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Goiter

Goiter refers to an enlagerment of the thyroid gland, often resulting from iodine deficiency or other underlying conditions.
This condition can lead to a variety of symptoms, including a visible swelling in the neck, breathing difficulties, and changes in hormone production.
Researchers can utilize PubCompare.ai's AI-driven platform to optimize their goiter studies, locating the best research protocols from literature, preprints, and patents through intelligent comparisons.
This innovative tool can enhance reproducibility and accuracy in goiter research, supporting advancements in diagnosis, treatment, and management of this common thyroid disorder.

Most cited protocols related to «Goiter»

In Beijing, 15 community health centers were selected by multistage random sampling approach. People with type 2 diabetes (aged 20–80 years) who had lived in the community over 5 years were recruited between August 2008 and July 2009. A total of 3,182 diabetic subjects with measurement of NC were available for analysis. People with severe disabilities, hepatic failure, renal failure, schizophrene, or goiter were excluded. Written informed consent was obtained from all participants.
Past medical history was determined with a standardized questionnaire. Blood pressure was measured twice after each subject had been seated for 10 min. The average was used for analysis. Waist circumference (WC) was measured at the level midway between the lower rib margin and the iliac crest. NC was measured with head erect and eyes facing forward, horizontally at the upper margin of the laryngeal prominence (Adam's apple). Fasting glucose and lipid profiles were determined using an autoanalyzer.
Overweight was defined as BMI ≥24 kg/m2, central obesity was defined as WC ≥85 cm for men and ≥80 cm for women (5 –6 ). MS was defined according to the Chinese Diabetes Society definition (7 ).
Receiver operating characteristic (ROC) curve analyses were performed using SPSS 11.5 software. The Youden index, defined as “sensitivity + specificity − 1,” was used to determine the optimal NC cutoff points.
Publication 2010
Blood Pressure Chinese Costal Arch Diabetes Mellitus Diabetes Mellitus, Non-Insulin-Dependent Disabled Persons Eye Glucose Goiter Head Hepatic Insufficiency Iliac Crest Kidney Failure Larynx Lipids Schizophrenia Waist Circumference Woman
The 6,800 affected individuals were recruited as part of the Juvenile Diabetes Research Foundation/Wellcome Trust (JDRF/WT) Diabetes and Inflammation Laboratory's JDRF/WT British case collection (Genetic Resource Investigating Diabetes), which is a joint project between the University of Cambridge Departments of Paediatrics at the Addenbrooke's Hospital and Medical Genetics at the Cambridge Institute for Medical Research. Most affected individuals were <16 years of age at the time of collection; all were under age 17 years at diagnosis and all resided in Great Britain. The 7,000 control samples were obtained from the British 1958 Birth Cohort (B58C), an ongoing study of all people born in Great Britain during one week in 1958 (see URL below). All cases and control were of self-reported white ethnicity, with the exception of 18 cases for whom the WTCCC study found genotype evidence for non-white ethnic group status1 .
All families were of reported or self-reported white ethnicity and of European descent, with two parents and at least one affected child. The family collection consisted of 458 families from the UK Diabetes UK Warren 1 repository, 328 families from USA Human Biological Data Interchange, 250 families from Northern Ireland, 951 Finnish families, 360 Norwegian families, 412 Romanian families and 80 families from Yorkshire, UK (Supplementary Table 6). All DNA samples were collected after approval from the relevant research ethics committees, and written informed consent was obtained from the participants or their guardians.
As part of the AITD Autoimmune thyroid disease (AITD) UK National Collection, 2,200 unrelated, reported white individuals with Graves' disease were recruited. Participants were recruited from centers across the UK, including Birmingham, Bournemouth, Cambridge, Cardiff, Exeter, Leeds, Newcastle and Sheffield (Supplementary Table 6). Affected individuals were defined by the presence of biochemical hyperthyroidism together with at least one of the following: (i) a diffuse goiter on a scan, (ii) positive autoantibodies to the thyrotropin receptor (TSHR), (iii) diffuse goiter on palpation, along with thyroglobulin or thyroid peroxidase autoantibodies or (iv) thyroid eye disease (NOSPECS classification score of 2–6).
Publication 2007
Autoantibodies Biopharmaceuticals Birth Cohort Child Childbirth Diabetes Mellitus Diabetes Mellitus, Insulin-Dependent Diagnosis Ethics Committees, Research Ethnicity Europeans Genotype Goiter Graves Disease Homo sapiens Hyperthyroidism Inflammation Iodide Peroxidase Joints Legal Guardians Long-Acting Thyroid Stimulator Palpation Parent Radionuclide Imaging Thyroglobulin Thyroid-Associated Ophthalmopathy Thyroid Diseases White Person
Thyroid sonography was performed by using one of three scanners (GE logic 9, Philips HDI 5000, Philips IU 22) with a 5–12 MHz linear transducer. Thyroid preset was applied. All patients were scanned in a supine position with neck hyperextension. Sonograms of thyroid including cervical lymph nodes were obtained in transverse, longitudinal, and multiple oblique planes. According to the preliminary impressions of original sonography report of the PTL patient, the PTL sonography appearances in present study were divided into either the diffuse type or the non-diffuse type. In cases of diffuse type, bilateral thyroid gland was diffusely involved by neoplastic tissue without any discrete lesion (PTL or non-PTL) that was sonographically distinguishable from the adjacent parenchyma. In cases of non-diffuse type, neoplastic tissue focally involved the thyroid gland, in which one or multiple discrete lesion(s) nodularly or patchily present in thyroid. Sonographic features including thyroid size, thyroid background echotexture, lesion size, echogenecity, calcification, vascularity, cervical lymphadenopathy of each type were retrospectively determined by two radiologists (Y.X and YX.J) in consensus manner. Each of the radiologists had over 1500 cases thyroid sonography experience.
Goiter was determined as the presentation of a thyroid with the craniocaudal diameter more than 6.0 cm or the anteroposterior diameter more than 2.0 cm. The echotexture of background thyroid gland was determined as homogeneous or heterogeneous. Lesion size was analyzed as the greatest diameter of each nodule. Echogenecity that were lower than the degree of the neck strap muscle, that were between the muscle and the thyroid gland, and that were higher or equivalent to the thyroid gland were determined as markedly hypoechoic, hypoechoic, and hyperechoic or isoechoic, respectively. Calcification information such as microcalcification and macrocalcification was recorded. Dense hyperechoic with posterior shadowing was defined as macrocalcification, while tiny dot-like hyperechoic without posterior shadowing was defined as microcalcification. Compared with adjacent non-lymphomatous tissue, the vascularity was classified as avascularity (no blood flow), normal vascularity (similar to adjacent tissue), or increased vascularity (more than adjacent tissue). Lymphadenopathy was identified as lymph nodes presenting with measurements of 5 mm or greater in the short axis, and the absence of a hyperechoic hilum, a heterogeneous echotexture, chaotic vascularity, calcification, or a cystic change. In the cases of diffuse type, vasucarity were not evaluated because no non-lymphomatous tissue was available for comparison.
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Publication 2014
Blood Circulation Blood Vessel Calcinosis Cyst Epistropheus Genetic Heterogeneity Goiter Lymphadenopathy Lymphoma Microcalcification Muscle Tissue Neck Neck Muscles Neoplasms Nodes, Lymph Patients Radiologist Thyroid Gland Tissues Transducers Ultrasonography
Between July 2002 and October 2003 routine results of serum TSH, fT3, and fT4 were collected from existing laboratory data of 2,194 serum samples from a hospital based population of children aged 1 day – 18 years. The in- and out clinic patients had been admitted to the pediatric department of the Medical University Innsbruck for a variety of reasons. Subjects were sub-grouped according to age, ranging from 1 day to 1 month, 1 – 12 months, and 1 – 5, 6 – 10, 11 – 14, and 15 – 18 years, respectively. Classification of age groups was primarily based on those of previously published studies to facilitate reliable comparison of the results, and also specifically according to the age-related course of the obtained values. Two or more samples were taken from 410 patients, 1,085 patients had only one serum sample taken. All procedures were done in accordance with the Declaration of Helsinki.
Data were collected routinely within the setting of clinical practice according to standard procedures. The parents of the children gave their informed consent. No further measures were taken beyond clinical practice.
Classification of the patients in diagnostic categories was done using the International Classification of Diseases (ICD-10) codes. Children with conditions or concomitant medications likely to affect thyroid function were excluded from the reference group [8 (link)]. Also patients with eating disorders, with pituitary disease or chromosomal anomalies were not included in the analysis. Patients presenting a deviation in height or weight were identified at the clinical examination and classified as normal variants of growth (ICD E34.3 and E34.4) including familial or constitutional factors. All diagnostic groups have been included in a separate Excel file (additional material). Each diagnostic group was statistically evaluated in comparison to Z00.0 (n = 414; general examination and investigation of persons without complaint and reported diagnosis) using the one way ANOVA post-hoc analyses (data not shown). Serum samples from patients having the following ICD-10 diagnostic codes indicating thyroid dysfunction were excluded a-priori (n = 665): Congenital hypothyroidism with and without diffuse goiter (E03.0, E03.1), other non toxic goiter (E04.0 – E04.9), dyshormonogenetic goiter (E07.1), thyrotoxicosis (E05.0 – E05.9), autoimmune thyroiditis and unspecified thyroiditis (E06.3, E06.9), any neoplasm of the thyroid gland (C73 and D44.0), post procedural hypothyroidism (E89.0), and other specified or unspecified hypothyroidism (E03.8, E03.9).
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Publication 2008
Age Groups Child Congenital Hypothyroidism Diagnosis Disorder, Chromosomal Eating Disorders Goiter Hashimoto Disease Hypothyroidism neuro-oncological ventral antigen 2, human Outpatients Parent Patients Pharmaceutical Preparations Physical Examination Pituitary Diseases Post Technique Serum Thyroid Gland Thyroiditis Thyroid Neoplasm Thyrotoxicosis
We analysed the prevalence of thyroid cancer using models for the binomial odds (Breslow and Day, 1987 ). The dose categories were selected to evenly distribute cases. We fitted an EOR model to continuous doses to estimate the EOR/Gy where the disease odds is: where d represents radiation dose, x and z are covariate vectors representing confounding and effect modification variables, respectively, and α, β and γ are unknown parameters.
Past iodine deficiency was evaluated using proxy indicators, including place of residence at the time of the accident, self-reported history of diffuse goiter, diffuse goiter diagnosed during screening and enlarged thyroid (thyroid volume>18 ml for women and >25 ml for men) (Rasmussen et al, 2002 (link)). In addition, we evaluated gender, age at the time of the accident, and oblast of residence, urban/rural status and age at screening, history of nodular goiter, and urinary iodine concentration as risk factors and/or possible modifiers of the dose–response. We retained potential confounding variables in the model if they significantly improved the model fit or if the estimate of the EOR changed by more than 10%.
We analysed data using the EPICURE software package (Preston et al, 1993 ). All statistical tests were two-sided with a specified type I error of 0.05, and 95% CIs were estimated by maximum likelihood procedures. Linear trend test was based on the means of the dose categories.
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Publication 2010
Accidents Carcinoma, Thyroid Cloning Vectors Goiter Iodine Nodular Goiter Radiation Thyroid Gland Urine Woman

Most recents protocols related to «Goiter»

A retrospective cohort study was carried out between January 1, 2010, and July 31, 2020, at Shanghai Fifth People's Hospital, Fudan University and included 1112 patients who had newly diagnosed or relapsed GD and were not receiving ATDs. Finally, 1000 patients were enrolled and they chose RAI treatment. Among them, some GD patients suffered from neutropenia, recurrence after a course of ATD, cardiac arrhythmias, hepatotoxicity, and thyrotoxic periodic paralysis. Other patients without complications chose RAI treatment because they were concerned about the potential side effects of ATDs or the rapid effect of RAI treatment. The diagnosis is based on the initial biochemical evaluation, diagnostic testing, and clinical presentation including goiter, ocular symptoms, rapid heartbeat, poor tolerance of heat, and weight loss. Baseline data for each participant were extracted from the Hospital's Health Information System and included sex, age, BMI (weight (kg)/height squared (m2)), blood cell count, thyroid function (free thyroxine (FT4), thyrotropin (TSH), TPO antibodies (TPOAb), TG antibodies (TGAb), and thyrotropin receptor antibodies (TRAb)), and RAIU (3 h RAIU and 24 h RAIU). A flowchart of the study is shown in Fig. 1. Patients were excluded from the study if they had any of the following: i) previous diagnosis of malignancy; ii) any infectious disease; iii) were pregnant or lactating; iv) any chronic autoimmune disease; v) severe cardiovascular or cerebrovascular events; and vi) other causes of neutropenia such as drug, hematological disorder, vitamin B12 deficiency, congenital causes, and so on. After exclusions, 1000 patients were enrolled in our study (Fig. 1) and were then grouped according to the presence or absence of neutropenia. Neutropenia was defined as a neutrophil count less than 2.0 × 109/L. The study protocol was approved by the Medical Ethics Committee of the Fifth People’s Hospital of Shanghai, Fudan University (NO. 2017-029).

Flowchart of study. GD, Graves' disease.

Publication 2023
Antibodies Ataxia Telangiectasia Blood Cell Count Cardiac Arrhythmia Cardiovascular System Communicable Diseases Diagnosis Disease, Chronic Ethics Committees, Clinical Eye Familial Periodic Paralysis Goiter Graves Disease Hematological Disease Leukopenia Long-Acting Thyroid Stimulator Malignant Neoplasms Neutrophil Patients Pharmaceutical Preparations Recurrence Thermotolerance Thyroid Gland Thyrotropin Thyroxine Vitamin B 12 Deficiency
KRIT1−/− and KRIT1+/+ mouse embryonic fibroblasts (MEFs) were obtained by Dr. Luca Goitre in the laboratory of Cell Biology, under the supervision of Prof. Saverio Francesco Retta, at the Department of Clinical and Biological Sciences of the University of Torino. Specifically, KRIT1−/− and KRIT1+/+ mouse embryonic fibroblast (MEF) isogenic cell lines were established from KRIT1−/− and KRIT1+/+ E8.5 mouse embryos, respectively, using the 3T3 protocol [45 (link)], and were previously described [17 (link),42 (link)]. The KRIT1 gene was inactivated by homologous recombination, using a vector obtained by Dr. Luca Goitre, deleting a 631 bp genomic region encompassing 77 nucleotides of the first exon, including the ATG codon, and 554 bp of the upstream 59 untranslated sequence, and replacing this region with a pMC1-Neo-Poly(A) cassette. KRIT1+/+ cells were derived from KRIT1−/− MEFs by lentiviral re-expression of KRIT1 in order to obtain KRIT1-null and KRIT1-expressing MEF cells with uniform genetic backgrounds to be used for comparative molecular and cellular biology studies [17 (link),42 (link)]. Specifically, KRIT1−/− MEF cells were infected with a lentiviral vector encoding KRIT1 (pCCLsin.PPT.PGK.KRIT1.Wpre, obtained by Dr. Luca Goitre) to restore KRIT1 expression. Cells were cultured in DMEM (Gibco) containing 10% v/v heat-inactivated fetal bovine serum (FBS; Gibco), 2 mM glutamine (Gibco), 10 U/mL penicillin (Invitrogen), and 10 µg/mL streptomycin (Invitrogen), at 37 °C and 5% CO2.
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Publication 2023
BP 554 Cell Lines Cells Cloning Vectors Codon Embryo Exons Fibroblasts Genes Genetic Background Genome Glutamine Goiter Homologous Recombination KRIT1 protein, human Mus Nucleotides Penicillins Poly A Streptomycin Supervision
The thyroid functional status and goiter size were measured periodically, usually at 1–2 months after surgery, then every 3–6 months. Failure of treatment was defined as a recurrence of hyperthyroidism at 12 months, requiring either long-term ATD therapy, a repeat dose of RAI, or thyroidectomy. Conversely, successful treatment was defined as a euthyroid or hypothyroid status with a normal-looking neck at 12 months. When the patients presented with hypothyroidism under thyroxine replacement, they received long-term follow-up at least every 3 months. Other complications were also recorded.
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Publication 2023
Goiter Hyperthyroidism Hypothyroidism Neck Operative Surgical Procedures Patients Recurrence Thyroidectomy Thyroid Gland Thyroxine
For our research involving human participants including the use of images, informed consent from all subjects and /or their legal guardians were obtained for both study participation and publication of identifying images in an online open-access publication The clinical research was also approved by the Institutional Review Board of our hospital (No 202101890B0) and was conducted in accordance with the Declaration of Helsinki. We performed a retrospective review of patients who underwent thyroidectomy using TOETVA at our endocrine surgical unit to treat different goiter sizes in GD between January 2019 and December 2020. The demographic and clinical data were collected. All patients were followed up for > 12 months. The goiter size was identified by palpation and classified into four grades: grade 0, no palpable goiter; grade 1, a palpable goiter not reaching the medial edge of the sternocleidomastoid muscle; grade 2, a palpable goiter reaching the sternocleidomastoid muscle but not exceeding the lateral edge; and grade 3, a palpable goiter exceeding the lateral edge of the sternocleidomastoid muscle5 (link).
The indications for choosing surgery were recorded. The exclusion criteria were any degree of Graves’ ophthalmopathy, because RAI may worsen ophthalmopathy; women planning a pregnancy or breastfeeding within 6 months of surgery; a toxic multinodular goiter or any nodules with suspected malignancy; and neck surgery or radiation before TOETVA. If a patient had no clear, absolute or relative, contraindication for surgery but expressed a preference for surgery, it was recorded as the patient’s preference.
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Publication 2023
Endocrine Surgical Procedures Ethics Committees, Research Eye Disorders Goiter Homo sapiens Legal Guardians Malignant Neoplasms Muscle Tissue Neck Operative Surgical Procedures Palpation Patients Pregnancy Radiotherapy Thyroid-Associated Ophthalmopathy Thyroidectomy Woman

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Publication 2023
Adult Alopecia Ancylostomatoidea Anemia Ascaris lumbricoides Ascorbic Acid Deficiency Awareness Blood Child Child Malnutrition Children's Health Conjunctiva Cornea COVID 19 Deficiency, Iron Dermatitis Diagnosis Diarrhea Edema Eggs Escherichia coli Ethyl Ether Exanthema Face Feces Filtration Food Formalin Gingival Hemorrhage Goiter Helminthiasis Helminths Hemorrhage Hypersensitivity Index, Body Mass Infection Interviewers Intestinal helminthiasis Intestines Iodine Laboratory Technicians Leg Malnutrition Mental Recall Microscopy Mucus Niacin Parasitic Diseases PER1 protein, human Pigmentation Porifera Protein Deficiency Respiratory Tract Infections Riboflavin Saline Solution Thiamine Thiamine Deficiency Tissue, Membrane Tongue Trichuris trichiuras Vitamin A Deficiency Vitamin D Deficiency Youth

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More about "Goiter"

Goiter is a condition characterized by an enlargement of the thyroid gland, often resulting from iodine deficiency or other underlying medical issues.
This swelling in the neck can lead to a variety of symptoms, such as breathing difficulties, changes in hormone production, and a visible lump.
Researchers can utilize advanced tools like PubCompare.ai's AI-driven platform to optimize their goiter studies, helping them locate the best research protocols from literature, preprints, and patents through intelligent comparisons.
This innovative solution can enhance the reproducibility and accuracy of goiter research, supporting advancements in the diagnosis, treatment, and management of this common thyroid disorder.
Goiter is also known by other names, including thyromegaly and struma.
It can be classified into different types, such as simple goiter, multinodular goiter, and toxic goiter, each with its own characteristics and underlying causes.
Factors like genetics, autoimmune disorders, and exposure to radiation can also contribute to the development of goiter.
In addition to PubCompare.ai, researchers may employ a variety of statistical software and tools to analyze data and findings related to goiter.
These include SAS version 9.4, SPSS version 25, SPSS version 20, Epi Info version 7, FBS, SPSS version 24, and SPSS version 21.
Specialized laboratory techniques, such as the use of HRP-conjugated rat anti-HA antibodies, may also be utilized in goiter research.
Accurate diagnosis and effective management of goiter are crucial, as the condition can lead to serious complications if left untreated.
Advancements in goiter research, facilitated by innovative tools like PubCompare.ai, can contribute to improved patient outcomes and a better understanding of this common thyroid disorder.