Experiments were carried out according to National Institutes of Health Guidelines on the Use of Laboratory Animals and all procedures were approved by the Thomas Jefferson University Committee on Animal Care. A total of 497 (384 mice for MI and 113 for I/R) male 8-10 week old C57/B6 mice were used for this study. For the MI model, mice were subjected to permanent coronary artery ligation using either the new (N) method or the classical (C) method. Mice were randomly assigned to four groups: new method of MI (MI-N) or sham (S-N); classical method of MI (MI-C) or sham (S-C). There were 119 mice used for survival study. Some of the mice survived at the end of 28 days were also used for echocardiographic, hemodynamic and infarct size studies as indicated in each study. The rest of 232 mice survived from all kinds of 265 procedures (33 mice died) were used for 24h infarct size measurement (32 mice), Masson's trichrome stain (18 mice), arrhythmia analysis (28 mice), myeloperoxidase (MPO, 81) and TNFα (73) assays. In I/R model, mice were subjected to 30 min of myocardial ischemia followed by 24 hrs of reperfusion. Mice were divided into four groups also: new method of I/R (I/R-N, n=41) or sham (SI/R-N, n=16), classical method of I/R or sham I/R (I/R-C, n=40, SI/R-C, n=16, respectively). All animals were monitored after the surgery and received one dose (0.3mg/kg) of buprenophine within 6 hours post surgery and another dose was administered the following morning. No further analgesia was given thereafter.
>
Disorders
>
Disease or Syndrome
>
Cardiac Arrhythmia
Cardiac Arrhythmia
Cardiac arrhythmia refers to an abnormal heart rhythm, characterized by irregularities in the electrical activity of the heart.
This condition can manifest in various forms, including atrial fibrillation, ventricular tachycardia, and bradycardia, among others.
Cardiac arrhythmias can have serious implications, potentially leading to reduced blood flow, heart failure, and even sudden cardiac death if left untreated.
Understanding and effectively managing cardiac arrhythmias is crucial for maintaining cardiovascular health.
PubCompare.ai offers a powerful tool to optimize cardiac arrhythmia research, enabling users to easily locate relevant protocols from literature, preprints, and patents, while leveraging AI-driven comparisons to identify the best protocols and products.
This innovative tool enhances reproducibility and accuracy in cardiac arrhythmia studies, allowing researchers to experience the future of research today and advance the field of cardiovascular medicine.
This condition can manifest in various forms, including atrial fibrillation, ventricular tachycardia, and bradycardia, among others.
Cardiac arrhythmias can have serious implications, potentially leading to reduced blood flow, heart failure, and even sudden cardiac death if left untreated.
Understanding and effectively managing cardiac arrhythmias is crucial for maintaining cardiovascular health.
PubCompare.ai offers a powerful tool to optimize cardiac arrhythmia research, enabling users to easily locate relevant protocols from literature, preprints, and patents, while leveraging AI-driven comparisons to identify the best protocols and products.
This innovative tool enhances reproducibility and accuracy in cardiac arrhythmia studies, allowing researchers to experience the future of research today and advance the field of cardiovascular medicine.
Most cited protocols related to «Cardiac Arrhythmia»
Animals
Animals, Laboratory
Artery, Coronary
Biological Assay
Buprenorphine
Cardiac Arrhythmia
Echocardiography
Hemodynamics
Infarction
Ligation
Males
Management, Pain
Mice, House
Myocardial Ischemia
Operative Surgical Procedures
Peroxidase
Reperfusion
trichrome stain
Tumor Necrosis Factor-alpha
African American
Cardiac Arrhythmia
Cardiopulmonary Exercise Test
Cardiovascular System
Clinic Visits
Congestive Heart Failure
Ethics Committees
Ethics Committees, Research
Ethnicity
Heart
Ischemia
Medical Devices
Patients
Pharmaceutical Preparations
Physical Examination
Rate, Heart
Therapeutics
Ventricular Ejection Fraction
Atrial Fibrillation
Atrial Flutter
Cardiac Arrhythmia
Crohn Disease
Diabetic Ketoacidosis
Fingers
Inflammatory Bowel Diseases
Injuries
Parent
Phenotype
Ulcerative Colitis
Addictive Behavior
Alcoholic Beverages
Angina Pectoris
Arm, Upper
Buffaloes
Cardiac Arrhythmia
Central Nervous System Stimulants
Cerebrovascular Accident
Coagulants
Cocaine
Contraceptives, Oral
CYP2A6 protein, human
Epistropheus
Grafts
High Blood Pressures
Inhaler
Kidney
Liver Diseases
Major Depressive Disorder
Malignant Neoplasms
Mental Disorders
Mental Health
Methamphetamine
Monoamine Oxidase Inhibitors
Monoxide, Carbon
Myocardial Infarction
Nicotine
Nicotine Transdermal Patch
Opiate Alkaloids
Pharmaceutical Preparations
Placebos
Pregnancy
Safety
Substance Abuse
Tobacco Use Disorder
Tricyclic Antidepressive Agents
Varenicline
Acute Coronary Syndrome
Cardiac Arrhythmia
Cardiomyopathies
Cardiovascular System
Cerebrovascular Disorders
Diabetes Mellitus
Dyslipidemias
Heart
Heart Diseases
Hemodynamics
High Blood Pressures
Outpatients
Patients
Peripheral Vascular Diseases
Physicians
Woman
Most recents protocols related to «Cardiac Arrhythmia»
The outcome was a composite of all-cause mortality or major cardiac events within 30 days of the index surgical procedure, which included acute myocardial infarction (AMI) and non-fatal ventricular arrhythmias identified using validated algorithms (Supplementary Table 2 ). This composite outcome is similar to other postoperative risk tools and was informed by perioperative cardiac risk assessment guidelines [11 (link)].
Full text: Click here
Cardiac Arrhythmia
Health Risk Assessment
Heart
Heart Ventricle
Myocardial Infarction
Surgical Procedure, Cardiac
Following popliteal access (required with the use of ultrasound guidance) or femoral access with a 10-F sheath under local anaesthesia and strict sterile techniques, RT using a ZelanteDVT catheter or a Solent catheter was performed for pharmacomechanical thrombus fragmentation, suction or aspiration. First, the RT catheter was slowly advanced through the thrombotic segment (only submerged in vessel diameter estimated > 6 mm). For patients without contraindications of thrombolysis, 3 mg of rt-PA [total injected volume of 50 ml] was intraclot injected under the Power Pulse® model. After 20 minutes of dwell time, with the pump unit active during slow catheter passages (3 mm/s to 5 mm/s), runs were performed across the thrombotic segment in a distal-to-proximal or adverse direction under fluoroscopic guidance. Each device activation run lasted at less than 20 seconds with breaks of 30 seconds between the runs to avoid arrhythmia, and the total run times were monitored and kept no more than 240 seconds.
Full text: Click here
Alteplase
Blood Vessel
Cardiac Arrhythmia
Catheters
Femur
Fibrinolytic Agents
Fluoroscopy
Local Anesthesia
Medical Devices
Neoplasm Metastasis
Patients
Pulse Rate
Sterility, Reproductive
Suction Drainage
Thrombus
Ultrasonography
Technical success was defined as the successful use of AngioJet RT. Thrombus score was calculated through venography imaging by two experienced interventional physicians independently depending on pre-RT, at the completion of RT or post-CDT, by adding the scores of six vein segments (common iliac vein, external iliac vein, common femoral vein, proximal and distal segments of femoral vein, and popliteal vein). Thrombus scores were 0 when the vein was patent and completely free of thrombus, 1 in condition of a partially occluded vein, and 2 in condition of a completely occluded vein (i.e., vein lumen completely occluded with massive thrombus). The score was calculated for each segment, resulting in possible total thrombus scores. The thrombus removal rate was calculated as follows: [total pre-RT scores - total completion of RT (or total post-CDT scores)]/total pre-RT scores × 100%. Thrombus removal grades were evaluated as grade III (100% thrombus removal rate with no residual clots), grade II (50–99% thrombus removal rate), and grade I (< 50% thrombus removal rate). Thrombus removal grades II and III (i.e., ≥50% thrombus removal rate) were considered clinical success [10 (link)], which consisted of primary RT success and adjunctive CDT success. The primary RT (defined as patients who did not require adjunctive CDT treatment) success was classified based on preprocedural and at completion of RT thrombus scores evaluated as grade II and grade III. Adjunctive CDT (defined as patients who required adjunctive CDT treatment) success was classified based on preprocedural thrombus scores and those at the end of adjunctive CDT that were evaluated as grade II and grade III. The requirement of necessary adjunctive PTA and/or stent placement to treat coexisting stenosis to obtain sufficient flow within the same hospital stay was recorded but not considered clinical failure.
The safety outcomes consisted of procedure-related and CDT-related complications. The former included vessel perforation or damage (such as extravasation or retention of contrast agent in the vessel wall), bradycardia, arrhythmias or acute kidney injury (AKI). With adherence to the Society of Interventional Radiology (SIR) [11 (link)], the latter feature was divided into major CDT-related complications, which were defined as intracranial bleeding or bleeding severe enough to result in death, surgery, cessation of therapy, or blood transfusion, and minor complications, which were defined as less severe bleeding manageable with local compression, sheath upsizing, and/or alterations of thrombolytic agent dose and anticoagulant dose [11 (link)]. The SIR classification of complications is listed in theSupplementary Table .
The safety outcomes consisted of procedure-related and CDT-related complications. The former included vessel perforation or damage (such as extravasation or retention of contrast agent in the vessel wall), bradycardia, arrhythmias or acute kidney injury (AKI). With adherence to the Society of Interventional Radiology (SIR) [11 (link)], the latter feature was divided into major CDT-related complications, which were defined as intracranial bleeding or bleeding severe enough to result in death, surgery, cessation of therapy, or blood transfusion, and minor complications, which were defined as less severe bleeding manageable with local compression, sheath upsizing, and/or alterations of thrombolytic agent dose and anticoagulant dose [11 (link)]. The SIR classification of complications is listed in the
Full text: Click here
Anticoagulants
Blood Transfusion
Blood Vessel
Cardiac Arrhythmia
Clotrimazole
Contrast Media
Fibrinolytic Agents
Iliac Vein
Kidney Failure, Acute
Operative Surgical Procedures
Patients
Phlebography
Physicians
Retention (Psychology)
Safety
Stenosis
Stents
Therapeutics
Thrombus
Vein, Femoral
Veins
Veins, Popliteal
SNP genotypes were denoted as 0/0 for homozygous reference alleles, 0/1 for heterozygous alleles, and 1/1 for homozygous alternate alleles (0: reference allele; 1: alternate allele). Association analysis of logistic regression was performed using the Python package statsmodels (Seabold et al., 2010 ). An additive model was used for the association between the SNPs and AMD. For additive logistic regression analysis, homozygous reference alleles, heterozygous alleles, and homozygous alternate alleles were respectively defined as the values 0, 1, and 2. The clinical data mining and management of the SQL server in TCVGH was conducted using Microsoft Azure Data Studio. Patient comorbidities included hypertension (ICD-9-CM codes 401.xx—405.xx), coronary artery disease (410.xx—414.xx), cardiac dysrhythmias (427.xx, 785.0, and 785.1), cerebrovascular diseases (433.xx—438.xx), chronic respiratory diseases (490—496), and hyperlipidemia (272.x). Individuals with any comorbidity were identified through diagnoses performed during at least two ambulatory visits to TCVGH. Statistical significance was defined as a p-value < 0.05.
Survival analysis was assessed by the Kaplan–Meier estimate using the R package survival (Therneau and Grambsch, 2000 ). Observation time was defined as the period of duration from the first outpatient visit for a comorbidity to the first time receiving a diagnosis for AMD. The survival curve was plotted by the R package survminer (https://CRAN.R-project.org/package=survminer ). Log-rank tests for significant differences in survival time between the two groups were performed using the survdiff function in the survival package. A Cox proportional hazard (PH) model was used to estimate the hazard ratio (HR) using the coxph function in the survival package. For Cox PH model, homozygous reference alleles (0/0), heterozygous alleles (0/1), and homozygous alternate alleles (1/1) were respectively defined as the values 0, 1, and 2.
Survival analysis was assessed by the Kaplan–Meier estimate using the R package survival (Therneau and Grambsch, 2000 ). Observation time was defined as the period of duration from the first outpatient visit for a comorbidity to the first time receiving a diagnosis for AMD. The survival curve was plotted by the R package survminer (
Full text: Click here
Alleles
Azure A
Cardiac Arrhythmia
Cerebrovascular Disorders
Coronary Artery Disease
Diagnosis
Disease, Chronic
Genotype
Heterozygote
High Blood Pressures
Homozygote
Hyperlipidemia
Outpatients
Patients
Python
Respiration Disorders
Respiratory Rate
Single Nucleotide Polymorphism
This retrospective and cross-sectional study was conducted in Trakya University Hospital Respiratory Intensive Care Units which was approved by the Trakya University Clinical Research Ethics Committee (TÜTF-BAEK 2021/275) and the Turkish Ministry of Health (2021-06-07T10_06_44). Patients diagnosed with ARF due to lung involvement of laboratory-confirmed (RT-PCR) COVID-19 and managed with HFNC at ICU admission were included in the study between April 2020 and January 2022.
As per the Turkish Ministry of Health COVID-19 management guideline,21 HFNC is indicated for patients with persistent hypoxemia or respiratory distress symptoms under low flow oxygen therapy systems. HFNC was administered in the ICU with HI-Flow StarTM (Dragerwerk AG & Co., Germany), which is set to deliver a flow rate up to 50 l/min with FiO2 to keep the patient’s SpO2 above 90%.
If deterioration in the patient’s level of consciousness, worsening dyspnea, malign arrhythmia, or hemodynamic instability were detected or more than 60% FiO2 under 50 l/min flow rate was required to keep the patient’s PaO2/FiO2 over 150 mmHg, it was considered a treatment failure. Non-invasive ventilation (NIV) or IMV was initiated as rescue therapy.
Data were abstracted from the hospital records and nurse charts. Patients’ demographics, body mass indices, comorbidities, Charlson Comorbidity Indices,22 (link) disease severity scores [Acute Physiology and Chronic Health Assessment (APACHE),23 (link) Sequential Organ Failure Assessment (SOFA)24 (link)] and laboratory findings (hemogram, d-dimer, ferritin, C-reactive protein, procalcitonin, arterial blood gas parameters within 2 hours thereafter HFNC initiation) at ICU admission; ROX indices at initiation, 2nd, 8th, 12th, 24th and 48th hours of HFNC; and out-comes (ICU and hospital length of stay, in 28-day mortality) were recorded (Figure 2 ). ROX index was calculated using the formula (SpO2/FiO2)/respiratory rate.18 (link) Patients were excluded who were younger than 18 years old and HFNC failed within 2 hours of the therapy.
As per the Turkish Ministry of Health COVID-19 management guideline,21 HFNC is indicated for patients with persistent hypoxemia or respiratory distress symptoms under low flow oxygen therapy systems. HFNC was administered in the ICU with HI-Flow StarTM (Dragerwerk AG & Co., Germany), which is set to deliver a flow rate up to 50 l/min with FiO2 to keep the patient’s SpO2 above 90%.
If deterioration in the patient’s level of consciousness, worsening dyspnea, malign arrhythmia, or hemodynamic instability were detected or more than 60% FiO2 under 50 l/min flow rate was required to keep the patient’s PaO2/FiO2 over 150 mmHg, it was considered a treatment failure. Non-invasive ventilation (NIV) or IMV was initiated as rescue therapy.
Data were abstracted from the hospital records and nurse charts. Patients’ demographics, body mass indices, comorbidities, Charlson Comorbidity Indices,22 (link) disease severity scores [Acute Physiology and Chronic Health Assessment (APACHE),23 (link) Sequential Organ Failure Assessment (SOFA)24 (link)] and laboratory findings (hemogram, d-dimer, ferritin, C-reactive protein, procalcitonin, arterial blood gas parameters within 2 hours thereafter HFNC initiation) at ICU admission; ROX indices at initiation, 2nd, 8th, 12th, 24th and 48th hours of HFNC; and out-comes (ICU and hospital length of stay, in 28-day mortality) were recorded (
Arteries
Blood
Cardiac Arrhythmia
Consciousness
COVID 19
C Reactive Protein
Dyspnea
Ethics Committees, Research
Ferritin
fibrin fragment D
Hemodynamics
Index, Body Mass
Lung
Noninvasive Ventilation
Nurses
Patients
physiology
Procalcitonin
Respiratory Rate
Respiratory System
Reverse Transcriptase Polymerase Chain Reaction
Saturation of Peripheral Oxygen
Therapeutics
Therapies, Oxygen Inhalation
Youth
Top products related to «Cardiac Arrhythmia»
Sourced in United States, Austria, Japan, Cameroon, Germany, United Kingdom, Canada, Belgium, Israel, Denmark, Australia, New Caledonia, France, Argentina, Sweden, Ireland, India
SAS version 9.4 is a statistical software package. It provides tools for data management, analysis, and reporting. The software is designed to help users extract insights from data and make informed decisions.
Sourced in United States, Austria, Japan, Belgium, United Kingdom, Cameroon, China, Denmark, Canada, Israel, New Caledonia, Germany, Poland, India, France, Ireland, Australia
SAS 9.4 is an integrated software suite for advanced analytics, data management, and business intelligence. It provides a comprehensive platform for data analysis, modeling, and reporting. SAS 9.4 offers a wide range of capabilities, including data manipulation, statistical analysis, predictive modeling, and visual data exploration.
Sourced in United States, Austria, Canada, Belgium, United Kingdom, Germany, China, Japan, Poland, Israel, Switzerland, New Zealand, Australia, Spain, Sweden
Prism 8 is a data analysis and graphing software developed by GraphPad. It is designed for researchers to visualize, analyze, and present scientific data.
Sourced in United States, Sao Tome and Principe
CARTO 3 is a medical device designed for advanced cardiac mapping and visualization. It provides healthcare professionals with a platform to generate and analyze detailed 3D maps of the heart's electrical activity.
Sourced in Australia, United States, United Kingdom, New Zealand, Germany, Japan, Spain, Italy, China
PowerLab is a data acquisition system designed for recording and analyzing physiological signals. It provides a platform for connecting various sensors and transducers to a computer, allowing researchers and clinicians to capture and analyze biological data.
Sourced in Australia, United States, United Kingdom, New Zealand, Germany, Japan, Canada
The PowerLab system is a versatile data acquisition hardware platform designed for laboratory research and teaching applications. It offers a range of input channels and signal conditioning options to accommodate a variety of experimental setups. The PowerLab system is capable of recording and analyzing various physiological signals, enabling researchers to capture and study relevant data for their studies.
Sourced in United States
The Thermocool SmartTouch is a medical device used for diagnostic and treatment procedures. It provides precise temperature monitoring and control functionality to medical professionals.
Sourced in United States, Austria, Japan, Belgium, Brazil, United Kingdom, Cameroon
SAS software version 9.4 is a comprehensive data analysis and management solution. It provides advanced statistical and analytical capabilities for organizations to manage, analyze, and report on their data. The software includes a range of tools and features to support various data-driven tasks, such as data manipulation, statistical modeling, and predictive analytics.
Sourced in United States
The Reveal LINQ is a cardiac monitoring device designed to detect and record heart rhythm abnormalities. It is an insertable cardiac monitor that is placed under the skin during a minor surgical procedure.
More about "Cardiac Arrhythmia"
Cardiac arrhythmia, irregular heart rhythm, abnormal electrical activity, atrial fibrillation, ventricular tachycardia, bradycardia, SAS 9.4, Prism 8, CARTO 3, PowerLab, PowerLab system, Thermocool SmartTouch, Reveal LINQ, cardiovascular health, heart failure, sudden cardiac death, reproducibility, accuracy, PubCompare.ai, research optimization, protocols, literature, preprints, patents, AI-driven comparisons, cardiovascular medicine.
Cardiac arrhythmias are a diverse group of conditions characterized by irregularities in the heart's electrical signaling, leading to abnormal heart rhythms.
These can manifest in various forms, such as atrial fibrillation, ventricular tachycardia, and bradycardia, among others.
Untreated, cardiac arrhythmias can have serious consequences, including reduced blood flow, heart failure, and even sudden cardiac death.
Effectively managing and understanding cardiac arrhythmias is crucial for maintaining cardiovascular health.
PubCompare.ai is a powerful tool that can optimize cardiac arrhythmia research by enabling users to easily locate relevant protocols from literature, preprints, and patents, while leveraging AI-driven comparisons to identify the best protocols and products.
This innovative tool enhances reproducibility and accuracy in cardiac arrhythmia studies, allowing researchers to experience the future of research today and advance the field of cardiovascular medicine.
Whether you're using SAS 9.4, Prism 8, CARTO 3, PowerLab, Thermocool SmartTouch, or Reveal LINQ, PubCompare.ai can help you streamline your cardiac arrhythmia research and unlock new insights to improve patient outcomes.
Cardiac arrhythmias are a diverse group of conditions characterized by irregularities in the heart's electrical signaling, leading to abnormal heart rhythms.
These can manifest in various forms, such as atrial fibrillation, ventricular tachycardia, and bradycardia, among others.
Untreated, cardiac arrhythmias can have serious consequences, including reduced blood flow, heart failure, and even sudden cardiac death.
Effectively managing and understanding cardiac arrhythmias is crucial for maintaining cardiovascular health.
PubCompare.ai is a powerful tool that can optimize cardiac arrhythmia research by enabling users to easily locate relevant protocols from literature, preprints, and patents, while leveraging AI-driven comparisons to identify the best protocols and products.
This innovative tool enhances reproducibility and accuracy in cardiac arrhythmia studies, allowing researchers to experience the future of research today and advance the field of cardiovascular medicine.
Whether you're using SAS 9.4, Prism 8, CARTO 3, PowerLab, Thermocool SmartTouch, or Reveal LINQ, PubCompare.ai can help you streamline your cardiac arrhythmia research and unlock new insights to improve patient outcomes.