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Varenicline
Varenicline
Varenicline is a partial agonist of the α4β2 nicotinic acetylcholine receptor that is approved for the treatment of tobacco dependence.
It works by reducing cravings and withdrawal symptoms associated with smoking cessation.
Varenicline has been shown to be effective in helping people quit smoking and maintaining abstinence over the long term.
Researchers can use PubComapre.ai to easily locate relevant protocols from the literature, preprints, and patents, and leverage AI-driven comparisons to identify the best methods and products for their Varenicline research.
This can enhance the reproducibility and accuaracy of their findings.
It works by reducing cravings and withdrawal symptoms associated with smoking cessation.
Varenicline has been shown to be effective in helping people quit smoking and maintaining abstinence over the long term.
Researchers can use PubComapre.ai to easily locate relevant protocols from the literature, preprints, and patents, and leverage AI-driven comparisons to identify the best methods and products for their Varenicline research.
This can enhance the reproducibility and accuaracy of their findings.
Most cited protocols related to «Varenicline»
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Most recents protocols related to «Varenicline»
Example 7
LC-ESI-HRMS Method for the Determination of Varenicline Nitroso-Drug Substance Related Impurity, U.S. FDA, Aug. 6, 2021, www.fda.gov/media/151470/download (accessed Feb. 27, 2022) can be used to test for impurities.
Other analytical methods for the entire process can be used to test for impurities. The methods are validated as per ICH guideline.
For example, HPLC RS methods are used for quantifying the impurities. The nitrosamines, monomethyl and dimethyl tartaric acid esters are quantified by LCMS methods.
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Esters
High-Performance Liquid Chromatographies
Laser Capture Microdissection
Nitrosamines
Pharmaceutical Preparations
tartaric acid
Varenicline
Example 18
A solution of Varenicline free base (25.0 g) in methylene dichloride (125 mL) was stirred with the aqueous solution of succinic acid (16.77 g, 1.2 eq in 125 mL of water). The aqueous layer containing Varenicline succinate was stirred with methylene dichloride to remove the nitrosamine impurity by solvent extraction. Thereafter, follow the general procedure for the isolation of Varenicline base from the aqueous layer. Yield 15.6 g
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isolation
Methylene Chloride
Nitrosamines
Solvents
Succinates
Succinic Acid
Varenicline
Example 21
A solution of Varenicline free base (5.0 g) in methanol (50 mL) was stirred under hydrogen (6.0 kg/cm2) pressure in the presence of 10% Palladium on carbon (0.5 g, 50% wet) at 25-35° C. After 6 hours and the reaction mass was filtered through celite pad and rinsed with methanol (50 ml). The filtrate was distilled completely under reduced pressure and co-distilled with methyl tert-butyl ether to remove traces of methanol & water. methyl tert-butyl ether (50.0 mL, 10.0 volume) was added to the concentrated mass and stirred at 5-10° C. for 3 hours. The product was isolated by filtration and washed with chilled methyl tert-butyl ether by twice. The wet material was dried at 40° C. under vacuum. Yield: 4.2 g
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Carbon
Celite
Filtration
Hydrogen
Methanol
methyl tert-butyl ether
Palladium
Pressure
Vacuum
Varenicline
Example 19
A solution of Varenicline free base (20.0 g) in methylene dichloride (100 ml) was stirred with the aqueous solution of Oxalic acid (14.35 g, 1.2 eq in 100 ml of water). The aqueous layer containing Varenicline oxalate was stirred with methylene dichloride to remove the nitrosamine impurity by solvent extraction. Thereafter, follow the general procedure for the isolation of Varenicline base from the aqueous layer. Yield: 14.6 g.
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isolation
Methylene Chloride
Nitrosamines
Oxalates
Oxalic Acid
Solvents
Varenicline
Example 22
Varenicline free base (7 g) was dissolved in methanol (140 ml) at 25-30° C. In a separate flask, tartaric acid (4.92 g) was dissolved in 70 ml water at 25-30° C. Varenicline solution was mixed with tartaric acid solution at 25-35° C. The resulting clear solution was stirred for 30 min at 25-35° C. to form the Varenicline tartrate salt solution. Maltodextrin (119.84 g) was dissolved in water (420.53 ml) at 25-35° C. separately and added this Maltodextrin solution into Varenicline tartrate solution prepared earlier. The resulting clear solution was stirred for 30 minutes, filtered through a micron filter and washed with water (2×70 ml). The clear filtrate was subjected to spray drying using a spray dryer to obtain the amorphous Varenicline Tartrate Maltodextrin Premix (1:10) API. Yield: 130.0 g. Purity by HPLC: 99.99%.
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High-Performance Liquid Chromatographies
maltodextrin
Methanol
Sodium Chloride
tartaric acid
Varenicline
Varenicline Tartrate
Top products related to «Varenicline»
Sourced in United States
Varenicline is a laboratory product manufactured by Pfizer. It is a small molecule used in research applications.
Sourced in United States, Canada, Sao Tome and Principe
Nicotine hydrogen tartrate salt is a chemical compound that is used as a laboratory reagent. It is a crystalline solid and is soluble in water and various organic solvents. The compound is commonly used in scientific research and development applications.
Sourced in United States, Sao Tome and Principe, United Kingdom
Nicotine hydrogen tartrate is a chemical compound used in various laboratory applications. It serves as a precursor for the synthesis of nicotine and other related compounds. The compound is a white, crystalline powder with a characteristic odor. It is soluble in water and certain organic solvents. Nicotine hydrogen tartrate is primarily utilized in research and development settings to facilitate the study and production of nicotine-based products.
Sourced in Macao, Australia
Varenicline is a laboratory equipment product manufactured by Merck Group. It is a chemical compound used as a research tool in scientific investigations. The core function of Varenicline is to serve as a tool for researchers and scientists in their studies and experiments, without further interpretation or extrapolation on its intended use.
Sourced in United States, Germany, China, Sao Tome and Principe
Cocaine hydrochloride is a chemical compound that is used in various laboratory settings. It is a crystalline powder that is soluble in water and has a bitter taste. The core function of cocaine hydrochloride is as a local anesthetic and a stimulant. It is used in research and analysis applications.
Sourced in United Kingdom
Varenicline is a laboratory reagent produced by Bio-Techne. It is a chemical compound used in research applications. The core function of Varenicline is to serve as a research tool without interpretation of its intended use.
Sourced in United States
Epibatidine dihydrochloride hydrate is a chemical compound used in laboratory research. It is a nicotinic acetylcholine receptor agonist. The core function of this product is to serve as a research tool for investigating nicotinic receptor activity and related biological processes.
Sourced in United States
Varenicline tartrate is a chemical compound used in the production of pharmaceutical products. It is a key ingredient in certain medication formulations. The core function of varenicline tartrate is to serve as an active pharmaceutical ingredient in the manufacturing process. No further details on intended use or application can be provided in an unbiased and factual manner.
Sourced in United States, United Kingdom, Germany, Japan
Mecamylamine is a chemical compound that functions as a nicotinic acetylcholine receptor antagonist. It is a laboratory product used in various research applications.
Sourced in United States
Nicotine tartrate is a chemical compound commonly used as a laboratory reagent. It is a salt formed by the combination of nicotine and tartaric acid. This product is typically used in research and analysis applications, but its specific intended use should not be extrapolated or interpreted.
More about "Varenicline"
Varenicline, a partial agonist of the α4β2 nicotinic acetylcholine receptor, is a widely recognized and approved medication for the treatment of tobacco dependence.
It works by reducing cravings and withdrawal symptoms associated with smoking cessation, making it an effective tool in helping people quit smoking and maintain abstinence over the long term.
Researchers can leverage PubCompare.ai to easily locate relevant protocols from the literature, preprints, and patents, and utilize AI-driven comparisons to identify the best methods and products for their Varenicline research.
This can enhance the reproducibility and accuracy of their findings, leading to more robust and reliable results.
Other related terms and compounds that may be relevant for Varenicline research include Nicotine hydrogen tartrate salt, Nicotine hydrogen tartrate, Cocaine hydrochloride, Epibatidine dihydrochloride hydrate, Varenicline tartrate, Mecamylamine, and Nicotine tartrate.
Exploring the properties, interactions, and applications of these substances can provide valuable insights and context for Varenicline-related studies.
By leveraging the power of PubCompare.ai and incorporating a comprehensive understanding of Varenicline and related compounds, researchers can optimize their research processes, enhance the quality of their findings, and ultimately contribute to the advancement of smoking cessation and addiction treatment strategies.
It works by reducing cravings and withdrawal symptoms associated with smoking cessation, making it an effective tool in helping people quit smoking and maintain abstinence over the long term.
Researchers can leverage PubCompare.ai to easily locate relevant protocols from the literature, preprints, and patents, and utilize AI-driven comparisons to identify the best methods and products for their Varenicline research.
This can enhance the reproducibility and accuracy of their findings, leading to more robust and reliable results.
Other related terms and compounds that may be relevant for Varenicline research include Nicotine hydrogen tartrate salt, Nicotine hydrogen tartrate, Cocaine hydrochloride, Epibatidine dihydrochloride hydrate, Varenicline tartrate, Mecamylamine, and Nicotine tartrate.
Exploring the properties, interactions, and applications of these substances can provide valuable insights and context for Varenicline-related studies.
By leveraging the power of PubCompare.ai and incorporating a comprehensive understanding of Varenicline and related compounds, researchers can optimize their research processes, enhance the quality of their findings, and ultimately contribute to the advancement of smoking cessation and addiction treatment strategies.