with H2O (4.0 mL). The solution was stirred for another 15 min and then 15% aqueous NaOH solution (4.0 mL) and H2O (4.0 mL) were added. The white slurry was filtered through a short pad of Celite and was washed with Et2O (300 mL). The filtrate was concentrated in vacuo to give the crude allyl-2-d1 alcohol4 as a yellow oil (3.0 g). 1H NMR (500 MHz, CDCl3): δ = 5.22 (s, 1H), 5.09 (s, 1H), 4.08 (s, 2H), 3.0 ppm (brs, 1H).
The crude allyl-2-[D1] alcohol (3.0 g, 50.8 mmol, 1 equiv) was added to a stirring solution of PBr3 (2.4 mL, 25.5 mmol, 0.5 equiv) in Et2O (21 mL) dropwise at 0°C. The resulting solution was stirred at 0°C for 1 h and then carefully quenched by the addition of brine (12 mL). The layers were separated and the combined organic extracts were washed with a saturated solution of NaHCO3, brine and dried over Na2SO4. Excess solvent was removed via careful distillation (45–50°C). The crude allyl-2-[D1] bromide was obtained as colorless liquid (2.1 g, 32% yield over 2 steps).[5 ] 1H NMR (500 MHz, CDCl3): δ = 5.31 (s, 1H), 5.14 (s, 1H), 3.94 ppm (s, 2H).
Into an oven-dried round bottom flask were added the crude allyl-2-[D1] bromide (1.5 mL, 12.5 mmol, 1.0 equiv), aniline (4.5 mL, 37.0 mmol, 3.0 equiv), K2CO3 (5.0 g, 37.0 mmol, 3.0 equiv) and DMF (20 mL).[6 ] The flask was equipped with a stopper and the reaction mixture was heated to 70°C overnight. The mixture was allowed to cool to room temperature and was washed with water (20 mL). The aqueous phase was extracted with Et2O (3 × 20 mL). The combined organic layers were washed with brine, dried with Na2SO4 and concentrated in vacuo. Purification by flash chromatography on SiO2 (10% EtOAc in hexanes) gave compound N-allyl-2-[D1] aniline (0.7 g, 45% yield). Data: 1H NMR (500 MHz, CDCl3): δ = 7.18 (t, J = 7.5 Hz, 2H), 6.72 (t, J = 7.5 Hz, 1H), 6.64 (d, J = 8.0 Hz, 2H), 5.29 (s, 1H), 5.17 (s, 1H), 3.78 ppm (s, 2H); 13C NMR (75 Hz, CDCl3): δ = 148.0, 135.1 (t, J = 23.0 Hz), 129.2, 117.5, 116.1, 112.9, 46.4 ppm; HRMS (ESI): m/z calcd for [M]+ C9H11DN1: 135.1027, found: 135.1022.
To an oven-dried pressure tube were added N-allyl-2-[D1] aniline (0.7 g, 5.2 mmol, 1 equiv) and xylenes (13 mL). The solution was cooled to −78°C and BF3·Et2O (1.3 mL, 10.4 mmol, 2.0 equiv) was added dropwise. The resulting solution was warmed to room temperature and was heated to 160°C for 4 h.[7 (link)] The reaction mixture was then cooled to room temperature and was placed in an ice–water bath and was quenched with 2M NaOH (6 mL). The organic layer was separated and aqueous layer was extracted with Et2O (3 × 10 mL). The organics were combined, dried with Na2SO4, filtered and concentrated in vacuo. Purification by flash chromatography on SiO2 (10% EtOAc in hexanes) gave o-allyl-2-[D1] aniline (0.5 g, 70% yield). 1H NMR (500 MHz, CDCl3): δ = 7.05 (t, J = 8.0 Hz, 2H), 6.75 (t, J = 7.5 Hz, 1H), 6.64 (d, J = 8.0 Hz, 1H), 5.12 (s, 1H), 5.10 s, 1H), 3.66 (brs, 2H), 3.30 ppm (s, 2H); HRMS (ESI): m/z calcd for [M+ H]+ C9H11DN1: 135.1012, found: 135.1009.
The o-allyl-2-[D1] aniline (0.5 g, 3.7 mmol, 1 equiv) was dissolved in dry CH2Cl2 (20 mL) and the solution was treated with pyridine (1.18 mL, 14.9 mmol, 4 equiv) followed by p-toluenesulfonyl chloride (0.85 g, 4.5 mmol, 1.2 equiv). The mixture was stirred at room temperature for 24 h, washed with 1N HCl (15 mL) and extracted with CH2Cl2 (3 × 15 mL). The combined organic layers were washed with brine, dried over Na2SO4, and concentrated in vacuo. Flash chromatography of the resulting crude compound on SiO2 (5–10% EtOAc in hexanes) afforded compound [D]-1b as white solid (1.0 g, 96% yield). M.p. 62–65°C; 1H NMR (500 MHz, CDCl3): δ = 7.61 (d, J = 8.5 Hz, 2H), 7.41 (d, J = 8.5 Hz, 1H), 7.23 (d, J = 8.5 Hz, 2H), 7.19 (m, 1H), 7.13–7.05 (m, 2H), 6.55 (b. s., 1H), 5.11 (s, 1H), 4.93 (s, 1H), 3.00 (s, 2H), 2.39 ppm (s, 3H); 13C NMR (75 Hz, CDCl3): δ = 143.7, 136.7, 135.2 (t, J = 24 Hz), 134.9, 131.9, 130.4, 129.5, 127.6, 127.0, 126.2, 124.4, 116.9, 36.0, 21.5 ppm; IR (neat): ν̃ = 3266, 3076, 3030, 2967, 2913, 2849, 2243, 1922, 1623, 1596, 1492, 1451, 1401, 1333, 1161, 1089, 1039, 1016, 921, 817, 754, 663 cm−1; HRMS (ESI): m/z calcd for [M]+ C16H16DO2N1S1: 288.1037, found: 288.1036.
Paderes M.C., Belding L., Fanovic B., Dudding T., Keister J.B, & Chemler S.R. (2012). Evidence for Alkene cis-Aminocupration, an Aminooxygenation Case Study: Kinetics, EPR Spectroscopy, and DFT Calculations. Chemistry (Weinheim an Der Bergstrasse, Germany), 18(6), 1711-1726.
Publication 2012
5
Synthesis and Functionalization of Dendron-Polymer Conjugates
Cited 2 times
Propargyl-poly(amido amine) dendron synthesis was adapted from published procedures.33 Azide functionalisation of poly(HEMA-ran-GMA) polymers was achieved by treating copolymer 3a with sodium azide and ammonium chloride in DMF. The reaction was allowed to proceed at 60 °C for 72 h. The solution was cooled, insoluble byproducts were removed by centrifugation, and the product 4a was purified by repetitive precipitation in ether and dried under vacuum. Other copolymers were treated the same way and reactions scaled accordingly. PAMAM dendrons were attached to the azido-functionalised polymers by a copper-catalysed alkyne–azide click reaction, adapted from Zhao et al.34 For reaction with 4a, 3.5G propargyl-PAMAM dendron (5) was dissolved in DMF before addition of 4a. Pentamethyldiethylenetriamine was added and the solution was degassed. The reaction commenced at room temperature with the addition of copper(i) bromide and proceeded for 72 h. Product 7a was purified by dialysis against deionised water and collected via lyophilisation. Dendron generation was completed by reaction with ethylenediamine, before being purified by dialysis against deionised water and collected by lyophilisation to yield product 9a.
Kretzmann J.A., Ho D., Evans C.W., Plani-Lam J.H., Garcia-Bloj B., Mohamed A.E., O'Mara M.L., Ford E., Tan D.E., Lister R., Blancafort P., Norret M, & Iyer K.S. (2017). Synthetically controlling dendrimer flexibility improves delivery of large plasmid DNA †Electronic supplementary information (ESI) available: Detailed methods, chemical and cell-based characterization. See DOI: 10.1039/c7sc00097a Click here for additional data file.. Chemical Science, 8(4), 2923-2930.
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Publication 2017
2-hydroxyethyl methacrylate Alkynes Amines Anabolism Azides Bromides Centrifugation Chloride, Ammonium Copper dendron Dialysis Ethylenediamines Ethyl Ether Freeze Drying PAMAM dendrimer Poly A Polymers Sodium Azide Vacuum

Most recents protocols related to «Propargyl bromide»

1
Synthesis of O-Propargyl Benzaldehyde
Propargyl bromide (23 mmol) was added to a solution containing 4-hydroxybenzaldehyde (compound 7, 23 mmol) and potassium carbonate (22 mmol) in 10 mL of dry DMF. The reaction mixture was stirred at room temperature for 2 h and then extracted with ethyl acetate to obtain crude O-propargyl benzaldehyde.
Bagheri A., Moradi S., Iraji A, & Mahdavi M. (2024). Structure-based development of 3,5-dihydroxybenzoyl-hydrazineylidene as tyrosinase inhibitor; in vitro and in silico study. Scientific Reports, 14, 1540.
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Publication 2024
2
Propargylation of Kraft Pulp Fibers
The procedure for the preparation of propargylated kraft pulp fibers (KFT-Pr), was based on Faugeras et al.,22 (link) with some modifications to reaction conditions. The reaction time and the volume of propargyl bromide were increased. 76 mL (0.640 mol) of propargyl bromide was added to 1 L of an alkaline suspension of fibers (20 g, 124 mmol). The reaction medium was placed under mechanical stirring at room temperature. After 96 h, the mixture was diluted with 2 L of deionized water, let to rest for 4 h, filtered and washed with 2 × 1 L of hot water and 1 L of hot ethanol.
Blal A., Brouillette F., Loranger É, & Lebrun G. (2024). Click chemistry modifications for the selective crosslinking of wood pulp fibers – effect on the physical and mechanical properties of paper. RSC Advances, 14(14), 9656-9667.
Publication 2024
3
Synthesis of 5-FUD-Gal via Click Chemistry
To synthesize 5-FUD-Gal, azido
galactopyranose (III) was synthesized by a series of
reactions, protection of the hydroxyl group on the 2,3,4,5 positions,
tosylation of the hydroxyl group on the 6 position, and substitution
of the tosyl with the azido group. Then, N-1-propargyl
5-fluorouracil was synthesized from 5-fluorouracil and propargyl bromide
(IV). Finally, 5-FUD-Gal was synthesized from azido galactopyranose
(III) and N-1-propargyl 5-fluorouracil
(IV) via copper-catalyzed azide–alkyne cycloaddition
click reaction (Figure 1).14 (link)
, & Köksal Karayildirim Ç. (2024). Preparation, Characterization, and Antiangiogenic Evaluation of a Novel 5-Fluorouracil Derivative Solid Lipid Nanoparticle with a Hen’s Egg Chorioallantoic Membrane Assay and Wound Healing Response in HaCaT Keratinocytes. ACS Omega, 9(14), 16640-16647.
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Publication 2024
4
Cellulose Pulp Functionalization
A commercial bleached softwood kraft pulp was provided by Fraser Paper (Thurso, Canada). Chemical reagents were purchased from suppliers: propargyl bromide (80% in toluene), p-toluenesulfonyl chloride and sodium azide (Alfa Aesar), sodium hydroxide and copper sulfate pentahydrate (CuSO4·5H2O) (Acros Organics), dimethylformamide, sodium ascorbate, and triethylamine (Sigma-Aldrich). All materials were used as received without any further purification.
Blal A., Brouillette F., Loranger É, & Lebrun G. (2024). Click chemistry modifications for the selective crosslinking of wood pulp fibers – effect on the physical and mechanical properties of paper. RSC Advances, 14(14), 9656-9667.
Publication 2024
5
Synthesis of Propargyl-Terminated Polyoxypropylene
Not available on PMC !

Example 5

Propylene oxide was polymerized using polyoxypropylene triol having a number average molecular weight of about 3,000, serving as an initiator, and a zinc hexacyanocobaltate-glyme complex catalyst to thereby obtain polyoxypropylene (P-1) having hydroxyl groups at ends and having a number average molecular weight of 24,600 (end group-based molecular weight: 17,400) and a molecular weight distribution Mw/Mn of 1.31. To the hydroxyl groups in the resultant hydroxyl group-terminated polyoxypropylene (P-1), was added 1.05 mol equivalents of sodium methoxide as a 28% methanol solution. The methanol was distilled off by vacuum devolatilization, and then 1.16 mol equivalents of propargyl bromide was further added to the hydroxyl groups in the polymer (P-1) to thereby convert the terminal hydroxyl groups into propargyl groups. Unreacted propargyl bromide was removed by devolatilization under reduced pressure. The resultant crude propargyl group-terminated polyoxypropylene was mixed and stirred with n-hexane and water, and then the water was removed by centrifugation and the hexane was devolatilized under reduced pressure from the resultant hexane solution to thereby remove a metal salt in the polymer. Thus, polyoxypropylene (Q-1) having propargyl groups at end sites was obtained. To 500 g of the polymer (Q-1), were added 150 μL of a platinum-divinyldisiloxane complex (3 wt % isopropanol solution in terms of platinum) and 11.49 g of methoxymethyldimethoxysilane, to thereby effect a hydrosilylation reaction. After reacting at 90° C. for 2 hours, unreacted methoxymethyldimethoxysilane was distilled off under reduced pressure to thereby obtain polyoxypropylene (A-2) having methoxymethyldimethoxysilyl groups at ends and having a number average molecular weight of 26,200. The polymer (A-2) was found to have on average 3.0 methoxymethyldimethoxysilyl groups per molecule.

Example 9

To 500 g of the polymer (Q-2) obtained in Synthesis Example 5, were added 150 μL of a platinum-divinyldisiloxane complex (3 wt % isopropanol solution in terms of platinum) and 4.8 g of dimethoxymethylsilane, to thereby effect a hydrosilylation reaction. After reacting at 90° C. for 2 hours, unreacted dimethoxymethylsilane was distilled off under reduced pressure to thereby obtain polyoxypropylene (E-3) having dimethoxymethylsilyl groups at ends and having a number average molecular weight of 28,500. The polymer (E-3) was found to have on average 1.6 dimethoxymethylsilyl groups per molecule.

US11859037B2. Reactive silicon group-containing polymer and curable composition (2024-01-02). KANEKA CORPORATION [JP]. Inventors: Tatsuro Harumashi [JP], Nodoka Kubota [JP].
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Patent 2024

Top products related to «Propargyl bromide»

1
Propargyl bromide by Merck Group
Sourced in United States, India
Propargyl bromide is a halogenated organic compound used as a laboratory reagent. It is a colorless, volatile liquid with a pungent odor. Propargyl bromide is commonly used in organic synthesis as an alkylating agent and as a precursor for other chemical reactions.
2
Sodium azide by Merck Group
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Sodium azide is a chemical compound commonly used in laboratory applications. It functions as a preservative and acts as a source of the azide ion, which can be utilized in various experimental and analytical procedures. This product is intended for use by qualified professionals in controlled laboratory settings.
3
Xylene by Merck Group
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Xylene is a common laboratory solvent used for various applications in scientific research and analysis. It is a clear, colorless liquid with a distinctive aromatic odor. Xylene's primary function is as a dehydrating agent and clearing agent in histological and microscopy sample preparation, where it is used to replace water and prepare samples for embedding in paraffin or resin.
4
Propargyl alcohol by Merck Group
Sourced in United States
Propargyl alcohol is a colorless, flammable liquid chemical compound. It is a primary alcohol with an alkyne functional group. Propargyl alcohol has the chemical formula C3H4O and is used as an industrial chemical in various applications.
5
Dimethyl sulfoxide (dmso) by Merck Group
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DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.
6
Sodium ascorbate by Merck Group
Sourced in United States, Germany, France, United Kingdom
Sodium ascorbate is a water-soluble salt of ascorbic acid (vitamin C). It serves as a source of vitamin C for various laboratory and research applications.
7
Copper 1 bromide by Merck Group
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Copper(I) bromide is a chemical compound with the formula CuBr. It is a yellow crystalline solid that is used as a precursor in various chemical synthesis reactions.
8
Triethylamine by Merck Group
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Triethylamine is a clear, colorless liquid used as a laboratory reagent. It is a tertiary amine with the chemical formula (CH3CH2)3N. Triethylamine serves as a base and is commonly employed in organic synthesis reactions.
9
Ethanol by Merck Group
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Ethanol is a clear, colorless liquid chemical compound commonly used in laboratory settings. It is a key component in various scientific applications, serving as a solvent, disinfectant, and fuel source. Ethanol has a molecular formula of C2H6O and a range of industrial and research uses.
10
Sodium azide nan3 by Merck Group
Sourced in United States, Germany, China, Italy, Poland
Sodium azide (NaN3) is an inorganic compound that is commonly used as a laboratory reagent. It is a white crystalline solid that is soluble in water and other polar solvents. The core function of sodium azide is as a chemical precursor and preservative.

More about "Propargyl bromide"

Propargyl bromide, also known as 3-bromopropyne, is a versatile chemical compound that has a wide range of applications in organic synthesis and materials science.
This highly reactive species can undergo a variety of reactions, making it a valuable precursor for the preparation of other compounds.
Propargyl bromide is commonly used in the synthesis of various heterocyclic compounds, such as those containing nitrogen, oxygen, or sulfur atoms.
It can also be used in the preparation of organometallic compounds, which find applications in catalysis and materials science.
In addition to its use in organic synthesis, propargyl bromide is also employed in the production of certain polymers and other materials.
For example, it can be used in the synthesis of polyurethanes, epoxy resins, and other specialty materials.
While propargyl bromide is a useful chemical, it is also highly reactive and must be handled with caution.
Proper safety precautions, such as the use of personal protective equipment and appropriate containment measures, are essential when working with this compound.
To enhance research reproducibility and accuracy, the PubCompare.ai tool can be a valuable resource for researchers working with propargyl bromide.
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By utilizing PubCompare.ai, researchers can streamline their propargyl bromide-related research, improving efficiency and ultimately enhancing the quality and impact of their work.
Whether you are exploring the synthesis of new compounds, developing novel materials, or optimizing existing processes, PubCompare.ai can be the ultimate solution for your propargyl bromide needs.