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Quinine
Quinine
Quinine is a naturally occurring alkaloid derived from the bark of the cinchona tree.
It has been used for centuries as an effective treatment for malaria, due to its antimalarial properties.
Quinine acts by interfering with the parasite's ability to break down and utilize hemoglobin, ultimately leading to the parasite's death.
In addition to its antimalarial uses, quinine has also been employed as a muscle relaxant and in the treatment of nocturanl leg craps.
Researchers continue to investigate quinine's potential therapeutic applications, as well as its pharmacokinetics and safety profile.
The PubCompare.ai platform can help optimize quinine research by providing easy access to relevant protocols from the literature, preprints, and patents, while offering powerful comparision tools to identify the best approaches for your needs.
Streamlline your quinine reseach with PubCompare.ai's curated, reproducible protocols.
It has been used for centuries as an effective treatment for malaria, due to its antimalarial properties.
Quinine acts by interfering with the parasite's ability to break down and utilize hemoglobin, ultimately leading to the parasite's death.
In addition to its antimalarial uses, quinine has also been employed as a muscle relaxant and in the treatment of nocturanl leg craps.
Researchers continue to investigate quinine's potential therapeutic applications, as well as its pharmacokinetics and safety profile.
The PubCompare.ai platform can help optimize quinine research by providing easy access to relevant protocols from the literature, preprints, and patents, while offering powerful comparision tools to identify the best approaches for your needs.
Streamlline your quinine reseach with PubCompare.ai's curated, reproducible protocols.
Most cited protocols related to «Quinine»
Adult
artemisinine
Child
Ethics Committees, Research
LDH 5
Legal Guardians
Malaria
Parenteral Nutrition
Patients
Plasmodium falciparum
POU5F1 protein, human
Quinine
Rapid Diagnostic Tests
Youth
Women were encouraged to attend the ANC clinic whenever they had any health complaint. Health care was free of charge and in general there was little availability of antimalarial drugs over the counter at all sites. A health facility-based passive surveillance system was established at each site to capture unscheduled visits of the study participants during the study follow-up. At each unscheduled visit, a standardized questionnaire was completed documenting signs and symptoms. Blood smears were prepared for malaria parasite examination and hemoglobin was measured if there were current or reported symptoms and/or signs suggestive of malaria. Clinical malaria episodes were treated with oral quinine or artemether-lumefantrine in the first and subsequent trimesters, respectively, for uncomplicated malaria, and with parenteral quinine for severe malaria. Solicited and unsolicited adverse events (AEs) were assessed. The former was done by directed questioning of malaria related signs and symptoms during unscheduled visits, whereas the latter were assessed through open questioning during scheduled visits. Women who were withdrawn from the study received routine ANC treatment.
At delivery, women's peripheral blood, cord blood, and placental (biopsy and impression smears) samples were collected for hematological and parasitological evaluation. Newborns were weighed (weekly calibrated scales, either digital or three beam balances), and their gestational age at birth evaluated using the Ballard's score [27] (link). Newborn weights not captured at birth but within the first week of life were estimated using a linear regression model (Figure S1 ) [28] (link). One month after the end of pregnancy, a capillary blood sample from the mother was collected for malaria parasite determination. LLITN use was assessed at each study visit by questions about use the preceding night.
At delivery, women's peripheral blood, cord blood, and placental (biopsy and impression smears) samples were collected for hematological and parasitological evaluation. Newborns were weighed (weekly calibrated scales, either digital or three beam balances), and their gestational age at birth evaluated using the Ballard's score [27] (link). Newborn weights not captured at birth but within the first week of life were estimated using a linear regression model (
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Antimalarials
Biopsy
BLOOD
Capillaries
Childbirth
Drugs, Non-Prescription
Gestational Age
Hemoglobin
Infant, Newborn
Lumefantrine, Artemether
Malaria
Mothers
Obstetric Delivery
Parasites
Parenteral Nutrition
Placenta
Pregnancy
Quinine
Umbilical Cord Blood
Woman
Diptera
Ethanol
Fluorescence
Neoplasm Metastasis
Pheromone
Quinine
Sodium Chloride
Sucrose
Adult
amodiaquine, artesunate drug combination
Antimalarials
Axilla
BLOOD
Child
Ethics Committees
Ethics Committees, Research
Faculty, Medical
Feces
Fever
Helminthiasis
Hemoglobin
Homo sapiens
Immunosuppressive Agents
Legal Guardians
Malaria
Parasitemia
Parent
Parenteral Nutrition
Patients
Pharmaceutical Preparations
Physical Examination
Physicians
Pregnancy
Protective Agents
Protocol Compliance
Quinine
Rain
Response, Immune
Urine
Veins
Acceleration
Artesunate
Case Management
Chemoprevention
Child
Disease Management
Homo sapiens
Innovativeness
Insecticide Resistance
Insecticides
Malaria
Pharmaceutical Preparations
Pyrethroids
Quinine
SLC6A2 protein, human
sulphadoxine-pyrimethamine
Susceptibility, Disease
Most recents protocols related to «Quinine»
Example 52
Methanesulfonyl chloride (9.23 mg, 80.5 umol, 6.2 uL, 1 eq) was added to the mixture of compound 52-1 (30 mg, 80.5 umol, 1 eq) and TEA (24.46 mg, 0.24 mmol, 33.6 uL, 3 eq) in DCM (1 mL) at 0° C., then the mixture was stirred at 20° C. for 3 hr. LC-MS showed the desired compound was detected. The reaction mixture was diluted with H2O (10 mL) and the mixture was extracted with EA (15 mL*3). The combined organic phase was washed with brine (10 mL*3), dried with anhydrous Na2SO4, filtered and concentrated in vacuum. The residue was purified by prep-HPLC. The title compound (10 mg, 21.9 umol, 27.2% yield) was obtained as white solid. LCMS (ESI): RT=0.808 min, mass calc. for C22H21F3N2O3S 450.47, m/z found 451.2 [M+H]+; 1H NMR (400 MHz, CD3OD) δ 8.27 (s, 1H), 7.82 (d, J=2.0 Hz, 1H), 7.75 (d, J=8.0 Hz, 2H), 7.69-7.67 (m, 2H), 7.59 (d, J=8.0 Hz, 2H), 7.32 (d, J=2.3 Hz, 1H), 4.16 (quin, J=6.5 Hz, 1H), 2.98 (s, 3H), 1.19 (d, J=6.8 Hz, 6H).
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1H NMR
brine
High-Performance Liquid Chromatographies
Lincomycin
methanesulfonyl chloride
Quinine
Vacuum
Example 93
To a solution of compound 101-1 (50.0 mg, 0.15 mmol, 1.0 eq), compound 101-1a (23.1 mg, 0.18 mmol, 1.2 eq) and DIPEA (40.7 mg, 0.31 mmol, 2.0 eq) in DCM (3 mL) was added HATU (89.9 mg, 0.23 mmol, 1.5 eq). The reaction mixture was stirred at 25° C. for 1 hour. LC-MS showed starting material was consumed completely and one main peak with desired MS was detected. The reaction mixture was concentrated under reduced pressure. The mixture was diluted with water (10 mL) and the resultant mixture was extracted with EA (20 mL*3). The combined organic layers were dried over Na2SO4, filtered and concentrated to dryness under reduced pressure. The residue was purified by prep-HPLC to give the title compound (27.8 mg, 41% yield) as a white solid. LCMS (ESI): RT=0.841 min, mass calcd. for C24H18F3N3O 421.14 m/z found 422.1 [M+H]+; 1H NMR (400 MHz, CDCl3) δ 9.42 (d, J=2.3 Hz, 1H), 8.78 (d, J=2.3 Hz, 1H), 8.60 (d, J=4.5 Hz, 1H), 8.22 (br d, J=6.8 Hz, 1H), 8.02 (dd, J=1.3, 8.0 Hz, 1H), 7.87-7.82 (m, 3H), 7.81-7.77 (m, 2H), 7.77-7.69 (m, 2H), 7.35 (d, J=7.8 Hz, 1H), 7.28-7.25 (m, 1H), 5.41 (quin, J=6.8 Hz, 1H), 1.67 (s, 3H).
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1H NMR
DIPEA
High-Performance Liquid Chromatographies
Lincomycin
Pressure
Quinine
quinoline-3-carboxamide
Example 119
The mixture of compound 127-1 (100 mg, 0.25 mmol, 1 eq), BrCN (82.2 mg, 0.77 mmol, 57.1 uL, 3 eq) and TEA (104.7 mg, 1.04 mmol, 0.14 mL, 4 eq) in DCM (2 mL) was stirred at 0° C. for 1 hr. LC-MS and HPLC showed the desired compound was detected. The reaction mixture was diluted with H2O (10 mL) and the mixture was extracted with EA (10 mL*3). The combined organic phase was washed with brine (10 mL*2), dried with anhydrous Na2SO4, filtered and concentrated in vacuum. The residue was purified by prep-HPLC. The title compound (18 mg, 43.3 umol, 16.7% yield) was obtained as brown solid. LCMS (ESI): RT=0.960 min, mass calcd for C23H20F3N3O 411.42 m/z, found 412.0 [M+H]+; 1H NMR (400 MHz, CD3OD) δ 8.47 (d, J=1.5 Hz, 1H), 8.07-8.03 (m, 1H), 7.88-7.80 (m, 5H), 7.67-7.61 (m, 3H), 7.55-7.51 (m, 1H), 3.54 (t, J=6.9 Hz, 2H), 3.37-3.31 (m, 1H), 3.16 (t, J=7.0 Hz, 2H), 2.91 (s, 3H), 2.01 (quin, J=7.0 Hz, 2H).
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1H NMR
brine
High-Performance Liquid Chromatographies
Lincomycin
Quinine
Vacuum
Example 34
A mixture of isopropyl 3-((6-chloro-3-((methyl-d3)carbamoyl)pyridazin-4-yl)amino)-4-methoxy-5-(2-methyl-2H-1,2,3-triazol-4-yl)benzoate (40 mg, 0.086 mmol), cyclopropane-carboxamide (36.8 mg, 0.432 mmol), Pd2(dba)3, chloroform adduct (8.93 mg, 8.64 μmol), xantphos (10.00 mg, 0.017 mmol) and Cs2CO3 (113 mg, 0.346 mmol) in dioxane (0.6 mL) was degassed by bubbling N2 through the mixture for 5 minutes. The reaction vessel was sealed and heated to 130° C. for 30 minutes. The reaction mixture was diluted with DMSO, filtered and purified by preparative HPLC. The pure fractions were concentrated to afford isopropyl 3-((6-(cyclopropanecarboxamido)-3-((methyl-d3)carbamoyl)pyridazin-4-yl)amino)-4-methoxy-5-(2-methyl-2H-1,2,3-triazol-4-yl)benzoate (17.5 mg; 39.6%). MS (M+1) m/z: 512.2 (M+H)+. LC retention time 1.83 [I]. 1H NMR (500 MHz, DMSO-d6) δ 11.36 (s, 1H), 11.22 (s, 1H), 9.16 (s, 1H), 8.27 (d, J=2.0 Hz, 1H), 8.22 (s, 1H), 8.17 (s, 1H), 8.03 (d, J=2.0 Hz, 1H), 5.15 (quin, J=6.2 Hz, 1H), 4.26 (s, 3H), 3.73 (s, 3H), 2.15-2.01 (m, 1H), 1.32 (d, J=6.2 Hz, 6H), 0.89-0.74 (m, 4H).
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1H NMR
Benzoate
Blood Vessel
Chloroform
cyclopropane
Dioxanes
High-Performance Liquid Chromatographies
Quinine
Retention (Psychology)
Sulfoxide, Dimethyl
xantphos
Example 226
To a solution of 226-1 (25 mg, 79 umol, 1 eq) and HATU (45.1 mg, 0.12 mmol, 1.5 eq) in DMF (1 mL) at 30° C. were added 226-1a (12.3 mg, 95 umol, 10 uL, 1.2 eq) and TEA (24.00 mg, 0.24 mmol, 33 uL, 3 eq). The mixture was stirred at 30° C. for 16 h. The reaction mixture was concentrated under reduced pressure to give a residue, which was purified by prep-HPLC (column: Waters Xbridge 150*25 5u; mobile phase: [water (0.05% ammonia hydroxide v/v)-ACN]; B %: 65%-95%, 7 min) to give the title compound (20 mg, 51 umol, 64.6% yield) as a white solid. LCMS (ESI): RT=0.900 min, mass calc. for C21H17ClF3NO 391.10, m/z found 392.0 [M+H]+; 1H NMR (400 MHz, CDCl3) δ 8.38 (d, J=1.8 Hz, 1H), 7.99 (d, J=8.3 Hz, 1H), 7.91-7.84 (m, 1H), 7.82-7.74 (m, 3H), 7.65-7.58 (m, 3H), 7.52 (dd, J=1.0, 7.0 Hz, 1H), 6.54 (brs, 1H), 4.93-4.89 (m, 1H), 3.75-3.66 (m, 4H), 2.19 (quin, J=6.5 Hz, 2H)
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1H NMR
Ammonia
compound 20
High-Performance Liquid Chromatographies
hydroxide ion
Lincomycin
Pressure
Quinine
Top products related to «Quinine»
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Quinine is a naturally occurring chemical compound found in the bark of the cinchona tree. It is a white, crystalline alkaloid with a bitter taste. Quinine's core function is as an active ingredient in certain medications, primarily used to treat malaria.
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Sucrose is a disaccharide composed of glucose and fructose. It is commonly used as a laboratory reagent for various applications, serving as a standard reference substance and control material in analytical procedures.
Sourced in United States
Quinine hemisulfate is a salt compound used in laboratory settings. It is a white, crystalline powder that is soluble in water and exhibits specific chemical properties. Quinine hemisulfate serves as a reference standard or calibration material for various analytical techniques, but its detailed applications and intended uses are not provided in this unbiased, factual description.
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Saccharin is a laboratory-grade artificial sweetener used as a reference standard in analytical procedures. It is a white, crystalline powder with a sweet taste. Saccharin serves as a comparison compound for the identification and quantification of other sweeteners in food, beverage, and pharmaceutical products.
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Chloroquine is a laboratory chemical primarily used as a research tool in biochemical and cell biology applications. It is a white, crystalline solid that is soluble in water. Chloroquine is commonly used in experiments to study cellular processes, such as autophagy and endocytosis, by inhibiting the function of lysosomes. Its core function is to serve as a research reagent for scientific investigations, without making any claims about its intended use.
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Fetal Bovine Serum (FBS) is a cell culture supplement derived from the blood of bovine fetuses. FBS provides a source of proteins, growth factors, and other components that support the growth and maintenance of various cell types in in vitro cell culture applications.
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Methanol is a clear, colorless, and flammable liquid that is widely used in various industrial and laboratory applications. It serves as a solvent, fuel, and chemical intermediate. Methanol has a simple chemical formula of CH3OH and a boiling point of 64.7°C. It is a versatile compound that is widely used in the production of other chemicals, as well as in the fuel industry.
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Caffeine is a naturally occurring stimulant compound that can be extracted and purified for use in various laboratory applications. It functions as a central nervous system stimulant, inhibiting the action of adenosine receptors in the brain.
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Quinine hydrochloride dihydrate is a chemical compound used in laboratory settings. It is a salt of quinine, which is a naturally occurring alkaloid. The dihydrate form refers to the presence of two water molecules in the crystal structure. This compound is often used as a reference standard or for other analytical purposes in various fields of research and development.
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DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.
More about "Quinine"
Quinine, a natural alkaloid derived from the cinchona tree, has been a celebrated treatment for malaria for centuries due to its potent antimalarial properties.
This phytochemical compound works by disrupting the parasite's ability to metabolize hemoglobin, leading to its demise.
Beyond its well-known use against malaria, quinine has also found applications as a muscle relaxant and in the management of nocturnal leg cramps.
Researchers continue to explore the diverse therapeutic potential of quinine, investigating its pharmacokinetics and safety profile.
The PubCompare.ai platform can optimize your quinine research by providing easy access to a wealth of relevant protocols from the literature, preprints, and patents.
Leveraging powerful comparison tools, you can identify the best approaches tailored to your specific needs, streamlining your quinine research with curated, reproducible protocols.
Whether you're studying quinine's antimalarial mechanisms, evaluating its use as a muscle relaxant, or exploring novel applications, PubCompare.ai's AI-driven platform can help you navigate the landscape, access crucial data, and make informed decisions to advance your quinine-related projects.
In addition to quinine, the platform also covers a range of related compounds, such as sucrose, quinine hemisulfate, saccharin, chloroquine, FBS, methanol, caffeine, and quinine hydrochloride dihydrate, providing a comprehensive resource for your research needs.
Unlock the full potential of quinine with the power of PubCompare.ai.
This phytochemical compound works by disrupting the parasite's ability to metabolize hemoglobin, leading to its demise.
Beyond its well-known use against malaria, quinine has also found applications as a muscle relaxant and in the management of nocturnal leg cramps.
Researchers continue to explore the diverse therapeutic potential of quinine, investigating its pharmacokinetics and safety profile.
The PubCompare.ai platform can optimize your quinine research by providing easy access to a wealth of relevant protocols from the literature, preprints, and patents.
Leveraging powerful comparison tools, you can identify the best approaches tailored to your specific needs, streamlining your quinine research with curated, reproducible protocols.
Whether you're studying quinine's antimalarial mechanisms, evaluating its use as a muscle relaxant, or exploring novel applications, PubCompare.ai's AI-driven platform can help you navigate the landscape, access crucial data, and make informed decisions to advance your quinine-related projects.
In addition to quinine, the platform also covers a range of related compounds, such as sucrose, quinine hemisulfate, saccharin, chloroquine, FBS, methanol, caffeine, and quinine hydrochloride dihydrate, providing a comprehensive resource for your research needs.
Unlock the full potential of quinine with the power of PubCompare.ai.