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Vascular Malformations

Vascular Malformations are abnormal formations of blood vessels that can occur in any part of the body.
These lesions are often present at birth and can grow or change over time.
They can range from small, simple vascular birthmarks to large, complex tangles of veins, arteries, and lymphatic vessels.
Vascular Malformations can cause a variety of symptoms, including pain, swelling, bleeding, and cosmetic concerns.
Proper diagnosis and management are important to prevent complications and improve quality of life.
Reserach into the underlying causes, optimal treatment approaches, and long-term outcomes for Vascualr Malfromations is an area of active study.

Most cited protocols related to «Vascular Malformations»

Age-related Brain Structure Changes

MRI data were acquired in a group of 66 healthy subjects (31 males, 35 females, median age = 36.7 years, range = 23.0-81.6 years, all right-handed). We tested for linear and nonlinear relationships between brain structure and age (see below) and also performed subgroup analyses for which we divided subjects into young adults (YA) (n = 37, 16 males, 21 females, median age = 29.1, range = 23.0-40.2 years), middle-aged adults (MA) (n = 19, 9 males, 10 females, median age = 48.0, range = 41.0-59.6 years) and older adults (OA) (n = 10, 6 males, 4 females, median age = 67.9, range = 60.0-81.6 years). The ages chosen for defining the different age subgroups are broadly consistent with previous studies in YA (Giorgio et al., 2008; McLaughlin et al., 2007; O'Sullivan et al., 2001; Pfefferbaum et al., 2005; Sullivan et al., 2006 ), MA (Salat et al., 2005a,b ) and OA (McLaughlin et al., 2007; Salat et al., 2005b ).
None of the participants had a history of psychiatric or neurological disease or substance abuse. On MRI they did not show overt abnormalities such as infarct, vascular malformation or tumour and none of them had WM lesions. Informed written consent was obtained from all participants according to ethical approval from the Oxfordshire Research Ethics Committee C.

Giorgio A., Santelli L., Tomassini V., Bosnell R., Smith S., De Stefano N, & Johansen-Berg H. (2010). Age-related changes in grey and white matter structure throughout adulthood. Neuroimage, 51(3-2), 943-951.

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Publication 2010

Adult Aged Brain Congenital Abnormality Ethics Committees, Research Females Healthy Volunteers Infarction Males Neoplasms Nervous System Disorder Substance Abuse Vascular Malformations Young Adult

Spontaneous Intracerebral Hemorrhage Eligibility

The primary phenotype is a spontaneous ICH. All cases must meet the following eligibility criteria:

Age 18 years or greater

Resident for at least 6 months within 75 miles of the recruiting center (100 miles for population centers with less than 1 million)

Be of non-Hispanic white, non-Hispanic black, or Hispanic race-ethnicity by self-report.

Diagnosis of spontaneous ICH (see definition)

Ability of the patient or legal representative to provide informed consent.

Intracerebral hemorrhage is defined as (adapted from the Classification of Cerebrovascular Disease III-1989) a spontaneous, non-traumatic, abrupt onset of severe headache, altered level of consciousness, and/or focal neurologic deficit that is associated with a focal collection of blood within the brain parenchyma seen on neuroimaging or at autopsy and is not due to hemorrhagic conversion of a cerebral infarction.^{7 (link),8 (link)} This includes warfarin-associated ICH as well as peripartum ICH. Exclusions include malignancies that lead to coagulopathy, dural venous sinus thrombosis-associated hemorrhage, hemorrhages due to vascular malformations, aneurysms, tumors or hemorrhagic conversion of recent ischemic stroke. To determine a patient’s eligibility as a study case, study neurologists review the patient’s clinical presentation and neuroimaging.

Woo D., Rosand J., Kidwell C., McCauley J.L., Osborne J., Brown M.W., West S.E., Rademacher E.W., Waddy S., Roberts J.N., Koch S., Gonzales N.R., Sung G., Kittner S.J., Birnbaum L., Frankel M., Daniel Testai F., Hall C.E., Elkind M.S., Flaherty M., Coull B., Chong J.Y., Warwick T., Malkoff M., James M.L., Ali L.K., Worrall B.B., Jones F., Watson T., Leonard A., Martinez R., Sacco R.I, & Langefeld C.D. (2013). The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) Study Protocol. Stroke; a journal of cerebral circulation, 44(10), 10.1161/STROKEAHA.113.002332.

Publication 2013

Aneurysm Autopsy BLOOD Blood Coagulation Disorders Brain Cerebral Hemorrhage Cerebrovascular Disorders Diagnosis Eligibility Determination Ethnicity Headache Hemorrhage Hemorrhagic Stroke Hispanics Infarction Malignant Neoplasms Neoplasms Neurologists Patients Phenotype Sinus Thrombosis, Intracranial Vascular Malformations Vision Warfarin

Quantification of CYP3A4 and GFAP in Epileptic Brain

Histologic and immunohistochemical (IHC) staining were performed from blocks of neocortical epileptic tissues obtained during surgery (Table S1). Human drug-resistant epileptic brain (n = 3) were evaluated for the study. For histologic studies, five sections (30–35 μm) from the temporal cortex were collected and stained with 1% Cresyl violet (CV) for cytoarchitectural analysis (dyslamination, abnormal neuronal morphology, ectopias, and vascular malformations. Free floating sections were stained with Cyp3A4, GFAP, and vWF (Marchi et al., 2004 (link), 2006 (link)). We used: rabbit polyclonal anti-human Cyp3A4 (AB1254) (1:1,000, Chemi-Con, now Millipore, U.S.A.); mouse monoclonal anti-GFAP (G 3893, 1:100; Sigma, St Louis, MO, U.S.A.); mouse monoclonal anti-vWF (3H3126, 1:200; Santa Cruz, U.S.A.). Secondary antibodies: Texas red affinipure donkey anti-mouse IgG (1:100; Jackson Laboratories Inc., West Grove, PA, U.S.A.), and fluorescein isothiocyanate (FITC)–conjugated affinipure donkey anti-rabbit IgG (1:100; Jackson Laboratories Inc., West Grove, PA, U.S.A.). Autofluorescence was blocked with Sudan black B. Sections were analyzed by fluorescent microscopy.
CYP3A4 expression was quantified by measuring the green fluorescent signal in nine sections (n = 3 patients, Table S1). For quantification of CYP3A4 and GFAP expression, green and red fluorochromes were excited by a laser beam at 488 and 575 nm, respectively. All sections were scanned in the 1,600 × 1,200 pixel format in the x–y direction and the acquired images were processed using QCapture-Pro Software and Photoshop CS2. These measurements represent the “volume” of fluorescence (Marchi et al., 2006 (link)). Pixel number and intensity were measured using a green (or red) channel only and adjustment of the background signal to zero.

Ghosh C., Gonzalez-Martinez J., Hossain M., Cucullo L., Fazio V., Janigro D, & Marchi N. (2010). Pattern of P450 expression at the human blood–brain barrier: Roles of epileptic condition and laminar flow. Epilepsia, 51(8), 1408-1417.

Publication 2010

anti-IgG Antibodies Brain cresyl violet Cytochrome P-450 CYP3A4 Ectopic Tissue Epilepsy Equus asinus Fluorescein Fluorescence Fluorescent Dyes Glial Fibrillary Acidic Protein Homo sapiens isothiocyanate Microscopy Mus Neurons Operative Surgical Procedures Patients Pharmaceutical Preparations Rabbits Sudan Black B Temporal Lobe Tissues Vascular Malformations

Histological Analysis of Epilepsy Specimens

Histologic and immunohistochemical staining were performed on sections (25–30 μm) obtained from blocks of resected tissues (Table 1). Specimens from temporal lobe epilepsy (TLE)—one tuberous sclerosis (TS) and one cavernous angioma (CA)—were included in the study. Five sections/sample from were stained with 1% Cresyl violet (CV) for cytoarchitectural analysis (dyslamination, ectopic neurons, and vascular malformations).

Ghosh C., Marchi N., Desai N.K., Puvenna V., Hossain M., Gonzalez-Martinez J., Alexopoulos A.V, & Janigro D. (2011). Cellular localization and functional significance of CYP3A4 in the human epileptic brain. Epilepsia, 52(3), 562-571.

Publication 2011

Angioma, Cavernous cresyl violet Epilepsy, Temporal Lobe Neurons Tissues Tuberous Sclerosis Vascular Malformations

Longitudinal Cohort Study of Intracerebral Hemorrhage

Participants were enrolled in an ongoing single-center longitudinal cohort study of ICH as previously described.^{3 (link)} Participants were recruited among consecutive patients aged 18 years or older, admitted to Massachusetts General Hospital from July 1994 to December 2011 with acute ICH (onset of symptoms <24 hours prior to presentation) confirmed by computed tomography scan. Patients with hemorrhage resulting from trauma, conversion of an ischemic infarct, rupture of a vascular malformation or aneurysm, or brain tumor were excluded.
In light of known ethnic and racial variations in hypertension incidence and severity, participants were asked at enrollment to self-identify race and ethnicity, choosing from the options recommended by the Office for Management and Budget and the National Institutes of Health for use in research studies.⁸ ICH location was assigned at the time of the incident ICH by study investigators blinded to clinical information. Lobar ICH was defined as selective involvement of cerebral cortex, underlying white matter, or both; nonlobar ICH was defined as selective involvement of thalami, basal ganglia, or brainstem. In accordance with previously published methods, individuals with cerebellar ICH were excluded from analysis given that both arteriolosclerosis and CAA are found at this location.^{3 (link),9 (link)} Pre-ICH baseline data were prospectively collected by trained study staff via in-person interview at time of enrollment and included demographic information, medical history, and pre-ICH drug exposure.
The study protocol was approved by the Massachusetts General Hospital institutional review board. Written informed consent was obtained from all study participants or their surrogates.

Biffi A., Anderson C.D., Battey T.W., Ayres A.M., Greenberg S.M., Viswanathan A, & Rosand J. (2015). Association Between Blood Pressure Control and Risk of Recurrent Intracerebral Hemorrhage. JAMA, 314(9), 904-912.

Publication 2015

Aneurysm Arteriolosclerosis Basal Ganglia Brain Neoplasms Brain Stem Cerebellum Cortex, Cerebral Ethics Committees, Research Ethnicity Hemorrhage High Blood Pressures Infarction Patients Pharmaceutical Preparations Radionuclide Imaging Thalamus Vascular Malformations White Matter Wounds and Injuries X-Ray Computed Tomography

Most recents protocols related to «Vascular Malformations»

Cardiac Dysfunction in Pediatric VSD with PAH

Our study cohort included eight children aged 6–10 years who were hospitalised in the Affiliated Hospital of Southwest Medical University, China on June 2022. Four of the children were diagnosed by echocardiography as VSD without PAH (control group, n = 4) and the other four were diagnosed by echocardiography and right cardiac catheterisation as moderate or severe PAH secondary to VSD (PAH group, n = 4). A diagnosis of PAH by right-heart catheterisation was defined as a mean pulmonary arterial pressure >25 mmHg at rest, a pulmonary capillary wedge pressure <15 mmHg and a pulmonary vascular resistance of >3 Wood units. We excluded patients receiving targeted therapy for PAH and those diagnosed with other intracardiac malformations, such as patent ductus arteriosus, large atrial septal defect, or other related conditions, like congenital lung disease, bronchial asthma and congenital pulmonary vascular malformation.
During the cardiac operation, atrial appendage specimens were collected from all patients before cardiopulmonary bypass and blood samples were collected via the jugular vein before performing the midline sternotomy. The plasma and right atrial appendage specimens were then aliquoted and stored at −80°C until RNA extraction.

Yang Q., Fan W., Lai B., Liao B, & Deng M. (2023). lncRNA-TCONS_00008552 expression in patients with pulmonary arterial hypertension due to congenital heart disease. PLOS ONE, 18(3), e0281061.

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Publication 2023

Asthma Atrial Septal Defects Atrium, Right Auricular Appendage BLOOD Blood Vessel Cardiopulmonary Bypass Catheterizations, Cardiac Child Congenital Abnormality Congenital Disorders Echocardiography Jugular Vein Lung Lung Diseases Median Sternotomy Patent Ductus Arteriosus Patients Plasma Pulmonary Wedge Pressure Surgical Procedure, Cardiac Therapeutics Vascular Malformations

Retrospective Study of Acute Ischemic Stroke

Study materials were collected from the Suzhou Taicang Hospital of Traditional Chinese Medicine from November 2020 to August 2022. There were 178 cases where a diagnosis of AIS was made. The ethics committee of the Suzhou Taicang Hospital of Traditional Chinese Medicine approved this study and waived patient consent due to the retrospective study design (Grant No. 2022-023). All study procedures were carried out in accordance with the relevant guidelines and regulations.
Among these 178 cases, 57 patients who met the following criteria at our institution were retrospectively included in this study: (1) all patients clinically diagnosed with AIS had undergone one-stop, plain CT scan, CTP, and CTA, (2) all scans were performed within the 24 h of the onset of AIS, (3) all data had undergone valid quantitative analysis by F-STROKE (16 (link)), an automated perfusion analysis software (version 1.0.18; Neuroblast, Ltd. Co.), (4) all diagnostic images were clear, with no obvious motion artifacts or metallic artifacts evident, (5) no other brain diseases, such as brain tumors, vascular malformations, or cerebral hemorrhages, and (6) no previous history of thrombolytic therapy or massive cerebral infarction. Exclusion criteria included (1) the time of onset was >24 h, (2) the quantitative value was too small (ischaemic focus range: <5 mL), as determined using the F-STROKE software, (3) a history of thrombolytic therapy or massive cerebral infarction, (4) brain tumor or cerebrovascular disease, or (5) CT image quality did not meet the evaluation requirements (e.g., based on the presence of titanium clip artifacts or heavy motion artifacts). A flow chart of the inclusion/exclusion process is displayed in Figure 1. The CTA showed corresponding stenosis or occlusion in 50 cases and was normal in 7 cases.

Huang J., Chen J., Wang X., Hao L., Zhang J., Zhang X., Sheng Z, & Liu K. (2023). The diagnostic value of quantitative parameters on dual-layer detector-based spectral CT in identifying ischaemic stroke. Frontiers in Neurology, 14, 1056941.

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Publication 2023

Brain Diseases Brain Neoplasms Cerebral Hemorrhage Cerebral Infarction Cerebrovascular Accident Cerebrovascular Disorders Clip Dental Occlusion Diagnosis Ethics Committees, Clinical Metals Patients Perfusion Radionuclide Imaging Stenosis Thrombolytic Therapy Titanium Vascular Malformations X-Ray Computed Tomography

Emergent Surgical Clipping for aSAH

This was a retrospective and single-center cohort study. Patients who underwent emergent surgical clipping after an aSAH under general anesthesia at Beijing Tiantan Hospital, Capital Medical University, between 2015 and 2020 were included in this study. All the neurosurgical data were retrieved from the “Long-term Prognosis of Emergency Aneurysmal Subarachnoid Hemorrhage (LongTEAM)” study. This study was approved by the local institutional ethical review board. The study was registered in ClinicalTrials.gov with the number NCT04785976. Written informed consent for clinical analyses was obtained from the patients or their surrogates. The article adhered to the applicable Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) standards for observational studies.
Adult patients with emergent admission for surgical clipping due to aSAH were enrolled in this study. The initial clinical severity of aSAH was accessed immediately upon admission. SAH was documented by angiography and confirmed by computed tomography or lumbar puncture. The exclusion criteria were as follows: (1) treatment by both surgical clipping and endovascular coiling; (2) other neurological diseases (tumor, vascular malformation, Parkinson's disease, multiple sclerosis, and primary epilepsy); (3) history of neurosurgery prior to rupture; and (4) incomplete perioperative data.

Wang J., Li R., Li S., Ma T., Zhang X., Ren Y., Chen X, & Peng Y. (2023). Intraoperative arterial pressure and delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage after surgical clipping: A retrospective cohort study. Frontiers in Neuroscience, 17, 1064987.

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Publication 2023

Adult Anesthesia Angiography Emergencies Epilepsy Ethics Committees, Research General Anesthesia Multiple Sclerosis Neoplasms Nervous System Disorder Neurosurgical Procedures Operative Surgical Procedures Parkinson Disease Patient Admission Patients Prognosis Punctures, Lumbar Subarachnoid Hemorrhage, Aneurysmal Surgical Clips Vascular Malformations X-Ray Computed Tomography

Exclusion Criteria for Autoimmune Disorders

Patients with tumors, previously diagnosed autoimmune diseases (such as Takayasu arteritis and antiphospholipid syndrome), immunodeficiency diseases, and congenital vascular malformations (Moyamoya disease, etc.) were excluded.
This study was performed in compliance with the Helsinki Declaration. The Ethical Principles for Medical Research Involving Human Subjects were approved by the Ethics Committee at Beijing Children's Hospital, Capital University of Medical Science. During admission, informed consent was obtained for the patients' clinical records in future studies. The data were accessed anonymously and analyzed statistically.

Chen L., Yin J., Liu X., Liu J., Xu B, & Shen K. (2023). Thromboembolic complications of Mycoplasma pneumoniae pneumonia in children. The Clinical Respiratory Journal, 17(3), 187-196.

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Publication 2023

Antiphospholipid Syndrome Autoimmune Diseases Blood Vessel Congenital Abnormality Ethics Committees Immunologic Deficiency Syndromes Moyamoya disease 1 Neoplasms Patients Takayasu Arteritis Vascular Malformations

Vascular Malformation Classification Protocol

2018 ISSVA classification was used to categorize patient groups (1 ). Vascular malformations were categorized as arteriovenous malformation (AVM), capillary malformation (CM), venous malformation (VM), lymphatic malformation (LM), lymphedema, and overgrowth syndrome. Overgrowth syndrome included specific diagnoses of Klippel-Trenaunay syndrome (KTS), Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevis, Spinal/Skeletal Anomalies/Scoliosis syndrome (CLOVES), Diffuse Capillary Malformation with Overgrowth (DCMO), Parkes Weber syndrome (PWS), PTEN hamartoma of the soft tissue (PHOST), and PIK3CA-Related Overgrowth Spectrum (PROS) other than KTS or CLOVES. Patients with isolated CM with no combined overgrowth syndrome or other vascular malformation were categorized into the CM group. Five patients had multiple vascular malformations that were not a part of a syndrome (VM with CM) and were classified as VM to reduce group complexity and because of the relative severity of the conditions. Patients who presented with vascular tumors were excluded from the study to narrow the scope of the study and reduce complexity.

Mohnasky M., Brondon J., Lee S.Y, & Kim K.R. (2023). Sociodemographic characteristics of pediatric patients with vascular malformations: Results of a single site study. Frontiers in Pediatrics, 11, 1078611.

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Publication 2023

Arteriovenous Malformation Blood Vessel Capillary Malformations caryophylli flos Congenital Abnormality Diagnosis Epidermis Hamartoma Klippel-Trenaunay-Weber Syndrome Lipoma Lymphatic Abnormalities Lymphedema Multiple Abnormalities Neoplasms, Vascular Tissue Patient Isolation Patients PIK3CA protein, human PTEN protein, human Scoliosis Skeleton Sturge-Weber Syndrome Syndrome Tissues Vascular Malformations Veins

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More about "Vascular Malformations"

Vascular Abnormalities, Vascular Lesions, Hemangiomas, Venous Malformations, Arteriovenous Malformations, AVM, Lymphatic Malformations, LM, Capillary Malformations, CM, Angiomas, Birthmarks, Vascular Birthmarks, Vascular Tumors, Blood Vessel Disorders, Vascular Deformities, Vascular Anomalies, Vascular Dysplasias, Vascular Growths, Vascular Birthmarks, Vascular Malformation Syndrome, VMS, Vascular Malformation Diseases, VMD, Angiodysplasia, Vascular Hamartomas, Vascular Tumors, Vascular Anomaly, Vascular Malformation.
These congenital abnormalities can affect blood vessels, lymphatic vessels, or a combination, and can occur in any part of the body.
Proper diagnosis using techniques like Cell-Free DNA BCT tubes, Definition Flash, SPSS software for Windows (version 21.0), Artis zee biplane, Ab108525, Allura FD20, Signa MRI, BX43 light microscope, and Axio Scope A1 microscope is crucial for effective management and to prevent complications.
Active research is underway to better understand the underlying causes, optimal treatment approaches, and long-term outcomes for these complex vascular disorders.