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Occupational Diseases

Occupational Diseases are health conditions caused by exposures or hazards encountered in the workplace.
These can include respiratory illnesses, musculoskeletal disorders, neurological problems, and more.
Identifying effective protocols for studying and managing occupational diseases is crucial for worker health and safety.
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This can help streamline the research prcess and acheive more robust, reproducible results.

Most cited protocols related to «Occupational Diseases»

At a preliminary meeting of the ‘IMPALA’ International Partnership (www.lstmed.ac.uk/impala), representing expertise in asthma, COPD, air quality, smoking and occupational lung disease, we identified existing validated tools, including the World Health Organization household energy use survey and questions on nutrition developed by experts from the Global Asthma Network. After consultation with the original authors and developers, we held structured discussions with in-country colleagues to identify areas in which existing questionnaires were inadequate, improperly focussed or unsuitable for direct deployment in sub Saharan Africa. The agreed targets were context-appropriate tools to assess lung disease symptoms, smoking, nutrition, household energy use, history of tuberculosis, and wider lifetime exposures to risk factors for lung disease, including occupation (see Table 1).
New questionnaires were collaboratively created on a shared online platform (Kobo toolbox). Where possible we adapted existing tools: others were developed de novo. Insights from external advisors with specific expertise (e.g., dietary contributors to lung health) and situational knowledge relating to the Malawian context were sought and used to refine questionnaire scope and design. A single co-ordinating team ensured coherence and completeness across the tools with collaborative meetings, both remotely and in person, held throughout the process to share insights and progress updates. Prior to any further processes, the questionnaires’ content validity (the extent to which the tool measures the complete spectrum of the construct) and criterion validity (in comparison to a ‘gold standard’ or proxy) were considered by an expert panel with broad previous field research experience. The questionnaires were translated into Chichewa by two Malawian translators, with two independent parallel translations in most cases. Subsequent discussions were held between translators and a research coordinator to resolve areas of difficulty or discord.
Original and translated versions were then taken forward for consultation in a series of meetings with pre-established lay focus groups, locally known as community advisory groups [11 (link)]. Separate meetings, each of approximately nine people from urban Blantyre and from rural Chikwawa, gave feedback on the comprehensibility and contextual relevance of the questionnaires, within a pre-agreed consultation framework. Meetings were conducted in a combination of English and Chichewa, with fieldworkers and community advisory group coordinators in key positions as linguistic intermediaries. Lay members were organised into subgroups of three, each with a bilingual member of staff with prior understanding of the questionnaire content in a coordinating position. This allowed for guided debate where all voices could be heard, before consensus opinion was sought amongst the wider group. In terms of participant selection, purposive sampling was used to allow fuller representation by age, gender and occupation.
The consultation meetings were part of ongoing work within the science communication group, with specific Research Ethics Committee approval granted for the testing of the questionnaires in Malawi (College of Medicine Research Ethics Committee P.02/18/2349) and planned for other sites.
Questionnaires with more original content and those with significant anticipated context-sensitive elements were fully considered by focus groups from both urban and rural areas. Others, based on established sources were only put to one group, although members considered how the questions might be understood and applicable more broadly (detailed in Table 1).
The resulting questionnaires, including flow and skip-logic were circulated, first to key researchers in the team, then to the wider expert group for feedback. Suggested changes were discussed and agreed on amongst coordinators before incorporation to the final questionnaire set. Partners responsible for each individual tool also nominated key questions to be taken forward to form a composite ‘screening questionnaire’. The new questionnaires are being used by members of the wider collaboration in pilot projects, initially in Malawi and subsequently, after iterative adaptation processes, in other sites across sub Saharan Africa.
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Publication 2018
Acclimatization ARID1A protein, human Asthma Chronic Obstructive Airway Disease Diet Ethics Committees, Research Gender Gold Hearing Households Lung Lung Diseases Occupational Diseases Pharmaceutical Preparations Tuberculosis
The diagnosis of MM was made by means of thoracoscopy or video-assisted thoracoscopic surgery (VATS) in patients with pleural MM and by means of laparoscopy or laparotomy in peritoneal MM. The diagnosis was confirmed histopathologically by an experienced pathologist.2 (link)
The diagnosis of “no asbestos related disease” in the control group was confirmed by the experts of the Board for Recognition of Occupational Asbestos Diseases at the Clinical Institute of Occupational Medicine, which consisted of an occupational physician, pulmonologist and radiologist, as previously described. 16 (link)
A personal interview with each of the subjects was conducted to get the data about smoking using a standardized questionnaire. 29 (link) To determine asbestos exposure, a semiquantative method was used. For all the controls, data on cumulative asbestos exposure in fibres/cm3-years were available from the previous study. 29 (link) Data on cumulative asbestos exposure were also available for 27 MM patients. Based on these data, we divided the subjects into three groups: low (< 11 fibres/cm3-years), medium (11–20 fibres/cm3-years) and high (> 20 fibres/cm3-years) asbestos exposure. For the rest of the patients with MM, a thorough work history was obtained and where enough information was available, their exposures were compared with those from the group of patients with known cumulative asbestos exposure and were correspondingly divided into three groups with presumed low, medium and high asbestos exposures. 2 (link) Thus, 37 MM patients were assigned to one of these three groups, but for 95 MM patients epidemiological data were not sufficient to allow the assignment of patients to one of the groups; consequently, they were only categorized as exposed or non-exposed. The influence of asbestos exposure on MM risk was determined in the subgroup of patients where the asbestos exposure was known or could be assessed.
DNA of the MM patients and some controls without asbestos related diseases was available from our previous studies2 (link),30 (link), DNA of the rest of the controls was isolated from peripheral venous blood samples using FlexiGene DNA kit (Qiagen, Hilden, Germany).
Real-time polymerase chain reaction (PCR) based TaqMan assays were used for the analysis of NQO1 rs1800566, CAT rs1001179, SOD2 rs4880 and hOGG1 rs1052133 polymorphisms as recommended by the manufacturer (Thermo Fisher Scientific, SNP genotyping assay C_2091255_30, C_11468118_10, C_8709053_10 and C_3095552_1_, respectively). Genotyping was performed blinded regarding the study endpoints and repeated in 20% of samples to check for genotyping accuracy and all the genotypes were concordant. Amplification was not successful in 11 subjects for NQO1, in 2 for CAT, in 6 for SOD2 and in 7 subjects for hOGG1 polymorphism.
Publication 2018
Asbestos Biological Assay BLOOD Diagnosis Fibrosis Genetic Polymorphism Genotype GIT2 protein, human Laparoscopy Laparotomy NAD(P)H dehydrogenase (quinone) 1, human Occupational Diseases Pathologists Patients Peritoneum Physicians Pleura Pulmonologists Radiologist Real-Time Polymerase Chain Reaction SOD2 protein, human Thoracic Surgery, Video-Assisted Thoracoscopy Veins
Patients aged ≥18 years will be eligible for the trial if they have a physician-diagnosed fibrosing ILD, such as connective tissue disease (CTD)-associated ILD, chronic fibrosing hypersensitivity pneumonitis (HP), idiopathic non-specific interstitial pneumonia (iNSIP), unclassifiable idiopathic interstitial pneumonia (IIP), environmental/occupational lung disease or sarcoidosis, present with features of diffuse fibrosing lung disease of >10% extent on HRCT and meet the protocol criteria for progression within 24 months of screening, as assessed by the investigator. The criteria for evidence of progression are worsening lung function (clinically significant, ≥10% relative decline in forced vital capacity (FVC)) or worsening lung function (≥5–<10% relative decline in FVC) together with worsening respiratory symptoms and/or evidence of increasing fibrosis on chest imaging, despite treatment with unapproved medications used in clinical practice to treat ILD. A full list of the criteria for progression is provided in online  supplementary table S1.
At screening, the most recent HRCT image (taken within the previous 12 months) will be evaluated by central review according to the protocol to ensure that relevant lung fibrosis is present. In addition, the HRCT pattern will be determined for randomisation stratification. This review will be performed by two independent specialists in thoracic radiology with extensive expertise in the interpretation of HRCT of the chest. The reviewers will be blinded to patients’ demographic and clinical data.
In addition, eligible patients will have a FVC>45% of predicted value and a diffusing capacity of the lungs for carbon monoxide (DLCO) of >30% and <80% of predicted at randomisation.
As nintedanib is already approved for patients with IPF, patients will be excluded if they meet diagnostic criteria for IPF according to the ATS/European Respiratory Society (ERS)/Japanese Respiratory Society/Latin American Thoracic Association 2011 guidelines.13 (link) Patients with contraindications to nintedanib, as labelled, will also be excluded. Other exclusion criteria include treatment at baseline with any of the following drugs: azathioprine, cyclosporine, tacrolimus, rituximab, cyclophosphamide, mycophenolate mofetil or oral corticosteroids (>20 mg/day). Patients who require use of these medications to control an underlying disease such as CTD will not be considered for participation in the study. In case of worsening of PF-ILD and/or worsening of the underlying CTD during the treatment period, the use of any of these drugs will be allowed after 6 months of study treatment, if judged necessary by the investigator.
A full list of inclusion and exclusion criteria is given in online  supplementary table S1.
Publication 2017
Adrenal Cortex Hormones Azathioprine Chest Connective Tissue Diseases Cyclophosphamide Cyclosporine Diagnosis Disease Progression Europeans Extrinsic Allergic Alveolitis Fibrosis Forced Vital Capacity Idiopathic Interstitial Pneumonias Japanese Americans Lung Lung Diseases Monoxide, Carbon Mycophenolate Mofetil nintedanib Occupational Diseases Patients Pharmaceutical Preparations Pharmacotherapy Physicians Pulmonary Fibrosis Radiography, Thoracic Respiratory Physiology Respiratory Rate Rituximab Sarcoidosis Signs and Symptoms, Respiratory Specialists Tacrolimus
We evaluated the number of abstracts needed to read to identify one potentially pertinent article in the context of three different pathologies not generally thought to be work related: namely, ‘pancreatitis’, ‘atrial fibrillation’ and ‘meningioma’. For each pathology, we retrieved all the abstracts evoked by each of the two candidate search strategies. The same team of readers (ie, GM, MF and SM) assessed the pertinence of each abstract using the rating criteria described above. We then calculated the NNR values for each string.8 (link) We also calculated NNR values for two other proposed search strategies: (1) the string developed by Schaafsma et al for use by physicians looking for literature regarding diseases that have attracted more widespread study of possible occupational aetiology, that is (occupational risk OR occupational disease) AND name(s)-of-the-disease4 (link); (2) a string developed by the Cochrane Occupational Health Field for locating occupational health studies referring to work, that is (occupat* OR worker*) AND name(s)-of-the-disease.3 (link) Finally, we explored the effects of combining our first (more specific) string with the two (narrow/broad) aetiology search filters provided by PubMed for clinical queries regarding specific clinical study categories.9 10 (link)
Publication 2010
Atrial Fibrillation Meningioma N-(1-oxyl-2,2,5,5-tetramethyl-3-pyrrolidinyl)maleimide Occupational Diseases Pancreatitis Physicians Workers
An interview questionnaire was designed to collect the following data:
a) Socio-demographic characteristics such as gender, age, education, and occupation.
b) Knowledge about the disease, its nature, mode of transmission, symptoms and signs, incubation period, period of communicability, and preventive measures. This knowledge was assessed by 17 factual statements that participants responded to with "yes" or "no." A scoring system was applied to assess the level of knowledge of each subject: 1 point was given for each correct answer, and 0 point was given for each incorrect answer. Participants were grouped into three categories according to their level of knowledge: low (<10 points), average (10-12 points), and high (13 or more points).
c) Attitudes toward and perceptions of the disease, its severity, governmental efforts to combat it, and disease outcomes were assessed by six attitudinal statements that participants responded to with "strongly agree," "agree," "neutral," "disagree," or "strongly disagree." A scoring system was applied using the Likert 5-point scale; 5 points were assigned to "strongly agree," and 1 point was assigned to "strongly disagree." Negative attitude statements were scored from 1 (for those who strongly agreed) to 5 (for those who strongly disagreed). Thus, the total attitude score ranged from 6 to 30 points. For each statement, the participant was considered extremely concerned if he/she agreed or strongly agreed. Subjects were grouped into three categories according to their level of concern: extremely concerned (if agreement was evident for 5-6 statements), quite concerned (if agreement was evident for 3-4 statements), and little concerned (if agreement was evident for 2 or fewer statements).
d) Each participant was asked to report the precautionary measures that s/he has been using during the epidemic to prevent infection. Participants' responses were assessed in accordance with the six precautionary measures recommended by the U.S. Center for Disease Control (CDC). A scoring system was applied in which each participant was given 1 point for each precautionary measure taken. Thus, the total precaution score ranged from 0 to 6 points. A high level of precaution was considered to be 5-6 points, a moderate level was 3-4 points, and a poor level was 2 points or less.
Research coordinators and research assistants at the King Abdullah International Medical Research Center (KAIMRC) were trained to conduct the interviews. Each day, one of the co-authors assessed the accuracy and completeness of the data collection forms and the standardization of the procedures.
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Publication 2010
Epidemics Infection Occupational Diseases Perceptual Disorders Sex Characteristics Transmission, Communicable Disease

Most recents protocols related to «Occupational Diseases»

This retrospective study was conducted at the Occupational Diseases Training Clinic of Ankara Atatürk Sanatorium Training and Research Hospital, an essential tertiary referral center for pneumoconiosis in Turkey. The ethics committee approved the study (2012-KAEK-15/2479). The study included all patients with pneumoconiosis admitted to the hospital between January 1, 2014, and December 31, 2021. An occupational history of inorganic dust exposure, radiological findings consistent with pneumoconiosis, and exclusion of other diagnoses established the diagnosis. All available examinations obtained while diagnosing pneumoconiosis during the study period were considered for analysis.
Experienced pulmonary and occupational medicine specialists took the medical histories and performed the physical examinations of all patients. Medical history comprises information on the present illness, past medical and surgical history, tobacco use history, family history, personal or social history, and comprehensive occupational history. The detailed occupational history documented the patients’ present and past employment history and identified types of dust exposures at their workplaces. The occupational group was referred to as the job presumed to be the cause of pneumoconiosis by the occupational physicians of the clinic. We used the recorded smoking history to calculate tobacco pack years by multiplying the average number of cigarette packs per day by the total number of smoking years.
Spirometry was performed using the Zan 100 flow-sensitive spirometry device (ZAN Messgerate GmbH, Oberthulba, Germany). The spirometer was calibrated daily, with measurements of temperature and humidity used for calibration. The spirometry results were analyzed based on the acceptability and reproducibility criteria presented in the ATS/European Respiratory Society statement updating the standardization of spirometry. The patients’ spirometry measurements were evaluated based on the percentage of the reference values.
Chest X-rays (CXRs) were taken with a digital X-Ray system. CXRs were evaluated by two readers separately and independently according to the International Labour Organization’s (ILO) International Classification of Radiographs of Pneumoconioses, and the results were obtained in consensus. Small opacities are described by profusion, shape (rounded or irregular), and size. Small opacity profusion is classified into four categories (0, 1, 2, 3), each divided into three subcategories (0/- to 3/+). ILO profusion scores of 1/0 and above are considered pneumoconiosis. Progressive massive fibrosis (PMF) is defined as a large opacity exceeding 1 cm in diameter assigned to one of three categories according to the ILO International Classification of Radiographs of Pneumoconioses.
Publication 2023
Digital Radiography Ethics Committees Europeans Fibrosis Humidity Lung Medical Devices Nicotiana tabacum Occupational Diseases Occupational Exposure Operative Surgical Procedures Patients Physical Examination Physicians Pneumoconiosis Radiography, Thoracic Respiratory Rate Specialists Spirometry Workers X-Rays, Diagnostic
Tetraethoxysilane (TEOS), cetyltrimethylammonium bromide (CTAB) (3-glycidyloxypropyl) trimethoxysilane (APTES), potassium ferricyanide (K3[Fe(CN)6]), potassium ferrocyanide (K4[Fe(CN)6]), potassium hydrogen phthalate (KHP), norepinephrine (NE), bovine serum albumin (BSA), ascorbic acid (AA), uric acid (UA), folic acid (FA) were obtained from Aladdin (Shanghai, China). L-Cystine and sodium phosphate dibasic dodecahydrate (Na2HPO4.12H2O) were purchased from Macklin (Shanghai, China). Hydrochloric acid was obtained from Hangzhou Shuanglin Chemical reagent (Hangzhou, China). Ethanol, calcium chloride (CaCl2), potassium chloride (KCl), sodium chloride (NaCl), Zinc chloride(ZnCl2), oleic acid (OA) were provided from Hangzhou Gaojing Fine Chemical Industry (Hangzhou, China). Whole human blood (healthy man) was provided by Hangzhou Occupational Disease Prevention and Control Institute (Hangzhou, China) for real sample analysis. Phosphate buffer solution (PBS) was prepared using Na2HPO4 and NaH2PO4 in a certain proportion. All chemicals and reagents are used directly without further purification. Ultrapure water (18.2 MΩ cm) was used throughout the work.
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Publication 2023
Ascorbic Acid BLOOD Buffers Calcium chloride Cetrimonium Bromide Cystine Ethanol Folic Acid Hydrochloric acid Norepinephrine Occupational Diseases Oleic Acid Phosphates potassium ferricyanide potassium ferrocyanide potassium hydrogen phthalate Serum Albumin, Bovine Sodium Chloride sodium phosphate tetraethoxysilane trimethoxysilane Uric Acid zinc chloride
The test compound analyzed in this study was 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (LGC Standards, Wesel, Germany), a persistent organic pollutant and endocrine disruptor compound, and the corresponding highest concentration tested was 25 nM. The rationale for the selection of the test compound was to include a well-known xenobiotic of high relevance for human and environmental health. Therefore, we included TCDD and its concentration from a previous study for in vitro exposures to the human hepatic cell line HepaRG. Concentration selection was based on the translation of external intakes into internal doses in hepatic cells. The external intake estimates from plasma monitored levels or environmental, accidental, and occupational conditions of TCDD were associated with target tissue (liver cells) dosimetry using a generic physiologically based biokinetic model. The highest serum levels observed correspond to an intake of up to 15 ng/kg_bw/d which corresponded to an internal dose in the liver cells of up to 25 nM TCDD [20 (link)].
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Publication 2023
Accidents Endocrine Disruptors Generic Drugs Hepatocyte Homo sapiens Occupational Diseases Persistent Organic Pollutants Plasma Radiometry Serum Tetrachlorodibenzodioxin Tissues Xenobiotics
This retrospective cohort study was conducted on the patient’s recordings from 1 January 2020 to 18 April 2022 at the respiratory department of Aleppo University Hospital, Syria. A total of 174 patients were included in our study; they were referred or hospitalized to our department after diagnosis of ILD. At first, depending on the patient’s recordings, we determined the medical history, clinical findings, and radiographic findings of HRCT scans of the patients accepted in our department as ILD patients. After that, we performed flexible bronchoscopy (Olympus BF type PE2) under local anesthesia using xylocaine (4% spray – 2% instillation through the working channel), then taking an endoscopic TBLB by using disposable biopsy forceps (Olympus, model no. FB-231D, working length: 1150 mm, minimum channel size: 2.0 mm). We followed the guidelines10 (link),11 (link) for flexible fiberoptic bronchoscopy and TBLB, and the biopsy site was selected according to the radiologic lesion location on HRCT. The results of biopsies were studied in the Histopathology Department of Aleppo University Hospital. The process included entering the bronchoscope into the third bronchial branch and then fixing it in position, inserting the forceps until the specialist felt resistance or the patient felt pain; we asked the patient to take a deep inhalation, open the forceps, and then asked the patient to exhale deeply accompanied by closing the forceps. We determined many inclusion and exclusion criteria to select the included patients in our study as the following: Inclusion criteria – referred or hospitalized patients to our department in Aleppo University Hospital and above 18 years, after defining the diagnosis of diffuse parenchymal lung disease depending on HRCT and clinical findings with excluding another respiratory disease such as tuberculosis (TB) and coronavirus disease 2019, etc. Exclusion criteria – patients with a contraindication to conduct bronchoscopy or TBLB such as hypoxia, cardiac arrhythmias, hemorrhage abnormalities, etc. Patients with CT pathognomonic patterns follow the diagnosis criteria of ILD12 (link). Patients with typical manifestations and clinical history of connective tissue disease-associated ILDs, such as rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus, etc. Patients diagnosed with occupational lung disease depend on clinical, radiological, and laboratory examinations. The patients diagnosed with coronavirus disease 2019 depend on nasal smear PCR or TB, depending on the sputum gene Xpert MTP/RIF.
We confirm that the work has been reported in line with the Strengthening The Reporting Of Cohort Studies in Surgery (STROCSS) criteria13 (link).
Publication 2023
Biopsy Bronchi Bronchoscopes Bronchoscopy Cardiac Arrhythmia Congenital Abnormality Connective Tissue COVID 19 Endoscopy Feelings Forceps Genes Hemorrhage Hypoxia Inhalation Local Anesthesia Lung Lung Diseases, Interstitial Lupus Erythematosus, Systemic Nose Occupational Diseases Operative Surgical Procedures Pain Patients Physical Examination Radionuclide Imaging Respiration Disorders Respiratory Rate Rheumatoid Arthritis Signs and Symptoms Sputum Systemic Scleroderma Tuberculosis Tuberculosis, Pulmonary X-Rays, Diagnostic Xylocaine
Annual reports of pneumoconiosis for Zhejiang Province from 2006 to 2020 were extracted from the National Occupational Disease and Occupational Health Information Monitoring System. The system was constructed in 2006, which included the basic information of all confirmed occupational disease cases, such as dates of birth, genders, occupational disease categories, diagnosis dates, exposure durations and employer information. Once a worker was confirmed to have occupational pneumoconiosis by occupational disease diagnostic physicians, an occupational disease notification card will be submitted to the system. All cards uploaded to the system would be reviewed and approved by physicians in centers for disease control and prevention (CDC) at the county/district, city, provincial and national levels, which ensured the comprehensiveness and reliability of the reporting data.
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Publication 2023
Childbirth Diagnosis Disease Notification Occupational Diseases Physicians Pneumoconiosis Workers

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More about "Occupational Diseases"

Occupational Diseases are health conditions caused by exposures or hazards encountered in the workplace.
These can include respiratory illnesses, musculoskeletal disorders, neurological problems, and more.
Identifying effective protocols for studying and managing occupational diseases is crucial for worker health and safety.
PubCompare.ai's AI-driven platform can assist researchers by locating the most impactful literature, preprints, and patents, and comparing approaches to find the most reliable methods.
This can help streamline the research process and achieve more robust, reproducibel results.
Occupational diseases can be caused by a variety of factors, including chemical exposures, physical stressors, biological agents, and psychosocial factors.
Common examples include asbestosis, silicosis, lead poisoning, carpal tunnel syndrome, and work-related stress.
Effective management of occupational diseases requires a multidisciplinary approach, incorporating elements of epidemiology, toxicology, ergonomics, and occupational health.
Tools like SPSS 23.0 can be used to analyze data and identify risk factors, while technologies like Tris(2,2-bipyridine)dichlororuthenium(ii) hexahydrate (Ru(bpy)3Cl2·6H2O) and L-Cystine may be used in laboratory analysis.
Researchers can also leverage resources like Office Excel and Hexaammineruthenium (III) chloride (Ru(NH3)6Cl3) to manage and analyze data, while cell culture techniques using FBS, PI reagent, Silica suspension, Penicillin, and Streptomycin can be employed to study the effects of occupational exposures.
By harnessing the power of PubCompare.ai's AI-driven platform, researchers can streamline their work, identify the most effective protocols, and acheive more reliable, reproducible results in the field of occupational disease research and prevention.