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Rocuronium

Rocuronium is a nondepolarizing neuromuscular blocking agent used in anesthesia and critical care to facilitate intubation and provide muscle relaxation during surgical procedures.
It acts by competitively antagonizing acetylcholine at the neuromuscular junction, resulting in reversible paralysis of skeletal musles.
Rocuronium has a rapid onset of action and intermediate duration of effect, making it a commonly used neuromusclar blocker.
PubCompare.ai can help researchers optimize Rocuronium protacols by comparing the most efficent procedures from published literature, preprints, and patents.

Most cited protocols related to «Rocuronium»

1
Pre-hospital Airway Management in Denmark
The Central Denmark Region covers a mixed urban and rural area of approximately 13000 km2with a population of 1.27 million. The overall population density is 97.7 inhabitants pr. km2.
The standard EU emergency telephone number (1-1-2) covers all Denmark and there is an Emergency Medical Dispatch Centre in each of the five Danish regions. Emergency Medical Dispatch is criteria based.
The Central Denmark Region has a two-tiered EMS system. The first tier consists of 64 ground ambulances staffed with Emergency Medical Technicians (EMTs) on an intermediate or paramedic level (EMT-I / EMT-P). EMTs in The Central Denmark Region do not perform PHETI, nor do they use supraglottic airway devices (SADs).
The second tier consists of ten pre-hospital critical care teams staffed with an anaesthesiologist (with at least 4½ years’ experience in anaesthesia) and a specially trained EMT. Nine of the pre-hospital critical care teams are deployed by rapid response vehicles; the tenth team staffs a HEMS helicopter.
In the most rural parts of the region there are three rapid response vehicles staffed with an EMT and an anaesthetic nurse. The anaesthetic nurses do not use SADs nor do they perform Rapid Sequence Intubation (RSI) or other forms of drug-assisted PHAAM in the pre-hospital setting. These rapid response vehicles were not part of this study.
The pre-hospital critical care teams covered by this study employ approximately 90 anaesthesiologists as part time pre-hospital physicians. There are no full-time pre-hospital critical care physicians in the region – all physicians primarily work in one of the five regional emergency hospitals or at the university hospital. All pre-hospital critical care physicians have in-hospital emergency anaesthesia and advanced airway management both in- and outside the operating theatre as part of their daily work. Intensive care is part of the Danish anaesthesiological curriculum.
All pre-hospital critical care teams carry the same equipment for airway management. This includes equipment for bag-mask-ventilation (BMV), endotracheal tubes and standard laryngoscopes with Macintosh blades (and Miller blades for infants and neonates), intubation stylets, AirTraq™ laryngoscopes, Gum-Elastic Bougies, standard laryngeal masks (LMAs), intubating laryngeal masks (ILMAs) and equipment for establishing a surgical airway. All units are equipped with a capnograph and an automated ventilator. The pre-hospital critical care teams carry a standardised set-up of medications including thiopental, propofol, midazolam and s-ketamine for anaesthesia and sedation, alfentanil, fentanyl and morphine for analgesia and suxametonium and rocuronium as neuro-muscular blocking agents (NMBAs). Lidocain is available for topical anaesthesia.
Our system has no airway management protocols or standard operating procedures (SOPs) regarding PHAAM or pre-hospital RSI [22 (link)] and the physicians use the available drugs and equipment at their own discretion.
The pre-hospital critical care anaesthesiologists in our region have an average of 17.6 years of experience in anaesthesia and on average 7.2 years of experience with pre-hospital critical care. The average pre-hospital critical care physician performs 14.5 endotracheal intubations per month, 1 of them in the pre-hospital setting.
We have previously reported details of the pre-hospital critical care physicians’ education, training, level of experience and equipment-awareness in our region [22 (link)].
We collected data from February 1st 2011 until November 1st 2012.
Follow-up data regarding 30-days mortality were collected in January and February 2013.
Rognås L., Hansen T.M., Kirkegaard H, & Tønnesen E. (2013). Pre-hospital advanced airway management by experienced anaesthesiologists: a prospective descriptive study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 21, 58.
Publication 2013
Airway Management Alfentanil Ambulances Anesthesia Anesthesiologist Anesthetics Awareness Capnography Cardiac Arrest Critical Care Emergencies Emergency Medical Dispatch Emergency Medical Technicians Fentanyl Hemorrhage Infant Infant, Newborn Intensive Care Intubation Intubation, Intratracheal Ketamine Laryngeal Masks Laryngoscopes Lidocaine Management, Pain Medical Devices Midazolam Morphine Muscle Tissue Nurses Operative Surgical Procedures Paramedical Personnel Pharmaceutical Preparations Physicians Propofol Rapid Sequence Intubation Rocuronium Sedatives Temporal Lobe Thiopental Topical Anesthetics
2
Nociceptive Responses in Laparoscopic vs. Open Surgery
Using this hemodynamic model for nociceptive responses, we prospectively evaluated the differences in nociceptive responses just after skin incision between laparoscopic surgery (n=10) and open abdominal surgery (n=10). All eligible patients underwent laparoscopic or open gastrectomy (n=5 or 4), otherwise, laparoscopic or open hysterectomy (n=5 or 6) in 2017. General anesthesia was induced with propofol (1.5 mg/kg), fentanyl (2 μg/kg), and 1 MACage of desflurane. Rocuronium (0.9 mg/kg) was injected intravenously to facilitate endotracheal intubation. Mechanical ventilation was performed using an oxygen concentration of 40% to obtain normocapnia (end-tidal carbon dioxide range 35–40 mmHg). After induction, anesthesia was maintained with 0.7 MACage of desflurane. Intravenous remifentanil (0.04–0.05 μg/kg/min) was continuously infused to keep the effect site concentration at 1.0 ng/mL before and after the start of skin incision. Peripheral nerve blocks were not performed. Three variables of HR, SBP, and PI were recorded before, 0.5 min, and 1 min after the skin incision. Nociceptive responses were then calculated from the developed hemodynamic model using computer software (Microsoft Excel, Microsoft, Redmond, WA) to determine whether this model discerns between nociceptive levels during small skin incision for laparoscopic surgery vs. large skin incision for open abdominal surgery. Vasoactive agents were not administered until 1 min after the skin incision. At 1 min after the skin incision, the continuous dose of remifentanil was increased to 0.1–0.5 μg/kg/min with additional intravenous fentanyl to suppress any further increase in nociceptive responses.
To calculate MACage, which is the MAC for a given age normalized to MAC40 [14 (link)], we used MAC40 as 2.0 for sevoflurane and 6.0 for desflurane [15 ] to calculate MACage.
Hirose M., Kobayashi Y., Nakamoto S., Ueki R., Kariya N, & Tatara T. (2018). Development of a Hemodynamic Model Using Routine Monitoring Parameters for Nociceptive Responses Evaluation During Surgery Under General Anesthesia. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 24, 3324-3331.
Publication 2018
Abdomen Anesthesia Carbon dioxide Desflurane Fentanyl Gastrectomy General Anesthesia Hemodynamics Hysterectomy Intubation, Intratracheal Laparoscopy Mechanical Ventilation Nerve Block Operative Surgical Procedures Oxygen Patients Propofol Remifentanil Rocuronium Sevoflurane Skin Surgical Wound
3
Sedation, Paralysis, and Ventilation Dynamics
The study protocol consisted of two consecutive parts. In the first part (step one), the patients were deeply sedated and paralyzed. The anesthesia was maintained with infusion of propofol 1 % (200–300 γ/Kg/min) and paralysis with rocuronium (a bolus of 0.8 mg/kg at the begin and subsequently 20 mg every 20 min) to obtain a total myorelaxation. Sedation was titrated to obtain a state equivalent to a Richmond Agitation Sedation Score (RASS) of −5. A tidal volume of 6–8 ml/Kg of predicted body weight was applied during volume-controlled ventilation.
Subsequently in the second part (step two), after about 60 min from the end of the first part, patients were maintained sedated without paralysis and ventilated in pressure support ventilation to insure a tidal volume similar to that of volume-controlled ventilation. Sedation was titrated to obtain a RASS between −3 and −2. Patients were always maintained in supine position at 0° for the entire study. Because the most of the patients were enrolled in intensive care unit after elective general anesthesia (i.e., already sedated and paralyzed), the first and the second parts of the study were not performed in a random fashion and the sedation and paralysis step was always done first. However, the measurements collected in the four different study conditions both during controlled and pressure support ventilation were taken in a random fashion as follows:

PEEP 0 cmH2O with esophageal balloon placed at 25–30 cm from the mouth (middle position)

PEEP 0 cmH2O with esophageal balloon placed at 40–45 cm from the mouth (low position)

PEEP 10 cmH2O with esophageal balloon placed at 25-30 cm from the mouth (middle position)

PEEP 10 cmH2O with esophageal balloon placed at 40–45 cm from the mouth (low position)

Two-min recording sections were taken for each condition after a stabilization period (10 min) following the change in PEEP level and esophageal balloon position. A schematic overview of the protocol is shown in Fig. 1.

Schematic overview of the study protocol

Chiumello D., Consonni D., Coppola S., Froio S., Crimella F, & Colombo A. (2016). The occlusion tests and end-expiratory esophageal pressure: measurements and comparison in controlled and assisted ventilation. Annals of Intensive Care, 6, 13.
Publication 2016
Anesthesia Body Weight General Anesthesia One-Step dentin bonding system Oral Cavity Patients Positive End-Expiratory Pressure Pressure Propofol Rocuronium Sedatives Tidal Volume
4
Quadratus Lumborum Block for Anesthesia
Invasive radial arterial blood pressure, heart rate (HR), electrocardiogram (ECG), percutaneous oxygen saturation (SpO2), and bispectral index (BIS) were routinely monitored after the patients entered to the operating room. Peripheral intravenous access and right central vein access were established. Prior to anesthesia induction, patients in both groups received ultrasound-guided bilateral QLB in the lateral position. Following disinfection of the intervention area, a convex probe (2–5 HZ, Edge, Sonosite, Seattle, USA) was positioned on the anterosuperior iliac crest and moved cranially until the external oblique, internal oblique, and transversus abdominis were identified. Then, the probe was moved posteriorly, and the quadratus lumborum muscle was observed. A 22 gauge × 80 mm needle (Kindly, Shanghai, China) was inserted into the posterior part of the QL muscle. After confirming the optimal site by hydrodissection, group Q was injected with 20 mL of 0.3 % ropivacaine (Naropin, AstraZeneca AB Company, Södertälje, Sweden), and group C was injected with 20 mL of 0.9 % saline on each side. Posterior spread was observed (Fig. 2). After the block, the dermatomes of the sensory block at the 15th minutes were evaluated using pinprick for all subjects.

Ultrasonographic image of QLB. Arrow shows the direction of needle. EO, external oblique muscle; IO, internal oblique muscle; TA, transversus abdominis; QL, quadratus lumborum; PM, psoas major; ES, erector spinae

After QLB, 0.02–0.03 mg/kg midazolam, 0.3–0.4 µg/kg sufentanil, 1.5–2 mg/kg propofol, and 0.6–0.8 mg/kg rocuronium were administered intravenously for anesthesia induction. Mechanical ventilation was performed by volume-controlled ventilation after intubation to maintain the end-tidal carbon dioxide pressure (PetCO2) at 30–40 mmHg. Anesthesia was maintained with propofol 0.1–0.2 mg/kg/min and remifentanil 0.2–0.3 µg/kg/min to maintain a BIS of 40–60. Fluid and vasoactive drugs were administered to maintained intraoperative haemodynamics within the appropriate range during surgery by experienced anesthesiologists. Following surgery, 0.15 µg/kg sufentanil and parecoxib 40 mg IV were used for postoperative analgesia. A patient-controlled intravenous analgesia pump with sufentanil was administered to all patients after being transferred to the recovery room.
Zhu M., Qi Y., He H., Zhang S, & Mei Y. (2021). Effect of quadratus lumborum block on postoperative cognitive function in elderly patients undergoing laparoscopic radical gastrectomy: a randomized controlled trial. BMC Geriatrics, 21, 238.
Publication 2021
Anesthesia Anesthesiologist Carbon dioxide Disinfection Electrocardiography External Abdominal Oblique Muscle Hemodynamics Iliac Crest Internal Abdominal Oblique Muscle Intubation Management, Pain Mechanical Ventilation Midazolam Muscle, Back Muscle Tissue Naropin Needles Normal Saline Operative Surgical Procedures Oxygen Saturation parecoxib Patient-Controlled Analgesia Patient Monitoring Patients Pharmaceutical Preparations Pressure Propofol Rate, Heart Remifentanil Rocuronium Ropivacaine Saturation of Peripheral Oxygen Sufentanil Transversus Abdominis Ultrasonography Veins
5
Awake Fiberoptic Intubation for Cervical Spine Injury
After approval of the protocol by the Institutional Review Board, 50 adult patients with traumatic cervical spine injury undergoing cervical spine fixation surgery were recruited for the study over a period of 12 months. A written informed consent was obtained from each patient. Uncooperative patients, those allergic to LA, asthmatics, epileptics and those with deranged coagulation, hemodynamic instability, bradyarrhythmias, or infection at the local site were excluded from the study.
A thorough preoperative evaluation including a complete airway evaluation (mouth opening, mallampati grading, thyromental distance, and evaluation of dentition) was performed. Standard fasting guidelines and anti-aspiration prophylaxis with tablet ranitidine 150 mg were prescribed. The patients were explained about the awake FOB guided intubation during preoperative assessment. Injection glycopyrrolate 5 μg/kg was given intramuscularly half an hour before shifting the patient to the operating room (OR). Inside the OR, standard monitoring, including electrocardiography (ECG), noninvasive blood pressure (BP), and pulse oximetry (SpO2) were applied in all patients. An intravenous (IV) line was secured and ringer lactate was started. An arterial line was established under local anesthesia. After recording the baseline heart rate (HR), BP and SpO2, injection midazolam 20 μg/kg and injection fentanyl 1 μg/kg were given IV.
The patients were randomly allocated into two groups. Randomization was done using computer generated tables of random numbers. Group L (n = 25) received 10 ml of 4% lignocaine by ultrasonic nebulizer (LD 10185, Honsun, Shanghai, China) for 15 min, and Group NB (n = 25) received bilateral superior laryngeal nerve and transtracheal instillation of 2 ml of 2% lignocaine, along with viscous xylocaine gargles twice. Adequate effect of local anesthesia was confirmed by heaviness of tongue in Group L patients and by hoarseness of voice in Group NB patients.
While giving supplemental oxygen through nasal prongs, FOB guided intubation was performed. Size 8.0 mm internal diameter endotracheal tube was used for male patients and 7.5 mm for female patients. Vital parameters (HR, BP, and SpO2) were also recorded during intubation and at 1 min and 3 min postintubation. Supplemental LA was given as 1 ml aliquots of 2% lignocaine through the working channel of FOB (next aliquot given only after waiting for 30-60 s). Other parameters such as gag/cough reflex, cord visibility (relaxed, partially relaxed or adducted on endoscopic view), and ease of intubation [Table 1] were also recorded. Any signs of lignocaine toxicity such as ECG changes, seizures, and bronchoconstriction were also noted. After the airway was secured, general anesthesia was administered with propofol 2 mg/kg, and rocuronium 0.6 mg/kg. Postoperatively, patient comfort was assessed for complete amnesia, partial recall, and unpleasant memories during awake FOB guided intubation.
All data were tabulated and analyzed statistically. Parametric values were reported as mean ± standard deviation. Hemodynamic variables were compared using the unpaired Student's t-test. Intubation grades and patient comfort scores were compared using the Mann — Whitney U test. Statistical significant value was considered if P < 0.05.
Gupta B., Kohli S., Farooque K., Jalwal G., Gupta D., Sinha S, & C.h.a.n.d.r.a.l.e.k.h.a. (2014). Topical airway anesthesia for awake fiberoptic intubation: Comparison between airway nerve blocks and nebulized lignocaine by ultrasonic nebulizer. Saudi Journal of Anaesthesia, 8(Suppl 1), S15-S19.
Publication 2014
Adult Amnesia Anesthetic Effect Arterial Lines Asthma Blood Pressure Bronchoconstriction Cervical Vertebrae Coagulation, Blood Cone-Rod Dystrophy 2 Cough Electrocardiography Endoscopy Epilepsy Ethics Committees, Research Fentanyl General Anesthesia Glycopyrrolate Hemodynamics Hoarseness Infection Injuries Intubation Lactated Ringer's Solution Lidocaine Local Anesthesia Males Memory Mental Recall Midazolam Mouthwashes Nebulizers Nose Operative Surgical Procedures Oral Cavity Oximetry, Pulse Oxygen Patients Propofol Ranitidine Rate, Heart Rocuronium Saturation of Peripheral Oxygen Seizures Superior Laryngeal Nerves Tablet Tongue Tooth Ultrasonics Viscosity Woman Xylocaine

Most recents protocols related to «Rocuronium»

1
Anesthetic Management for Thoracic Surgery
All patients received general anesthesia, either alone or in combined with regional nerve block (including paravertebral nerve block, epidural anesthesia, and intercostal nerve block.) according to the type of surgery. Patients underwent lobectomy or sublobectomy according to surgeon’s comprehensive evaluation based on patient’s condition.
Anesthesia induction used propofol and/or etomidate, sufentanil, and rocuronium or cisatracurium. Anesthesia maintenance used sevoflurane or propofol combined with remifentanil or sufentanil. Rocuronium or cisatracurium was used to maintain muscle relaxation. Supplemental drugs such as flurbiprofen axetil were administered when necessary. The aim was to maintain BIS 40-60, blood pressure within 20% of baseline, and temperature 36-37°C.
Double-lumen endotracheal tube of sizes Ch33-39 was used for lung isolation according to patient height. The ventilation mode was volume control mode with 6-8 ml/kg of tidal volume (TV) during two-lung ventilation and 5-6 ml/kg during one-lung ventilation (OLA), and 0-5 cmH2O of positive end-expiratory pressure (PEEP), and 12-20 breaths/min of respiratory rates. The aim was to maintain PETCO2 35-45 mmHg and SpO2 ≥92%. At the end of anesthesia, neostigmine was used to antagonize muscular relaxant before extubation.
Fluid infusion was administrated with crystalloid at a rate of 4–6 mL/kg-1h-1. Colloids or blood product was used according to anesthesiologist’s comprehensive evaluation based on patient’s condition. Patient-controlled intravenous analgesia was used after surgery for postoperative analgesia to maintain numeric rating scales (NRS) ≤ 3 scores.
Jin F., Liu W., Qiao X., Shi J., Xin R, & Jia H.Q. (2023). Nomogram prediction model of postoperative pneumonia in patients with lung cancer: A retrospective cohort study. Frontiers in Oncology, 13, 1114302.
Publication 2023
Anesthesia Anesthesiologist BLOOD Blood Pressure cisatracurium Colloids Epidural Anesthesia Etomidate flurbiprofen axetil General Anesthesia isolation Lung Management, Pain Muscle Tissue Neostigmine Nerve Block One-Lung Ventilation Operative Surgical Procedures Patient-Controlled Analgesia Patients Pharmaceutical Preparations Positive End-Expiratory Pressure Propofol Relaxations, Muscle Remifentanil Respiratory Rate Rocuronium Saturation of Peripheral Oxygen Sevoflurane Solutions, Crystalloid Sufentanil Surgeons Tidal Volume Tracheal Extubation
2
Standardized Clinical Anesthesia Protocol
All procedures were finished under general anesthesia following a standardized clinical routine. Routine monitoring of electrocardiogram, blood pressure, and pulse oximetry were carried out. General anesthesia was induced with propofol, remifentanil, and rocuronium, and the dosage of drugs depended on the body weight of the patient. The maintenance of anesthesia was implemented by the use of remifentanil and propofol, oxygen, and air (26 (link)). In accordance with the PONV prevention guidelines, we routinely provided dexamethasone and palonosetron at the end of surgery (13 (link), 27 (link)).
Song Y., Zhu J., Dong Z., Wang C., Xiao J, & Yang W. (2023). Incidence and risk factors of postoperative nausea and vomiting following laparoscopic sleeve gastrectomy and its relationship with Helicobacter pylori: A propensity score matching analysis. Frontiers in Endocrinology, 14, 1102017.
Publication 2023
Anesthesia Blood Pressure Body Weight Dexamethasone Electrocardiogram General Anesthesia Operative Surgical Procedures Oximetry, Pulse Oxygen Palonosetron Patients Pharmaceutical Preparations Postoperative Nausea and Vomiting Propofol Remifentanil Rocuronium
3
Anesthesia and Vital Sign Monitoring in Pigs
To begin, sedative drugs were delivered through an intramuscular injection of Sumianxin (0.2ml/kg) and 3% phenobarbital (1ml/kg). It took about 5-10 minutes for the pig to fall asleep. The vein channel was established through the ear vein, and the intravenous indwelling needle was inserted. 8-10ml of general anesthesia drug was injected (propofol injection, 2mg/kg, Fentanyl citrate injection, 2ug/kg, Rocuronium injection, 1mg/kg). Endotracheal intubation was performed with an insertion depth of about 28cm. After successful intubation, a ventilator was connected, and anesthetics were given continuously. The vital signs such as respiration, heart rate, and electrocardiogram were observed.
Zhang C., Feng J., Liu Y., Zhang Y., Song W., Ma Y., Han X, & Wang G. (2023). Direct and indirect damage zone of radiofrequency ablation in porcine lumbar vertebra. Frontiers in Oncology, 13, 1138837.
Publication 2023
Anesthetics Anesthetics, General Cell Respiration Electrocardiography Fentanyl Citrate Intramuscular Injection Intubation Intubation, Intratracheal Needles Phenobarbital Propofol Rate, Heart Rocuronium Signs, Vital Tranquilizing Agents Veins
4
Cell Saver Use in Cardiac Surgery
Cell Saver use was performed in strict accordance with standard procedures. In this experiment, a Cell Saver Elite (Haemonetics, USA) was used in the operation. Heparinized saline solution with 25.000 IU of heparin in 1 L of 0.9% saline solution at a rate of 100 ml/h was used to prevent thrombogenesis during blood collection. During non-heparinized periods, any blood shed from the wound and mediastina was heparinized and drawn into the reservoir of the CS device via negative pressure (<150 mmHg). Salvaged blood was then filtered, centrifuged, washed, and concentrated to sRBCs that were transfused back into the patient as appropriate (9 (link)). For patients who need CPB, the target flow rate was 2.4 L/(m2/min), and CPB was initiated when the activated clotting time (ACT) was greater than 480 s. When the patient’s temperature had reached 36°C, they were gradually weaned off of CPB and protamine was used at a 1:1 ratio to neutralize heparin. After CPB, the residual blood in the pipeline and CPB is also washed by CS and returned to the patient. Intravenous rocuronium, sufentanil, propofol, and midazolam were used for anesthesia induction, whereas maintenance anesthesia throughout the procedure consisted of sufentanil, pipecuronium, and midazolam. RBCs transfusion during CPB is jointly decided by the surgeon, anesthetist, and perfusionist according to the patient’s condition. Transfusion of RBCs when postoperative hemoglobin level is below 80 g/L. Transfusion of fresh frozen plasma, platelets, and cold precipitation when bleeding is excessive.
Zhou Y., Chen T., Yang C., Liu J., Yang X., Zhang B, & Jin Z. (2023). Risk factors associated with positive bacterial culture in salvaged red blood cells during cardiac surgery and postoperative infection incidence: A prospective cohort study. Frontiers in Medicine, 10, 1099351.
Publication 2023
Anesthesia Anesthetist BLOOD Blood Platelets Blood Transfusion Cells Cold Temperature Erythrocytes Hemoglobin Heparin Mediastinum Medical Devices Midazolam Patients Pipecuronium Plasma, Fresh Frozen Pressure Propofol Protamines Rocuronium Saline Solution Sufentanil Surgeons Wounds
5
Anesthetic Induction and Epidural Analgesia

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Publication 2023
Anesthesia Bupivacaine Catheters Dipyrone Epidural Anesthesia Intravenous Infusion Management, Pain Needles Normal Saline One-Lung Ventilation Operative Surgical Procedures Patients Pirinitramide Propofol Rocuronium Spaces, Epidural Sufentanil

Top products related to «Rocuronium»

1
Propofol by Fresenius
Sourced in Germany, Austria, China, United States, United Kingdom, Belgium, Sweden, Israel
Propofol is a pharmaceutical product used as a general anesthetic and sedative. It is a sterile, nonpyrogenic injectable emulsion that contains the active ingredient propofol and other inactive ingredients. Propofol is administered intravenously and is used to induce and maintain general anesthesia, as well as for sedation in intensive care unit (ICU) settings.
2
Rocuronium by Merck Group
Sourced in Germany
Rocuronium is a non-depolarizing neuromuscular blocking agent used in anesthesia. It acts by competitively binding to acetylcholine receptors at the neuromuscular junction, preventing muscle contraction. Rocuronium is administered intravenously and is used to facilitate tracheal intubation and provide skeletal muscle relaxation during surgery or mechanical ventilation.
3
Ultiva by GlaxoSmithKline
Sourced in United Kingdom, Sweden, Belgium
Ultiva is a sterile, white to off-white, lyophilized powder for intravenous administration. Its active ingredient is remifentanil hydrochloride, a rapid-acting, potent opioid analgesic. Ultiva is indicated for the induction and maintenance of anesthesia and for the reduction of postoperative pain.
4
Propofol lipuro by B. Braun
Sourced in Germany, France
Propofol-Lipuro is an intravenous anesthetic agent manufactured by B. Braun. It is used to induce and maintain general anesthesia. The product contains the active ingredient propofol emulsified in a lipid solution.
5
Tof watch sx by Organon
Sourced in Ireland
The TOF-Watch SX is a time-of-flight mass spectrometer designed for analytical applications. It provides precise mass measurement and high-resolution data for a wide range of samples. The device operates based on the time-of-flight principle to determine the mass-to-charge ratio of ionized analytes.
6
Orchestra base primea by Fresenius
Sourced in France, Germany
The Orchestra Base Primea is a laboratory equipment product offered by Fresenius. It is designed to perform essential functions within a laboratory setting. The core function of this product is to provide a reliable and versatile platform for various laboratory tasks, but a detailed description cannot be provided while maintaining an unbiased and purely factual approach.
7
Rocuronium by Fresenius
Sourced in Sweden
Rocuronium is a non-depolarizing neuromuscular blocking agent used in anesthesia and critical care settings. It acts by competitively inhibiting the action of acetylcholine at the neuromuscular junction, resulting in muscle relaxation. This allows for improved intubation conditions and facilitation of mechanical ventilation.
8
Telazol by Zoetis
Sourced in United States
Telazol is a sterile, injectable anesthetic agent composed of equal parts of the active ingredients tiletamine hydrochloride and zolazepam hydrochloride. It is intended for use in veterinary medicine as a general anesthetic and for the chemical restraint of animals.
9
Sedline by Masimo
Sourced in United States
SedLine is a patient brain function monitoring system that provides key data about a patient's brain activity during surgical procedures. It uses advanced signal processing to continuously measure and display brain activity throughout the perioperative period.
10
Desflurane by Baxter
Sourced in United States, Germany
Desflurane is a halogenated anesthetic agent used for the induction and maintenance of general anesthesia. It is a colorless, non-flammable, and volatile liquid.

More about "Rocuronium"

Rocuronium is a non-depolarizing neuromuscular blocking agent (NMBA) commonly used in anesthesia and critical care settings.
It works by competitively antagonizing the neurotransmitter acetylcholine at the neuromuscular junction, resulting in a reversible paralysis of skeletal muscles.
This makes it a valuable tool for facilitating intubation and providing muscle relaxation during surgical procedures.
Rocuronium is known for its rapid onset of action and intermediate duration of effect, making it a popular choice among anesthesiologists and critical care providers.
It is often used in conjunction with other anesthetic agents like Propofol, Ultiva, and Desflurane to achieve optimal sedation and muscle relaxation during surgical procedures.
In addition to its use in anesthesia, Rocuronium may also be utilized in critical care settings, such as for patients requiring mechanical ventilation or those undergoing various medical interventions.
The ability to precisely control muscle relaxation can be crucial in these scenarios.
Researchers and clinicians can leverage platforms like PubCompare.ai to optimize their Rocuronium protocols by comparing the most efficient procedures from published literature, preprints, and patents.
This can help identify the best practices and streamline the use of Rocuronium, potentially improving patient outcomes and reducing the risk of complications.
Furthermore, related technologies like the TOF-Watch SX and Orchestra Base Primea can be used to monitor the neuromuscular blockade and titrate the dosage of Rocuronium accordingly, ensuring optimal muscle relaxation and patient safety.
By understanding the versatility and clinical applications of Rocuronium, as well as the tools available for its optimization, healthcare professionals can better utilize this essential neuromuscular blocking agent to provide high-quality care and improve patient outcomes.