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> Chemicals & Drugs > Vitamin > Calcifediol

Calcifediol

Calciferol, also known as calcifediol, is a prohormone that is converted to the active form of vitamin D, calcitriol, in the liver.
It plays a crucial role in calcium and phosphate homeostasis, and is important for bone health and immune function.
Optimnize your calcifediol research with PubCompare.ai, an AI-powered tool that enhances reproducibility and accuracy.
Easily locate relevant protocols from literature, preprints, and patents, and use AI-driven comparisons to identify the best protocols and prodcuts for your research.
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Most cited protocols related to «Calcifediol»

1
Genome-wide Analysis of 25-Hydroxyvitamin D Levels
Genome-wide analyses were performed within each cohort according to a uniform analysis plan. We fit additive genetic models using linear regression on natural-log transformed 25-hydroxyvitamin D, and adjusted the models for month of sample collection (12 categories), age, sex, and body mass index, and principal components capturing genetic ancestry. Further adjustments included cohort-specific variables, such as geographical location and assay batch, where relevant. For participating studies with a case-control design, we analyzed cases and controls separately. We performed a fixed-effects inverse variance weighted meta-analysis across the contributing cohorts, as implemented in the software METAL26 (link), with control for population structure within each cohort and quality control thresholds of minor allele frequency (MAF) > 0.05, imputation info score > 0.8, Hardy-Weinberg equilibrium (HWE) > 1×10−6, and a minimum of two studies and 10,000 individuals contributing to each reported SNP-phenotype association. We regarded P-values < 5×10−8 as genome-wide significant.
Jiang X., O’Reilly P.F., Aschard H., Hsu Y.H., Richards J.B., Dupuis J., Ingelsson E., Karasik D., Pilz S., Berry D., Kestenbaum B., Zheng J., Luan J., Sofianopoulou E., Streeten E.A., Albanes D., Lutsey P.L., Yao L., Tang W., Econs M.J., Wallaschofski H., Völzke H., Zhou A., Power C., McCarthy M.I., Michos E.D., Boerwinkle E., Weinstein S.J., Freedman N.D., Huang W.Y., Van Schoor N.M., van der Velde N., Groot L.C., Enneman A., Cupples L.A., Booth S.L., Vasan R.S., Liu C.T., Zhou Y., Ripatti S., Ohlsson C., Vandenput L., Lorentzon M., Eriksson J.G., Shea M.K., Houston D.K., Kritchevsky S.B., Liu Y., Lohman K.K., Ferrucci L., Peacock M., Gieger C., Beekman M., Slagboom E., Deelen J., Heemst D.V., Kleber M.E., März W., de Boer I.H., Wood A.C., Rotter J.I., Rich S.S., Robinson-Cohen C., den Heijer M., Jarvelin M.R., Cavadino A., Joshi P.K., Wilson J.F., Hayward C., Lind L., Michaëlsson K., Trompet S., Zillikens M.C., Uitterlinden A.G., Rivadeneira F., Broer L., Zgaga L., Campbell H., Theodoratou E., Farrington S.M., Timofeeva M., Dunlop M.G., Valdes A.M., Tikkanen E., Lehtimäki T., Lyytikäinen L.P., Kähönen M., Raitakari O.T., Mikkilä V., Ikram M.A., Sattar N., Jukema J.W., Wareham N.J., Langenberg C., Forouhi N.G., Gundersen T.E., Khaw K.T., Butterworth A.S., Danesh J., Spector T., Wang T.J., Hyppönen E., Kraft P, & Kiel D.P. (2018). Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Nature Communications, 9, 260.
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Publication 2018
Biological Assay Calcifediol Genome Index, Body Mass Phenotype Reproduction Specimen Collection
2
German Health Examination Survey
DEGS1 aims to analyze health status, health risks and resources, functional capacity levels, and disability in the German adult population. Prevalence estimates will be obtained and time trends will be analyzed in comparison with data from the GNHIES98. Changes in health status and risk factors over time at the individual level will be studied among DEGS1 participants who already took part in the GNHIES98. Major study objectives include:
(1) To estimate the prevalence of diseases and risk factors with high public health impact and to identify differences according to socio-demographic characteristics, region of residence as well as changes over time;
(2) To analyze data on medication use and health care services utilization with regard to aspects of treatment effectiveness and quality of care;
(3) To investigate the association between mental health, physical health, and health-related behavior;
(4) To study patterns and determinants of co- and multimorbidity in the population 65 years and older in association with functional capacity levels, disability and health-related quality of life;
(5) To analyze allergic sensitization patterns and associations with manifest allergic disease in the population;
(6) To assess nutritional health risks and states of nutritional deficiency based on semiquantitative assessment of dietary habits and serum concentrations of various micronutrients (25-hydroxyvitamin D, vitamin B 12, iron, and ferritin in serum; serum and erythrocyte folate; urinary sodium excretion);
(7) To estimate iodine intake at the population level based on urinary iodine excretion;
(8) To examine individual changes in health status and cardiometabolic risk factors (e. g. body mass index; glycosylated hemoglobin A1c, serum lipids) over time.
Scheidt-Nave C., Kamtsiuris P., Gößwald A., Hölling H., Lange M., Busch M.A., Dahm S., Dölle R., Ellert U., Fuchs J., Hapke U., Heidemann C., Knopf H., Laussmann D., Mensink G.B., Neuhauser H., Richter A., Sass A.C., Rosario A.S., Stolzenberg H., Thamm M, & Kurth B.M. (2012). German health interview and examination survey for adults (DEGS) - design, objectives and implementation of the first data collection wave. BMC Public Health, 12, 730.
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Publication 2012
Adult Calcifediol Cobalamins Disabled Persons Erythrocytes Ferritin Folate Glycated Hemoglobin A1c Hypersensitivity Index, Body Mass Iodine Iron Lipids Malnutrition Micronutrients Patient Acceptance of Health Care Pharmaceutical Preparations Physical Examination Quality of Health Care Serum Sodium Urine
3
Serum Biomarkers of Vitamin D Metabolism
Baseline blood samples were frozen at −80°C and stored for later analysis. 25(OH)D, serum calcium, albumin, and levels of parathyroid hormone (PTH) were measured in the Massachusetts General Hospital (MGH) clinical laboratories. 25(OH)D2 and 25(OH)D3 levels were measured by liquid chromatography–tandem mass spectrometry (LC-MS), with interassay coefficients of variation (CVs) of 9.1% for 25(OH)D2 and 8.6% for 25(OH)D3. Total 25(OH)D level was calculated as the sum of 25(OH)D2 level and 25(OH)D3 level. Intact PTH was measured by electrochemiluminescense immunoassay on the Cobas E160 automated analyzer (Roche Diagnostics, Indianapolis, IN, USA). The interassay CV for intact PTH measurement was 4.2%. Calcium and albumin levels were measured by dye-based photometric assays on an automated analyzer.
DBP was measured in duplicate by commercial enzyme-linked immunosorbent assay (ELISA; Cat. No. DVDBP0, R&D Systems, Minneapolis, MN, USA) according to the manufacturer's instructions. The assay was conducted after diluting serum samples 1:2000 in Calibrator Diluent RD6-11 (Part No. 895489, R&D Systems). The interassay CV was 8.5% at a concentration of 40 µg/mL. The assay recovered between 93% and 110% of a 100- to 200-µg/mL dose of exogenous DBP added to human serum samples containing between 25 and 200 µg/mL of endogenous DBP. The manufacturer reports no significant cross-reactivity with human albumin, vitamin D3, or α-fetoprotein.
In a subset of patients in whom adequate serum was available (n = 45), total 1,25(OH)2D3 was measured by LC-MS/MS in the Mayo Clinic Medical Laboratories (Rochester, MN, USA).
Powe C.E., Ricciardi C., Berg A.H., Erdenesanaa D., Collerone G., Ankers E., Wenger J., Karumanchi S.A., Thadhani R, & Bhan I. (2011). Vitamin D–Binding Protein Modifies the Vitamin D–Bone Mineral Density Relationship. Journal of Bone and Mineral Research, 26(7), 1609-1616.
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Publication 2011
Albumins alpha-Fetoproteins Biological Assay BLOOD Calcifediol Calcium Cholecalciferol Clinical Laboratory Services Cross Reactions Diagnosis Enzyme-Linked Immunosorbent Assay Freezing Homo sapiens Immunoassay Liquid Chromatography Parathyroid Hormone Patients Photometry Serum Serum Albumin, Human Tandem Mass Spectrometry
4
Replicating Novel Vitamin D Loci
We replicated the identified novel loci in two independent data sets for which genotype data were available: the European Prospective Investigation into Cancer and Nutrition (EPIC) study with 40,562 individuals across two nested case-control studies (EPIC-InterAct and EPIC-CVD) and the cohort-wide EPIC-Norfolk study (Supplementary Note 1); and a cohort of 2195 individuals (all controls) additionally collected as part of the SOCCS that were not included in our discovery stage. As for the phenotype, EPIC individuals were assayed for plasma 25-hydroxyvitamin D3 and SOCCS individuals were assayed for total 25-hydroxyvitamin D. We performed the association analysis in a similar manner, adjusted for age, sex, time of sample collection, and study center where relevant. We regarded P-value < 0.05 in the replication samples, and P-value < 5×10−8 in the pooled analysis as successful replication.
Jiang X., O’Reilly P.F., Aschard H., Hsu Y.H., Richards J.B., Dupuis J., Ingelsson E., Karasik D., Pilz S., Berry D., Kestenbaum B., Zheng J., Luan J., Sofianopoulou E., Streeten E.A., Albanes D., Lutsey P.L., Yao L., Tang W., Econs M.J., Wallaschofski H., Völzke H., Zhou A., Power C., McCarthy M.I., Michos E.D., Boerwinkle E., Weinstein S.J., Freedman N.D., Huang W.Y., Van Schoor N.M., van der Velde N., Groot L.C., Enneman A., Cupples L.A., Booth S.L., Vasan R.S., Liu C.T., Zhou Y., Ripatti S., Ohlsson C., Vandenput L., Lorentzon M., Eriksson J.G., Shea M.K., Houston D.K., Kritchevsky S.B., Liu Y., Lohman K.K., Ferrucci L., Peacock M., Gieger C., Beekman M., Slagboom E., Deelen J., Heemst D.V., Kleber M.E., März W., de Boer I.H., Wood A.C., Rotter J.I., Rich S.S., Robinson-Cohen C., den Heijer M., Jarvelin M.R., Cavadino A., Joshi P.K., Wilson J.F., Hayward C., Lind L., Michaëlsson K., Trompet S., Zillikens M.C., Uitterlinden A.G., Rivadeneira F., Broer L., Zgaga L., Campbell H., Theodoratou E., Farrington S.M., Timofeeva M., Dunlop M.G., Valdes A.M., Tikkanen E., Lehtimäki T., Lyytikäinen L.P., Kähönen M., Raitakari O.T., Mikkilä V., Ikram M.A., Sattar N., Jukema J.W., Wareham N.J., Langenberg C., Forouhi N.G., Gundersen T.E., Khaw K.T., Butterworth A.S., Danesh J., Spector T., Wang T.J., Hyppönen E., Kraft P, & Kiel D.P. (2018). Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Nature Communications, 9, 260.
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Publication 2018
Calcifediol DNA Replication Europeans Genotype Malignant Neoplasms Nutrition Assessment Phenotype Plasma Specimen Collection
5
Measuring Vitamin D and Related Biomarkers
Blood samples drawn at the examination were stored at −80°C. Levels of total 25-hydroxyvitamin D (D2 and D3) were measured with the use of tandem mass spectrometry (interassay coefficient of variation, 8.6%). Levels of vitamin D– binding protein were measured by means of a commercial enzyme-linked immunosorbent assay (R&D Systems) that uses two monoclonal antibodies in a sandwich format (interassay coefficient of variation, 7.2%). Levels of intact parathyroid hormone were measured with the use of the Elecsys Parathyroid Hormone Immunoassay (Modular Analytics E170, Roche Diagnostics) (interassay coefficient of variation, 2.5%). Calcium levels were corrected for the participant's albumin level as follows: corrected calcium = (measured calcium in mg per deciliter) + [0.8 × (4.0 − serum albumin in g per deciliter)].
Powe C.E., Evans M.K., Wenger J., Zonderman A.B., Berg A.H., Nalls M., Tamez H., Zhang D., Bhan I., Karumanchi S.A., Powe N.R, & Thadhani R. (2013). Vitamin D–Binding Protein and Vitamin D Status of Black Americans and White Americans. The New England journal of medicine, 369(21), 1991-2000.
Publication 2013
Albumins BLOOD Calcifediol Calcium Diagnosis Enzyme-Linked Immunosorbent Assay Immunoassay Monoclonal Antibodies Parathyroid Hormone Serum Albumin Tandem Mass Spectrometry Vitamin D-Binding Protein

Most recents protocols related to «Calcifediol»

1
Comprehensive Clinical Biomarker Assessment
On the first day of ICU admission, patients’ medical records were assessed to obtain data on fasting blood sugar (FBS, mg/dL), serum levels of inflammatory biomarkers [C-reactive protein (CRP, mg/L) and interleukin-6 (IL-6, pg./mL)], albumin (g/dL), creatinine (mg/dL), urea (mg/dL), bilirubin (mg/dL), and 25-hydroxy vitamin D3 [25(OH)D3, ng/mL]. Serum levels of electrolytes including magnesium (mEq/L), phosphorous (mg/dL), calcium (mg/dL), sodium (mEq/L), and potassium (mEq/L) were also assessed. We also collected data on hematological factors including white blood cells (neutrophil and lymphocyte, 103/μL), hematocrit (%), and platelet (103/μL).
Gholi Z., Vahdat Shariatpanahi Z., Yadegarynia D, & Eini-Zinab H. (2023). Associations of body mass index with severe outcomes of COVID-19 among critically ill elderly patients: A prospective study. Frontiers in Nutrition, 10, 993292.
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Publication 2023
Albumins Bilirubin Blood Glucose Blood Platelets Calcifediol Calcium, Dietary Cholecalciferol C Reactive Protein Creatinine Electrolytes Inflammation Leukocytes Lymphocyte Magnesium Neutrophil Patients Phosphorus Potassium Serum Sodium Urea Volumes, Packed Erythrocyte
2
Blood Biomarkers of Elite Athletes
All subjects had a single blood sample taken in the morning. Blood sampling was carried out in one day in August 2021 between 8:00 and 10:00 a.m. from the cubital vein by an experienced technician. All athletes were instructed to rest on the day prior to blood sampling and refrain from alcohol consumption. Analysis of total 25-hydroxyvitamin D (25-OHVITD) in the blood were performed by liquid chromatography-mass spectrometry (LC–MS) on an Agilent 1200 liquid chromatography (Agilent, USA) combined with an AB Sciex 3200 MD mass detector (Sciex, USA). 25 (OH) D concentration was measured using total 25-hydroxyvitamin D levels (25-OHVITD), which is currently considered the most appropriate to reflect vitamin D stores in the body [39 (link), 40 (link)]. Vitamin D bio-chemical marker 25 (OH) D values above 30 ng/ml were considered normal, 20-30 ng/ml were considered insufficient, and below 20 ng/ml were considered deficient [14 (link)]. Analysis of total testosterone in the blood were performed by liquid chromatography-mass spectrometry (LC–MS) on an Agilent 1200 liquid chromatography (Agilent, USA) combined with an AB Sciex 3200 MD mass detector (Sciex, USA). The separation of substances was conducted in a gradient mode, where an acetate buffer was used during the aqueous phase, and methanol was utilized during the organic phase. A reverse-phase column (Phenomenex, USA) was used during the stationary phase. All reagents used were labeled no lower than HPLC-grad, considering the standards for substances produced by TRC (Canada). These procedures have been previously validated and are based on published guidelines for obtaining the most valid, reliable and accurate testosterone values [41 , 42 ].
Bezuglov E., Shoshorina M., Lazarev A., Emanov A., Koroleva E., Anishchenko I., Waśkiewicz‬ Z., Butovskiy M, & Morgans R. (2023). Does vitamin D affect strength and speed characteristics and testosterone concentration in elite young track and field athletes in the North European summer?. Nutrition Journal, 22, 16.
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Publication 2023
Acetate Athletes BLOOD Buffers Calcifediol Ergocalciferol High-Performance Liquid Chromatographies Human Body Liquid Chromatography Mass Spectrometry Methanol Testosterone Veins
3
Quantitative Serum 25(OH)D3 Analysis
The content of 25- hydroxyvitamin D3 [25(OH)D3] in the serum was detected by high-performance liquid chromatography (tandem mass spectrometry). An isotopic internal standard was added to 10 microliter serum samples. The protein in samples was precipitated with anhydrous ethanol and the target chemicals were extracted using n-hexane. After extraction, the supernatants were evaporated to dryness under a stream of nitrogen. The residue underwent the derivation process and the derivatizing products were redissolved and chromatographically separated and quantified by mass spectrometry. The liquid chromatographic column was InfinityLab Poroshell 120 EC-C18 (4.6 mm × 50 mm, 2.7 µm), C18 guard column (Phenomenex, USA). The LC-20AD liquid chromatography-API 3200MD triple quadrupole mass spectrometer (Shimadzu, AB Sciex, USA) with an automatic injector was used.
Li L., Cui X., Zhang X., Zheng L., Sun X., Yang C., Shu J, & Liu G. (2023). Serum vitamin D3 deficiency can affect the efficacy of sublingual immunotherapy in children with allergic rhinitis: a retrospective cohort study. Journal of Thoracic Disease, 15(2), 649-657.
Publication 2023
Absolute Alcohol Calcifediol High-Performance Liquid Chromatographies Isotopes Liquid Chromatography Mass Spectrometry n-hexane Nitrogen Proteins Serum Tandem Mass Spectrometry
4
COVID-19 Cohort Study in Iran
The current study comprised 3,184 patients with a diagnosis of COVID-19 who were referred to a teaching hospital of Ilam University of Medical Sciences, Ilam, Iran, within November 2020 to February 2022, including 1,734 recovered and 1450 deceased patients. A COVID-19 infection was deemed for all patients as a result of a positive SARS-CoV-2 laboratory test with real-time reverse transcription polymerase chain reaction (rtReal time-PCR) from the nasopharyngeal swabs. Peripheral blood samples from each patient were taken to isolate deoxyribonucleic acid (DNA) and conduct additional genetic studies.
The samples were collected in the three peaks (Alpha, Delta, and Omicron BA.5) from 14,472 positive patients based on the inclusion criteria, namely (1) patients who were willing to participate in the study and had signed a written consent form, (2) all patients who were Iranian with one ethnicity, and (3) patients who did not have any underlying comorbidities diseases, such as kidney, heart, and pulmonary diseases, hypertension, diabetes, obesity, cancer, viral infections (e.g., human immunodeficiency virus and hepatitis B and C viruses), and pregnancy.
All clinical data of patients such as real-time PCR cycle threshold (Ct) values, 25-hydroxyvitamin D, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), complete blood count (CBC), lipid profile (cholesterol, high density lipoprotein, and low density lipoprotein), liver enzymes (aspartate aminotransferase, alkaline phosphatase, and alanine aminotransferase), creatinine and uric acid were extracted from patient files, and these tests were performed when the patient entered the hospital.
According to the World Health Organization guidelines, adult COVID-19 patients were divided into three clinical course categories, mild, moderate, and severe. In this study, subjects with mild/moderate and severe/critical symptoms were considered recovered and deceased patients, respectively.
Patients with mild symptoms include those who have a fever, fatigue, cough, headache, myalgia, and fatigue but do not have dyspnea or pneumonia; patients with moderate symptoms include those who have blood oxygen saturation levels above 93% on room air and evidence of pneumonia based on imaging showing up to 50% lung involvement; patients with severe symptoms include those who have blood oxygen saturation levels below 93% on room air and need supportive oxygen therapy.
Abbood S.J., Anvari E, & Fateh A. (2023). Association between interleukin-10 gene polymorphisms (rs1800871, rs1800872, and rs1800896) and severity of infection in different SARS-CoV-2 variants. Human Genomics, 17, 19.
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Publication 2023
Adult Alkaline Phosphatase As-A 2 Aspartate Transaminase Birth BLOOD Blood Oxygen Levels Calcifediol Cholesterol Cough COVID 19 C Reactive Protein Creatinine D-Alanine Transaminase Diabetes Mellitus Diagnosis DNA Dyspnea Enzymes Ethnicity Fatigue Fever Headache Heart Hepatitis B High Blood Pressures High Density Lipoproteins HIV Kidney Lipids Liver Low-Density Lipoproteins Lung Lung Diseases Malignant Neoplasms Myalgia Nasopharynx Obesity Patients Pneumonia Pregnancy Real-Time Polymerase Chain Reaction Reverse Transcription Sedimentation Rates, Erythrocyte Severe acute respiratory syndrome-related coronavirus Therapies, Oxygen Inhalation Uric Acid Virus Virus Diseases
5
Comprehensive Evaluation of Bone and Muscle Health
Biochemical indices including complete blood count; levels of serum calcium (Ca), phosphonium (P), and alkaline phosphatase (ALP); liver and kidney functions; and levels of creatine kinase (CK) and its MB isoenzyme (CK-MB), 25-hydroxyvitamin D (25OHD), the intact parathyroid hormone (PTH) bone formation marker serum osteocalcin (OC), and the bone resorption marker serum beta cross-linked C-terminal telopeptide of type 1 collagen (β-CTX) were measured. Measurements of bone mineral density (BMD) of the lumbar spine and left femur neck were performed by dual-energy X-ray absorptiometry (Lunar iDXA, GE Healthcare, Madison, WI, USA). The results were transformed into age- and sex-specific Z-scores using reference data [13 (link)]. X-ray radiographs of thoracic and lumbar vertebrae, hips, knees, and ankles were obtained. The left leg muscle was examined by magnetic resonance imaging (MRI). Electromyography was performed and nerve conduction was analysed.
Mei Y., Jiang Y., Zhang Z, & Zhang H. (2023). Muscle and bone characteristics of a Chinese family with spinal muscular atrophy, lower extremity predominant 1 (SMALED1) caused by a novel missense DYNC1H1 mutation. BMC Medical Genomics, 16, 47.
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Publication 2023
Alkaline Phosphatase Ankle Bone Density Bone Resorption Calcifediol Calcium, Dietary Complete Blood Count Coxa Creatine Kinase Dual-Energy X-Ray Absorptiometry Electromyography ICTP peptide Isoenzyme CPK MB Isoenzymes Kidney Knee Liver Muscle Tissue Neck, Femur Nerve Conduction Osteocalcin Osteogenesis Parathyroid Hormone Radiography Radiography, Thoracic Serum Silver Vertebrae, Lumbar

Top products related to «Calcifediol»

1
Cobas e411 by Roche
Sourced in Germany, Switzerland, United States, Japan, United Kingdom, Denmark, France, Poland
The Cobas e411 is a compact and fully automated immunoassay analyzer designed for clinical laboratory settings. It is capable of performing a wide range of immunoassay tests, including those for hormones, therapeutic drug monitoring, and infectious disease markers. The Cobas e411 is known for its reliability, ease of use, and efficient throughput.
2
25 hydroxy vitamin d 125i ria kit by DiaSorin
Sourced in United States, Finland
The 25-hydroxy-vitamin D 125I RIA Kit is a radioimmunoassay (RIA) product used for the quantitative determination of 25-hydroxy-vitamin D levels in human serum or plasma samples. The kit utilizes iodine-125 (125I) as the radioactive tracer for the competitive binding process. The core function of this kit is to provide a reliable and accurate measurement of 25-hydroxy-vitamin D concentrations.
3
Cobas e601 by Roche
Sourced in Germany, Switzerland, United States, China, Sweden, United Kingdom, Japan, Canada
The Cobas e601 is an automated immunochemistry analyzer used for in vitro diagnostic testing. It is designed to perform a wide range of immunoassay tests, including those for hormones, tumor markers, and infectious diseases. The Cobas e601 utilizes electrochemiluminescence technology to provide accurate and reliable results.
4
1470 wizard gamma counter by PerkinElmer
Sourced in Finland, United States, Belgium
The 1470 Wizard Gamma Counter is a laboratory instrument used for the measurement and analysis of gamma radiation. It is designed to provide accurate and reliable results for various applications involving the detection and quantification of gamma-emitting isotopes.
5
Liaison 25 oh vitamin d total assay by DiaSorin
Sourced in Italy, United States
The LIAISON® 25 OH Vitamin D TOTAL Assay is a laboratory equipment product developed by DiaSorin. The core function of this assay is to quantitatively determine the total 25-hydroxyvitamin D concentration in human serum and plasma samples.
6
Cobas 6000 by Roche
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The Cobas 6000 is an automated clinical chemistry and immunoassay analyzer system designed for high-volume laboratory testing. It combines the features of two separate instruments, the Cobas c 501 module for clinical chemistry and the Cobas e 601 module for immunoassays, into a single integrated platform. The Cobas 6000 system is capable of performing a wide range of diagnostic tests, including biochemical, immunological, and specialty assays.
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SAS 9.4 is an integrated software suite for advanced analytics, data management, and business intelligence. It provides a comprehensive platform for data analysis, modeling, and reporting. SAS 9.4 offers a wide range of capabilities, including data manipulation, statistical analysis, predictive modeling, and visual data exploration.
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The Immulite 2000 is an automated immunoassay analyzer designed for in vitro diagnostic testing. It is capable of performing a variety of immunoassay tests, including those for hormones, proteins, and other analytes. The system utilizes chemiluminescent technology for detection and provides automated sample handling, reagent management, and result reporting.
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The Radioimmunoassay (RIA) kit is a laboratory equipment used for the quantitative determination of analytes in biological samples. It employs the principles of radioimmunoassay technology to measure the concentration of target molecules. The kit provides the necessary reagents and materials to perform the RIA analysis.

More about "Calcifediol"

Calcifediol, also known as 25-hydroxyvitamin D or 25(OH)D, is a crucial prohormone in the vitamin D metabolic pathway.
It is produced in the liver when the body converts vitamin D3 (cholecalciferol) or vitamin D2 (ergocalciferol) into a more potent form.
Calcifediol plays a vital role in regulating calcium and phosphate homeostasis, which is essential for maintaining bone health and immune function.
Optimizing calcifediol research can be achieved through the use of PubCompare.ai, an AI-powered tool that enhances reproducibility and accuracy.
This platform allows researchers to easily locate relevant protocols from literature, preprints, and patents, and use AI-driven comparisons to identify the best protocols and products for their calcifediol studies.
Calcifediol levels can be measured using various analytical techniques, such as the Cobas e411 and Cobas e601 electrochemiluminescence immunoassays, the 25-hydroxy-vitamin D 125I RIA Kit, the LIAISON® 25 OH Vitamin D TOTAL Assay, and the Immulite 2000 chemiluminescent immunoassay.
These methods provide accurate and reliable quantification of serum or plasma 25(OH)D concentrations, which are crucial for assessing vitamin D status and monitoring treatment.
In addition to these laboratory techniques, researchers can utilize statistical analysis software, such as SAS 9.4, to perform advanced data analysis and interpretation of calcifediol-related studies.
The 1470 Wizard Gamma Counter can also be employed for radioimmune assays (RIA) to measure 25(OH)D levels.
By leveraging the capabilities of PubCompare.ai and these analytical tools, researchers can streamline their calcifediol studies, enhance reproducibility, and gain valuable insights to advance their understanding of vitamin D metabolism and its impact on human health.