The OBS had combined the contributions of both diet and lifestyle. To investigate whether diet or lifestyle factors significantly contributed to the OBS-LTL association, respectively, we calculated a dietary OBS by excluding four lifestyle variables: cotinine, alcohol consumption, BMI, and physical activity from the OBS measures that have been described above and calculated a lifestyle OBS that only included these four variables [52 (link)].
Vitamin B6
It is involved in protein metabolism, red blood cell formation, and neurotransmitter synthesis.
Vitamin B6 deficiency can lead to a range of health issues, including anemia, nerve damage, and impaired immune function.
Researchers studying Vitamin B6 can utilize the PubCompare.ai platform to optimize their research by locating the best protocols and produts from literature, pre-prints, and patents.
This AI-driven tool enhancs reproducibility and accuracy, providing valuable insights to advance Vitamin B6 studies.
With its advanced comparisons, PubCompare.ai helps researchers stay at the forefront of this important area of nutrition and health.
Most cited protocols related to «Vitamin B6»
The OBS had combined the contributions of both diet and lifestyle. To investigate whether diet or lifestyle factors significantly contributed to the OBS-LTL association, respectively, we calculated a dietary OBS by excluding four lifestyle variables: cotinine, alcohol consumption, BMI, and physical activity from the OBS measures that have been described above and calculated a lifestyle OBS that only included these four variables [52 (link)].
Prior to conversion into final simulation files, the network was tested for elemental and charge balances using the COBRA toolbox [30] (link) and the toolbox SubLiminal [68] (link). In case of unclear specificity of a reaction for NAD/NADH or NADP/NADPH, only the latter was included. Within the section ‘Metabolic flux during periods of darkness’, the glutamate dehydrogenase (GDH) reaction was assumed to be irreversible to avoid metabolic cycles that compensate for the lack of the transhydrogenase. The reconstructed network file (Supplemental Dataset S1) is compliant with MIRIAM. When available, all metabolites are referenced by their corresponding CheEBI ID [69] (link). We note that the intracellular pH of Synechocystis sp. PCC 6803 changes under diurnal conditions, from approx to
[70] (link). For simplicity, we use the values as a reference condition. The network file used for simulation with the COBRA toolbox is included as Supplemental Dataset S2.
Using the R program (v 3.0.2), a system and an environment for the statistical computation [82 (link),83 (link),84 (link)], particularly, the action commands on arrays, matrices and vectors, the energy value and the nutrient content were calculated for the consumption of each of the 38,886 households (n = 99,230). Statistical calculations were performed with the weight of corrections to improve the representativeness of the results and the size of the household. This allowed us to recognize the results as representative for the population of Poland [77 ,85 (link)].
For the purpose of this study, the mean and the standard errors of energy were calculated for 7 food groups and 16 food products from the meats and the seafood categories. The mean nutrient intake was expressed as a percentage of the total dietary intake of the analyzed nutrient and presented in a ranked order. A two-stage method of presenting the results was adopted:
the most important data related to the share of main food groups in contribution of energy and 22 nutrients intake presented in
the detailed data related to the share of 7 food products and 16 food products in contribution of energy and 22 nutrients intake presented in Supplement Tables.
Most recents protocols related to «Vitamin B6»
Example 2
100 mg of the Sarcodon aspratus extracts according to the present invention;
an appropriate amount of a vitamin mixture;
70 μg of vitamin A acetate;
1.0 mg of vitamin E;
0.13 mg of vitamin B1;
0.15 mg of vitamin B2;
0.5 mg of vitamin B6;
0.2 μg of vitamin B12;
10 mg of vitamin C;
10 μg of biotin;
1.7 mg of nicotinic acid amide;
50 μg of folate;
0.5 mg of calcium pantothenate;
an appropriate amount of a mineral mixture;
1.75 mg of ferrous sulfide;
0.82 mg of zinc oxide;
25.3 mg of magnesium carbonate;
15 mg of potassium phosphate monobasic;
55 mg of dicalcium phosphate;
90 mg of potassium citrate;
100 mg of calcium carbonate; and
24.8 mg of magnesium chloride.
The composition ratio of the vitamins and the mineral mixture described above may be determined according to a composition ratio used in general functional health foods, and the combination ratio of the vitamins and the mineral mixture may be arbitrarily determined. According to a conventional method of preparing functional health foods, these components are mixed, granules are prepared, and the granules are used to prepare a composition for a functional health food.
Example 6
This example provides a representative example of an aqueous solution to be used in a method described herein. The composition may contain the following ingredients:
The aqueous solution is formulated in physiological saline and adjusted to about pH 7.4, thereby minimizing any injecting pain beyond the needle prick. In addition, the aqueous solution may be optionally supplemented with a preservative (e.g., benzyl alcohol), a chemical stabilizer (e.g., gentisic acid), and/or an additional bioactive agent (e.g., platelet-rich plasma) depending on anticipated delivery method, shelf-life, and intended effects.
Example 7
The purpose of this example is to evaluate the efficacy of a composition described herein in treating the signs of aging present on facial skin. A composition is prepared as in Example 6.
Two groups of human subjects (8-10 subjects per group) are injected with the composition or physiological saline (control) twice a day for a period of 29 days. At the end of the 29 day test period, the subjects are polled regarding various aspects of the effectiveness of the composition described herein in treating and/or minimizing signs of aging present on the skin. The following aspects of the composition described herein are evaluated:
-
- (1) effectiveness of the composition described herein in improving the smoothness and/or softness of skin (i.e., making the skin feel smoother and softer following treatment);
- (2) effectiveness of the composition described herein in improving the overall appearance of skin;
- (3) effectiveness of the composition described herein in evening out skin tone and texture;
- (4) effectiveness of the composition described herein in improving the clarity and/or radiance of skin;
- (5) effectiveness of the composition described herein in making the skin look younger; and
- (6) effectiveness of the composition described herein in making wrinkles appear softer and/or less prominent.
- (7) effectiveness of the composition described herein in increasing the degree of hydration of the skin.
Patients treated with the composition exhibit improvement in one or more of the symptoms described herein.
Example 8
The purpose of this example is to evaluate the efficacy of a composition described herein in treating the signs of aging present on facial skin. A composition is prepared as in Example 6.
Two groups of human subjects (8-10 subjects per group) are injected with the composition or physiological saline (control) on days 1, 3, 7, 10, 14, 21, 30, 60, and 90 of treatment. At the end of the 90-day test period, the subjects are polled regarding various aspects of the effectiveness of the composition described herein in treating and/or minimizing signs of aging present on the skin. The following aspects of the composition described herein are evaluated:
-
- (1) effectiveness of the composition described herein in improving the smoothness and/or softness of skin (i.e., making the skin feel smoother and softer following treatment);
- (2) effectiveness of the composition described herein in improving the overall appearance of skin;
- (3) effectiveness of the composition described herein in evening out skin tone and texture;
- (4) effectiveness of the composition described herein in improving the clarity and/or radiance of skin;
- (5) effectiveness of the composition described herein in making the skin look younger; and
- (6) effectiveness of the composition described herein in making wrinkles appear softer and/or less prominent.
- (7) effectiveness of the composition described herein in increasing the degree of hydration of the skin.
Patients treated with the composition exhibit improvement in one or more of the symptoms described herein.
While preferred embodiments have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only. Numerous variations, changes, and substitutions will now occur to those skilled in the art without departing from the embodiments. It should be understood that various alternatives to the embodiments described herein may be employed. It is intended that the following claims define the scope of the embodiments and that methods and structures within the scope of these claims and their equivalents be covered thereby.
Example 5
An aqueous solution containing the following ingredients:
-
- about 1500 to about 6250 meg cobalamin (vitamin B12);
- about 150 to about 250 mg ascorbic acid (vitamin C);
- about 30 to about 50 mg nicotinamide (vitamin B3);
- about 4.5 to about 7.5 mg thiamine (vitamin B1);
- about 0.1 to about 0.3 mg pyridoxine HCl (vitamin B6);
- about 2.7 to about 4.5 mg riboflavin 5-phosphate sodium (vitamin B2);
- about 7.5 to about 15 mg pantothenic acid (vitamin B5);
- about 0.08 to about 0.125 mg Zinc sulfate heptahydrate; and
- about 1 ml q.s., sterile water for injection
The aqueous solution is formulated in physiological saline and adjusted an acceptable pH in the range of about 6.5 to about 7.5 to 7.4, thereby minimizing any injecting pain beyond the needle prick. The aqueous solution may be optionally supplemented with a preservative (e.g., from about 0.01% to about 2% benzyl alcohol), a chemical stabilizer (e.g., from about 0.01% to about 2% gentisic acid), and/or an additional bioactive agent (e.g., from about 0.01% to about 2% hyaluronic acid) depending on anticipated delivery method, shelf-life, and intended effects.
Example 1
An aqueous solution containing the following ingredients:
-
- about 500 to about 1500 mcg cobalamin (vitamin B12);
- about 100 to about 200 mg ascorbic acid (vitamin C);
- about 10 to about 60 mg nicotinamide (vitamin B3);
- about 2 to about 10 mg thiamine (vitamin B1);
- about 2 to about 10 mg pyridoxine HCl (vitamin B6);
- about 2 to about 10 mg riboflavin 5-phosphate sodium (vitamin B2);
- about 0.5 to about 1.5 mg zinc
- about 1 ml q.s., sterile water for injection
The aqueous solution is formulated in physiological saline and adjusted an acceptable pH in the range of about 6.5 to about 7.5 to 7.4, thereby minimizing any injecting pain beyond the needle prick. The aqueous solution may be optionally supplemented with a preservative (e.g., from about 0.01% to about 2% benzyl alcohol) and/or a chemical stabilizer (e.g., from about 0.01% to about 2% gentisic acid), depending on anticipated shelf-life.
The protein content, fat content, reducing sugar content, mineral elements, vitamin B1, vitamin B2, vitamin B6 were determined according to the Chinese National Standard Method GB5009.5-2016, GB5009.6-2016, GB5009.7-2016, GB5009.268-2016, GB5009.84-2016, GB5009.85-2016, GB5009.154-2016, respectively (24 –30 ). The free amino acids content was determined according to the method of Li et al. (31 (link)). The specific test methods are described in the
Top products related to «Vitamin B6»
More about "Vitamin B6"
It is involved in protein metabolism, red blood cell formation, and neurotransmitter synthesis.
Pyridoxine deficiency can lead to a range of health issues, including anemia, nerve damage, and impaired immune function.
Researchers studying Vitamin B6 can utilize the PubCompare.ai platform to optimize their research by locating the best protocols and products from literature, pre-prints, and patents.
This AI-driven tool enhances reproducibility and accuracy, providing valuable insights to advance Vitamin B6 studies.
With its advanced comparisons, PubCompare.ai helps researchers stay at the forefront of this important area of nutrition and health.
The PubCompare.ai platform can also be used to explore related topics, such as Riboflavin (Vitamin B2), Acetonitrile, and Pyridoxine hydrochloride.
Researchers can use the platform to compare different methods and products, including the use of Sodium hydroxide, Methanol, and Formic acid in Vitamin B6 research.
The platform's advanced analytics can also provide insights into the use of C57BL/6J mice and the role of Ascorbic acid (Vitamin C) in Vitamin B6 studies.
By utilizing PubCompare.ai, researchers can enhance the reproducibility and accuracy of their Vitamin B6 studies, leading to advancements in our understanding of this essential nutrient and its impact on human health.