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Zolazepam

Zolazepam: A potent anxiolytic and sedative drug used to treat anxiety disorders and insomnia.
Zolazepam enhances the activity of the inhibitory neurotransmitter GABA in the brain, leading to a calming effect.
Researchers can utilize PubCompare.ai's AI-driven protocol comparison tool to optimize their Zolazepam studies, improving reproducibility and accuracy by identifying the best research protocols and products from the literature, pre-printes, and patents.
This powerful workflow streamliner helps deliver reliable results for Zolazepam research.

Most cited protocols related to «Zolazepam»

1
In Vivo Porcine Anesthesia and Euthanasia Protocol
Cited 11 times
All experiments were performed in vivo. Ethical approval
was obtained from The University of Auckland Animal Ethics Committee and the
International Guiding Principles for Biomedical Research Involving Animals were
followed. Sixteen white cross-breed weaner pigs were employed, of either sex and
of mean weight 36.7 ± 0.5 kg. The pigs were fasted then subjected to
general anesthesia that was induced with Zoletil (Tiletamine HCl 50 mg
mL−1 and Zolazepam HCl 50 mg mL−1),
and maintained with Isoflurane (2.5–5% with an oxygen flow of
400 mL within a closed circuit anesthetic system). A possible alternative
regimen of remifentanil/propofol has been found to be associated with pyloric
spasm in pigs and therefore was not considered.6 (link)A femoral artery was cannulated and vital signs were continuously
monitored including heart rate and blood pressure. Rectal and intra-abdominal
temperatures were also monitored, and these were kept in the normal
physiological range (38.5–39.5 °C) by continuous use of a
heating pad and the additional use of a heat lamp when necessary. A midline or
bilateral subcostal laparotomy was performed depending on the gastric region of
experimental interest, the latter incision being more suitable for
investigations of the proximal stomach. At the conclusion of the experiments,
the animals were euthanized with a bolus injection of 50 mL of magnesium sulfate
while still under anesthesia.
Egbuji J.U., O’Grady G., Du P., Cheng L.K., Lammers W.J., Windsor J.A, & Pullan A.J. (2010). Origin, propagation and regional characteristics of porcine gastric slow wave activity determined by high-resolution mapping. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 22(10), e292-e300.
Publication 2010
Anesthesia Anesthetics Animal Ethics Committees Animals Blood Pressure Femoral Artery Isoflurane Laparotomy Magnesium Oxygen Propofol Rate, Heart Rectum Remifentanil Signs, Vital Stomach Sus scrofa Tiletamine Zolazepam Zoletil
2
Comprehensive Metabolic Assessment of Rat Health
Cited 7 times
Daily measurements of body weight and intakes of food and water were performed to monitor the day-to-day health of rats. Feed conversion efficiency (%) was calculated as previously described14 (link). Percent body weight increase over 16 weeks was calculated as body weight difference between day 0 and day 112. Abdominal circumference was measured every 4 weeks using a standard measuring tape under light anaesthesia with Zoletil (tiletamine 10 mg/kg, zolazepam 10 mg/kg i.p; Virbac, Peakhurst, NSW, Australia).
Oral glucose tolerance tests were performed on rats as previously described14 (link). Briefly, rats were deprived of food for 12 hours before basal blood glucose concentration measurements followed by oral gavage of 40% aqueous glucose solution and measuring glucose concentrations again at 30, 60, 90 and 120 minutes, with calculation of AUC (area under the curve) from these measurements. Systolic blood pressure was measured every 4 weeks under light sedation with Zoletil (10 mg/kg tiletamine, 10 mg/kg zolazepam, i.p.)14 (link). Echocardiography was performed to measure the cardiovascular structure and function14 (link). Indirect calorimetry was used to measure oxygen consumption and carbon dioxide production using a 4-chamber Oxymax system (Columbus Instruments, Columbus, OH) with one rat per chamber. Rats had ad libitum access to food and water during the measurement. Oxygen consumption (VO2) and carbon dioxide production (VCO2) were measured individually from each chamber. The respiratory exchange ratio (RER = VCO2/VO2) was calculated by Oxymax software (v. 4.86). The oxidation of carbohydrates produces an RER of 1.00, whereas fatty acid oxidation results in an RER of about 0.7038 . Energy expenditure was calculated by assessment of the exchange of oxygen for carbon dioxide that occurs during the metabolic processing of food.
Rats were euthanised after 16 weeks using Lethabarb® (100 mg/kg pentobarbitone sodium, i.p.). After euthanasia, blood was collected to isolate plasma and the plasma was stored at −20 °C before further analysis. Hearts were isolated to perform Langendorff heart preparation to measure diastolic stiffness constant14 (link). Following this, tissues such as liver, left ventricle (with septum), right ventricle and abdominal fat pads (including retroperitoneal, epididymal and omental) were removed for weighing and expressed as mg/mm of tibial length. Plasma concentrations of leptin, insulin, total cholesterol, triglycerides and non-esterified fatty acids (NEFA) were measured as described previously14 (link).
Sekar S., Shafie S.R., Prasadam I., Crawford R., Panchal S.K., Brown L, & Xiao Y. (2017). Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats. Scientific Reports, 7, 46457.
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Publication 2017
Abdomen Abdominal Fat Anesthesia BLOOD Blood Glucose Calorimetry, Indirect Carbohydrates Carbon dioxide Cardiovascular System Cholesterol Diastole Eating Echocardiography Energy Metabolism Epididymis Euthanasia Fatty Acids Fatty Acids, Esterified Food Glucose Heart Human Body Insulin Left Ventricles Leptin Light Liver Omentum Oral Glucose Tolerance Test Oxygen Oxygen Consumption Pad, Fat Pentobarbital Sodium Plasma Rattus Respiratory Rate Retroperitoneal Space Sedatives Systolic Pressure Tibia Tiletamine Tissues Triglycerides Tube Feeding Ventricles, Right Zolazepam Zoletil
3
Cerebrospinal Fluid Sampling After CNO Administration
Cited 6 times
In other experiments, CNO challenges were conducted under anesthesia to collect cerebrospinal fluid (CSF) samples. Animals received a subcutaneous injection of CNO (10 or 3 mg/kg) and were then sedated with tiletamine HCl and zolazepam HCl (Telazol, 3–5 mg/kg, i.m.). Once the animals were anesthetized, the cervical spine area was shaved and disinfected with betadine solution and alcohol. Each CSF sample was obtained from the cisterna magna, using a sterile 23-ga bevel-tipped needle by pressure difference and collected by gravity.31 (link) CSF samples were collected in prechilled sterile Eppendorf tubes, immediately frozen on dry ice, and stored at −80 °C until the time of the assay.
Serial CSF taps were performed in sessions separated by 2 weeks. To reduce the risks associated with repeated spinal taps, and given the time restrictions imposed by the anesthetized state, in each session, only 2–3 serial CSF taps were conducted per animal, so that not all time points were collected for all monkeys.
Thus, after subcutaneous injection of CNO 10 mg/kg, five individual CSF samples were available for analyses at 120 min postinjection, four at 60 min postinjection, three at 10, 30, and 45 min postinjection, and two at 90, 160, and 1440 min. One 90 min postinjection CSF sample was discarded due to blood contamination. Six months later, serial CSF taps were again performed after a subcutaneous injection of CNO, 3 mg/kg, in sessions separated by 2 weeks. After the 3 mg/kg CNO injection, five individual CSF samples were available for analyses at 1440 and 160 min postinjection, four at 90 min postinjection, and three at 30 min postinjection.
Blood samples were collected from the femoral vein immediately following each CSF tap. All blood samples were collected in prechilled 2 mL tubes containing EDTA (3.5 mg) and immediately placed on ice. Samples were centrifuged at 3000 rpm for 15 min in a refrigerated centrifuge (at 4 °C). Plasma was pipetted off and stored at −80 °C until assayed.
Raper J., Morrison R.D., Daniels J.S., Howell L., Bachevalier J., Wichmann T, & Galvan A. (2017). Metabolism and Distribution of Clozapine-N-oxide: Implications for Nonhuman Primate Chemogenetics. ACS chemical neuroscience, 8(7), 1570-1576.
Publication 2017
Anesthesia Animals Betadine BLOOD Cerebrospinal Fluid Cervical Vertebrae Dry Ice Edetic Acid Ethanol Freezing Gravity Magna, Cisterna Monkeys Needles Plasma Pressure Punctures, Lumbar Sterility, Reproductive Subcutaneous Injections Telazol Tiletamine Vein, Femoral Zolazepam
4
Largest Jaguar Movement Dataset Analyzed
Cited 5 times
We used GPS tracking to monitor 44 Jaguars from 1998 to 2016 and across different habitats representing five biomes in Brazil and Argentina. Our dataset represents the largest collection of jaguar movement data analyzed to date. Biomes included the Amazon (4 males: 4 females), Atlantic Forest (6:6), Caatinga (2:0), Cerrado (1:0), and Pantanal (9:12) (Fig 1 and Table 1).
The GPS collection schedules and time periods each animal was monitored ranged from one position every half hour to one position every 24 hours. Estimated ages of jaguars ranged from 18 months to 10 years, with the majority of jaguar (n = 41) being adults (> 3 years old). Two individuals (Esperança and Xango) were monitored for two different periods. Monitoring periods ranged from 11 to 1,749 days (mean = 183 days), while the number of recorded locations ranged from 53 to 10,989 (mean = 2,264). The total dataset consisted of 80,553 locations. Further details on fix schedules, the number of days each animal was monitored, and the devices used to monitor movement, are provided in S1 Table. All animals were captured following standard protocols approved by the Instituto Chico Mendes de Conservação da Biodiversidade—Ministério do Meio Ambiente—Brazil (ICMBio-SISBIO license numbers: 30896–3, 46031–4, 36740–1, 44677–1,14202–4, 38006–1, 30053–1, 37867–1), the National Park Administration (NPA license 03/09), and Misiones Province Government (ME license 119/2012) from Argentina.
Collar fitting involved using trained dogs [38 (link)], box traps [30 ] and/or foot snares [39 ] to facilitate animal capture. All individuals were anaesthetized with a combination of tiletamine and zolazepam (10 mg kg-1), administered via an aluminum dart fired from an air-powered rifle [38 (link)]. We examined each immobilized animal for general body condition, determined its sex and age, collected its weight, and fit each jaguar with a global positioning system collar. Animals were released at the site of capture. All procedures followed guidelines approved by the American Society of Mammologists [40 ].
Morato R.G., Stabach J.A., Fleming C.H., Calabrese J.M., De Paula R.C., Ferraz K.M., Kantek D.L., Miyazaki S.S., Pereira T.D., Araujo G.R., Paviolo A., De Angelo C., Di Bitetti M.S., Cruz P., Lima F., Cullen L., Sana D.A., Ramalho E.E., Carvalho M.M., Soares F.H., Zimbres B., Silva M.X., Moraes M.D., Vogliotti A., May JA J.r., Haberfeld M., Rampim L., Sartorello L., Ribeiro M.C, & Leimgruber P. (2016). Space Use and Movement of a Neotropical Top Predator: The Endangered Jaguar. PLoS ONE, 11(12), e0168176.
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Publication 2016
Adult Aluminum Animal Diseases Animals Biome Canis familiaris Females Foot Forests Human Body Jaguars Males Medical Devices Movement SNAP Receptor Tiletamine Zolazepam
5
Intracerebral Injection of Amyloid-β in Mice
Cited 5 times
Synthetic Aβ(1–42) was dissolved in sterile normal saline at 0, 0.25, 0.5, 2 and 4 nmole (5 μL of 0, 50, 100, 400 and 800 μM). Mice were anesthetized with a mixture of tiletamine·HCL, zolazepam·HCL (80 mg/kg, IP, Zoletil 50®, Virbac) and xylazine (20 mg/kg, IP, Rompun®, Bayer Parma) before ICV injection. Dissolved Aβ(1–42) was injected into the ICV region of mouse brains according to the previously reported protocols23 (link)24 (link). In detail, we used a Hamilton syringe with a 26-gauge stainless-steel needle to inject the Aβ(1–42) stocks into the ICV region by 1.0 mm posterior to bregma, 1.8 mm lateral to saggital, 3.6 mm ventral and 2.4 mm depth.
Cho S.M., Kim H.V., Lee S., Kim H.Y., Kim W., Kim T.S., Kim D.J, & Kim Y. (2014). Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model. Scientific Reports, 4, 6777.
Publication 2014
Brain Mice, House Needles Normal Saline Rompun Stainless Steel Sterility, Reproductive Syringes Tiletamine Xylazine Zolazepam Zoletil

Most recents protocols related to «Zolazepam»

1
Traumatic Brain Injury in Male Pigs
All procedures on pigs were approved by the Johns Hopkins University Animal Care and Use Committee and by the Animal Care and Use Review Office of the US Army Medical Research and Materiel Command for Award Number W81XWH-19-C-0022 (Fort Detrick, MD). In conducting research using animals, the investigators adhered to the Animal Welfare Act Regulations and other Federal statutes relating to animals and experiments involving animals and the principles set forth in the current version of the Guide for the Care and Use of Laboratory Animals, National Research Council.
Because there can be sex differences in the response to TBI (43 (link), 44 (link)) and TBI in the young and in military personnel is more prevalent in males (45 (link)), the study was conducted in male pigs. A total of 48 pigs weighing 28 ± 2 kg and approximately 3 months of age were used in the overall study. The experimental protocols for the TBI + HS experiment and the TBI alone experiment are delineated in Figure 1. The pigs were sedated with intramuscular injection of Telazol (50 mg/ml tiletamine and 50 mg/ml zolazepam, 4.4 mg/kg each component), ketamine 2.2 mg/kg and xylazine 2.2 mg/kg. Isoflurane (4% in 30% O2) was administered via face mask to produce an anesthetic depth for oral intubation of the trachea. After a surgical plane of anesthesia was achieved, as assessed by the lack of limb withdrawal to hoof pinching and by looseness of muscle tone in the jaw, anesthesia was maintained with 2% isoflurane in approximately 30% O2 with mechanical ventilation of the lungs. The antibiotic Baytril 10 mg/kg (100 mg/ml) was injected intramuscularly. Surgery was conducted using aseptic techniques. Through a 5-cm neck incision, an external jugular vein was isolated by blunt dissection. The vein was ligated and a catheter was advanced toward the heart and secured with another ligature. For arterial catheterization, we chose the axillary artery because occlusion of the carotid artery could limit cerebral blood flow after TBI and catheterization of the femoral artery can limit use of the hindlimb. An incision was made in the axilla, and the axillary artery was isolated, ligated, and cannulated with a flexible polyvinyl catheter that minimized kinking. The arterial and venous catheters were tunneled subcutaneously to the back of the neck, where they exited through a small incision. Pigs were able to bear weight on the forelimb and ambulate on the day after surgery.
Wang J., Shi Y., Cao S., Liu X., Martin L.J., Simoni J., Soltys B.J., Hsia C.J, & Koehler R.C. (2023). Polynitroxylated PEGylated hemoglobin protects pig brain neocortical gray and white matter after traumatic brain injury and hemorrhagic shock. Frontiers in Medical Technology, 5, 1074643.
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Publication 2023
Anesthesia Anesthetics Animals Animals, Laboratory Antibiotics Arterial Occlusion Arteries Asepsis Axilla Axillary Artery Baytril Bears Carotid Arteries Catheterization Catheters Cerebrovascular Circulation Common Carotid Artery Dental Occlusion Dissection Face Femoral Artery Heart Hindlimb Hoof Intramuscular Injection Intubation, Intratracheal Isoflurane Jugular Vein Ketamine Ligature Males Mechanical Ventilation Military Personnel Muscle Tonus Neck Operative Surgical Procedures Pigs Polyvinyls Telazol Tiletamine Upper Extremity Veins Xylazine Zolazepam
2
Induced Ventricular Fibrillation in Rabbits
Male New Zealand rabbits (2.5–3.0 kg) were anesthetized using zolazepam, tiletamine, and pentobarbital (all 20–30 mg/kg IV). They received buprenorphine (30 μg/kg IV) for analgesia. Animals were intubated and mechanically ventilated. After the administration of rocuronium bromide (1 mg/kg IV), 2 electrodes were implanted upon the inner muscular wall or inserted into the esophagus, respectively. Body temperatures and ECG were monitored as well as systemic blood pressure through a catheter inserted into the ear artery. After a period of stabilization, an alternative current (12 V, 4 mA; 2.5 minutes) was delivered between the 2 electrodes to induce ventricular fibrillation. Concomitantly, mechanical ventilation was stopped. After 10 minutes of untreated fibrillation, cardiopulmonary resuscitation was performed using external cardiac massage (200 external chest compressions/min), electric defibrillation (10 J/kg), and intravenous administration of epinephrine (15 μg/kg IV). After resumption of spontaneous circulation (ROSC), epinephrine administration was allowed to achieve a target mean blood pressure of 70 mm Hg. Animals were maintained under normothermic conditions thanks to thermal pads. Animals were followed during 2 to 72 hours according to the investigated parameters, that is, during 72 hours for the assessment of neurological recovery after awakening or during 2 to 6 hours without awakening for the evaluation of cerebral infiltration by immune cells or blood–brain barrier (BBB) permeability after ROSC. In the recovery study (72 hours), rabbits received analgesics every day after CA (buprenorphine; 30 μg/kg IM).
Boissady E., Abi Zeid Daou Y., Faucher E., Kohlhauer M., Lidouren F., El Hedjaj C., Chateau‐Joubert S., Hocini H., Hue S., Ghaleh B, & Tissier R. (2023). High‐Mobility Group Box 1–Signaling Inhibition With Glycyrrhizin Prevents Cerebral T‐Cell Infiltration After Cardiac Arrest. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 12(3), e027749.
Publication 2023
Aftercare Analgesics Animals Arteries Body Temperature Buprenorphine Cardiopulmonary Resuscitation Catheters Cells Chest Electric Countershock Epinephrine Esophagus Heart Massage Intravenous Infusion Males Management, Pain Mechanical Ventilation Muscle Tissue Neurologic Examination New Zealand Rabbits Oryctolagus cuniculus Pentobarbital Permeability Rocuronium Bromide Tiletamine Ventricular Fibrillation Zolazepam
3
Influenza Vaccine Efficacy in Mice
All animals used in this study were female BALB/c mice (Janvier Labs, France) housed in a minimal disease unit at Oslo University Hospital. All experiments were approved by the Norwegian Animal Research Authority.
Mice were anaesthetized by an intraperitoneal (i.p.) injection of ZRF (zolazepam [3.3 mg/mL], tiletamine [3.3 mg/mL], xylazine [0.45 mg/mL], fentanyl [2.6 μg/mL]) at 10 μL/g body weight. Immunizations were performed by first shaving the hind legs of anaesthetized mice, followed by an intramuscular (i.m.) injection of 50 μL DNA (0.5 mg/mL) solution into each quadriceps, immediately followed by five-pulse electroporation of the injection site with an AgilePulse system (Harvard Apparatus BTX, Holliston, MA). Protein vaccination was performed under anesthesia by i.m. injection of 50 μL vaccine solution in each quadriceps. For commercial vaccines, 2 × 50 μL of Flublok (Sanofi Pasteur, France) or a 1:1 mixture of Pandemrix:AS03 (GSK, Belgium) was delivered i.m. Viral influenza challenges were done by infecting anaesthetized mice intranasally (i.n.) with a virus dose of 5× the 50% lethal dose (LD50) in 10 μL per nostril. The LD50 dose was established by the Reed and Muench method and titrations of virus in mice. The viral strains used in this study were A/Puerto Rico/8/1934(H1N1), A/California/07/2009(H1N1), and RG14 [reassorted PR8 virus with H5 from A/Viet Nam/04/2005(H5N1)].
Tjärnhage E., Brown D., Bogen B., Andersen T.K, & Grødeland G. (2023). Trimeric, APC-Targeted Subunit Vaccines Protect Mice against Seasonal and Pandemic Influenza. Journal of Virology, 97(2), e01694-22.
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Publication 2023
Anesthesia Animals Body Weight Electroporation Therapy Females Fentanyl FluBlok Immunization Influenza in Birds Leg Mice, House Mice, Inbred BALB C Orthomyxoviridae pandemrix Proteins Pulse Rate Quadriceps Femoris Strains Tiletamine Titrimetry Vaccination Vaccines Virus Xylazine Zolazepam
4
Rabies Vaccine Challenge in Beagles
Upon arrival, and until the challenge infection, all animals were located in an outdoor animal enclosure. The inside area per cage was 6–8 m2, and the outside area per cage was 17–55 m2. Environmental enrichment items like pull ropes, chewing toys, cloths and dog beds were provided in each cage. If necessary, the inside and outside area of each cage could be separated from each other. The animals were divided by sex in equal groups with a maximum of 5 animals per cage. For the time of vaccine administration, the animals were separated from the others for at least 2–4 h, avoiding possible horizontal transmission. At the time of the challenge, the animals were transferred from the outdoor enclosure to the units of the indoor experimental animal facility at Ceva Innovation Center, Dessau-Rosslau, Germany. The animals were kept in individual cages (ground area: 4 m2). As these units had a total housing capacity for 20 dogs, it was necessary to split the study into 2 parts.
The animals were fed twice a day (Vollmers’ Welpenkost, Gerhard Vollmer GmbH &Co. KG, Spenge, Germany). Water was offered ad libitum. All dogs were observed at least once daily for general health, feed intake and defecation by the staff. In the case of an abnormal clinical finding during the daily animal check, it was determined if the observation was due to a rabies infection and, if not, if the animal needed treatment. In case of severe clinical signs, dogs were humanely killed.
Treatment and sampling in general were done without anesthesia or sedation. Only for the challenge infection, and on single occasions for blood sampling, animals were sedated using Medetomidine (Domitor®, Vetoguinol, Ismaning, Germany) at a dosage of 0.1 mg/kg body weight i.m. during the first part. During the second part of the study, Tiletamin hydrochloride + Zolazepam hydrochloride (Zoletil 100 [50 mg/mL + 50 mg/mL], Virbac Arzneimittel GmbH, Bad Oldesloe, Germany) was used in a dosage of 7.5 mg/kg. Induction of euthanasia was done by Xylazine (2%, 2 mg/kg) and Ketamine (10%, 10 mg/kg) i.m. (Serumwerk Bernburg AG, Bernburg, Germany). For euthanasia, T61® (Intervet GmbH, Unterschleissheim, Germany) was used in deep general anesthesia and was administered at a dosage of 0.3 mL/kg body weight.
At the end of the experiment, all dogs that survived the challenge were humanely killed, as described above, except for the 5 surplus animals that were not challenged. These animals were handed over to new owners through a specialized organization (Labor-Beagle-Hilfe e.V.) after termination of the study.
Bobe K., Ortmann S., Kaiser C., Perez-Bravo D., Gethmann J., Kliemt J., Körner S., Theuß T., Lindner T., Freuling C., Müller T, & Vos A. (2023). Efficacy of Oral Rabies Vaccine Baits Containing SPBN GASGAS in Domestic Dogs According to International Standards. Vaccines, 11(2), 307.
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Publication 2023
Anesthesia Animals Animals, Laboratory Body Weight Canis familiaris Defecation Euthanasia Feed Intake General Anesthesia Hydrophobia Infection Infectious Disease Transmission, Horizontal Ketamine Medetomidine Obstetric Labor Sedatives Vaccines Xylazine Zolazepam Zoletil
5
General Anesthesia for Small Animals
General anesthesia was made using atropine (0.04 mg/kg) as premedication and anesthesia mixture of tiletamine/zolazepam, xylazine and butorphanol and standard sterilization with ethyl alcohol and braunol solution, after shaving of the hair. Preparation of anesthesia: in a vial powder Zoletil 50 (tiletamine HCl 125 mg, zolazepam base 125 mg) is administrated 10 mL Xylazine 2% and 0.75 mL Butomidor (Butorphanol 10 mg/mL) in doses of 0.1–0.2 mL/kg.
Ruseva K., Todorova K., Zhivkova T., Milcheva R., Ivanov D., Dimitrov P., Alexandrova R, & Vassileva E. (2023). Novel Triple Stimuli Responsive Interpenetrating Poly(Carboxybetaine Methacrylate)/Poly(Sulfobetaine Methacrylate) Network. Gels, 9(2), 90.
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Publication 2023
Anesthesia Atropine Butorphanol Ethanol General Anesthesia Hair Powder Premedication Sterilization Tiletamine tiletamine - zolazepam Xylazine Zolazepam Zoletil

Top products related to «Zolazepam»

1
Rompun by Bayer
Sourced in Germany, France, United States, United Kingdom, Canada, Italy, Brazil, Belgium, Cameroon, Switzerland, Spain, Australia, Ireland, Sweden, Portugal, Netherlands, Austria, Denmark, New Zealand
Rompun is a veterinary drug used as a sedative and analgesic for animals. It contains the active ingredient xylazine hydrochloride. Rompun is designed to induce a state of sedation and pain relief in animals during medical procedures or transportation.
2
Zoletil by Virbac
Sourced in France, United States, Italy, Australia, Germany, China, Thailand, Cameroon, United Kingdom, Netherlands, New Zealand
Zoletil is a general anesthetic and analgesic used in veterinary medicine. It is a combination of two active compounds, tiletamine and zolazepam, that work together to induce a state of deep sedation and pain relief in animals. The product is administered by injection and is commonly used for a variety of veterinary procedures, including surgery, diagnostic imaging, and minor treatments. Zoletil is intended for use under the supervision of licensed veterinary professionals.
3
Zoletil 50 by Virbac
Sourced in France, United States, Germany, Denmark, Brazil, China, Cameroon
Zoletil 50 is a veterinary anesthetic medication used in dogs, cats, and other animals. It contains the active ingredients tiletamine and zolazepam. Zoletil 50 is used to induce general anesthesia and provide sedation for medical procedures.
4
Zoletil 100 by Virbac
Sourced in France, Italy, Belgium, United Kingdom, Spain, Australia
Zoletil 100 is a veterinary anesthetic agent. It is a combination of two active substances, tiletamine and zolazepam. Zoletil 100 is used to induce and maintain anesthesia in animals.
5
Zolazepam by Virbac
Sourced in France, Denmark
Zolazepam is a pharmaceutical product used as a laboratory equipment for research and development purposes. It serves as a sedative-hypnotic agent that can be utilized in controlled experimental settings. The core function of Zolazepam is to induce a state of sedation and sleep in laboratory animals, allowing for the study of various physiological and behavioral responses.
6
Telazol by Zoetis
Sourced in United States
Telazol is a sterile, injectable anesthetic agent composed of equal parts of the active ingredients tiletamine hydrochloride and zolazepam hydrochloride. It is intended for use in veterinary medicine as a general anesthetic and for the chemical restraint of animals.
7
Tiletamine by Virbac
Sourced in France, Denmark, Belgium
Tiletamine is a synthetic drug used as a general anesthetic in veterinary medicine. It is primarily used as a component in combination anesthetic agents for small and large animals. Tiletamine exhibits dissociative anesthetic properties, allowing for safe and effective sedation during procedures.
8
Rumpun by Bayer
Sourced in France, Germany, Cameroon, United States
Rumpun is a lab equipment product manufactured by Bayer. It is a general-purpose centrifuge designed for the separation and isolation of biological samples in a laboratory setting.
9
Mydrin p by Santen
Sourced in Japan, Germany
Mydrin-P is a laboratory product used for ophthalmic purposes. It functions as a mydriatic agent, intended to dilate the pupil.
10
Xylazine by Bayer
Sourced in Germany, France, Japan, United States, Brazil, Spain, Canada, Switzerland, Cameroon, Australia, United Kingdom
Xylazine is a pharmaceutical product used as a sedative and analgesic in veterinary medicine. It is a central alpha-2 adrenergic agonist that produces a calming effect and pain relief in animals. Xylazine is used to facilitate handling, examination, and minor surgical procedures in various animal species.

More about "Zolazepam"

Zolazepam is a potent anxiolytic and sedative drug used to treat anxiety disorders and insomnia.
It enhances the activity of the inhibitory neurotransmitter GABA in the brain, leading to a calming effect.
This medication is also known by its brand names Rompun, Zoletil, Zoletil 50, and Zoletil 100.
Researchers can utilize PubCompare.ai's AI-driven protocol comparison tool to optimize their Zolazepam studies, improving reproducibility and accuracy by identifying the best research protocols and products from the literature, pre-prints, and patents.
This powerful workflow streamliner helps deliver reliable results for Zolazepam research, also known as Telazol or Tiletamine.
Additionally, Rumpun and Mydrin-P are related drugs that share similar mechanisms of action and therapeutic uses with Zolazepam.
By incorporating these synonyms and related terms, researchers can enhance their understanding and optimize their studies on this important anxiolytic and sedative medication.