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> Disorders > Neoplastic Process > Intraocular Lymphoma

Intraocular Lymphoma

Intraocular Lymphoma is a rare and aggressive type of eye cancer that occurs when lymphocytes (a type of white blood cell) grow uncontrollably within the eye.
This condition can lead to vision problems, eye pain, and other serious complications if left untreated.
It is important for researchers to identify the most effective treatment approaches and products to ensure accurate diagnosis and effective management of Intraocular Lymphoma.
PubCompare.ai utilizes cutting-edge AI technology to help researchers optimize their studies by locatig the best protocols from literature, preprints, and patents, ensuring reproducibility and accuracy in their Intraocular Lymphoma research.

Most cited protocols related to «Intraocular Lymphoma»

1
Optical Bench Evaluation of Intraocular Lenses
Cited 15 times
Through-focus modulation transfer function (MTF) and phase transfer function (PTF) were measured in the Average Corneal Model (ACE) model which reproduces the average spherical aberration and longitudinal chromatic aberration of the cornea [14 (link)]. MTF and PTF can be calculated by the modulus and phase, respectivey, of the Fourier transform of the line spread function measured in the ACE model. Data were collected for six IOL designs (Table 1Designs considered in the study. All the designs are from Abbott Medical Optics Inc (Santa Ana, California).
IOL modelDesignOptics materialTechnologySpherical aberrationa (μm)Add power at IOL plane (D)
ZCB00MonofocalAcrylicRefractive, aspheric−0.27NA
911AMonofocalSiliconeRefractive, spheric + 0.17bNA
ZM900MultifocalSiliconeDiffractive, aspheric−0.27 + 4.00
ZLB00MultifocalAcrylicDiffractive, aspheric−0.27 + 3.25
ZKB00MultifocalAcrylicDiffractive, aspheric−0.27 + 2.75
ZXR00ERVcAcrylicDiffractive, aspheric−0.27NA

Spherical aberration (Zernike coefficient Z12) for a pupil diameter of 6 mm

Spherical aberration provided for a 21.5 D lens and 6 mm pupil.

ERV = extended-range-of-vision IOL.

) of 20 D power in white light from 0 to −3 D. Additionally, the US Air Force (USAF) pictures were recorded under the same conditions. A pupil size of 3 mm was used to evaluate the optical performance based on the average age of cataract patients and the changes in pupil size related to age under photopic conditions [21 (link),22 ].
Based on the optical bench data, the preclinical metrics were calculated for each defocus position for two monofocal IOLs, three multifocal IOLs with different add powers ( +2.75, +3.25 and +4 D) and an extended-range-of-vision (ERV) IOL of 20 D power. These IOL models as well as a description of their base technology are listed in Table 1.
Four different preclinical metrics were evaluated to determine how well they estimate the clinically measured defocus curves and compared to the MTF at 50 and 100 cpmm.
Spatial frequencies in the image plane of 50, 100 and 150 cpmm measured in the ACE model for 20 D IOLs correspond to approximately 15, 30 and 60 cycles per degree respectively in the object plane of a real eye [26 (link)].
To evaluate the performance at intermediate distances, the area under the through-focus VA (AU defocus) was used [27 (link),28 (link)]. The AU defocus was defined as the area under the clinical VA (in decimal units) from −0.5 to −2 D in 0.5 D steps. The AU clinical defocus was correlated with the area under the through-focus curves of the different metrics for the same defocus range (between −0.5 and −2 D).
Alarcon A., Canovas C., Rosen R., Weeber H., Tsai L., Hileman K, & Piers P. (2016). Preclinical metrics to predict through-focus visual acuity for pseudophakic patients. Biomedical Optics Express, 7(5), 1877-1888.
Publication 2016
Cataract Color Vision Cornea Intraocular Lymphoma Lens, Crystalline Light Multifocal Intraocular Lenses Patients Pupil Vision
2
Infant Aphakia Treatment Study
Cited 5 times
This study, supported through a cooperative agreement with the National Eye Institute of the National Institutes of Health, was conducted by the Infant Aphakia Treatment Study Group at 12 clinical sites. The study design, surgical techniques, patching and optical correction regimens, evaluation methods, and patient characteristics at baseline have been reported previously.9 (link),17 (link) This study was approved by the institutional review boards at all participating institutions and was in compliance with the Health Insurance Portability and Accountability Act. The off-label research use of the Acrysof SN60AT and MA60AC IOLs (Alcon Laboratories, Fort Worth, Texas) was covered by US Food and Drug Administration investigational device exemption # G020021.
A Randomized Clinical Trial Comparing Contact Lens to Intraocular Lens Correction of Monocular Aphakia during Infancy: HOTV Optotype Acuity at Age 4.5 Years and Clinical Findings at Age 5 years. (2014). JAMA ophthalmology, 132(6), 676-682.
Publication 2014
Aphakia Ethics Committees, Research Infant Intraocular Lymphoma Medical Devices Operative Surgical Procedures Patients Treatment Protocols
3
Investigational Intraocular Lens Implant
Cited 4 times
The study design, surgical technique, follow-up schedule, patching and optical correction regimens, evaluation methods, and patient characteristics at baseline have been reported in detail previously17 and are only summarized in this report. This study was approved by the institutional review boards of all the participating institutions and was in compliance with the Health Insurance Portability and Accountability Act. The off-label research use of the Acrysof SN60AT and MA60AC IOLs (Alcon Laboratories, Fort Worth, Texas) was covered by US Food and Drug Administration investigational device exemption # G020021.
A Randomized Clinical Trial Comparing Contact Lens to Intraocular Lens Correction of Monocular Aphakia During Infancy: Grating Acuity and Adverse Events at Age 1 Year. (2010). Archives of ophthalmology, 128(7), 810-818.
Publication 2010
Ethics Committees, Research Intraocular Lymphoma Medical Devices Operative Surgical Procedures Patients Treatment Protocols
4
Comparative Analysis of Extended-Range IOLs
Cited 3 times
The following IOLs were included in the analysis: DFT015 (AcrySof IQ Vivity, Alcon Laboratories, Inc.) and SN60WF (AcrySof IQ; Alcon Laboratories, Inc.). The DFT015 is an extended range-of-vision IOL based on a non-diffractive technology called X-wave (X-wave EDOF) [Alcon Data on File, 2019–2020; AcrySof® IQ Vivity™ Extended Vision IOL Directions for Use. Alcon Laboratories, Inc.; 2020]. Specifically, it uses a central 2.2-mm optical zone, containing two non-diffractive transition elements changing the wavefront of the central light beams to elongate the depth of focus. The anterior surface of the IOL is also designed with negative spherical aberration to compensate for the positive spherical aberration of the cornea. The result is a continuous extended focal range with monofocal visual disturbances profile [Alcon Data on File, 2019–2020; AcrySof® IQ Vivity™ Extended Vision IOL Directions for Use. Alcon Laboratories, Inc.; 2020]. The SN60WF is an aspheric biconvex monofocal IOL, with a reported 0.20 μm of negative spherical aberration. The DFT015 and the SN60WF share the same ultraviolet and blue light filtering acrylate/methacrylate copolymer. Their optic diameter is 6 mm, and the overall length is 13 mm. Both IOLs have modified L-loop haptics, with no angulation and a square edge interrupted at the optic-haptic junction. Their refraction index is 1.55 at 35°. The IOL power range varies from + 15.0 to + 25.0 D (step 0.5 D) for the DFT015 and from + 6.0 to + 30.0 (step 0.5 D) for the SN60WF. The same power was used for all IOLs included in the analysis (+ 20D). For each model, three IOLs were consecutively tested.
Tognetto D., Giglio R., De Giacinto C., Pastore M.R., Cirigliano G., Piñero D.P, & Turco G. (2021). Profile of a new extended range-of-vision IOL: a laboratory study. Graefe's Archive for Clinical and Experimental Ophthalmology, 260(3), 913-916.
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Publication 2021
acrylate Cornea Eye Intraocular Lymphoma Light Methacrylate Strains Transition Elements Vision
5
Tecnis IOL Implantation in Cataract Patients
Cited 3 times
We reviewed the cases of cataract patients who underwent bilateral implantation of Tecnis monofocal IOLs (ZCB00) or Tecnis multifocal IOLs (ZMB00) from December 13, 2010, to July 29, 2019, with the right and left lenses implanted within 3 months of each other. The exclusion criteria were a history of other ocular diseases that could affect visual function, |subjective equivalent (SE)|> 2.00 dioptres, |subjective refraction cylinder (CYL)|> 3.00 dioptres and |corneal astigmatism (keratometric cylinder)|> 3.00 dioptres at 10 weeks after surgery.
Tanabe H., Tabuchi H., Shojo T., Yamauchi T, & Takase K. (2020). Comparison of visual performance between monofocal and multifocal intraocular lenses of the same material and basic design. Scientific Reports, 10, 15490.
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Publication 2020
Cataract Corneal Astigmatism Intraocular Lymphoma Lens, Crystalline Multifocal Intraocular Lenses Ocular Refraction Operative Surgical Procedures Ovum Implantation Patients Vision

Most recents protocols related to «Intraocular Lymphoma»

1
Evaluating Dysphotopsia Reduction in IOLs
The effect of violet light-filtering and manufacturing improvements of ZXR00V versus ZXR00 on preclinical assessment of dysphotopsias was determined by in vitro measurements and computer simulation models of light scatter.
The straylight parameter15 (link) was calculated by in vitro assessment of halos using a model eye with realistic eye dimensions with a 4-mm aperture, a cornea exhibiting the average spherical and chromatic aberration, a CCD detector and a fiber with 2 mm diameter powered by a xenon car headlight placed approximately 2.8 m on-axis in front of the model eye.16 (link) This setup is able to discriminate performance of monofocal, multifocal and extended range of vision IOL lenses as shown by the intensity recordings in Figure 8 from Weeber et al16 (link) using a small extended light source. Halos were assessed by measuring the radial intensity profiles for the ZXR00V and ZXR00 IOLs. A total of 32 individual images tested at different shutter times were recorded for each IOL model, resulting in high-dynamic-range halo images with more than seven decades of intensity. Three of these images were recorded for each IOL, and the mean radial intensity profiles were averaged up to 1 degree and multiplied by the square of the field angle to obtain the straylight parameter. The total intensity across the full field of 1 degree was used as normalization and the area under the curve for the straylight parameter was used to compare the outcomes for ZXR00V versus ZXR00.
A computer simulation study using MATLAB software (MathWorks Inc., USA) was also performed, and radial intensity profiles were determined using the same theoretical corneal eye model used in the in vitro assessment.17 (link) The geometrical shape of the IOLs was modelled including the echelette profiles. Wavefront propagation calculation assured that the induced phase by the echelettes was included to calculate the radial intensity. The eye model is based on realistic eye dimensions and a uniform lighting source and the photopic sensitivity of the eye was used to calculate the straylight parameter for the ZXR00V and ZXR00 IOLs. Pupil sizes used for the study ranged from 3 to 5 mm, and angular size of the extended light source ranged from 0.7 to 2.40 arcminute. The straylight level of a healthy crystalline lens calculated from the standard glare observer15 (link),18 was used as a threshold level. The area between the simulated straylight parameter for the ZXR00V and ZXR00 IOLs and the threshold curve of the crystalline lens was used as basis for comparison.
van der Mooren M., Alarcon A., Jenkins Sanchez M.D, & Chang D.H. (2023). Effect of Violet Light-Filtering and Manufacturing Improvements in an Extended Depth-of-Focus Intraocular Lens on Visual Performance. Clinical Ophthalmology (Auckland, N.Z.), 17, 701-709.
Publication 2023
A Fibers Color Vision Cornea Epistropheus Glare Hypersensitivity Intraocular Lymphoma Lens, Crystalline Light Pupil Viola Vision Xenon
2
Retinal Veiling Luminance Reduction Protocol
Integration of the straylight parameter over an angular range was used to calculate the potential reduction in retinal veiling luminance (RVL)19 (link) with ZXR00V versus ZXR00. Under challenging light conditions, such as night driving with low road luminance and an oncoming car with intense headlights, the relative contrast enhancement was calculated for the scenario of a pedestrian crossing the road, as would be predicted to be observed by a pseudophakic patient implanted with either the ZXR00V or ZXR00 IOLs. The contrast is defined as the difference of the luminance target (pedestrian, Lt) and background luminance (road, Lb) divided by sum of luminance background and RVL as per the following equation:
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\DeclareFontFamily{T1}{linotext}{}
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\begin{document}
$${\rm{contrast\,ratio={{Lt-Lb} \over {Lb+RVL}}}}$$
\end{document}Pedestrian luminance of 2 cd/m2 and 5 cd/m2 and road luminance ranging between 0.2 and 1 cd.m2 were chosen as realistic values for challenging light conditions at night.20 (link)
van der Mooren M., Alarcon A., Jenkins Sanchez M.D, & Chang D.H. (2023). Effect of Violet Light-Filtering and Manufacturing Improvements in an Extended Depth-of-Focus Intraocular Lens on Visual Performance. Clinical Ophthalmology (Auckland, N.Z.), 17, 701-709.
Publication 2023
Intraocular Lymphoma Light Patients Pedestrians Retina
3
Analyzing Intraocular Lens Technology Trends
We evaluated the technological development patterns and newly emerged technologies of IOLs using a text-based analysis method using three types of data: patents, papers, and clinical trials. We used the methodologies of Niemann et al. [21 (link)], Block et al. [22 (link)], and Wustmans et al. [23 (link)] to compare the patents, papers, and clinical trials. In other words, if the words used in each document were similar, it was assumed that the content was also similar. Using this method, Niemann et al. [21 (link)] analyzed the similarity between patents, Block et al. [22 (link)] analyzed the similarity between patents and papers, and Wustmans et al. [23 (link)] analyzed the similarity between patents and trend data. Our research method is illustrated in Figure 1.
Kim H., Jeong H, & Shin K. (2023). Development Pattern of Medical Device Technology and Regulatory Evolution of Cataract Treatment. Healthcare, 11(4), 453.
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Publication 2023
Intraocular Lymphoma
4
Intravitreal Methotrexate and Rituximab for Intraocular Lymphoma
Patients with intraocular lymphoma were treated with intravitreal methotrexate and rituximab injections as described by Yeh and Wilson [22 (link)].
Kuitunen H.K., Rönkä A.L., Sonkajärvi E.M., Isokangas J.M., Pyörälä M., Palosaari K.A., Jokimäki A.S., Partanen A.E., Littow H.J., Vakkala M.A., Jantunen E.J., Huttunen M.E., Marin K.J., Aromaa-Häyhä A.M., Auvinen P.K., Selander T., Puhakka I.K, & Kuittinen O.M. (2023). Blood–Brain Barrier Disruption (BBBD)-Based Immunochemotherapy for Primary Central Nervous System Lymphoma (PCNSL), Early Results of a Phase II Study. Cancers, 15(4), 1341.
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Publication 2023
Intraocular Lymphoma Methotrexate Patients Rituximab
5
Cerebrospinal Fluid Interleukin-10 in Primary and Secondary CNS Lymphoma
The patient cohorts of this study included ten newly diagnosed PCNSL patients and eleven other CNSL patients, including three with refractory/recurrence (R/R) PCNSL, two with primary intraocular lymphoma (PIOL) with central nervous system (CNS) progression, two with systemic DLBCL relapsed in the CNS, one with newly diagnosed systemic DLBCL involving the CNS, and three with newly diagnosed PIOL. All patients were treated at Peking Union Medical College Hospital, Beijing, China.
The diagnosis and response assessments of PCNSL were made with reference to the guidelines formulated by the International Primary CNS Lymphoma Collaborative Group in 2005 [17 (link)]. Patients with positive human immunodeficiency virus or Epstein-Barr virus were excluded. Each patient signed a written informed consent document prior to the study. The study was approved by the ethical committee at our hospital and was performed in accordance with the Declaration of Helsinki (no. ZS-2040).
Patients with newly diagnosed PCNSL received lumber puncture at baseline, before each cycle of chemotherapy, every three months during maintenance therapy, and at the time of relapse or progression. Patients with other CNLs received lumber puncture before chemotherapy. One microliter of CSF was used to measure IL-10 concentration for four hours for the detection. The rest of the CSF samples (five to ten microliters) and matched buccal mucosa were stored at −80°C. Formalin-fixed paraffin-embedded (FFPE) tumor tissues were obtained and stored at room temperature prior to DNA extraction.
Wang W., Zou D., Zhuang Z., Zhang X., Zhang L., Yin J., Jia C., Yuan L., Cai H., Zhang Y., Wang X., Zhang M., Zhou D, & Zhang W. (2023). Cell-Free DNA in Cerebrospinal Fluid Complements the Monitoring Value of Interleukin-10 in Newly Diagnosed Primary Central Nervous System Lymphoma. Journal of Oncology, 2023, 5808731.
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Publication 2023
Buccal Mucosa Central Nervous System Disease Progression Epstein-Barr Virus Formalin HIV Seropositivity IL10 protein, human Intraocular Lymphoma Lymphoma Neoplasms Paraffin Patients Pharmacotherapy Punctures Recurrence Relapse Therapeutics Tissues

Top products related to «Intraocular Lymphoma»

1
Acrysof sn60at by Alcon
The Acrysof SN60AT is a foldable intraocular lens (IOL) designed for cataract surgery. It features a single-piece acrylic lens with a 6.0 mm optic and an overall diameter of 13.0 mm. The lens is designed to be implanted in the capsular bag following the removal of the natural lens during cataract surgery.
2
Ma60ac iols by Alcon
Sourced in United States
The MA60AC IOLs are intraocular lenses (IOLs) designed for use in cataract surgery. They are made of acrylic material and feature a 6.0 mm optic diameter. The MA60AC IOLs are intended to be implanted in the capsular bag following the removal of the natural crystalline lens.
3
Trypsin edta by Thermo Fisher Scientific
Sourced in United States, United Kingdom, Germany, Canada, Switzerland, France, China, Australia, Japan, Italy, Spain, New Zealand, Sweden, Singapore, Portugal, Thailand, Belgium, Denmark, Taiwan, Province of China, Ireland, Brazil, Netherlands, Austria, Czechia, India, Morocco, Israel, Poland, Macao
Trypsin-EDTA is a solution used in cell culture applications to dissociate adherent cells from their growth surface. It contains the proteolytic enzyme trypsin and the chelating agent EDTA, which work together to break down the cellular adhesions and allow the cells to be harvested and passaged.
4
Iolmaster 700 by Zeiss
Sourced in Germany, United States, Ireland, Italy, Japan
The IOLMaster 700 is an optical biometry device designed for accurate measurement of the eye's components. It utilizes optical coherence tomography (OCT) technology to provide precise data on the axial length, anterior chamber depth, and corneal curvature of the eye.
5
Sn60wf by Alcon
Sourced in United States
The SN60WF is an intraocular lens (IOL) designed for cataract surgery. It is a single-piece, foldable IOL made of hydrophobic acrylic material. The lens has a 6.0 mm optic and an overall diameter of 13.0 mm.
6
Bluemixs 180 by Zeiss
Sourced in Germany
The BLUEMIXS 180 is a compact and versatile benchtop microfluidic mixer designed for precise and efficient mixing of small liquid samples. It utilizes a proprietary microfluidic mixing technology to ensure rapid and homogeneous mixing of volumes ranging from microliters to milliliters.
7
Glycidyl methacrylate by Merck Group
Sourced in United States, Germany, Italy, United Kingdom, Poland, Chile, France, Sao Tome and Principe
Glycidyl methacrylate is a chemical compound used in the production of various synthetic polymers. It is a bifunctional monomer, containing both an epoxide group and a methacrylate group, which allows it to participate in a range of polymerization reactions. The core function of glycidyl methacrylate is to serve as a building block in the synthesis of specialty polymers and copolymers, which find applications in diverse industries.
8
Acrysof iq sn60wf by Alcon
Sourced in United States, Switzerland
The AcrySof IQ SN60WF is an intraocular lens (IOL) designed for cataract surgery. It is made of a foldable acrylic material and has a single-piece design. The lens features a wavefront-designed optic that is intended to provide improved visual outcomes for patients.
9
Acrysof iq restor sn6ad1 by Alcon
Sourced in United States
The AcrySof IQ ReSTOR SN6AD1 is an intraocular lens (IOL) designed for cataract surgery. It is a posterior chamber IOL intended for the visual correction of aphakia in adult patients in whom a cataract and the intraocular lens have been removed by extracapsular cataract extraction. The lens features a patented apodized diffractive technology and is made of a foldable acrylic material.
10
Centurion vision system by Alcon
Sourced in United States, Switzerland
The Centurion Vision System is a specialized ophthalmic surgical device designed for cataract surgery. It provides precise control and customization of various surgical parameters to assist ophthalmologists during the procedure.

More about "Intraocular Lymphoma"

Intraocular Lymphoma, also known as ocular lymphoma or primary intraocular lymphoma, is a rare and aggressive form of eye cancer that develops when lymphocytes, a type of white blood cell, grow uncontrollably within the eye.
This condition can lead to a variety of vision problems, including blurred vision, eye pain, and other serious complications if left untreated.
Researchers and ophthalmologists must utilize the most effective treatment approaches and products to ensure accurate diagnosis and effective management of Intraocular Lymphoma.
PubCompare.ai, a cutting-edge AI-powered platform, helps optimize Intraocular Lymphoma research by identifying the best protocols from literature, preprints, and patents, ensuring reproducibility and accuracy.
When studying Intraocular Lymphoma, researchers may also consider other related ophthalmic products and technologies, such as Acrysof SN60AT and MA60AC intraocular lenses (IOLs), Trypsin-EDTA for cell culture, the IOLMaster 700 biometry device, the SN60WF and BLUEMIXS 180 IOLs, and Glycidyl methacrylate for polymer synthesis.
The AcrySof IQ SN60WF and AcrySof IQ ReSTOR SN6AD1 IOLs, as well as the Centurion Vision System, may also be relevant in the context of Intraocular Lymphoma research and treatment.
By leveraging the latest AI-driven tools and a comprehensive understanding of Intraocular Lymphoma and related ophthalmic technologies, researchers can optimize their studies, ensure reproducibility, and ultimately improve the diagnosis and management of this rare and aggressive form of eye cancer.