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Reserpine

Reserpine is a naturally occurring indole alkaloid derived from the roots of Rauwolfia serpentina.
It is a potent antihypertensive agent that acts by depleting norepinephrine and other monoamines from sympathetic nerve endings.
Reserpine has been used to treat hypertension, psychosis, and other disorders, though its use has declined due to the availability of newer medications with fewer side effects.
Researchers may utilize PubCompare.ai's AI-driven platform to efficiently locate and compare protocols related to Reserpine from the literature, pre-prints, and patents, enhancing reproducibility in their Reserpine-focused studies.

Most cited protocols related to «Reserpine»

Metabolite Profiling by CE-TOF-MS

Cited 105 times

The metabolite standards, instrumentation and CE-TOF-MS condition were used in this study as previously described (Soga et al. 2006 (link)), with slight modifications in the lock mass system setting. All chemical standards were of analytical or reagent grade and were obtained from commercial sources. They were dissolved in Milli-Q water (Millipore, Bedford, MA, USA), 0.1 mol/l HCl or 0.1 mol/l NaOH to obtain 1, 10 or 100 mmol/l stock solutions. The working solution was prepared prior to use by diluting with Milli-Q water to the appropriate concentration.
All CE-MS experiments were performed using an Agilent CE capillary electrophoresis system (Agilent Technologies, Waldbronn, Germany), an Agilent G3250AA LC/MSD TOF system (Agilent Technologies, Palo Alto, CA, USA), an Agilent 1100 series binary HPLC pump, and the G1603A Agilent CE-MS adapter and G1607A Agilent CE-ESI-MS sprayer kit. System control and data acquisition were done with G2201AA Agilent Chemstation software for CE and Analyst QS software for TOF-MS (ver. 1.1).
All samples were measured in single mode (see below); separation was done in fused-silica capillaries (50 μm i.d. × 100 cm total length) filled with 1 M formic acid as the background electrolyte. Sample solutions were injected at 50 mbar for 3 s and a voltage of 30 kV was applied. The capillary temperature was maintained at 20°C and the temperature of the sample tray was kept below 5°C using an external thermostatic cooler. The sheath liquid, comprising methanol/water (50% v/v) and 0.5 μM reserpine, was delivered at 10 μl/min. ESI-TOF-MS was conducted in the positive ion mode. The capillary voltage was set at 4 kV; the flow rate of nitrogen gas (heater temperature 300°C) was set at 10 psig. In TOF-MS, the fragmentor, skimmer and OCT RFV voltage were set at 75, 50 and 125 V, respectively. In the present study, we used a methanol dimer adduct ion ([2MeOH + H]⁺, m/z 65.059706) and hexakis phosphazene ([M + H]⁺, m/z 622.028963) to provide the lock mass for exact mass measurements. Exact mass data were acquired at the rate of 1.5 cycles/s over a 50–1000 m/z range.

Sugimoto M., Wong D.T., Hirayama A., Soga T, & Tomita M. (2009). Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics, 6(1), 78-95.

Publication 2009

Capillaries Electrolytes Electrophoresis, Capillary formic acid High-Performance Liquid Chromatographies Methanol Nitrogen Reserpine Silicon Dioxide

Metabolite Analysis by CE-TOF-MS

Cited 96 times

Publication 2009

Capillaries Electrolytes Electrophoresis, Capillary formic acid High-Performance Liquid Chromatographies Methanol Nitrogen Reserpine Silicon Dioxide

Early Parkinson's Disease Cohort Study

Cited 48 times

PD and HC subjects of similar age and gender from 24 study sites in the US (18), Europe (5) and Australia (1) were enrolled after obtaining informed consent. We acknowledge that the early PD cohort likely includes a small number of subjects with other DAT deficit parkinsonian syndromes such as progressive supranuclear palsy (PSP), multiple system atrophy (MSA) and cortical basal syndrome (CBS), which may be indistinguishable from PD at the earliest stages of disease. At each study visit, the investigators reassess the subject diagnosis to identify any non‐PD subjects.
This study was conducted in accordance with the Declaration of Helsinki and the Good Clinical Practice (GCP) guidelines after approval of the local ethics committees of the participating sites. At enrollment, PD subjects were required to be age 30 years or older, untreated with PD medications (levodopa, dopamine agonists, MAO‐B inhibitors, or amantadine), within 2 years of diagnosis, Hoehn and Yahr <3, and to have either at least two of resting tremor, bradykinesia, or rigidity (must have either resting tremor or bradykinesia) or a single asymmetric resting tremor or asymmetric bradykinesia. All PD subjects underwent dopamine transporter (DAT) imaging with 123I Ioflupane or vesicular monoamine transporter (VMAT‐2) imaging with 18F AV133 (Australia only) and were only eligible if DAT or VMAT‐2 imaging demonstrated dopaminergic deficit consistent with PD in addition to clinical features of the disease. Study investigators evaluated enrolled PD subjects to assess absence of current or imminent (6 months) disability requiring PD medications, though subjects could initiate PD medications at any time after enrollment if the subject or investigator deemed it clinically necessary. Those subjects screened as potential PD subjects who were ineligible due to DAT or VMAT‐2 scans without evidence of dopaminergic deficit (SWEDD) were eligible to be enrolled in a SWEDD cohort.4 HC subjects were required to be age 30 years or older without an active, clinically significant neurological disorder or a first‐degree relative with PD. All enrolled subjects agreed to complete all study evaluations, including lumbar puncture.
PD and SWEDD subjects were excluded if they had a clinical diagnosis of dementia or had taken PD medications within 60 days of baseline or for longer than 60 days in total. HC subjects were excluded if they had a Montreal Cognitive Assessment (MoCA) total score ≤26. All subjects were excluded if they were treated with neuroleptics, metoclopramide, alpha methyldopa, methylphenidate, reserpine, or amphetamine derivative within 6 months or were currently treated with anticoagulants that might preclude safe completion of the lumbar puncture.

Marek K., Chowdhury S., Siderowf A., Lasch S., Coffey C.S., Caspell‐Garcia C., Simuni T., Jennings D., Tanner C.M., Trojanowski J.Q., Shaw L.M., Seibyl J., Schuff N., Singleton A., Kieburtz K., Toga A.W., Mollenhauer B., Galasko D., Chahine L.M., Weintraub D., Foroud T., Tosun‐Turgut D., Poston K., Arnedo V., Frasier M, & Sherer T. (2018). The Parkinson's progression markers initiative (PPMI) – establishing a PD biomarker cohort. Annals of Clinical and Translational Neurology, 5(12), 1460-1477.

Publication 2018

123I-ioflupane Amantadine Amphetamine Anticoagulants Antipsychotic Agents Bradykinesia Cortex, Cerebral Dementia Diagnosis Disabled Persons Dopamine Agonists Gender Hydrochloride, Dopamine Levodopa Methyldopa Methylphenidate Metoclopramide Monoamine Oxidase Inhibitors Multiple System Atrophy Muscle Rigidity Nervous System Disorder Parkinsonian Disorders Pharmaceutical Preparations Progressive Supranuclear Palsy Punctures, Lumbar Radionuclide Imaging Regional Ethics Committees Reserpine Resting Tremor SLC6A3 protein, human Syndrome Vesicular Monoamine Transport Proteins Volumetric-Modulated Arc Therapy

Lipid Extraction and LC-MS Analysis

Cited 26 times

An aliquot of 20 μl of an internal standard mixture (5 reference compounds at concentration level 83–10 μg/ml), 50 μl of 0.15 M sodium chloride and chloroform: methanol (2:1) (200 μl) was added to the tissue sample (203–30 mg). The sample was homogenized, vortexed (2 min) let to stand (1 hour for liver) and centrifuged at 10000 RPM for 3 min. From the separated lower phase, an aliquot was mixed with 10 μl of a labelled standard mixture (3 stable isotope labelled reference compounds at concentration level 93–11 μg/ml) and 0.53–1.0 μl injection was used for LC/MS analysis.
Total lipid extracts were analysed on a Waters Q-Tof Premier mass spectrometer combined with an Acquity Ultra Performance LC™ (UPLC). The column, which was kept at 50°C, was an Acquity UPLCTM BEH C18 10 × 50 mm with 1.7 μm particles. The binary solvent system (flow rate 0.200 ml/min) included A. water (1% 1 M NH₄Ac, 0.1% HCOOH) and B. LC/MS grade (Rathburn) acetonitrile/isopropanol (5:2, 1% 1 M NH₄Ac, 0.1% HCOOH). The gradient started from 65% A/35% B, reached 100% B in 6 min and remained there for the next 7 min. The total run time per sample, including a 5 min re-equilibration step, was 18 min. The temperature of the sample organizer was set at 10°C.
Mass spectrometry was carried out on Q-Tof Premier (Waters, Inc.) run in ESI+ mode. The data was collected over the mass range of m/z 3003–1600 with a scan duration of 0.08 sec. The source temperature was set at 120°C and nitrogen was used as desolvation gas (800 L/h) at 250°C. The voltages of the sampling cone and capillary were 39 V and 3.2 kV respectively and collision energy 5 V, respectively. Reserpine (50 μg/L) was used as the lock spray reference compound (10 μl/min; 10 sec scan frequency).
Data processing including peak detection, alignment, and de-isotoping, was performed using the MZmine software version 0.60 [17 (link)]. Identification was performed based on an internal reference database of lipid species. The implementation of normalization methods and data analysis were performed using Matlab version 7.2 (Mathworks, Inc.).

Sysi-Aho M., Katajamaa M., Yetukuri L, & Orešič M. (2007). Normalization method for metabolomics data using optimal selection of multiple internal standards. BMC Bioinformatics, 8, 93.

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Publication 2007

acetonitrile Capillaries Chloroform Isopropyl Alcohol Isotopes Lipids Liver Mass Spectrometry Methanol Nitrogen Radionuclide Imaging Reserpine Retinal Cone Sodium Chloride Solvents Tissues

Lipidomic Profiling of Plasma Samples

Cited 13 times

An aliquot (10 µl) of an internal standard mixture containing 11 lipid classes, and 0.05 M sodium chloride (10 µl) was added to plasma samples (10 µl) and the lipids were extracted with chloroform/methanol (2∶1, 100 µl). After vortexing (2 min), standing (1 hour) and centrifugation (10000 RPM, 3 min) the lower layer was separated and a standard mixture containing 3 labeled standard lipids was added (10 µl) to the extracts. The sample order for LC/MS analysis was determined by randomization.
Lipid extracts were analysed on a Waters Q-Tof Premier mass spectrometer combined with an Acquity Ultra Performance LC™ (UPLC). The column, which was kept at 50°C, was an Acquity UPLC™ BEH C18 10×50 mm with 1.7 µm particles. The binary solvent system included A. water (1% 1 M NH₄Ac, 0.1% HCOOH) and B. LC/MS grade (Rathburn) acetonitrile/isopropanol (5 2, 1% 1 M NH₄Ac, 0.1% HCOOH). The gradient started from 65% A/35% B, reached 100% B in 6 min and remained there for the next 7 min. The total run time including a 5 min re-equilibration step was 18 min. The flow rate was 0.200 ml/min and the injected amount 0.75 µl. The temperature of the sample organizer was set at 10°C.
The lipid profiling was carried out on Waters Q-Tof Premier mass spectrometer using ESI+ mode. The data was collected at mass range of m/z 300–1200 with a scan duration of 0.2 sec. The source temperature was set at 120°C and nitrogen was used as desolvation gas (800 L/h) at 250°C. The voltages of the sampling cone and capillary were 39 V and 3.2 kV, respectively. Reserpine (50 µg/L) was used as the lock spray reference compound (5 µl/min; 10 sec scan frequency).
Data was processed using MZmine software version 0.60 [14] (link). Lipids were identified using internal spectral library. The normalization was performed using multiple internal standards as described in the Supporting Information Text S1. Only the identified lipid molecular species were included in further data analyses.
The Supporting Information Text S1, Figures S6–23 and Tables S8–11 also include general lipidomics platform characteristics such as internal and external standards used, calibration curves, dynamic ranges, recovery, variability, identification and quality control workflow, as well as illustrative spectra (MS and MS/MS) demonstrating how the specific species can be identified.

Laaksonen R., Katajamaa M., Päivä H., Sysi-Aho M., Saarinen L., Junni P., Lütjohann D., Smet J., Van Coster R., Seppänen-Laakso T., Lehtimäki T., Soini J, & Orešič M. (2006). A Systems Biology Strategy Reveals Biological Pathways and Plasma Biomarker Candidates for Potentially Toxic Statin-Induced Changes in Muscle. PLoS ONE, 1(1), e97.

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Publication 2006

acetonitrile Capillaries cDNA Library Centrifugation Chloroform Isopropyl Alcohol Lipids Methanol Nitrogen Plasma Radionuclide Imaging Reserpine Retinal Cone Sodium Chloride Solvents Tandem Mass Spectrometry Z 300

Most recents protocols related to «Reserpine»

Metabolite Generation via HLM Incubation

For the generation of Phase I metabolites: tested compounds, at a 10 μM concentration (1 μL of 5 mM DMSO stock solution), were incubated with HLM (1 mg protein/mL), Vivid^® regenerating system (5 μL) and NADPH (1mM) in ABIC 50 mM buffer pH 7.4, for a total incubation volume of 500 μL. Incubations were run in duplicate, at 37 °C. Aliquots were collected at 0, 5, 10, 20, 30, 40, 50, 60, 75, 90, 120, 180 min and reactions were stopped by adding and ice-cold solution of reserpine (2.5 μM) in acetonitrile. Additional aliquots were taken at 0 and 120 min and subsequently treated with L-lysine (100 µM) and sodium cyanoborohydride (10 µM) or glutathione (100 µM). Following centrifugation (10,000 rpm, 15 min, RT), the clear supernatants were collected and analyzed LC-ESI-HRMS/MS. Control incubations were conducted in the same conditions: (1) using DMSO as negative control, in absence of the test drug; (2) using heat-denatured HLM (90 °C, 15 min); (3) using nevirapine, as a positive control, instead of the tested compound; and (4) in absence of NADPH co-factor.
For the generation of glucuronidation metabolites: HLM were preincubated for 15 min with alamethicin (25 µg/mL). Incubations were then run in duplicate at 37 °C, using the following conditions: test compounds at a concentration of 25 µM (1 μL of DMSO stock solution 5 mM), HLM (1 mg/mL, 10 μL), NADPH (5 mM), MgCl₂ (2 mM), UDPGA (5 mM) for a final volume of 200 μL, in 50 mM ABIC buffer pH 7.4. Control incubations were conducted in the same conditions using: (1) DMSO as negative control, in absence of the test compound; (2) heat-denatured HLM (90 °C, 15 min); and (3) in absence of UDPGA co-factor. Aliquots (50 μL) were collected at 0 and 2 h and then quenched with 50 μL of a cold 2.5 μM reserpine solution in acetonitrile. All the samples were vortexed and centrifuged for 15 min at 10,000 rpm. The supernatants were collected and stored at −20 °C until further analysis by LC-ESI-HRMS/MS.

Barcherini V., Loureiro J.B., Sena A., Madeira C., Leandro P., Saraiva L., Antunes A.M, & Santos M.M. (2023). Metabolism-Guided Optimization of Tryptophanol-Derived Isoindolinone p53 Activators. Pharmaceuticals, 16(2), 146.

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Publication 2023

acetonitrile Alamethicin Buffers Centrifugation Cold Temperature Glutathione Lysine Magnesium Chloride NADP Nevirapine Proteins Reserpine sodium cyanoborohydride Substance Abuse Detection Sulfoxide, Dimethyl Uridine Diphosphate Glucuronic Acid

Plasma Stability Evaluation of Compounds

Human plasma incubations were performed in duplicate, at 37 °C, by standard methodology [49 (link)]. Specifically, incubations contained 40 μM of the test compound for a final volume of 1 mL. The mixtures were incubated for a total time of 24 h, and aliquots following 0, 30, 60, 120, 180 min and 24 h and quenched with a cold solution of reserpine 0.1 mM in acetonitrile. Following centrifugation (10,000 rpm, 10 min, RT), the clear supernatants were collected and analyzed by LC-ESI(+)-MS/MS. Additional control assays were conducted using PBS pH 7.4 instead of plasma solution and using procaine as a positive control.

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Publication 2023

acetonitrile Biological Assay Centrifugation Common Cold Homo sapiens Plasma Procaine Reserpine Tandem Mass Spectrometry

In Vitro Metabolic Stability Assay

Tested compounds at a 10 μM concentration (1 μL of 5 mM DMSO stock solution) were incubated with rat liver S9 fraction (2 mg protein/mL), Vivid^® regenerating system (2 μL) and NADPH (1mM) in ABIC 50 mM buffer pH 7.4, for a total incubation volume of 500 μL. Incubations were run in duplicate at 37 °C. Additional incubation was run using the same conditions in the presence of glutathione (1 mM). Incubations were run in duplicate at 37 °C. Aliquots were collected at 0, 5, 10, 20, 30, 40, 50, 60, 75, 90, 120, 180 min and reactions were terminated by adding an ice-cold solution of reserpine (2.5 μM) in acetonitrile. Following centrifugation (10,000 rpm, 15 min, RT) the clear supernatants were collected and analyzed LC-ESI-HRMS/MS. Control incubations were conducted in the same conditions: (1) using DMSO as negative control, in absence of the test drug; (2) using heat-denatured HLM (90 °C, 15 min); (3) using nevirapine, as a positive control, instead of the tested compound; and (4) in absence of NADPH co-factor

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Publication 2023

acetonitrile Buffers Centrifugation Cold Temperature Glutathione Liver NADP Nevirapine Proteins Reserpine Substance Abuse Detection Sulfoxide, Dimethyl

LC-MS Characterization of C. tomentosum Acetone Extract

Acetone extract of C. tomentosum was characterized using LC-MS instrument (LC-MS-2020, Shimadzu Scientific Instruments, Tokyo, Japan). The instrument was equipped with an electrospray ionization (ESI) source operating in negative and positive modes (m/z 100–1200), nebulizing gas (1.5 ℓ/min), DL temperature (250 °C), heat block temperature (200 °C) and detector voltage (0.19 Kv). The chromatographic system consisted of a reversed-phase shim-pack C₁₈ column (5 µm, 250 mm × 2.1 internal diameter) maintained at a constant temperature (30 °C) using an oven. The mobile phase comprises mixture A (10-mM ammonium formate in 90% acetonitrile: water, v/v) and mixture B (0.1% formic acid in acetonitrile, v/v). The extract was dissolved in LC-MS-grade acetonitrile and 2.0 µL was injected into the chromatographic system. An isocratic elution was achieved with 30% mixture A and 70% mixture B at a flow rate of 200 µL/min [65 (link)]. Authenticated chemical standards (reserpine and nitrophenol) were analyzed at the same chromatographic conditions to calibrate and tune the MS. Water, ammonium formate and acetonitrile used to prepare mobile phase were of LC, UV grade and LC-MS grade (Macron, fine chemicals). Data acquisition and MS spectral analysis were executed using LabSolution software (Shimadzu) and recorded as absolute intensity and m/z values. The phytochemicals in the acetone extract of C. tomentosum were tentatively identified by exporting MS data (m/z values and corresponding absolute intensities) for each peak and loading into m/z cloud software to search for possible compounds matching the MS fingerprint in the library (HighChem LLC, 2013–2020). The compounds with the highest best match percentage were recorded.

Asong J.A., Frimpong E.K., Seepe H.A., Katata-Seru L., Amoo S.O, & Aremu A.O. (2023). Green Synthesis of Characterized Silver Nanoparticle Using Cullen tomentosum and Assessment of Its Antibacterial Activity. Antibiotics, 12(2), 203.

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Publication 2023

Acetone acetonitrile cDNA Library Chromatography formic acid formic acid, ammonium salt Nitrophenols Phytochemicals Reserpine SHIMS Z-100

Precise Analytical Procedures for Compound Identification

All aqueous solutions were prepared with deionized water (Millipore Milli‐Q; Sigma Aldrich, St. Louis, MO, USA). LC‐MS‐Grade methanol (MeOH) and acetonitrile (ACN) were purchased from Honeywell (Charlotte, NC, USA). Formic acid (FA) for the electrospray was purchased from Fisher Scientific (Waltham, MA, USA). Caffeine, reserpine, and leucine enkephalin were purchased from Sigma Aldrich. ESI‐L Low Concentration Tuning Mix and 0.5 ml 96‐well plates were bought from Agilent Technologies (Santa Clara, CA, USA).

Arciniega C., Garrard K.P., Guymon J.P., Manni JG S.r., Apffel A., Fjeldsted J.C, & Muddiman D.C. (2023). Quasi‐continuous infrared matrix‐assisted laser desorption electrospray ionization source coupled to a quadrupole time‐of‐flight mass spectrometer for direct analysis from well plates. Journal of Mass Spectrometry, 58(1), e4902.

Publication 2023

acetonitrile Caffeine Enkephalin, Leucine formic acid Methanol Reserpine

Top products related to «Reserpine»

Reserpine by Merck Group

Sourced in United States, Germany, United Kingdom, Canada, Macao, India

Reserpine is a compound used in laboratory settings. It is a naturally occurring alkaloid compound extracted from the roots of certain Rauwolfia plant species. Reserpine is primarily utilized as a research tool in various scientific investigations, but its specific core function and applications should be determined by the user's research objectives and requirements.

Verapamil by Merck Group

Sourced in United States, Germany, France, United Kingdom, China, Japan, Spain, Italy, Sao Tome and Principe, Switzerland, Australia, Ireland, Belgium

Verapamil is a laboratory product manufactured by Merck Group. It is a calcium channel blocker that inhibits the movement of calcium ions through cell membranes, which can affect various physiological processes. The core function of Verapamil is to serve as a research tool for the study of calcium-dependent mechanisms in biological systems.

Hoechst 33342 by Merck Group

Sourced in United States, Germany, Italy, United Kingdom, Japan, China, France, Sao Tome and Principe, Canada, Macao, Belgium, Israel, Spain, Australia, Poland, Switzerland, India, Denmark, Austria, Netherlands

Hoechst 33342 is a fluorescent dye that binds to DNA. It can be used to visualize and quantify nucleic acids in various applications such as flow cytometry, fluorescence microscopy, and nucleic acid staining.

Dimethyl sulfoxide (dmso) by Merck Group

Sourced in United States, Germany, United Kingdom, China, Italy, Sao Tome and Principe, France, Macao, India, Canada, Switzerland, Japan, Australia, Spain, Poland, Belgium, Brazil, Czechia, Portugal, Austria, Denmark, Israel, Sweden, Ireland, Hungary, Mexico, Netherlands, Singapore, Indonesia, Slovakia, Cameroon, Norway, Thailand, Chile, Finland, Malaysia, Latvia, New Zealand, Hong Kong, Pakistan, Uruguay, Bangladesh

DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.

Formic acid by Merck Group

Sourced in Germany, United States, Italy, United Kingdom, France, Spain, China, Poland, India, Switzerland, Sao Tome and Principe, Belgium, Australia, Canada, Ireland, Macao, Hungary, Czechia, Netherlands, Portugal, Brazil, Singapore, Austria, Mexico, Chile, Sweden, Bulgaria, Denmark, Malaysia, Norway, New Zealand, Japan, Romania, Finland, Indonesia

Formic acid is a colorless, pungent-smelling liquid chemical compound. It is the simplest carboxylic acid, with the chemical formula HCOOH. Formic acid is widely used in various industrial and laboratory applications.

Reserpine by Bio-Techne

Sourced in United Kingdom

Reserpine is a laboratory product manufactured by Bio-Techne. It is a naturally occurring alkaloid compound that acts as a potent inhibitor of vesicular monoamine transporters (VMAT).

Milli q system by Merck Group

Sourced in United States, Germany, France, United Kingdom, Italy, Morocco, Spain, Japan, Brazil, Australia, China, Belgium, Ireland, Denmark, Sweden, Canada, Hungary, Greece, India, Portugal, Switzerland

The Milli-Q system is a water purification system designed to produce high-quality ultrapure water. It utilizes a multi-stage filtration process to remove impurities, ions, and organic matter from the input water, resulting in water that meets the strict standards required for various laboratory applications.

Reserpine by Nacalai Tesque

Sourced in Japan

Reserpine is a laboratory reagent used in the study of various biological and biochemical processes. It is a phytochemical compound derived from the roots of the Rauwolfia serpentina plant. Reserpine is commonly used as a research tool to investigate the mechanisms of action and effects of certain drugs and neurotransmitters.

Acetonitrile by Merck Group

Sourced in Germany, United States, Italy, India, China, United Kingdom, France, Poland, Spain, Switzerland, Australia, Canada, Brazil, Sao Tome and Principe, Ireland, Belgium, Macao, Japan, Singapore, Mexico, Austria, Czechia, Bulgaria, Hungary, Egypt, Denmark, Chile, Malaysia, Israel, Croatia, Portugal, New Zealand, Romania, Norway, Sweden, Indonesia

Acetonitrile is a colorless, volatile, flammable liquid. It is a commonly used solvent in various analytical and chemical applications, including liquid chromatography, gas chromatography, and other laboratory procedures. Acetonitrile is known for its high polarity and ability to dissolve a wide range of organic compounds.

Microplate reader by Agilent Technologies

Sourced in United States, China, Germany, Japan, United Kingdom, France, Australia, Switzerland, Ireland, Canada, India, Mongolia, Hong Kong

The Microplate reader is a versatile laboratory instrument used to measure and analyze the optical properties of samples in microplates. It is designed to quantify absorbance, fluorescence, or luminescence signals from various assays and applications.

More about "Reserpine"

Reserpine is a naturally occurring alkaloid derived from the roots of the Rauwolfia serpentina plant.
This potent antihypertensive agent works by depleting norepinephrine and other monoamines from sympathetic nerve endings.
Historically, Reserpine has been used to treat conditions like hypertension, psychosis, and various other disorders, though its use has declined due to the availability of newer medications with fewer side effects.
Researchers can leverage PubCompare.ai's AI-driven platform to efficiently locate and compare protocols related to Reserpine from the literature, pre-prints, and patents.
This can help enhance reproducibility in their Reserpine-focused studies.
The platform allows researchers to easily find and compare relevant protocols, as well as identify the best products and procedures for their experiments.
In addition to Reserpine, researchers may also be interested in exploring other related compounds like Verapamil, a calcium channel blocker, or Hoechst 33342, a fluorescent dye used for cell staining.
The use of solvents like DMSO, formic acid, and Milli-Q purified water, as well as analytical techniques like microplate readers, may also be relevant in Reserpine-related research.
By utilizing PubCompare.ai's AI-powered tools and leveraging the insights from the literature, researchers can streamline their Reserpine-focused studies, improve their research efficiency, and ultimately enhance the reproducibility of their findings.
This can lead to more robust and reliable results, contributing to the advancement of our understanding of Reserpine and its applications.