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Pancreatitis

Pancreatitis is a condition characterized by inflammation of the pancreas, a digestive organ located behind the stomach.
It can be acute, with sudden onset of symptoms like abdominal pain, nausea, and vomiting, or chronic, with persistent inflammation leading to tissue damage and impaired pancreas function.
Common causes include gallstones, excessive alcohol consumption, and certain medications.
Timely diagnosis and appropriate treatment, such as pain management, fluid therapy, and addressing the underlying cause, are crucial for managing pancreatitis and preventing complications.
Ongoing research aims to improve understanding of the disease mechanisms and develop more effective treatment strategies.

Most cited protocols related to «Pancreatitis»

A subcommittee (VM [chair], RH, JP, SW) was formed in the summer of 2010. The goals of the sub-committee were to: (a) review available literature for consensus definitions of AP, ARP, and CP (16 (link)–18 (link)) CP; (b) develop a draft document for circulation to other members of the INSPPIRE group during the fall of 2010; (c) draft a revised document to achieve final consensus at the INSPPIRE meetings in December 2010 and May 2011. The goal of the subcommittee was to develop the definitions that would accurately classify children with pancreatitis, thus create a homogenous population that could be easily phenotyped and included in future prospective studies.
Publication 2012
Child Homozygote Pancreatitis
Our newly developed search filter for detecting all studies in PubMed in which laboratory animals are used or described was compared with the easily available and most obvious method (‘regular method’), the PubMed Limit: Animals. The number of records obtained with the two different methods was compared. In addition, both the search filter and the limit option were validated by actually performing two PubMed topic searches. The first topic search aimed at finding all available literature in PubMed about probiotic use in experimental pancreatitis (Supplement 1a, available online at http:la.rsmjournals.com/cgi/content/full/la.2010.009117/DC1 ).
The second topic search tried to identify all studies about food restriction in laboratory animals (Supplement 1b, available online at http:la.rsmjournals.com/cgi/content/full/la.2010.009117/DC1 ).
The number of records found with our search filter as a proportion of the number of records retrieved by the Limit: Animals was calculated. We will refer to this proportion as the sensitivity* of the search filter.
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Publication 2010
Animals Animals, Laboratory Dietary Supplements Feeds, Animal Food Hypersensitivity Pancreatitis Probiotics

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Publication 2012
Abdomen Alleles Animals Anophthalmia with pulmonary hypoplasia Ascites Carcinoma Cells Ceruletide Dehydration Dexamethasone Disease Progression fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether Hypertrophy Mice, Inbred NOD Mice, Laboratory Neoplasms Pancreas Pancreatitis Pathologists PDX1 protein, human SCID Mice Strains Sulfoxide, Dimethyl Transplantation
Six pancreas (two from each region) and one spleen paraffin block from each donor were serially sectioned and stained by hematoxylin and eosin (H&E) and immunohistochemistry. Two double immunohistochemistry stains were used to identify cell replication (Ki67) and β-cells (insulin), or T cell infiltration (CD3) and alpha cells (glucagon) according to published methods (14 (link)). Histopathological review was conducted with an emphasis on islet morphology, size, and numbers, alpha- and β-cell composition, and presence of inflammation (i.e., insulitis, pancreatitis). Insulitis was distinguished by the presence of 6 or more CD3+ cells adjacent to or within an islet. Stained slides were digitized by whole slide scanning using an Aperio CS scanner and were organized by each donor using the Spectrum Plus information management system (version 11, Aperio, Vista, CA). All paraffin blocks from the autoantibody positive donors were reviewed for the presence of insulitis following H&E staining.
Publication 2012
Autoantibodies Cells Division, Cell Donors Eosin Glucagon Hematoxylin Immunohistochemistry Inflammation Insulin Pancreas Pancreatic alpha Cells Pancreatic beta Cells Pancreatitis Paraffin Spleen T-Lymphocyte Tissue Donors

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Publication 2012
Acquired Immunodeficiency Syndrome Acute Disease African Trypanosomiasis Appendicitis Behavior Disorders Care, Prenatal Cerebrovascular Accident Child Cholera Chronic Kidney Diseases Congenital Abnormality Dementia Dengue Fever Disease, Chronic Drug Abuser Epilepsy Households Injuries Intellectual Disability Leprosy Liver Cirrhosis Malignant Neoplasms Measles Mental Health Multiple Sclerosis Myocardial Infarction Outpatients Pancreatitis Patient Discharge Patients Pertussis Pneumoconiosis Population Group Projective Techniques Respiratory Diaphragm Schistosomiasis sequels Skin Diseases Syphilis Tuberculosis Vision Woman Yellow Fever

Most recents protocols related to «Pancreatitis»

Literature search was performed in the Web of Science Core Collection (WoSCC) on June 6, 2022, at the Ruijin Hospital affiliated to the Shanghai Jiao Tong University School of Medicine. Thesauruses of AIP were identified in the Medical Subject Headings (MeSH) database (https://www.ncbi.nlm.nih.gov/mesh) and added to the search query, as follows: TI = (“autoimmune pancreatitis” OR “IgG4-related pancreatitis” OR “lymphoplasmacytic sclerosing pancreatitis” OR “idiopathic duct centric pancreatitis”) OR AB = (“autoimmune pancreatitis” OR “IgG4-related pancreatitis” OR “lymphoplasmacytic sclerosing pancreatitis” OR “idiopathic duct centric pancreatitis”) OR AK = (“autoimmune pancreatitis” OR “IgG4-related pancreatitis” OR “lymphoplasmacytic sclerosing pancreatitis” OR “idiopathic duct centric pancreatitis”). According to our search query, articles that mentioned AIP or its synonyms in the title, abstract, or keywords were identified. The date of publications was set between January 1, 2002, and June 6, 2022, and the type of publications was restricted to articles and review articles. Documents published earlier than January 1, 2002, were excluded. Moreover, case reports, meeting abstracts, editorial materials, and other documents types were excluded. No restriction on languages was applied.
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Publication 2023
Autoimmune Pancreatitis IgG4 Pancreatitis Type 2 Autoimmune Pancreatitis
The initial screening identified a total of 213 PBM children during a period from January 1, 2015 to December 31, 2021.The inclusion criteria were as follows: (1) possession of pathological results from surgical specimens; (2) completion of surgery within 1 month after MR examination; and (3) availability of complete clinical data. The exclusion criteria were as follows: (1) incomplete clinical or pathological information; (2) patients diagnosed by CT scan alone, without MR scan; or (3) patients whose radiomics features could not be successfully extracted from the MR images. In total, 144 cases were included in the final analysis (Fig. 1).

Patient recruitment and study design

Due to the small number of cases at Xuzhou Children’s Hospital (n = 26), we did not adopt the conventional approach of using cases from one site as training cohort and cases from the other site for external validation. Instead, the 144 cases were randomly split at a 7:3 ratio to a training and a validation cohort. Clinical features considered as candidate variables for the model included sex, age (in years), abdominal pain, jaundice, fever, vomiting, liver dysfunction, pancreatitis, and elevated white blood cell (WBC) count. Liver dysfunction was defined as an elevation in serum aspartate aminotransferase (AST) and serum alanine aminotransferase (ALT) levels, while pancreatitis was defined as a preoperative serum amylase or lipase level of more than threefold the normal upper limit.
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Publication 2023
Abdominal Pain Alanine Transaminase Amylase Aspartate Transaminase Child Fever Icterus Leukocyte Count Lipase Operative Surgical Procedures Pancreatitis Patients Radionuclide Imaging Serum X-Ray Computed Tomography
The initial complaint was divided into five categories: abdominal pain, abdominal discomfort, abdominal trauma, fall trauma, and MVC. Abdominal pain in these categories refers to severe abdominal pain lasting from hours to a few days where the initial approach from the ED physician was to asses for life threatening causes. Abdominal discomfort refers to less serious causes of abdominal pain such as constipation, gastritis, and diverticulosis. Abdominal trauma refers to blunt trauma, impact with an object, or penetrating injuries. Fall traumas refer to blunt traumas from deceleration from different type of falls, and MVC from deceleration from a vehicle impact and collision. We removed two cases that did not fit within these categories. Initial imaging results were categorized as negative or positive. The acute positive result included radiology reports describing infection (appendicitis, colitis, diverticulitis, and pyelonephritis); inflammation (pancreatitis and inflammatory bowel disease), masses and malignancies; and vascular abnormalities (gastrointestinal bleeding, aortic dissection, and abdominal aortic aneurysm). Positive incidental findings were categorized into hernia, cyst, nodule/mass, liver disease, renal calculi/malfunction, gastrointestinal, thoracic/chest cavity, and genitourinary issues.
We noted whether the patient had received any follow-up imaging of the same body region (up to 90 days from initial presentation and imaging). Imaging follow-up type was categorized as CT and magnetic resonance (MR) of the abdomen and pelvis with and without contrast, abdominal ultrasound, abdominal CT angiography (CTA), and abdominal X-ray. Follow-up report status either confirmed findings (negative, acute, and incidental) or identified a missed finding/false adverse finding. A board-certified, abdominal fellowship-trained radiologist re-evaluated reports and associated imaging in order to confirm any missed/false-negative results.
Publication 2023
Abdomen Abdominal Cavity Abdominal Pain Aortic Aneurysm, Abdominal Appendicitis Blood Vessel Body Regions Calculi Chest Colitis Computed Tomography Angiography Congenital Abnormality Constipation Cyst Deceleration Dissecting Aneurysms Diverticulitis Diverticulosis Equus asinus Fellowships Gastritis Hepatobiliary Disorder Hernia Infection Inflammation Inflammatory Bowel Diseases Injury, Abdominal Kidney Failure Magnetic Resonance Imaging Malignant Neoplasms Nonpenetrating Wounds Pancreatitis Patients Pelvis Physicians Pyelonephritis Radiography Radiography, Abdominal Radiologist System, Genitourinary Thoracic Cavity Ultrasonography Wounds, Penetrating Wounds and Injuries
The secondary endpoint, which is adverse events related to endoscopic tattooing, such as perforation, abscess formation, peritonitis, post-tattoo fever, post-tattoo abdominal pain, and intraperitoneal spillage of tattooing agent, will be evaluated in autologous blood group. Surgery related complications include peritoneal effusion or abscess formation, hemorrhage (inside abdominal cavity, inside digestive tract), ileus, anastomotic leakage, intestinal fistula, lymphatic leakage, gastroparesis, pancreatitis, lung infection, pleural effusion, urinary tract infection, renal failure, liver failure, cardio-cerebrovascular events (both lower extremities thrombosis, pulmonary embolism, myocardial infarction, arrhythmia, cerebral infarction, etc.), and others. Surgical complications will be evaluated in both groups. Complications will be reported and graded according to the Clavien-Dindo classification of surgical complications.

CONSORT diagram

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Publication 2023
Abdominal Cavity Abdominal Pain Abscess Anastomotic Leak Cardiac Arrhythmia Cerebral Infarction Endoscopy Fever Gastrointestinal Tract Gastroparesis Hemorrhage Hepatic Insufficiency Ileus Infection Intestinal Fistula Kidney Failure Lower Extremity Lung Myocardial Infarction Operative Surgical Procedures Pancreatitis Peritoneal Effusion Peritonitis Pleural Effusion Pulmonary Embolism Thrombosis Urinary Tract Infection
A total of 95 volunteers were recruited from April 1, 2019 to June 30, 2022, including 36 females (17 T2DM patients, 19 normal controls) and 59 males (30 T2DM patients, 29 normal controls). T2DM Patients ranged from 32 to 71 years old (51.32 ± 10.60). The normal control group ranged from 31 to 68 years old (51.28 ± 8.91). Inclusion criteria: (1) patients diagnosed with T2DM and healthy volunteers with similar age to T2DM patients ( ± 3 years old) and no related diseases. Exclusion criteria: (1) patients unable to participate in MRI examination due to contraindications or other reasons; (2) patients with liver and pancreatic tumors; (3) patients after splenectomy; (4) patients with abnormal metabolic function or metabolic diseases excluding T2DM; (5) patients with hepatitis virus or hepatitis B, and liver iron deposition; (6) patients with liver trauma or patients receiving a liver transplant; (7) patients with pancreatic inflammation and alcoholics; (8) Patients with a history of drug therapy for the the pancreas (Sulfonamides, azathioprine, glucocorticoids, thiazide diuretics) and liver (Platinum agents, antibiotics, alkylating agents, antipsychotics, anti-tuberculosis drugs, and anti-tumor drugs) within six months. This study was conducted in accordance with the principles of the Declaration of Helsinki and approved by the hospital Ethics Committee (NO.2022-E460-01).
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Publication 2023
Alcoholics Alkylating Agents Antibiotics Antineoplastic Agents Antipsychotic Agents Antitubercular Agents Azathioprine Ethics Committees, Clinical Females Glucocorticoids Healthy Volunteers Hepatitis B Hepatitis Viruses Iron Liver Liver Transplantations Males Metabolic Diseases Pancreas Pancreatic Neoplasm Pancreatitis Patients Pharmacotherapy Platinum Splenectomy Sulfonamides Thiazide Diuretics Voluntary Workers Wounds and Injuries

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More about "Pancreatitis"

Pancreatitis is a condition characterized by inflammation of the pancreas, a vital digestive organ located behind the stomach.
It can manifest acutely, with sudden onset of symptoms such as abdominal pain, nausea, and vomiting, or chronically, with persistent inflammation leading to tissue damage and impaired pancreas function.
Common etiologies include gallstones, excessive alcohol consumption, certain medications, and exposure to caerulein or cerulein.
Timely diagnosis and appropriate treatment, including pain management, fluid therapy, and addressing the underlying cause, are crucial for managing pancreatitis and preventing complications.
Ongoing research aims to improve understanding of the disease mechanisms and develop more effective treatment strategies, leveraging tools like SAS 9.4, SPSS Statistics, and animal models such as the C57BL/6 mouse.
Pancreatitis can also be induced experimentally using agents like L-arginine and Amphotericin B, which can help researchers study the disease pathogenesis and test new therapeutic approaches, as facilitated by advanced tools like the TJF-260V and JF-260V endoscopes.
By optimizing research protocols and ensuring reproducibility, studies on pancreatitis can lead to improved patient outcomes and better management of this complex condition.