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Rose Bengal

Rose Bengal is a synthetic dye used in various medical and scientific applications.
It is a red, water-soluble compound commonly used as a photodynamic therapy agent, a diagnostic tool in ophthalmology, and a stain for biological samples.
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Most cited protocols related to «Rose Bengal»

1
Consensus on Sjögren's Syndrome Criteria
Cited 19 times
In February 2004, the panel of experts gathered for a face-to-face meeting moderated by a statistician (SCS) and an epidemiologist (CHS). The goal of this meeting was to obtain consensus (at least 80%) on the target population to whom the classification criteria would apply, and the initial list of variables or criteria items that would be collected as part of SICCA. The meeting began with presentation of a comprehensive literature review by one of the senior investigators (TED) of the 11 previous classification and diagnostic criteria for SS that had been published in the past 40 years, none of which had been endorsed by the ACR or EULAR.
There was consensus among the panel that the criteria should apply to the population of patients who may be referred to a specialist because of signs and/or symptoms possibly suggesting SS. Recruitment strategies and eligibility criteria are described below. The rationale for selecting this target population is that a given patient would not be evaluated for SS unless she/he had signs or symptoms suggesting this diagnosis. There was also consensus that if asked to select cases and controls for validation of new classification criteria, panel members would use objective tests (e.g., specific serum measures of autoimmunity, ocular staining reflecting lacrimal hypofunction, and LSG biopsy reflecting FLS) that would likely be part of the new classification criteria, leading to circularity. Therefore, it was agreed that no diagnostic labels would be used for enrollment, and that all participants would undergo the same set of standardized objective tests, and questionnaires capturing various signs and symptoms.
The panel agreed upon examinations and tests used to assess ocular and oral signs and symptoms, tear and salivary function, LSG biopsy results and various serum measures of autoimmunity. The list created was based both on published results and on the clinical experience of panel members. There was discussion among the rheumatologists regarding which extra-glandular manifestations possibly associated with SS should be captured, and a consensus was achieved regarding a list of signs/symptoms that would be measured through a targeted rheumatologic examination, review of systems, careful medical history and serologic laboratory measures. Similarly, the oral medicine specialists agreed on a list of tests measuring salivary function (both stimulated parotid and UWS flow rates), and salivary gland expression of autoimmunity through biopsy of LSG, examining them for the presence of FLS, and measuring FS accordingly as described in detail elsewhere (15 (link)). The ophthalmologists agreed on tests evaluating participants for the presence of keratoconjunctivitis sicca (KCS). There was consensus that, while rose Bengal had been widely used for grading conjunctival and corneal damage in patients with KCS, it is inherently toxic to epithelial cells and very painful for patients. Therefore, fluorescein was selected to grade the cornea and lissamine green the bulbar conjunctiva. Effectiveness for grading KCS is established for both (16 (link)). They agreed on a standardized quantitative grading system that would be easily reproducible and could be used in clinical practice in the future (17 (link)). Ocular staining score (OSS) is the sum of a 0–6 score for fluorescein staining of the cornea and a 0–3 score for lissamine green staining of both nasal and temporal bulbar conjunctivae, yielding a total score ranging from 0 to 12. Alternative established tests for dryness used in prior criteria, such as tear break-up time (TBUT) and unanesthetized Schirmer test, were also included.
The final list of criteria items that was agreed upon by the end of the first meeting included nearly all those previously reported in the relevant literature. It has been described previously (12 (link)) and is available at http://sicca.ucsf.edu.
Shiboski S., Shiboski C., Criswell L., Baer A., Challacombe S., Lanfranchi H., Schiødt M., Umehara H., Vivino F., Zhao Y., Dong Y., Greenspan D., Heidenreich A., Helin P., Kirkham B., Kitagawa K., Larkin G., Li M., Lietman T., Lindegaard J., McNamara N., Sack K., Shirlaw P., Sugai S., Vollenweider C., Whitcher J., Wu A., Zhang S., Zhang W., Greenspan J, & Daniels T. (2012). American College of Rheumatology Classification Criteria for Sjögren’s Syndrome: A Data-Driven, Expert Consensus Approach in the SICCA Cohort. Arthritis care & research, 64(4), 475-487.
Publication 2012
Autoimmunity Biopsy Conjunctiva Conjunctiva, Bulbar Cornea Cornea Injuries Diagnosis Eligibility Determination Epidemiologists Epithelial Cells Eye Face Fast Green FCF Fluorescein Keratoconjunctivitis Sicca Nose Ophthalmologists Pain Parotid Gland Patients Physical Examination Rheumatologist Rose Bengal Salivary Glands Serum Signs and Symptoms Specialists Target Population Tears
2
Localized Vessel Occlusion via Photosensitization
Cited 11 times
A continuous wave green-light laser (λ = 532 nm) (TIM-622; Transverse Industries, Taipei Hsien, Taiwan) was directed onto the beam axis of the microscope with a dichroic mirror (see Figure S1). The green-light beam underfilled the back aperture of the objective and was aligned so it focused at the center of the same plane as the near-infrared pulsed laser beam and formed an approximately 5-μm diameter spot. As the green-light overlapped with the fluorescent spectrum of fluorescein, the green-light was delivered in pulses of 1-s duration that were interspersed with TPLSM imaging.
Vessels targeted for clotting were centered in the imaging field (see Figure 2A). The rat was then given a 0.3-ml intravenous injection of 1% (w/v) rose bengal (Na salt) in PBS, and the wall of the target vessel was irradiated with 0.1 to 5 mW of green laser light for a total of 30 to 600 s. Irradiation of a photosensitizer leads to the production of singlet oxygen [63 (link)], which damages the wall of the vessel and subsequently triggers a clotting cascade that leads to an occlusion [16 (link),17 (link)]. We slowly increased the green laser power while monitoring clot formation in near real time and used the minimum power required to trigger clot formation in the target vessel. This procedure led to the formation of a single, localized clot (see Figure 2C and Video S1). In control experiments, green laser irradiation at a typical power led to no visible effects on the target vessel in the absence of rose bengal (Figure S7) and no observable retention of fluorescein-dextran in the tissue below the target vessel (see Figure S5).
Schaffer C.B., Friedman B., Nishimura N., Schroeder L.F., Tsai P.S., Ebner F.F., Lyden P.D, & Kleinfeld D. (2006). Two-Photon Imaging of Cortical Surface Microvessels Reveals a Robust Redistribution in Blood Flow after Vascular Occlusion. PLoS Biology, 4(2), e22.
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Publication 2006
Blood Vessel Clotrimazole Continuous Wave Lasers Dental Occlusion Epistropheus Fluorescein fluorescein-dextran Light Methyl Green Microscopy Photosensitizing Agents Precipitating Factors Pulses Radiotherapy Retention (Psychology) Rose Bengal Singlet Oxygen Sodium Chloride Tissues
3
Fluorescence Lifetime Imaging Ophthalmoscope (FLIO)
Cited 7 times
FLIO instrumentation has been described in detail elsewhere [17 , 18 (link)]. Thus, only a short description is given here. A schematic of the FLIO instrumentation is shown in Fig 1A.
The basis is a confocal scanning laser ophthalmoscope (cSLO, HRA-2, Heidelberg Engineering GmbH, Heidelberg, Germany). Fundus images (30°, 256x256 pixels) are recorded in high-speed mode at 8.8 frames/s. A pulsed diode laser with a wavelength of 473 nm (BDL-473-SMC, Becker & Hickl GmbH), a pulse width of approximately 70 ps (full width at half maximum) and a repetition rate of 80 MHz is fiber-coupled (single-mode) into the cSLO to excite the autofluorescence. The laser power in the corneal plane is circa 150 μW, well below the exposure limits set by the ANSI standards for durations of up to 8 h [19 ]. A multimode fiber collects the fluorescence photons and transmits them to filters to block the excitation light. A dichroic mirror (edge-wavelength 560 nm) splits the fluorescence photons into two spectral channels (498–560 nm and 560–720 nm), and there is one detector for each channel (HPM-100-40, Becker & Hickl GmbH). Each detector is connected to a time-correlated single photon-counting (TCSPC) device (SPC-150, Becker & Hickl GmbH). The TCSPC technique [9 , 20 , 21 ] generates time-, space- and spectrum-resolved fluorescence decay datasets.
The instrument response function (IRF) was measured using a 25 μM Eosin Y solution which additionally contained 5 M potassium iodide. The Eosin Y solution was prepared by dissolving Eosin Y powder (Sigma-Aldrich Chemie GmbH, Taufkirchen, Germany) in a small volume of dimethyl sulfoxide (DMSO) first. Then water was added to obtain a stock solution of 2 mM which finally was further diluted down to 25 μM using a solution of 5 M potassium iodide. The Eosin Y fluorescence can be excited from 350 to 500 nm and ranges between 450 and 680 nm with a sufficient intensity. Based on the reported Rose Bengal fluorescence lifetime of ca. 16 ps when dissolved in 5 M potassium iodide [22 (link)] it is reasonable to assume that Eosin Y, another Fluorescein derivative, shows similar characteristics which could be confirm by in-house measurements. Additionally, no differences in terms of shape and width were found in the IRFs based on the Eosin Y fluorescence in comparison to the IRFs measured using scattered excitation laser light. To measure the Eosin Y fluorescence based IRF, a flat cylindrical quartz cuvette with a detachable window and a volume of 90 μL (124–0.5–40, Hellma GmbH & Co. KG, Müllheim, Germany) was placed slightly tilted in front of the FLIO device. The acquisition time was set to 2–3 minutes which is comparable to typical measurements in volunteers. The IRF images showed no sign of spatial variation. The full width at half maximum of the IRF is 172 ps for channel 1 (498–560 nm) and 153 ps for channel 2 (560–720 nm). The IRFs of both spectral channels are shown in Fig 1B. All IRFs used in this work have similar properties as those in Fig 1B, including experiment 5.
Klemm M., Schweitzer D., Peters S., Sauer L., Hammer M, & Haueisen J. (2015). FLIMX: A Software Package to Determine and Analyze the Fluorescence Lifetime in Time-Resolved Fluorescence Data from the Human Eye. PLoS ONE, 10(7), e0131640.
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Publication 2015
Cardiac Arrest Cornea Eosin Fibrosis Fluorescein Fluorescence Light Medical Devices Ophthalmoscopes Potassium Iodide Powder Pulse Rate Quartz Reading Frames Rose Bengal Sulfoxide, Dimethyl Voluntary Workers
4
Corneal Fluorescein and Rose Bengal Staining
Cited 6 times
One microliter of 0.1% liquid sodium fluorescein was dropped into the conjunctival sac. After 3 blinks, BUTs were recorded in seconds. Ninety seconds later, corneal epithelial damage was graded with a cobalt blue filter under a slit-lamp microscope (Kanghua Science & Technology Co., Ltd, Chongqing, China). The cornea was divided into 4 quadrants, which were scored, respectively. The 4 scores were added to arrive at a final grade (total, 16 points). The fluorescein score was analyzed as previously described [10 (link)] with essential modification, briefly, as follows; absent, 0; slightly punctate staining less than 30 spots, 1; punctate staining more than 30 spots, but not diffuse, 2; severe diffuse staining but no positive plaque, 3; positve fluorescein plaque, 4.
One microliter of 1% rose bengal was instilled into the conjunctival sac. Fifteen seconds later, the scores were graded under slit-lamp microscope using the Van Bijsterveld system [11 (link)]. Representative images of each scale in the grading system were provided (Figure 1E-L).
Lin Z., Liu X., Zhou T., Wang Y., Bai L., He H, & Liu Z. (2011). A mouse dry eye model induced by topical administration of benzalkonium chloride. Molecular Vision, 17, 257-264.
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Publication 2011
Blinking Cobalt Cornea Cornea Injuries Exanthema Fluorescein Neoplasm Metastasis Rose Bengal Sac, Conjunctival Senile Plaques Slit Lamp Examination Sodium Fluorescein
5
Oxidative Mapping of Oligonucleotides
Cited 5 times
All oxidations were conducted in 20 mM MPi (pH 7.4) 120 mM MCl (M = Na or K) at 37 °C at a 10 µM ODN concentration. Oxidation sites were determined on reactions doped with 20,000 cpm of 5’-32P labeled strand in a 50-µL reaction utilizing the following oxidant conditions: (1) Riboflavin (Type I photooxidant) was added to give a 50 µM final concentration and solutions were exposed to 350-nm light for 5–20 min, (2) CO3•− was produced when SIN-1 generated ONOO− (<3 mM) was allowed to react with 25 mM MHCO3 (M = Na or K) present, and the reaction progressed through the thermal decomposition of SIN-1 for 0.5–3 h, (3) Rose Bengal (Type II photooxidant) was added to a final concentration of 50 µM and solutions were exposed to 350-nm light for 5–20 min, and (4) Cu-mediated oxidations were conducted with 10 µM Cu(OAc)2 that was preincubated with the ODNs for 30 min prior to the addition of 10–1000 µM H2O2, and allowed to react for 30 min prior to reaction termination with 5 mM EDTA. Following the oxidation, samples were dialyzed overnight then worked up with 1 M piperidine at 90 °C for 2 h, and then the piperidine was removed by lyophilization. Next, the samples were resuspended in 12 µL of loading buffer (30% glycerol, 0.25% bromophenol blue, and 0.25% xylene cyanol) and 6 µL was loaded on a 20% denaturing PAGE gel, and electrophoresed at 75 W for 2.5 h. A Maxam-Gilbert G-lane was run alongside each reaction to determine the G oxidation sites.74 (link) The cleavage sites were observed and quantified by storage-phosphor autoradiography on a phosphorimager (see Supporting Information).
Oxidation products were determined by nuclease digestion followed by HPLC analysis. To achieve the analysis, reactions were conducted similarly to those described above with the exception of not adding the 5’-32P labeled strand. For each oxidant studied, 20 reactions were conducted and then combined to have 10 nmoles of oxidized ODN. Next, the samples were dialyzed overnight to remove the reaction buffer. Rose Bengal was removed with a NAP-25 column (GE Healthcare) following the manufacturer’s protocol. After concentrating the samples by lyophilization, they were resuspended in 50 µL of digestion buffer and digested with nuclease P1, snake venom phosphodiesterase and calf intestinal phosphatase, as previously described.32 (link) Next, the products were quantified by HPLC following a previously described protocol32 (link) for which the complete details of the entire process are described in the Supporting Information.
Fleming A.M, & Burrows C.J. (2013). G-Quadruplex Folds of the Human Telomere Sequence Alter the Site Reactivity and Reaction Pathway of Guanine Oxidation Compared to Duplex DNA. Chemical research in toxicology, 26(4), 593-607.
Publication 2013
Autoradiography Bromphenol Blue Buffers Cytokinesis Digestion Edetic Acid Freeze Drying Glycerin High-Performance Liquid Chromatographies Intestines Light Oxidants Peroxide, Hydrogen phosphodiesterase I, snake venom Phosphoric Monoester Hydrolases Phosphorus piperidine Riboflavin Rose Bengal xylene cyanol

Most recents protocols related to «Rose Bengal»

1
Retinal Vein Occlusion Mouse Model
Not available on PMC !

Example 2

In the following experiments, a mouse model of RVO, which induces reproducible retinal edema was used. RVO is the model that was used for testing anti-VEGF therapies for DME. Brown et al., Ophthalmology 117, 1124-1133 el 121 (2010); and Campochiaro et al., Ophthalmology 117, 1102-1112 e1101 (2010). I n this model, Rose Bengal, a photoactivatable dye, is injected into the tail veins of adult C57B16 mice and photoactivated by laser of retinal veins around the optic nerve head. A clot is formed and edema or increased retinal thickness develops rapidly. Inflammation, also seen in diabetes, also develops.

Fluorescein leakage and maximal retinal edema, measured by fluorescein angiography and optical coherence tomography (OCT), respectively, using the Phoenix Micron IV, is observed 24 h after RVO. Retinal edema is maintained over the first 3 days RVO. By day 4 the edema decreases and the retina subsequently thins out. In addition to edema formation there is evidence of cell death in the photoreceptor cell layer by day 2 after RVO.

In this example, mice were anesthetized with intra-peritoneal (IP) injection of ketamine and xylazine. One drop of 0.5% alcaine was added to the eye as topical anesthetic. The retina was imaged with the Phoenix Micron IV to choose veins for laser ablation using the Phoenix Micron IV image guided laser. One to four veins around the optic nerve head were ablated by delivering a laser pulse (power 50 mW, spot size 50 μm, duration 3 seconds) to each vein.

US11857609B2. Ocular delivery of cell permeant therapeutics for the treatment of retinal edema (2024-01-02). THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US]. Inventors: Carol M. Troy [US], Ying Y. Jean [US].
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Patent 2024
Adult Alcaine Cell Death Clotrimazole Diabetes Mellitus Edema Fluorescein Fluorescein Angiography Inflammation Injections, Intraperitoneal Ketamine Laser Ablation Mus Neoplasm Metastasis Optic Disk Photoreceptor Cells Pulse Rate Retina Retinal Edema Rose Bengal Tail Tomography, Optical Coherence Topical Anesthetics Vascular Endothelial Growth Factors Veins Veins, Central Retinal Vision Xylazine
2
Synthesis of X-Phodamine pH-Sensor 162
Not available on PMC !

Example 116

[Figure (not displayed)]

X-Phodamine PH-sensor 162. Aldehyde 159 (0.336 g, 1.0 mmol), 8-hydroxyjullolidine (0.416 g, 2.2 mmol), and 10-camphorsulfonic acid (20 mg, catalyst) were stirred for 18 h in propionic acid (10 mL) at 65-70° C., cooled to rt and poured into aqueous 3N NaOAc (200 mL) and sat. NaHCO3 (10 mL). The mixture was extracted with CHCl3 (7×40 mL), extract was washed with brine (200 mL), filtered through paper filter, and evaporated to give a crude dihydro derivative 161. A sample of this compound (40 mg, 0.06 mmol) was vigorously stirred in CHCl3 (50 mL) with Bengal Rose (10 mg, catalyst) in an open beaker under the sunlamp illumination for 18 h. After evaporation the residue was purified by preparative TLC on two silica gel plates using 7% H2O in MeCN as eluant to give compound 162 (11 mg, 24%) as a dark red solid.

US11867698B2. Fluorogenic pH sensitive dyes and their method of use (2024-01-09). Life Technologies Corporation [US]. Inventors: Jeffrey Dzubay [US], Kyle Gee [US], Vladimir Martin [US], Aleksey Rukavishnikov [US], Daniel Beacham [US].
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Patent 2024
10-camphorsulfonic acid 11-dehydrocorticosterone Aldehydes Anabolism Bicarbonate, Sodium brine Chloroform Lighting propionic acid Rhodamine Rose Bengal Silica Gel
3
Modeling Bovine Brucellosis Transmission in Rural India
The model is parametrized using data from a sero-survey of 425 dairy herds in rural Ludhiana district of Punjab conducted between 2015 and 2017; 139 herds had at least one positive animal (median within-herd prevalence 33.3%) [19 ]. These data are supplemented with information collected from a survey of 409 household herds [21 (link)] and published literature. Infection in a farm is seeded from the purchase of infected animals. Two zero-inflated negative binomial distributions for purchase numbers were fitted using maximum-likelihood estimation implemented with the R package fitdistrplus [24 (link)] to data on the number of purchases per farm per year; one for herds with less than nine adult females and one for herds with nine or more females. The effective contact (transmission) rate within a farm, β, was fitted using approximate Bayesian computation (ABC) techniques.
The model parameters are listed in table 1. As there was high uncertainty associated with the probability a calf born to an infected animal is infected θ and this could potentially influence which control strategies are considered most effective this parameter was varied as part of a scenario analysis. See table 1, electronic supplementary material and Holt et al. [13 (link)] for further details.

Model parameter definitions and values.

parameterdefinitionvaluesource
λcalving rate (and rate that exposed animals become infectious)0.605 per year[19 ]
γtransition rate between age groups1 per year
εjrate of purchasing new animals of age group jsampled for j = 4; 0 otherwiseestimated from observed data [19 ]
α1rate of removal of newborn calves (composite parameter capturing male calves, death and sale of calves)0.685 per year[19 ]
αjrate of removal of adults (composite parameter capturing death, sale and end of reproductive activity of adults)12/72 for j = 3 … 10 0.835 for j = 11estimated from age distribution [19 ]
βcattle-to-cattle effective contact (transmission) rate5.279this work
μrate of loss of infectiousness (composite rarameter capturing period bacteria are shed plus their survival in the environment)12/4 per year[25 (link),26 ]
θprobability calf born to infected animal is infected0.05 (0.2 in scenario analysis)[27 (link)–29 ]
ωcalves which are immune (proportion vaccinated ∗ VE)varied valueproportion vaccinated = 0.25; 0.5; 0.75 or 1.0 depending on scenario
φprobability that a purchased animal is vaccinatedvaried valueinitially 0, updated annually when simulating control strategies
Pprobability that a purchased animal is infectedinitially 0.151. Then varied as control strategies are implemented.[19 ]
VEvaccine efficacy0.8[30 (link)]
Setest sensitivity Rose Bengal test (RBT)0.9[31 (link)]
Sptest specificity RBT0.9
proportion of animals that are buffalo (versus cows)0.45[19 ]
Holt H.R., Walker M., Beauvais W., Kaur P., Bedi J.S., Mangtani P., Sharma N.S., Gill J.P., Godfroid J., McGiven J, & Guitian J. (2023). Modelling the control of bovine brucellosis in India. Journal of the Royal Society Interface, 20(200), 20220756.
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Publication 2023
Adult Age Groups Animals Bacteria Buffaloes Cattle Childbirth Females Households Hypersensitivity Infant, Newborn Infection Males Reproduction Rose Bengal Scheuermann's Disease Transmission, Communicable Disease Woman
4
Brucellosis Control through Test and Removal
Scenarios combining calfhood vaccination with testing of all animals (cows and buffalo of all age groups using the Rose Bengal test) and immediate removal of test positives were also simulated. Test and removal is assumed to occur at a single point in time, at the inception of the control programme (as proposed in the Brucella free village programme). There is no differentiate infected from vaccinated animals (DIVA) test available for brucellosis, therefore this strategy was not combined with vaccination at the inception of the programme. The number of true test positive animals is sampled from a Bernoulli distribution with the number of trials equal to Ej+ Ij and the probability of testing positive given by the test sensitivity, Se. False positive animals are also sampled from a Bernoulli distribution with number of trials equal to Sj and the probability of giving a false positive result equal to 1 − Sp. Scenario B was not simulated with test and removal as it was not considered an effective use of resources compared with Scenario C (see Results).
Targets for control were set using prevalence (percentage of infected animals in a village), as this is measurable via surveillance. Therefore, we define ‘control’ as animal-level prevalence below 1%, as indicative of a nominally low level of infection whereby Punjab could consider moving towards elimination. The ‘probability of control’ is the percentage of simulations with prevalence less than 1%. Predicted (cumulative) incidence, the percentage of animals infected with B. abortus per year, is also presented.
Holt H.R., Walker M., Beauvais W., Kaur P., Bedi J.S., Mangtani P., Sharma N.S., Gill J.P., Godfroid J., McGiven J, & Guitian J. (2023). Modelling the control of bovine brucellosis in India. Journal of the Royal Society Interface, 20(200), 20220756.
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Publication 2023
Age Groups Animals Brucella Brucellosis Buffaloes Cattle Fetuses, Aborted Hypersensitivity Infection Rose Bengal Vaccination
5
Measuring Surface Hydrophobicity of Microparticles
The surface hydrophobicity of MT-BHC MPs and MT-BHC SLNs was measured using the Rose Bengal (RB) binding method (Doktorovova et al., 2012 (link)). Different volumes of BHC solution, MT-BHC SLNs, and MT-BHC MPs were taken, and double the volume of RB solution (30 μg mL−1) was added. After incubating for 2 h away from light at room temperature, the mixture was centrifuged at 15,000 rpm for 30 min. Afterward, the sample was filtered (0.22 μm) and the free RB in the supernatant was measured using UV spectrophotometry. The RB concentration was determined using the following formula:
ra=KN−Kr
where r is the concentration of RB bound to the particles, a is the concentration of RB at equilibrium, K is the binding constant to evaluate the hydrophobicity of the particle surface, and N is the maximum binding amount of RB.
Li H., Dai F., Liu H., Tao Q., Hu J., Zhang Y., Xiao Z., Rupenthal I.D., Li H., Yang F., Li W., Lin H, & Hou D. (2023). Physicochemical properties and micro-interaction between micro-nanoparticles and anterior corneal multilayer biological interface film for improving drug delivery efficacy: the transformation of tear film turnover mode. Drug Delivery, 30(1), 2184312.
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Publication 2023
Light Rose Bengal Spectrophotometry

Top products related to «Rose Bengal»

1
Rose bengal by Merck Group
Sourced in United States, Germany, United Kingdom, Australia, China, Japan, Sao Tome and Principe
Rose Bengal is a laboratory dye used as a reagent in various analytical and diagnostic applications. It is a red, crystalline powder that is soluble in water and certain organic solvents. Rose Bengal is commonly used as a staining agent in cell biology, histology, and ophthalmology procedures.
2
Kl1500 lcd by Zeiss
Sourced in Germany
The KL1500 LCD is a compact and versatile LED cold light source from Zeiss. It features a color temperature of 5,000 K and an adjustable light intensity. The KL1500 LCD is designed for use with a variety of microscopes and other lab equipment.
3
Rose bengal solution by Merck Group
Sourced in United States
Rose Bengal solution is a laboratory reagent used in various scientific procedures. It is a red dye that exhibits specific chemical and optical properties. The solution can be utilized in various analytical and diagnostic applications, such as staining and visualization techniques. The core function of the Rose Bengal solution is to provide a colorimetric indicator for specific applications, without further interpretation or extrapolation on its intended use.
4
Rose bengal by Thermo Fisher Scientific
Sourced in United States, Germany
Rose Bengal is a water-soluble dye commonly used as a staining agent in various laboratory applications. It is a synthetic organic compound with the chemical formula C₂₀H₄Cl₄I₄NaO₅. Rose Bengal is known for its intense red-pink color and is often used to enhance visual contrast in microscopy, cell and tissue staining, and other analytical techniques.
5
Rose bengal dye by Merck Group
Sourced in United States, Germany
Rose Bengal dye is a fluorescent, water-soluble compound used as a coloring agent in various laboratory applications. It is commonly employed in staining techniques, particularly in microscopy, to enhance the contrast and visibility of biological samples.
6
Sodium hydroxide (naoh) by Merck Group
Sourced in Germany, United States, India, United Kingdom, Italy, China, Spain, France, Australia, Canada, Poland, Switzerland, Singapore, Belgium, Sao Tome and Principe, Ireland, Sweden, Brazil, Israel, Mexico, Macao, Chile, Japan, Hungary, Malaysia, Denmark, Portugal, Indonesia, Netherlands, Czechia, Finland, Austria, Romania, Pakistan, Cameroon, Egypt, Greece, Bulgaria, Norway, Colombia, New Zealand, Lithuania
Sodium hydroxide is a chemical compound with the formula NaOH. It is a white, odorless, crystalline solid that is highly soluble in water and is a strong base. It is commonly used in various laboratory applications as a reagent.
7
Rose bengal rb by Merck Group
Sourced in United States, China
Rose Bengal (RB) is a synthetic dye used as a laboratory reagent. It is a pink crystalline powder that is soluble in water and alcohol. RB is commonly used as a stain for microscopy and diagnostic applications.
8
Plate count agar by Hopebio
Sourced in China
Plate count agar is a solid culture medium used for the enumeration of viable microorganisms in a sample. It provides a nutritious environment for the growth and development of bacterial colonies, enabling the quantification of microbial populations.
9
Dimethyl sulfoxide (dmso) by Merck Group
Sourced in United States, Germany, United Kingdom, China, Italy, Sao Tome and Principe, France, Macao, India, Canada, Switzerland, Japan, Australia, Spain, Poland, Belgium, Brazil, Czechia, Portugal, Austria, Denmark, Israel, Sweden, Ireland, Hungary, Mexico, Netherlands, Singapore, Indonesia, Slovakia, Cameroon, Norway, Thailand, Chile, Finland, Malaysia, Latvia, New Zealand, Hong Kong, Pakistan, Uruguay, Bangladesh
DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.
10
Stereotactic frame by Kopf Instruments
Sourced in United States, Germany
The Stereotactic Frame is a medical device used in neurosurgical procedures. It provides a three-dimensional coordinate system to precisely locate and target specific areas within the brain. The frame is attached to the patient's head, allowing for accurate and minimally invasive access to the targeted region.

More about "Rose Bengal"

Rose Bengal is a synthetic dye with diverse medical and scientific applications.
This red, water-soluble compound is commonly used as a photodynamic therapy agent, a diagnostic tool in ophthalmology, and a stain for biological samples.
It has also been utilized in the KL1500 LCD display technology.
Rose Bengal solution, a combination of Rose Bengal dye and solvents like sodium hydroxide or DMSO, is frequently employed in research and clinical settings.
Researchers can leverage PubCompare.ai's AI-driven platform to easily locate protocols from literature, preprints, and patents, while receiving insightful comparisons to identify the most accurate and reproducible methods for their Rose Bengal-related studies.
This enhances research efficiency and saves time-consuming manual searches.
Beyond its medical and scientific uses, Rose Bengal (also known as RB) has found applications in plate count agar, a medium used for culturing and enumerating microorganisms.
By optimizing their Rose Bengal research workflow, scientists can gain a deeper understanding of this versatile dye and its diverse applications, ultimately accelerating scientific discoveries and advancements in various fields.