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Ranitidine

Ranitidine is a histamine H2-receptor antagonist used in the treatment of various gastrointestinal disorders, including peptic ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome.
It works by reducing the production of stomach acid, allowing the esophagus, stomach, and duodenum to heal.
Ranitidine is generally well-tolerated, with potential side effects including headache, dizziness, and constipation.
Researchers continue to explore the optimal use of ranitidine in clinical practice, as well as potential new applications and formulations of this versatile medication.

Most cited protocols related to «Ranitidine»

1
Antagonizing H1HR and H2HR in CCA
Cited 5 times
Cholangiocytes were treated with H1HR or H2HR antagonists and proliferation was measured by MTS assay and BrdU incorporation (15 (link), 16 (link), 22 (link)).
Similar to our in vivo studies, we performed experiments to determine the effects of blocking either H1HR or H2HR on CCA proliferation by MTS assay, and angiogenesis and EMT by real-time PCR. CCA cells were treated for up to 24 hours with vehicle, mepyramine or ranitidine prior to MTS assay and real-time PCR. Invasion was measured using a commercially available kit following vehicle, H1HR or H2HR antagonist treatment. The QCM ECMatrix Cell Invasion Assay was purchased from EMD Millipore (Billerica, MA) and used per manufacturer’s instructions (13 (link)).
Kennedy L., Hargrove L., Demieville J., Karstens A., Jones H., DeMorrow S., Meng F., Invernizzi P., Bernuzzi F., Alpini G., Smith S., Akers A., Meadows V, & Francis H. (2018). Blocking H1/H2 histamine receptors inhibits damage/fibrosis in Mdr2−/− mice and human cholangiocarcinoma tumorigenesis. Hepatology (Baltimore, Md.), 68(3), 1042-1056.
Publication 2018
angiogen antagonists Biological Assay Bromodeoxyuridine Cardiac Arrest Cells Pyrilamine Ranitidine Real-Time Polymerase Chain Reaction
2
Histamine Receptor Antagonism in Mdr2 Mice
Cited 5 times
Male WT and Mdr2−/− mice (8 weeks of age) were implanted with osmotic minipumps to deliver 0.9% NaCl (saline) or 10 mg/kg BW/day (18 (link), 19 (link)) of either mepyramine (H1HR antagonist), ranitidine (H2HR antagonist). In separate experiments, male Mdr2−/− mice (8 weeks of age) were treated with a combination of mepyramine and ranitidine (H1HR/H2HR antagonist) for 4 weeks to mimic chronic usage. Male mice (8 – 10 mice per group) were euthanized at 12 weeks of age, where these mice display an increase in PSC-induced hepatic damage (7 , 10 (link)). From these groups, we collected liver blocks (frozen and paraffin-embedded), serum, cholangiocytes and cholangiocyte supernatants, as described (7 , 20 ).
Kennedy L., Hargrove L., Demieville J., Karstens A., Jones H., DeMorrow S., Meng F., Invernizzi P., Bernuzzi F., Alpini G., Smith S., Akers A., Meadows V, & Francis H. (2018). Blocking H1/H2 histamine receptors inhibits damage/fibrosis in Mdr2−/− mice and human cholangiocarcinoma tumorigenesis. Hepatology (Baltimore, Md.), 68(3), 1042-1056.
Publication 2018
Freezing Liver Males Mice, House Normal Saline Osmosis Paraffin Pyrilamine Ranitidine Saline Solution Serum
3
Permeation Studies Using Franz Diffusion Cell
Cited 4 times
Permeation studies were performed using a Franz vertical diffusion cell (MicroettePlus, Hanson Research, CA, USA). Impregnated artificial membranes (Franz–PAMPA) were positioned between upper and lower part of diffusion cells and, the donor (1 mL) and receptor (7 mL) compartments holding phosphate-buffered solution (PBS) pH 7.4 (USP 32). In order to minimize the unstirred water layer (UWL), receptor compartment media was stirred (500 rpm). The temperature was kept constant (37.0 ± 0.5 °C). Each drug (n = 3) was added in the donor compartment at a fixed concentration (=10 mg/mL). One milliliter of saturated drug solutions was transferred to the donor compartments and capped to prevent evaporation. The experiments were performed under ‘infinite dose’ conditions [26 ,27 (link)], except for caffein, metoprolol, propranolol, naproxen, ranitidine, and atenolol (D0 ≤ 0.01). Individual drug solubility is further shown in results section. Metoprolol was used as a low/high BCS permeability class boundary reference drug for the Franz–PAMPA assay [28 (link)].
Samples from permeation studies were collected during 12 h (0.25; 0.5; 1.0; 2.0; 3.0; 4.0; 5.0; 6.0; 10.0, and 12.0 h) and analyzed by HPLC (Shimadzu Class VP; Kyoto, Japan or Agilent 1220, Santa Clara, CA, USA) according to official compendiums (USP 32 or Brazilian Pharmacopeia 4th edition). The sampling volume was immediately replaced with the same volume of fresh PBS prewarmed solution at 37° ± 0.5 °C. Calibration curves were performed at least at three concentration levels for each drug tested, in a GLP-accredited laboratory (Institute of Pharmaceutical Sciences, Goiânia, Goiás, Brazil). The validated chromatographic conditions used for the drug permeability assay are given in Table 1.
de Souza Teixeira L., Vila Chagas T., Alonso A., Gonzalez-Alvarez I., Bermejo M., Polli J, & Rezende K.R. (2020). Biomimetic Artificial Membrane Permeability Assay over Franz Cell Apparatus Using BCS Model Drugs. Pharmaceutics, 12(10), 988.
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Publication 2020
Atenolol Biological Assay Caffeine Cells Chromatography Diffusion High-Performance Liquid Chromatographies Membranes, Artificial Metoprolol Naproxen Permeability Pharmaceutical Preparations Phosphates Propranolol Ranitidine Tissue Donors
4
Metabolic Forest: Rapid Pathway Prediction
Cited 4 times
We built a metabolite structure predictor that rapidly enumerates trees of metabolic pathways. This algorithm–codenamed the metabolic forest—was built in python using the 2017.09.01 release of RDKIT, an open-source cheminformatics package.87 The metabolic forest included 24 reaction rules (Table 1). Each rule belonged to a ruleset, including (1) each of the five broad classes of phase I metabolism labeled in our simultaneous study,64 (link) (2) conjugation, (3) quinone formation, and (4) tautomerization. The conjugation and tautomerization rulesets encompass transformations that were sometimes implicitly included in our phase I and quinone formation datasets, perhaps due to experimental limitations.
For phase I metabolism, the stable oxygenation ruleset included the epoxidation, hydroxylation, nitrogen oxidation, and sulfur oxidation rules, the unstable oxygenation ruleset included the dealkylation and oxidation dehalogenation rules, the dehydrogenation ruleset included a lone dehydrogenation rule, the hydrolysis ruleset included the dephosphorylation, epoxide opening, carbonyl cleavage, and azo splitting rules, and the reduction ruleset included the benzodioxole reduction, dehydration, hydrogenation, nitrogen reduction, sulfur reduction, oxygen reduction, and reductive dehalogenation rules.
The conjugation ruleset included four rules specifying the reactions acetylation, glucuronidation, glutathionation, and sulfation.
The quinone formation ruleset included a single quinone formation rule that both modeled the two-electron oxidation that directly forms quinones and several types of reactions that often set the stage for that oxidation, such as aromatic hydroxylation.
Similarly, the tautomerization ruleset had a single eponymous rule. Tautomerization, although not generally regarded as a type of metabolism, nevertheless plays a role in known metabolic pathways of drugs like clopidogrel88 (link) and ranitidine.89 (link)Programmatically, these rules fell into three archetypes: SMARTS rules, resonance pair rules, and resonance structure rules, detailed in the following sections.
Hughes T.B., Dang N.L., Kumar A., Flynn N.R, & Swamidass S.J. (2020). Metabolic Forest: Predicting the Diverse Structures of Drug Metabolites. Journal of chemical information and modeling, 60(10), 4702-4716.
Publication 2020
1,4-benzoquinone Acetylation Cell Respiration Cytokinesis Dealkylation Dehydration Electrons Epoxy Compounds Forests Hydrogenation Hydrolysis Hydroxylation Hypoxia Metabolism Nitrogen Pharmaceutical Preparations Python Quinones Ranitidine Sulfur Trees Vibration
5
Gastroprotective Effects of PRLT in Mice
Cited 4 times
Kunming (KM) mice are outbreeding mice, they came from swiss mice. SPF (specific pathogen free) KM mice (six weeks old, male) were obtained from the Laboratory Animal Center, Chongqing Medical University, and raised at a temperature of 22 ± 4 °C and a humidity of 50 ± 20%. The mice were randomly divided into five groups (n = 10): normal group, control group, low-dose PRLT administrated by gavage group (PRLT-L group, 100 mg/kg), high-dose PRLT administrated by gavage group (PRLT-H group, 200 mg/kg), and ranitidine administrated by gavage group (50 mg/kg). After a one-week acclimation, normal food and drink were allowed for the mice in the normal group and control group. PRLT solutions at 100 mg/kg (0.2 mL) and 200 mg/kg (0.2 mL) were administrated by gavage in the PRLT-L group and PRLT-H group, respectively. Ranitidine solution at 50 mg/kg (0.2 mL) was administrated by gavage in the ranitidine group. The doses were given for two weeks. At Day 14, the mice were not allowed to eat but had free access to water. After fasting for 24 h, except for the mice in the normal group, other mice were administrated with inducer (60% ethanol and 40% 150 mmol/HCl) by gavage. After 30 min, all mice were dissected to collect gastric juices and gastric tissues. The eyeballs were extracted using a tweezer [22 (link)]. The gastric area was photographed, and the injury area was measured via ImageJ, based on which the inhibition rate of gastric injury by PRLT was calculated. This study was approved by the Animal Ethics Committee of Chongqing University of Education (Chongqing, China), Laboratory animal using license No. SYXK (Yu) 2018-0003.
Qian Y., Zhang J., Fu X., Yi R., Sun P., Zou M., Long X, & Zhao X. (2018). Preventive Effect of Raw Liubao Tea Polyphenols on Mouse Gastric Injuries Induced by HCl/Ethanol via Anti-Oxidative Stress. Molecules, 23(11), 2848.
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Publication 2018
Acclimatization Animal Ethics Committees Animals, Laboratory Ethanol Eye Fever Food Humidity Injuries Juices, Gastric Kunming mice Males Mice, House Mouse, Swiss Psychological Inhibition Ranitidine Specific Pathogen Free Stomach Tissues Tube Feeding

Most recents protocols related to «Ranitidine»

1
Behavioral and Histological Evaluation of Chemotherapy-Induced Gastrointestinal Disorders
Three to four months old BALB/c mice were procured from the Biogen Laboratory, Bangalore, India, and maintained in the animal house facility of Bharathidasan University. The mice were kept in an air-conditioned room at 20–22 °C with a 12-h light/dark cycle. The experimental mice were freely allowed to access standard animal feed and water. A total of 24 experimental mice were randomly divided into four groups, namely, (1) control group (N = 6), (2) cysteamine HCl group (N = 6), (3) ranitidine group (N = 6), and (4) cysteamine HCl + ranitidine group (N = 6). While mice in group 1 received normal tap water, mice in group 2 and group 4 received an intraperitoneal injection of cysteamine HCl (Sigma Aldrich, St. Louis, Missouri, USA) (60 milligrams (mg)/kilogram (Kg) body weight (BW)) for three alternate days to induce GI disorder. While a minimal dose of ranitidine can be safe and effective, in this candidate approach, the dose of ranitidine has been determined based on previous studies [36 (link)]. Thus, animals in groups 3 and 4 were orally administered ranitidine (Cadila Pharmaceuticals Limited, India) (30 mg/ Kg BW) in drinking water for 14 consecutive days. After the treatment, the experimental mice underwent behavioral experiments such as the open field test (OFT), light and dark box test (LDBT), and elevated plus maze (EPM) test. The behavioral room was equipped with a proper light setting. A video camera was placed above the center of the behavioral apparatuses. The camera was connected to a semi-automated computer system equipped with the SMART 3.0 video tracking system (Panlab, Harvard apparatus, Spain) through which digital tracking of all the animal behavioral experiments was captured (Figure 2). After the behavioral experiments, the animals were perfused, and brain tissues were processed for histology and immunostainings as earlier described by Kandasamy and colleagues [19 (link),37 (link)].
The experimental protocol involving animals was approved (Ref No. BDU/IAEC/P10/2019 dated 30.11.2019) by the Institutional Animal Ethics Committee (IAEC), Bharathidasan University under the regulation of the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), Government of India.
Selvaraj D.B., Vergil Andrews J.F., Anusuyadevi M, & Kandasamy M. (2023). Ranitidine Alleviates Anxiety-like Behaviors and Improves the Density of Pyramidal Neurons upon Deactivation of Microglia in the CA3 Region of the Hippocampus in a Cysteamine HCl-Induced Mouse Model of Gastrointestinal Disorder. Brain Sciences, 13(2), 266.
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Publication 2023
Animals Behavior Test Body Weight Brain Cysteamine Elevated Plus Maze Test Fingers Injections, Intraperitoneal Institutional Ethics Committees Light Mice, House Mice, Inbred BALB C Pharmaceutical Preparations Ranitidine Ranitidine Hydrochloride Supervision Tissues
2
Safety and Reliability of Fat Grafting in Latissimus Dorsi and Trapezius Muscles
Cited 1 time
We performed cadaveric dissections of the LD and the trapezius muscles in order to establish how safe the fat grafting procedure and how reliable the graft IM location were. Scalpel with #15/#20 blades, tissue scissors and tissue forceps were used to separate the anatomic layers; vascular retractors and markers were used to denote the main pedicles and vessels. First, we located the pedicle and then did a lipoinjection test on the contralateral virgin muscle with methylene blue to identify its proper placement at the submuscular layer for the LD (See Video 1 [online], which displays LD muscle dissection and fat grafting) and the intramuscular layer for the trapezius muscle (See Video 2 [online], which displays trapezius muscle dissection and fat grafting).
This video displays Latissimus Dorsi muscle dissection and fat grafting.1_amyckequKalturaThis video displays trapezius muscle dissection and fat grafting.1_3aphcov9KalturaThe senior author has incorporated the fat grafting technique for trapezius and LD into HD2 since 2016, so we conducted a retrospective review of our medical records from January 2016 to November 2021 at a single center (Dhara clinic) in Bogotá, Colombia. Inclusion criteria were any patient who underwent high definition liposculpture or HD2 in addition to fat grafting of either the LD or the trapezius muscles, or both. Exclusion criteria included active smokers, patients with body mass index above 32 kg/m2, patients with American Society of Anesthesiologists risk classification of III or greater. Cardiology assessment (including EKG and chest X-ray) was required for patients aged above 40 years. All patients were subject to protocols for safe large-volume liposuction, including those for thromboembolic event prevention, blood conservation, and hypothermia prevention (Tables 1–3, respectively).15 (link),16 (link),17 (link) The IV medications used were antibiotic prophylaxis with cefazolin (2 gr IV, 60 minutes prior to incision), dexamethasone 8 mg, metoclopramide 10 mg, diclofenac 50 mg, and ranitidine 50 mg. Photographic records were taken before and during follow-up at 2 days and 1, 3, 6, and 12 months after surgery.
Hoyos A.E., Stefanelli M., Perez M.E., Brenes-Leñero E, & Padilla M. (2023). Adipose Tissue Transfer in Dynamic Definition Liposculpture—PART I. Back: Latissimus Dorsi and Trapezius Muscles. Plastic and Reconstructive Surgery Global Open, 11(1), e4587.
Publication 2023
Anesthesiologist Antibiotic Prophylaxis Bladder Detrusor Muscle BLOOD Blood Vessel Cardiovascular System Cefazolin Dexamethasone Diclofenac Dissection Forceps Index, Body Mass Latissimus Dorsi Methylene Blue Metoclopramide Muscle Tissue Operative Surgical Procedures Patients Pharmaceutical Preparations Radiography, Thoracic Ranitidine Suction Lipectomy Thromboembolism Tissues Transplantation Trapezius Muscle
3
Evaluating H2 Receptor Antagonists in Septic ICU Patients
We queried the MIMIC-IV database for all adult intensive care unit (ICU) stays from 2008 to 2019. Patients 18 years or older, were included if they met the sepsis-3 criteria [22 (link)]. We acquired the following information for each patient indexed by stay ID: age, gender, and risk scores including APS III [23 (link)], SAPS II [24 (link)], SOFA [25 (link)], OASIS [26 (link)], and the Charlson comorbidity index [27 (link)]. We also extracted data on time from ICU admission to H2RA administration (if applicable), and time from ICU admission to invasive mechanical ventilation (IMV). We extracted ICU length of stay, number of days until in-hospital mortality, and in-hospital 28-day mortality. We assessed the severity of respiratory dysfunction with daily means of PaO2/FiO2 (PF ratio) over a 7-day period after admission for each patient. We further categorized the severity of pulmonary dysfunction based on the Berlin definition of acute respiratory distress syndrome, ARDS (severe ARDS: P/F ratio < 100 mmHg; moderate ARDS: P/F ratio < 200 mmHg; mild ARDS: P/F ratio < 300 mmHg) [28 (link)]. Additionally, kidney function and liver function were followed for each patient over the same 7-day period using daily means of BUN, creatinine, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Queries were performed in Google BigQuery [29 ]. Primary outcomes of interest included in-hospital mortality, ICU length of stay, and the use of IMV after day 1 of ICU stay. Secondary Outcomes included the mean P/F ratio, mean BUN/Cr ratio, AST, and ALT levels on days 1 through 7 of ICU stay. Patients were grouped by whether they had received H2RAs (ranitidine, famotidine, or cimetidine) from time of admission to 1 day of ICU stay (H2RA group) and those who did not (no H2RA group). We excluded patients who received H2RAs after day 1 of ICU admission as well as patients who were mechanically ventilated prior to receiving H2RAs. Patients with missing values in age, gender, comorbidities, or timestamps corresponding to H2RA use or mechanical ventilation (where these treatments were utilized) were also excluded.
Firzli T.R., Sathappan S., Antwi-Amoabeng D., Beutler B.D., Ulanja M.B, & Madhani-Lovely F. (2023). Association between histamine 2 receptor antagonists and sepsis outcomes in ICU patients: a retrospective analysis using the MIMI-IV database. Journal of Anesthesia, Analgesia and Critical Care, 3, 3.
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Publication 2023
Adult Aspartate Transaminase Cimetidine Creatinine CREB3L1 protein, human D-Alanine Transaminase Day Care, Medical Famotidine Gender Kidney Liver Lung Mechanical Ventilation Patients Ranitidine Respiratory Distress Syndrome, Acute Respiratory Failure Septicemia
4
Neonatal Murine Enteric Pathogen Infection

Protocol full text hidden due to copyright restrictions

Open the protocol to access the free full text link

Publication 2023
Anesthesia Animals Bacteria Brain Food Gastric Acid Infant, Newborn Infection Isoflurane Liver Milk Mothers Mus Patient Holding Stretchers Ranitidine Saline Solution Strains Tube Feeding
5
Cadaveric Dissection for Safe Intramuscular Fat Grafting
We performed cadaveric dissections of the lower limb in an attempt to support the safe and reliable approach of IM fat grafting of the muscles from the thigh and the leg. The vastus medialis, the vastus lateralis, the rectus femoris, the gastrocnemius, and the soleus muscles were all dissected following the anatomic models to locate the main pedicles and their distribution within the muscle. A scalpel with 15/20 blades, tissue scissors, and tissue forceps were used to separate the anatomic layers, vascular retractors, and markers that were used to denote the main pedicles and vessels. First, we located the pedicle, and then did a lipoinjection test on the contralateral virgin muscle with methylene blue to identify its proper placement at the IM layer for the thigh muscles and the gastrocnemius muscle. (See Video 1 [online], which displays cadaveric dissection of the thigh. Beware of the “danger triangle” where most vital structures of the thigh are located. Fat grafting of the vastus medialis and vastus lateralis muscles shows the superficial location of the graft, which is an actual premise for a safe approach.) (See Video 2 [online], which displays cadaveric dissection and fat grafting of the gastrocnemius muscle. The lateral head and the medial head have different access points to avoid the popliteal fossa, where critical neurovascular structures are present. The distal access [Achilles region] may be too close to neurovascular structures; hence, it should be avoided.)
This video displays cadaveric dissection of the thigh. Beware of the “danger triangle” where most vital structures of the thigh are located. Fat Grafting of the Vastus medialis and Vastus lateralis muscles shows the superficial location of the graft, which is an actual premise for a safe approach.1_jqhiyd6tKalturaThis video displays cadaveric dissection and fat grafting of the gastrocnemius muscle. The lateral head and the medial head have different access points to avoid the popliteal fossa where critical neurovascular structures are present. The distal access (Achilles region) may be too close to neurovascular structures, hence should be avoided.1_aclzx1xeKalturaThe senior author has incorporated the fat grafting technique for the rectus femoris, vastus medialis, vastus lateralis, and gastrocnemius muscles into dynamic definition liposculpture (HD2) since mid 2015; hence, we conducted a retrospective review of the medical records from January 2016 to May 2022 at a single center (Dhara Clinic) in Bogotá, Colombia. Inclusion criteria were any patient who underwent high definition liposculpture (HDL) or HD2 in addition to fat grafting of any muscle of the lower limb. Exclusion criteria included active smokers, patients with body mass index above 30 kg/m2, patients with PMH with blood clotting disorders or any thrombotic event (ie, DVT and PE), and patients with American Society of Anesthesiologists (ASA) risk classification of III or higher. Cardiology assessment, including EKG and chest X-ray, was required for patients older than 40 years old. All patients were subject to protocols for safe large-volume liposuction including those for thromboembolic event prevention, blood conservation, and hypothermia prevention.18 IV medications used were antibiotic prophylaxis with cefazolin (2 gr IV, 60 minutes before incision); dexamethasone, 8 mg; metoclopramide, 10 mg; diclofenac, 50 mg; and ranitidine, 50 mg. Photographic records were taken before and during follow-up at 2 days and 1, 3, 6, and 12 months after surgery.
Hoyos A.E., Stefanelli M., Perez M.E., Padilla M, & Dominguez-Millan R. (2023). Adipose Tissue Transfer in Dynamic Definition Liposculpture Part II. The Lower Limb: Gastrocnemius, Vastus Medialis, Vastus Lateralis, and Rectus Femoris Muscles. Plastic and Reconstructive Surgery Global Open, 11(1), e4765.
Publication 2023
Anesthesiologist Antibiotic Prophylaxis BLOOD Blood Coagulation Disorders Blood Vessel Cardiovascular System Cefazolin Dexamethasone Diclofenac Dissection Forceps Head Index, Body Mass Lower Extremity Methylene Blue Metoclopramide Muscle, Gastrocnemius Muscle Tissue Operative Surgical Procedures Patients Pharmaceutical Preparations Radiography, Thoracic Ranitidine Rectus Femoris Soleus Muscle Suction Lipectomy Tendon, Achilles Thigh Thromboembolism Tissues Vastus Lateralis Vastus Medialis

Top products related to «Ranitidine»

1
Ranitidine by Merck Group
Sourced in United States, United Kingdom, Germany
Ranitidine is a type of lab equipment used for the measurement and detection of specific chemical compounds. It functions as a tool to analyze and quantify the presence and concentration of these compounds in various samples.
2
Histamine by Merck Group
Sourced in United States, Germany, United Kingdom, Italy, Sao Tome and Principe, Spain, Macao, Canada, Brazil, France, Australia, Austria
Histamine is a laboratory equipment product manufactured by Merck Group. It is a chemical compound used in various research and analytical applications. Histamine plays a crucial role in biological processes and is commonly utilized in laboratories for testing and analysis purposes.
3
Fetal bovine serum (fbs) by Thermo Fisher Scientific
Sourced in United States, China, United Kingdom, Germany, Australia, Japan, Canada, Italy, France, Switzerland, New Zealand, Brazil, Belgium, India, Spain, Israel, Austria, Poland, Ireland, Sweden, Macao, Netherlands, Denmark, Cameroon, Singapore, Portugal, Argentina, Holy See (Vatican City State), Morocco, Uruguay, Mexico, Thailand, Sao Tome and Principe, Hungary, Panama, Hong Kong, Norway, United Arab Emirates, Czechia, Russian Federation, Chile, Moldova, Republic of, Gabon, Palestine, State of, Saudi Arabia, Senegal
Fetal Bovine Serum (FBS) is a cell culture supplement derived from the blood of bovine fetuses. FBS provides a source of proteins, growth factors, and other components that support the growth and maintenance of various cell types in in vitro cell culture applications.
4
β actin by Cell Signaling Technology
Sourced in United States, United Kingdom, China, Germany, Japan, Canada, Morocco, Sweden, Netherlands, Switzerland, Italy, Belgium, Australia, France, India, Ireland
β-actin is a cytoskeletal protein that is ubiquitously expressed in eukaryotic cells. It is an important component of the microfilament system and is involved in various cellular processes such as cell motility, structure, and integrity.
5
Jnj7777120 by Merck Group
Sourced in Germany, United States
JNJ7777120 is a laboratory instrument designed for scientific research and analysis. It is a versatile piece of equipment that can perform a variety of tasks in a controlled and precise manner. The core function of JNJ7777120 is to provide accurate and reliable measurements and data collection for scientific investigations.
6
Dulbecco s modified eagle s medium dmem by Thermo Fisher Scientific
Sourced in United States, China, United Kingdom, Germany, Canada, France, Australia, Japan, India, Spain, Switzerland, Israel, Italy, Belgium, Austria, New Zealand, Brazil, Argentina, Denmark, Ireland, Singapore, Egypt
Dulbecco's modified Eagle's medium (DMEM) is a cell culture medium commonly used for the in vitro cultivation of various cell types. It provides a balanced salt solution, amino acids, vitamins, and other nutrients required for cell growth and maintenance.
7
2 pyridylethylamine by Bio-Techne
Sourced in United Kingdom
2-pyridylethylamine is a chemical compound that can be used as a reagent in various laboratory applications. It serves as a building block for the synthesis of other compounds and can be utilized in research and analysis procedures. The detailed functionality and intended usage of this product should be further evaluated by qualified professionals.
8
Indomethacin by Merck Group
Sourced in United States, Germany, United Kingdom, Brazil, Italy, Sao Tome and Principe, China, India, Japan, Denmark, Australia, Macao, Spain, France, New Zealand, Poland, Singapore, Switzerland, Belgium, Canada, Argentina, Czechia, Hungary
Indomethacin is a laboratory reagent used in various research applications. It is a non-steroidal anti-inflammatory drug (NSAID) that inhibits the production of prostaglandins, which are involved in inflammation and pain. Indomethacin can be used to study the role of prostaglandins in biological processes.
9
Cimetidine by Merck Group
Sourced in United States, United Kingdom, Germany
Cimetidine is a laboratory product manufactured by Merck Group. It is a chemical compound used in various research and analytical applications.
10
Dimethyl sulfoxide (dmso) by Merck Group
Sourced in United States, Germany, United Kingdom, China, Italy, Sao Tome and Principe, France, Macao, India, Canada, Switzerland, Japan, Australia, Spain, Poland, Belgium, Brazil, Czechia, Portugal, Austria, Denmark, Israel, Sweden, Ireland, Hungary, Mexico, Netherlands, Singapore, Indonesia, Slovakia, Cameroon, Norway, Thailand, Chile, Finland, Malaysia, Latvia, New Zealand, Hong Kong, Pakistan, Uruguay, Bangladesh
DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.

More about "Ranitidine"

Ranitidine, also known by its brand name Zantac, is a histamine H2-receptor antagonist medication used to treat a variety of gastrointestinal (GI) disorders.
It works by reducing the production of stomach acid, allowing the esophagus, stomach, and duodenum to heal.
Ranitidine is commonly prescribed for the treatment of peptic ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome.
It is generally well-tolerated, with potential side effects including headache, dizziness, and constipation.
Researchers continue to explore the optimal use of ranitidine in clinical practice, as well as potential new applications and formulations.
Ranitidine has been studied in combination with other medications, such as the nonsteroidal anti-inflammatory drug (NSAID) indomethacin, and the histamine H2 antagonist cimetidine.
In addition to its use in GI disorders, ranitidine has been investigated for its potential effects on other conditions.
For example, it has been studied in the context of cell culture experiments, where it has been used alongside compounds like FBS (fetal bovine serum) and β-actin, which are common cell culture reagents.
Researchers are also exploring the use of ranitidine in combination with other medications, such as the histamine H4 receptor antagonist JNJ7777120, which may have implications for the treatment of various inflammatory and immune-related conditions.
As the research on ranitidine continues to evolve, the use of AI-driven tools, such as PubCompare.ai, can help optimize research protocols, identify the best protocols from literature, preprints, and patents, and ensure reproducibility and accuracy in Ranitidine-related studies.