Log In Sign up
The largest database of trusted experimental protocols
> Disorders > Anatomical Abnormality > Hip Dysplasia

Hip Dysplasia

Hip dysplasia is a condition where the hip joint does not form properly, leading to instability and increased risk of osteoarthritis.
It can occur in both children and adults, and early detection and treatment are critical for managing this condition.
PubCompare.ai is an innovative AI-driven platform that helps researchers optimize hip dysplasia research protocols by locating and comparing published literature, preprints, and patents.
This tool leverages AI analysis to identify the best protocols and products for your studies, enhancing reproducibility and accuracy, and ultimately improving research outcomes.

Most cited protocols related to «Hip Dysplasia»

1
Isolation and Expansion of Human MSCs
Human MSC of non-osteoporotic donors were obtained from bone marrow of femoral heads according to the described protocol [53] (link) after total hip arthroplasty due to osteoarthritis and/or hip dysplasia. MSC of patients suffering from osteoporosis were isolated from femoral heads after low-energy fracture of the femoral neck. Additional criteria for confirming primary osteoporosis in these donors were vertebrae fractures and advanced age.
Cell culture medium, fetal calf serum (FCS), trypsin-EDTA and antibiotics were obtained from PAA Laboratories GmbH, Linz, Austria. Human MSC were selected by surface adherence and expanded in DMEM/Ham's F-12 (1∶1) medium supplemented with 10% heat-inactivated FCS, 1 U/ml penicillin, 100 µg/ml streptomycin and 50 µg/ml L-ascorbic acid 2-phosphate (Sigma Aldrich GmbH, Schnelldorf, Germany).
For long term cultivation, cells were expanded at 70–90% confluence by trypsinization with 1× trypsin-EDTA and reseeding in a ratio of 1∶3. This procedure was repeated for up to x passages when the hMSC did not become confluent within 3 weeks due to replicative senescence.
Benisch P., Schilling T., Klein-Hitpass L., Frey S.P., Seefried L., Raaijmakers N., Krug M., Regensburger M., Zeck S., Schinke T., Amling M., Ebert R, & Jakob F. (2012). The Transcriptional Profile of Mesenchymal Stem Cell Populations in Primary Osteoporosis Is Distinct and Shows Overexpression of Osteogenic Inhibitors. PLoS ONE, 7(9), e45142.
Full text: Click here
Publication 2012
Antibiotics ascorbate-2-phosphate Bone Marrow Cell Aging Cell Culture Techniques Cells Degenerative Arthritides Donors Edetic Acid Femoral Neck Fractures Femur Heads Fetal Bovine Serum Hip Dysplasia Homo sapiens Osteoporosis Patients Penicillins PRSS1 protein, human Spinal Fractures Streptomycin Total Hip Arthroplasty Trypsin
2
Biomechanics of Dysplastic Acetabular Labrum

Protocol full text hidden due to copyright restrictions

Open the protocol to access the free full text link

Publication 2011
Acetabulum Anatomic Landmarks Arthrography Body Weight Bone Density Bones Cartilage Cartilages, Articular Collagen Compact Bone Dietary Fiber Females Femur Fibrosis Friction Heel Hip Dysplasia Human Body Interfacial Force Iohexol Joints Lidocaine Hydrochloride Males Muscle Rigidity Natural Springs Normal Volunteers Omnipaque Pain Patients Pelvis Permeability Pubic Bone Radiography Sacroiliac Joint simo Strains Stress Fibers Synovial Fluid Tomography, Spiral Computed Traction Vision
3
Evaluating Acetabular Dysplasia with CT Arthrography
Volunteers were recruited to match the age, weight, and body mass index (BMI) of patients with acetabular dysplasia commonly treated at our clinic. An institutional review board approved this study, and informed consent was received from 16 volunteers (7 female, 9 male) with no history of hip pain or disease.
One hip from each subject was selected randomly to receive a CT arthrogram. The hip capsule was injected with ~20 ml of a diluted contrast agent (2:1 lidocaine to OMNIPAQUE® 350, GE Healthcare Inc, Princeton, NJ) under fluoroscopic guidance. Multi-detector CT scans of the entire pelvis and both femurs were obtained within 10 mins of injection (120 kVp, 100–400 mAs, 512×512 matrix, 1.0 pitch, 300–400 mm FOV, 1.0 mm slice thickness) using a Siemens SOMATOM Definition CT Scanner. Joint traction was applied during the scan using a hare traction device to ensure that the contrast agent filled the joint space (Fig. 1a).
The CT images were read by a senior radiologist and an orthopaedic surgeon. The inclusion criteria required the hips to have a lateral center-edge angle between 25 and 40°,[21 (link),22 ] acetabular index angle (acetabular inclination or Tonnis angle) between 0 and 10°,[23 (link),24 ] qualitatively normal joint congruity, bone sphericity and cartilage morphology, and no signs of OA. CT images needed to show distribution of contrast sufficient to distinguish acetabular and femoral cartilage (Fig. 1a). Based on these criteria, 6 subjects were excluded. For the remaining 10 (5 female, 5 male), the lateral center-edge angle was 33.5±5.4° and acetabular index was 4.6±3.7°. Age, weight and BMI were 26±4 yrs, 70.0±13.9 kg and 23±3.8, respectively.
Harris M.D., Anderson A.E., Henak C.R., Ellis B.J., Peters C.L, & Weiss J.A. (2011). Finite Element Prediction of Cartilage Contact Stresses in Normal Human Hips. Journal of Orthopaedic Research, 30(7), 1133-1139.
Publication 2011
Acetabulum Arthrography Bones Capsule Cartilage CAT SCANNERS X RAY Coxa Ethics Committees, Research Femur Fluoroscopy Hares Hip Dysplasia Index, Body Mass Joints Lidocaine Males Medical Devices Omnipaque Orthopedic Surgeons Pain Patients Pelvis Radiologist Radionuclide Imaging Traction Voluntary Workers Woman
4
Hip Displacement Measurement Reliability
Subjects were assisted to take a supine position so their their pelvises could be parallel to each other and both their coxae could be in a neutral position while undergoing plain hip radiographies.11 (link),12 (link) This study was retrospectively conducted, and hip displacement was measured by two raters (A and B) using plain hip radiographs. The two raters were well-acquainted with pelvic and coxal structures and radiologic indexes, and measured hip displacement in accordance with standardized methods.4 (link)
The outermost edge of the acetabular roof was regarded as the datum point from where the Perkin's line (P-line) was drawn. Likewise, another P-line was drawn from the lateral edge of the sourcil. The former and the latter method were defined as the classic and modified method, respectively (Fig. 2).
To evaluate intra-rater reliability, the displacement of 200 hip joints was measured 3 times at intervals of 1 week without data on previous measurements, and an analysis was made of the reliability amongst measured values. In order to evaluate inter-rater reliability, the displacement of 200 hip joints was measured in the same way, and an analysis was made of the reliability amongst mean values.
The reliabilities were evaluated in patients with or without hip dysplasia. In accordance with the descriptions of Ogata et al.13 (link) and Agus et al.,8 (link) the acetabular roof was classified as to the shape of the sourcil. Type I and II cases where the lateral edge of the acetabular roof and that of the sourcil are superimposed, were regarded as normal. On the other hand, type III and IV were classified as hip dysplasia.
Kim S.M., Sim E.G., Lim S.G, & Park E.S. (2012). Reliability of Hip Migration Index in Children with Cerebral Palsy: The Classic and Modified Methods. Annals of Rehabilitation Medicine, 36(1), 33-38.
Publication 2012
Acetabulum Coxa Hip Dislocation Hip Dysplasia Hip Joint Joints Patients Pelvis X-Rays, Diagnostic
5
Genetic Loci and Osteoarthritis Endophenotypes
The 9 replicating genetic loci were examined for association in radiographic osteoarthritis endophenotypes. This was done for 3 phenotypes: minimal Joint space width (mJSW), and two measures of hip shape deformities known as strong predictors for osteoarthritis: acetabular dysplasia (measured with Center Edge-angle), and cam deformity (as measured with alpha angle). For mJSW association statistics for the variants were looked-up in a previously published GWAS, which joint analyzed data from the Rotterdam Study I (RS-I), Rotterdam Study II (RS-II), TwinsUK, SOF and MrOS using standardized age, gender and population stratification (four principal components) adjusted residuals from linear regression17 . For the two hip shape phenotypes, CE-angle and alpha angle were measured as previously published. CE-angle was analyzed as a continuous phenotype. We conducted GWAS on a total of 6880 individuals from the Rotterdam Study I (RS-I), Rotterdam Study II (RS-II), Rotterdam Study III (RS-III) and CHECK43 (link) datasets using standardized age, gender adjusted residuals from linear regression. For cam-deformity individuals with an alpha-angle >60° were defined as a case (n=639), while all others were controls (4339). The GWAS was done on individuals from RS-I, RS-II and CHECK, using age, sex and principal components to adjust for population stratification as covariates. The results of the separate cohorts were combined in a meta-analysis using inverse variance weighting with METAL40 (link). Genomic control correction was applied to the standard errors and P-values before meta-analysis.
Zengini E., Hatzikotoulas K., Tachmazidou I., Steinberg J., Hartwig F.P., Southam L., Hackinger S., Boer C.G., Styrkarsdottir U., Gilly A., Suveges D., Killian B., Ingvarsson T., Jonsson H., Babis G.C., McCaskie A., Uitterlinden A.G., van Meurs J.B., Thorsteinsdottir U., Stefansson K., Smith G.D., Wilkinson J.M, & Zeggini E. (2018). Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis. Nature genetics, 50(4), 549-558.
Publication 2018
7-bis(beta-chloroethyl)aminomethyl-6,14-endoethenotetrahydrooripavine Congenital Abnormality Degenerative Arthritides Genetic Loci Genome Genome-Wide Association Study Hip Dysplasia Joints Melkersson-Rosenthal Syndrome Phenotype Radiography

Most recents protocols related to «Hip Dysplasia»

1
Hip Joint CT Imaging Analysis
This retrospective computed tomography (CT) scan image analysis study was approved by the institutional review board. Adults aged 20–50 years with normal hip joints who underwent full-length lower extremity CT (CT lower extremity, CT lower extremity angiography, and CT deep vein thrombosis) at our institution between June 2020 and May 2021 were screened. The exclusion criteria were as follows: (1) patients with osteoarthritis or osteophytes of the hip joint; (2) patients with previous hip surgery, hip dysplasia, congenital anomalies, or traumatic deformities; and (3) patients whose pelvis and femurs were not included in the image. Total 143 subjects were screened, and ultimately, 71 subjects (38 men and 33 women) and 142 hips were enrolled in the study.
Cho B.W., Kwon H.M., Park J.Y., Park K.K., Kim T, & Lee W.S. (2023). Sex differences in the anatomy of the anterior–superior acetabular rim in relation to pincer-type femoroacetabular impingement in Koreans: a three-dimensional quantitative analysis. Journal of Orthopaedic Surgery and Research, 18, 161.
Full text: Click here
Publication 2023
Adult Computed Tomography Angiography Congenital Abnormality Coxa Deep Vein Thrombosis Degenerative Arthritides Ethics Committees, Research Femur Hip Dysplasia Hip Joint Lower Extremity Operative Surgical Procedures Osteophyte Patients Pelvis Radionuclide Imaging Woman X-Ray Computed Tomography
2
Comprehensive Congenital Hip Dislocation Treatment
Initial CR was performed on all 65 hips in accordance with the hospital protocol, skin traction was not performed in any case. CR was performed under general anesthesia, tenotomy of the adductor group was performed in all cases. The reduction was confirmed by observing the femoral head in the acetabulum inside the inferior and internal quadrant of Putti, (the evaluation was done retrospectively by observing the radiological images by 2 pediatric orthopedists to obtain a Cohen Kappa κ= 0.85). In addition, they were considered the following criteria: A. Good reduction if: Shenton line intact with legs in neutral position; < 2 mm discrepancy compared with the contralateral hip of the distance from the inner acetabular cortex to the medial corner of the femoral methaphysis in unilateral cases; Femoral methaphysis directed toward triradiate cartilage on abduction radiographs; and reduction stable we the safe zone of Ramsey. B. Adequate reduction (mild lateralization) if: Shenton line intact or slightly broken with legs in neutral position; a discrepancy of 2 to 5 mm in the distance from the inner acetabular cortex to the medial corner of the femoral methaphysis in unilateral cases; femoral methaphysis directed toward triradiate cartilage on abduction radiographs; and reduction stable we the safe zone of Ramsey.[20 (link)] Subsequently, a hip spica plaster cast was placed in a human position at 90° flexion, 45° abduction and slight internal rotation, with gently elevation of the greater trochanter like an Ortolani movement, applying slight force.[21 ] At 6 weeks an AP radiograph of the pelvis was taken to asses hip reduction (the assessment was retrospective by 2 pediatric orthopedists and obtained a Cohen Kappa [κ= 0.83], if it was considered reduced, sedation was scheduled, a new hip spica plaster cast was then placed in lange “second” position knees extended, 45° abduction, and maximum internal rotation),[22 (link)] but if a redislocation was observed the surgeon decided according to his judgment and experience to operate OR, and add FO, PO or all. In the outpatient clinic, 6 weeks later, the previous plaster cast was cut slightly above the knee, and its use was continued for another 6 weeks, until its removal (it works like a full-time abduction bar), if the parents had resources to order a rigid custom-made abduction brace, it was used for 1 year, with the hip flexed and abducted at 90° and 45° respectively. In the subsequent consultations, the surgeon evaluated residual dysplasia like the acetabular angle FAI, femoral anteversion, AVN or any sequelae and decided on FO, and PO at his judgment and experience.
Charles-Lozoya S., Chávez-Valenzuela S., Cobos-Aguilar H., Manilla-Muñoz E., De La Parra-Márquez M.L., Arriaga-Cazares H.E, & García-Hernández A. (2023). Closed reduction evaluation in dysplastic hip with the Ömeroğlu system in children aged 24 to 36 months. Medicine, 102(9), e32649.
Publication 2023
Acetabulum Braces Cartilage Cortex, Cerebral Equus asinus Femur Femur Heads General Anesthesia Hip Dysplasia Homo sapiens Knee Leg Movement Muscle Rigidity Orthopedic Surgeons Parent Pelvis Plaster Casts Sedatives sequels Skin Surgeons Tenotomy Traction Trochanters, Greater X-Rays, Diagnostic
3
Radiographic Classification of Developmental Dysplasia of the Hip
International Hip Dysplasia Institute (IHDI) is a radiographic classification system for initial evaluation of DDH, which takes as reference the hilgenreiner (H), Perkin lines (start from the triradiate cartilage and the outermost edge of the acetabulum, respectively), diagonal, and H point. Ramo[13 (link)] estimates an intraclass correlation interval (ICC) of 0.90 to 0.95 (Fig. 1a). Ogata “refined” CE Angle,[14 (link)] that evaluates bone condensation of the acetabular roof with a line that was drawn from the center of the metaphysis of the femoral neck, parallel to the longitudinal body axis and another line to the most lateral portion of said bone condensation (Fig. 1e), Ömeroğlu refers a reproducibility (κ= 0.54–0.76).[15 (link)] Buchholz–Ogden classification[16 ] to graduate AVN of the proximal femoral epiphysis AVN and includes type I: irregular ossification of the femoral head, II: lateral epiphyseal closure, valgus deformity of the head on the femoral neck, III: necrosis in the physis with growth alteration in the entire physis, IV: early closure of the medial physis with varus deformity, Roposch[17 (link)] refers a κ= 0.34 to 0.61. Acetabular index was estimated with initial acetabular index (IAI) and final acetabular index (FAI), by taking the H line as reference and a diagonal line up to the outer edge of the acetabular roof. They were measured twice, and the average was taken as the final measurement.
To quantify the main radiological results, the radiographic classification outcome system used “Ömeroğlu,”[18 (link)] which includes 3 measurements, the center edge angle of Wiberg, the acetabular angle of sharp, the center-trochanter distance (CTD), as well as 3 modifiers: the Ogata angle grade IV, the need for secondary treatment and the redislocation (Fig. 1 a–f). The score ranges fluctuated between 1 and 6 points and were considered satisfactory in hips with ≥ 5 points. Ömeroğlu[19 (link)] reported an inter and intraobserver reliability of 0.81 and 0.88, respectively.
Charles-Lozoya S., Chávez-Valenzuela S., Cobos-Aguilar H., Manilla-Muñoz E., De La Parra-Márquez M.L., Arriaga-Cazares H.E, & García-Hernández A. (2023). Closed reduction evaluation in dysplastic hip with the Ömeroğlu system in children aged 24 to 36 months. Medicine, 102(9), e32649.
Publication 2023
Acetabulum Bones Cartilage Congenital Abnormality Coxa Epiphyseal Cartilage Epiphyses Epistropheus Femur Femur Heads Head Hip Dysplasia Human Body Neck, Femur Necrosis Osteogenesis Radiography Trochanter
4
Radiographic Evaluation of Normal and Near-Normal Canine Hip Joints
The retrospective study protocol was approved by the Scientific Committee of the Department of Surgery and Radiology at the Faculty of Veterinary Medicine, Cairo University prior to investigation. Medical records and extended VD pelvic radiographs of adult Labrador Retrievers and German Shepherds with normal and near-normal CFJs were retrieved from the database of the Small Animal Hospital, University of Florida, College of Veterinary Medicine. All enrolled pelvic radiographs were belonging to individuals with no clinical or radiographic signs of orthopaedic diseases. All digitized radiographs were approved in terms of quality and positioning (with parallel femurs and no pelvic tilting) [19 (link), 20 (link)] and were sorted out into normal (grade A) and near normal (grade B) categories by board-certified and qualified radiologists (CB and AM). This categorization was carried out according to the morphometric criteria previously established by the Federation Cynologique Internationale (FCI) scoring protocol of CHD [10 (link), 21 , 22 (link)]. Accordingly, the hip joint was considered normal (grade A) in both Labrador Retrievers and German Shepherds if the CFJ space appeared narrow with sharply margined perfectly parallel articular margins, circumferentially (perfectly congruent joint), and a NA ≥ 105o. The near-normal CFJ (grade B) showed sharply margined and nonparallel coxofemoral articular surfaces with associated slightly widened joint space (minimal joint incongruence). The enrolled CFJs were considered near-normal if the NAs were ≥ 105o in Labrador Retrievers and ≤ 105° in German Shepherds. Coxofemoral joints with radiographic evidence of hip dysplasia (grades C to E) were excluded from the current report.
Nahla M.A., Berry C.R, & Mostafa A.A. (2023). Radiographic quantification of the normal and near-normal coxofemoral conformation in Labrador Retrievers and German Shepherds: a comparative study. Irish Veterinary Journal, 76, 6.
Full text: Click here
Publication 2023
Adult Faculty Femur Hip Dysplasia Hip Joint Joints Operative Surgical Procedures Pelvis Radiologist X-Rays, Diagnostic
5
Clinical Risk Factors Protocol
In line with the previously developed models, we extracted the following variables: age, gender, BMI, smoking status (yes/no), the presence of predefined comorbidities (yes/no), and predefined medication use (yes/no) [2 (link)]. Comorbidities included the presence of an immunological disorder, rheumatoid arthritis, diabetes mellitus, liver disease, heart disease, disease of the central nervous system, and/or hip dysplasia. Information collected regarding medication use included the of use of vitamin K antagonists, and/or non-steroid anti-inflammatory drugs (NSAID) [2 (link)].
Sweerts L., Dekkers P.W., van der Wees P.J., van Susante J.L., de Jong L.D., Hoogeboom T.J, & van de Groes S.A. (2023). External Validation of Prediction Models for Surgical Complications in People Considering Total Hip or Knee Arthroplasty Was Successful for Delirium but Not for Surgical Site Infection, Postoperative Bleeding, and Nerve Damage: A Retrospective Cohort Study. Journal of Personalized Medicine, 13(2), 277.
Full text: Click here
Publication 2023
antagonists Anti-Inflammatory Agents, Non-Steroidal Diabetes Mellitus Gender Heart Diseases Hepatobiliary Disorder Hip Dysplasia Immune System Diseases Nervous System Disorder Pharmaceutical Preparations Rheumatoid Arthritis Vitamin K

Top products related to «Hip Dysplasia»

1
Somatom definition by Siemens
Sourced in Germany, United States, Japan, Netherlands
The Somatom Definition is a computed tomography (CT) scanner developed by Siemens. It is a diagnostic imaging device that uses X-rays to create detailed cross-sectional images of the body.
2
Centricity pacs by GE Healthcare
Sourced in United States, United Kingdom
Centricity PACS is a medical imaging and information management system developed by GE Healthcare. It is designed to store, manage, and distribute digital medical images and associated clinical data across healthcare organizations. The system provides secure access to patient imaging studies and reports, enabling healthcare professionals to view and interpret medical images from various modalities.
3
Spss software by IBM
Sourced in United States, Japan, United Kingdom, Germany, Austria, Belgium, China, Italy, India, Israel, France, Spain, Denmark, Canada, Hong Kong, Poland, Australia
SPSS is a software package used for statistical analysis. It provides a graphical user interface for data manipulation, statistical analysis, and visualization. SPSS offers a wide range of statistical techniques, including regression analysis, factor analysis, and time series analysis.
4
Syngo via frontier by Siemens
Sourced in Germany
Syngo.via Frontier is a software platform developed by Siemens that provides advanced visualization and analysis tools for medical imaging data. The core function of Syngo.via Frontier is to process and display medical images from various modalities, such as CT, MRI, and PET, to aid in diagnostic and treatment planning.
5
Ficoll paque by GE Healthcare
Sourced in Sweden, United States, United Kingdom, Germany, Canada, Belgium, Italy, Australia, Austria, France, Japan, Singapore, Denmark
Ficoll-Paque is a density gradient medium used for the isolation and purification of cells, such as mononuclear cells, from whole blood or other biological samples. It is designed to separate different cell types based on their density differences during centrifugation.
6
Tri lock bps by DePuy
Sourced in United States
The Tri-lock BPS is a laboratory equipment product designed for the secure attachment of various components. It features a three-point locking system to provide a stable and reliable connection. The core function of the Tri-lock BPS is to enable the secure and precise positioning of laboratory equipment and fixtures.
7
Traumacad by Brainlab
Sourced in Germany, United States
TraumaCad is a diagnostic and pre-operative planning software designed for orthopedic procedures. It provides tools for measuring and planning various aspects of orthopedic surgeries, such as joint replacements, fracture fixation, and deformity corrections.
8
Aquilion 64 by Toshiba
Sourced in Japan, Germany, United States
The Aquilion 64 is a computed tomography (CT) scanner manufactured by Toshiba. It is designed to capture high-quality, three-dimensional images of the human body. The Aquilion 64 is capable of producing 64 slices of image data per rotation, allowing for rapid and efficient data acquisition.
9
Sas statistical software version by SAS Institute
Sourced in United States
SAS statistical software, version is a comprehensive data analysis and statistical modeling software package. It provides a wide range of tools for data management, analysis, and visualization. The software offers a flexible and powerful programming environment for conducting statistical analyses, predictive modeling, and business intelligence. SAS statistical software, version is utilized across various industries and research fields to support data-driven decision-making.
10
Synapse pacs system by Fujifilm
Sourced in United States
The Synapse PACS system is a comprehensive digital imaging and communications in medicine (DICOM) solution. It provides a centralized platform for managing, storing, and accessing medical images and associated data. The Synapse PACS system is designed to streamline healthcare workflows and enhance patient care.

More about "Hip Dysplasia"

Hip dysplasia is a musculoskeletal condition where the hip joint fails to develop properly, leading to joint instability and an increased risk of osteoarthritis.
This condition can affect both children and adults, and early detection and appropriate treatment are crucial for managing the condition effectively.
PubCompare.ai is an innovative AI-driven platform that helps researchers optimize their hip dysplasia research protocols.
By leveraging artificial intelligence, this tool analyzes and compares published literature, preprints, and patents to identify the best protocols and products for your studies.
This enhances the reproducibility and accuracy of your research, ultimately improving your research outcomes.
The Somatom Definition, Centricity PACS, and Syngo.via Frontier are medical imaging technologies that can be used to diagnose and monitor hip dysplasia.
Similarly, the Ficoll-Paque and Tri-lock BPS are products that may be utilized in the research and treatment of this condition.
The TraumaCad and Aquilion 64 are additional tools that can assist in the assessment and management of hip dysplasia.
The SAS statistical software and Synapse PACS system are also relevant in the context of hip dysplasia research and patient care.
These tools can be used for data analysis, image management, and clinical decision-making.
By incorporating these related terms, abbreviations, and sub-topics, researchers and healthcare professionals can enhance their understanding of hip dysplasia and leverage the latest technologies and innovations to improve patient outcomes.
Remember, early detection and appropriate treatment are key to managing this condition effectively.