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Microspheres

Microspheres are small, spherical particles typically ranging from 1 to 1,000 micrometers in diameter.
They are used in a variety of applications, including drug delivery, tissue engineering, and diagnostic imaging.
Microspheres can be made from a variety of materials, such as polymers, ceramics, or metals, and can be designed to have specific properties, such as controlled release of encapsulated compounds or targeted delivery to specific tissues or cells.
Researchers studying microspheres can utilize the PubCompare.ai platform to locate relevant protocols from the literature, preprints, and patents, as well as leverage AI-driven comparisons to identify the best protocols and poducts.
This can help improve reproducibility and accuracy in microspheres research.

Most cited protocols related to «Microspheres»

1
Multispecies Live-Cell Imaging and Analysis
C. crescentus, B. subtilis, A. biprosthecum, Rhodomicrobium sp, and P. hirshii were grown in PYE14 (link) at 30°C. A. tumefaciens, S. venezuelae, L. lactis, were grown in LB15 (link) at 30°C and E. coli was grown in LB15 (link) at 37°C. M. xanthus were grown at 32°C in CYE16 (link). S. pneumonia were grown at 37°C in THY17 . Rhodopseudomonas palustris CGA009 was grown anaerobically in defined mineral medium (PM)18 supplemented with 10 mM succinate and incubated at 30°C with constant illumination from a 60 W incandescent light bulb.
Phase and fluorescence time-lapse imaging was performed on a Nikon Ti-E inverted microscope, equipped with a Plan Apo 60×, 1.40 NA, Oil, Ph3 DM objective and 1.5× magnifier. Images were acquired every 5 min, and fluorescent proteins were illuminated with a Lumencor Spectra × light engine equipped with excitation filters 470/24 (GFP), 510/25 (YFP) or 575/25 (mCherry), Chroma emission filters 510/40 (GFP), 545/30 (YFP), 530/60 (mCherry) and either a quad polychroic DAPI/FITC/Cy3/Cy5 or triple polychroic CFP/YFP/mCherry cube for Lumencor SpectraX. Images were acquired using an Andor iXon3 DU885 EM CCD camera driven by NIS Elements Advanced Research software (Nikon, Melville, NY)
Cultures from strain YB4667 CB15::pvan-ftsZ-yfp were grown in PYE medium at 30°C and induced for 2 hours with 0.5 mM vanillic acid to express FtsZ-YFP. Exponentially growing cells from this culture were spotted onto a 0.8 mm thick 1% agarose pad made with PYE medium containing 0.5 mM vanillic acid and timelapse images were acquired every 5 minutes from 16 different slide positions for 54 time points. For cell division inhibition, 30 µg/ml of cephalexin was added to the agarose pad during the imaging period.
For precision assessment of MicrobeJ, Molecular Probes FluoSpheres carboxylate-modified microspheres (F8823), 1± 0.0480 µm lot #1761288 were spotted onto a 1% agarose pad made with deionized water and images were acquired for 30 ms using the same microscope, camera and objective as cells.
Ducret A., Quardokus E.M, & Brun Y.V. (2016). MicrobeJ, a tool for high throughput bacterial cell detection and quantitative analysis. Nature microbiology, 1(7), 16077.
Publication 2016
Apolipoproteins A Cell Culture Techniques Cells Cephalexin DAPI Division, Cell Escherichia coli Fluorescein-5-isothiocyanate Fluorescence Incandescence Light Medulla Oblongata Microscopy Microspheres Minerals Molecular Probes Pneumonia Proteins Psychological Inhibition Rhodomicrobium Rhodopseudomonas palustris Sepharose Strains Succinate Vanillic Acid
2
Integrated Metabolomic and Functional Analysis of Prostate Cancer
Biospecimens and associated clinical data related to the study were collected with written consent from the University of Michigan and approved for use by the Internal Review Board. Unbiased metabolomic profiling using liquid/gas-chromatography coupled to mass spectrometry (LC/GC MS) was performed as described 3 (link) using a Thermofisher Linear Ion Trap mass spectrometer with Fourier Transform and Mat-95 XP mass spectrometers respectively (Supplementary Fig.1). Target metabolites were assessed in tissue and urine samples using isotope dilution GC-MS. Metabolomic data analysis is detailed in Supplementary Fig. 4. All Wilcoxon rank-sum tests and t-tests are two-sided using a threshold of P<0.05 for significance. Repeated measures ANOVA is used for the cell line data with p-values from the model F-test. Class-specific metabolomic patterns were visualized using Z-score plots and heat maps. Unsupervised clustering of samples using metabolomic signatures was performed using cluster13 (link) and tree view14 (link) and visualized using heat maps. Network relationship among various molecular concepts and metabolomic data was performed using Oncomine Concept Map4 (link),5 (link)(www.oncomine.org) as outlined in Supplementary Fig. 9. Invasion was measured using a modified Boyden Chamber assay as described10 (link). Cell motility assay was performed as previously reported using blue flourescent microsphere beads15 (link). Targeted knock-down of candidate genes 16 (link) using gene–specific siRNA sequences are listed in Supplementary Table 9. QPCR for enzymes regulating sarcosine levels, EZH2 and ETS were performed as described12 using indicated oligonucleotide primers (Supplementary Table 10). Chromatin immunoprecipitation to interrogate regulatory role of androgen and ETS was performed using published protocols17 (link). ChIP-Seq and digital gene expression were measured using the Genomic DNA sample prep kit and the NIaIII kit on a Genome Analyzer (Illumina) as per manufacturer’s instructions.
Full methods and any associated references are available in the online version of the paper at www.nature.com/nature.
Sreekumar A., Poisson L.M., Rajendiran T.M., Khan A.P., Cao Q., Yu J., Laxman B., Mehra R., Lonigro R.J., Li Y., Nyati M.K., Ahsan A., Kalyana-Sundaram S., Han B., Cao X., Byun J., Omenn G.S., Ghosh D., Pennathur S., Alexander D.C., Berger A., Shuster J.R., Wei J.T., Varambally S., Beecher C, & Chinnaiyan A.M. (2009). Metabolomic Profiles Delineate Potential Role for Sarcosine in Prostate Cancer Progression. Nature, 457(7231), 910-914.
Publication 2009
Androgens Biological Assay Cell Lines Cell Motility Assays Chromatin Immunoprecipitation Sequencing Enzymes EZH2 protein, human Fingers Gas Chromatography-Mass Spectrometry Gene Expression Gene Knockdown Techniques Genome Immunoprecipitation, Chromatin Isotopes Microspheres Microtubule-Associated Proteins microtubule associated protein 4 neuro-oncological ventral antigen 2, human Oligonucleotide Primers RNA, Small Interfering Sarcosine Technique, Dilution Tissues Trees Urine
3
Isolation and Differentiation of Human Myoblasts
Human myoblasts were isolated from biopsies and cultivated as described previously [19 (link)] in a growth medium consisting of 199 medium and DMEM (Invitrogen Carlsbad, CA) in a 1:4 ratio, supplemented with 20% FCS (Invitrogen), 2.5 ng/ml hepatocyte growth factor (Invitrogen), 0.1 μmol/l dexamethasone (Sigma-Aldrich, St. Louis, MO, USA) and 50 μg/ml gentamycin (Invitrogen). The myogenic purity of the populations was monitored by immunocytochemistry using desmin as marker. Enrichment of myogenic cells was performed using an immunomagnetic cell sorting system (MACS; Miltenyi Biotec, Paris, France) according to the manufacturer's instructions. Briefly, cells were labeled with anti-CD56 (a specific marker of myoblasts) microbeads, and then separated in a MACS column placed in a magnetic field. Purification was checked by immunochemistry using a desmin marker. Differentiation was induced at confluence by replacing the growth medium with DMEM supplemented with 100 μg/ml transferrin, 10 μg/ml insulin and 50 μg/ml of gentamycin (Sigma-Aldrich).
Mamchaoui K., Trollet C., Bigot A., Negroni E., Chaouch S., Wolff A., Kandalla P.K., Marie S., Di Santo J., St Guily J.L., Muntoni F., Kim J., Philippi S., Spuler S., Levy N., Blumen S.C., Voit T., Wright W.E., Aamiri A., Butler-Browne G, & Mouly V. (2011). Immortalized pathological human myoblasts: towards a universal tool for the study of neuromuscular disorders. Skeletal Muscle, 1, 34.
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Publication 2011
Biopsy Cells Culture Media Desmin Dexamethasone Gentamicin Hepatocyte Growth Factor Homo sapiens Immunocytochemistry Insulin Magnetic Fields Microspheres Myoblasts Myogenesis Population Group Transferrin
4
INNO-BIA AlzBio3 Immunoassay on Luminex Platform
The full details of the implementation of the INNO-BIA Alz Bio3 immunoassay reagents on the Luminex analytical platform are described elsewhere [29 (link), 42 ]. Monoclonal antibodies (mAbs) are used in this assay, and the production process for the immunoassay kits includes in current production processes assurance of lot-to-lot consistency. These tests are relative quantitative assays for CSF Aβ1–42, t-tau and p-tau181 since no international reference standards for the analytes prepared in CSF are available. Each participating center used the same INNO-BIA AlzBio3 immunoassay kit (assay lot # 157353 and calibrator lot # 157379), provided for the study by Innogenetics, Ghent, Belgium. The kit reagents include a mixture of three xMAP color-coded carboxylated microspheres, each containing a bead set coupled with well-characterized capture mAbs specific for Aβ1–42 (4D7A3; bead region 56), t-tau (AT120; bead region 2) or p-tau181 (AT270; bead region 69), and a vial with analyte-specific biotinylated detector mAbs (3D6 for Aβ1–42 and HT7 for t-tau or p-tau181). Ready-to-use vials containing pre-determined calibrator concentrations for the three analytes were provided. Calibration curves were produced for each biomarker using aqueous buffered solutions that contained the combination of three bio-markers at concentrations ranging from 56 to 1,948 pg/mL for recombinant t-tau, 27–1,574 pg/mL for synthetic Aβ1–42 and 8–230 pg/mL for a synthetic tau peptide phosphorylated at the threonine 181 position (the p-tau181 standard; numbering according to the longest tau isoforms [13 (link)]). In addition to the calibrators, the immunoassay kit includes two quality control samples, produced in aqueous diluent, with pre-defined acceptable concentration ranges for the three biomarkers.
Shaw L.M., Vanderstichele H., Knapik-Czajka M., Figurski M., Coart E., Blennow K., Soares H., Simon A.J., Lewczuk P., Dean R.A., Siemers E., Potter W., Lee V.M, & Trojanowski J.Q. (2011). Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI. Acta neuropathologica, 121(5), 597-609.
Publication 2011
Biological Assay Biological Markers Immunoassay Microspheres Monoclonal Antibodies Peptides Protein Isoforms Threonine
5
Single-Cell Transcriptome Profiling of Organs
Fresh, whole, and nontransplantable organs, or 1- to 2-cm3 organ samples, were obtained from surgery and then transported on ice by courier to tissue expert laboratories, where they were immediately prepared for transcriptome sequencing. Single-cell suspensions were prepared for 10× Genomics 3′ V3.1 droplet-based sequencing and for FACS-sorted 384-well plate smart-seq2. Preparation began with dissection, digestion with enzymes, and physical manipulation; tissue-specific details are available in the complete materials and methods (12 ). Cell suspensions from some organs were normalized by major cell compartment (epithelial, endothelial, immune, and stromal) using antibody-labeled magnetic microbeads to enrich rare cell types. cDNA and sequencing libraries were prepared and run on the Illumina NovaSeq 6000 with the goal to obtain 10,000 droplet-based cells and 1000 plate-based cells for each organ. Sequences were demultiplexed and aligned to the GRCh38 reference genome. Gene count tables were generated with CellRanger (droplet samples) or STAR and HTSEQ (plate samples). Cells with low unique molecular identifier (UMI) counts or low gene counts were removed. Droplet cells were filtered to remove barcode-hopping events and filtered for ambient RNA using DecontX. Sequencing batches were harmonized using scVI and projected to two-dimensional (2D) space with UMAP for analysis by the tissue experts. Expert annotation was made through the cellxgene browser and regularized with a public cell ontology. Annotation was manually QC checked and cross-validated with PopV, an annotation tool that uses seven different automated annotation methods. For complete materials and methods, see the supplementary materials (12 ).
The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. (2022). Science (New York, N.Y.), 376(6594), eabl4896.
Publication 2022
Cells Digestion Dissection DNA, Complementary Endothelium Enzymes Genes Genome Immunoglobulins Microspheres Operative Surgical Procedures Physical Examination Tissues Tissue Specificity

Most recents protocols related to «Microspheres»

1
Tretinoin Gel Formulation and Preparation
Not available on PMC !

Example 2

A composition comprising Tretinoin as an active ingredient:

IngredientsConcentration (w/w %)
Oleic acid4.00
Isopropanol6.00
BHT (Butylated Hydroxytoluene)0.02
Sorbic acid0.10
Tretinoin0.10
Silica microspheres0.70
Natrosol (HEC)1.50
Xanthan gum0.80
Trolamine1.20
Benzyl alcohol0.80
Glycerin15.00
Waterq.s. 100%

The process for the preparation of the composition was as follows:

    • 1. Trolamine, Natrosol (HEC) and xanthan gum were added gradually to the water while stirring at high speed using mixer propeller;
    • 2. The mixture of oleic acid, isopropanol, BHT, sorbic acid and tretinoin was heated to 50° C. while stirring then cooled to the room temperature;
    • 3. Silica microspheres were added to the stage 2 and the resultant mixture was stirred for at least one hour;
    • 4. Benzyl alcohol and Glycerin were added to stage 1
    • 5. Stage 4 was added to the mixer reactor and stirred vigorously.

An opaque yellowish gel was obtained.

US11865208B2. Pharmaceutical compositions comprising silica microspheres (2024-01-09). SOL-GEL TECHNOLOGIES LTD. [IL]. Inventors: Marina Shevachman [IL], Amira Ze' Evi [IL], Eilon Asculai [IL], Batella Benyaminovich [IL], Nir Avram [IL], Chaim Aschkenasy [IL].
Full text: Click here
Patent 2024
Benzyl Alcohol Glycerin Isopropyl Alcohol Microspheres Oleic Acid Pharmaceutical Preparations Silicon Dioxide Sorbic Acid Tretinoin triethanolamine xanthan gum
2
Tretinoin-Based Topical Gel Formulation
Not available on PMC !

Example 4

A composition comprising Tretinoin as active ingredient:

IngredientConcentration (w/w %)
Oleic acid5.00
Isopropanol10.00
BHT (Butylated Hydroxytoluene)0.02
Sorbic acid0.10
Tretinoin0.10
Silica microspheres0.70
CMC Na (carboxymethyl cellulose sodium)2.40
Natrosol (HBC)0.50
Glycerin5.00
Benzyl alcohol0.80
Poloxamer 4070.20
P. Waterq.s. 100%

The process for the preparation of the composition was as follows:

    • 1. CMC Na (carboxymethyl cellulose sodium) and Natrosol (HEC) were dispersed in water until a clear gel was formed
    • 2. Glycerin and benzyl alcohol were added to stage 1 and mixed;
    • 3. Oleic acid, isopropanol, BHT, sorbic acid, Poloxamer 407 and tretinoin were heated to 50° C. while stirring until clear solution was obtained. Then the solution was cooled to the room temperature;
    • 4. Silica Microspheres were added to the cooled oily phase and resultant mixture was stirred for at least one hour;
    • 5. Stage 4 was added to the stage 2 and stirred for one hour under vacuum.

An opaque yellowish gel was obtained.

US11865208B2. Pharmaceutical compositions comprising silica microspheres (2024-01-09). SOL-GEL TECHNOLOGIES LTD. [IL]. Inventors: Marina Shevachman [IL], Amira Ze' Evi [IL], Eilon Asculai [IL], Batella Benyaminovich [IL], Nir Avram [IL], Chaim Aschkenasy [IL].
Full text: Click here
Patent 2024
Benzyl Alcohol Ethanol Glycerin Isopropyl Alcohol Microspheres Oils Oleic Acid Pharmaceutical Preparations Poloxamer 407 Silicon Dioxide Sodium Carboxymethylcellulose Sorbic Acid Tretinoin Vacuum
3
Synthesis of Organic Microspheres
Not available on PMC !

Example 11

A reaction mixture containing Mg(OH)2-stabilised organic droplets in water was created by mixing the phases and stirring vigorously until a suitable droplet size had been achieved. The water dispersion contained 4.9 parts of Mg(OH)2 and 363 parts of water. The organic droplets contained 2.0 parts of dilauroyl peroxide, 25 parts of isooctane and 0.4 parts of trimethylolpropane trimethacrylate. α-Methylene-γ-valerolactone (MVL), methacrylamide (MAAM) and methacrylonitrile (MAN) were added in the amounts as indicated in Table 2 in parts per weight. Polymerization was performed in a sealed reactor under agitation at 62° C. during 11 hours followed by 80° C. during 4 hours. After cooling to room temperature a sample of the obtained microsphere slurry was removed for determination of the particle size distribution. After filtration, washing and drying the particles were analyzed by TMA. The dry particles contained about 23 wt. % of isooctane and had a median particle size of about 74 μm. The TMA-results are found in Table 2.

US11873378B2. Thermally expandable microspheres prepared from bio-based monomers (2024-01-16). NOURYON CHEMICALS INTERNATIONAL B.V. [NL]. Inventors: Ove Nordin [SE], Magnus Jonsson [SE].
Full text: Click here
Patent 2024
2,2,4-trimethylpentane carbene Filtration gamma-valerolactone methacrylamide methacrylonitrile Microspheres Peroxides Polymerization trimethylolpropane trimethacrylate
4
5% Benzoyl Peroxide Topical Composition
Not available on PMC !

Example 7

A composition comprising 5% Benzoyl peroxide (BPO) as active ingredient:

IngredientsConcentration (w/w %)
Benzoyl peroxide (BPO)5.00
Ethoxydiglycol9.90
Glycerin8.00
Silica microspheres2.50
Carbomer0.60
Imidazolidinyl Urea0.30
PEG-40 Hydrogenated0.20
Disodium EDTA0.10
Sodium Hydroxide0.16
Waterq.s. 100%

The process for the preparation of the compositions listed above was as follows:

    • 1. Disodium EDTA and Carbomer were added to the water and homogenized;
    • 2. Glycerin was added to stage 1 and the mixture was stirred;
    • 3. PED-40 hydrogenated castor oil was heated to 40° C. separately and after clear liquid was obtained, it was added to stage 2;
    • 4. 20% solution of sodium hydroxide was added for neutralization;
    • 5. A solution of imidazolidinyl urea in water was added to stage 4;
    • 6. Benzoyl peroxide was added to ethoxydiglycol separately and passed through Fryma colloid mill, twice;
    • 7. Silica microspheres were added to the stage 6 and resultant mixture was stirred;
    • 8. Stage 7 was added to stage 5 and the mixture was homogenized.

US11865208B2. Pharmaceutical compositions comprising silica microspheres (2024-01-09). SOL-GEL TECHNOLOGIES LTD. [IL]. Inventors: Marina Shevachman [IL], Amira Ze' Evi [IL], Eilon Asculai [IL], Batella Benyaminovich [IL], Nir Avram [IL], Chaim Aschkenasy [IL].
Full text: Click here
Patent 2024
carbomer Castor oil Colloids EDTA, Disodium Glycerin hydroxide ion imidazolidinyl urea Microspheres Peroxide, Benzoyl Pharmaceutical Preparations Silicon Dioxide Sodium-20 Sodium Hydroxide urea-EDTA
5
Synthesis of Colloidal Silica-Stabilized Microspheres
Not available on PMC !

Example 2

A dispersion comprising 242 parts of water, 30.7 parts of 50 wt. % surface-modified colloidal silica (Bindzil, 80 m2/g, particle size 32 nm surface-modified with 50% propylsilyl/50% glycerolpropylsilyl) was prepared and maintained at a pH of about 4.5. The aqueous dispersion was mixed with an organic phase that contained 2.0 parts of dilauroyl peroxide, 27 parts of isopentane and 0.3 parts of trimethylolpropane trimethacrylate. Acrylonitrile (AN) and α-methylene-γ-valerolactone (MVL) were added in the amounts as indicated in Table 1. Polymerization was performed at 62° C. in a sealed reactor under agitation during 20 hours. After cooling to room temperature a sample of the obtained microsphere slurry was removed for determination of the particle size distribution. After filtration, washing and drying the particles were analyzed by TMA. The dry particles contained about 19 wt. % of isopentane. The TMA-results and particle sizes are found in Table 1.

US11873378B2. Thermally expandable microspheres prepared from bio-based monomers (2024-01-16). NOURYON CHEMICALS INTERNATIONAL B.V. [NL]. Inventors: Ove Nordin [SE], Magnus Jonsson [SE].
Full text: Click here
Patent 2024
Acrylonitrile carbene Filtration gamma-valerolactone isopentane Microspheres Peroxides Polymerization Silicon Dioxide trimethylolpropane trimethacrylate

Top products related to «Microspheres»

1
Cd14 microbead by Miltenyi Biotec
Sourced in Germany, United States, United Kingdom, France, Sweden, Australia
CD14 MicroBeads are a magnetic labeling reagent used for the isolation of CD14-positive cells from various biological samples. They are designed for use in cell separation protocols with compatible magnetic separation systems.
2
Ls column by Miltenyi Biotec
Sourced in Germany, United States, United Kingdom
LS columns are a type of laboratory equipment used for cell separation and isolation. They are designed to facilitate the magnetic separation of cells or particles that have been labeled with magnetic beads or nanoparticles. LS columns provide a convenient and efficient method for purifying and enriching target cell populations from complex biological samples.
3
Anti pe microbeads by Miltenyi Biotec
Sourced in Germany, United States, United Kingdom, Canada, Italy, Australia
Anti-PE microbeads are magnetic beads coated with antibodies that specifically bind to the phycoerythrin (PE) fluorescent label. These microbeads are designed for the separation and enrichment of PE-labeled cells or particles using magnetic separation techniques.
4
Fetal bovine serum (fbs) by Thermo Fisher Scientific
Sourced in United States, China, United Kingdom, Germany, Australia, Japan, Canada, Italy, France, Switzerland, New Zealand, Brazil, Belgium, India, Spain, Israel, Austria, Poland, Ireland, Sweden, Macao, Netherlands, Denmark, Cameroon, Singapore, Portugal, Argentina, Holy See (Vatican City State), Morocco, Uruguay, Mexico, Thailand, Sao Tome and Principe, Hungary, Panama, Hong Kong, Norway, United Arab Emirates, Czechia, Russian Federation, Chile, Moldova, Republic of, Gabon, Palestine, State of, Saudi Arabia, Senegal
Fetal Bovine Serum (FBS) is a cell culture supplement derived from the blood of bovine fetuses. FBS provides a source of proteins, growth factors, and other components that support the growth and maintenance of various cell types in in vitro cell culture applications.
5
Anti biotin microbead by Miltenyi Biotec
Sourced in Germany, United States, Canada
Anti-biotin microbeads are a type of magnetic particle designed for the isolation and enrichment of biotin-labeled cells, proteins, or other biomolecules. These microbeads are coated with an anti-biotin antibody, which binds to the biotin label, allowing the target molecule to be separated from the rest of the sample using a magnetic field.
6
Ficoll paque plus by GE Healthcare
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Ficoll-Paque PLUS is a sterile, ready-to-use medium for the isolation of mononuclear cells from blood or bone marrow by density gradient centrifugation. It is a polysucrose and sodium diatrizoate solution with a density of 1.077 g/mL.
7
Automacs pro separator by Miltenyi Biotec
Sourced in Germany, United States, Sweden, Japan, United Kingdom, Italy, France
The AutoMACS Pro Separator is a magnetic cell separation system designed for efficient and automated cell isolation. It utilizes magnetic beads and a magnetic field to separate target cells from a heterogeneous cell population.
8
Microbead by Miltenyi Biotec
Sourced in Germany, United States, United Kingdom, Sweden
Microbeads are small, uniform beads made of polystyrene or magnetic materials. They are designed for use in various laboratory applications, including cell separation, immunoassays, and flow cytometry.
9
Cd34 microbead kit by Miltenyi Biotec
Sourced in Germany, United States, United Kingdom, Canada
The CD34 MicroBead Kit is a laboratory product that enables the separation and enrichment of CD34-positive cells from a variety of sample types, including bone marrow, peripheral blood, and leukapheresis samples. The kit utilizes magnetic beads coated with antibodies specific to the CD34 cell surface antigen to facilitate the isolation of the target cell population.
10
Cd4 microbeads by Miltenyi Biotec
Sourced in Germany, United States, France
CD4 microbeads are a lab equipment product from Miltenyi Biotec. They are magnetic beads coated with antibodies specific to the CD4 receptor, a protein found on the surface of certain immune cells.

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