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Intraabdominal Infections

Intraabdominal Infections: A comprehensive overview of the most effective research protocols for managing these complex conditions.
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Most cited protocols related to «Intraabdominal Infections»

The TIDOS project is an observational cohort study of short and long term infectious disease outcomes following a deployment-related traumatic injury. TIDOS cohort eligibility criteria include the following: active duty personnel or DoD beneficiary, ≥ 18 years of age, wounded or injured during deployment requiring return via Level IV at Landstuhl Regional Medical Center (LRMC), Landstuhl, Germany to a participating DoD hospital in the U.S., and providing informed consent or surrogate consent through a legally authorized representative. Participating Level V clinical sites include the National Naval Medical Center (NNMC), Bethesda, MD, Brooke Army Medical Center (BAMC), San Antonio, TX, and Walter Reed Army Medical Center (WRAMC), Washington DC. Consenting patients are enrolled in the study prior to discharge from one of the participating Level V hospitals. Participants are contacted periodically at 1, 3, 6, 12, 18, 24 months and then yearly for 5 years after discharge. Follow-up methods include subject interviews, web-based questionnaires, and query of DoD and Department of Veterans Affairs electronic healthcare databases.
Patient trauma history, injury severity scoring, and surgical management is obtained through selected data elements retrieved from the DoD Joint Theater Trauma Registry (JTTR).5 (link) The JTTR was established by the Assistant Secretary of Defense for Health Affairs as a means to provide an effective performance improvement tool to assess combat casualty care epidemiology, treatment, and outcome. An infectious diseases (ID) module to augment the JTTR was developed to capture infection-specific data throughout levels of care at participating hospitals. This ID-specific information includes diagnoses, treatments, and outcomes of bloodstream infections (BSI), clinical sepsis, bone and joint infections, skin and soft tissue infections (SSTI), central nervous system infections (CNS), intra-thoracic/pulmonary infections, and intra-abdominal infection. The JTTR/ID module captures data on all active duty military trauma patients admitted to Level IV and selected Level V facilities. A comprehensive assessment of the overall population and the representativeness of the TIDOS cohort were performed by analyzing de-identified JTTR/ID module data from non-enrolled trauma patients admitted through Level IV during the period. The study is approved by the institutional review boards of the Uniformed Services University of the Health Sciences and the St. Louis Veterans Administration Medical Center (VAMC).
This report includes subjects admitted to Level IV during the first three months of the study (June 1 – August 31, 2009) along with subject experience through Level V hospitalization (for those admitted to participating Level V sites) and up to 6-months of follow-up post Level V discharge (for those consenting to follow-up).
Publication 2011
Bones Central Nervous System Infection Communicable Diseases Diagnosis Eligibility Determination Ethics Committees, Research Health Services, University Hospitalization Infection Injuries Intraabdominal Infections Joints Lung Military Personnel Operative Surgical Procedures Patient Discharge Patients Persistent Infection Sepsis Septicemia Skin Soft Tissue Infection Veterans Wounds and Injuries
To induce acute experimental colitis, mice were administered 1.5-3.0% (w/v) dextran sodium sulfate (DSS, molecular weight, 36-50 kDa; MP Biomedicals, UK) in their drinking water ad libitum for 7 days followed by 7 days normal water. Parthenolide (PTL) (10 mg/kg) suspended in saline was administered by intraperitoneal (i.p.) injection in PTL+DSS group mice from day 0 to day 14 until the end of experiments. Mice in DSS group underwent i.p. injection of normal saline as a negative control. To avoid abdominal infection caused by i.p. injection, the procedures were strictly performed under sterile conditions. In all colitis models, mice were checked daily for morbidity and body weight was recorded. Each mouse was scored daily for pathological features, including stool consistency, presence of blood stool, and body weight loss. Individual scores were combined to generate the Disease Activity Index (DAI) which was calculated daily for each mouse. The maximum score was 12 based on assigning a 0-4 scoring system for following parameters (Supplementary Table S1).
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Publication 2020
BLOOD Body Weight Colitis Dextran Sulfate Sodium Feces Human Body Intraabdominal Infections Mus Normal Saline parthenolide Saline Solution Sterility, Reproductive
The primary outcome measure is time to functional recovery (days), which will be daily assessed by the nurses and ward physicians, and cross-checked by the trial coordinators. Functional recovery is reached when all of the following criteria are met [14 (link)]:

Adequate pain control with oral analgesia only

Restoration of mobility to an independent level (or to preoperative level if previously impaired)

Ability to maintain sufficient caloric intake (minimum of 50% required calories)

Absence of intravenous fluid administration

No signs of active abdominal infection (In the case of suspected or known abdominal infection this item is met when the patient has no fever, and serum C-reactive protein concentration is decreasing and below 150 mg/L.)

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Publication 2018
Fever Intraabdominal Infections Management, Pain Nurses Patients Physicians Range of Motion, Articular Recovery of Function Serum Proteins
Blood cultures were collected and processed free of charge in healthcare facilities in the capital, Kinshasa, and the Bas-Congo province (referral hospital of Kisantu) and later extended to sentinel hospitals in the Oriental Province (University Hospital Kisangani with affiliated hospitals and health centers) and the Equateur Province (referral hospital of Bwamanda). Over the years, this network was extended with other partners, and blood cultures were also added to the diagnostic tools of the outbreak investigation teams of INRB in collaboration with the Ministry of Health. Indications of blood culture sampling were, outside the neonatal period, a body temperature of ≥38.0°C or ≤35.5°C (axillary) or history of fever during the last 48 hours and/or (1) signs of severity such as hypotension, confusion, or increased respiratory rate; (2) suspicion of severe localized infections (pneumonia, meningitis, complicated urinary tract infection, osteomyelitis and arthritis, severe skin and soft tissue infections, gynecological and abdominal infections/peritonitis); or (3) suspicion of other severe infection: sepsis, typhoid fever, and severe malaria. Basic demographic and clinical data were recorded. In adults, blood cultures consisted of 2 × 10 mL of blood sampled in aerobic BACT/ALERT bottles (bioMérieux, Marcy-L’Etoile, France); for children (defined as ≤14 years old), 1–4 mL was sampled in pediatric BACT/ALERT bottles. Grown blood cultures were worked up for identification according to conventional biochemical methods and serotyping (for antibiotic susceptibility testing, see below). For reasons of integration in clinical care and capacity building, blood cultures were preferentially worked up in the participating referral hospitals. However, when no competent laboratory services were available, samples were transported to INRB for workup. Isolates were stored for in-depth reference testing, and the results of the blood culture isolates and their resistance patterns were registered. Coagulase-negative Staphylococcus, Corynebacterium species, Micrococcus species, Cutibacterium species, and Lactobacillus species were considered as environmental or skin contaminants; the other bacteria were classified as pathogens. The term “suspected bloodstream infection (BSI) episode” was used to indicate all blood cultures in a single patient sampled within a 2-week period according to the indications mentioned above. A BSI episode was considered as culture confirmed when a pathogen was isolated in at least 1 of the bottles. Supplementary Document 1 provides a detailed overview of the workflow, criteria, and definitions used in the sampling, and the processing and reporting of the blood cultures.
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Publication 2019
Adult Antibiotics Arthritis Asian Persons Axilla Bacteria Bacteria, Aerobic Blood Blood Culture Body Temperature Child Coagulase Corynebacterium Diagnosis Fever Focal Infection Hospital Referral Infant, Newborn Infection Intraabdominal Infections Lactobacillus Malaria Meningitis Micrococcus Osteomyelitis Pathogenicity Patients Peritonitis Pneumonia Sepsis Septicemia Skin Soft Tissue Infection Staphylococcus Susceptibility, Disease Typhoid Fever Urinary Tract Infection
The NACSELD database comprises prospectively collected data following informed consent from patients with cirrhosis hospitalized in 18 hepatology referral centers across the USA and Canada. Patients with an infection or who subsequently develop nosocomial infections are included. The study has been approved by the respective Institutional Review Boards of the participating centers and uses a REDCap (Research Electronic Data Capture) tool that is located at Virginia Commonwealth University. REDCap is a secure, web-based application designed to support data capture for research studies, providing: 1) an intuitive interface for validated data entry; 2) audit trails for tracking data manipulation and export procedures; 3) automated export procedures for seamless data downloads to common statistical packages; and 4) procedures for importing data from external sources.
Cirrhosis is diagnosed with a combination of biochemical, radiological and endoscopic findings if liver biopsy confirmation is not available. Patients who had infections but did not require hospital admission were excluded, as were patients who did not have an infection during their admission. Other exclusion criteria include immuno-compromised patients with human immunodeficiency virus (HIV) infection, prior organ transplant, and disseminated malignancies.
Once informed consent is obtained, data collection begins with patient demographic, vital signs, baseline full blood count, biochemistry, and assessment of liver and renal function. Details of the infection include antibiotic treatment as well as documentation of a second infection when applicable. Data regarding intensive care unit admissions, organ failures, liver transplantation, and length of hospital stay are also collected. Patients who are discharged alive are contacted at 30 days post-enrolment to determine survival.
We define infections according to standard criteria(4 (link)): (a) spontaneous bacteremia: positive blood cultures without a source of infection; (b) SBP: ascitic fluid polymorphonuclear cells >250/μL; (c) lower respiratory tract infections: new pulmonary infiltrate in the presence of: (i) at least one respiratory symptom (cough, sputum production, dyspnea, pleuritic pain) with (ii) at least one finding on auscultation (rales or crepitation) or one sign of infection (core body temperature >38°C or less than 36 °C, shivering or leucocyte count >10,000/mm3 or <4,000/mm3) in the absence of antibiotics; (d) Clostridium difficile Infection: diarrhea with a positive C. difficile assay; (e) bacterial entero-colitis: diarrhea or dysentery with a positive stool culture for Salmonella, Shigella, Yersinia, Campylobacter, or pathogenic E. coli; (f) soft-tissue/skin Infection: fever with cellulitis; (g) urinary tract infection (UTI): urine white blood cell >15/high power field with either positive urine gram stain or culture; (h) intra-abdominal infections: diverticulitis, appendicitis, cholangitis etc; (i) other infections not covered above, and (j) fungal infections as a separate category. Nosocomial infections were those diagnosed after 48 hours of admission while second infections were those that were diagnosed after a separate first infection had been documented.
We used standard organ failure definitions as (i) hepatic encephalopathy >grade III or IV by West Haven Criteria (ii) shock: [mean arterial pressure (MAP) < 60 mm Hg or a reduction of 40 mmHg in systolic blood pressure from baseline] despite adequate fluid resuscitation and cardiac output, (iii) need for mechanical ventilation and (iv) need for dialysis or other forms of renal replacement therapy. These simple definitions are used to ensure generalizability.
Publication 2014
Antibiotics Appendicitis Ascitic Fluid Auscultation Bacteremia Bacteria Biological Assay Biopsy Blood Culture Body Temperature Campylobacter Cardiac Output Cellulitis Cholangitis Colitis Complete Blood Count Cough Dialysis Diarrhea Diverticulitis Dysentery Dyspnea Endoscopy Escherichia coli Ethics Committees, Research Feces Fever Gram's stain Hepatic Encephalopathy HIV Infections Infection Infection, Clostridium difficile Infections, Hospital Intraabdominal Infections Kidney Leukocyte Count Leukocytes Liver Liver Cirrhosis Liver Transplantations Lung Malignant Neoplasms Mechanical Ventilation Mycoses Neutrophil Organ Transplantation Pain Pathogenicity Patients Pleurisy Renal Replacement Therapy Respiratory Tract Infections Resuscitation Salmonella Secondary Infections Shigella Shock Signs, Vital Signs and Symptoms, Respiratory Skin Soft Tissue Infection Sputum Systolic Pressure TNFSF10 protein, human Urinary Tract Infection Urine X-Rays, Diagnostic Yersinia

Most recents protocols related to «Intraabdominal Infections»

Baseline clinical profiles were collected and reviewed, including sex, age, Montreal classification [13 (link)] and baseline treatment. The detailed baseline clinical characteristics of CD were evaluated at the time of diagnosis of intestinal fistula. The Crohn’s Disease Activity Index (CDAI) was used to evaluate the disease activity in brief [14 (link)]. The characteristics of the fistula were classified by type, location, and the existence of a complex fistula. The fistula was defined as complex fistula if there were multiple fistula tracts or the patient has history of abdominal abscess. History of abdominal infection or abcess were also collected.
Laboratory data related to CD were also collected, including blood routine, albumin, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Due to the non-availability of data, serum IL-6 and TNF-α level and other indicators were not collected and included in the analysis. Serum IFX concentration were also not included.
Imaging data (enhanced abdominal and pelvic CT, CT enterography, or MR enterography) at baseline were reappraised. Data were collected including the characteritics of fistula, and other signs of CD activity, including thickening or strengthening of the intestinal wall, existence of stricture, thickened mesenteric vessels and enlarged mesenteric lymph nodes.
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Publication 2023
Abdomen Abdominal Abscess Abscess Blood Vessel C Reactive Protein Crohn Disease Diagnosis Fistula Intestinal Fistula Intestines Intraabdominal Infections Mesentery Nodes, Lymph Patients Pelvis Sedimentation Rates, Erythrocyte Serum Serum Albumin Stenosis Tumor Necrosis Factor-alpha
Our primary outcome was the correlation of composite complications (CC) with MS. A composite of postoperative complications defining as the overall occurrence of any symptoms of the following five components during hospitalization: (1) cardiovascular and cerebrovascular events (CCE), (2) non-pulmonary postoperative infection (NPPI), (3) pulmonary complications (PC), (4) complications requiring surgical intervention (CRSI), and (5) postoperative acute kidney injury (AKI). CCE included myocardial infarction, heart failure, cardiac arrest, stroke, and pulmonary embolism. NPPI were differentiated according to the location or system, such as superficial wound infection, pancreatic fistula, surgical incision, abdominal infection, urinary infection, systemic infection. PC10 (link) included pulmonary infection, atelectasis, pneumothorax, hemothorax, pleural effusion and respiratory related hypoxemia. Postoperative AKI was defined as a categorical variable according to the Kidney Disease Improving Global Outcomes work group, as any increase in postoperative serum creatinine of 0.3 mg/dL or more (to convert to micromoles per liter, multiply by 88.4) or a 50% increase from preoperative baseline serum creatinine level. The Cockcroft–Gault equation was adopted for eGFR evaluation, depending on patients’ gender. Secondary outcome were correlations of components of CC with MS and prognosis of complications.
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Publication 2023
Atelectasis Cardiac Arrest Cardiovascular System Cerebrovascular Accident Creatinine EGFR protein, human Gender Heart Failure Hemothorax Hospitalization Infection Intraabdominal Infections Kidney Diseases Kidney Failure, Acute Lung Myocardial Infarction Operative Surgical Procedures Pancreatic Fistula Patients Pleural Effusion Pneumothorax Postoperative Complications Prognosis Pulmonary Embolism Respiratory Rate Sepsis Serum Surgical Wound Urinary Tract Infection Wound Infection
Patients in study were observed closely after P-STER or ESD treatment for complications, including perforation, bleeding, and abdominal infection. Corresponding treatment was given once complications were encountered. Patients were kept fasting for 2 days after the procedure, and a liquid diet was followed for an additional 1 day if no complications or postoperative abdominal pain occurred. Diet was gradually restored to normal from the fourth day. Patients would be discharged on the fifth day if there were no complications or postoperative abdominal pain observed, otherwise the hospital discharge would be delayed at the discretion of the endoscopists. Postoperative medications mainly included proton pump inhibitor (PPI) and antibiotics. PPI, including esomeprazole (20 mg, twice a day), rabeprazole (20 mg, once a day), and so on, was required for at least 2 weeks. In terms of antibiotics, levofloxacin, sulperazon, or other third-generation cephalosporin could be administrated. All the 24 patients with prepyloric SMTs involved in this study were arranged with endoscopic follow-up in the local hospital or our hospital in April 2022.
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Publication 2023
Abdomen Abdominal Pain Antibiotics, Antitubercular Cephalosporins Diet Endoscopy Esomeprazole Intraabdominal Infections Levofloxacin Pain, Postoperative Patient Discharge Patients Pharmaceutical Preparations Proton Pump Inhibitors Rabeprazole sulperazone
Invasive disease was defined by the isolation of GAS from a normally sterile site (blood, bone, pleural fluid, synovial fluid, peritoneal fluid, or cerebrospinal fluid (CSF)).
Probable invasive disease was defined as an unwell patient with GAS isolated from a non-sterile site (deep skin or retropharyngeal aspiration) who required one or more of the following: hospitalization for intravenous antibiotics, surgery, or admission to the intensive care unit (ICU).
Clinical syndromes of piGAS and iGAS disease were categorized as isolated bacteremia, pneumonia/empyema, skin and soft tissue infection (SSTI) with or without bacteremia, NF, STSS, septic arthritis, osteitis, bursitis, abdominal/peritoneal infection, meningitis, pharyngeal abscess with and without bacteremia, and endometritis (pregnancy or not pregnancy related).
Clinical syndromes are presented in Supplementary Information 1. In case of concurrent diagnosis in the same patient, the most severe diagnosis was retained.
IGAS infections were considered healthcare related if they occurred at least 48 h after the time of admission or if the patient underwent surgery within the 7 days preceding the onset of iGAS. IGAS or piGAS infections were considered associated to chickenpox if it occurred within a maximum time span of 7 days from the onset of the varicella infection. The pediatric population was limited to children between 0 and 16 years. An adult was defined as a patient at least 17 years old.
The 2010 case definition [15 ] based on two major criteria (hypotension and the involvement of at least two organs/systems) was applied for the diagnosis of STSS.
Publication 2023
Abscess Adult Antibiotics Arthritis, Infectious Bacteremia Blood Bones Bursitis Cerebrospinal Fluid Chickenpox Child Diagnosis Empyema, Pleural Endometritis Hospitalization Infection Intraabdominal Infections Meningitis Operative Surgical Procedures Osteitis Patients Peritoneal Fluid Peritoneum Pharynx Pleura Pregnancy Skin Soft Tissue Infection Sterility, Reproductive Syndrome Synovial Fluid Tetradecyl Sulfate, Sodium
The diagnosis of MAFLD was based on the presence of hepatic steatosis (>5%, detected by postoperative liver histopathology) in addition to one of the following 3 criteria: body mass index (BMI) ≥ 23 kg/m2, T2DM, or metabolic dysregulation.[14 (link)] The metabolic dysregulation was defined as the presence of 2 or more of the following abnormalities: high waist circumference, hypertension, abnormal levels of plasma triglycerides or cholesterol, prediabetes or insulin resistance and high level of plasma high-sensitivity C-reactive protein.[14 (link)] Lean-MALFD was defined as the patients with MAFLD and BMI < 23kg/m2. Hepatectomy was defined as complete resection of all microscopic and macroscopic tumors with negative histologic resection margin.[17 (link)] Cirrhosis and hepatic steatosis were determined directly by imaging or postoperative hepatic histopathology. Alcohol consumption was defined as male ≥ 30 g/day, female ≥ 20 g/day.[18 (link)] HBV infection was defined as the evidence of hepatitis B surface antigen-positive and/or HBV DNA-positive. HBV-HCC refers to HCC caused by HBV infection. The severity of complications was graded using Dindo–Clavien classification.[19 (link)] Major complications were defined as complications of Clavien classification ≥ III. Among major complications, complications for which surgical or radiologic intervention with antibiotics was needed, such as intraabdominal infection, pneumonia, and wound infection and sepsis were defined as infectious complications. Postoperative death was defined as death from a postoperative complication within 30 days after hepatectomy.
Publication 2023
Antibiotics Cholesterol Congenital Abnormality C Reactive Protein Diagnosis Fatty Liver Hepatectomy Hepatitis B Surface Antigens High Blood Pressures Index, Body Mass Infection Insulin Resistance Intraabdominal Infections Liver Liver Cirrhosis Males Microscopy Neoplasms Operative Surgical Procedures Patients Plasma Pneumonia Postoperative Complications Septicemia States, Prediabetic Surgical Margins Triglycerides Waist Circumference Woman Wound Infection

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More about "Intraabdominal Infections"

Intraabdominal infections, also known as intra-abdominal infections (IAIs), are a common and complex group of conditions affecting the abdomen and surrounding tissues.
These infections can range from mild, localized cases to severe, life-threatening conditions, and can be caused by a variety of bacteria, viruses, and fungi.
Effective management of IAIs requires a comprehensive understanding of the latest research protocols and best practices.
Clinicians and researchers can utilize powerful AI-driven tools, such as those provided by PubCompare.ai, to streamline their research process and identify the optimal approaches for managing these conditions.
PubCompare.ai's platform uses advanced natural language processing and machine learning algorithms to analyze data from the literature, preprints, and patents, providing valuable insights and data-driven analysis.
This can help researchers and clinicians quickly locate and compare the most relevant research protocols, as well as identify the latest trends and best practices in the field.
For example, researchers may use techniques like matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and the Vitek 2 system to rapidly identify the pathogens responsible for IAIs.
They may also utilize Luria-Bertani (LB) broth and Brucella Blood Agar to culture and isolate the causative microorganisms.
Additionally, statistical software like SPSS Statistics 24 can be employed to analyze the data and identify the most effective treatment approaches.
Surgical interventions, such as the use of Permacol, a biological mesh material, may also be considered in certain cases.
By leveraging the latest research and advanced analytical tools, clinicians and researchers can optimize their intraabdominal infection studies and improve patient outcomes.
PubCompare.ai's AI-driven platform can be a valuable resource in this endeavor, providing the insights and data-driven analysis needed to streamline the research process and identify the best approaches for managing these complex conditions.