Example 5
Table 5 further demonstrated the synergistic effect between organic acids and amino acid based surfactant against M. smegmatis under the EPA standard according to the OECD Quantitative Methods for Evaluating the Activity of Microbicides. The organic acids were a mixture of salicylic acid, lactic acid, and formic acid (at 0.3% weight, 1.9% weight, and 1.0% weight, respectively, based on total weight of the formulation). The amino acid based surfactant was sodium sarcosinate, and the stabilizing agent was PnB.
Formulation K showed that the high efficacy against M. smegmatis were achieved even without the use of hydrogen peroxide in the formulation.
Example 3
Table 3 showed the micro efficacy of the tested disinfectant formulations against S. aureus based on the EPA standard according to the OECD Quantitative Methods for Evaluating the Activity of Microbicides.
A very strong synergistic effect between C1-8 organic acids and amino acid based surfactant against S. aureus was observed in the disinfectant Formulation C, wherein the organic acids were a mixture of salicylic acid and lactic acid (at 0.4% weight and 2.2% weight, respectively, based on total weight of the formulation), the amino acid based surfactant was a sodium salt of N-lauroyl sarcosinate (hereinafter “Sodium sarcosinate”), and the stabilizing agent was ethanol. Formulation D showed that the high efficacy against S. aureus were achieved even without the use of hydrogen peroxide in the formulation.
Example 10
Table 10 below showed that the disinfectant compositions of Formulation DD was obtained at high level of salicylic acid (e.g., above 2% weight based on total weight of the formulation), with high stability and excellent antimicrobial efficacy. The micro efficacy of the disinfectant formulation was determined based on the EPA standard according to the OECD Quantitative Methods for Evaluating the Activity of Microbicides.
Example 4
M. smegmatis was known as the surrogate strain for M. tuberculosis. The micro efficacy of the disinfectant formulation was determined based on the EPA standard according to the OECD Quantitative Methods for Evaluating the Activity of Microbicides. Table 4 demonstrated the synergistic effect between C1-8 organic acids and amino acid based surfactant against M. smegmatis, wherein the organic acids were a mixture of salicylic acid and lactic acid (at 0.4% weight and 2.2% weight, respectively, based on total weight of the formulation), and the amino acid based surfactant was sodium sarcosinate.
