A subcommittee (VM [chair], RH, JP, SW) was formed in the summer of 2010. The goals of the sub-committee were to: (a) review available literature for consensus definitions of AP, ARP, and CP (16 (link)–18 (link)) CP; (b) develop a draft document for circulation to other members of the INSPPIRE group during the fall of 2010; (c) draft a revised document to achieve final consensus at the INSPPIRE meetings in December 2010 and May 2011. The goal of the subcommittee was to develop the definitions that would accurately classify children with pancreatitis, thus create a homogenous population that could be easily phenotyped and included in future prospective studies.
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Pancreatitis
Pancreatitis
Pancreatitis is a condition characterized by inflammation of the pancreas, a digestive organ located behind the stomach.
It can be acute, with sudden onset of symptoms like abdominal pain, nausea, and vomiting, or chronic, with persistent inflammation leading to tissue damage and impaired pancreas function.
Common causes include gallstones, excessive alcohol consumption, and certain medications.
Timely diagnosis and appropriate treatment, such as pain management, fluid therapy, and addressing the underlying cause, are crucial for managing pancreatitis and preventing complications.
Ongoing research aims to improve understanding of the disease mechanisms and develop more effective treatment strategies.
It can be acute, with sudden onset of symptoms like abdominal pain, nausea, and vomiting, or chronic, with persistent inflammation leading to tissue damage and impaired pancreas function.
Common causes include gallstones, excessive alcohol consumption, and certain medications.
Timely diagnosis and appropriate treatment, such as pain management, fluid therapy, and addressing the underlying cause, are crucial for managing pancreatitis and preventing complications.
Ongoing research aims to improve understanding of the disease mechanisms and develop more effective treatment strategies.
Most cited protocols related to «Pancreatitis»
Child
Homozygote
Pancreatitis
Our newly developed search filter for detecting all studies in PubMed in which laboratory animals are used or described was compared with the easily available and most obvious method (‘regular method’), the PubMed Limit: Animals. The number of records obtained with the two different methods was compared. In addition, both the search filter and the limit option were validated by actually performing two PubMed topic searches. The first topic search aimed at finding all available literature in PubMed about probiotic use in experimental pancreatitis (Supplement 1a, available online at http:la.rsmjournals.com/cgi/content/full/la.2010.009117/DC1 ).
The second topic search tried to identify all studies about food restriction in laboratory animals (Supplement 1b, available online athttp:la.rsmjournals.com/cgi/content/full/la.2010.009117/DC1 ).
The number of records found with our search filter as a proportion of the number of records retrieved by the Limit: Animals was calculated. We will refer to this proportion as the sensitivity* of the search filter.
The second topic search tried to identify all studies about food restriction in laboratory animals (Supplement 1b, available online at
The number of records found with our search filter as a proportion of the number of records retrieved by the Limit: Animals was calculated. We will refer to this proportion as the sensitivity* of the search filter.
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Animals
Animals, Laboratory
Dietary Supplements
Feeds, Animal
Food
Hypersensitivity
Pancreatitis
Probiotics
Abdomen
Alleles
Animals
Anophthalmia with pulmonary hypoplasia
Ascites
Carcinoma
Cells
Ceruletide
Dehydration
Dexamethasone
Disease Progression
fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether
Hypertrophy
Mice, Inbred NOD
Mice, Laboratory
Neoplasms
Pancreas
Pancreatitis
Pathologists
PDX1 protein, human
SCID Mice
Strains
Sulfoxide, Dimethyl
Transplantation
Autoantibodies
Cells
Division, Cell
Donors
Eosin
Glucagon
Hematoxylin
Immunohistochemistry
Inflammation
Insulin
Pancreas
Pancreatic alpha Cells
Pancreatic beta Cells
Pancreatitis
Paraffin
Spleen
T-Lymphocyte
Tissue Donors
Acquired Immunodeficiency Syndrome
Acute Disease
African Trypanosomiasis
Appendicitis
Behavior Disorders
Care, Prenatal
Cerebrovascular Accident
Child
Cholera
Chronic Kidney Diseases
Congenital Abnormality
Dementia
Dengue Fever
Disease, Chronic
Drug Abuser
Epilepsy
Households
Injuries
Intellectual Disability
Leprosy
Liver Cirrhosis
Malignant Neoplasms
Measles
Mental Health
Multiple Sclerosis
Myocardial Infarction
Outpatients
Pancreatitis
Patient Discharge
Patients
Pertussis
Pneumoconiosis
Population Group
Projective Techniques
Respiratory Diaphragm
Schistosomiasis
sequels
Skin Diseases
Syphilis
Tuberculosis
Vision
Woman
Yellow Fever
Most recents protocols related to «Pancreatitis»
Literature search was performed in the Web of Science Core Collection (WoSCC) on June 6, 2022, at the Ruijin Hospital affiliated to the Shanghai Jiao Tong University School of Medicine. Thesauruses of AIP were identified in the Medical Subject Headings (MeSH) database (https://www.ncbi.nlm.nih.gov/mesh ) and added to the search query, as follows: TI = (“autoimmune pancreatitis” OR “IgG4-related pancreatitis” OR “lymphoplasmacytic sclerosing pancreatitis” OR “idiopathic duct centric pancreatitis”) OR AB = (“autoimmune pancreatitis” OR “IgG4-related pancreatitis” OR “lymphoplasmacytic sclerosing pancreatitis” OR “idiopathic duct centric pancreatitis”) OR AK = (“autoimmune pancreatitis” OR “IgG4-related pancreatitis” OR “lymphoplasmacytic sclerosing pancreatitis” OR “idiopathic duct centric pancreatitis”). According to our search query, articles that mentioned AIP or its synonyms in the title, abstract, or keywords were identified. The date of publications was set between January 1, 2002, and June 6, 2022, and the type of publications was restricted to articles and review articles. Documents published earlier than January 1, 2002, were excluded. Moreover, case reports, meeting abstracts, editorial materials, and other documents types were excluded. No restriction on languages was applied.
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Autoimmune Pancreatitis
IgG4
Pancreatitis
Type 2 Autoimmune Pancreatitis
The initial screening identified a total of 213 PBM children during a period from January 1, 2015 to December 31, 2021.The inclusion criteria were as follows: (1) possession of pathological results from surgical specimens; (2) completion of surgery within 1 month after MR examination; and (3) availability of complete clinical data. The exclusion criteria were as follows: (1) incomplete clinical or pathological information; (2) patients diagnosed by CT scan alone, without MR scan; or (3) patients whose radiomics features could not be successfully extracted from the MR images. In total, 144 cases were included in the final analysis (Fig. 1 ).![]()
Due to the small number of cases at Xuzhou Children’s Hospital (n = 26), we did not adopt the conventional approach of using cases from one site as training cohort and cases from the other site for external validation. Instead, the 144 cases were randomly split at a 7:3 ratio to a training and a validation cohort. Clinical features considered as candidate variables for the model included sex, age (in years), abdominal pain, jaundice, fever, vomiting, liver dysfunction, pancreatitis, and elevated white blood cell (WBC) count. Liver dysfunction was defined as an elevation in serum aspartate aminotransferase (AST) and serum alanine aminotransferase (ALT) levels, while pancreatitis was defined as a preoperative serum amylase or lipase level of more than threefold the normal upper limit.
Patient recruitment and study design
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Abdominal Pain
Alanine Transaminase
Amylase
Aspartate Transaminase
Child
Fever
Icterus
Leukocyte Count
Lipase
Operative Surgical Procedures
Pancreatitis
Patients
Radionuclide Imaging
Serum
X-Ray Computed Tomography
The initial complaint was divided into five categories: abdominal pain, abdominal discomfort, abdominal trauma, fall trauma, and MVC. Abdominal pain in these categories refers to severe abdominal pain lasting from hours to a few days where the initial approach from the ED physician was to asses for life threatening causes. Abdominal discomfort refers to less serious causes of abdominal pain such as constipation, gastritis, and diverticulosis. Abdominal trauma refers to blunt trauma, impact with an object, or penetrating injuries. Fall traumas refer to blunt traumas from deceleration from different type of falls, and MVC from deceleration from a vehicle impact and collision. We removed two cases that did not fit within these categories. Initial imaging results were categorized as negative or positive. The acute positive result included radiology reports describing infection (appendicitis, colitis, diverticulitis, and pyelonephritis); inflammation (pancreatitis and inflammatory bowel disease), masses and malignancies; and vascular abnormalities (gastrointestinal bleeding, aortic dissection, and abdominal aortic aneurysm). Positive incidental findings were categorized into hernia, cyst, nodule/mass, liver disease, renal calculi/malfunction, gastrointestinal, thoracic/chest cavity, and genitourinary issues.
We noted whether the patient had received any follow-up imaging of the same body region (up to 90 days from initial presentation and imaging). Imaging follow-up type was categorized as CT and magnetic resonance (MR) of the abdomen and pelvis with and without contrast, abdominal ultrasound, abdominal CT angiography (CTA), and abdominal X-ray. Follow-up report status either confirmed findings (negative, acute, and incidental) or identified a missed finding/false adverse finding. A board-certified, abdominal fellowship-trained radiologist re-evaluated reports and associated imaging in order to confirm any missed/false-negative results.
We noted whether the patient had received any follow-up imaging of the same body region (up to 90 days from initial presentation and imaging). Imaging follow-up type was categorized as CT and magnetic resonance (MR) of the abdomen and pelvis with and without contrast, abdominal ultrasound, abdominal CT angiography (CTA), and abdominal X-ray. Follow-up report status either confirmed findings (negative, acute, and incidental) or identified a missed finding/false adverse finding. A board-certified, abdominal fellowship-trained radiologist re-evaluated reports and associated imaging in order to confirm any missed/false-negative results.
Abdomen
Abdominal Cavity
Abdominal Pain
Aortic Aneurysm, Abdominal
Appendicitis
Blood Vessel
Body Regions
Calculi
Chest
Colitis
Computed Tomography Angiography
Congenital Abnormality
Constipation
Cyst
Deceleration
Dissecting Aneurysms
Diverticulitis
Diverticulosis
Equus asinus
Fellowships
Gastritis
Hepatobiliary Disorder
Hernia
Infection
Inflammation
Inflammatory Bowel Diseases
Injury, Abdominal
Kidney Failure
Magnetic Resonance Imaging
Malignant Neoplasms
Nonpenetrating Wounds
Pancreatitis
Patients
Pelvis
Physicians
Pyelonephritis
Radiography
Radiography, Abdominal
Radiologist
System, Genitourinary
Thoracic Cavity
Ultrasonography
Wounds, Penetrating
Wounds and Injuries
The secondary endpoint, which is adverse events related to endoscopic tattooing, such as perforation, abscess formation, peritonitis, post-tattoo fever, post-tattoo abdominal pain, and intraperitoneal spillage of tattooing agent, will be evaluated in autologous blood group. Surgery related complications include peritoneal effusion or abscess formation, hemorrhage (inside abdominal cavity, inside digestive tract), ileus, anastomotic leakage, intestinal fistula, lymphatic leakage, gastroparesis, pancreatitis, lung infection, pleural effusion, urinary tract infection, renal failure, liver failure, cardio-cerebrovascular events (both lower extremities thrombosis, pulmonary embolism, myocardial infarction, arrhythmia, cerebral infarction, etc.), and others. Surgical complications will be evaluated in both groups. Complications will be reported and graded according to the Clavien-Dindo classification of surgical complications.![]()
CONSORT diagram
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Abdominal Cavity
Abdominal Pain
Abscess
Anastomotic Leak
Cardiac Arrhythmia
Cerebral Infarction
Endoscopy
Fever
Gastrointestinal Tract
Gastroparesis
Hemorrhage
Hepatic Insufficiency
Ileus
Infection
Intestinal Fistula
Kidney Failure
Lower Extremity
Lung
Myocardial Infarction
Operative Surgical Procedures
Pancreatitis
Peritoneal Effusion
Peritonitis
Pleural Effusion
Pulmonary Embolism
Thrombosis
Urinary Tract Infection
A total of 95 volunteers were recruited from April 1, 2019 to June 30, 2022, including 36 females (17 T2DM patients, 19 normal controls) and 59 males (30 T2DM patients, 29 normal controls). T2DM Patients ranged from 32 to 71 years old (51.32 ± 10.60). The normal control group ranged from 31 to 68 years old (51.28 ± 8.91). Inclusion criteria: (1) patients diagnosed with T2DM and healthy volunteers with similar age to T2DM patients ( ± 3 years old) and no related diseases. Exclusion criteria: (1) patients unable to participate in MRI examination due to contraindications or other reasons; (2) patients with liver and pancreatic tumors; (3) patients after splenectomy; (4) patients with abnormal metabolic function or metabolic diseases excluding T2DM; (5) patients with hepatitis virus or hepatitis B, and liver iron deposition; (6) patients with liver trauma or patients receiving a liver transplant; (7) patients with pancreatic inflammation and alcoholics; (8) Patients with a history of drug therapy for the the pancreas (Sulfonamides, azathioprine, glucocorticoids, thiazide diuretics) and liver (Platinum agents, antibiotics, alkylating agents, antipsychotics, anti-tuberculosis drugs, and anti-tumor drugs) within six months. This study was conducted in accordance with the principles of the Declaration of Helsinki and approved by the hospital Ethics Committee (NO.2022-E460-01).
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Alcoholics
Alkylating Agents
Antibiotics
Antineoplastic Agents
Antipsychotic Agents
Antitubercular Agents
Azathioprine
Ethics Committees, Clinical
Females
Glucocorticoids
Healthy Volunteers
Hepatitis B
Hepatitis Viruses
Iron
Liver
Liver Transplantations
Males
Metabolic Diseases
Pancreas
Pancreatic Neoplasm
Pancreatitis
Patients
Pharmacotherapy
Platinum
Splenectomy
Sulfonamides
Thiazide Diuretics
Voluntary Workers
Wounds and Injuries
Top products related to «Pancreatitis»
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Caerulein is a laboratory product manufactured by Merck Group. It is a peptide compound used in research applications. Caerulein is primarily utilized as a research tool to study various biological processes and mechanisms.
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Cerulein is a laboratory product manufactured by Merck Group. It is a peptide compound commonly used in research applications to study various biological processes.
Sourced in Switzerland
Caerulein is a synthetic peptide compound used for research and development purposes. It is a structural analog of the naturally occurring hormone cholecystokinin (CCK), which plays a role in the regulation of gastrointestinal functions. The core function of Caerulein is to serve as a research tool for investigating the physiological and pharmacological effects of CCK-related peptides.
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SAS 9.4 is an integrated software suite for advanced analytics, data management, and business intelligence. It provides a comprehensive platform for data analysis, modeling, and reporting. SAS 9.4 offers a wide range of capabilities, including data manipulation, statistical analysis, predictive modeling, and visual data exploration.
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The TJF-260V is a video duodenoscope designed for diagnostic and therapeutic procedures in the upper gastrointestinal tract. It features a slim, flexible insertion tube and a wide, forward-viewing field of view.
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L-arginine is an amino acid that plays a crucial role in various physiological processes. It serves as a substrate for the production of nitric oxide, which is essential for maintaining healthy blood flow and cardiovascular function. This lab equipment product can be utilized for research and scientific applications related to the study of L-arginine and its associated biological functions.
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The JF-260V is a laboratory equipment product manufactured by Olympus. It is a high-quality instrument designed for precise and reliable measurements in various scientific and research applications. The core function of the JF-260V is to provide accurate and reproducible results for the user's specific needs. Further details on the intended use or specific features of the product are not available within the scope of this request.
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C57BL/6 is a widely used inbred mouse strain. It is a robust, readily available laboratory mouse model.
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Amphotericin B is an antifungal agent that is commonly used in cell culture applications. It is effective against a broad spectrum of fungal species and is often used to prevent fungal contamination in cell culture media.
More about "Pancreatitis"
Pancreatitis is a condition characterized by inflammation of the pancreas, a vital digestive organ located behind the stomach.
It can manifest acutely, with sudden onset of symptoms such as abdominal pain, nausea, and vomiting, or chronically, with persistent inflammation leading to tissue damage and impaired pancreas function.
Common etiologies include gallstones, excessive alcohol consumption, certain medications, and exposure to caerulein or cerulein.
Timely diagnosis and appropriate treatment, including pain management, fluid therapy, and addressing the underlying cause, are crucial for managing pancreatitis and preventing complications.
Ongoing research aims to improve understanding of the disease mechanisms and develop more effective treatment strategies, leveraging tools like SAS 9.4, SPSS Statistics, and animal models such as the C57BL/6 mouse.
Pancreatitis can also be induced experimentally using agents like L-arginine and Amphotericin B, which can help researchers study the disease pathogenesis and test new therapeutic approaches, as facilitated by advanced tools like the TJF-260V and JF-260V endoscopes.
By optimizing research protocols and ensuring reproducibility, studies on pancreatitis can lead to improved patient outcomes and better management of this complex condition.
It can manifest acutely, with sudden onset of symptoms such as abdominal pain, nausea, and vomiting, or chronically, with persistent inflammation leading to tissue damage and impaired pancreas function.
Common etiologies include gallstones, excessive alcohol consumption, certain medications, and exposure to caerulein or cerulein.
Timely diagnosis and appropriate treatment, including pain management, fluid therapy, and addressing the underlying cause, are crucial for managing pancreatitis and preventing complications.
Ongoing research aims to improve understanding of the disease mechanisms and develop more effective treatment strategies, leveraging tools like SAS 9.4, SPSS Statistics, and animal models such as the C57BL/6 mouse.
Pancreatitis can also be induced experimentally using agents like L-arginine and Amphotericin B, which can help researchers study the disease pathogenesis and test new therapeutic approaches, as facilitated by advanced tools like the TJF-260V and JF-260V endoscopes.
By optimizing research protocols and ensuring reproducibility, studies on pancreatitis can lead to improved patient outcomes and better management of this complex condition.