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TMEDA

TMEDA, or N,N,N',N'-Tetramethylethylenediamine, is a versatile organic compound with diverse applications in chemistry and materials science.
It serves as a bidentate ligand, a coordinating agent, and a base in various organic reactions and synthetic procedures.
TMEDA plays a crucial role in the synthesis of organometallic compounds, the formation of stable metal complexes, and the deprotonation of acidic substrates.
Its ability to chelate metal ions makes it a valuable tool in organic transformations, metal-catalyzed reactions, and the preparation of novel materials.
Researchers can leverage PubCompare.ai's AI-powered platform to quickly identify the best TMEDA-related protocols from published literature, preprints, and patents, ensuring reproducibility and accuracy in their TMEDA-based research and optimizaiton efforts.

Most cited protocols related to «TMEDA»

Firstly, CNC suspension was prepared using the acid hydrolysis technique as previously reported [30 (link)]. In a brief explanation, 10 g of cotton pulp was dispersed in 64% of sulfuric acid (H2SO4) under constant magnetic stirring (300 rpm) at 60 °C over a period of 2 h. Later, the hydrolysis reaction was stopped through the addition of 10 times excess cold DI water, followed by successive centrifugation (30 min, 11,000 rpm), and finally, the suspension was dialyzed overnight to attain neutrality pH = 7. The 0.5 wt% of CNC suspension was prepared via re-dispersion of CNC in DI water, stored in a glass vial at 4 °C until use. Before hydrolysis, an alkaline (1 M NaOH) treatment was carried out to remove the noncellulosic components from the cotton pulp to improve the CNC quality.
The PAC hydrogels were prepared using the standard procedure reported previously [2 (link),10 (link)]. In brief, 1 wt% of (based on Am concentration) CNC was dispersed in 5 mL of DI water under constant magnetic stirring with 200 rpm. Then, 14.08 mM of Am was dissolved in this solution under the same stirring condition until Am was dissolved. To the solution, MBA and APS/TMEDA were added as per the specifications given in Table 1, and the mixture was stirred for another 30 min. The solution was poured into a petri dish and kept in an oven at 45 °C, where a hydrogel was formed. The formed hydrogel was transferred into a 250 mL beaker containing 100 mL of DI water in order to remove unreacted monomers, cross-linker, and pre-polymer from the hydrogel, and the water was repeatedly changed every 6 h up to 48 h [6 (link)]. Similarly, CNC varied (1, 3, and 5 wt. %) PAC hydrogels and the pristine polyacrylamide hydrogel were synthesized using the above procedure, and the developed hydrogels were named as PAm, PAC1, PAC2m and PAC3, respectively, as shown in Table 1. Figure 1 shows the schematics of PAC hydrogel formation.
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Publication 2019
Acids Centrifugation Cold Temperature Dental Pulp Gossypium Hydrogels Hydrolysis Hyperostosis, Diffuse Idiopathic Skeletal polyacrylamide hydrogels Polymers Sulfuric Acids TMEDA
The method for the preparation of LC Bead® (Biocompatibles UK Ltd., Farnham, UK) has been described in detail elsewhere 24 . Briefly, the beads were produced using a PVA-based macromer. The macromer was synthesized by the acid-catalyzed reaction of N-acryloyl-aminoacetaldehyde dimethylacetal (NAAADA) with the 1,3 diol units on the PVA backbone to form a stable cyclic acetal structures with pendent reactive acrylamide groups. The macromer was used in an inverse suspension free-radical copolymerization with 2-acrylamido-2-methylpropanesulfonate sodium salt (AMPS). The aqueous macromer/monomer mixture was suspended in butyl acetate and stabilised by cellulose acetate butyrate to prevent coagulation. Potassium persulfate was used as one half of a redox initiator couple, which is present in the aqueous phase. The stirred mixture was heated to 60°C and then tetramethylethylenediamine (TMEDA, the other component of the redox couple) was added to the oil phase, where upon polymerization was initiated and a water-swollen crosslinked network formed. After the polymerization was complete the beads were dried by washing in acetone and drying in an oven at 40°C overnight to form a free-flowing powder 24 . PVA-AMPS beads were originally developed from contact lens technology and are thus inherently optically transparent and biocompatible. These beads are tinted blue using a reactive dye (Reactive Blue 4, RB4) to enable visualization of the bead suspension to make for easier handling (Figure 1). A novel process was developed in which the blue tinting step was replaced by an alternative reaction to attach a radiopaque moiety (triiodonated benzyl) to the preformed hydrogel (Figure 1). In order to couple the radiopaque compound to the polymer backbone, the beads in dimethyl sulfoxide (DMSO) were reacted with 2,3,5-triiodobenzaldehyde in an acid-catalyzed reaction under nitrogen with stirring, to form stable cyclic acetal linkages with pendent triiodobenzyl moieties. Consumption of the aldehyde was monitored using high-performance liquid chromatography (HPLC) and once complete, the reaction was filtered. The cake of beads was washed thoroughly with copious amounts of DMSO and then water, until free of unreacted aldehyde as determined by HPLC.
Publication 2016
1,1-dimethoxyethane 2-acrylamido-2-methylpropanesulfonate Acetals Acetone Acids Acrylamide Aldehydes butyl acetate cellulose acetate-butyrate Coagulation, Blood Contact Lenses Free Radicals High-Performance Liquid Chromatographies Hydrogels Nitrogen Oxidation-Reduction Polymerization Polymers potassium persulfate Powder procion blue MX-R Radio-Opaque acrylic resin Salts Sodium Sulfoxide, Dimethyl tetramethylethylenediamine TMEDA Vertebral Column
PbS nanocrystals (0.5 g) were dissolved in d6-benzene (2 mL) and TMEDA (3 mL) was added. After stirring for 10 minutes, acetonitrile (5 mL) was added and the nanocrystals separated by centrifugation. The clear supernatant was collected and dried under vacuum for 5 hours. d6-benzene (0.6 ml) was added to dissolve the residue and the solution was analyzed with 1H NMR spectroscopy. Infrared absorption spectroscopy was performed using diffuse reflectance geometry as a mixture with KBr. Energy dispersive X-ray spectroscopy was conducted on a film drop-cast on a highly ordered pyrolitic graphite substrate using a Cold Field Emission Hitachi 4700 Scanning Electron Microscope. 1H NMR (C6D6, 500 MHz): δ = 0.91 (t, 6H, −CH3), 1.281.6 (b, 44H, −CH2), 1.84 (m, 4H, β-CH2), 1.94 (s, 4H, −NCH2), 2.09 (m, 8H, −C=CCH2), 2.24 (s, 12H, −N(CH3)2), 2.52 (t, 4H, α-CH2), 5.49 (m, 4H, −CH=CH), 9.3 (b, −NH). FT-IR (Diamond ATR): ν = 1384 cm−1 (s CO2 assym), 1560 cm−1 (s CO2 sym), 1720 cm−1 (w COOH), 2920 cm−1 (s C-H).
Publication 2013
1H NMR acetonitrile Benzene CD3EAP protein, human Centrifugation Cold Temperature Diamond Energy Dispersive X Ray Spectroscopy Graphite Scanning Electron Microscopy Spectroscopy, Nuclear Magnetic Resonance Spectrum Analysis TMEDA Vacuum
All manipulations were performed under inert conditions using either standard Schlenk techniques or nitrogen-filled glovebox. House nitrogen was purified through a MBraun HP-500-MO-OX gas purifier. nHexane, toluene and THF were purified by refluxing over potassium using benzophenone as an indicator and distilled prior to use. The chemicals pentamethylcyclopentadiene (Cp*H), allylmagnesium chloride (2.0 M in THF), potassium bistrimethylsilylamide (KN(Si(CH3)3)2), anhydrous YCl3, and 2.2.2-cryptand (crypt-222) were purchased from Sigma-Aldrich. 2.2.2-cryptand (crypt-222) was recrystallized from nhexane prior to use. KCp*,30 (link) (HNEt3)(BPh4),31 (link) Cp*2Y(BPh4),19 (link) H2Bbim,32 (link) (Li(TMEDA))2Bbim33 (link) and KC834 (link) were synthesized according to literature procedures.
Publication 2022
benzophenone CFC1 protein, human Chlorides cryptand Nitrogen Potassium TMEDA Toluene yttrium chloride
In a 100 mL two-neck round-bottom flask(3.84 g, 10 mmol) of compound 7 was swelled in 20 mL THF overnight, then (3.32 mL, 20 mmol) of CHIPA was added at −96 °C (using methanol and liquid nitrogen) as cooling bath, then (3 mL, 15 mmol) of n-BuLi was added drop wise then the reaction mixture was stirred for 1 h under N2-gas, then 1 mL of TMEDA was added as catalyst and finally (1.24 mL, 20 mmol) of methyl iodide was added drop wise at −40 °C, then the reaction mixture was stirred overnight. The resulting solid was filtered, washed with water, and dried [37 (link),38 ]. Yield: 90%; 1H NMR (400 MHz, DMSO-d6) δ (ppm): 7.05–8.22 (m, 13H, Ar-H), 0.98 (t, 3H, CH3), 1.20 (d, 3H, CH3), 1.60 (m, 2H, CH2), 2.55 (m, 1H, CH); 13C NMR (400 MHz, DMSO-d6) δ (ppm): 127.6, 133.5, 122.5, 151.5, 121, 128.8, 164, 161, 128.7, 129.8, 122, 121.9, 147, 175.5, 41, 16.5, 126, 129, 130, 26.5, 12; IR (KBr) ν: 1725 (CO), 3069 (Ar-H), 2989 (aliph-H); Anal. Calcd for C25H22N2O3 (398.45): C, 75.36%; H, 5.57%; O, 12.05%; N, 7.03%. Found: C, 75.13%; H, 5.37%; N, 6.92%.
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Publication 2020
1H NMR Anus Bath Carbon-13 Magnetic Resonance Spectroscopy Methanol methyl iodide n-butyllithium Neck Nitrogen Sulfoxide, Dimethyl TMEDA

Most recents protocols related to «TMEDA»

Example 2

To a graduated flask in a nitrogen atmosphere were added 3-dimethylaminopropyltrimethoxysilane and then anhydrous hexane to prepare a terminal modifier.

A sufficiently nitrogen-purged pressure-proof vessel was charged with n-hexane, butadiene, and TMEDA, followed by heating to 60° C. Next, butyllithium was added, and the mixture was then heated to 50° C. and stirred for three hours. Subsequently, the terminal modifier was added, and the mixture was stirred for 30 minutes. To the reaction solution were added methanol and 2,6-tert-butyl-p-cresol, and the resulting reaction solution was put into a stainless steel vessel containing methanol. Then, aggregates were collected. The aggregates were dried under reduced pressure for 24 hours to obtain a modified polybutadiene rubber (BR 1).

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Patent 2024
1,3-butadiene Atmosphere Blood Vessel butyllithium cresol Methanol n-hexane Nitrogen polybutadiene Pressure Rubber Stainless Steel TERT protein, human TMEDA
The synthesis of Pd-3 was similar to Pd-2: Ligand was first synthesized using the procedure according to the previously reported literature [10 (link)]. The solution of ligand (300 mg, 0.68 mmol) and (tmeda)PdMe2 (171.8 mg, 0.68 mmol) in 1.4-dioxane (30 mL) was stirred for 24 h at room temperature. The white powder produced during the reaction was filtered and dried in a vacuum. After added to 150 mL of DMSO, the mixture was stirred at 65 °C until the white solids were all dissolved. Subsequently, the solvent was further removed to give a beige solid, which was washed 3 times with ethyl ether and dried in vacuum (350 mg, 80.8% yield) (Figures S1–S3). 1H NMR (500 MHz, 298 K, CDCl3, 7.26 ppm): δ = 8.19 (dd, 1H, aryl-H), 7.42 (t, 1H, aryl-H), 7.28 (m, 2H, aryl-H), 6.09 (s, 2H, aryl-H), 3.82 (s, 6H, OCH3), 3.78 (s, 3H, OCH3), 3.06 (s, 6H, dmso-H), 2.84 (m, 1H, cyclohexane-H), 2.32 (m, 1H, cyclohexane-H), 1.89 (m, 1H, cyclohexane-H), 1.74 (m, 1H, cyclohexane-H), 1.68 (m, 2H, cyclohexane-H), 1.49 (m, 2H, cyclohexane-H), 1.25 (m, 3H, cyclohexane-H), 0.36 (s, 3H, Pd-CH3). 31P NMR (202 MHz, 298 K, CDCl3, 7.26 ppm): δ = 23.64. 13C{1H} NMR (125 MHz, 298 K, CDCl3, 77.16 ppm): δ = 164.55 (C-OCH3), 162.64 (C-OCH3), 148.08 (C-SO3), 132.88 (P-C(PhSO3)), 130.24, 130.11, 129.75, 128.33, 98.29 (P-C(PhOMe3)), 91.21, 55.64 (OCH3), 55.49 (OCH3), 41.33 (S-CH3), 40.28 (P-CH), 32.64 (CH2), 29.75 (CH2), 27.47 (CH2), 27.31 (CH2), 26.15 (CH2),−1.03 (Pd-CH3).
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Publication 2023
1H NMR Anabolism Carbon-13 Magnetic Resonance Spectroscopy Cyclohexane Dioxanes Ethyl Ether Ligands Powder Solvents Sulfoxide, Dimethyl TMEDA Vacuum
Determination of serum SOD activity was performed through the concept given by the scientists In which quercetin undergoes oxidation by O2.33 ,34 (link) Standard solutions were prepared by adding 0.8 mM tetramethylethylenediamine (TMEDA) and 0.08 mM EDTA together in a clean tube of buffer solution (pH = 9) containing 16 mM potassium sulfate. Then, 100 μL of serum and 20 μL of quercetin were added together, and after 20 minutes, the optical density was measured by a spectrophotometer at 406 nm.
Trace minerals (zinc and copper) were measured colorimetrically according to the manufacturer’s instructions (Randox, UK). The measurements of Vitamin C, catalase activity, GPx activity, and TAC were achieved after following the steps of the manufacturer (Elabscience, USA).
Publication 2023
Ascorbic Acid Buffers Catalase Copper Edetic Acid potassium sulfate Quercetin Randox Serum tetramethylethylenediamine TMEDA Trace Minerals Vision Zinc
Matrices were formed in a 1 mL syringe. A quantity of 0.8 mL of particle aqueous suspension containing 64 mg of PLA-MA and 16 mg of NCC-MA was prepared, and 0.15 mL of solution containing 216 mg of cross-linking agent (20 wt% from the total mass of reaction mixture, PEGDA or GelMA) was added to the particle suspension and homogenized with a thermoshaker (TS-100, Biosan, Riga, Latvia) at 500 rpm during 5 min. Then, solutions of 1.3 mg of initiator—ammonium peroxodisulfate (APS)—and 1.5 mg of reaction activator N,N,N′,N′-tetramethylethylenediamine (TMEDA) in 250 µL of ultrapure water were prepared. First APS and then TMEDA solutions were added under vigorous stirring to the precooled to 5 °C suspensions of particles with cross-linker. After that, the reaction mixture was immediately transferred into the syringe and placed in the freezer at −13 °C for 24 h. After this period, the samples were allowed to thaw, and the matrices were washed by passing a 100-fold of the volume of MQ water through them. Then, syringes were gently cut open to release the resulting matrix, which was further washed with MQ water over 48 h at 150 rpm stirring with thermoshaker.
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Publication 2023
Ammonium Biosan poly(ethylene glycol)diacrylate Syringes tetramethylethylenediamine TMEDA
Magnesium, turnings (Tokyo Chemical Industry Co., Ltd., Tokyo, Japan); 1,2-dibromoetane (>99.0%, Tokyo Chemical Industry Co., Ltd.); 2-bromo-3-hexylthiophene (>97.0%, Tokyo Chemical Industry Co., Ltd.); [1,3-bis(diphenylphosphino)propane]dichloronickel(II) (Ni(dppp)Cl2) (Sigma-Aldrich, St. Louis, MO, USA); 2-bromo-3-hexyl-5-iodothiophene (>97.0%, Tokyo Chemical Industry Co., Ltd.); isopropylmagnesium chloride–lithium chloride (i-PrMgCl·LiCl) (15% in tetrahydrofuran (THF), ca. 1 mol L−1, Tokyo Chemical Industry Co., Ltd.); boronic acid-functionalized resin (boronic acid, polymer-bound, 200–400 mesh, extent of labeling: 1.4–2.2 mmol/g loading, 1% cross-linked with divinylbenzene, Sigma-Aldrich); potassium carbonate (>80%, Wako Pure Chemical Industries, Ltd.) tetrakis(triphenylphosphine)palladium(0) (Pd(PPh3)4) (97.0%, Tokyo Chemical Industry Co., Ltd.); N,N,N’,N’-tetramethylethylenediamine (TMEDA) (>98.0%, Tokyo Chemical Industry Co., Ltd.); sec-butyllithium (sec-BuLi) (in cyclohexane, n-hexane, ca. 1 mol L−1, Kanto Chemical Co., Inc.); trimethyltin chloride (Me3SnCl) (>98.0%, Tokyo Chemical Industry Co., Ltd.); bis(benzonitrile)palladium(II) chloride (PdCl2(PhCN)2) (>95%, Sigma-Aldrich); triphenyl phosphine (PPh3) (>97.0%, Wako Pure Chemical Industries, Ltd.); chloroacetone (>95.0%, stabilized with magnesium oxide, Tokyo Chemical Industry Co., Ltd.); phosphoryl chloride (POCl3) (99.0%, Tokyo Chemical Industry Co., Ltd.); aminomethyl-functionalized resin (aminomethyl polystyrene resin cross-linked with 1% DVB (200–400 mesh) (2.0–3.0 mmol g−1)), 1,4-diazabicyclo[2.2.2]octane (DABCO) (>98.0%, Tokyo Chemical Industry Co., Ltd.); silver hexafluoroantimonate(V) (AgSbF6) (>97.0%, Tokyo Chemical Industry Co., Ltd.); 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) (98%, Angene Chemical, Nanjing, China); THF super dehydrated, stabilizer free (99.5%, Wako Pure Chemical Industries, Ltd., Osaka, Japan); n-hexane (>99.5%, Kanto Chemical Co. Ltd., Tokyo, Japan); acetone (>99.5%, Kanto Chemical Co. Ltd.); chloroform (CHCl3) (>99.0%, Kanto Chemical Co. Ltd.); methanol (MeOH) (>99.6%, Junsei Chemical Co. Ltd.); dichloromethane (CH2Cl2), specially prepared reagent for fluorometry (≥99.5%, NACALAI TESQUE, Co., Ltd., Kyoto, Japan); CDCl3 (99.8 atom%D, contains 0.5 wt.% silver foil as stabilizer, 0.03% (v/v) TMS, Sigma-Aldrich); dichloromethane-d2 (99.9 atom%D, Tokyo Chemical Industry Co., Ltd.) were used as received without purification. THF for cyclization (stabilizer free, water content <10 ppm, Kanto Chemical Co. Ltd.) and N,N-dimethylformamide (DMF), super dehydrated (99.5%, Kanto Chemical Co. Ltd.) were purified by a solvent purification system (MBRAUN MB-SPS-Compact). Toluene (>98.0%, Kanto Chemical Co. Ltd.) was distilled over Na. The polymerization experiments were carried out in an MBRAUN stainless steel glovebox equipped with a gas purification system (molecular sieves and copper catalyst) in a dry argon atmosphere (H2O, O2 <1 ppm). The moisture and oxygen contents in the glovebox were monitored by an MB-MO-SE 1 moisture sensor and an MB-OX-SE 1 oxygen sensor, respectively.
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Publication 2023
2-bromo-3-hexylthiophene Acetone Argon Atmosphere benzonitrile Boronic Acids butyllithium Chloride, Lithium Chlorides chloroacetone Chloroform Copper Cyclization Cyclohexane Dimethylformamide divinylbenzene Fluorometry Magnesium Methanol Methylene Chloride n-hexane octane Oxide, Magnesium Oxygen Palladium palladium chloride phosphoryl chloride Polymerization Polymers Polystyrenes potassium carbonate Propane Resins, Plant Silver Solvents Stainless Steel tetrahydrofuran tetramethylethylenediamine TMEDA Toluene triethylenediamine trimethyltin chloride triphenylphosphine

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Acrylic acid is a colorless, flammable liquid chemical compound with the formula CH2=CHCOOH. It is a carboxylic acid with a vinyl group. Acrylic acid is a widely used industrial chemical with applications in the production of various polymers and other chemical compounds.
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1-vinylimidazole is a chemical compound used as a laboratory reagent. It is a colorless liquid with a pungent odor. 1-vinylimidazole is used in various chemical synthesis and analysis applications, but its core function is not provided in order to maintain an unbiased and factual approach.
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N,N,N′,N′-tetramethyl ethylenediamine (TMEDA) is a colorless, volatile liquid chemical compound. It is used as a complexing agent and as a catalyst in various organic synthesis reactions.
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TMEDA is a chemical compound primarily used as a solvent and a chelating agent in organic synthesis. It is a colorless liquid with a characteristic amine-like odor. TMEDA's core function is to coordinate with and stabilize various metal ions, which can be useful in a range of chemical reactions and applications.
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Acrylate PEG is a polyethylene glycol (PEG) derivative containing acrylate functional groups. It is a versatile polymer that can be used in various biomedical and material science applications.
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Acrylate PEG-NH2 is a polyethylene glycol (PEG) derivative with an acrylate group and a primary amine group. It is a commonly used crosslinker and monomer in the synthesis of hydrogels and other polymeric materials.
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4-Imidazolecarboxylic acid is a chemical compound used in various applications, including as a research tool in scientific laboratories. It is a heterocyclic carboxylic acid containing an imidazole ring. The core function of this product is to serve as a building block or intermediate for the synthesis of other chemical compounds or materials.
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N-(3-aminopropyl)methacrylamide hydrochloride (APMA) is a chemical compound used in various laboratory applications. It is a monomer that can be polymerized to produce polymeric materials. The core function of APMA is to serve as a building block for the synthesis of specific polymers and materials for research and development purposes.
N,N'-bis(acryloyl)cystamine (BACA) is a chemical compound used in laboratory settings. It is a bifunctional monomer with two acryloyl groups and a central cystamine moiety. BACA is utilized in the synthesis and modification of polymeric materials, but its core function is not further extrapolated on.
Acrylate PEG-Mal (APEG-Mal) is a versatile laboratory reagent used in various applications. It is a polyethylene glycol (PEG) derivative with a terminal acrylate group and a maleimide group. The acrylate group allows for crosslinking reactions, while the maleimide group enables thiol-based conjugation.

More about "TMEDA"

N,N,N',N'-Tetramethylethylenediamine, commonly known as TMEDA, is a versatile organic compound with a wide range of applications in chemistry and materials science.
It serves as a bidentate ligand, a coordinating agent, and a base in various organic reactions and synthetic procedures.
TMEDA plays a crucial role in the synthesis of organometallic compounds, the formation of stable metal complexes, and the deprotonation of acidic substrates.
Its chelating ability makes it a valuable tool in organic transformations, metal-catalyzed reactions, and the preparation of novel materials.
Beyond TMEDA, related compounds like acrylic acid, 1-vinylimidazole, acrylate PEG, acrylate PEG-NH2, 4-imidazolecarboxylic acid, N-(3-aminopropyl)methacrylamide hydrochloride (APMA), and N,N'-bis(acryloyl)cystamine (BACA) also find applications in chemistry, materials science, and biomedical engineering.
These compounds can be used in combination with TMEDA to develop advanced materials, drug delivery systems, and functional polymers.
Reserachers can leverage PubCompare.ai's AI-powered platform to quickly identify the best TMEDA-related protocols from published literature, preprints, and patents, ensuring reproducibility and accuracy in their TMEDA-based research and optimization efforts.
The platform's AI comparisons help researchers locate the most effective protocols and products for their specific needs.