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Trichiasis

Trichiasis: A medical condition characterized by the abnormal inward turning of the eyelashes, which can lead to irritation, inflammation, and damage to the cornea.
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Most cited protocols related to «Trichiasis»

1
Korean Guidelines for Dry Eye Disease Diagnosis and Management
The Korean Corneal Disease Study Group (KCDSG) is an independent, non-profit, academic society whose members comprise the most active corneal subspecialists in Korea. In 2009, the initial survey on the definition, diagnosis, severity grading, and management of dry eye disease was conducted among the members of the KCDSG. In this survey, we found that 78.8% of KCDSG members use the DEWS classification [3 (link)] as diagnostic guidelines of dry eye disease, while 21.2% use guidelines proposed by the DTS group [2 (link)]. KCDSG members also responded that they consider subjective symptoms, tear film breakup time (TBUT), and signs of ocular surface inflammation of more diagnostic value than other parameters. Based on the results of this survey, along with a review of the contemporary literature with regard to definition, classification, and treatment recommendations for dry eye, the subcommittees held face-to-face meetings to reach a consensus on the issues related to the definition, diagnosis, severity grading, and treatment recommendations for dry eye disease. New guidelines for the diagnosis and management of dry eye disease were adopted as shown in Tables 1 and 2. These guidelines were based on DEWS guidelines and modified to simplify the grading scheme so that they could be used more easily in clinical practice.
Dry eye disease was defined as "a disease of the ocular surface that is associated with tear film abnormalities." We agreed that a patient should be diagnosed with dry eye disease when he or she has at least one symptom and one objective sign. In the diagnosis guidelines, dry eye symptoms included ocular symptoms (such as dryness, discomfort, foreign body sensation, and pain) and visual symptoms (such as blurring or vision fluctuation). Ocular surface staining score by the Oxford system [9 (link)], TBUT, and Schirmer-1 test score were used as objective signs for diagnosing dry eye disease. Conjunctival injection, lid problems such as blepharitis, trichiasis, keratinization, or symblepharon, and tear film abnormalities such as debris, decreased tear meniscus, and mucus clumping, were considered signs of ocular surface inflammation, but these findings were not considered during the grading of disease severity. The severity level of the disease was determined when both designated symptoms and signs were present at a certain level. If there was a discrepancy between the patients' symptoms and signs, the severity level was determined according to the severity level of the objective signs. When several objective signs were present at different levels, the severity level of the disease was determined following ocular surface staining. In addition, we introduced a provisional category of "dry eye suspect," which is not listed on the grading scheme. The patient was diagnosed with suspected dry eye when he or she had only dry eye symptoms without any objective signs. This was to evaluate the distribution of disease severity at the initial visit, and the treatment recommendation did not include the category of "dry eye suspect."
Detailed treatment options for each particular level from level I to level IV were recommended as shown in Table 2.
Hyon J.Y., Kim H.M., Lee D., Chung E.S., Song J.S., Choi C.Y, & Lee J. (2014). Korean Guidelines for the Diagnosis and Management of Dry Eye: Development and Validation of Clinical Efficacy. Korean Journal of Ophthalmology : KJO, 28(3), 197-206.
Publication 2014
ARID1A protein, human Blepharitis Chryseobacterium nakagawai Congenital Abnormality Conjunctiva Cornea Corneal Diseases Disease Management Dry Eye Dry Eye Syndromes Face Foreign Bodies Inflammation Koreans Meniscus Mucus Pain Patients Signs and Symptoms Tears Trichiasis Vision
2
Nested Case-Control Study of Trichiasis
This case-control study was nested within a clinical trial of two alternative surgical treatments for trichiasis. From the 1000 trichiasis cases recruited into the trial, every fifth consecutive case was also enrolled into this economic poverty study and matched to a non-trichiasis control. This approach was chosen for logistical and methodological reasons, in order to identify and collect data from controls within the shortest possible time period following case recruitment. Cases were defined as individuals with one or more eyelashes touching the eyeball or with evidence of epilation in either or both eyes in association with tarsal conjunctival scarring. People with trichiasis of other causes, recurrent trichiasis and those under 18 years were excluded. Trichiasis cases were identified mainly through community-based screening. Trichiasis screeners and counsellors (Eye Ambassadors) visited every household in their target village, identified and referred trichiasis cases to health facilities where surgical services were provided. Some individuals self-presented or were referred by local health workers. Recruitment was mainly from three districts of West Gojam Zone, Amhara Region, Ethiopia between February and May 2014. This area has one of the highest burdens of trachoma worldwide [21 (link)].
Controls were individuals without clinical evidence or a history of trichiasis (including surgery and epilation), and who came from households without a family member with trichiasis or a history of trichiasis, as we wanted to measure household level relative poverty, which requires comparison of trichiasis case households with households without trichiasis cases. One control was individually matched to each trichiasis case by location, sex and age (+/- two years). The research team visited the sub-village (30–50 households) of the trichiasis case requiring a matched control. A list of all potentially eligible people living in the sub-village of was compiled with the help of the sub-village administrator. One person was randomly selected from this list using a lottery method, given details of the study and invited to participate if eligible. If a selected individual refused or was ineligible, another was randomly selected from the list. When eligible controls were not identified within the sub-village of the case, recruitment was done in the nearest neighbouring sub-village, using the same procedures.
Habtamu E., Wondie T., Aweke S., Tadesse Z., Zerihun M., Zewdie Z., Callahan K., Emerson P.M., Kuper H., Bailey R.L., Mabey D.C., Rajak S.N., Polack S., Weiss H.A, & Burton M.J. (2015). Trachoma and Relative Poverty: A Case-Control Study. PLoS Neglected Tropical Diseases, 9(11), e0004228.
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Publication 2015
Administrators Conjunctiva Depilation Eyelashes Family Member Health Personnel Households Operative Surgical Procedures Trachoma Trichiasis
3
Longitudinal Trachoma Grading and Sampling
Study participants were assessed at baseline, 6, 12, 18 and 24 months. They were examined for clinical signs of trachoma using 2.5x binocular loupes. On each occasion high resolution digital photographs were taken of the upper tarsal conjunctiva, for subsequent grading and comparison by a single ophthalmologist experienced in trachoma grading. Features were graded using the detailed WHO trachoma grading system with previously described modifications [6 (link),8 (link),11 ]. The tarsal conjunctival grading system is described in S1 Table [8 (link)]. Significant conjunctival inflammation was defined as the presence of papillary inflammation grades P2 or P3 of the detailed WHO Trachoma Grading System [11 ]. In both studies only one eye per person was included in the analysis for scarring progression and for the collection of conjunctival swab samples. In the Ethiopian study for individuals with bilateral trichiasis, the clinical trial study eye was randomly designated for inclusion as the outcome of epilation or surgery could be influenced by the laterality, although both eyes were treated. In the Tanzanian study the left eye was designated the study eye for all participants, for protocol simplicity.
On each occasion the ocular surface was anaesthetised with preservative-free proxymetacaine 0.5% eye drops (Minims, Chauvin Pharmaceuticals). Two conjunctival swab samples were collected from the upper tarsal conjunctival surface by making four horizontal passes across the conjunctival surface with a quarter turn between each pass (Dacron polyester-tipped swab: Hardwood Products Company). The first swab was collected for RNA isolation and placed directly into a tube containing 0.3ml of RNAlater (Life Technologies). The second swab was collected for a DNA primed C. trachomatis PCR and was placed in a dry tube. Samples were kept on ice packs until frozen later the same day at—20°C. Long-term storage was at -80°C. The Ethiopian samples were transferred to Tanzania on dry ice for analysis.
Burton M.J., Rajak S.N., Hu V.H., Ramadhani A., Habtamu E., Massae P., Tadesse Z., Callahan K., Emerson P.M., Khaw P.T., Jeffries D., Mabey D.C., Bailey R.L., Weiss H.A, & Holland M.J. (2015). Pathogenesis of Progressive Scarring Trachoma in Ethiopia and Tanzania and Its Implications for Disease Control: Two Cohort Studies. PLoS Neglected Tropical Diseases, 9(5), e0003763.
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Publication 2015
Chlamydia trachomatis Conjunctiva Conjunctivitis Dacron Depilation Disease Progression Dry Ice Eye Drops Fingers Freezing Functional Laterality Inflammation isolation Operative Surgical Procedures Ophthalmologists Pharmaceutical Preparations Pharmaceutical Preservatives Polyesters proparacaine Specimen Collection Trachoma Trichiasis Vision
4
Evaluating Trachoma Surgery Outcomes
This analysis relies on data from the Partnership for Rapid Elimination of Trachoma (PRET) Surgery trial. PRET is a randomized, masked clinical trial comparing outcomes following BLTR surgery using either standard instrumentation or the TT clamp [18] (link). Sutures were removed two weeks post-operatively. Six weeks, 12 months and 24 months after surgery, participants were examined for trichiasis recurrence, ECAs, and pyogenic granuloma formation. Field grades were recorded for each outcome at each visit. Photographs were taken pre-operatively, immediately post-operatively, and at each follow-up visit. For the current analysis, photographs from the six-week visit were utilized.
Photographs were taken in a standardized fashion. All follow up photographs were taken with the patient seated and the camera lens nine inches from the patient's superior orbital rim. Patients were asked to keep their head facing forward, but to look up as high as they could so that the upper eyelid margin could be seen. At the start of the PRET trial, one of the senior photograph graders (SLM) trained the field grader on classification of ECAs. At that time, we classified ECAs as mild or severe. However, during the course of developing the grading system, after the completion of the six-week period and the start of the one year follow-up period, we determined we could more finely delineate severity categories. In order to be able to directly compare the 6-week field and photograph grades, photographs graded as moderate or severe were combined into a single category called severe when comparing the field and photograph grades.
Gower E.W., West S.K., Cassard S.D., Munoz B.E., Harding J.C, & Merbs S.L. (2012). Definitions and Standardization of a New Grading Scheme for Eyelid Contour Abnormalities after Trichiasis Surgery. PLoS Neglected Tropical Diseases, 6(6), e1713.
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Publication 2012
Eyelids Head Lens, Crystalline Operative Surgical Procedures Patients Pyogenic Granuloma Recurrence Sutures Trachoma Trichiasis Vision
5
Trachoma Screening and Mass Azithromycin Treatment
We conducted the study in Kahe Mpya subvillage, Rombo District, Tanzania. This community has been described previously. 15 (link) In July 2000, we examined each consenting resident for trachoma, using the simplified system of the World Health Organization. 16 (link) This grading system includes five signs: trachomatous inflammation–follicular, defined as five or more follicles at least 0.5 mm in diameter in the central plate; trachomatous inflammation–intense, defined as pronounced inflammatory thickening of the upper tarsal conjunctiva obscuring at least half the normal deep tarsal vessels; trachomatous scarring; trachomatous trichiasis; and corneal opacity. We then swabbed the tarsal conjunctiva of each subject’s right eye, using a highly standardized swabbing technique. 15 (link) Every nonpregnant resident 12 months of age or older was then offered one directly observed oral dose of 20 mg of azithromycin per kilogram of body weight (maximum, 1 g). Children younger than 12 months of age and pregnant women were not given azithromycin, but instead were offered two tubes of 1 percent tetracycline, with instructions to apply the ointment twice daily for 6 weeks. Azithromycin was donated by Pfizer through the International Trachoma Initiative, Dar es Salaam, Tanzania. Neither of these organizations had any role in the study design, data analysis, manuscript preparation, or the publication decision. Tetracycline was obtained on the open market. All treatment was provided free to subjects.
Solomon A.W., Holland M.J., Alexander N.D., Massae P.A., Aguirre A., Natividad-Sancho A., Molina S., Safari S., Shao J.F., Courtright P., Peeling R.W., West S.K., Bailey R.L., Foster A, & Mabey D.C. (2004). Mass Treatment with Single-Dose Azithromycin for Trachoma. The New England journal of medicine, 351(19), 1962-1971.
Publication 2004
Azithromycin Blood Vessel Body Weight Child Conjunctiva, Bulbar Conjunctivitis Hair Follicle Inflammation Ointments Pregnant Women Tetracycline Trachoma Trichiasis Youth

Most recents protocols related to «Trichiasis»

1
Epidemiology of Epiphora: Comprehensive Evaluation
A retrospective and chart review was conducted on patients with epiphora, who were referred to the oculoplastic surgery clinic of the tertiary ophthalmology hospital between January 2014 and July 2021. Due to the retrospective nature of the study, an informed consent form was not obtained from the patients. The study was planned in accordance with the Declaration of Helsinki and ethics committee approval has been obtained (March 09, 2022, E22–922).
This study included patients over the age of 18 who complained of epiphora and was followed up in the oculoplastic surgery clinic for at least 6 months. Patients with epiphora due to congenital nasolacrimal duct obstruction (NLDO), tumor-induced NLDO, and trauma-related eyelid or canaliculi injury were not included in this study.
Data regarding age, gender, etiology, duration of symptoms, and follow-up periods of all patients were retrospectively recorded. In our clinic, a routine approach is applied to determine all etiological causes for the evaluation of epiphora. For every tearing patient referred to oculoplastic sugery clinic, lacrimal irrigation is performed to analyze for functional/anatomical obstructions of the punctum, canaliculi, lacrimal system, and Schirmer test, tear break-up time, corneal and conjunctival staining is performed to evaluate for dry eye. Furthermore, we assessed eyelid diseases such as entropion, ectropion, and trichiasis. These patients were categorized into lacrimal system diseases (e.g., punctal stenosis, canaliculitis, canaliculi obstruction, and NLDO, eyelid malpositions (e.g., entropion and ectropion), and hypersecretory causes (e.g., dry eye, superficial corneal diseases, allergy, and inflammation).
Statistiscal analyses were performed with Statistical Package for the Social Sciences (SPSS Inc., Chicago, Illionis, USA) version 22.0. Continuous variables were presented as the mean±standart deviation, and quantitative variables were presented as frequency (%). For categorical variables, the Chi-square test was used. The mean age, follow-up period, and symptom duration of more than two groups were compared using analysis of variance (ANOVA), Independent-t test was used to compare between two groups. P<0.05 was considered statistically significant.
Ceylanoglu K.S., Acar A, & Sen E. (2023). Overview of Epiphora Referred to Oculoplastic Surgery Clinic in Adults. Beyoglu Eye Journal, 8(1), 45-49.
Publication 2023
Canaliculitis Conjunctiva Cornea Corneal Diseases Dry Eye Syndromes Ectropion Entropion Ethics Committees Eyelid Diseases Eyelids Gender Hypersensitivity Inflammation Injuries Lacrimal Apparatus Neoplasms Operative Surgical Procedures Patients Stenosis Tears Trichiasis Wounds and Injuries
2
Comparative Study of Diabetic Eye Health
A comparative cross-sectional hospital-based study was conducted in a group of 122 consecutive patients with DM and a group of 119 patients with no DM, age-matched by group, who attended the ophthalmology clinic at two tertiary teaching hospitals in Jordan (Jordan University Hospital and King Abdullah University Hospital). All patients were Jordanians of Arab ethnicity.
In the DM group, DM was diagnosed if patients were currently treated with oral hypoglycemic agents, with or without insulin, and if they fulfilled the American Diabetic Association (ADA) Guidelines diagnostic criteria [14 (link)]. In the non-DM group, all patients had glycosylated hemoglobin (HbA1c) <5.8%. Those with a history of ocular surgery involving the ocular surface or nasolacrimal apparatus, eyelid abnormalities (e.g., entropion and trichiasis), acute conjunctivitis, recent use of topical ophthalmic medication (e.g., steroids), and history of wearing contact lenses were excluded.
The study was approved by the Ethics Committee for Medical Research at the Jordan University Hospital and the University of Jordan. It adhered to the tenets of the Declaration of Helsinki. Informed consent for participation was obtained from all participants.
Jammal H.M., Abu-Ameerh M., Hiasat J.G., Issa S, & Al Bdour M. (2023). The Relationship between Pinguecula and Diabetes Mellitus: A Comparative Cross-Sectional Study. Journal of Ophthalmology, 2023, 9060495.
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Publication 2023
Age Groups Arabs Congenital Abnormality Conjunctivitis Contact Lenses Diagnosis Entropion Ethics Committees Eyelids Hemoglobin, Glycosylated Hypoglycemic Agents Insulin Lacrimal Apparatus Patients Pharmaceutical Preparations Steroids Trichiasis Vision
3
Trachoma Epidemiology in Ceará, Brazil
We conducted an ecological study based on epidemiological data on trachoma in the state of Ceará (Figure 1), reported in the Information System on Notifiable Diseases (SINAN) by the Secretary of Health of the State of Ceará. This database contains the records of surveys conducted in municipalities in the state of Ceará. Information was collected from individuals who were examined and diagnosed with trachoma upon external eye examinations. Data from 2007 to 2021 were used in this study. Beginning in 2007, the results of trachoma investigations were made available in SINAN by the Secretary of Health of the state of Ceará.
Health regions of the state of Ceará, Brazil.During the study period (2007-2021), school and household surveys were developed concomitantly. Between 2011 and 2013, household surveys predominated, with a proposed sampling of 80% of households. School surveys continued in the period 2013-2017 as part of the Ministry of Health’s “National Campaign on Leprosy, Worms, Trachoma, and Schistosomiasis”. During this period, external eye examinations were conducted among public school students aged 5-14. From 2017, following the "Panel of Strategic Health Surveillance Indicators of the State of Ceará”, the proposed sample was 50% or more of students aged 1-9 in the public elementary school network of the municipalities considered a priority that was part of each health region. The contents of schoolchildren with trachoma were examined through household surveys.
Our analysis was based on calculating absolute and relative frequencies using the percentage of positivity. To this end, we counted the number of positive cases of trachoma, divided it by the total number of individuals examined, and multiplied this by 100. The operational parameters proposed as a reference by the Brazilian Ministry of Health consider variations in endemicity levels, with values <5.0%, 5.0-9.9%, and ≥10.0%.
Demographic and clinic-epidemiological patterns were characterized according to the percentage of positivity for trachoma and represented based on the levels of endemicity in the period 2007-2021, according to the following variables: health regions of the state of Ceará (Figure 1), using the administrative management model adopted by the Health Department of the state of Ceará, with subdivisions and respective number of municipalities (Litoral Leste/Jaguaribe [20], Cariri [45], Sertão Central [20], Norte [55], and Fortaleza [44]); sex (male and female); age group (0-4, 5-9, 10-14, and ≥15 years); area of residence (urban, peri-urban or rural); clinical forms, according to the case definition for the disease based on the active forms (trachomatous inflammation follicular [TF], presence of ≥ 5 follicles > 0.5 mm in the upper tarsal conjunctiva of the eye; trachomatous inflammation intense [TI], inflammatory thickening of the upper tarsal conjunctiva, not allowing visualization of > 50% of the deep tarsal vessels); and sequelae forms (trachomatous scarring [TS], presence of scarring of the upper tarsal conjunctiva; trachomatous trichiasis [TT], presence of at least one of the lashes rubbing the eyeball or evidence of recent epilation of lashes on the upper eyelid; and corneal opacity [CO], opacity obscuring the pupillary margin)4.
The organization and management of the database were performed using the statistical program Stata 11.2 (Stata Statistical Software, StataCorp LP, College Station, TX, USA) through the construction of tables and graphs.
The temporal patterns of positivity for the disease were analyzed considering the variation in endemicity levels in the health regions of the State of Ceará for the entire period of 2007-2021. The data were exported and joined to the shapefiles of the municipalities of the state of Ceará, according to the standards of the Brazilian Institute of Geography and Statistics, using the software QGIS version 2.18.6 (licensed under the General Public License [GNU], available at https://qgis.org/pt_BR/site/. We constructed thematic maps by verifying the spatial patterns of endemicity in the pre- coronavirus disease (COVID-19) pandemic period (2007-2010, 2011-2014, 2015-2019) and during the COVID-19 pandemic (2020-2021).
This study was approved by the Ethics Committee of the Hospital São José de Doenças Infecciosas (HSJ) of the State of Ceará (opinion number 5.132.182).
Maciel A.M., Ramos AN J.r., Gomes V.D., Ferreira A.F., de Almeida N.M., Gómez D.V., Favacho J.D., Maciel M.M., Delerino A.L, & Pires RD N.e.t.o. (2023). Epidemiology and control of trachoma in the state of Ceará, Northeast Brazil, 2007-2021. Revista da Sociedade Brasileira de Medicina Tropical, 56, e0207-2022.
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Publication 2023
Age Groups Blood Vessel Conjunctiva Conjunctiva, Bulbar Conjunctivitis Coronavirus Infections Depilation Ethics Committees, Clinical Eye Eyelids Hair Follicle Health Campaigns Helminthiasis Households Inflammation Leprosy Males Menstruation Disturbances Microtubule-Associated Proteins Pandemics Physical Examination Pupil Schistosomiasis sequels Student Trachoma Trichiasis Woman
4
Argon Laser Photocoagulation for Conjunctival Chalasis
We reviewed the medical charts of 25 eyes from 19 patients who were diagnosed with CCh and received modified laser photocoagulation treatment at the Konkuk University Hospital between March 2012 and August 2019. The study followed the Declaration of Helsinki principles and was approved by the Institutional Review Board/Ethics Committee of the Konkuk University Medical Center (IRB number 2022-03-059). Informed consent was obtained from each patient before undergoing the laser procedure.
All patients had CCh-related symptoms such as epiphora, ocular irritation, or discomfort. We recommended argon laser treatment if a patient was dissatisfied with medical treatments such as artificial tears, ointments, antihistamine drops, or anti-inflammatory drops. All patients underwent a complete ophthalmic examination including visual acuity measurements, external eye examination, intraocular pressure measurements, and slit-lamp anterior segment examination to evaluate their ocular surface and CCh grade. Patients were excluded if they had a history of trichiasis, entropion, blepharitis, pterygium, pinguecula, keratoconjunctivitis sicca, Sjögren’s syndrome, prior history of ocular conjunctiva surgery, and several other systemic conditions relating to eye disease such as Graves’ diseases.
CCh grades were determined as lid-parallel conjunctival folds under slit-lamp examination, as previously described.[13 (link),15 (link)] Patients were classified as grade 0 (no persistent fold), 1 (single, small fold), 2 (more than 2 folds there were below the tear meniscus), or 3 (multiple folds that were above the tear meniscus). Patients were asked if their symptoms improved and if they thought the surgery was successful at the last follow-up. We defined surgical success as improvement in CCh grade without recurrence over 6 months and when a patient expressed subjective improvement and satisfaction during an office examination.
The overall procedure is depicted in Fig. 1 and shown in Video S1, Supplemental Digital Content, http://links.lww.com/MD/I308. The eye was initially anesthetized using 0.5% topical proparacaine. While their lower eyelid was pulled down, the patient was asked to look upward until the CCh was in the center of the slit-lamp microscope’s field of view, and a dark purple skin marker was used to apply the ink directly to the redundant conjunctival surface (Fig. 1), which increased energy absorption at the conjunctiva by the argon laser, thereby reducing the required laser power. The beam was aimed at the outer inferior conjunctiva at least 2 mm from the limbus to avoid thermal damage. This low-energy argon laser photocoagulation method was applied a mean of 80 times with a 532 nm green argon laser (VISULAS 532s, Carl Zeiss Meditec, Jena, Germany) using a 500 μm spot size for 0.5 seconds at 250 to 400 mW. The power of the laser was increased by 50 mW starting from the baseline of 250 mW until the conjunctiva became blanched shrunken and had small cavitations in response to the laser. Coagulation was considered adequate when the conjunctiva became blanched and shrunken and had small cavitations. After the treatment, 0.3% gatifloxacin and 0.1% fluorometholone were topically applied 4 times daily for a week. All these procedures were performed by H.J.S. Patients were screened at 1 week, 1 month, 3 months, and 6 months after the procedure. After the 6-month follow-up, patients were instructed to visit if they had any discomfort. Only patients who visited the hospital for more than 6 months after the procedure were included in this study.
All statistical analyses were performed using SPSS version 20.0. Paired t tests were used to analyze the pre- and postoperative CCh grades of the patients.
Han J., Lee S.H., Choi C.Y, & Shin H.J. (2023). Treatment outcomes of modified argon laser photocoagulation for conjunctivochalasis. Medicine, 102(2), e32633.
Publication 2023
Anti-Inflammatory Agents Argon Ion Lasers Blepharitis Coagulation, Blood Conjunctiva Conjunctiva, Bulbar Entropion Epiphora Ethics Committees Eye Disorders Eyelids Fluorometholone Gatifloxacin Graves Disease Histamine H1 Antagonists Hospital Administration Keratoconjunctivitis Sicca Laceration Light Coagulation Lubricant Eye Drops Meniscus Neoplasm Metastasis Ointments Operative Surgical Procedures Patients Pinguecula proparacaine Pterygium Of Conjunctiva And Cornea Recurrence Satisfaction Sjogren's Syndrome Skin Slit Lamp Examination Tonometry Trichiasis Vision Visual Acuity
5
Comprehensive Evaluation of Meibomian Gland Dysfunction
This study was conducted in accordance with the tenets of the Declaration of Helsinki and was approved by the Institutional Review Board (IRB) of the Eye, Ear, Nose, and Throat (EENT) Hospital of Fudan University. The clinical trial was registered in the Chinese Clinical Trial Registry on June 2019. The registration number is ChiCTR-1900023732. Fifty patients who experienced MGD were recruited from the EENT hospital from September 2019 to December 2019. According to consensus of The International Workshop on Meibomian Gland Dysfunction, MGD was confirmed by meibomian gland function examination by the same ophthalmology 1 (link), 10 (link).
The inclusion criteria for MGD based on DEWS II: OSDI score > 12.5 points, FBUT < 10 s; the presence of lid margin abnormalities, orifice abnormalities, and meibum abnormalities 1 (link), 10 (link). These MGD patients aged above 18 years old, who voluntarily participated in the experiment. Subjects with certain ocular diseases (acute ocular inflammation, obvious scar or keratinization in palpebral margin) or receiving physiotherapy for blepharitis (intense pulsed light, baby shampoo, and demodex blepharitis treatments) in the last 3 months may confound the study results; thus, they were excluded from the study. Subjects were also excluded if they had a related ocular surgery, including cataract surgery, trichiasis surgery, lachrymal duct obstruction, or refractive surgery in the past 3 months. After the procedure and potential consequences of the study were explained elaborately, informed consent was obtained from all subjects before the experiment.
At every follow-up, visual acuity, intraocular pressure and anterior segment were observed so as to ensure the safety of treatment. Subsequently, all participants received ocular surface examination including OSDI, meibomian gland expressibility (MGE), meibomian gland quality (MQ), lid margin, meibograde, fluorescein tear film break-up time (FBUT), non-invasive tear break-up time (NIKBUT), corneal fluorescein staining (CFS), Schirmer I test (SIT), tear meniscus height (TMH), lipid layer thickness (LLT) and incomplete blink rate (%).
Liu W., Lin T, & Gong L. (2023). Meibomian gland dysfunction patients benefit in ocular parameters and tear chemokines after thermal pulsation treatment. International Journal of Medical Sciences, 20(1), 11-22.
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Publication 2023
Blepharitis Blinking Cataract Extraction Chinese Cicatrix Congenital Abnormality Consensus Workshops Cornea Ethics Committees, Research Eyelids Infant Inflammation Light Lipids Meibomian Gland Dysfunction Meibomian Glands Meibum Meniscus Nose Operative Surgical Procedures Patients Pharynx Safety Surgeries, Refractive Tears Therapy, Physical Tonometry, Ocular Trichiasis Vision Visual Acuity

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Stata V.15 is a comprehensive statistical software package that provides a wide range of data analysis and management tools. It offers features for data manipulation, statistical modeling, graphics, and programming. Stata V.15 is designed to handle complex data structures and provide advanced analytical capabilities for researchers, analysts, and professionals across various fields.

More about "Trichiasis"

Trichiasis is a medical condition characterized by the abnormal inward turning of the eyelashes, which can lead to irritation, inflammation, and damage to the cornea.
This eye disorder, also known as entropion, can cause discomfort, redness, and even vision problems if left untreated.
The condition is often associated with various underlying causes, such as aging, eye injuries, eye surgeries, or certain medical conditions like blepharitis, trachoma, or ocular cicatricial pemphigoid.
Early detection and proper management are crucial to prevent complications and preserve eye health.
Researchers and clinicians can leverage advanced tools like PubCompare.ai's AI-powered platform to streamline Trichiasis research.
This innovative solution provides easy access to relevant protocols from literature, pre-prints, and patents, and utilizes AI comparisons to identify the best approaches for Trichiasis studies.
By enhancing reproducibility and accuracy, PubCompare.ai can help optimize the research process and lead to more effective treatment strategies.
In addition to PubCompare.ai, researchers may also find value in utilizing statistical software like Stata 10.0, Stata 15, SPSS Statistics version 22, Stata 12.0, Stata 13, SPSS version 20.0, and SAS 9.4 to analyze data and inform their Trichiasis studies.
The use of diagnostic tools, such as the Slit-lamp biomicroscope, can also provide valuable insights into the condition.
Furthermore, advancements in mobile technology, like the Galaxy S8, can aid in the monitoring and management of Trichiasis, especially for patients in remote or underserved areas.
By leveraging these technological solutions, researchers and clinicians can enhance the understanding, prevention, and treatment of this eye disorder, ultimately improving the quality of life for those affected by Trichiasis.