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Intussusception

Intussusception is a medical condition in which a segment of the intestine folds into the segment immediately ahead of it, causing an intestinal obstruction.
This can lead to serious complications if not treated promptly.
Typical symptoms include sudden, severe abdominal pain, vomiting, and bloody stools.
Intussusception is most common in young children, but can occur at any age.
Prompt diagnosis and treatment are critical to prevent potentially life-threatening complications.
PubCompare.ai can help researchers optimize their Intussusception studies by enhancing reproducibility and accuracy, locating relevant protocols, and leveraging AI-driven comparisons to identify the best approaches.
Expereince the difference with PubCompare.ai's powerful tools today!

Most cited protocols related to «Intussusception»

1
Global Intussusception Incidence and Patterns
We grouped data according to seven geographic regions of the world: Africa, Asia, Central & South America, Eastern Mediterranean, Europe, North America, and Oceania. Because of heterogeneity in under 5 mortality rates (u5MR) in Asia, we grouped Asian countries into high u5MR and low/very low u5MR according to WHO classification [10] (link). We present data on incidence of intussusception among children<1 year of age. We averaged the annual rate when rates for multiple years were presented individually. Among countries reporting incidence of intussusception, we were also interested in determining incidence of intussusception by month during the first year of life. To determine a pooled estimate of intussusception incidence by month of age globally, we extrapolated the proportion of intussusception events by month of age from studies that either presented monthly incidence or number of cases to the remaining studies that only presented intussusception incidence among children <1 year of age. While only 5 studies reported intussusception incidence by month of age, an additional 17 studies presented data on number of cases by month of age.
For studies reporting data on seasonality, we pooled data by geographic region on number of intussusception cases by calendar month. We also present pooled data on diagnostic modality, treatment, and prevalence of death by geographic region. For diagnosis and treatment, we excluded cases where this information was missing or unspecified.
All analyses were done with Microsoft EXCEL (Microsoft Corp, 2007).
Jiang J., Jiang B., Parashar U., Nguyen T., Bines J, & Patel M.M. (2013). Childhood Intussusception: A Literature Review. PLoS ONE, 8(7), e68482.
Publication 2013
Asian Americans Child Diagnosis Genetic Heterogeneity Intussusception Only Child
2
Rotavirus Vaccination Benefit-Risk Analysis
All countries with a gross national income per capita of less than US$12 236 in the 2018 fiscal year were included in the model.16 An Excel-based static cohort model with a finely disaggregated age structure (weeks of age up to 5 years) was used to calculate potential benefits and risks of vaccination.17 In each country, the model was used to calculate numbers of doses administered, fully vaccinated infants, rotavirus gastroenteritis deaths, intussusception cases, and intussusception deaths expected to occur among all infants born in the year 2015 from birth to age 5.0 years. Estimated benefits (rotavirus gastroenteritis deaths averted) and risks (excess intussusception cases and deaths) were calculated by comparing each schedule scenario to a scenario with no rotavirus vaccination. The incremental benefits and risks of moving from age-restricted schedules to age-unrestricted schedules were also calculated. The primary outcome measure was the benefit–risk ratio of rotavirus vaccination (number of rotavirus gastroenteritis deaths prevented per excess intussusception death). Other indicators were the percent reduction in rotavirus gastroenteritis deaths, percent increase in intussusception deaths, number of fully vaccinated infants per excess intussusception case, and number of rotavirus gastroenteritis deaths prevented per dose administered.
Clark A., Tate J., Parashar U., Jit M., Hasso-Agopsowicz M., Henschke N., Lopman B., Van Zandvoort K., Pecenka C., Fine P, & Sanderson C. (2019). Mortality reduction benefits and intussusception risks of rotavirus vaccination in 135 low-income and middle-income countries: a modelling analysis of current and alternative schedules. The Lancet. Global Health, 7, e1541-e1552.
Publication 2019
Birth Childbirth Gastroenteritis Head Infant Intussusception Rotavirus Vaccination
3
Dynamic MR Proctography: Anorectal Imaging
Using a previously described technique, the anal sphincters were imaged by a disposable endorectal colon coil (MRInnervu®, Medrad, Inc., Indianola, PA, USA) prior to dynamic MR proctography. (3 (link), 25 (link)) After removing the endoanal coil, 120 cc of ultrasound gel was instilled into the rectum and a four-element phased-array coil placed around the pelvis. Dynamic MR proctography was performed by an interactive single-shot, fast spin-echo (SSFSE) imaging technique. (3 (link), 25 (link), 26 (link)) Images were acquired in the supine position with a field of view of 24 to 32 cm, slice thickness of 5 mm, TR (repetition time) of 1400 to 2000 ms, TE (echo time) of 90 ms, and a matrix size of 256 × 160 (NEX 0.5). An oblique sagittal plane bisecting the anorectum was defined by selecting three points from axial images during real-time imaging. Images were then acquired every 1.4 to 2 seconds during rest, squeeze and defecation. Using real-time image reconstruction, we monitored the exam, ensured performance of desired maneuvers, and instructed or encouraged patients.
A single radiologist, who pioneered anorectal MRI at this institution, has interpreted several hundred studies and was blinded to clinical history, obstetric events, physical examination and the results of other imaging studies analyzed all examinations. Internal anal sphincter abnormalities from endoanal MR were characterized as normal, mild focal thinning, marked focal thinning, defect, or atrophy. Internal sphincter atrophy was identified by diffuse thinning of this sphincter (i.e., measured diameter ≤ 1 mm). For the external sphincter, abnormalities were characterized as tears (i.e., complete disruption of the sphincter), scars (i.e., focal heterogeneous signal in the anal sphincter without complete disruption), or atrophy (i.e., diffuse reduction in muscle bulk on serial images below the level of the puborectalis, such that the muscle was identifiable with difficulty.). The appearance of the puborectalis muscle was characterized by MRI as symmetric and normal, unilateral atrophy, or bilateral atrophy. (3 (link), 27 (link)) A focal heterogeneous signal in the anal sphincter without a complete disruption was characterized as a scar. For the external sphincter, atrophy was defined by a
For dynamic images, we evaluated the absolute value of, and changes in, the anorectal angle and perineal descent of the anorectal junction at rest and during defecation using established methods. (3 (link), 25 (link)) Perineal descent was measured by the difference in the perpendicular distance of the anorectal junction from the pubococcygeal line at rest and during defecation. Anatomic defects and abnormalities present on dynamic images such as rectal prolapse, intussusception, enteroceles or peritoneoceles, and cystoceles were noted.
Bharucha A.E., Fletcher J.G., Melton LJ I.I.I, & Zinsmeister A.R. (2012). OBSTETRIC TRAUMA, PELVIC FLOOR INJURY AND FECAL INCONTINENCE: A POPULATION-BASED CASE-CONTROL STUDY. The American journal of gastroenterology, 107(6), 902-911.
Publication 2012
Atrophy Cicatrix Colon Congenital Abnormality Cystocele Defecation Defecography Dietary Fiber ECHO protocol Enterocele Genetic Heterogeneity Internal Anal Sphincter Intussusception Muscle Tissue Neoplasm Metastasis Patients Pelvis Perineum Physical Examination Radiologist Rectal Prolapse Rectum Sphincters, Anal Tears Ultrasonography
4
Modeling Rotavirus Vaccine Schedules
Deterministic central estimates (ie, best estimates for each input parameter) and probabilistic 95% uncertainty intervals (UIs) were calculated for 11 age-restricted schedules and 18 age-unrestricted schedules. All input parameters and their distributions are shown in the appendix (p 16). Central estimates were also calculated for six what-if scenarios: RRs of intussusception varying with under-5 mortality (figure, appendix p 12); double the RR of intussusception for the first dose when given after 15 weeks of age; vaccine efficacy and waning equivalent to low-mortality settings; less rapid waning efficacy (based on a power function described in detail elsewhere);7 (link) less rapid waning efficacy for all primary doses administered as part of a neonatal schedule (appendix p 14); and pessimistic access to hospital for intussusception cases (based on the proportion of children with 2 h access to a public hospital).28 (link)Results for each schedule option reflect the totals expected in all 135 LMICs if all countries used the same schedule. However, to illustrate the maximum potential direct effect of the current live oral vaccines, separate totals for the model outcomes were calculated to show results if each country used the schedule predicted to have the highest reduction in rotavirus gastroenteritis deaths.
Clark A., Tate J., Parashar U., Jit M., Hasso-Agopsowicz M., Henschke N., Lopman B., Van Zandvoort K., Pecenka C., Fine P, & Sanderson C. (2019). Mortality reduction benefits and intussusception risks of rotavirus vaccination in 135 low-income and middle-income countries: a modelling analysis of current and alternative schedules. The Lancet. Global Health, 7, e1541-e1552.
Publication 2019
Child Gastroenteritis Infant, Newborn Intussusception Pessimism Rotavirus Vaccines, Attenuated
5
Intussusception Incidence, Age, and CFR
We compiled a database containing information on intussusception incidence rates, age distributions and CFRs in children aged <5 years. For all studies, we extracted the country, subnational location, study design, case definition, period of data collection and age range. To obtain more granular age distributions, we emailed an invitation letter to all authors who were listed in the Jiang et al. review (2002–12)3 (link) and all authors identified in the new systematic review (2012–18). We invited each author to share a spreadsheet table with counts of intussusception hospital admissions by week of age up to 5.0 years. If the authors did not respond, then we extracted the age distributions published in the research article. We also extracted the published incidence rate and the number of intussusception cases and deaths.
A country dataset was defined as any dataset with hospitalized patients before the introduction of rotavirus vaccine, taken from a single study in a single country and reporting on a single outcome, e.g. age distribution, incidence rate and CFR. If a study included multiple years and multiple sites, then all pre-vaccination years and subnational sites were aggregated and included in the same country dataset. The main outcome/presentation was hospital admissions, but we also included emergency room visits if admissions were not reported in the same study.
Clark A.D., Hasso-Agopsowicz M., Kraus M.W., Stockdale L.K., Sanderson C.F., Parashar U.D, & Tate J.E. (2019). Update on the global epidemiology of intussusception: a systematic review of incidence rates, age distributions and case-fatality ratios among children aged <5 years, before the introduction of rotavirus vaccination. International Journal of Epidemiology, 48(4), 1316-1326.
Publication 2019
Child Intussusception Patients Rotavirus Vaccines Vaccination

Most recents protocols related to «Intussusception»

1
Adhesion-Induced Intestinal Obstruction Treatment
The study included 229 children who underwent emergency surgical treatment for AIO and who had previously (primarily) been operated on: acute appendicitis -137 (59.8%), introsusception -36 (15.7%), blunt abdominal trauma -34 (14.8%), necrotizing enterocolitis -15 (6.5%), liver echinococcosis -5 (2.2%), and Payer’s disease -2 (0.9%). Boys to girls ratio made 1.3:1. The average age of the patients was 9.8±1.7 years old. Group 1 included 116 children, Group 2–113. The study was conducted in the clinical facilities of Stavropol Regional Children’s Clinical Hospital, Grozny Children’s Clinical Hospital No 2, and Makhachkkala Republican Children’s Clinical Hospital.
On children with the signs of AIO, treatment was started with conservative measures in the form of nasogastric intubation, infusion therapy, cleansing, and saline enema. No effect of the conducted treatment was the indication for surgery. The surgical treatment consisted of the elimination of cause of the mechanical intestinal obstruction (dissection of adhesions, untwisting, and laying the sentinel loops in the physiological position, and so on). Children who underwent colostomy were not included in this study.
The author’s method was used for all Group 1 children within the first 4 days of the post-operative period. Then, for up to 5–6 days (11 patients) of the post-operative period, the procedure was continued for the patients that were somewhat difficult to activate due to their young age, degree of severity of the post-operative condition, patient, pronounced predisposition to adhesions.
In the post-operative period, the abdominal brain exposure to the variable magnetic field was used for Group 2 to arrest the intestinal distention. The device “Magniter” was applied to the anterior abdominal wall for 20 min daily during the first 4 days of the post-operative period. From 5 to 15 post-operative days, the control group of patients received electrophoresis with hyaluronidase 64 IU.
During the treatment efficacy assessment, the following criteria were considered: Subjective data (intensity of pain and asthenic syndrome and quality of life); objective data, including the dynamics of symptoms (pain, edema, and hyperemia) and period of the patients staying at the hospital.
The adhesive process in the abdomen was determined using the Androsov, Blonov, and Knokh position specimens. These specimens are based on the creation of the thrust vector during mechanical tractions causing the adhesion tensioning between points of its attachment to various sites of the abdomen. Pain appearance or intensification is clinically determined.
The ultrasound examination of the abdomen was performed on GE Pro series LOGIQ 500 and SonoAce PICO using the curvilinear transabdominal multifrequency transducers within the range from 3.5 to 7.5 MHz. The echostructure of the abdomen, mobility of parietal and visceral peritoneum, “return” symptoms and small bowel dyskinesia in the area of its fixation by adhesives were examined.
Gudiev C., Minaev S, & Vasiliev V. (2023). Method of prevention of post-operative peritoneal adhesions. Northern Clinics of Istanbul, 10(1), 33-39.
Publication 2023
Abdomen Abdominal Cavity Appendicitis Boys Brain Cardiac Arrest Child Cloning Vectors Colostomy Debility Dissection Dyskinesias Echinococcosis, Hepatic Edema Electrophoresis Emergencies Enema Hyaluronidase Hyperemia Injury, Abdominal Intestinal Obstruction Intestines Intestines, Small Intubation, Nasogastric Intussusception Magnetic Fields Medical Devices Necrotizing Enterocolitis Operative Surgical Procedures Pain Patients physiology Range of Motion, Articular Saline Solution Severity, Pain Susceptibility, Disease Syndrome Traction Transducers Treatment, Emergency Ultrasonography Visceral Peritoneum Wall, Abdominal Woman
2
Defecography for Rectal Structural Diseases
Patients who were suspected to suffer from rectal structural diseases such as rectocele or intussusception underwent defecography. The presence of poor opening of the anorectal angle, poor relaxation of the anal canal, or poor expulsive effort generated which is related to retention of more than 50% contrast was defined as abnormal (14 (link)).
Jiang Y., Wang Y., Wang M., Lin L, & Tang Y. (2023). Clinical significance and related factors of rectal hyposensitivity in patients with functional defecation disorder. Frontiers in Medicine, 10, 1119617.
Publication 2023
Anal Canal Defecography Intussusception Patients Rectal Diseases Rectocele Retention (Psychology)
3
Chronic Constipation Patient Recruitment
In total, 53 patients with CC were consecutively recruited from the Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, between September 2017 and September 2019. The patients were diagnosed based on the Rome III criteria for CC.28 (link) In all, 31 healthy participants were also recruited from the physical examination center of the same institution and assigned to a healthy control (HC) group. The frequency of spontaneous bowel movements of healthy participants should be more than 3 times per week. Individuals who were pregnant, those who had a history of abuse, and those were on drugs that could affect defecation (e.g. antidepressants, spasmolytics, and opioids, but not hypnotics) were excluded. Subjects with a history of antibiotic treatment or intentional probiotic consumption 1 month prior to starting this study were also excluded. The other exclusion criteria were the presence of structural diseases (e.g. tumor, rectocele, and intussusception) based on colonoscopic or barium enema findings); chronic conditions; and previous gastrointestinal surgery. The reporting of this study conforms to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement.29 (link)
Yu T., Ding Y., Qian D., Lin L, & Tang Y. (2023). Characteristics of fecal microbiota in different constipation subtypes and association with colon physiology, lifestyle factors, and psychological status. Therapeutic Advances in Gastroenterology, 16, 17562848231154101.
Publication 2023
Antibiotics Antidepressive Agents Antispasmodics Barium Enema Chronic Condition Colonoscopy Defecation Drug Abuse Gastrointestinal Surgical Procedure Healthy Volunteers Hypnotics Intussusception Neoplasms Opioids Patients Pharmaceutical Preparations Physical Examination Probiotics Rectocele
4
HAEC Admission Criteria and Outcomes

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Publication 2023
Abdomen Abdominal Pain Aminoglycosides Antibiotics, Antitubercular Appendicitis Cephalosporins Colitis Diagnosis Diarrhea Enteritis Fluoroquinolones GPI protein, human Inpatient Intestinal Perforation Intussusception Macrolides Metronidazole Nausea Patients Penicillins Septicemia Tetracyclines
5
Ultrasound Evaluation of Pediatric Appendicitis
All children presenting to the Emergency Department (ED) with a principal complaint of abdominal pain were retrospectively considered for inclusion between January 2017 and May 2019. Consecutive USS reports including the terms “appendix” or “appendicitis” were screened. To verify they were performed for suspected appendicitis, correlation with the electronic hospital records and the clinical indications were reviewed. USS were excluded if primarily investigating chronic non-specific abdominal pain, intussusception, or a known appendiceal mass. Children with previous appendicectomy were excluded.
USS were grouped into four operative outcomes: No Appendicectomy (NoA), Negative appendicectomy (NegA), SA and CA. NoA was confirmed via clinical follow-up for 12 months, NegA was confirmed on histology in the absence of acute inflammation. SA was defined as non-perforated, incorporating inflammatory changes or gangrenous appendices. CA was intraoperatively defined as macroscopic perforation, intraperitoneal appendicolith or four-quadrant pus [1 (link)]. CA also included clinically or radiologically detected appendiceal abscess or mass. If a child had undergone two USS before intervention, the former was classified as NoA, with the latter in the appropriate operative category; assuming this aided the decision for surgery. When an intraoperative result suggested SA, and histology demonstrated CA; intraoperative results were utilised. This reflects clinical management and acknowledges potential iatrogenic perforation during appendicectomy. Clinical follow-up was for 12 months.
Tong L., Nataraja R.M., VanHaltren K., Sulaksana T.H., Vinycomb T.I, & Pacilli M. (2023). The utility of sonographic signs to diagnose simple and complicated appendicitis in children. Pediatric Surgery International, 39(1), 114.
Publication 2023
Abdominal Pain Abscess Appendectomy Appendicitis Child Gangrene Inflammation Intussusception Operative Surgical Procedures

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More about "Intussusception"

Intussusception is a medical condition where a portion of the intestine folds into the segment immediately ahead of it, causing an intestinal obstruction.
This can lead to serious complications if not treated promptly.
Common symptoms include sudden, severe abdominal pain, vomiting, and bloody stools.
Intussusception is most prevalent in young children, but can occur at any age.
Prompt diagnosis and treatment are critical to prevent potentially life-threatening complications.
Researchers can leverage PubCompare.ai's powerful tools to optimize their Intussusception studies.
The platform can enhance reproducibility and accuracy, helping researchers locate relevant protocols from literature, preprints, and patents.
PubCompare.ai's AI-driven comparisons can also identify the best approaches and products for their studies, improving research outcomes.
When studying Intussusception, researchers may utilize a variety of software and tools, such as SAS version 9.4, Omnipaque, SAS statistical software, AxioVision 4.8, Stata software, OpmiVario, Stata version 14, Cell^D software, SPSS version 22.0, and Enzyme-linked immunosorbent assay (ELISA) kits.
These tools can provide valuable data analysis, visualization, and experimental capabilities to support Intussusception research.
Experieence the difference with PubCompare.ai's advanced features and unlock new possibilities in your Intussusception research today.