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> Disorders > Congenital Abnormality > Renal Agenesis, Unilateral

Renal Agenesis, Unilateral

Renal Agenesis, Unilateral is a congenital anomaly characterized by the complete absence of one kidney.
This condition can occur sporadically or as part of a genetic syndrome.
It is often asymptomatic, but may be associated with increased risk of urinary tract infections, hypertension, and other complications.
Proper diagnosis and management are crucial to prevent potential health issues.
PubCompare.ai's AI-driven platform can help researchers optimize their protocols for studying this condition, by providing access to relevant literature, preprints, and patents, and enabling comparative analysis to identify the most effective approaches.

Most cited protocols related to «Renal Agenesis, Unilateral»

1
Cohort Study of Korean CKD Patients
Each participating center will enroll approximately 250 consecutive individuals over a 5-year period from 2011 until 2015, totaling 2,450 adult patients with CKD who provide written informed consent. The participating individuals will be monitored for approximately 10 years until death or until ESRD occurs.
The KNOW-CKD will enroll ethnic Korean patients with CKD who range in age between 20 years and 75 years. The CKD stages from 1 to 5 (predialysis), based on the eGFR, is calculated using the four-variable Modification of Diet in Renal Disease (MDRD) equation as follows:
eGFR (ml/min per 1.73 m2) = 175 × [serum Cr (mg/dl)] -1.154 × [age]-0.203 × [0.742 if female] × [1.212 if black], using serum creatinine concentrations measured at a central laboratory and an assay traceable to the international reference material [12 (link)].
Excluded subjects are those who 1) are unable or unwilling to give written consent, 2) have previously received chronic dialysis or organ transplantation, 3) have heart failure (NYHA class 3 or 4) or liver cirrhosis (Child-Pugh class 2 or 3), 4) have a past or current history of malignancy, 5) are currently pregnant, or 6) have a single kidney due to trauma or kidney donation.
We defined and allocated the specific causes of the CKD into four subgroups: glomerulonephritis (GN), diabetic nephropathy (DN), hypertensive nephropathy (HTN), and polycystic kidney disease (PKD). The definition of the subgroup is defined by the pathologic diagnosis, in the event that the biopsy result is available. Otherwise, the subgroup classification depends on the clinical diagnosis. GN is defined by the presence of glomerular hematuria or albuminuria with or without an underlying systemic disease causing glomerulonephritis. The diagnosis of DN is based on albuminuria in a subject with type 2 diabetes mellitus and the presence of diabetic retinopathy. HTN is defined by the patient’s hypertension history and the absence of a systemic illness associated with renal damage. Unified ultrasound criteria [13 (link)] will be used to diagnose PKD. The other causative diseases will be categorized as ‘unclassified’.
Oh K.H., Park S.K., Park H.C., Chin H.J., Chae D.W., Choi K.H., Han S.H., Yoo T.H., Lee K., Kim Y.S., Chung W., Hwang Y.H., Kim S.W., Kim Y.H., Kang S.W., Park B.J., Lee J, & Ahn C. (2014). KNOW-CKD (KoreaN cohort study for Outcome in patients With Chronic Kidney Disease): design and methods. BMC Nephrology, 15, 80.
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Publication 2014
Adult Biological Assay Biopsy Child Creatinine Diabetes Mellitus, Non-Insulin-Dependent Diabetic Nephropathy Diabetic Retinopathy Diagnosis Dialysis Diet EGFR protein, human Glomerulonephritis Heart Failure Hematuria High Blood Pressures Hypertensive Nephropathy Kidney Kidney Diseases Kidney Failure, Chronic Kidney Glomerulus Koreans Liver Cirrhosis Malignant Neoplasms Organ Transplantation Patients Polycystic Kidney Diseases Renal Agenesis, Unilateral Serum Ultrasonics Woman Wounds and Injuries
2
Renal Perfusion and Function Assessment by MDCT
Single-kidney volume, regional perfusion, RBF, and GFR were then evaluated using multi-detector computerized-tomography (MDCT, SOMOTOM Definition-64; Siemens, Forcheim, Germany), and again after a 10-min suprarenal arterial infusion of acetylcholine (Ach, 5 mg/kg/min). Ach induces endothelium-dependent microvascular vasodilation and diuresis, thereby increasing RBF and GFR18 (link). MDCT images were analyzed with Analyze™ (Biomedical Imaging Resource, Mayo Clinic, MN). Tissue time-attenuation curves obtained in ROI selected from the aorta, renal cortex, and medulla were fitted by curve-fitting algorithms to obtain measures of renal function19 (link). Cortical and medullary volumes were calculated by planimetry, and RBF as the sum of the products of cortical and medullary perfusions and volumes. GFR was calculated from the cortical proximal-tubular curve20 (link). The degree of stenosis was assessed as the decrease in renal arterial luminal diameter and area, at its most stenotic compared to a disease-free segment, in images acquired at 6mm slice thickness and 3mm overlap, reconstructed with BioF convolution kernel. The stenosis length was measured at high-magnification using a computer-caliper program.
Eirin A., Ebrahimi B., Zhang X., Zhu X.Y., Tang H., Crane J.A., Lerman A., Textor S.C, & Lerman L.O. (2012). Changes in Glomerular Filtration Rate after Renal Revascularization Correlate with Microvascular Hemodynamics and Inflammation in Swine Renal Artery Stenosis. Circulation. Cardiovascular interventions, 5(5), 720-728.
Publication 2012
Aorta Arteries Diuresis Endothelium Kidney Cortex Medulla Oblongata Multidetector Computed Tomography Perfusion Phenobarbital Renal Agenesis, Unilateral Stenosis Tissues Vasodilation X-Ray Computed Tomography
3
Longitudinal Kidney Volume and Function in ADPKD
All patients fulfilled Ravine’s diagnostic criteria of ADPKD. One hundred and eighty-eight patients with ADPKD gave informed consent to take part in an observational clinical study protocol measuring TKV once a year with simultaneous collection of 24-h urine for determination of creatinine clearance (Ccr) and urinary protein excretion between April 2007 and July 2012. Patients with end-stage renal disease (ESRD) underwent TKV measurement only. Of 188 patients, 70 underwent TKV measurement three times or more. Two patients who received laparoscopic cyst fenestration, one patient with a ureteral stone with hydronephrosis during the study period, and three patients with baseline ESRD were excluded from analysis.
Serum creatinine was measured enzymatically. Kidney function was estimated with Ccr using 24-h urine, reciprocal creatinine and eGFR. eGFR was calculated using the following formula—eGFR (male) = 194 × Cr−1.094 × Age−0.287, and eGFR (female) = eGFR (male) × 0.739. This equation is a Japanese coefficient of the modified Isotope Dilution Mass Spectrometry−Modification of Diet in Renal Disease (IDMS–MDRD) Study [11 (link)]. The staging of kidney function is based on the Kidney Disease Outcomes Quality Initiative Clinical Practice Guidelines for CKD [12 (link)] using the final eGFR measurement.
TKV was measured by high-resolution magnetic resonance imaging (MRI) using a volumetric measurement of cross-sectional imaging, as described in the report from the CRISP study [13 (link)]. Gadolinium enhancement was not used for safety reasons. TKV was adjusted by height (ht-TKV, ml/m), body surface area (bs-TKV, ml/m2) and log-converted form (log-TKV, log[ml]). Kidney volume was measured by one radiologist (KK). Intrareader reliability was extremely high—the correlation coefficient was 0.999 for ten different single kidney volume measurements at different times when blind to first measurement. The mean of the % difference between two measurements was 0.29 ± 3.28 (SD) %.
Twenty-four-hour urinary protein excretion was expressed as the mean value of several measurements for each patient. The slopes of TKV, adjusted TKV parameters and kidney function parameters were calculated using linear regression analysis for each patient. %TKV was calculated with baseline TKV as 100 %.
The study protocol was approved by an institutional review board (09-56), and the study was conducted in accordance with the guidelines of the Declaration of Helsinki. All participants gave written informed consent to use their clinical data for medical research.
Higashihara E., Nutahara K., Okegawa T., Shishido T., Tanbo M., Kobayasi K, & Nitadori T. (2013). Kidney volume and function in autosomal dominant polycystic kidney disease. Clinical and Experimental Nephrology, 18(1), 157-165.
Publication 2013
ANP32B protein, human Blindness Body Surface Area Creatinine Cyst Diagnosis Dietary Modification EGFR protein, human Ethics Committees, Research Gadolinium Hydronephrosis Isotopes Japanese Kidney Kidney Diseases Kidney Failure, Chronic Labyrinth Fenestration Laparoscopy Males Mass Spectrometry Patients Polycystic Kidney, Autosomal Dominant Proteins Radiologist Renal Agenesis, Unilateral Safety Serum Technique, Dilution Ureterolithiasis Urine Urine Specimen Collection Woman
4
Porcine Model of Metabolic Syndrome and Renal Dysfunction
All animal procedures were approved by the Institutional Animal Care and Use Committee (approval case number: A00003694-18). Twenty-eight domestic female pigs were studied for 16 weeks (Fig. 1). At baseline, 21 pigs started a high-cholesterol/high-fructose diet (MetS)15 (link) for the entire course of the study, whereas the other seven were fed regular pig chow (Lean).
Six weeks after baseline, pigs were anesthetized with 0.25 g of IM tiletamine hydrochloride/zolazepam hydrochloride (Telazol®, Zoetis, INC, Kalamazoo, MI, USA) and 0.5 g of xylazine (Xylamed, VetOne, Manufacturer is Bimeda,-MTC Animal Health, Cambridge, ON, Canada), and maintained with intravenous ketamine (0.2 mg/kg/min, [Ketaset, Distributed by Zoetis, INC, Kalamazoo, MI, USA]) and xylazine (0.03 mg/kg/min). Unilateral RVD was induced in 14 MetS pigs by placing a local-irritant coil in the main renal artery16 (link), whereas 7 Lean and 7 MetS pigs underwent a sham procedure. In all animals randomized to receive EVs, fat tissue was collected at that time, and subsequently used to harvest autologous MSCs and isolate their EVs.
Six weeks after induction of RVD, the degree of stenosis in each animal was determined using renal angiography. In addition, MetS+RVD pigs received a single infusion of either autologous EVs (labeled with the red fluorescence dye PKH26, Sigma) or vehicle into the stenotic kidney over 5 min (n = 7 each). Two other groups of MetS and Lean pigs (n = 7 each) that underwent only sham procedures (angiography, saline infusion) served as controls.
Systemic blood samples were collected 4 weeks later for cholesterol fractions, isoprostanes (enzyme immunoassay kit), and plasma renin activity (PRA, GammaCoat kit; DiaSorin) levels. Fasting glucose and insulin levels were measured by standard procedures, and insulin resistance calculated by homeostasis model assessment of insulin resistance (HOMA-IR)15 (link). In addition, single-kidney hemodynamics and function were determined using multi-detector computed tomography (MDCT). Arterial blood pressure was measured with an intra-arterial catheter during MDCT studies.
Pigs were euthanized with an intravenous bolus of 100 mg/kg of sodium pentobarbital (Sleepaway, Fort Dodge Inc., Fort Dodge, IA, USA) a few days after MDCT studies17 (link). Kidneys were removed, dissected, and sections frozen in liquid nitrogen (and maintained at –80°C) or preserved in formalin for histology and ex-vivo studies. In addition, a lobe of kidney tissue was perfused and prepared for micro-CT studies.
Eirin A., Zhu X.Y., Jonnada S., Lerman A., van Wijnen A.J, & Lerman L.O. (2018). Mesenchymal Stem Cell-Derived Extracellular Vesicles Improve the Renal Microvasculature in Metabolic Renovascular Disease in Swine. Cell Transplantation, 27(7), 1080-1095.
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Publication 2018
Angiography Animals Arteries BLOOD Catheters Cholesterol Enzyme Immunoassay Females Fluorescent Dyes Formalin Freezing Fructose Glucose Hemodynamics Homeostasis Hypercholesterolemia Institutional Animal Care and Use Committees Insulin Insulin Resistance Irritants Isoprostanes Ketamine Ketaset Kidney Multidetector Computed Tomography Nitrogen Pentobarbital Sodium Pigs PKH 26 Plasma Renal Agenesis, Unilateral Renin Saline Solution Stenosis Sus scrofa domestica Telazol Therapy, Diet tiletamine - zolazepam Tissue, Adipose Tissues X-Ray Microtomography Xylazine
5
GFR Measurement and Exclusion Criteria in Chinese CKD Patients
A total of 7676 Chinese participants who underwent GFR measurement using 99Tcm-diathylenetriamine pentaacetic acid (99Tcm-DTPA) scintigraphy from January 2009 to March 2016 in Nanfang Hospital, China, were observed. The following exclusion criteria were used: 1) younger than 18 years old or older than 65 years old (n = 1124); 2) obstructive nephropathy (n = 4060); 3) solitary kidney or a single kidney (n = 6); 4) urinary inflammation (n = 58); 5) acute renal insufficiency or injury (n = 10); 6) any history of malignancy or kidney surgery (n = 918); 7) hyperthyroidism (n = 4); 8) use of antibacterial agents within 2 weeks (n = 145); 9) malignant hypertension (n = 44). A total of 1307 patients were screened in the preliminary study, and 11 out of 1307 patients failed to meet diagnostic criteria of CKD who were excluded from the study. Finally, a total of 1296 eligible patients were enrolled in this study. The diagnostic criteria of CKD are in accordance with the K/DOQI practice guidelines. Written informed consent was obtained from each subject prior to participation. This study was approved by the Ethics Committee of the Nanfang Hospital of Sothern Medical University.
Chi X.H., Li G.P., Wang Q.S., Qi Y.S., Huang K., Zhang Q, & Xue Y.M. (2017). CKD-EPI creatinine-cystatin C glomerular filtration rate estimation equation seems more suitable for Chinese patients with chronic kidney disease than other equations. BMC Nephrology, 18, 226.
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Publication 2017
Acids Acute Kidney Insufficiency Anti-Bacterial Agents Chinese Diagnosis Ethics Committees, Clinical Hyperthyroidism Inflammation Injuries Kidney Kidney Diseases Malignant Hypertension Malignant Neoplasms Operative Surgical Procedures Outpatients Patients Radionuclide Imaging Renal Agenesis, Unilateral Urine Youth

Most recents protocols related to «Renal Agenesis, Unilateral»

1
Retrospective Analysis of DCD Kidney Transplantation
We present a retrospective analysis of collected data. Patients who underwent their first kidney transplantation in Beijing Chaoyang Hospital from August 7, 2016 to July 30, 2018 and met the inclusion criteria were included in the study. All kidneys of DCD kidney transplantation in this study were procured from donation after citizens’ death, adhering to the guidelines of the National Program for Deceased Organ Donation in China. Data on donor characteristics, recipient characteristics, number of DGFs, and outcomes at the 3-year follow-up visit were obtained from the electronic medical records. Cohort generation is shown in Figure 1. The inclusion criteria were: (1) grafts obtained from DCD, (2) surgery performed as single-kidney transplantation for allografts with a single renal artery, and (3) recipients older than 16 years during the study period. The exclusion criteria were: (1) recipients who did not have at least 1 biomarker measured, and (2) recipients who lacked medical records for 3 years after surgery due to death or loss to follow-up. Patients were followed with blood test and urine analysis every 3 weeks for a period of 3 months, every 2 weeks thereafter until 9 months, and then monthly. DGF was defined as “dialysis is needed within 1 week after kidney transplantation,” and the diagnosis of DGF was assessed by 2 independent transplant surgeons. The eGFR was calculated using the abbreviated Modification of Diet in Renal Disease (MDRD) equation. The formula used for eGFR was as follows:
Serum creatinine reduction ratio (CRR) was defined as “the average percentage of creatinine reduction within 3 days after kidney transplantation as compared to the previous day.” The formula used for CRR was as follows:
Sun Z., Gao Z., Li X., Zheng X., Wang W, & Qiao P. (2023). Perfusate Neutrophil Gelatinase-Associated Lipocalin, Kidney Injury Molecular-1, Liver-Type Fatty Acid Binding Protein, and Interleukin-18 as Potential Biomarkers to Predict Delayed Graft Function and Long-Term Prognosis in Kidney Transplant Recipients: A Single-Center Retrospective Study. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 29, e938758-1-e938758-11.
Publication 2023
Allografts Biological Markers Creatinine Diagnosis Dialysis Diet Donors EGFR protein, human Grafts Hematologic Tests Kidney Diseases Kidney Transplantation Operative Surgical Procedures Organ Transplantation Patients Renal Agenesis, Unilateral Renal Artery Serum Surgeons Transplantation Urinalysis
2
Kidney Disease Transcriptomics Database
A single-cell sequencing database for kidney disease called the Kidney Integrative Transcriptomics (K.I.T.) database was developed by Ben Humphrey’s lab at Washington University (http://humphreyslab.com/SingleCell/) (20 (link)). To explore the distribution of hub genes in cell groups, we applied the database for analysis and visualization of the results. In one of them, we used single nucleus RNA sequencing data from diabetic nephropathy that was initially taken from the GSE131882 dataset.
Xu M., Zhou H., Hu P., Pan Y., Wang S., Liu L, & Liu X. (2023). Identification and validation of immune and oxidative stress-related diagnostic markers for diabetic nephropathy by WGCNA and machine learning. Frontiers in Immunology, 14, 1084531.
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Publication 2023
Diabetic Nephropathy Gene Expression Profiling Genes Kidney Nucleus Solitarius Renal Agenesis, Unilateral
3
Prognosis of Hypertension in Primary FSGS
The data of 118 children with primary focal segmental glomerulosclerosis admitted to the Nursing Department of West China Second Hospital from January 2012 to January 2017 were retrospectively collected. The children were divided into a hypertension group (n=48) and a control group (n=70) according to whether they had hypertension, and were followed up for 5 years to compare the difference in prognosis between the two groups. The inclusion criteria were as follows: (I) primary focal segmental glomerulosclerosis diagnosed by renal biopsy; (II) aged 3–17 years; and (III) complete clinical medical records. The exclusion criteria were as follows: (I) lost to follow-up; (II) secondary infection; (III) malignant tumor; (IV) solitary kidney; (V) diabetes nephropathy, immunoglobulin A nephropathy, membranous nephropathy, lupus nephritis, purpura nephritis, and other nephropathies; (VI) secondary focal segmental glomerulosclerosis; and (VII) cases in which end-stage renal disease had been diagnosed. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). This study was approved by the Ethics Committee of the Nursing Department of West China Second Hospital (No. 2022KY-0098), and the requirement for the patients’ written informed consent for this retrospective clinical study was waived.
Huang L, & Peng W. (2023). Effect of hypertension on the long-term prognosis of children with primary focal segmental glomerulosclerosis-a retrospective cohort study. Translational Pediatrics, 12(2), 155-161.
Publication 2023
Biopsy Child Diabetic Nephropathy Ethics Committees, Clinical Glomerulosclerosis, Focal High Blood Pressures IGA Glomerulonephritis Kidney Kidney Diseases Kidney Failure, Chronic Lupus Nephritis Malignant Neoplasms Membranous Glomerulonephritis Nephritis Patients Prognosis Purpura Renal Agenesis, Unilateral Secondary Infections
4
Kidney Transplant Outpatient Clinic Study
Through the convenience sampling method, patients who were revisited in the kidney transplant outpatient clinic of the First Affiliated Hospital of University of science and technology of China were selected as subjects from October 2020 to April 2021. Based on Kendall’s proposal that the sample size of studies on variables influencing factors is at least 5 to 10 times the number of variables, a total of 21 variables in this study, calculated according to the sample size is 10 times the number of variables, this study needed at least 210 patients. There were 228 KTRs who volunteered to participate in the study, and those with incomplete information were excluded, resulting in 215 participants. The participants were recipients of single-kidney transplants. Exclusion criteria were: (1) recipients of multi-organ transplants, (2) patients with language disorders, (3) patients with cognitive impairment, (4) daily energy intake exceeded the usual permissible ranges of 500 to 3500 kcal/d for women and 800 to 4000 kcal/day for men.
Zhang H., Shi K., Yuan L., Guan X., Yin H., Zhao W., Zhou X, & Chu A. (2023). Association Between Dietary Quality and Serum Cystatin C in Kidney Transplant Recipients Based on Chinese Diet Balance Index 2016 (DBI-16). Annals of Transplantation, 28, e939149-1-e939149-9.
Publication 2023
Disorders, Cognitive Kidney Transplantation Language Disorders Patients Renal Agenesis, Unilateral Transplant Recipients Woman
5
Ureteral Stone Management Protocol
Inclusion criteria: ureteral stone greater than 6 mm in diameter, age ≥ 18 years, body mass index (BMI) < 30 kg/m2, ureteral stone density < 1000 Hounsfield’s units (HU), and skin-to-stone distance 11 cm. Stones with a poor probability of spontaneous passage, chronic pain despite adequate analgesia, persistent obstruction or stone development, recurrent or first-time stone formers were both eligible, and urine cultures were negative.
Exclusion criteria: pregnancy; uncontrolled urinary tract infection; coagulopathy; arterial aneurysm in the vicinity of the stone; severe skeletal malformations, which prevent targeting of the stone; patients with JJ-stent/nephrostomy insertion before treatment for the resolution of urinary tract obstruction; multiple or bilateral ureteral stones; solitary kidney; anatomical obstruction distal to the stone or congenital genitourinary anomaly (such as horseshoe kidney or ileal conduit); transplanted kidney; renal insufficiency (elevated creatinine).
After counseling the patients about the benefits and drawbacks of SWL, the decision was made based on their preferences. After the patients gave their informed consent, it was carried out by senior, experienced doctors.
Na L., Li J., Pan C., Zhan Y, & Bai S. (2023). Development and validation of a predictive model for major complications after extracorporeal shockwave lithotripsy in patients with ureteral stones: based on a large prospective cohort. Urolithiasis, 51(1), 42.
Publication 2023
Aneurysm Arteries Blood Coagulation Disorders Calculi Chronic Pain Congenital Abnormality Creatinine Horseshoe Kidney Ileal Conduit Index, Body Mass Kidney Management, Pain Nephrostomy Patients Physicians Pregnancy Renal Agenesis, Unilateral Renal Insufficiency Skeleton Skin Stents Ureterolithiasis Urinary Tract Urinary Tract Infection Urine Urogenital Abnormalities

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More about "Renal Agenesis, Unilateral"

Renal Agenesis, Unilateral is a congenital abnormality characterized by the complete absence of one kidney.
This condition, also known as congenital renal agenesis or unilateral renal agenesis, can occur randomly or as part of a genetic syndrome.
While often asymptomatic, it may increase the risk of urinary tract infections, hypertension, and other complications.
Proper diagnosis and management are crucial to prevent potential health issues.
Researchers studying this condition can leverage PubCompare.ai's AI-powered platform to optimize their research protocols.
The platform provides access to relevant literature, preprints, and patents, enabling researchers to conduct comparative analysis and identify the most effective approaches.
This can be particularly useful when working with techniques and equipment like the Somatom Sensation-128 CT scanner, BD Accuri C6 flow cytometer, MATLAB software, FACSCalibur flow cytometer, GentleMACS Dissociator, fetal bovine serum (FBS), MATLAB 7.0, DNase I enzyme, Multi Tissue Dissociation Kit 2, and CryoStor CS10 cryopreservation medium.
By utilizing PubCompare.ai's platform, researchers can streamline their research process, uncover valuable insights, and advance their understanding of Renal Agenesis, Unilateral.
The platform's AI-driven capabilities can help researchers identify the most promising protocols, products, and techniques, ultimately accelerating their progress and contributing to the broader understanding of this condition.