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Epiretinal Membrane
Epiretinal Membrane
Epiretinal Membrane: A thin, semi-transparent layer of fibrous tissue that forms on the surface of the retina, often causing visual disturbances and distortion.
This condition, also known as macular pucker, can lead to reduced visual acuity and metamorphopsia.
Epiretinal Membranes may be idiopathic or associated with various retinal disorders, such as retinal detachment, retinal vascular disease, or inflamatory conditions.
Early detection and appropriate treatment, such as surgical removal, can help preserve vision and improve patient outcomes.
This condition, also known as macular pucker, can lead to reduced visual acuity and metamorphopsia.
Epiretinal Membranes may be idiopathic or associated with various retinal disorders, such as retinal detachment, retinal vascular disease, or inflamatory conditions.
Early detection and appropriate treatment, such as surgical removal, can help preserve vision and improve patient outcomes.
Most cited protocols related to «Epiretinal Membrane»
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Retinal Detachment
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Sub-Retinal Fluid
Angiography
Blood Vessel
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Tissue, Membrane
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Ethics Committees, Research
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cDNA Library
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Epiretinal Membrane
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We conducted a cross-sectional observational study of DM patients recruited from January 2016 through July 2017 at CUHK Eye Centre, Hong Kong Eye Hospital. Inclusion criteria for study eyes included [1 (link)] patients with type 1 or type 2 DM [2 (link)]; spherical refractive error within the range of − 8.5 to + 4.0 diopter (D) with less than 5.0 D of cylinder; and [3 (link)] VA not worse than Snellen 20/200. Exclusion criteria for study eyes included [1 (link)] prior retinal surgery, intraocular surgery, intravitreal injection, and retinal laser photocoagulation [2 (link)]; eye conditions which interfere with imaging and VA (e.g., dense cataract, corneal ulcer) [3 (link)]; glaucoma [4 (link)]; eye pathology unrelated to DM (e.g., wet age-related macular degeneration, epiretinal membrane and other maculopathy); and [5 (link)] patients who failed to cooperate when taking OCT-A images (e.g., fail to fixate their eyes for 7–8 s).
This study was conducted in accordance with the 1964 Declaration of Helsinki and was approved by the Kowloon Central/East Research Ethics Committee. Written informed consent were obtained from all subjects.
This study was conducted in accordance with the 1964 Declaration of Helsinki and was approved by the Kowloon Central/East Research Ethics Committee. Written informed consent were obtained from all subjects.
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Age-Related Macular Degeneration
Cataract
Corneal Ulcer
Epiretinal Membrane
Ethics Committees, Research
Eye
Eye Disorders
Glaucoma
Light Coagulation
Macular Degeneration
Operative Surgical Procedures
Patients
Refractive Errors
Retina
Most recents protocols related to «Epiretinal Membrane»
Participants were recruited from the movement disorder clinic of the Samsung Medical Center. The Institutional Review Board of Samsung Medical Center approved this study, and all subjects provided written informed consent. Patients were enrolled if they were diagnosed with PD based on the United Kingdom Brain Bank Criteria for PD38 (link). Patients with any of the following conditions were excluded: any neurologic disorder other than PD, systemic vasculitis, cardiovascular disease, musculoskeletal disease, end-stage renal disease, peripheral nervous system autonomic failure (diabetic neuropathy, Guillain-Barre syndrome, amyloid neuropathy, surgical sympathectomy, and pheochromocytoma, etc.), ocular pathology that could affect OCTA measurements (glaucoma, a refractive error >+6.0 diopters of spherical equivalent or <−6.0 diopters of spherical equivalent, astigmatism ≥ 3.0 diopters, epiretinal membrane, age-related macular degeneration, diabetic retinopathy, hypertensive retinopathy, retinal artery/vein occlusion, or optic neuropathy) or previous retinal surgery. Exact age- and sex-matched controls were recruited. The healthy controls were required to have normal visual acuity, normal intraocular pressure ≤21 mm Hg, and normal optic discs. The same exclusion criteria were applied to healthy controls and PD patients. Demographic and clinical data, including age, sex, and comorbid vascular risk factors (hypertension, diabetes mellitus, dyslipidemia), were collected for all enrolled participants. The UPDRS III39 (link), H&Y scale40 (link), LEDD41 (link), and MoCA42 (link) were investigated in all enrolled PD patients.
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Age-Related Macular Degeneration
Amyloid Neuropathies
Arteries
Astigmatism
Blood Vessel
Brain
Cardiovascular Diseases
Diabetes Mellitus
Diabetic Neuropathies
Diabetic Retinopathy
Dyslipidemias
Epiretinal Membrane
Ethics Committees, Research
Eye
Glaucoma
Guillain-Barre Syndrome
High Blood Pressures
Hypertensive Retinopathy
Kidney Failure, Chronic
Movement Disorders
Musculoskeletal Diseases
Nervous System Disorder
Neural-Optical Lesion
Operative Surgical Procedures
Optic Disk
Patients
Peripheral Nervous System
Pheochromocytoma
Pure Autonomic Failure
Refractive Errors
Retina
Retinal Artery Occlusion
Retinal Vein Occlusion
Sympathectomy
Tonometry, Ocular
Veins
Visual Acuity
Patients orally agreed to the use of their data in the present study. Ethical approval for this retrospective study was obtained from the Institutional Review Board of the Zhongshan Ophthalmic Centre (approval no. 2022KYPJ173). In total, 180 participants(mean age, 64.12±8.87 years; range, 52-75 years) were recruited in this study, including 109 males and 71 females. All participants underwent ICGA (SPECTRALIS Diagnostic Imaging Platform; Heidelberg Engineering, Inc.) and optical coherence tomography (OCT) (SPECTRALIS® OCT; Heidelberg Engineering Inc.) between January 2018 and January 2022 at the Zhongshan Ophthalmic Centre, Guangzhou, China.
The present study included 63 patients with PCV, 50 with AMD and 67 healthy control group. Based on the results of fundus examination, OCT, fundus fluorescein angiography (FFA) and ICGA, age- and sex-matched patients were grouped based on diagnosis into PCV, AMD and healthy control group. Only one eye was included for patients diagnosed with bilateral PCV or AMD. In healthy participants, only the eye with the best-corrected visual acuity (>20/16) was included.
The following exclusion criteria were adopted: History of prior ocular surgery or trauma(excluded 15 PCV patients); severe vitreous haemorrhage that may affect imaging examination (excluded two PCV patients); any systemic disease that may affect blood flow, such as diabetes mellitus or hypertension (excluded one PCV patients and three AMD patients); central serous chorioretinopathy (CSC); primary glaucoma; optic neuritis; retinal vein occlusion; choroidal melanoma; retinal vasculitis; uveitis; an epiretinal membrane that may affect ocular circulation (excluded one PCV patients and five AMD patients) or moderate to high myopia (defined as a spherical equivalent refractive error in phakic eyes <-3.00 D) (excluded nine healthy participants).
We conducted another screening to exclude the cases who only received monocular ICGA and OCT examination and included 44 cases of unilateral PCV and 18 cases of unilateral AMD. The diseased eye was included in the PCV/AMD group, and the healthy fellow eye was included in the PCV/AMD fellow eye group.
Following intravenous injection of 5 ml 25 mg ICG (Dandong Yichuang Pharmaceutical Co., Ltd), ICGA images were recorded. Early-stage images (5 min after dye injection) were selected for analysis. The vortex veins were separated into four categories according to a previous method (8 (link)). The branches of type I vortex veins do not converge and pass directly through the sclera, whereas all branches of type IV (complete with ampulla) converge to form the ampulla, which is a complete vortex system. Type IV systems have a larger root area due to the dilated ampulla (8 (link)). The fundus was divided into four quadrants: Superior and inferior temporal and superior and inferior nasal. Patient characteristics, such as sex, age, number, location and type of vortex veins were recorded. The sketching tool of the retinal device was used to mark the root area and diameter of the thickest branch of each vortex vein (Fig. 1 ). The centre of a concentric circle was placed on the macula, the thickest vortex vein branch intersecting with the outermost circle was selected and its diameter was measured and stored as the central vortex vein diameter (CVVD). The ends of each vortex vein branch were connected with a smooth curve and the area enclosed by the curve was defined as the root area of the vortex vein (RAVV). The width of the thickest first-order branch of the vortex vein was defined as the diameter of the peripheral thickest branch (DPTB). The mean RAVV (MRAVV) and MDPTB were calculated. Vortex vein anastomosis was observed when vortex vein branches connected the two vortex vein systems on IGCA. The percentage of eyes with vortex vein anastomosis in each group was calculated and recorded as the percentage of vortex vein anastomosis (PVVA). Subfoveal choroidal thickness (SFCT) was measured using SPECTRALIS® OCT device. All labelling was performed separately by two experienced ophthalmologists (CXC and XMX) and the mean of the two measurements was used as the final data.
The present study included 63 patients with PCV, 50 with AMD and 67 healthy control group. Based on the results of fundus examination, OCT, fundus fluorescein angiography (FFA) and ICGA, age- and sex-matched patients were grouped based on diagnosis into PCV, AMD and healthy control group. Only one eye was included for patients diagnosed with bilateral PCV or AMD. In healthy participants, only the eye with the best-corrected visual acuity (>20/16) was included.
The following exclusion criteria were adopted: History of prior ocular surgery or trauma(excluded 15 PCV patients); severe vitreous haemorrhage that may affect imaging examination (excluded two PCV patients); any systemic disease that may affect blood flow, such as diabetes mellitus or hypertension (excluded one PCV patients and three AMD patients); central serous chorioretinopathy (CSC); primary glaucoma; optic neuritis; retinal vein occlusion; choroidal melanoma; retinal vasculitis; uveitis; an epiretinal membrane that may affect ocular circulation (excluded one PCV patients and five AMD patients) or moderate to high myopia (defined as a spherical equivalent refractive error in phakic eyes <-3.00 D) (excluded nine healthy participants).
We conducted another screening to exclude the cases who only received monocular ICGA and OCT examination and included 44 cases of unilateral PCV and 18 cases of unilateral AMD. The diseased eye was included in the PCV/AMD group, and the healthy fellow eye was included in the PCV/AMD fellow eye group.
Following intravenous injection of 5 ml 25 mg ICG (Dandong Yichuang Pharmaceutical Co., Ltd), ICGA images were recorded. Early-stage images (5 min after dye injection) were selected for analysis. The vortex veins were separated into four categories according to a previous method (8 (link)). The branches of type I vortex veins do not converge and pass directly through the sclera, whereas all branches of type IV (complete with ampulla) converge to form the ampulla, which is a complete vortex system. Type IV systems have a larger root area due to the dilated ampulla (8 (link)). The fundus was divided into four quadrants: Superior and inferior temporal and superior and inferior nasal. Patient characteristics, such as sex, age, number, location and type of vortex veins were recorded. The sketching tool of the retinal device was used to mark the root area and diameter of the thickest branch of each vortex vein (
Central Serous Chorioretinopathy
Choroid
Diabetes Mellitus
Epiretinal Membrane
Ethics Committees, Research
Eye
Females
Fluorescein Angiography
Glaucoma
Healthy Volunteers
High Blood Pressures
Macula Lutea
Males
Medical Devices
Melanoma
Myopia
Nose
Ophthalmologists
Optic Neuritis
Patients
Pharmaceutical Preparations
Plant Roots
Refractive Errors
Retina
Retinal Vasculitis
Retinal Vein Occlusion
Sclera
Surgical Anastomoses
Thalamostriate Veins
Tomography, Optical Coherence
Uveitis
Veins
Vision
Visual Acuity
Vitreous Hemorrhage
Wounds and Injuries
The study included 49 AD patients and 48 healthy controls (HCs) matched by age, gender from the Department of Neurology at Xiangya Hospital of Central South University, between March 2020 and May 2022. The subjects were between 50 and 80 years of age, and the AD patients met the diagnostic criteria of “probable AD” in the 2011 edition of the National Institute on Aging and Alzheimer’s Association (NIA-AA) guidelines (McKhann et al., 2011 (link)). The exclusion criteria of the study were as follows: (1) Best-corrected visual acuity (BCVA) >6.00 D or with astigmatism >3.00 D, and (3) intraocular pressure (IOP) >21 mmHg. All participants were free of other neurologic, psychiatric disorders, and systemic diseases that may affect retina (such as diabetes mellitus and uncontrolled hypertension), as well as ocular diseases (including cataract, glaucoma, uveitis, epiretinal membrane, age-related macular degeneration, macular hole, eye trauma, and any eye surgery). The Ethics Committee of Xiangya Hospital of Central South University approved this study, and all subjects signed written informed consent.
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Age-Related Macular Degeneration
Astigmatism
Cataract
Diabetes Mellitus
Diagnosis
Epiretinal Membrane
Ethics Committees, Clinical
Eye Injuries
Gender
Glaucoma
High Blood Pressures
Macular Holes
Nervous System Disorder
Ophthalmologic Surgical Procedures
Patients
Retina
Tonometry, Ocular
Uveitis
Vision
Visual Acuity
This comparative descriptive study was approved by the Faculty of Medicine, Chulalongkorn University’s institutional review board, and the study was conducted and performed in accordance with the ethical standards set out in the Declaration of Helsinki. Informed consent was obtained from all patients. We recruited the participants with ATD who visited the Cognitive Fitness Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand into the ATD group and age- and sex-matched healthy participants who had normal cognitive status into the control group.
The diagnosis of ATD was made using the 2011 Alzheimer’s disease diagnostic guideline of the National Institutes of Health and the Alzheimer’s Association. All participants in both the ATD and the control group underwent comprehensive examinations including a complete neurological examination, the Thai Mental State Examination (TMSE), which is a Thai version of the Mini-Mental State Examination (MMSE) developed in 1993 (Supplementary File 1
Participants in both groups received a complete ophthalmic examination including best-corrected visual acuity (BCVA), intraocular pressure (IOP), blink rate (times per minute), anterior and posterior segment examination using slit lamp biomicroscopy, tear breakup time (TBUT), ocular surface evaluation using the Ocular Surface Disease Index (OSDI), and axial length measurement using optical biometry (IOLMaster 500, Carl Zeiss AG, Oberkochen, Germany). We used the criteria of the Asia Dry Eye Society (ADES) to diagnose dry eye.9 (link)
Demographic and clinical data, including medical conditions, were recorded. The exclusion criteria for both groups were: BCVA < 20/200; refractive error > ±4.00 D spherical equivalent; axial length < 22 mm and > 26 mm; IOP >22 mmHg; pre-existing macular pathologies such as age-related macular degeneration, epiretinal membrane or macular hole; other retinopathies such as retinal vascular occlusion or retinal dystrophy; pre-existing ocular diseases such as glaucoma, optic neuropathy or uveitis; previous intraocular surgery within 12 months before enrollment except for uncomplicated cataract surgery; history of ocular trauma; current smoker; and presence of other neurological or psychiatric disorders, including other types of dementia.
The diagnosis of ATD was made using the 2011 Alzheimer’s disease diagnostic guideline of the National Institutes of Health and the Alzheimer’s Association. All participants in both the ATD and the control group underwent comprehensive examinations including a complete neurological examination, the Thai Mental State Examination (TMSE), which is a Thai version of the Mini-Mental State Examination (MMSE) developed in 1993 (
Participants in both groups received a complete ophthalmic examination including best-corrected visual acuity (BCVA), intraocular pressure (IOP), blink rate (times per minute), anterior and posterior segment examination using slit lamp biomicroscopy, tear breakup time (TBUT), ocular surface evaluation using the Ocular Surface Disease Index (OSDI), and axial length measurement using optical biometry (IOLMaster 500, Carl Zeiss AG, Oberkochen, Germany). We used the criteria of the Asia Dry Eye Society (ADES) to diagnose dry eye.9 (link)
Demographic and clinical data, including medical conditions, were recorded. The exclusion criteria for both groups were: BCVA < 20/200; refractive error > ±4.00 D spherical equivalent; axial length < 22 mm and > 26 mm; IOP >22 mmHg; pre-existing macular pathologies such as age-related macular degeneration, epiretinal membrane or macular hole; other retinopathies such as retinal vascular occlusion or retinal dystrophy; pre-existing ocular diseases such as glaucoma, optic neuropathy or uveitis; previous intraocular surgery within 12 months before enrollment except for uncomplicated cataract surgery; history of ocular trauma; current smoker; and presence of other neurological or psychiatric disorders, including other types of dementia.
Age-Related Macular Degeneration
Alzheimer's Disease
Blinking
Brain
Cataract Extraction
Cognition
Dementia
Dental Occlusion
Diagnosis
Dry Eye
Epiretinal Membrane
Ethics Committees, Research
Eye Injuries
Faculty, Medical
Glaucoma
Healthy Volunteers
Laceration
Macula Lutea
Macular Holes
Mental Disorders
Mini Mental State Examination
Nervous System Disorder
Neural-Optical Lesion
Neurologic Examination
Operative Surgical Procedures
Patients
Physical Examination
Refractive Errors
Respiratory Diaphragm
Retinal Diseases
Retinal Dystrophies
Retinal Vessels
Slit Lamp Examination
Tonometry, Ocular
Uveitis
Vision
Visual Acuity
The relevant data from the articles were extracted by two reviewers (Manhong Xu and Xiaoe Fan) independently, using a standard data extraction form. The extracted data included the first author(s) or the information provider, publishing date, study design, sample size, geographical location of the research, interventions details, age, sex, outcomes, and follow-up periods. Postoperative PVR recurrence rates were extracted as the primary outcome of the meta-analysis. Secondary outcomes included retinal reattachment (complete retinal reattachment) rate, posterior retinal reattachment (post equatorial retinal reattachment/incomplete reattachment) rate, incidence of macular edema, reoperation rate after primary surgery, macular pucker or epiretinal membrane (ERM), and surgery rate of macular pucker or ERM.
Edema, Macular
Epiretinal Membrane
Operative Surgical Procedures
Recurrence
Retina
Second Look Surgery
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