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Zoletil

Zoletil is a veterinary anesthetic and sedative drug used in a variety of animal species.
It is a combination of two dissociative anesthetics, tiletamine and zolazepam, which produce a state of anesthesia and muscle relaxation.
Zoletil is commonly used for the immobilization of wild and domesticated animals during medical procedures, transportation, or research.
The drug has a rapid onset of action and a relatively long duration of effect, making it a useful tool for veterinary professionals.
However, Zoletil use requires careful dosing and monitoring to ensure the safety and well-being of the animal patient.
Researchers should consult the latest protocols and best practices to optimize the use of Zoletil and enhance the reproducibility and accuracy of their animal studies.

Most cited protocols related to «Zoletil»

1
SARS-CoV-2 Infection Dynamics in Young and Aged Cynomolgus Macaques
Cited 12 times
The SARS-CoV-2 strain 107 was obtained from the Guangdong Provincial CDC, Guangdong, China. Young ChRMs (#15011, #15333, #15335, and #15341) and aged ChRMs (#01055, #02059, #03055, and #04305) (Figure 1A) were intratracheally inoculated with 1×107 TCID50 SARS-CoV-2 in a 2 mL volume by bronchoscope. The animals were anaesthetized by Zoletil 50 (Virbac, France) and then used in the following experimental procedures. Body weight, rectal temperature, breathing rate, X-ray, serum biochemistry tests, routine blood tests, peripheral blood collection, peripheral blood mononuclear cell (PBMC) collection, nose swab collection, throat swab collection, and rectal swab collection were performed before SARS-CoV-2 infection and at 1, 3, 5, 7, 9, 11, 13, and 15 days post infection (dpi). Tracheal brush collection and blood gas analysis were performed before SARS-CoV-2 infection and at 3, 7, 11, and 15 dpi. Young (#15011 and #15335) and aged ChRMs (#02059 and #04305) were euthanized on 7 dpi and other animals on 15 dpi (Figure 1). All seven lung lobes were collected after left heart perfusion with pre-cooled phosphate-buffered saline (PBS).
Song T.Z., Zheng H.Y., Han J.B., Jin L., Yang X., Liu F.L., Luo R.H., Tian R.R., Cai H.R., Feng X.L., Liu C., Li M.H, & Zheng Y.T. (2020). Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques. Zoological Research, 41(5), 503-516.
Publication 2020
Animals Blood Blood Gas Analysis Body Weight Bronchoscopes COVID 19 Heart Hematologic Tests Infection Lung Nose PBMC Peripheral Blood Mononuclear Cells Perfusion Pharynx Phosphates Radiography Rectum Respiratory Rate Saline Solution SARS-CoV-2 Serum Strains Trachea Zoletil
2
In Vivo Porcine Anesthesia and Euthanasia Protocol
Cited 11 times
All experiments were performed in vivo. Ethical approval
was obtained from The University of Auckland Animal Ethics Committee and the
International Guiding Principles for Biomedical Research Involving Animals were
followed. Sixteen white cross-breed weaner pigs were employed, of either sex and
of mean weight 36.7 ± 0.5 kg. The pigs were fasted then subjected to
general anesthesia that was induced with Zoletil (Tiletamine HCl 50 mg
mL−1 and Zolazepam HCl 50 mg mL−1),
and maintained with Isoflurane (2.5–5% with an oxygen flow of
400 mL within a closed circuit anesthetic system). A possible alternative
regimen of remifentanil/propofol has been found to be associated with pyloric
spasm in pigs and therefore was not considered.6 (link)A femoral artery was cannulated and vital signs were continuously
monitored including heart rate and blood pressure. Rectal and intra-abdominal
temperatures were also monitored, and these were kept in the normal
physiological range (38.5–39.5 °C) by continuous use of a
heating pad and the additional use of a heat lamp when necessary. A midline or
bilateral subcostal laparotomy was performed depending on the gastric region of
experimental interest, the latter incision being more suitable for
investigations of the proximal stomach. At the conclusion of the experiments,
the animals were euthanized with a bolus injection of 50 mL of magnesium sulfate
while still under anesthesia.
Egbuji J.U., O’Grady G., Du P., Cheng L.K., Lammers W.J., Windsor J.A, & Pullan A.J. (2010). Origin, propagation and regional characteristics of porcine gastric slow wave activity determined by high-resolution mapping. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 22(10), e292-e300.
Publication 2010
Anesthesia Anesthetics Animal Ethics Committees Animals Blood Pressure Femoral Artery Isoflurane Laparotomy Magnesium Oxygen Propofol Rate, Heart Rectum Remifentanil Signs, Vital Stomach Sus scrofa Tiletamine Zolazepam Zoletil
3
Comprehensive Metabolic Assessment of Rat Health
Cited 7 times
Daily measurements of body weight and intakes of food and water were performed to monitor the day-to-day health of rats. Feed conversion efficiency (%) was calculated as previously described14 (link). Percent body weight increase over 16 weeks was calculated as body weight difference between day 0 and day 112. Abdominal circumference was measured every 4 weeks using a standard measuring tape under light anaesthesia with Zoletil (tiletamine 10 mg/kg, zolazepam 10 mg/kg i.p; Virbac, Peakhurst, NSW, Australia).
Oral glucose tolerance tests were performed on rats as previously described14 (link). Briefly, rats were deprived of food for 12 hours before basal blood glucose concentration measurements followed by oral gavage of 40% aqueous glucose solution and measuring glucose concentrations again at 30, 60, 90 and 120 minutes, with calculation of AUC (area under the curve) from these measurements. Systolic blood pressure was measured every 4 weeks under light sedation with Zoletil (10 mg/kg tiletamine, 10 mg/kg zolazepam, i.p.)14 (link). Echocardiography was performed to measure the cardiovascular structure and function14 (link). Indirect calorimetry was used to measure oxygen consumption and carbon dioxide production using a 4-chamber Oxymax system (Columbus Instruments, Columbus, OH) with one rat per chamber. Rats had ad libitum access to food and water during the measurement. Oxygen consumption (VO2) and carbon dioxide production (VCO2) were measured individually from each chamber. The respiratory exchange ratio (RER = VCO2/VO2) was calculated by Oxymax software (v. 4.86). The oxidation of carbohydrates produces an RER of 1.00, whereas fatty acid oxidation results in an RER of about 0.7038 . Energy expenditure was calculated by assessment of the exchange of oxygen for carbon dioxide that occurs during the metabolic processing of food.
Rats were euthanised after 16 weeks using Lethabarb® (100 mg/kg pentobarbitone sodium, i.p.). After euthanasia, blood was collected to isolate plasma and the plasma was stored at −20 °C before further analysis. Hearts were isolated to perform Langendorff heart preparation to measure diastolic stiffness constant14 (link). Following this, tissues such as liver, left ventricle (with septum), right ventricle and abdominal fat pads (including retroperitoneal, epididymal and omental) were removed for weighing and expressed as mg/mm of tibial length. Plasma concentrations of leptin, insulin, total cholesterol, triglycerides and non-esterified fatty acids (NEFA) were measured as described previously14 (link).
Sekar S., Shafie S.R., Prasadam I., Crawford R., Panchal S.K., Brown L, & Xiao Y. (2017). Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats. Scientific Reports, 7, 46457.
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Publication 2017
Abdomen Abdominal Fat Anesthesia BLOOD Blood Glucose Calorimetry, Indirect Carbohydrates Carbon dioxide Cardiovascular System Cholesterol Diastole Eating Echocardiography Energy Metabolism Epididymis Euthanasia Fatty Acids Fatty Acids, Esterified Food Glucose Heart Human Body Insulin Left Ventricles Leptin Light Liver Omentum Oral Glucose Tolerance Test Oxygen Oxygen Consumption Pad, Fat Pentobarbital Sodium Plasma Rattus Respiratory Rate Retroperitoneal Space Sedatives Systolic Pressure Tibia Tiletamine Tissues Triglycerides Tube Feeding Ventricles, Right Zolazepam Zoletil
4
Unilateral Cochlear Ablation in Mice
Cited 6 times
Male B57BL/6 mice (postnatal 8-week-old) were used in the present study. All anesthetic, surgical, and postsurgical procedures used in this study, as well as animal care, were approved by the Institutional Animal Care Committee of Seoul National University of Korea (IACUC No. 15-0204-C2A4). The mice were divided into three groups: control, SSD-4-week, and SSD-8-week. The control group (postnatal 8-week-old, n = 9) mice were subjected to MEMRI immediately. The SSD-4-week group underwent left-side cochlear ablation surgery and recovered for 4 more weeks until MEMRI study (postnatal 12-week-old, n = 11). The SSD-8-week group recovered for 8 weeks after left cochlear ablation surgery before MEMRI study (postnatal 16-week-old, n = 11) (Figure 1).
The mice were anesthetized with an intraperitoneal injection of a mixture of Zoletil (30 mg/kg) and xylazine (5 mg/kg). All cochlear ablation surgeries were conducted unilaterally on the left ear. After the fur was shaved behind the left ear, a postauricular incision was made. The otic bulla was dissected with care to preserve the facial nerve. A small opening was made in the otic bulla, and the cochlea was visualized. The cochlea was punctured with a 26-gauge needle and was irrigated with kanamycin through the perforation three times. Then, the opening in the cochlea was closed with glue, and a subcutaneous 4.0 Vicryl suture was added. Hearing levels were confirmed before MEMRI acquisitions in all mice groups using the auditory brainstem response (ABR) (SmartEP, Intelligent Hearing Systems, Miami, FL, USA) as described previously [5 (link)]. The ABR results are presented in Table 1. The average ABR thresholds of the deaf side were 81.36 (standard deviation (SD) = 10.02) dB SPL and 80.00 (SD = 10.00) dB SPL for SSD-4-week and SSD-8-week groups, respectively.
Kim S.Y., Heo H., Kim D.H., Kim H.J, & Oh S.H. (2018). Neural Plastic Changes in the Subcortical Auditory Neural Pathway after Single-Sided Deafness in Adult Mice: A MEMRI Study. BioMed Research International, 2018, 8624745.
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Publication 2018
Anesthetics Animal Care Committees Animals Auditory Brainstem Responses Brain Stem Cochlea Ear Facial Nerves Hearing Impaired Persons Injections, Intraperitoneal Institutional Animal Care and Use Committees Kanamycin Males Mice, House Needles Operative Surgical Procedures Sutures Vicryl Xylazine Zoletil
5
Spinal Cord Injury Protein Analysis
Cited 6 times
The animals were fully anesthetized using Zoletil 50 (10 mg/ kg, intraperitoneally; Vibac Laboratories), and then the spinal cord at T9–10 level was dissected. Western blot analysis was performed according to the previously described method (Jung et al., 2016 (link)). The spinal cord tissues covering approximately 1 cm of the rostral and caudal spinal cord at the injury area were prepared and washed with ice-cold PBS and sonicated in 400–600 mL of Triton lysis buffer. Protein separation was performed using a 10% polyacrylamide with 0.05% bis-acrylamide. Proteins were then transferred to nitrocellulose and the blots were probed with anti-Bax rabbit polyclonal antibody (1:1,500, Santa Cruz Biotechnology, Santa Cruz, CA, USA), anti-Bcl-2 mouse monoclonal antibody (1:1,500, Santa Cruz Biotechnology), anti-BDNF rabbit polyclonal antibody (1:1,000, Santa Cruz Biotechnology), anti-TrkB rabbit polyclonal antibody (1:1,000, Santa Cruz Biotechnology), anti-p-ERK1/2 rabbit monoclonal antibody (1:3,000, Cell Signaling Technology, Beverly, MA, USA), anti-p-JNK rabbit monoclonal antibody (1:2,000, Cell Signaling Technology), anti-p-c-Jun rabbit monoclonal antibody (1:2,000, Cell Signaling Technology), and anti-β-actin mouse monoclonal antibody (1:3,000, Santa Cruz Biotechnology). Peroxidase anti-rabbit IgG (1:5,000 Vector Laboratories, Burlingame, CA, USA), and peroxidase anti-mouse IgG (1:5,000, Vector Laboratories) were used as the secondary antibodies.
Kim Y.M., Jin J.J., Lee S.J., Seo T.B, & Ji E.S. (2018). Treadmill exercise with bone marrow stromal cells transplantation facilitates neuroprotective effect through BDNF-ERK1/2 pathway in spinal cord injury rats. Journal of Exercise Rehabilitation, 14(3), 335-340.
Publication 2018
Acrylamide Actins Animals anti-c antibody anti-IgG Antibodies Antibodies, Anti-Idiotypic bcl-2 Gene Buffers Cloning Vectors Common Cold Mitogen-Activated Protein Kinase 3 Monoclonal Antibodies Mus Nitrocellulose Peroxidase polyacrylamide Proteins Rabbits Spinal Cord Spinal Cord Injuries Tissues tropomyosin-related kinase-B, human Western Blot Zoletil

Most recents protocols related to «Zoletil»

1
Venous Ablation Device Evaluation in Dogs
All animal experimental procedures were conducted in compliance with the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health and were approved by the Institutional Animal Care and Use Committee of the Cardiovascular Product Evaluation Center, Yonsei University (No. CPEC-IACUC-181005).
Seven healthy male mongrel dogs weighing 30 ± 5 kg were enrolled in the present study. The dogs were acclimated for 7 days before the experiments. Each dog was bred in a separate stainless-steel breeding box and was maintained at an environmental temperature of 20–24 ℃, relative humidity of 30%–70%, and a 12/12-hour light-dark cycle.
After induction of anesthesia through intramuscular administration of atropine 0.02–0.04 mg/kg (Jeil Pharmaceutical Co., Ltd.), Domitor 0.1 µg/kg (Elanco), Zoletil 10 mg/kg (Virbac), Rumpun 0.1–1.0 mg/kg (Bayer), Alfaxan 5.0 mg/kg (Jurox), and tramadol 1.0–3.0 mg/kg (Hanall Biopharma), respiratory anesthesia was maintained at 5–10 mL/kg/min with Forane (JW Pharmaceutical) and an O2 in a ratio of 1–2:1 using Primus (Dräger).
The experiment was carried out by inserting 1 control device (CF) and 1 experimental device (VS) for each dog into the femoral and cephalic veins and removing the catheter after ablation. Of the 7 dogs, 1 was sacrificed on the same day of the procedure, and the other 6 dogs were followed up for 2 weeks, with the experiment terminated following autopsy (Table 1).
Hwang J.H., Park S.W., Min J., Yang W.Y., Kwon Y.W., Hwang J.J., Kim J.S., Lee S.A, & Chee H.K. (2023). Endovenous radiofrequency ablation using a new bipolar electrode in a canine model: a new endovenous radiofrequency electrode. Annals of Surgical Treatment and Research, 104(3), 164-169.
Publication 2023
Anesthesia Animals Animals, Laboratory Atropine Autopsy Canis familiaris Cardiovascular System Catheter Ablation cyclopentenyl cytosine Femur Humidity Institutional Animal Care and Use Committees Males Medical Devices Pharmaceutical Preparations Respiratory Rate Stainless Steel Tramadol Veins Zoletil
2
In utero CRISPR-mediated fetal monkey engineering
The pregnancy after timed mating was assessed periodically by ultrasound examination, and pregnancy was confirmed with ultrasound evidence of fetal heart activity. Pregnant monkeys having fetal monkeys at embryonic day 55 (E55) or gestational day 55 (G55) were selected for in utero injection. After induction of anesthesia of the pregnant monkey with intramuscular injection of Zoletil®50 at a dose of 5 mg/kg, a 25-G Quincke needle (BectonDickenson) was used to target the LV of the fetal monkey brain closest to the anterior maternal abdomen under continuous ultrasound imaging. Lentiviruses (50 μL lentivirus CHD8 or control gRNA mixed with 100 μL lentiviral Cas9 were injected as a slow bolus to deliver a total dose of 1.0 × 108 vg (lentiviral gRNA) and 2.0 × 108 vg (lentiviral Cas9) in each fetus. The correct delivery would result in ventricular swelling, and the needle was removed immediately. The injected fetus was monitored for another 15 min. We obtained two male and one female newborn monkeys, which were delivered naturally. These newborn monkeys were euthanized with intramuscular injection of Barbiturates with the dose of 100 mg/kg at postnatal day 7 or 8 to isolate their brains for analysis.
Li B., Zhao H., Tu Z., Yang W., Han R., Wang L., Luo X., Pan M., Chen X., Zhang J., Xu H., Guo X., Yan S., Yin P., Zhao Z., Liu J., Luo Y., Li Y., Yang Z., Zhang B., Tan Z., Xu H., Jiang T., Jiang Y.H., Li S., Zhang Y.Q, & Li X.J. (2023). CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate. Cell Discovery, 9, 27.
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Publication 2023
Abdomen Anesthesia Barbiturates Brain CHD8 protein, human Echocardiography Embryo Females Fetal Heart Fetal Ultrasonography Fetus Heart Heart Ventricle Infant, Newborn Intramuscular Injection Lentivirus Males Monkeys Needles Obstetric Delivery Pregnancy Uterus Zoletil
3
Orthotopic Xenograft OSCC Mouse Model with EGFR Variants

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Publication 2023
Atrophy Cells Cytoplasm Dilatation Fingers Hemorrhage Heterografts HLA-G Antigen Injections, Intraperitoneal Injuries Kidney Light Microscopy Liver Lung Lymph Node Metastasis Males matrigel Mus Necrosis Neoplasms Neutrophil Infiltration Obstetric Delivery Ovum Implantation Pathologists Safety Spleen Therapies, CAR T-Cell Thomsen-Friedenreich antibodies Tissues Tongue Vacuole Zoletil
4
Ultrasound-Guided Anesthetic Monitoring in Primates
The ultrasound procedure was performed using a GE LOGIQ P5 ultrasound imaging system after the onset of short-acting Zoletil anesthetic (0.1 mg/kg i.m.); then, the animal was safely secured to the examination table. Abdominal ultrasonography of monkey 010139 affected by PKD and PLD was performed after it exhibited depression and poor appetite. The other PKD-affected monkey was diagnosed during necropsy; therefore, no relevant ultrasonography results were available. Animal IDs and health status were confirmed before biopsy procedures. Animals were anesthetized with ketamine, 10 mg/kg i.m., and hair on the area of skin that covered the right chest and the liver lobe was removed using a razor. The imaging probe was placed on the abdomen. Ultrasonographic examinations were conducted as previously described (16 ). The liver and other organs were imaged transcutaneously using the GE LOGIQ P5 ultrasound imaging system, with 10 L and 4°C probes (GE Healthcare, USA).
Wu R., Bai B., Li F., Bai R., Zhuo Y., Zhu Z., Jia R., Li S., Chen Y, & Lan X. (2023). Phenotypes and genetic etiology of spontaneous polycystic kidney and liver disease in cynomolgus monkey. Frontiers in Veterinary Science, 10, 1106016.
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Publication 2023
Abdomen Abdominal Cavity Anesthetics Animals Autopsy Biopsy Chest Examination Tables Hair Ketamine Liver Monkeys Physical Examination Skin Zoletil
5
Tissue Distribution of Gadolinium in Rats
Animals were anaesthetised with SevoFlo at an induction rate of 3 to 4% and subsequently by intramuscular injection of 0.20 mL/kg of Zoletil 50/50 (20 mg/kg) and 0.25 mL/kg of Rompun (5 mg/kg). Anaesthetic doses were calculated based on the last recorded body weight. Animals were euthanised and bled after collection of blood from the abdominal aorta. Blood was collected in tubes containing lithium heparin gel and stored at 2 to 8 °C until sample preparation was required for clinical chemistry or inductively coupled plasma/mass spectrometry (ICP-MS) analyses. After exsanguination, a complete macroscopic postmortem examination was performed. Any abnormal findings were recorded. Thereafter, each animal was dissected to obtain the following tissues for ICP-MS determination of Gd: cerebrum, cerebellum, liver, kidneys, peripheral nerves (lumbosacral plexus, sciatic, and tibial nerves from both legs), femur, and skin. Tissues were sampled from all animals using sterile disposable surgical instruments to avoid cross-contamination, weighed, then placed in disposable tubes and frozen at -80 °C ± 10 °C. A total of 461 blood/tissue samples were collected (58 animals; 7 tissue samples [− 3 missing skin samples], and 1 blood sample per animal).
Bonafè R., Coppo A., Queliti R., Bussi S., Maisano F., Kirchin M.A, & Tedoldi F. (2023). Gadolinium retention in a rat model of subtotal renal failure: are there differences among macrocyclic GBCAs?. European Radiology Experimental, 7, 7.
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Publication 2023
Anesthetics Animals Aortas, Abdominal Autopsy BLOOD Body Weight Cerebellum Cerebrum Exsanguination Femur Freezing Heparin Intramuscular Injection Kidney Leg Lithium Liver Mass Spectrometry Peripheral Nerves Plasma Plexus, Lumbosacral Rompun Skin Sterility, Reproductive Surgical Instruments Tibial Nerve Tissues Zoletil

Top products related to «Zoletil»

1
Zoletil by Virbac
Sourced in France, United States, Italy, Australia, Germany, China, Thailand, Cameroon, United Kingdom, Netherlands, New Zealand
Zoletil is a general anesthetic and analgesic used in veterinary medicine. It is a combination of two active compounds, tiletamine and zolazepam, that work together to induce a state of deep sedation and pain relief in animals. The product is administered by injection and is commonly used for a variety of veterinary procedures, including surgery, diagnostic imaging, and minor treatments. Zoletil is intended for use under the supervision of licensed veterinary professionals.
2
Zoletil 50 by Virbac
Sourced in France, United States, Germany, Denmark, Brazil, China, Cameroon
Zoletil 50 is a veterinary anesthetic medication used in dogs, cats, and other animals. It contains the active ingredients tiletamine and zolazepam. Zoletil 50 is used to induce general anesthesia and provide sedation for medical procedures.
3
Rompun by Bayer
Sourced in Germany, France, United States, United Kingdom, Canada, Italy, Brazil, Belgium, Cameroon, Switzerland, Spain, Australia, Ireland, Sweden, Portugal, Netherlands, Austria, Denmark, New Zealand
Rompun is a veterinary drug used as a sedative and analgesic for animals. It contains the active ingredient xylazine hydrochloride. Rompun is designed to induce a state of sedation and pain relief in animals during medical procedures or transportation.
4
Zoletil 100 by Virbac
Sourced in France, Italy, Belgium, United Kingdom, Spain, Australia
Zoletil 100 is a veterinary anesthetic agent. It is a combination of two active substances, tiletamine and zolazepam. Zoletil 100 is used to induce and maintain anesthesia in animals.
5
Freezing microtome by Leica
Sourced in Germany, United States, Japan, Canada, Australia, Spain, Israel
The Freezing Microtome is a laboratory instrument used to prepare thin, uniform sections of frozen biological samples for microscopic examination. It accurately slices the frozen specimen into thin sections, allowing researchers to study the internal structure and composition of the sample.
6
Xylazine by Bayer
Sourced in Germany, France, Japan, United States, Brazil, Spain, Canada, Switzerland, Cameroon, Australia, United Kingdom
Xylazine is a pharmaceutical product used as a sedative and analgesic in veterinary medicine. It is a central alpha-2 adrenergic agonist that produces a calming effect and pain relief in animals. Xylazine is used to facilitate handling, examination, and minor surgical procedures in various animal species.
7
Rumpun by Bayer
Sourced in France, Germany, Cameroon, United States
Rumpun is a lab equipment product manufactured by Bayer. It is a general-purpose centrifuge designed for the separation and isolation of biological samples in a laboratory setting.
8
Cryostat by Leica
Sourced in Germany, United States, Japan, United Kingdom, France, Australia, Canada, Denmark, Italy, Singapore, Switzerland, Israel
The Cryostat is a specialized piece of laboratory equipment used for the sectioning of frozen tissue samples. It maintains a controlled low-temperature environment, enabling the precise and consistent cutting of delicate specimens for microscopic analysis and examination.
9
Rompun 2 by Bayer
Sourced in Germany, France, United States, Portugal
Rompun 2 is a laboratory equipment product manufactured by Bayer. It is designed for use in various research and testing applications.
10
Zoletil by Bayer
Sourced in France, Germany
Zoletil is a veterinary anesthetic agent used for the immobilization of a variety of animal species. It is a combination of two active substances, tiletamine and zolazepam. Zoletil is primarily used to induce a state of anesthesia in animals during medical procedures or examinations.

More about "Zoletil"

Zoletil, a versatile veterinary anesthetic and sedative, is a combination of the dissociative anesthetics tiletamine and zolazepam.
This powerful drug is widely used for the immobilization of wild and domestic animals during medical procedures, transportation, or research.
With its rapid onset and long-lasting effects, Zoletil is a valuable tool for veterinary professionals.
Researchers studying animal models may utilize Zoletil, Zoletil 50, or Rompun (xylazine) to induce a state of anesthesia and muscle relaxation in their subjects.
The cryostat, a specialized instrument used for freezing microtome sections, can also be employed in conjunction with Zoletil during tissue preparation for analysis.
When using Zoletil or its variants, such as Zoletil 100 or Rumpun, it is crucial to follow the latest protocols and best practices to ensure the safety and well-being of the animal patients.
Careful dosing and monitoring are essential to optimize the use of these anesthetic agents and enhance the reproducibility and accuracy of your animal studies.
By staying up-to-date with the latest research and leveraging AI-driven platforms like PubCompare.ai, researchers can access the most current information on Zoletil and other veterinary anesthetics, ultimately improving the quality and reliability of their animal-based investigations.