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Transient Ischemic Attack

Transient Ischemic Attack (TIA) is a brief episode of neurological dysfunction caused by a temporary reduction in blood flow to the brain or retina, without permanent tissue damage.
TIAs are often considered a warning sign of a potential future stroke and require prompt medical attention.
Symptoms may include sudden numbness or weakness, difficulty speaking, vision problems, dizziness, or lack of coordination.
Risk factors for TIAs include high blood pressure, high cholesterol, diabetes, smoking, and a history of stroke or heart disease.
Prompt diagnosis and management of TIAs can help prevent a full-blown stroke and reduce the risk of long-term neurological complications.
Explore the latest research on TIAs with PubCompare.ai, an AI-driven platform that helps identify the best protocols and products for your studies, ensuring reproducibility and accuracy.

Most cited protocols related to «Transient Ischemic Attack»

1
MASALA Study Eligibility Criteria
To be eligible for the MASALA study participants had to have (1) South Asian ancestry defined by having at least 3 grandparents born in one of the following countries: India, Pakistan, Bangladesh, Nepal, or Sri Lanka; and (2) age between 40 and 79 years; (3) ability to speak and/or read English, Hindi or Urdu. A pilot study called the Metabolic syndrome and Atherosclerosis in South Asians Living in America (NIH grant #K23 HL080026) had similar eligibility criteria and methods as this larger study. The 150 participants enrolled in the pilot study were eligible to enroll in the current MASALA study.
We used identical exclusion criteria to MESA12 (link) which included having a physician diagnosed heart attack, stroke or transient ischemic attack, heart failure, angina, use of nitroglycerin, or those with a history of cardiovascular procedures such as coronary artery bypass graft surgery, angioplasty, valve replacement, pacemaker or defibrillator implantation, or any surgery on the heart or arteries. Those with current atrial fibrillation or in active treatment for cancer were excluded. Those with life expectancy < 5 years due to a serious medical illness, impaired cognitive ability as judged by the reviewer, plans to move out of the study region in the next 5 years, or those living in a nursing home or on a waiting list were also excluded. Due to CT scanner limitations, those weighing over 300 lbs. were excluded.
Kanaya A.M., Kandula N., Herrington D., Budoff M.J., Hulley S., Vittinghoff E, & Liu K. (2013). Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study: Objectives, Methods, and Cohort Description. Clinical Cardiology, 36(12), 713-720.
Publication 2013
Angina Pectoris Angioplasty Arteries Asian Persons Atherosclerosis Atrial Fibrillation Cardiovascular System CAT SCANNERS X RAY Cerebrovascular Accident Childbirth Cognition Congestive Heart Failure Coronary Artery Bypass Surgery Defibrillators Eligibility Determination Grandparent Infantile Neuroaxonal Dystrophy Malignant Neoplasms Metabolic Syndrome X Myocardial Infarction Nitroglycerin Ovum Implantation Pacemaker, Artificial Cardiac Physicians South Asian People Surgical Procedure, Cardiac Transient Ischemic Attack
2
Predictors of Cardiovascular Events
Data were analyzed using SPSS 13.0 for Windows. Univariate correlations were performed using the nonparametric test (Spearman, Rs). Binary logistic regression was performed to explore possible determinants of cardio- and cerebrovascular events: “coronary heart disease and/or myocardial infarction” and “transient ischemic attack and/or ischemic stroke.” Independent variables showing a P value <0.10 in a univariate analysis were entered in one single step. Receiver-operating characteristic (ROC) analysis was used to assess whether VAI associates with cardio- and cerebrovascular events in comparison to WC, BMI, and TG-to-HDL ratio, considered separately. Difference among C statistics of VAI, BMI, WC, and TG-to-HDL ratio was calculated by Hanley and McNeil's method.
Amato M.C., Giordano C., Galia M., Criscimanna A., Vitabile S., Midiri M, & Galluzzo A. (2010). Visceral Adiposity Index: A reliable indicator of visceral fat function associated with cardiometabolic risk. Diabetes Care, 33(4), 920-922.
Publication 2010
Heart Disease, Coronary Myocardial Infarction Stroke, Ischemic Transient Ischemic Attack
3
Framingham Heart Study: Long-term CVD Outcomes
The Framingham Heart Study started in 1948 with the enrollment of the `original' cohort of 5209 individuals. In 1971, some 5,124 offspring of the original cohort and their spouses were enrolled into the Framingham Offspring Study 30 . Constant monitoring of CVD events and mortality has been carried out and was available through the end of 2007 for this investigation. Attendees of the first Offspring examination were eligible for this investigation if they were at least 20 and below 60 years of age (N=4828), free of CVD (N=4758) and cancer at baseline (N=4723), were not lost to follow-up (N=4680) and had complete risk factor profile yielding a final sample of 4506 individuals (2333 women, mean age 37). All participants gave written informed consent and the study protocol was approved by the Institutional Review Board of the Boston Medical Center.
A detailed physical examination, anthropometry, blood pressure determination, and phlebotomy for vascular risk factors were conducted at each Heart Study examination as described in D'Agostino et al.12 (link) Body mass index (BMI) was calculated as the weight in kilograms divided by the square of height in meters. Antihypertensive medication use was ascertained by the physician examiner at the Heart Study and based on self report. Serum total and high-density lipoprotein (HDL) cholesterol and triglycerides levels were determined using standardized enzymatic methods. Low-density lipoprotein (LDL) cholesterol was calculated using Friedwald's formula31 (link). Cigarette smoking in the year preceding the examination was ascertained by self-report. Diabetes was defined as fasting glucose at or above 126 mg/dL or use of insulin or oral hypoglycemic medications.
Participants were followed for a maximum of 35 years (median 32 years). We focused on a `hard' CVD as the primary outcome of interest and defined it as a composite of hard CHD (coronary death, myocardial infarction) and stroke (fatal and non-fatal). Full CVD defined as in D'Agostino et al.12 (link) (hard CHD plus coronary insufficiency and angina pectoris, stroke plus transient ischemic attack, intermittent claudication and congestive heart failure) was used as a secondary outcome. Medical histories, physical examinations at the study clinic, hospitalization records and communication with personal physicians were all used to obtain information about CVD events on follow up.
Pencina M.J., D'Agostino RB S.r., Larson M.G., Massaro J.M, & Vasan R.S. (2009). Predicting the Thirty-year Risk of Cardiovascular Disease: The Framingham Heart Study. Circulation, 119(24), 3078-3084.
Publication 2009
Angina Pectoris Antihypertensive Agents Blood Vessel Cardiac Death Cerebrovascular Accident Cholesterol Congestive Heart Failure Determination, Blood Pressure Diabetes Mellitus Enzymes Ethics Committees, Research Glucose Heart High Density Lipoprotein Cholesterol Hospitalization Hypoglycemic Agents Index, Body Mass Insulin Intermittent Claudication Low-Density Lipoproteins Malignant Neoplasms Myocardial Infarction Phlebotomy Physical Examination Physicians Serum Transient Ischemic Attack Triglycerides Woman
4
Cerebral Small Vessel Disease Cohort
Cerebral SVD is characterized on neuroimaging by either WML or lacunar infarcts. Symptoms of SVD include acute symptoms, such as transient ischemic attack (TIA) or lacunar syndromes, but also subacute manifestations such as cognitive and motor (gait) disturbances [5 (link)]. As the onset of cerebral SVD is often insidious, clinically heterogeneous, and typically with mild symptoms, it has been suggested that the selection of subjects with cerebral SVD in clinical studies should be based on the more consistent brain imaging features [20 (link)].
Accordingly, in 2006, consecutive individuals referred to the Department of Neurology between October 2002 and November 2006, were selected for possible participation. Inclusion criteria were: (a) age between 50 and 85 years; (b) cerebral SVD on neuroimaging (WML and/or lacunar infarcts). Subsequently, the above mentioned acute and subacute clinical symptoms of SVD were assessed by standardized structured assessments (a questionnaire for TIA and stroke [21 (link)]; for cognition the Cognitive Failures Questionnaire [22 (link)]; for gait the Falls Questionnaire [23 (link)] and the Freezing of Gait Questionnaire [24 (link)]) Subjects who were eligible because of a lacunar syndrome were included only > 6 months after the event to avoid acute effects on the outcomes.
To be able to detect incident dementia and parkinsonism we applied the following exclusion criteria: (a) presence of dementia [25 ] and (b) parkinson(-ism)[26 (link),27 (link)]. In addition patients with (c)intracranial hemorrhage; (d) life expectancy of less than six months; (e) intracranial space occupying lesion; (f) (psychiatric) disease interfering with cognitive testing or follow-up; (g) recent or current use of acetylcholine-esterase inhibitors, neuroleptic agents, L-dopa or dopa-a(nta)gonists; (h) non-SVD related WML (e.g. multiple sclerosis); (i) prominent visual or hearing impairment; (j) language barrier; (k) MRI contraindications or known claustrophobia were excluded.
All participants signed an informed consent form. The Medical Review Ethics Committee region Arnhem-Nijmegen approved the study.
van Norden A.G., de Laat K.F., Gons R.A., van Uden I.W., van Dijk E.J., van Oudheusden L.J., Esselink R.A., Bloem B.R., van Engelen B.G., Zwarts M.J., Tendolkar I., Olde-Rikkert M.G., van der Vlugt M.J., Zwiers M.P., Norris D.G, & de Leeuw F.E. (2011). Causes and consequences of cerebral small vessel disease. The RUN DMC study: a prospective cohort study. Study rationale and protocol. BMC Neurology, 11, 29.
Publication 2011
Acetylcholinesterase Inhibitors Antipsychotic Agents Brain Cerebrovascular Accident Claustrophobia Cognition Dementia Dopa Genetic Heterogeneity Hearing Impairment Infarction, Lacunar Intracranial Hemorrhage Levodopa Mental Disorders Multiple Sclerosis Neurobehavioral Manifestations Parkinsonian Disorders Patients Stroke, Lacunar Transient Ischemic Attack
5
Eligibility Criteria for Carotid Revascularization
Patients were considered to be symptomatic if they had had a transient ischemic attack, amaurosis fugax, or minor nondisabling stroke involving the study carotid artery within 180 days before randomization. Eligibility criteria were stenosis of 50% or more on angiography, 70% or more on ultrasonography, or 70% or more on computed tomographic angiography or magnetic resonance angiography if the stenosis on ultrasonography was 50 to 69%. Eligibility was extended in 2005 to include asymptomatic patients, for whom the criteria were stenosis of 60% or more on angiography, 70% or more on ultrasonography, or 80% or more on computed tomographic angiography or magnetic resonance angiography if the stenosis on ultrasonography was 50 to 69%. Patients were excluded if they had had a previous stroke that was sufficiently severe to confound the assessment of end points or if they had chronic atrial fibrillation, paroxysmal atrial fibrillation that had occurred within the preceding 6 months or that necessitated anticoagulation therapy, myocardial infarction within the previous 30 days, or unstable angina. Additional eligibility criteria were clinical and anatomical suitability, before randomization, for management by means of either of the study revascularization techniques. The full eligibility criteria have been published elsewhere.10 (link)
Brott T.G., Hobson RW I.I., Howard G., Roubin G.S., Clark W.M., Brooks W., Mackey A., Hill M.D., Leimgruber P.P., Sheffet A.J., Howard V.J., Moore W.S., Voeks J.H., Hopkins L.N., Cutlip D.E., Cohen D.J., Popma J.J., Ferguson R.D., Cohen S.N., Blackshear J.L., Silver F.L., Mohr J.P., Lal B.K, & Meschia J.F. (2010). Stenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis. The New England journal of medicine, 363(1), 11-23.
Publication 2010
Amaurosis Fugax Angina, Unstable Angiography Atrial Fibrillation Carotid Arteries Cerebrovascular Accident Computed Tomography Angiography Eligibility Determination Fibrillation, Paroxysmal Atrial Magnetic Resonance Angiography Myocardial Infarction Patients Stenosis Therapeutics Transient Ischemic Attack Ultrasonography

Most recents protocols related to «Transient Ischemic Attack»

1
Physical Activity Equations for Cardiovascular Disease
In this study, we used participants from the previously published “APAC” cohort, a subpopulation of the Kailuan study. The APAC exclusion criteria were previous reported history of stroke, transient ischemic attack, and coronary disease at baseline and absence of neurologic deficits for stroke.
In this study, we further excluded subjects with a previously reported HF or AF. One hundred eighty subjects were excluded because of lack of information or a history of CVD. Finally, 5260 participants were included to develop and validate the sex‐specific physical activity equations (PA equations) (the detailed flow chart can be found in Figure 1).
A baseline examination was conducted at the time of study inclusion. Basic demographic variables such as information of lifestyle and education as well as the past medical history were collected with standardized questionnaires. Body weight and height were measured, and body mass index was calculated as kilograms per meters squared. Information on smoking, drinking, and physical activity were also collected by questionnaires. SBP and DBP were taken at a 5‐min interval, values were measured twice and the mean of the SBPs and DBPs was respectively used.
Physical activity was recorded by using the standardized IPAQ short form under the assistance of professional researchers. The subjects were asked about the time and frequencies of exercises. We then divided the physical activity into low‐intensity activity (<10 min/week), moderate‐activity (10–80 min/week), and high‐intensity activity (>80 min/week). The first follow‐up was conducted between 2011 and 2012. Individuals were followed up every 2 years through face‐to‐face interviews. Subjects with a history of CVD diseases, including MI, chronic ischemic (CI) HF, cerebral hemorrhage (CH), and stroke were excluded.
Zhao J., Yu Y., Zhu X., Xie Y., Ai S., Lehmann H.I., Deng X., Hu F., Li G., Zhou Y, & Xiao J. (2023). Predicting risk on cardiovascular or cerebrovascular disease based on a physical activity cohort: Results from APAC study. MedComm, 4(2), e220.
Publication 2023
Androgen Binding Protein Body Weight Cerebral Hemorrhage Cerebrovascular Accident discoidin-binding polysaccharide Face Heart Disease, Coronary Index, Body Mass Population Group Transient Ischemic Attack
2
Longitudinal Study of Cardiovascular Health
The participants in this study were ≥18 years old and agreed to participate in follow‐up from Jidong community, Caifeidian District, Tangshan city in Hebei province in China.23 The participants were followed up once every other year from 2011 to 2019, a relatively long time span. The Kailuan group is China's large coal mining enterprises, which includes 101,510 employees and retirees. The study cohort of this work was selected from APAC study with 5440 participants. The APAC study is a subpopulation of the Kailuan cohort, which were obtained by adopting stratified random sampling based on age and sex according to the 2010 China National Population Census, the main inclusion criteria for APAC study were no history of stroke, coronary disease and transient ischemic attack.
Zhao J., Yu Y., Zhu X., Xie Y., Ai S., Lehmann H.I., Deng X., Hu F., Li G., Zhou Y, & Xiao J. (2023). Predicting risk on cardiovascular or cerebrovascular disease based on a physical activity cohort: Results from APAC study. MedComm, 4(2), e220.
Publication 2023
Cerebrovascular Accident Heart Disease, Coronary Population Group Transient Ischemic Attack
3
Cognitive Function Assessment in Transylvania
A cross-sectional quantitative survey was performed in Harghita County (Transylvania, Romania). The patients were recruited from three randomly chosen settlements (Joseni, Ciumani and Lăzarea) with the help of general practitioners of these villages. All of the patients were informed about the purpose of the study and the voluntary nature of the participation. Participants gave written informed consent before taking part in the study. The protocol of the study was approved by the Ethics Committee of the University of Babeș-Bolyai (RO) and by the Code of Deontology for the professions of psychologists, elaborated by the Romanian College of Psychologists. Cognitive functions were assessed independently for each participant by accredited clinical psychologists. Inclusion criteria were: 1) ages between 35 and 65 years [8 (link), 9 ], 2) diagnosed with T2D or hypertension or both (comorbid T2D and hypertension) according to the standards of the American Diabetes Association (2020) [10 (link)] and according to the standards of the American College of Cardiology and American Heart Association guidelines [11 ], respectively, and 3) diabetes and/or hypertension duration at least 5 years. From this study, patients were excluded with 1) any medical illnesses other than T2D, dyslipidemia, hypertension and obesity, 2) a history of hypoglycemic coma or complications of diabetes, 3) primary neurological condition as history of transient ischemic attacks, cerebrovascular stroke or epilepsy or psychiatric disease, 4) previous serious head injury, 5) any sensory or motor disorder that would preclude psychological testing (including blindness), 6) regular treatment with any medications known to have psychoactive effect, and 7) drug or alcohol abuse. The control group was made up of people who applied at the invitation of the municipality's management and did not have a chronic illness. Their health status was checked at the health clinic of the municipality.
The patients were divided into three groups: a group with T2D, a group with hypertension and a group with both diseases. The control group was specifically recruited from the settlement where the patients were registered.
Kálcza Jánosi K, & Lukács A. (2023). Independent and interactive effect of type 2 diabetes and hypertension on memory functions in middle aged adults. BMC Endocrine Disorders, 23, 59.
Publication 2023
Abuse, Alcohol Blindness Cardiovascular System Cerebrovascular Accident Cognition Comatose Complications of Diabetes Mellitus Craniocerebral Trauma Diabetes Mellitus Disease, Chronic Dyslipidemias Epilepsy Ethics Committees General Practitioners High Blood Pressures Hypoglycemic Agents Mental Disorders Motor Disorders Nervous System Disorder Obesity Patients Pharmaceutical Preparations Pharmacotherapy Transient Ischemic Attack
4
Carotid Endarterectomy Plaque Analysis
A total of 33 plaques were obtained from 31 patients (21 Males/10 Females) undergoing endarterectomy in the Department of Vascular Surgery and Transplantation, Rambam Medical Centre, using standard surgical techniques (15 (link)). Surgery was performed if carotid stenosis was 50% or more in clinically symptomatic patients, in those who had either ipsilateral cerebrovascular event (CVA) or transient ischemic attack (TIA) or amaurosis fugax in the last 180 days, and in clinically asymptomatic patients if the stenosis was 70% or higher. Asymptomatic patients included those with carotid artery stenosis without a history of ischemic stroke, TIA or other neurologic symptoms referable to the carotid arteries as defined by NASCET-North American Symptomatic carotid Endarterectomy Trial (16 (link)). Demographic data, comorbidities, risk factors, medications, and blood chemistry were recorded. The protocol was approved by The Local Humans Rights Committee of RAMBAM Medical Center (RMB-0175-14), according to the declaration of Helsinki, and all patients signed an informed consent form.
Lavie L., Si-on E, & Hoffman A. (2023). Giant phagocytes (Gφ) and neutrophil-macrophage hybrids in human carotid atherosclerotic plaques – An activated phenotype. Frontiers in Immunology, 14, 1101569.
Publication 2023
Amaurosis Fugax Blood Chemical Analysis Carotid Arteries Carotid Endarterectomy Carotid Stenosis Endarterectomy Females Males Neurologic Symptoms North American People Operative Surgical Procedures Patients Pharmaceutical Preparations Senile Plaques Stenosis Stroke, Ischemic Transient Ischemic Attack Transplantation Vascular Surgical Procedures
5
Acute Stroke Patients Data Collection
186 acute stroke patients hospitalized at the Department of Neurology, Xiangya Hospital of Central South University were recruited from July 2019 to February 2021. Inclusion criteria were: (1) age from 18-75 years, (2) diagnosed with acute stroke by brain magnetic resonance imaging or computerized tomography imaging within 2 weeks since onset, (3) ability to complete all necessary evaluations. The exclusion criteria were performed as described previously (20 (link)). Written informed consents were signed from all patients, as approved by Medical Ethics Committee of the Xiangya Hospital of Central South University. We collected the information on demographic data (age, gender and years of education), vascular risk factors (hypertension, diabetes, heart disease, hyperlipidemia, current smoking and drinking), history of stroke, transient ischemic attack (TIA), intravenous thrombolysis and/or endovascular treatment, type of stroke (ischemic, hemorrhagic or subtypes according to the Trial of Org 10,172 in Acute Stroke Treatment [TOAST] classification) (21 (link)), stroke hemisphere (left, right or bilateral) and location (anterior, posterior or both), National Institute of Health Stroke Scale (NIHSS) score and Mini-Mental State Examination (MMSE) score, time from stroke onset to the blood sample collection, the complete blood counts (leukocyte, neutrophil, monocyte, lymphocyte and platelet counts) from the first blood routine results, pulmonary and/or urinary tract infection, and antibiotic. And the assessment of depressive symptoms and grouping of patients have been described in our previous investigation (20 (link)).
Chen H., Huang X., Zeng C., Sun D., Liu F., Zhang J., Liao Q., Luo S., Xu W., Xiao Y., Zeng D., Song M, & Tian F. (2023). The role of indoleamine 2,3-dioxygenase 1 in early-onset post-stroke depression. Frontiers in Immunology, 14, 1125634.
Publication 2023
Acute Cerebrovascular Accidents Antibiotics BLOOD Blood Vessel Brain Cerebrovascular Accident Complete Blood Count Diabetes Mellitus Ethics Committees, Clinical Fibrinolytic Agents Gender Heart Diseases Hemorrhage High Blood Pressures Hyperlipidemia Leukocytes Lung Lymphocyte Mini Mental State Examination Monocytes Neutrophil Patients Platelet Counts, Blood Specimen Collections, Blood Symptom Assessment Transient Ischemic Attack Urinary Tract Infection X-Ray Computed Tomography

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More about "Transient Ischemic Attack"

Transient Ischemic Attack (TIA), also known as a mini-stroke, is a brief episode of neurological dysfunction caused by a temporary reduction in blood flow to the brain or retina, without permanent tissue damage.
TIAs are often considered a warning sign of a potential future stroke and require prompt medical attention.
Symptoms of a TIA may include sudden numbness or weakness, difficulty speaking, vision problems, dizziness, or lack of coordination.
Risk factors for TIAs include high blood pressure, high cholesterol, diabetes, smoking, and a history of stroke or heart disease.
Prompt diagnosis and management of TIAs is crucial to help prevent a full-blown stroke and reduce the risk of long-term neurological complications.
The latest research on TIAs can be explored using PubCompare.ai, an AI-driven platform that helps identify the best protocols and products for your studies, ensuring reproducibility and accuracy.
Utilizing tools like SAS version 9.4, ADVIA Centaur XP, SAS 9.4, SAS software, SAS v9.4, R version 3.6.1, Sphygmomanometer, STATA version 10, and SPSS 20.0 can aid in the analysis and understanding of TIA-related data.
By incorporating these resources, researchers can experiance reproducibility and accuracy in their studies on Transient Ischemic Attack.