> Chemicals & Drugs > Organic Chemical > Sodium Carboxymethylcellulose

Sodium Carboxymethylcellulose

Sodium Carboxymethylcellulose is a semisynthetic, water-soluble polymer derived from cellulose.
It is used in a variety of applications, including as a thickening, stabilizing, and suspending agent in pharmaceuticals, cosmetics, and food products.
The compound has been studied for its potential therapeutic uses, such as in the management of dry eye disease and as a wound dressing.
Reserachers can use PubCompare.ai to optimize their sodium carboxymethylcellulose research protocols, locating the best methods from literature, preprints, and patents, and comparing them to identify the most effective appproaches for improved reproducibility and accuracy.

Most cited protocols related to «Sodium Carboxymethylcellulose»

Anesthetic Effects on Cortical Pathology

The animal protocol was approved by Standing Committee on Animals at Massachusetts General Hospital. C57/BL6 mice (The Jackson Laboratory, Bar Harbor, ME) were randomly assigned to an anesthesia or control group. Mice randomized to the anesthesia group received 1.4% isoflurane in 100% oxygen for 2 hours in an anesthetizing chamber whereas the control group received 100% oxygen at an identical flow rate for 2 hours in an identical chamber. The mice breathed spontaneously, and anesthetic and oxygen concentrations were measured continuously (Datex, Tewksbury, MA). Temperature of the anesthetizing chamber was controlled to maintain rectal temperature of the animals at 37 ± 0.5°C. Mean arterial blood pressure was measured non-invasively using a tail cuff (Kent Scientific Corporation, Torrington, CT) in the anesthetized mice. Isoflurane anesthesia did not significantly affect blood pressure and blood gas of mice (Data not shown). Anesthesia was terminated by discontinuing isoflurane and placing animals in a chamber containing 100% oxygen until 20 minutes after return of righting reflex. They were then returned to individual home cages until sacrifice. Mice were sacrificed by decapitation two, six, 12, and 24 hours after isoflurane anesthesia. The brain was removed rapidly and prefrontal cortex was dissected out and frozen in liquid nitrogen for subsequent processing for determinations of caspase activation, levels of BACE and Aβ. For interaction studies, CQ (30mg/kg/day, in 0.05% carboxymethylcellulose sodium) was given by daily gavage for 7 days 19 (link). Then mice were treated with 1.4% isoflurane for 2 hours, and were sacrificed six hours after the anesthesia.

Xie Z., Culley D.J., Dong Y., Zhang G., Zhang B., Moir R.D., Frosch M.P., Crosby G, & Tanzi R.E. (2008). The common inhalation anesthetic isoflurane induces caspase activation and increases Aβ level in vivo. Annals of neurology, 64(6), 618-627.

Publication 2008

Anesthesia Anesthetics Animals BLOOD Blood Pressure Brain Caspase Decapitation Freezing Isoflurane Mice, House Nitrogen Oxygen Oxygen-20 Prefrontal Cortex Rectum Reflex, Righting Sodium Carboxymethylcellulose Tail Tube Feeding

Biochemical Analysis of Biomolecular Samples

Protocol full text hidden due to copyright restrictions

Open the protocol to access the free full text link

Publication 2018

Acetate Acetic Acid Acetone Adenosine Monophosphate Ammonium C.I. 42655 Chlorine Chloroform Cytidine Monophosphate Deoxycholic Acid dinitrophenylhydrazine Dithiothreitol DNA Fingerprinting Edetic Acid Ethanol ethyl acetate Glucose Guanidine hen egg lysozyme Hexanes High-Performance Liquid Chromatographies Hydrochloric acid Hypochlorite Inferior Colliculus Iron Methanol Mucosa, Gastric Pepsin A Peroxide, Hydrogen Phenol Phosphates Pigs Salmo salar Serum Albumin, Bovine Sodium sodium borohydride Sodium Carboxymethylcellulose Sodium Chloride Sodium Hydroxide Streptomycin Sulfate Sulfate, Sodium Dodecyl Sulfates, Inorganic Thymidine Monophosphate Trichloroacetic Acid triphosphate Tromethamine Urea

Fabrication and Coating of Microneedle Vaccine Patches

Protocol full text hidden due to copyright restrictions

Open the protocol to access the free full text link

Publication 2009

Antigens, Viral Bath Cadaver Charcoal Cichorium intybus Dahlia Dextrans Diagnosis Ethics Committees, Research Glucose Glycerin Homo sapiens Inulin Lutrol Medical Devices Metals Microscopy Microscopy, Fluorescence Needles Obstetric Delivery Olivary Nucleus Phosphates Phosphoric Acids Plant Tubers Saline Solution Scanning Electron Microscopy Skin Sodium Carboxymethylcellulose Sodium Chloride Sucrose Tissues Trehalose Vaccines Virus

Cellulase Production and Enzymatic Characterization

Cellulase was produced in a 500 mL flask that contained 100 mL of fluid medium through a two-step cultivation procedure. Strains were first grown at 30°C in 100 mL of medium that contained 2 g of glucose as a carbon source and were then regulated at pH 5.5 and 200 rpm for 20 hours. The cultures were collected through vacuum drum filtration during this second step, and 0.5 g vegetative mycelia was added to 100 mL of Vogel’s medium that contained 2% cellulose as carbon source or wheat bran medium at an initial pH of 5.5 at 30°C and 200 rpm. Culture supernatants (crude enzyme) were diluted with sodium acetate buffer solution (SABF, 0.2 M, pH 4.8). Enzymatic hydrolyses of the polysaccharides were also performed in SABF (0.2 M, pH 4.8). The filter paper enzyme (FPA), endoglucanase (CMCase), xylanase, and amylase activities of the culture supernatants (diluted samples) were assayed using a DNS reagent (10 g 3, 5-dinitrosalicylic acid, 20 g sodium hydroxide, 200 g sodium potassium tartrate, 2.0 g redistilled phenol, and 0.50 g sodium sulfite anhydrous per 1000 mL DNS reagent) against Whatman No. 1 filter paper, carboxymethylcellulose sodium salt (CMC-Na), xylan (from beechwood), and soluble starch. CMC-Na, xylan, or starch was dissolved in SABF to a final concentration of 1% (mass/volume percent, m/v %), and then the mixture was left overnight and was shaken well before using. The following components were added in a 2.0 mL reaction mixture: 0.5 mL diluted culture supernatants and 1.5 mL CMC-Na, xylan, or starch solution for CMCase, xylanase, or amylase activity assays, respectively; and 2.0 mL diluted culture supernatants and 50 mg Whatman No. 1 filter paper for FPA assay into 25 mL colorimetric tube. The mixture was mixed gently and the reaction mixture was incubated for FPA measurement in a 50°C water bath for 1 hour, for CMCase and xylanase activity measurements at 50°C for 30 min, and for amylase activity measurement at 40°C for 10 min. Three milliliters of DNS reagent were then added to stop the reaction. A blank tube (with boiled crude enzyme) was used as control to correct any reducing sugar present in the crude enzyme samples. The tubes were placed in boiling water for 10 min, 20 mL distilled water was added, 200 μL of reaction mixture was pipetted, and the absorbance was determined at 540 nm. The cellobiohydrolase (pNPCase) and β-glucosidase (pNPGase) activities were measured by using 4-Nitrophenyl β-D-cellobioside (pNPC) and 4-Nitrophenyl β-D-glucopyranoside (pNPG) as substrates, respectively. The pNPC or pNPG was dissolved in SABF to a final concentration of 1 mg/mL. Moreover, 50 μL of pNPC solution (containing 1 mg/mL D-Glucono-δ-lactone) or 50 μL of pNPG solution and 100 μL of diluted culture supernatants were mixed, and then the mixtures were incubated in a 50°C water bath for 30 min. The reaction was stopped by adding 0.15 mL of sodium carbonate solution (10%, m/v), then 200 μL of these reaction mixtures was pipetted, and the absorbance was measured at 420 nm. One unit of enzyme activity was defined as the amount of enzyme required to release 1 μmol of glycoside bonds of the substrate per minute under defined assay conditions. Independent triplicate cultures were sampled and analyzed.
The total protein was determined using a Bradford assay kit according to the instructions of the manufacturer.

Li Z., Yao G., Wu R., Gao L., Kan Q., Liu M., Yang P., Liu G., Qin Y., Song X., Zhong Y., Fang X, & Qu Y. (2015). Synergistic and Dose-Controlled Regulation of Cellulase Gene Expression in Penicillium oxalicum. PLoS Genetics, 11(9), e1005509.

Full text: Click here

Publication 2015

4-nitrophenyl 4-nitrophenyl beta-cellobioside 4-nitrophenylgalactoside Acids Amylase Bath beta-Glucosidase Biological Assay Buffers Carbohydrates Carbon carboxymethylcellulase Cardiac Glycosides Cellulase Cellulose Colorimetry enzyme activity Enzymes Exo-Cellobiohydrolase Filtration Glucose Hydrolysis Lactones Mycelium Phenol Polysaccharides Proteins Sodium Acetate sodium carbonate Sodium Carboxymethylcellulose Sodium Chloride Sodium Hydroxide sodium potassium tartrate sodium sulfite Starch Strains Vacuum Wheat Bran Xylanase C Xylans

Cellulose Hydrolysis Optimization Protocol

The soil sample suspensions were inoculated on Czapek's medium [17 (link)] containing sugarcane bagasse pulp (in g/L: NaNO₃, 2; MgSO₄·7H₂O, 0.5; NaCl, 0.5; FeSO₄·7H₂O, 0.01; KH₂PO₄, 1.0; yeast extract, 0.4; pulp, 5 (containing 80% water); and agar, 15.0; pH 5.0) and incubated at 28°C. Subsequently, single colonies were picked using an inoculating needle and inoculated onto Mandels and Reese medium [18 (link)] containing carboxymethyl cellulose sodium salt (CMC-Na; in g/L: KH₂PO₄, 2.0; (NH₄)₂SO₄, 1.4; MgSO₄·7H₂O, 0.3; CaCl_2, 0.3; yeast extract, 0.4; FeSO₄·7H₂O, 0.005; MnSO₄, 0.0016; ZnCl₂, 0.0017; CoCl₂, 0.002; CMC-Na, 5.0; and agar, 15.0; pH 5.0). After incubation at 28°C for 48 h, all the plates were stained with 1% (w/v) Congo-red solution for 15 min and discolored with 1 M NaCl for 15 min [19 (link)]. The degradation zones were visible around the bacteria, showing that the strains could hydrolyze CMC.
The modified Mandels medium (also called basal medium) used for CMCase production by the isolates contained the following components (in g/L: KH₂PO₄, 1.5; Na₂HPO₄·7H₂O, 2.5; (NH₄)₂SO₄, 1.5; MgSO₄·7H₂O, 0.3; CaCl₂, 0.1; FeSO₄·7H₂O, 0.005; MnSO₄, 0.0016; ZnCl₂, 0.0017; and CoCl₂, 0.002; pH 7.0). The bacterial isolates were precultured overnight in general bacteria medium (in g/L: beef extract, 2; yeast extract, 2; sucrose, 6; and peptone, 5) at 28°C and 180 rpm. Subsequently, 2 mL of the culture was inoculated into 250 mL conical flask containing 50 mL of basal medium with 10 g/L of CMC-Na as the sole carbon source and incubated at 28°C and 180 rpm for 60 h.

Liang Y.L., Zhang Z., Wu M., Wu Y, & Feng J.X. (2014). Isolation, Screening, and Identification of Cellulolytic Bacteria from Natural Reserves in the Subtropical Region of China and Optimization of Cellulase Production by Paenibacillus terrae ME27-1. BioMed Research International, 2014, 512497.

Full text: Click here

Publication 2014

Agar Bacteria bagasse Beef Carbon carboxymethylcellulase Dental Pulp Needles Peptones Saccharum Sodium Carboxymethylcellulose Sodium Chloride Strains Sucrose Sulfate, Magnesium Yeasts

Most recents protocols related to «Sodium Carboxymethylcellulose»

Tretinoin-Based Topical Gel Formulation

Not available on PMC !

Example 4

A composition comprising Tretinoin as active ingredient:

IngredientConcentration (w/w %)

Oleic acid5.00

Isopropanol10.00

BHT (Butylated Hydroxytoluene)0.02

Sorbic acid0.10

Tretinoin0.10

Silica microspheres0.70

CMC Na (carboxymethyl cellulose sodium)2.40

Natrosol (HBC)0.50

Glycerin5.00

Benzyl alcohol0.80

Poloxamer 4070.20

P. Waterq.s. 100%

The process for the preparation of the composition was as follows:

- 1. CMC Na (carboxymethyl cellulose sodium) and Natrosol (HEC) were dispersed in water until a clear gel was formed
- 2. Glycerin and benzyl alcohol were added to stage 1 and mixed;
- 3. Oleic acid, isopropanol, BHT, sorbic acid, Poloxamer 407 and tretinoin were heated to 50° C. while stirring until clear solution was obtained. Then the solution was cooled to the room temperature;
- 4. Silica Microspheres were added to the cooled oily phase and resultant mixture was stirred for at least one hour;
- 5. Stage 4 was added to the stage 2 and stirred for one hour under vacuum.

An opaque yellowish gel was obtained.

US11865208B2. Pharmaceutical compositions comprising silica microspheres (2024-01-09). SOL-GEL TECHNOLOGIES LTD. [IL]. Inventors: Marina Shevachman [IL], Amira Ze' Evi [IL], Eilon Asculai [IL], Batella Benyaminovich [IL], Nir Avram [IL], Chaim Aschkenasy [IL].

Full text: Click here

Patent 2024

Benzyl Alcohol Ethanol Glycerin Isopropyl Alcohol Microspheres Oils Oleic Acid Pharmaceutical Preparations Poloxamer 407 Silicon Dioxide Sodium Carboxymethylcellulose Sorbic Acid Tretinoin Vacuum

Foliar Nutritional Composition for Indoor Plants

Not available on PMC !

Example 2

3.5 grams of pine needle essential oil, 20 grams of hydroxypropyl beta cyclodextrin, 3692 grams of Harrell's 8-2-4 liquid fertilizer concentrate liquid fertilizer concentrate, 2.0 grams of humic acid 4.75 grams hemp sap, 80 grams sodium carboxymethylcellulose, 2 drops of color concentrate, and 0.25 grams of nonionic surfactant were combined using a high-speed mixer to produce one gallon of plant treatment concentrate composition. 4 milliliters of the resulting plant treatment concentrate were transferred to a 118 ml. bottle and deionized water was added until filled. A trigger spray top dispenser was added to provide a fragrant foliar nutritional composition for applying to the leaves and stem of an indoor plant.

US11864560B2. Fragrant plant treatment compositions (2024-01-09). None [US]. Inventors: Richard Thomas Johnston [US].

Full text: Click here

Patent 2024

2-Hydroxypropyl-beta-cyclodextrin Elk3 protein, human Hemp Humic Acids Needles Oils, Volatile Pinus Plants Precipitating Factors Scents Sodium Carboxymethylcellulose Stem, Plant Surface-Active Agents

Topiramate Oral Liquid Suspension Formulation

Not available on PMC !

Example 1

An oral liquid suspension containing topiramate was formulated from the following substances in the amounts specified.

% W/V (mg/ml)Material/Component

2.5topiramate

0.1methylparaben

0.03sodium benzoate powder

0.08saccharin sodium dihydrate powder

0.25sodium phosphate dibasic

3sorbitol solution 70%

2.25propylene glycol

5glycerin 99% natural grade

1.26PROSOLV ® SMCC 50 (silicified

microcrystalline cellulose)

0.18carboxymethylcellulose sodium, medium viscosity

(2% aqueous solution at 25° C. is 400-800 cps)

0.18xanthan gum

79.67purified water

5polyethylene glycol 400

0.5sucralose

0.2cherry flavor (natural and artificial)

0.002FD&C red #40

0.0002FD&C yellow #6

TOTAL

100.2

Example 2

The oral liquid suspension containing topiramate of Example 1 was manufactured as follows.

Phase 1 Preparation;

- 1. Mix propylene glycol and methylparaben until completely dissolved and homogeneous.
  Phase 2 Preparation:
- 1. Mix water, sodium carboxymethyl cellulose, xanthan gum, and PROSOLV® SMCC 50M (microcrystalline cellulose and colloidal silicon dioxide) until completely dissolved and homogeneous.
- 2. Add sodium benzoate, sodium phosphate dibasic, and sodium saccharin and mix until completely dissolved and homogeneous.
- 3. Add polyethylene glycol; and mix until completely dissolved and homogeneous.
- 4. Add sorbitol, 70% solution and mix until completely dissolved and homogeneous.
- 5. Add topiramate and mix until completely dissolved and homogeneous.
  Phase 3 Preparation:
- 1. Add Phase 1 into Phase 2 with continuous mixing, until completely dissolved and homogeneous.
- 2. Add glycerin and mix until completely dissolved and homogeneous.
- 3. Add FD&C Red #40, FD&C Yellow #6, cherry flavor, and sucralose; and mix until completely dissolved and homogeneous.
- 4. Semi-automatic fill in packaging (bottle) and manual labeling.
- 5. Optionally check appearance, pH, viscosity, particle size distribution (PSD), assay, dosage uniformity, sedimentation rate, dissolution, deliverable volume, and/or micro testing.

Example 3

The oral liquid suspension of Example 1 was manufactured for packaging, shipment, storage, and for use with the following.

ContainerOral Dispenser

Plastic bottleMeasuring cup

Glass bottleMeasuring syringe

Measuring dropper

Example 4

The oral liquid suspension of Example 1 was formulated for administration that includes the following.

- 1. Shake well before using to ensure sufficient redispersion and content uniformity.
- 2. Measure the prescribed dose of the oral liquid suspension into the dispenser.
- 3. Orally administer the dose from the dispenser to the subject (with or without food). The medication may be administered by the patient, a caregiver, or a health professional.

US11872309B2. Topiramate oral liquid suspension and use thereof (2024-01-16). OWP Pharmaceuticals, Inc. [US]. Inventors: Paul Sudhakar [US], Scott Boyer [US].

Full text: Click here

Patent 2024

Allura Red AC Dye Benzoate Biological Assay C.I. 15-985 Flavor Enhancers Food Glycerin Health Care Professionals methylparaben methylparaben, sodium salt microcrystalline cellulose Patients Pharmaceutical Preparations Phosphates polyethylene glycol 400 Polyethylene Glycols Powder Propylene Glycol Prunus cerasus Saccharin Sodium Silicon Dioxide Sodium Benzoate Sodium Carboxymethylcellulose sodium phosphate Sorbitol sucralose Syringes Topiramate Tremor Viscosity xanthan gum

Lignosulfonate-Polyamine Composite Synthesis

Not available on PMC !

Example 1

Calcium lignosulfonate (Borrement CA 2120) was provided by Borregaard LignoTech. Sodium lignosulfonate was purchased from Aldrich, and ammonium lignosulfonate was obtained from TemBac.

Sodium carboxymethylcellulose (NaCMC), hydroxypropylcellulose (HPC) and hydroxyethylcellulose (HEC) were obtained from Aldrich and showed a Mw of approx. 250 kDa, 100 kDa and 100 kDa, respectively.

The amine functional material such as hexamethylene diamine (HMDA) and diethylenetriamine (DETA) were obtained from Aldrich. Different types of polyethylenimines (Lupasol® EO, Lupasol® PS, Lupasol® P and Lupasol® G100), polyvinyl amines (Luredur® VM, Luredur® VH and Luredur® VI), were obtained from BASF Chemical Company, and polyetheramines (JeffamineED600, JeffamineEDR148, JeffamineT403) from Huntsman Holland BV.

The required amounts of polymer and lignosulfonate (LS) were dissolved in water individually. The required amount of polyamine functional compound was added to the LS solution followed by homogenization. The polymer solution and LS-amine solution were then combined at ambient temperature and stirred at 500 rpm for 30 minutes.

US11879063B2. Binder compositions and uses thereof (2024-01-23). KNAUF INSULATION SPRL [BE], KNAUF INSULATION, INC. [US]. Inventors: Carl Hampson [GB], Ferdous Khan [GB].

Full text: Click here

Patent 2024

Amines Ammonium calcium lignosulfonate Cyclohexane Diamines diethylenetriamine hydroxyethylcellulose hydroxypropylcellulose lignosulfonates Polyamines Polyethyleneimine Polymers Polyvinyls Sodium Sodium Carboxymethylcellulose TLR4 agonist G100

Standardized Mouse Models for Pulmonary Hypertension

All animal experiments were approved by the Institutional Animal Care and Use Committee at Acceleron Pharma Inc., a subsidiary of Merck & Co., Inc., Rahway, NJ, USA and performed in accordance with the guidelines from the NIH Guide for the Care and Use of Laboratory Animals. Male C57BL/6 mice (10 weeks old, Jackson Laboratory) were used for TAC and MI models as described (18 (link), 22 (link)), and male Balb/c mice (10 weeks old, Jackson Laboratory) were used for the prolonged TAC model to establish PH. Male obese ZSF1 rats (8 and 23 weeks old) and their lean littermates (Charles River, Wilmington, MA, USA) were used for the PH-HFpEF study. PH was established by a single subcutaneous injection of a vascular endothelial growth factor receptor antagonist, Sugen 5416 (SU5416, 100 mg/kg; Cayman), suspended in CMC buffer (0.5% sodium carboxymethyl cellulose, 0.4% polysorbate 80, 0.9% sodium chloride, and 0.9% benzyl alcohol) (23 (link), 24 (link)). Animals were euthanized in all experiments by heart and lung removal en bloc according to AVMA guidelines.

Joshi S.R., Atabay E.K., Liu J., Ding Y., Briscoe S.D., Alexander M.J., Andre P., Kumar R, & Li G. (2023). Sotatercept analog improves cardiopulmonary remodeling and pulmonary hypertension in experimental left heart failure. Frontiers in Cardiovascular Medicine, 10, 1064290.

Full text: Click here

Publication 2023

Animals Animals, Laboratory Benzyl Alcohol Buffers Caimans Heart Institutional Animal Care and Use Committees Lung Males Mice, Inbred BALB C Mice, Inbred C57BL Obesity Polysorbate 80 Rattus norvegicus Rivers Sodium Carboxymethylcellulose Sodium Chloride SU 5416 Vascular Endothelial Growth Factor Receptor

Top products related to «Sodium Carboxymethylcellulose»

Sodium carboxymethyl cellulose by Merck Group

Sourced in United States, Germany, Sao Tome and Principe, India, Poland, United Kingdom, Denmark

Sodium carboxymethyl cellulose is a water-soluble, cellulose-based polymer. It is a white or off-white powder with no odor. The primary function of sodium carboxymethyl cellulose is to act as a thickening, suspending, and stabilizing agent in various applications.

Carboxymethylcellulose sodium salt by Merck Group

Sourced in United States, France, Germany, Italy

Carboxymethylcellulose sodium salt is a cellulose derivative that is used as a thickening, stabilizing, and suspending agent in various applications. It is a white to off-white powder or granular material that is soluble in water and forms viscous solutions. The core function of this product is to modify the rheological properties of aqueous systems.

Dimethyl sulfoxide (dmso) by Merck Group

Sourced in United States, Germany, United Kingdom, China, Italy, Sao Tome and Principe, France, Macao, India, Canada, Switzerland, Japan, Australia, Spain, Poland, Belgium, Brazil, Czechia, Portugal, Austria, Denmark, Israel, Sweden, Ireland, Hungary, Mexico, Netherlands, Singapore, Indonesia, Slovakia, Cameroon, Norway, Thailand, Chile, Finland, Malaysia, Latvia, New Zealand, Hong Kong, Pakistan, Uruguay, Bangladesh

DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.

Sodium carboxymethyl cellulose na cmc by Merck Group

Sourced in United States, Ireland, China

Sodium carboxymethyl cellulose (Na-CMC) is a water-soluble cellulose derivative. It is a white to off-white, odorless, and tasteless powder. Na-CMC is widely used as a thickening, stabilizing, and emulsifying agent in various industries, including food, pharmaceuticals, and personal care products.

Cmc na by Merck Group

Sourced in United States, China, Germany, United Kingdom, Macao

CMC-Na is a sodium carboxymethylcellulose product. It is a white, odorless, and tasteless powder. CMC-Na is a water-soluble polymer derived from cellulose. It serves as a thickening, emulsifying, and stabilizing agent in various applications.

Carboxymethylcellulose sodium by Merck Group

Sourced in United States, Germany

Carboxymethylcellulose sodium is a water-soluble anionic cellulose derivative commonly used as a thickening, stabilizing, and suspending agent in various products. It is a white to off-white powder with a sodium content of approximately 8%. The compound acts as a viscosity modifier and is utilized in a range of applications, including pharmaceutical, food, and industrial formulations.

Acetonitrile by Merck Group

Sourced in Germany, United States, Italy, India, China, United Kingdom, France, Poland, Spain, Switzerland, Australia, Canada, Brazil, Sao Tome and Principe, Ireland, Belgium, Macao, Japan, Singapore, Mexico, Austria, Czechia, Bulgaria, Hungary, Egypt, Denmark, Chile, Malaysia, Israel, Croatia, Portugal, New Zealand, Romania, Norway, Sweden, Indonesia

Acetonitrile is a colorless, volatile, flammable liquid. It is a commonly used solvent in various analytical and chemical applications, including liquid chromatography, gas chromatography, and other laboratory procedures. Acetonitrile is known for its high polarity and ability to dissolve a wide range of organic compounds.

Acetonitrile by Thermo Fisher Scientific

Sourced in United States, United Kingdom, China, Belgium, Germany, Canada, Portugal, France, Australia, Spain, Switzerland, India, Ireland, New Zealand, Sweden, Italy, Japan, Mexico, Denmark

Acetonitrile is a highly polar, aprotic organic solvent commonly used in analytical and synthetic chemistry applications. It has a low boiling point and is miscible with water and many organic solvents. Acetonitrile is a versatile solvent that can be utilized in various laboratory procedures, such as HPLC, GC, and extraction processes.

Fetal bovine serum (fbs) by Thermo Fisher Scientific

Sourced in United States, China, United Kingdom, Germany, Australia, Japan, Canada, Italy, France, Switzerland, New Zealand, Brazil, Belgium, India, Spain, Israel, Austria, Poland, Ireland, Sweden, Macao, Netherlands, Denmark, Cameroon, Singapore, Portugal, Argentina, Holy See (Vatican City State), Morocco, Uruguay, Mexico, Thailand, Sao Tome and Principe, Hungary, Panama, Hong Kong, Norway, United Arab Emirates, Czechia, Russian Federation, Chile, Moldova, Republic of, Gabon, Palestine, State of, Saudi Arabia, Senegal

Fetal Bovine Serum (FBS) is a cell culture supplement derived from the blood of bovine fetuses. FBS provides a source of proteins, growth factors, and other components that support the growth and maintenance of various cell types in in vitro cell culture applications.

Carboxymethylcellulose sodium salt cmc by Merck Group

Sourced in Italy, United States

Carboxymethylcellulose sodium salt (CMC) is a water-soluble polymer derived from cellulose. It is used as a thickening, suspending, and stabilizing agent in various laboratory applications.

What are the common uses of Sodium Carboxymethylcellulose?

Sodium Carboxymethylcellulose (also known as CMC or cellulose gum) is a versatile compound with a wide range of applications. It is commonly used as a thickening, stabilizing, and suspending agent in pharmaceuticals, cosmetics, and food products. CMC is particularly useful for improving the texture and consistency of various formulations, helping to prevent separation or settling of ingredients. Additionally, researchers have explored its potential therapeutic uses, such as in the management of dry eye disease and as a wound dressing material.

How does Sodium Carboxymethylcellulose differ from other types of cellulose derivatives?

Sodium Carboxymethylcellulose is a semisynthetic, water-soluble polymer derived from cellulose. It differs from other cellulose derivatives in its chemical structure and properties. For example, Hydroxyethylcellulose (HEC) and Hydroxypropylcellulose (HPC) are also cellulose-based polymers, but they have different functional groups and characteristics that make them suitable for distinct applications. The unique properties of CMC, such as its thickening ability and compatibility with a wide range of pH levels, make it a preferred choice for specific formulations and uses compared to other cellulose derivatives.

What are some of the challenges in working with Sodium Carboxymethylcellulose?

One of the main challenges in working with Sodium Carboxymethylcellulose is ensuring consistent quality and performance across different batches or sources. CMC can vary in its degree of substitution, molecular weight, and other physicochemical properties, which can impact its functionality in a given application. Researchers may need to carefully evaluate and optimize the CMC characteristics to achieve the desired rheological, stability, and other properties in their formulations. Additionally, the hygroscopic nature of CMC can make it challenging to handle and incorporate into some dyr formulations.

How can PubCompare.ai help researchers optimize their use of Sodium Carboxymethylcellulose?

PubCompare.ai is a powerful tool that can assist researchers in optimizing their use of Sodium Carboxymethylcellulose. The platform allows you to efficiently screen protocol literature and leverage AI to pinpoint critical insights. By using PubCompare.ai, you can identify the most effective protocols related to CMC for your specific research goals. The platform's AI-driven analysis can highlight key differences in protocol effectiveness, enabling you to choose the best option for reproducibility and accuracy. This can help you save time, reduce research costs, and improve the reliability of your CMC-based studies and formulations.

More about "Sodium Carboxymethylcellulose"

Sodium Carboxymethylcellulose, Carboxymethylcellulose sodium salt, DMSO, Sodium carboxymethyl cellulose (Na-CMC), CMC-Na, Carboxymethylcellulose sodium, Acetonitrile, FBS, Carboxymethylcellulose sodium salt (CMC)