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Ropivacaine

Ropivacaine is a long-acting local anesthetic agent derived from the amino amide group.
It is used for regional anesthesia and pain relief, including epidural and peripheral nerve block procedures.
Ropivacaine has a high potency and a lower risk of cardiotoxicity compared to other local anesthetics.
Researches involving Ropivacaine benefit from enhanced reproducibility and accuracy, which can be facilitated by the PubCompare.ai tool.
This AI-powered platform helps researchers easily locate relevant protocols from literature, preprints, and patents, and leverages data comparisons to identify the best Ropivacaine protocols and products for their studies.

Most cited protocols related to «Ropivacaine»

This prospective cohort study was a secondary analysis of data collected from a clinical trial investigating the efficacy of different epidural delivery–maintenance regimens. The study was conducted between January 2015 and March 2019 in KK Women’s and Children’s Hospital, Singapore on parturients who received epidural analgesia for labor. The study protocol was developed according to the Strengthening the Reporting of Observational studies in Epidemiology (STROBE) guidelines on reporting cohort studies. The study was reviewed and approved by the SingHealth Centralized Institutional Review Board, Singapore (SingHealth CIRB ref 2014/670/D or 2018/3128), and registered on ClinicalTrials.gov (NCT02278601) on October 26, 2014.
The study included nulliparous parturients aged 21–50 years, 36 gestational weeks or more, with a singleton fetus, American Society of Anesthesiologists’ physical status I and II, and in early labor (cervical dilation <5 cm) who had requested epidural labor analgesia. Parturients with multiple pregnancies, noncephalic fetal presentation, obstetric complications (eg, preeclampsia, premature rupture of membranes), contraindications to neuraxial blockade, had received parenteral opioids within 2 hours prior to initiation of epidural analgesia, or had suspected inadvertent dural puncture during initiation of epidural analgesia were excluded.
All epidurals utilized the B Braun Espocan set with a combined spinal–epidural technique using a conventional single interspace needle-through-needle approach. The spinal component was ropivacaine 2mg and fentanyl 15mcg and the epidural infusion solution 0.1% ropivacaine with 2µg/mL of fentanyl. Almost all cases (>99%) were done in the sitting position and utilized a midline approach. The clinical trial involved patients who were placed on patient-controlled epidural analgesia regimens with patient bolus of 5mL per bolus. Once the patient had received epidural labor analgesia and was comfortable, predelivery questionnaires were administered: the PCS, a validated self-reported questionnaire to evaluate the negative thought processes that one may have upon exposure to actual or anticipated pain or painful experiences; the EPDS, a ten-item self-reported questionnaire used as a screening tool for antenatal and PND, scored from 0 to 30, with ≥10 used to indicate clinically significant depressive symptoms15 (link),16 (link) (in our study, this was defined as probable PND and would thus encompass the range of PND states);17 (link) Cohen’s Perceived Stress Scale (PSS), a ten-item validated psychometric instrument to quantify the perception of stress; and Spielberger’s State–Trait–Anxiety Inventory (STAI), a 40-item self-report tool that assesses transient anxiety (state) at the moment of scoring, the dispositional anxiety (trait), and anxiety in general. Parturients’ demographic, obstetric, and epidural analgesia data from medical records were also collected in this study. After patients had delivered, they were interviewed by the anesthetic team for assessment of overall satisfaction with epidural analgesia, as per routine clinical practice. A 20-minute phone survey was conducted at 5–9 weeks postdelivery to obtain postdelivery EPDS and STAI scores.
Publication 2020
Analgesia, Epidural Anesthesiologist Anesthetics Anxiety Central Nervous System Dilatations, Cervical Ethics Committees, Research Fentanyl Fetal Membranes, Premature Rupture Fetus Mental Processes Needles Neuroses, Anxiety Obstetric Delivery Obstetric Labor Opioids Pain Parenteral Nutrition Patient-Controlled Analgesia Patients Physical Examination Pre-Eclampsia Pregnancy Psychometrics Punctures Ropivacaine Satisfaction Transients Treatment Protocols Woman
All statistical analyses were conducted with SPSS software, version 18.0 (SPSS Inc., Chicago, USA). PP plot (probability-probability plot) indicates the normal distribution of data. Values are presented as mean ± standard deviation (SD) or number (percentage) at appropriate. Quantitative variables (VAS scores, labor time, apgar scores and doses of ropivacaine and sufentanil) were compared by Student’s t test and χ2 test was used for categorical variables (adverse pregnancy outcomes and adverse drug reactions). Repeated-measures ANOVA were used for the comparison of different time points within the group. All reported P values are two-sided, and P value of less than 0.05 was considered statistically significant.
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Publication 2020
Apgar Score Drug Reaction, Adverse neuro-oncological ventral antigen 2, human Obstetric Labor Ropivacaine Student Sufentanil
Anesthetic techniques were performed as described previously [18 (link)]. Patients received thoracic epidural anesthesia, or LMA Classic (Tele flex, Sweetmeat, Ireland) insertion combined with intrathoracic vagal blockade and intercostal nerve blockade. An epidural catheter was inserted at the T6/T7 or T8/T9 thoracic interspace. We administered 2% lidocaine 2 mL as a testing dose and 0.375–0.5% ropivacaine was used to attain a sensory block between the T2 and T12 dermatomes. Mask- and nasopharyngeal airway-assisted ventilation was provided with an oxygen flow of 3–5 L/min. Sedation was initiated by intravenous infusion of remifentanil and propofol. LMA was inserted after anesthetic induction, allowing spontaneous ventilation.
At the end of procedure, the collapsed lung was re-expanded with positive pressure through mask ventilation or negative-pressure suction through the chest tube. Intravenous drugs were stopped immediately and the epidural catheter was removed. Patients were transferred to the PACU, then to the ward or ICU according to the evaluation of their preoperative cardio-pulmonary function and intraoperative conditions.
Publication 2018
Anesthetics Atelectasis Catheters Chest Tubes Epidural Anesthesia Intravenous Infusion Lidocaine Lung Nasopharynx Nerve Block Oxygen Patients Pharmaceutical Preparations Pneumogastric Nerve Pressure Propofol Remifentanil Ropivacaine Sedatives Suction Drainage
Preparation of aortic rings for tension measurement was performed as previously described [14 (link)]. Male Sprague-Dawley rats weighing 250-300 g were anesthetized by intramuscular injection of zoletil (15 mg/kg, Virbac Laboratories, Carros, France). The descending thoracic aorta was dissected free, and surrounding connective tissues and fat were removed under microscopic guidance in a Krebs solution bath of the following composition: 118 mM NaCl, 4.7 mM KCl, 1.2 mM MgSO4, 1.2 mM KH2PO4, 2.4 mM CaCl2, 25 mM NaHCO3, and 11 mM glucose. The aorta was then cut into 2.5-mm rings, suspended on Grass isometric transducers (FT-03, Grass Instrument, Quincy, MA, USA) under a 3.0-g resting tension in a 10-ml Krebs bath at 37℃, and aerated continuously with 95% O2 and 5% CO2 to maintain pH values within the range of 7.35-7.45. The rings were equilibrated at a 3.0-g resting tension for 120 min, and the bath solution was changed every 30 min. The endothelium was removed from the aortic rings by inserting a 25-gauge needle tip into the lumen of the rings and gently rubbing the ring for a few seconds. After contractions induced by 10-8 M phenylephrine stabilized, endothelial denudation of aortic ring was confirmed by observation of less than 15% relaxation in response to acetylcholine (10-5 M). The contractile response induced by an isotonic 60 mM KCl solution was measured for all aortic rings to check vascular smooth muscle viability and was used as a reference value (100%). The isotonic 60 mM KCl solution was prepared by replacing the NaCl in Krebs solution with an equimolar amount of KCl. After washing out KCl from the organ bath and allowing the return of isometric tension to baseline, the main experiments were performed according to experimental protocols described below. Each ring was used for only one concentration-response curve induced by bupivacaine alone or a local anesthetic (bupivacaine, ropivacaine, lidocaine and mepivacaine) plus lipid emulsion. Because this in vitro study used endothelium-denuded aorta, the Krebs solution contained the nitric oxide synthase inhibitor NW-nitro-L-arginine methyl ester (L-NAME, 10-4 M) to prevent the release of endogenous nitric oxide from residual endothelium [14 (link)].
Publication 2013
Acetylcholine Aorta arginine methyl ester Bath Bicarbonate, Sodium Bupivacaine Connective Tissue Emulsions Endothelium Glucose Intramuscular Injection Isotonic Solutions Krebs-Ringer solution Lidocaine Lipids Local Anesthesia Males Mepivacaine Microscopy Muscle, Smooth, Vascular Muscle Contraction Needles Neoplasm Metastasis NG-Nitroarginine Methyl Ester Nitric Oxide Synthase Oxide, Nitric Phenylephrine Poaceae Rats, Sprague-Dawley Ropivacaine Sodium Chloride Sulfate, Magnesium Thoracic Aorta Transducers Zoletil
Invasive radial arterial blood pressure, heart rate (HR), electrocardiogram (ECG), percutaneous oxygen saturation (SpO2), and bispectral index (BIS) were routinely monitored after the patients entered to the operating room. Peripheral intravenous access and right central vein access were established. Prior to anesthesia induction, patients in both groups received ultrasound-guided bilateral QLB in the lateral position. Following disinfection of the intervention area, a convex probe (2–5 HZ, Edge, Sonosite, Seattle, USA) was positioned on the anterosuperior iliac crest and moved cranially until the external oblique, internal oblique, and transversus abdominis were identified. Then, the probe was moved posteriorly, and the quadratus lumborum muscle was observed. A 22 gauge × 80 mm needle (Kindly, Shanghai, China) was inserted into the posterior part of the QL muscle. After confirming the optimal site by hydrodissection, group Q was injected with 20 mL of 0.3 % ropivacaine (Naropin, AstraZeneca AB Company, Södertälje, Sweden), and group C was injected with 20 mL of 0.9 % saline on each side. Posterior spread was observed (Fig. 2). After the block, the dermatomes of the sensory block at the 15th minutes were evaluated using pinprick for all subjects.

Ultrasonographic image of QLB. Arrow shows the direction of needle. EO, external oblique muscle; IO, internal oblique muscle; TA, transversus abdominis; QL, quadratus lumborum; PM, psoas major; ES, erector spinae

After QLB, 0.02–0.03 mg/kg midazolam, 0.3–0.4 µg/kg sufentanil, 1.5–2 mg/kg propofol, and 0.6–0.8 mg/kg rocuronium were administered intravenously for anesthesia induction. Mechanical ventilation was performed by volume-controlled ventilation after intubation to maintain the end-tidal carbon dioxide pressure (PetCO2) at 30–40 mmHg. Anesthesia was maintained with propofol 0.1–0.2 mg/kg/min and remifentanil 0.2–0.3 µg/kg/min to maintain a BIS of 40–60. Fluid and vasoactive drugs were administered to maintained intraoperative haemodynamics within the appropriate range during surgery by experienced anesthesiologists. Following surgery, 0.15 µg/kg sufentanil and parecoxib 40 mg IV were used for postoperative analgesia. A patient-controlled intravenous analgesia pump with sufentanil was administered to all patients after being transferred to the recovery room.
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Publication 2021
Anesthesia Anesthesiologist Carbon dioxide Disinfection Electrocardiography External Abdominal Oblique Muscle Hemodynamics Iliac Crest Internal Abdominal Oblique Muscle Intubation Management, Pain Mechanical Ventilation Midazolam Muscle, Back Muscle Tissue Naropin Needles Normal Saline Operative Surgical Procedures Oxygen Saturation parecoxib Patient-Controlled Analgesia Patient Monitoring Patients Pharmaceutical Preparations Pressure Propofol Rate, Heart Remifentanil Rocuronium Ropivacaine Saturation of Peripheral Oxygen Sufentanil Transversus Abdominis Ultrasonography Veins

Most recents protocols related to «Ropivacaine»

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Publication 2023
Acetaminophen Anesthesia Anesthesia, Conduction Anesthesiologist Antibiotics, Antitubercular Aprepitant Aspirin Bupivacaine Cefazolin Cephalexin Chemoprevention Chlorhexidine chlorhexidine gluconate Clindamycin Deep Vein Thrombosis Dexamethasone Ethanol Famotidine Fentanyl Gabapentin Hypersensitivity Ibuprofen Isopropyl Alcohol Management, Pain Medical Devices Meloxicam Nerve Block Ondansetron Operative Surgical Procedures Oxycodone Pain, Postoperative Patients Penicillins Percocet Postoperative Nausea Powder Ropivacaine Scopolamine Skin Surgery, Day Therapeutics Thigh Treatment Protocols Ultrasonics Vancomycin Wounds
The anesthetic method was determined mainly according to the patients' preferences. Whereas, patients who were incapable of enduring awake DBS, including those with extreme anxiety, reduced cooperation, severe convulsions and difficult breathing, were operated under GA. We also showed reasons for the patients who were operated under GA in Supplementary Table 1. According to the anesthetic method applied, patients were assigned to LA group and GA group. In LA group, patients received local scalp anesthesia with 0.5% ropivacaine and kept conscious without sedation during MER and electrode implantation. In GA group, patients were administered a bolus of 2 mg/kg BW propofol and 1 mg/kg BW remifentanil for induction. Then, anesthesia was maintained at 2 mg/kg BW propofol and 1 mg/kg BW remifentanil by a target-controlled infusion (TCI) system. Bispectral index (BIS) was applied to monitor the depth of anesthesia. The infusion of anesthetics was adjusted before MER and BIS was maintained at 40–60 to ensure the recognition of STN signals.
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Publication 2023
Anesthesia Anesthetics Anxiety Conscious Sedation Local Anesthesia Ovum Implantation Patients Propofol Remifentanil Ropivacaine Scalp Seizures
The primary goal of this dose-finding study was to estimate the MEC95 for US-guided CEB. Through a small-sample up-and-down sequential study design of binary allocation response variables as described by Saranteas et al. [18 (link)], we determined the concentration of local anesthetic (20 ml and25ml of ropivacaine) to be administered through the efficiency of block. The first patients in both groups received a concentration of 0.5% (20 ml in group 1 and 25 ml in group 2) of ropivacaine. The next case concentration of ropivacaine was determined by the effectiveness of CEB from previous case. According to Dixon’s up-and-down sequential method, ineffective block resulted in a 0.025% increase in the ropivacaine concentration of the next patient, while effective block resulted in a 0.025% decrease ropivacaine concentration.
Dixon and Massey determined the sample size by using the formula, n = 2(SD/SEM)2[19 ]. With a 0.05 SD and 0.012 SEM, 34 patients must be included in this study. Considering an attrition rate of 10%, we included 37 patients in each group. The MEC95 was estimated using probit regression. The data were processed using IBM SPSS Statistics version 23.0 (IBM Corporation, Armonk, New York). Mean (SD) values were analyzed by using the unpaired Student t test or Welch t test for different variances, median (interquartile) by using the Mann–Whitney U test. Categorical variables were reported as Number (proportion) and evaluated using Fisher’s exact or the X2 test where appropriate. For all tests, P < 0.05 was defined as statistically significant.
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Publication 2023
Local Anesthesia Patients Ropivacaine Student Tooth Attrition
Patients in the PVB and RIB groups were intervened by ultrasound-guided nerve block in the lateral position with local anesthesia. The PVB was performed using the in-plane technique with a linear 4–10 MHz ultrasound probe (LOGIQe, GE Healthcare, Waukesha, WI., U.S.A.). At the parasagittal view, subcutaneous tissues, T5 transverse processes, superior costotransverse ligament (SCTL), and pleura were visualized. An 18 G block needle was inserted vertically or slightly caudally into the paravertebral space (PVS) under the guidance of ultrasound. After the penetration of the SCTL, a slight aspiration was performed to ensure the avoidance of vessels or pleura. Then, 1–2 ml of normal saline was injected into the PVS, the pressure of which pushed down the pleura. The position of the needle tip was confirmed, and 0.4% ropivacaine (Zhejiang Xianju Pharmaceutical Co., Ltd., Zhejiang, China) at 3 mg/kg was injected into the PVS.
A linear 4–10 MHz ultrasound probe (LOGIQe, GE Healthcare, Waukesha, WI, U.S.A.) was placed on the medial border of the scapula between the 4th and 5th rib of the patients in the RIB group. In the ultrasound image, the trapezius muscle, rhomboid muscle, intercostal muscles, pleura, and lung were identified. Under the aseptic condition, an 18 G block needle was inserted laterally in the plane of the T5 level guided by an ultrasound probe with an in-plane technique. The vessel injection should be confirmed negative through aspiration, and 1–3 ml of normal saline was injected to divide the rhomboid and intercostal muscle, and 0.4% ropivacaine at 3 mg/kg was injected into the deep layer of the rhomboid muscle.
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Publication 2023
Asepsis Bladder Detrusor Muscle Blood Vessel Intercostal Muscle Ligaments Local Anesthesia Lung Muscle Tissue Needles Nerve Block Normal Saline Patients Pharmaceutical Preparations Pleura Pressure Ropivacaine Scapula Subcutaneous Tissue Transverse Processes Trapezius Muscle Ultrasonics Ultrasonography
This study was approved by the Ethics Committee of Nanjing Drum Tower Hospital (No. 2018-160-02) and registered in the Chinese Clinical Trial Registry (ChiCTR2100054057, https://www.chictr.org.cn, June 5, 2022; Yan Wang, M D.). Clinical trial procedures followed the principles of the Declaration of Helsinki.
A total of 132 patients with lung nodules receiving VATS with general anesthesia (the GA Group), ultrasound-guided RIB (RIB Group), or PVB (the PVB Group) in the plane of the T5 level using 0.4% ropivacaine (Zhejiang Xianju Pharmaceutical Co., Ltd., Zhejiang, China) at 3 mg/kg between June 8th, 2022, and August 10th, 2022, were recruited.
Inclusion criteria are as follows: (1) 18–80 years of age; (2) American Society of Anesthesiologists (ASA) Class I-III; and (3) written informed consent was obtained.
Exclusion criteria are as follows: (1) Allergy to local anesthetics, nonsteroidal anti-inflammatory drugs, and opioids; (2) infection of the skin at the puncture site; (3) peptic ulcer disease or inflammatory bowel disease; (4) renal deficiency; (5) transferring to thoracotomy; (6) daily use of opioids; and (7) bilateral operation.
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Publication 2023
Anesthesiologist Anti-Inflammatory Agents, Non-Steroidal Chinese Ethics Committees, Clinical General Anesthesia Hypersensitivity Inflammatory Bowel Diseases Kidney Local Anesthetics Opioids Patients Peptic Ulcer Pharmaceutical Preparations Punctures Ropivacaine Skin Diseases, Infectious Thoracic Surgery, Video-Assisted Thoracotomy Ultrasonics

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Ropivacaine is a local anesthetic used to numb specific areas of the body. It is a long-acting, amide-type anesthetic agent that can be used for various medical procedures, including regional anesthesia, epidural anesthesia, and peripheral nerve blocks.
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Ropivacaine is a local anesthetic used in the medical field. It is a member of the amide class of local anesthetics and is typically used for various medical procedures requiring anesthesia or pain relief.
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Naropin is a local anesthetic medication used to temporarily prevent or relieve pain. It is a clear, colorless solution for injection or infusion. The active ingredient in Naropin is ropivacaine hydrochloride.
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Lidocaine is a local anesthetic and antiarrhythmic drug used in the medical field. It is a synthetic compound that works by blocking sodium channels in the body, effectively numbing or anesthetizing the affected area. Lidocaine is commonly used to reduce pain and discomfort during various medical procedures.
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Bupivacaine is a local anesthetic used in medical procedures. It is a long-acting amide-type local anesthetic that blocks the generation and conduction of nerve impulses. Bupivacaine is available in various formulations for different applications.
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The SonoSite M-Turbo is a compact and portable ultrasound system designed for a variety of medical applications. It features a high-resolution display, intuitive user interface, and advanced imaging capabilities to support clinical decision-making. The SonoSite M-Turbo is a versatile tool that can be used in various healthcare settings.
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More about "Ropivacaine"

Ropivacaine, a long-acting local anesthetic agent, is a popular choice for regional anesthesia and pain relief procedures, including epidural and peripheral nerve block techniques.
Derived from the amino amide group, Ropivacaine offers a high potency and a lower risk of cardiotoxicity compared to other local anesthetics like Lidocaine and Bupivacaine.
Researchers studying Ropivacaine can benefit from enhanced reproducibility and accuracy, facilitated by the PubCompare.ai tool.
This AI-powered platform helps scientists easily locate relevant protocols from literature, preprints, and patents, and leverages data comparisons to identify the best Ropivacaine protocols and products for their studies.
Naropin, a brand name for Ropivacaine, is commonly used in anesthesia and pain management.
The SonoSite M-Turbo and Triathlon ultrasound systems are often employed to guide the administration of Ropivacaine during regional anesthesia procedures.
When conducting research involving Ropivacaine, it's important to consider factors such as dosage, administration methods, and potential interactions with other medications like Penicillin.
The PubCompare.ai tool can assist researchers in navigating these complexities and optimizing their Ropivacaine-based studies for maximum reproducibility and accuracy.