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Prolapse

Prolapse refers to the abnormal descent or protrusion of an organ or part of an organ through the natural body opening or through an abnormal opening in the body wall.
This can occur in various parts of the body, such as the uterus (uterine prolapse), bladder (cystocele), rectum (rectal prolapse), or other pelvic organs.
Prolapse can result from weakening of the supporting structures or increased pressure within the body cavity.
Symptoms may include a feeling of pressure, discomfort, or the sensation of a bulge or lump.
Proper diagnosis and treatment, which may involve conservative measures or surgical intervention, are important to manage prolapse and prevent further complications.
Reseachers can leverage AI-driven tools like PubCompare.ai to identify the best protocols for prolapse research and enhance reproducibility and accuraacy.

Most cited protocols related to «Prolapse»

We analyzed data from 322 women who completed 2-year follow-up in the CARE trial, a randomized trial designed to evaluate whether a standardized modified Burch colposuspension, when added to abdominal sacrocolpopexy to treat POP, improves urinary stress continence in women without preoperative symptoms of stress urinary incontinence.10 (link), 11 (link) Each clinical site and the data coordinating center received institutional review board approval for this trial, and all participants provided written informed consent.
The methods and primary outcomes of this trial have been previously reported.10 (link),11 (link) Colpopexy and Urinary Reduction Efforts trial participants were assessed before surgery and at 2-year follow-up for pelvic organ support using the POP-Q.4 (link) In addition, pelvic symptoms and severity (Pelvic Floor Distress Inventory) along with condition-specific life impact (Pelvic Floor Impact Questionnaire) were measured via validated instruments.12 (link) Two years after surgery, women rated the overall success of their treatment (“In your opinion, has the treatment of your pelvic floor condition been _______?”) on a 4-point scale (very successful, moderately successful, somewhat successful, not at all successful) and similarly a global assessment of improvement (“Compared with how you were doing before your recent pelvic floor operation, would you say that now you are _______?”) on a 5-point scale (much better, a little better, about the same, a little worse, much worse).
We created 18 different definitions of surgical success by using POP-Q assessments, responses to Pelvic Floor Distress Inventory questions regarding vaginal bulging, data on re-treatment (surgery or pessary), and participant’s subjective ratings of overall treatment success and global improvement as listed in Table 1. The proposed definitions of treatment success consist of those recommended in the NIH Standardization Workshop and several used by clinical trials or prospective cohorts evaluating treatment success after prolapse surgery including one from an ongoing clinical trial being conducted by the Pelvic Floor Disorders Network (the OPTIMAL Trial).1 ,2 (link),7 (link)–9 (link),13 (link)
Definitions assessing anatomic outcomes used POP-Q measurements at 2-year follow-up to define treatment success or failure. To evaluate definitions that used the Baden-Walker system,14 (link) POP-Q measurements were used to approximate Baden-Walker grades 0–3. For instance, treatment success defined as Baden-Walker grade 0, 1, or 2 translates into “no descent of the vaginal walls beyond the hymen” or POP-Q measurements Ba, Bp, and C less than or equal to 0. Treatment success defined as Baden-Walker grade 0 or 1 corresponds to “no vaginal descent beyond the half-way point of the vagina.” For the apex, this translates into a POP-Q measurement of point C that does not descend more than one-half the total vaginal length (Point C less than or equal to 1/2 total vaginal length). For the anterior and posterior vaginal segments, there is no obvious direct translation to POP-Q measurements, so we assigned the criteria for success for the anterior/posterior segments as Bp and Ba less than −1 for this definition of treatment success to best approximate the Baden-Walker system.
Subjective cure was defined as the absence of vaginal bulge symptoms as indicated by a negative response at 2-year follow-up to the questions “Do you usually have a sensation of bulging or protrusion from the vaginal area?” and “Do you usually have a bulge or something falling out that you can see or feel in the vaginal area?” from the Pelvic Floor Distress Inventory.12 (link) We chose this definition of subjective cure as the patient’s ability to see or feel a vaginal bulge as the symptom most consistently related to the presence or absence of POP.15 (link)
Re-treatment for POP was defined as any reoperation or use of pessary for recurrent POP over the 2-year follow-up period. Definitions of treatment success compositing anatomic outcomes, subjective cure, and/or re-treatment were also considered.
For each of 18 dichotomous definitions of treatment success, the proportion of women who had a successful outcome was reported for all analyzed CARE women. This cure rate was further compared between the women who received a Burch colposuspension and those who did not for each proposed definition by using χ2 or Fisher exact test. Additionally, the proportion of women with missing data that precluded a determination of success or failure for each definition was also determined. To evaluate the clinical relevance of each definition from a patient’s perspective, we examined the relationship of subjective assessment of treatment success and the global impression of improvement to different definitions of surgical treatment success by comparing the assessments between those who met the criteria of treatment success to those who did not. Likewise, the comparisons between surgical success and failure groups were performed on the scores of the prolapse scales of the Pelvic Floor Distress Inventory and Pelvic Floor Impact Questionnaire (Pelvic Organ Prolapse Distress Inventory and Pelvic Organ Prolapse Impact Questionnaire). A clinically relevant definition of surgical success should demonstrate significantly better global impression of improvement, lower symptom bother (lower Pelvic Floor Distress Inventory scores), and higher health-related quality of life (lower Pelvic Floor Impact Questionnaire scores) in treatment successes than in failures. Mean and standard deviation were reported for the ordinal outcomes of subjective assessments and Pelvic Organ Prolapse Distress Inventory and Pelvic Organ Prolapse Impact Questionnaire scores, and the Wilcoxon rank sum test was used to identify any significant difference in outcomes between success and failure. All reported P values were based on the two-sided statistical tests and intended to be interpreted from a hypothesis-generating framework. The analyses were performed in SAS 9.1.3 for Windows (SAS Inc., Cary, NC).
Publication 2009
Abdomen Ethics Committees, Research Feelings Follow-Up Care Hymen Operative Surgical Procedures Patients Pelvic Diaphragm Pelvic Floor Disorders Pelvic Organ Prolapse Pelvis Pessaries Prolapse Second Look Surgery Syncope Urinary Stress Incontinence Urine Vagina Walkers Woman
Participants underwent transvaginal surgery for pelvic organ prolapse, including the assigned apical suspension procedure. The SSLF procedure, performed unilaterally, was a modification of the Michigan 4-wall technique.19 (link),20 The ULS procedure, performed bilaterally, was a modification of the technique described by Shull.21 (link) Both apical suspension procedures used two permanent and two delayed absorbable sutures (four sutures total).17 (link) All patients with uterine prolapse underwent vaginal hysterectomy. A concomitant retropubic mid-urethral sling (Tension-Free Vaginal Tape [TVT®]; Ethicon Women’s Health and Urology, Somerville, NJ) was performed for stress urinary incontinence. Other concomitant surgeries were performed at the surgeon’s discretion; biologic or synthetic graft materials were not allowed for the prolapse repairs.
Usual perioperative care included routine perioperative teaching and standardized postoperative instructions. Participants randomized to perioperative BPMT received an individualized program that included one visit 2–4 weeks prior to surgery, and four post-operative visits (2, 4–6, 8, and 12 weeks after surgery).17 (link) (eTable 2) Pelvic floor muscle training, individualized progressive pelvic floor muscle exercise, and education on behavioral strategies to reduce urinary and colorectal symptoms were performed at each visit. Self-reported adherence to BPMT was assessed at 6, 12, and 24 months. All BPMT interventionists attended centralized in-person training prior to the initiation of the study.
Data collection occurred at baseline, during surgery and hospitalization, and at regular intervals up to 24 months postoperatively with Pelvic Organ Prolapse Quantification (POPQ)18 (link) evaluations and symptom assessments occurring at 6, 12 and 24 months. BPMT interventionists were masked to surgical randomization. All outcome assessors were masked to both perioperative BPMT and surgical intervention assignment, including research personnel who conducted vaginal examinations and trained telephone interviewers who administered patient reported outcomes from a centralized facility. Participants were masked to the surgical group assignment, and study surgeons were masked to perioperative BPMT group assignment.
Publication 2014
Biopharmaceuticals Grafts Hospitalization Interviewers Muscle Tissue Operative Surgical Procedures Patients Pelvic Diaphragm Pelvic Organ Prolapse Perioperative Care Prolapse Surgeons Sutures Symptom Assessment Tensionless Vaginal Tape Urinary Stress Incontinence Urine Uterine Prolapse Vaginal Examination Vaginal Hysterectomy Woman Wound Healing

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Publication 2008
Brief Interventions Ethics Committees, Research Muscle Tissue Operative Surgical Procedures Pain, Postoperative Pelvic Organ Prolapse Perioperative Care Prolapse Surgeons Tensionless Vaginal Tape Urologic Surgical Procedures Uterus Vagina Vaginal Prolapse Vaginal Vault Prolapse Woman
Following Loyola University Medical Center (LUMC) Institutional Review Board approval, participants gave verbal and written consent for chart abstraction and urine collection with analysis for research purposes. Recruitment and urine collection was performed by members of the Loyola Urinary Education and Research Collaborative who are part of the clinical practice of the Female Pelvic Medicine and Reconstructive Surgery Center at LUMC. Exclusion criteria for both cohorts included current UTI (based on urine dipstick) or history of recurrent UTI, antibiotic exposure in the past 4 weeks for any reason, immunologic deficiency, neurological disease known to affect the lower urinary tract, pelvic malignancy or radiation, untreated symptomatic pelvic organ prolapse (POP) greater than POP-Q stage II (vaginal protrusion >1 cm outside of the vaginal hymen), or pregnancy.
Patients were recruited as part of separate studies2 (link),9 (link),27 (link)–29 (link). In the current study, representative isolates were selected for whole-genome sequencing in order to build as phylogenetically complete a dataset as possible. For this reason, only a few isolates from some patients have been included. For complete understanding of each patient’s microbiome or for additional metadata, please refer to the primary publications listed in Supplementary Data 1.
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Publication 2018
Antibiotics Ethics Committees, Research Hymen Immunologic Deficiency Syndromes Microbiome Nervous System Disorder Patients Pelvic Cancer Pelvic Organ Prolapse Pelvis Pregnancy Prolapse Radiotherapy Reconstructive Surgical Procedures Urinalysis Urinary Tract Urine Urine Specimen Collection Vagina Woman
The presence or absence of pelvic floor disorders was evaluated at the enrollment visit. Symptoms of pelvic floor disorders were assessed using the Epidemiology of Prolapse and Incontinence Questionnaire, a validated self-administered questionnaire (14 (link)). This questionnaire generates scores for four pelvic floor disorders: stress urinary incontinence (SUI), overactive bladder (OAB), anal incontinence and pelvic organ prolapse (POP). In each case, a validated threshold is used to define women who meet criteria for the disorder. Scores greater than these threshold values have been shown to correspond to significant bother from pelvic floor symptoms (14 (link)). In this research, we used the published thresholds (14 (link)) to distinguish women with and without each pelvic floor disorder.
In addition to the research questionnaire, a gynecological examination was performed to assess pelvic organ support, using the Pelvic Organ Prolapse Quantification examination system (15 (link)). The examination was performed by physicians and a research nurse, each of whom demonstrated competency in performing the research examination prior to the study; competency was reconfirmed throughout the study. Women were classified as having objective evidence of prolapse if the most dependent point of the vaginal wall or the cervix came to or beyond the hymen (13 (link),16 (link),17 (link)).
At enrollment into our cohort study, participants were asked about prior treatment for pelvic floor disorders, including surgery. Participants were also asked about current therapy, including medications for urinary incontinence or current pessary use for treatment of prolapse. We also considered current or prior pelvic muscle exercises, but only if the program was supervised by a therapist. For the purposes of this analysis, women who reported prior surgery, prior supervised pelvic muscle exercises, or any current therapy for a specific pelvic floor disorder were considered to have that condition, regardless of current symptoms.
Publication 2011
Cervix Uteri Fecal Incontinence Gynecological Examination Hymen Muscle Tissue Nurses Operative Surgical Procedures Overactive Bladder Pelvic Diaphragm Pelvic Floor Disorders Pelvic Organ Prolapse Pelvis Pessaries Pharmaceutical Preparations Physicians Prolapse Therapeutics Urinary Incontinence Urinary Stress Incontinence Vagina Woman

Most recents protocols related to «Prolapse»

In general, the perineal approach to rectal prolapse is performed in fragile patients who cannot tolerate the abdominal approach, such as elderly patients, patients with severe heart or lung disease, patients at high risk of general anesthesia, or patients with a history of abdominal surgery. The authors performed Delorme procedure, Altemeier procedure, and the stapled transanal rectal resection (STARR) procedure through a perineal approach, depending on the degree of rectal prolapse. The STARR procedure was used for mucosal prolapses less than 3 cm from the anus, Delorme procedure for prolapses larger than 3 cm, and Altemeier procedure for full-thickness prolapses.
Publication 2023
Abdomen Aged Anus General Anesthesia Heart Lung Diseases Mucous Membrane Operative Surgical Procedures Patients Perineum Proctectomy Prolapse Rectal Prolapse
Tobramycin/dexamethasone ointment was applied to all suture lines four times a day for the first week and then at bedtime for the second week after surgery. A patch was applied for the first 24 h and a shield was worn at bedtime for the first month following surgery. Patients were followed closely, ideally with appointments at 1 day (Figure 1D with acute ptosis), 1 week (Figure 1E), 1 month, 3 months (Figure 1F), 6 months, and 1 year after the operation. The mean follow-up period was 28 months for this case series (Table 1), and some patients were seen beyond the data collection period with no concerns. Non-identifying pictures were taken of the eyelid at each follow-up to assess for structural integrity, appearance, and viability of the autograft. Phases of healing were documented. Photos were subsequently assessed by all authors.
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Publication 2023
Eyelids Ointments Patients Prolapse Sutures Tobramycin, Dexamethasone Drug Combination Transplantation, Autologous Vision
In addition to the determination of brain CHT ubiquitination levels and concentrations of cytokines and chemokines (below) in STs and GTs, the effects of activation of the innate immune system by the bacterial endotoxin lipopolysaccharide (LPS) were assessed. LPS, from Escherichia coli (serotype O111:B4), was obtained from Millipore Sigma and suspended in 0.9% saline (Teknova 0.9% sterile saline solution; Fisher Scientific) vortexed, allocated to 1.0 mg/ml, and stored in 1.5 ml Eppendorf tubes at −20°C until used. Preparation and injections of LPS were conducted in a chemical fume hood and using procedures approved by the University of Michigan Environment, Health and Safety Department.
STs and GTs were randomly assigned to the administration of LPS (1.0 or 5.0 mg/kg in 0.2 ml saline, i.p.) or 0.9% saline. Sickness behaviors, including piloerection, ptosis, lethargy, and huddling were monitored each hour for 6 h following the treatment injection. A lethal dose of sodium pentobarbital was administered (1.5 g/kg, i.p.) 6 h after injections, followed by transcardiac perfusion with 0.9% saline. The right frontal cortex and right striatum were dissected out and synaptosomal pellets were prepared for determination of CHT ubiquitination levels as described above. Furthermore, spleen, left frontal cortex, and left striatum were harvested, flash-frozen in 2-methyl butane, and stored at −80°C for subsequent determination of cytokine and chemokine levels.
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Publication 2023
Brain Chemokine Cytokine Endotoxins Escherichia coli Freezing isopentane Lethargy Lipopolysaccharides Lobe, Frontal Normal Saline Pellets, Drug Pentobarbital Sodium Perfusion Piloerection Prolapse Safety Saline Solution Spleen Sterility, Reproductive Striatum, Corpus Synaptosomes System, Immune Ubiquitination
It was a retrospective, controlled, monocentric, multi-operator study carried out at the Rothschild Foundation Hospital in Paris concerning patients operated for cataract surgery with Surgicube® versus a cohort of patients operated in a standard theater. The inclusion criteria for both groups were as follows: must be an adult and must be eligible for the pure topical protocol (no sedation and no other anesthesia except topical anesthesia). The patients were operated on between February 2020 and February 2021 with the Surgicube® or in the conventional theater. We used a “date randomization.” Only patients planned with topical anesthesia only have been selected for this study. Each patient chooses the operating day. Following our general theater planning, some patients were admitted to the classic theater and some others to the Surgicube, according to the day they had chosen. Patients with a postoperative follow-up of less than 1 month were excluded. A total number of 93 patients has been excluded. Patient follow-up was carried out by ophthalmologists. For each patient, data were collected from the medical file of the Adolphe de Rothschild Foundation up to 1 month postoperatively. The data collected are as follows: visual acuity, ocular tone, and the presence and type of preoperative and postoperative complications (posterior capsular rupture with or without vitreous loss, intraoperative iris floppy syndrome or iris prolapse, iris or ciliary body injury, lens materials dropped into vitreous, suprachoroidal effusion with or without hemorrhage, transiently elevated intraocular pressure, cornea edema, toxic anterior segment syndrome, endophthalmitis, retained lens materials, hyphema, and Irvin–Gass syndrome).
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Publication 2023
Adult Capsule Cataract Extraction Ciliary Body Edema, Corneal Endophthalmitis Eye Gases Hemorrhage Hyphema Injuries Iris Lens, Crystalline Ophthalmologists Patients Postoperative Complications Pressures, Intraocular Prolapse Sedatives Syndrome Topical Anesthetics Visual Acuity
Data regarding demographics (age, BMI, height, weight, bra size, smoking status, comorbidities, parity), implant characteristics (volume, manufacturer, type, texture, shape), surgical technique (incision/approach, plane, placement, operative time), postoperative complications [dehiscence/exposure, hematoma, infection, implant rotation, implant rupture, seroma (late), asymmetry, capsular contracture, hypertrophic/wide scarring, nipple areolar complex asymmetry, ptosis, and excess skin laxity], reoperation rate, and follow-up times were recorded. Patients unhappy with their result due to personal preference (fear of breast implant-associated anaplastic large cell lymphoma, hyperplasia, hypoplasia, and/or pain) were also recorded. Late seroma was defined as occurring more than 12 months postoperatively.10 (link)–12 The complication category of “asymmetry” included implant displacement (bottoming out or laterally), double bubble, contour deformity, high riding implants, low inframmamary fold, and rippling. The frequency of complications was computed in regard to breasts affected.
Publication 2023
Areola Breast Capsule CD30+ Anaplastic Large Cell Lymphoma Congenital Abnormality Contracture Cutis Laxa Fear Hematoma Hyperplasia hypoplasia Implantations, Breast Infection Nipples Operative Surgical Procedures Pain Patients Postoperative Complications Prolapse Repeat Surgery Sadness Seroma

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More about "Prolapse"

Prolapse, a medical condition characterized by the abnormal descent or protrusion of an organ or body part, can occur in various areas of the body such as the uterus (uterine prolapse), bladder (cystocele), or rectum (rectal prolapse).
This condition may result from weakened supporting structures or increased pressure within the body cavity, leading to symptoms like a feeling of pressure, discomfort, or the sensation of a bulge or lump.
Proper diagnosis and treatment, which may involve conservative measures or surgical intervention, are crucial to manage prolapse and prevent further complications.
Researchers can leverage AI-driven tools like PubCompare.ai to identify the best protocols for prolapse research and enhance reproducibility and accuracy.
PubCompare.ai can help researchers locate the most effective and reproducible protocols from literature, preprints, and patents, enabling them to optimize their prolapse research.
The platform's intelligent analysis can also assist in identifying the optimal products and procedures, such as those from MATLAB, SPSS version 20, SAS version 9.4, LSL-KrasG12D, SPSS version 28, ColoScreen III Lab Pack, SPSS system, SAS 9.4, LSL-Trp53R172H, and CometSlide assay kits, to enhance the accuracy and reproducibility of their studies.
By incorporating these insights and leveraging the power of AI-driven tools, researchers can advance their understanding of prolapse and develop more effective treatment strategies, ultimately improving patient outcomes.