In addition to the UT Lung SPORE data, 7 public NSCLC microarray datasets (10 (link), 13 , 17 (link), 26 (link)–29 (link)) were used in this study. The National Cancer Institute Director’s Challenge Consortium study (Consortium dataset)(13 ), which is the largest independent public available lung cancer microarray dataset and involves 442 resected ADCs, was used as the training set. Six datasets were used to validate the prognosis signature: UT lung SPORE data, GSE3141 (ADC n=58, SCC n=53), GSE8894 (ADC n=62, SCC n=76), GSE11969 (ADC n=90, and SCC n=35), GSE13213 (ADC n=117), GSE4573 (SCC n=129). Among these 6 datasets, three (GSE 13213, GSE8894 and GSE11969) are Asian cohorts. Two datasets were used to validate the predictive signature: UT lung SPORE data and GSE14814 that includes 90 samples (49 patients with vinorelbine plus cisplatin ACT and 41 patients without ACT) collected from the JBR.10 trial. Table 1 provides detailed information on these datasets. Since 43 out of 133 samples in the original JBR.10 dataset (GSE14814) were also included in the Consortium data (training set), these 43 samples were excluded from the JBR.10 dataset to ensure the independence between the training and validation sets.
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Vinorelbine
Vinorelbine
Vinorelbine is a semi-synthetic vinca alkaloid derived from the periwinkle plant.
It is a microtubule-disrupting agent used as an antineoplastic drug for the treatment of various cancers, including non-small cell lung cancer, breast cancer, and advanced ovarian cancer.
Vinorelbine works by interfering with the assembly of microtubules, leading to cell cycle arrest and apoptosis in rapidly dividing cancer cells.
It is typically administed intravenously or orally and has a well-established safety profile.
Resesarch on optimizing Vinorelbine protocols can help improve reproducibility and efficacy in clinical settings.
It is a microtubule-disrupting agent used as an antineoplastic drug for the treatment of various cancers, including non-small cell lung cancer, breast cancer, and advanced ovarian cancer.
Vinorelbine works by interfering with the assembly of microtubules, leading to cell cycle arrest and apoptosis in rapidly dividing cancer cells.
It is typically administed intravenously or orally and has a well-established safety profile.
Resesarch on optimizing Vinorelbine protocols can help improve reproducibility and efficacy in clinical settings.
Most cited protocols related to «Vinorelbine»
Asian Persons
Cisplatin
Lung
Lung Cancer
Microarray Analysis
Non-Small Cell Lung Carcinoma
Patients
Prognosis
Spores
Vinorelbine
The following chemotherapies were used in these studies: 5-fluorouracil (5-FU), bleomycin, cisplatin, cyclophosphamide (CY), docetaxel, doxorubicin, etoposide phosphate, gemcitabine, irinotecan, vinorelbine and were obtained from the pharmacy department at Sir Charles Gardiner Hospital, Perth, Australia. Further details are available in Additional file 1 : Table S1. All mice were dosed intraperitoneally (i.p) using a 29G insulin syringe. Chemotherapy was prepared and diluted under sterile conditions in either phosphate buffered saline (PBS) or 0.9% sodium chloride as per manufacturer’s instructions. Where possible, chemotherapy was made to a dilution whereby a 20 g mouse would receive a 100 μl i.p injection.
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Bleomycin
Cisplatin
Cyclophosphamide
Docetaxel
Doxorubicin
etoposide phosphate
Gemcitabine
Insulin
Irinotecan
Mice, House
Pharmacotherapy
Phosphates
Saline Solution
Sterility, Reproductive
Syringes
Technique, Dilution
Vinorelbine
Drug screening data were downloaded from Genomics of Drug Sensitivity in Cancer (GDSC) Project (https://www.cancerrxgene.org/downloads/bulk_download , accessed on 15 April 2021) [53 (link)]. The GDSC Project screened more than 1,000 genetically characterized human cancer cell lines with a wide range of anti-cancer therapeutic agents. Among the commonly used chemotherapeutic regimens in treating NSCLC drugs, nine were found in GDSC1, including cisplatin, docetaxel, erlotinib, etoposide, gefitinib, gemcitabine, pemetrexed, and vinorelbine; seven were found in GDSC2, including cisplatin, docetaxel, erlotinib, gefitinib, gemcitabine, paclitaxel, and vinorelbine. For each drug, cell lines were defined as resistant, sensitive, or partial response by using the mean ± 0.5 SD of the IC50 values as described above.
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Antineoplastic Agents
Cell Lines
Cisplatin
Dietary Fiber
Docetaxel
Erlotinib
Etoposide
Gefitinib
Gemcitabine
Homo sapiens
Hypersensitivity
Malignant Neoplasms
Non-Small Cell Lung Carcinoma
Paclitaxel
Pharmaceutical Preparations
Pharmacotherapy
Therapeutics
Treatment Protocols
Vinorelbine
The growth inhibitory activity of 4518 drugs was quantified in 578 human cancer cell lines using the PRISM molecular barcoding and multiplexed screening method [66 (link)]. The PRISM repurposing dataset is available at the Cancer Dependency Map portal (https://depmap.org/portal/download/ , accessed on 1 April 2021). Drug responses of nine commonly used chemotherapeutic regimens in treating NSCLC were included in this study: carboplatin, cisplatin, paclitaxel, docetaxel, gemcitabine, vinorelbine, etoposide, gefitinib, and erlotinib. For each drug, cell lines were defined as resistant, sensitive, or partial response by using the mean ± 0.5 standard deviation (SD) of the IC50 or EC50 values [67 (link),68 (link)]. Cell lines with an IC50 or EC50 value greater than the mean + 0.5 SD were defined as resistant to the drug. Cell lines with an IC50 or EC50 value less than the mean − 0.5 SD were defined as sensitive to the drug, and those with an IC50 or EC50 value between the mean + 0.5 SD and the mean − 0.5 SD were defined as having a partial response to the drug. This categorization corresponds to the RECIST 1.1 system (i.e., complete response, partial response, and stable disease/disease progression) in evaluating chemotherapeutic response in solid tumors [69 (link)].
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Carboplatin
Cell Lines
Cisplatin
Disease Progression
Docetaxel
Erlotinib
Etoposide
Gefitinib
Gemcitabine
Homo sapiens
Malignant Neoplasms
Neoplasms
Non-Small Cell Lung Carcinoma
Paclitaxel
Pharmaceutical Preparations
Pharmacotherapy
prisma
Psychological Inhibition
Treatment Protocols
Vinorelbine
After induction chemotherapy, all patients received dose‐differentiated accelerated radiotherapy with intensity modulated radiotherapy (IMRT‐DART). The details of this treatment approach were described elsewhere.6 In brief, the cornerstones of this regimen are the sequential chemoradiation mode, the dose increments from 73.8 to 90 Gy depending on tumor size and twice daily treatment with 1.8 Gy per fraction. In the current study, however, the former conventional 3D‐target splitting technique was replaced by IMRT. As of 2017, ultracentrally located tumors with invasion of the central vessels or airways in pretreatment contrast enhanced thoracic CT scan were treated ‐ regardless of size ‐ with a total dose of 61.2 or 73.8 Gy in order to reduce the risk of lethal hemorrhage due to rapid tumor regression.24 Involved lymph nodes received 54–61.2 Gy in twice daily fractions of 1.8 Gy each. The nodes next to the involved area were treated with 1.4 Gy bid to a total dose of 47.6 Gy. As for dose constraints, the following limits were applied24 , 25 , 26 , 27 , 28 : mean lung dose (MLD) < 20 Gy, V25total lung < 30%, V20ipsilateral lung < 50%, mean esophageal dose (MED) < 34 Gy, maximum dose to the spinal cord 45 Gy (maximum dose of 1.3 Gy per fraction), V25heart < 10%. In order to mitigate potential esophageal toxicity, all patients received local antimycotic prophylaxis.29 Radiotherapy planning was performed when patients received the second cycle of systemic treatment. Induction chemotherapy consisted of two cycles of either Cisplatinum or Carboplatinum combined with Pemetrexed, Gemcitabine or Vinorelbine according to histology. As of September 2017, patients received Durvalumab maintenance therapy for one year after the end of radiotherapy.5 , 30
Carboplatin
Chemoradiotherapy
Cisplatin
durvalumab
Gemcitabine
Hemorrhage
Induction Chemotherapy
Lung
Neoplasms
Neoplasms, Vascular Tissue
Nodes, Lymph
Patients
Radiotherapy
Radiotherapy, Intensity-Modulated
Spinal Cord
Therapeutics
Treatment Protocols
Vinorelbine
X-Ray Computed Tomography
Most recents protocols related to «Vinorelbine»
We retrospectively enrolled 278 patients diagnosed with advanced NSCLC who regularly received DP (docetaxel plus cisplatin), GP (gemcitabine plus cisplatin), NP (vinorelbine plus cisplatin), PC (pemetrexed plus cisplatin) and TP (paclitaxel plus cisplatin) chemotherapy regimens at the Affiliated Hospital of Xu Zhou Medical University from January May 2012 and July 2020.
The inclusion criteria were as follows: (1) NSCLC was pathologically diagnosed; (2) NSCLC was stage III or IV according to the American Joint Committee on Cancer (AJCC) 8th edition; (3) the patient received chemotherapy for more than two cycles without a combination of targeted therapy, radiation therapy and immune therapy; (4) the patient had no other cancer history and laboratory test results were obtained before treatment.
The exclusion criteria were as follows: (1) patients with missing or incomplete data; (2) patients who underwent surgery, radiotherapy, immunotherapy before standard chemotherapy protocols, (3) patients who had obvious fever and pneumonia before chemotherapy.
This retrospective study was approved by the ethics committee of the Affiliated Hospital of Xu Zhou Medical University.
The inclusion criteria were as follows: (1) NSCLC was pathologically diagnosed; (2) NSCLC was stage III or IV according to the American Joint Committee on Cancer (AJCC) 8th edition; (3) the patient received chemotherapy for more than two cycles without a combination of targeted therapy, radiation therapy and immune therapy; (4) the patient had no other cancer history and laboratory test results were obtained before treatment.
The exclusion criteria were as follows: (1) patients with missing or incomplete data; (2) patients who underwent surgery, radiotherapy, immunotherapy before standard chemotherapy protocols, (3) patients who had obvious fever and pneumonia before chemotherapy.
This retrospective study was approved by the ethics committee of the Affiliated Hospital of Xu Zhou Medical University.
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Antineoplastic Chemotherapy Protocols
Cisplatin
Combined Modality Therapy
Docetaxel
Ethics Committees, Clinical
Fever
Gemcitabine
Immunotherapy
Joints
Malignant Neoplasms
Non-Small Cell Lung Carcinoma
Operative Surgical Procedures
Patients
Pharmacotherapy
Pneumonia
Radiotherapy
TP protocol
Treatment Protocols
Vinorelbine
To examine the similarities between patients' diverse metabolic subtypes and the GSE91061 dataset (melanoma dataset undergoing anti-CTLA-4 and anti-PD-1 therapy), we used a subclass mapping technique. When the p value is decreased, the degree of similarity increases. At the same time, we compared the degree of responsiveness between various subtypes and conventional chemotherapeutic agents (cisplatin, vinorelbine, embellin, and pyrimethamine) using the same methodology.
We employed linear discriminant analysis, also abbreviated as LDA, to create a subtype classification feature index so that we could more accurately measure the immunological features of patients who were represented by a variety of sample cohorts. In the TCGA dataset, we employed the LDA model to compute each patient's subtype feature index, and we examined the feature index of each of the distinct subtypes. Within the TCGA dataset, we assessed the characteristics that were linked to prognosis. Firstly, a z-score was done on each individual feature, and Fisher's LDA optimization standard was utilized to specify that the centroids of each group should be as dispersed as possible. It was discovered that a linear combination A maximized the between-class variance of A in comparison to the variance of the within-class measure. The properties of the model allow for the differentiation between samples of various subtypes analyzed.
We employed linear discriminant analysis, also abbreviated as LDA, to create a subtype classification feature index so that we could more accurately measure the immunological features of patients who were represented by a variety of sample cohorts. In the TCGA dataset, we employed the LDA model to compute each patient's subtype feature index, and we examined the feature index of each of the distinct subtypes. Within the TCGA dataset, we assessed the characteristics that were linked to prognosis. Firstly, a z-score was done on each individual feature, and Fisher's LDA optimization standard was utilized to specify that the centroids of each group should be as dispersed as possible. It was discovered that a linear combination A maximized the between-class variance of A in comparison to the variance of the within-class measure. The properties of the model allow for the differentiation between samples of various subtypes analyzed.
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Antineoplastic Agents
Cisplatin
CTLA4 protein, human
Melanoma
Patients
Prognosis
Pyrimethamine
Therapeutics
Vinorelbine
The three-dimensional structures of six phytochemicals from Breastin (adynerin, neritaloside, oleandrin, vanderoside, odoroside A, and odoroside H) were downloaded from PubChem (http://www.PubChem.nih.gov ; accessed on 30 August 2022). The crystal structure of tubulin (PDB ID: 5N5N) was obtained from the Protein Data Bank (http://www.rcsb.org/ ; accessed on 30 August 2022). AutoDockTools 1.5.6 was used to convert all six compounds, tubulin microtubule inhibitors (vinorelbine, paclitaxel, and colchicine), and tubulin to Protein Data Bank Partial Charge and Atom Type (PDBQT) format. Four different grid boxes were prepared around the whole tubulin protein, the Vinca alkaloid-binding site, the taxol-binding site, and the colchicine-binding site to study the tubulin-binding behavior of Breastin compounds in silico. In AutoDock4.2.6. software, Lamarckian Algorithm was set with 10 runs and 2,500,000 energy evaluations to generate the docking log file. Binding energy and predicted Ki were collected from the RMSD cluster analysis while the interacting amino acids were identified with AutoDockTools [95 (link)]. Discovery Studio Visualizer software was used to create the visualizations of protein–ligand interactions.
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Amino Acids
Binding Sites
Colchicine
Ligands
Microtubules
neritaloside
odoroside
oleandrin
Paclitaxel
Phytochemicals
Proteins
Taxol
Tubulin
Tubulin Inhibitors
Vinca Alkaloids
Vinorelbine
The metronomic chemo-endocrine therapy FulVEC consisted of fulvestrant 500 mg i.m. administered on days 1, 14, 28, and q1m thereof combined with metronomic, continuous polychemotherapy VEC (vinorelbine 40 mg three times a week, cyclophosphamide 50 mg p.o. qd, capecitabine 500 mg p.o. tid). Dose adjustments were performed based on the evaluation of treatment-emergent adverse events, and particular drug-related AE has led to a stepwise reduction in a given drug. Upon the occurrence of vinorelbine-induced AE, the dosage was reduced from 50 mg tiw to 30 mg q2d. Capecitabine-related AE led to a stepwise reduction from 500 mg tid to 500 mg bid and then to 500 mg qd. The single-step reduction in cyclophosphamide was based on decreased frequencies from 50 mg qd to 50 mg q2d. In the case of non-sufficient dose reduction, the treatment with a particular drug was withheld until the resolution of particular AEs.
Data on the following background characteristics of the patients were collected using standardized data collection instruments: age; ECOG performance status; clinical symptoms; serum tumor markers, including CA-15.3; tumor stage (locally advanced or metastatic); sites of distant metastases; pathological diagnosis including immunohistochemistry.
Data on the following background characteristics of the patients were collected using standardized data collection instruments: age; ECOG performance status; clinical symptoms; serum tumor markers, including CA-15.3; tumor stage (locally advanced or metastatic); sites of distant metastases; pathological diagnosis including immunohistochemistry.
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Capecitabine
Combination Drug Therapy
Cyclophosphamide
Diagnosis
Drug Tapering
Electrocorticography
Fulvestrant
Immunohistochemistry
MUC1 protein, human
Neoplasm Metastasis
Neoplasms
Patients
Pharmaceutical Preparations
Serum
System, Endocrine
Tumor Markers
Vinorelbine
The retrospective, uni-institutional, observational study as a PhD project was planned for identification of all possible prognostic and predictive factors in locally advanced NSCLC patients treated by radical chemoradiotherapy. The presented study included patients who underwent sequential chemoradiotherapy in the years 2009–2014 in the largest Polish oncology center. Data of long-term clinical observation were used in the analysis of predictors for progression-free and overall survival (PFS, OS).
Inclusion criteria for sequential rather than concurrent chemoradiotherapy were defined according to local guidelines of National Research Institute of Oncology in Warsaw. Each patient had to have at least one of the following characteristics: (A) older age, which was confirmed as a favorable choice for this group of patients [1 (link)], (B) significant comorbidities, and/or (C) reduced exercise capacity defined below 100 by the Karnofsky Performance Scale (KPS).
Assessment of KPS was mandatory, at least at the start of treatment before chemotherapy and at the end of radiotherapy. KPS deterioration was understood as a decrease of at least 10 points between the first and last assessment.
Radiosensitizing chemotherapy had to be used before radiotherapy; there was a possible choice between (1) cisplatine-based regimen (PN: cisplatin + vinorelbine or PG: cisplatin + gemcitabine or PE cisplatin + etoposide) and (2) carboplatin-based regimen (carboplatin + vinorelbine or carboplatin + paclitaxel). The administered doses of radiation therapy were in the range of 5880 cGy to 6600 cGy.
The toxicity of chemotherapy and radiotherapy was recognized in accordance with the Common Terminology Criteria for Adverse Events (CTCAE).
The primary observation point was overall survival (OS). This was the time from the start of chemotherapy to the moment of death from any cause. The secondary endpoint was progression-free survival (PFS), which was measured from the date of the initiation of chemotherapy to the date of disease progression or death (if no progression was previously observed). The Kaplan–Meier estimator and Cox proportional hazard analysis were used for the evaluation of relationships between baseline KPS and the deterioration of KPS with OS and PFS. The odds ratio was used to assess risk factors for the occurrence of KPS deterioration during chemoradiotherapy.
Inclusion criteria for sequential rather than concurrent chemoradiotherapy were defined according to local guidelines of National Research Institute of Oncology in Warsaw. Each patient had to have at least one of the following characteristics: (A) older age, which was confirmed as a favorable choice for this group of patients [1 (link)], (B) significant comorbidities, and/or (C) reduced exercise capacity defined below 100 by the Karnofsky Performance Scale (KPS).
Assessment of KPS was mandatory, at least at the start of treatment before chemotherapy and at the end of radiotherapy. KPS deterioration was understood as a decrease of at least 10 points between the first and last assessment.
Radiosensitizing chemotherapy had to be used before radiotherapy; there was a possible choice between (1) cisplatine-based regimen (PN: cisplatin + vinorelbine or PG: cisplatin + gemcitabine or PE cisplatin + etoposide) and (2) carboplatin-based regimen (carboplatin + vinorelbine or carboplatin + paclitaxel). The administered doses of radiation therapy were in the range of 5880 cGy to 6600 cGy.
The toxicity of chemotherapy and radiotherapy was recognized in accordance with the Common Terminology Criteria for Adverse Events (CTCAE).
The primary observation point was overall survival (OS). This was the time from the start of chemotherapy to the moment of death from any cause. The secondary endpoint was progression-free survival (PFS), which was measured from the date of the initiation of chemotherapy to the date of disease progression or death (if no progression was previously observed). The Kaplan–Meier estimator and Cox proportional hazard analysis were used for the evaluation of relationships between baseline KPS and the deterioration of KPS with OS and PFS. The odds ratio was used to assess risk factors for the occurrence of KPS deterioration during chemoradiotherapy.
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Carboplatin
Chemoradiotherapy
Cisplatin
Concurrent Chemoradiotherapy
Disease Progression
Gemcitabine
Involuntary Treatment
Neoplasms
Non-Small Cell Lung Carcinoma
Paclitaxel
Patients
Pharmacotherapy
Radiotherapy
Treatment Protocols
Vinorelbine
VP-P protocol
Top products related to «Vinorelbine»
Sourced in United States
Vinorelbine is a prescription medication used as a chemotherapeutic agent. It is a vinca alkaloid that functions as a mitotic inhibitor, disrupting the formation of microtubules during cell division.
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Paclitaxel is a pharmaceutical compound used in the production of various cancer treatment medications. It functions as a microtubule-stabilizing agent, which plays a crucial role in the development and regulation of cells. Paclitaxel is a key ingredient in the manufacture of certain anti-cancer drugs.
Sourced in Germany
Vinorelbine is a chemotherapy agent used in the treatment of various types of cancer. It is a semi-synthetic vinca alkaloid that functions as a mitotic inhibitor, disrupting the process of cell division. The core function of Vinorelbine is to prevent the growth and spread of cancer cells.
Sourced in United States, Germany, China, United Kingdom, Italy, Japan, Canada
Docetaxel is a synthetic compound used in various laboratory applications. It is a member of the taxane class of antineoplastic agents. Docetaxel functions by disrupting the normal operation of cellular microtubules, which are essential for cell division and proliferation.
Sourced in United States, Germany, China
Docetaxel is a cytotoxic agent used in the production of various pharmaceutical formulations. It functions as a microtubule-stabilizing agent, which can inhibit cell division and proliferation. Docetaxel is commonly used as a reference standard in analytical methods for the identification and quantification of this compound.
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Cisplatin is a platinum-based medication used as a chemotherapeutic agent. It is a crystalline solid that can be dissolved in water or saline solution for administration. Cisplatin functions by interfering with DNA replication, leading to cell death in rapidly dividing cells.
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Etoposide is a chemotherapeutic agent used in the treatment of various types of cancer. It is a topoisomerase inhibitor that disrupts the process of DNA replication, leading to cell death. Etoposide is available as a solution for intravenous administration.
Sourced in Japan, United States
Eribulin is a synthetic analog of the natural product halichondrin B. It is a microtubule dynamics inhibitor that acts by binding to the plus end of microtubules, preventing their assembly and leading to cell cycle arrest and apoptosis.
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Gemcitabine is a nucleoside analog used as a laboratory reagent. It functions as an antimetabolite, inhibiting DNA synthesis.
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Cisplatin is a laboratory reagent used in various chemical and biochemical applications. It is a platinum-based compound with a formula of Pt(NH3)2Cl2. Cisplatin is widely used in scientific research, particularly in the fields of chemistry and biology.
More about "Vinorelbine"
Vinorelbine is a semi-synthetic vinca alkaloid derived from the periwinkle plant (Catharanthus roseus).
It is a microtubule-disrupting agent used as an antineoplastic drug for the treatment of various cancers, including non-small cell lung cancer (NSCLC), breast cancer, and advanced ovarian cancer.
Vinorelbine works by interfering with the assembly of microtubules, leading to cell cycle arrest and apoptosis in rapidly dividing cancer cells.
Vinorelbine is typically administered intravenously or orally and has a well-established safety profile.
It is often used in combination with other chemotherapeutic agents, such as Paclitaxel, Docetaxel, Cisplatin, Etoposide, Eribulin, or Gemcitabine, to enhance its efficacy in treating cancer.
Optimizing Vinorelbine protocols is crucial for improving reproducibility and efficacy in clinical settings.
PubCompare.ai, an AI-driven protocol comparison tool, can help researchers effortlessly locate and compare the best Vinorelbine protocols from literature, pre-prints, and patents.
This allows for the identification of the ideal protocol for your research needs, ultimately enhancing the impact of your Vinorelbine study.
The use of Vinorelbine in cancer treatment has been extensively studied, and researchers continue to explore ways to optimize its application and effectiveness.
By leveraging the power of AI-driven analysis, you can take your Vinorelbine research to new heights and contribute to the advancement of cancer treatment.
It is a microtubule-disrupting agent used as an antineoplastic drug for the treatment of various cancers, including non-small cell lung cancer (NSCLC), breast cancer, and advanced ovarian cancer.
Vinorelbine works by interfering with the assembly of microtubules, leading to cell cycle arrest and apoptosis in rapidly dividing cancer cells.
Vinorelbine is typically administered intravenously or orally and has a well-established safety profile.
It is often used in combination with other chemotherapeutic agents, such as Paclitaxel, Docetaxel, Cisplatin, Etoposide, Eribulin, or Gemcitabine, to enhance its efficacy in treating cancer.
Optimizing Vinorelbine protocols is crucial for improving reproducibility and efficacy in clinical settings.
PubCompare.ai, an AI-driven protocol comparison tool, can help researchers effortlessly locate and compare the best Vinorelbine protocols from literature, pre-prints, and patents.
This allows for the identification of the ideal protocol for your research needs, ultimately enhancing the impact of your Vinorelbine study.
The use of Vinorelbine in cancer treatment has been extensively studied, and researchers continue to explore ways to optimize its application and effectiveness.
By leveraging the power of AI-driven analysis, you can take your Vinorelbine research to new heights and contribute to the advancement of cancer treatment.