> Disorders > Neoplastic Process > Multiple Endocrine Neoplasia Type 2b

Multiple Endocrine Neoplasia Type 2b

Multiple Endocrine Neoplasia Type 2b is a rare, inherited disorder characterized by the development of tumors in multiple endocrine glands.
This condition is caused by genetic mutations that lead to the uncontrolled growth of cells, resulting in the formation of tumors in the thyroid, adrenal glands, and other endocrine tissues.
Paitents with Multiple Endocrine Neoplasia Type 2b may experience a variety of symptoms, including thyroid nodules, pheochromocytoma, and mucosal neuromas.
Early diagnosis and appropriate management are crucial for improving patient outcomes and reducing the risk of complications.
The PubCommpare.ai platform can help researchers identify the best protocols from literature, preprints, and patents, enabling optimized and reproducible research on this complex condition.

Most cited protocols related to «Multiple Endocrine Neoplasia Type 2b»

Age-Stratified Population-Based Cohort Study

Cited 40 times

The study design comprised an age and gender stratified random sample of residents of the city of Leipzig, in the age group of 40 to 79 years. A subset of 400 participants aged 18 to 39 years was also recruited. In total, 10,000 participants were planned as the target population (Fig. 1). Address lists of randomly sampled citizens were provided by the resident’s registration office of the city of Leipzig. Citizens were sent an invitation letter containing an information leaflet about the study, a response form and a postage-paid return envelope. Persons who did not respond within four weeks received a reminder letter. Non-responders were searched in public telephone directories and contacted by phone. Persons who were interested to participate were scheduled for an appointment in the LIFE study centre. As a prerequisite to enrolment, written informed consent was obtained from all participants. The study was approved by the responsible institutional ethics board of the Medical Faculty of the University of Leipzig. The data privacy and safety concept of the study was approved by the responsible data protection officer. Possible incidents during study visits and during travel to the study site were covered by an insurance policy. Participants received a lump sum of 20 EUR per visit to cover their travel expenses. No other financial incentives were paid out. We carried out several public relation activities to stimulate participation rates. The LIFE study centre was located on the medical campus in the centre of the city, which was easy to reach.Fig. 1

Target sample sizes of the LIFE-Adult-Study

In March 2013, we decided to modify the inclusion criteria of the programme with a reduction of the upper age limit to 74 years. We observed that participants aged ≥75 years had difficulties in completing the assessment programme within the set time limit despite high motivation. Furthermore, it became apparent that participation of women in this age group was markedly reduced (about 1/3 lower than men). The most frequently given reason was that women would not leave their diseased and care-needing partners alone at home on three study days. Therefore, as we stopped recruitment of participants ≥75 years, we extended the lower age limit for deep cognition and depression phenotyping to 60 years. This change was put in place in March 2013 after approval by the institutional ethics board.
In a subset of participants we investigated whether body fat distribution is associated with functional traits of the brain (magnetic resonance imaging, MRI) and traits of eating behaviour. To unravel this question a subcohort of 1200 participants aged 18-79 underwent abdominal MRI-scans in addition to brain MRI-scans.

Loeffler M., Engel C., Ahnert P., Alfermann D., Arelin K., Baber R., Beutner F., Binder H., Brähler E., Burkhardt R., Ceglarek U., Enzenbach C., Fuchs M., Glaesmer H., Girlich F., Hagendorff A., Häntzsch M., Hegerl U., Henger S., Hensch T., Hinz A., Holzendorf V., Husser D., Kersting A., Kiel A., Kirsten T., Kratzsch J., Krohn K., Luck T., Melzer S., Netto J., Nüchter M., Raschpichler M., Rauscher F.G., Riedel-Heller S.G., Sander C., Scholz M., Schönknecht P., Schroeter M.L., Simon J.C., Speer R., Stäker J., Stein R., Stöbel-Richter Y., Stumvoll M., Tarnok A., Teren A., Teupser D., Then F.S., Tönjes A., Treudler R., Villringer A., Weissgerber A., Wiedemann P., Zachariae S., Wirkner K, & Thiery J. (2015). The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany. BMC Public Health, 15, 691.

Publication 2015

Abdomen Adult Age Groups Brain Cognition Faculty, Medical Feeding Behaviors Gender Motivation MRI Scans Multiple Endocrine Neoplasia Type 2b Safety Target Population Woman

Genetics of Premature Coronary Artery Disease

Cited 14 times

The study complies with the Declaration of Helsinki and was approved by the Ethics Committee of the Instituto Nacional de Cardiología Ignacio Chávez (INCICH). All participants provided written informed consent. The study included 1162 patients with premature CAD and 873 healthy controls belonging to the Genetics of Atherosclerotic Disease (GEA) Mexican Study. Premature CAD was defined as history of myocardial infarction, angioplasty, revascularization surgery, or coronary stenosis > 50% on angiography, diagnosed before age of 55 in men and before age of 65 in women. Controls were apparently healthy asymptomatic individuals without family history of premature CAD, recruited from blood bank donors and through brochures posted in Social Service centers. Chest and abdomen computed tomographies were performed using a 64-channel multidetector helical computed tomography system (Somatom Sensation, Siemens) and interpreted by experienced radiologists. Scans were read to assess and quantify the following: (1) coronary artery calcification (CAC) score using the Agatston method [20 (link)] and (2) total adipose tissue (TAT) and subcutaneous and visceral adipose tissue areas (SAT and VAT) as described by Kvist et al. [21 (link)]. For the present study, the control group only included individuals with CAC = 0, who were nondiabetic, and with normal glucose levels (n = 873). In the whole sample, the demographic, clinical, anthropometric, and biochemical parameters and cardiovascular risk factors were evaluated and defined as previously described [22 –24 (link)]. Briefly, hypercholesterolemia was defined as total cholesterol (TC) levels ≥ 200 mg/dL. Hypertension was defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg or the use of oral antihypertensive therapy. Type 2 diabetes mellitus (T2DM) was defined with a fasting glucose ≥ 126 mg/dL and was also considered when participants reported glucose-lowering treatment or a physician diagnosis of T2DM. Obesity was defined as body mass index (BMI) ≥ 30 kg/m². Hypoalphalipoproteinemia, hypertriglyceridemia, and metabolic syndrome (MS) were defined using the criteria from the American Heart Association, National Heart, Lung, and Blood Institute Scientific Statement [25 (link)], except for central obesity that was considered when waist circumference was 90 cm in men and 80 cm in women [26 (link)]. Hyperuricemia was considered with a serum uric acid > 6.0 mg/dL and >7.0 mg/dL for women and men, respectively [27 (link)]. Insulin resistance was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR). The presence of insulin resistance was considered when the HOMA-IR values were ≥75th percentile (3.66 in women and 3.38 in men). Hyperinsulinemia was defined when insulin concentration was ≥75th percentile (16.97 μIU/mL in women and 15.20 μIU/mL in men). Hypoadiponectinemia was defined when adiponectin concentration was ≤25th percentile (8.67 μg/mL in women and 5.30 μg/mL in men). Increased VAT was defined as VAT ≥ 75th percentile (122.0 cm² in women and 151.5 cm² in men) and increased SAT as SAT ≥ 75th percentile (335.5 cm² in women and 221.7 cm² in men). Elevated alanine aminotransferase (ALT) was defined as ALT activity ≥ 75th percentile (21.0 IU/L in women and 24.5 IU/L in men). Elevated aspartate aminotransferase (AST) was defined as AST activity ≥ 75th percentile (25 IU/L in women and 28 IU/L in men) and elevated gamma glutamyltransferase (GGT) was defined as GGT ≥ 75th percentile (21.0 IU/L in women and 27.5 IU/L in men). These cutoff points were obtained from a GEA study sample of 131 men and 185 women without obesity and with normal values of blood pressure, fasting glucose, and lipids.
All GEA participants are unrelated and of self-reported Mexican-Mestizo ancestry (three generations). In order to establish the ethnical characteristics of the studied groups, we analyzed 265 ancestry informative markers (AIMs). Using the ADMIXTURE software, the Caucasian, Amerindian, and African backgrounds were determined. Similar background in premature CAD patients and healthy controls was found (P > 0.05). Patients showed 55.8% of Amerindian ancestry, 34.3% of Caucasian ancestry, and 9.8% of African ancestry, whereas controls showed 54.0% of Amerindian ancestry, 35.8% of Caucasian ancestry, and 10.1% of African ancestry.

Posadas-Sánchez R., Pérez-Hernández N., Angeles-Martínez J., López-Bautista F., Villarreal-Molina T., Rodríguez-Pérez J.M., Fragoso J.M., Posadas-Romero C, & Vargas-Alarcón G. (2017). Interleukin 35 Polymorphisms Are Associated with Decreased Risk of Premature Coronary Artery Disease, Metabolic Parameters, and IL-35 Levels: The Genetics of Atherosclerotic Disease (GEA) Study. Mediators of Inflammation, 2017, 6012795.

Publication 2017

Abdomen Adiponectin Angiography Angioplasty Antihypertensive Agents Artery, Coronary Aspartate Transaminase BLOOD Blood Pressure Calcinosis Chest Cholesterol Coronary Stenosis D-Alanine Transaminase Diabetes Mellitus, Non-Insulin-Dependent Diagnosis Donor, Blood Ethics Committees gamma-Glutamyl Transpeptidase Glucose Heart Hereditary Diseases High Blood Pressures Homeostasis Hypercholesterolemia Hyperinsulinism Hypertriglyceridemia Hyperuricemia Hypoadiponectinemia Hypoalphalipoproteinemias Index, Body Mass Insulin Insulin Resistance Lipids Lung Metabolic Syndrome X Multiple Endocrine Neoplasia Type 2b Myocardial Infarction Negroid Races Obesity Operative Surgical Procedures Patients Physicians Premature Birth Pressure, Diastolic Radiologist Radionuclide Imaging Serum Subcutaneous Fat Systolic Pressure Tissue, Adipose Tomography, Spiral Computed Uric Acid Waist Circumference White Person Woman X-Ray Computed Tomography

Standardized echocardiography protocol for aortic stenosis

Cited 10 times

Echocardiograms were performed at baseline, annually and before planned aortic valve surgery following a standardized protocol at 173 study centers in 7 European countries. Echocardiographic images were stored on videotapes, compact discs, or magnetic optical discs and forwarded for blinded interpretation at the SEAS echocardiography core laboratory at Haukeland University Hospital, Bergen, Norway, as previously published.^{5 (link),12 (link),14 (link)} Severity of AS and LV structure and function were measured following current guidelines.^{15 (link),16 (link)} LV mass was measured by an autopsy-validated method and indexed to body height in the allometric power of 2.7.^{17 (link)} LV hypertrophy was defined using the prognostically validated cutoff values LV mass index >46.7 g/m^2.7 in women and >49.2 g/m^2.7 in men.^{3 (link)} Relative wall thickness was assessed from 2×LV posterior wall thickness/LV end-diastolic diameter ratio and considered increased if >0.43 (concentric LV geometry).^{15 (link)} Valvuloarterial impedance was calculated using a previously validated method.^{18 (link)} Pressure recovery was assessed at the aortic sinotubular junction and used for calculation of energy loss index as prognostically validated.^{19 (link),20 (link)}

Gerdts E., Rossebø A.B., Pedersen T.R., Cioffi G., Lønnebakken M.T., Cramariuc D., Rogge B.P, & Devereux R.B. (2015). Relation of Left Ventricular Mass to Prognosis in Initially Asymptomatic Mild to Moderate Aortic Valve Stenosis. Circulation. Cardiovascular Imaging, 8(11), e003644.

Publication 2015

Aorta Autopsy Body Height Diastole Echocardiography Europeans Fatigue Left Ventricular Hypertrophy Multiple Endocrine Neoplasia Type 2b Operative Surgical Procedures Pressure Sinotubular Junction Valves, Aortic Vision Woman

Participatory Qualitative Approach to Develop Vignette

Cited 10 times

The vignette was developed through PLA activities conducted with 3 groups of men and 3 groups of women from different residence areas, each group comprising 8–12 participants. Participants were selected from a sampling frame of men and women aged 15–60 who had at least 1 child. This selection was random, with the exception of a few female HIV-positive individuals (‘seeds’) who were purposively selected from the sampling frame by the principal investigator using the community HIV sero-surveillance data. Female groups included 1–5 HIV-positive ‘seeds’ (see Buzsa et al. for details of the seeded focus group method [35 (link)]). Fieldworkers were unaware of the HIV status of all individuals on the recruitment lists and those participating in the activities. Each PLA was facilitated in Kiswahili (commonly spoken national language) by an experienced fieldworker of the same sex as participants. A second fieldworker took notes on the content of discussions, details of the role-play storyline and behaviours of characters, as well as general observations of the group dynamic. The majority of sessions were attended by the principal investigator. Activities were audio-recorded following informed consent from participants.
PLA activities included brainstorming and ranking of barriers, role-playing and group discussion (Table 1). Before the role-plays, fieldworkers facilitated a discussion to identify the central characters that would be involved in a woman’s pregnancy and delivery. Thereafter, the participants were instructed to invent a storyline of a (fictitious) woman who discovers she is HIV-positive at ANC, thinking of the issues that a real woman in their village would face and the decisions she would make when trying to use PMTCT services. Participants then acted the play to the facilitator and observers. De-briefing sessions with fieldworkers were conducted following each PLA activity, informing an initial analysis of emerging themes which was used together with PLA notes by the project investigator to draft the vignette.
To compose the vignette storyline, unifying and contrasting elements of the role-plays were identified. Discussions following the role-plays, during which facilitators discussed how realistic the storylines were, were then analysed to confirm unifying elements, or resolve differences between the stories. Themes emerging from other activities, particularly barriers deemed most important in the ranking exercise, were also considered. The final vignette also needed to be viable given the character’s profile, for example, to represent the issues that the character would face considering their residence, marital status or family circumstances. The aim was to present a story that was familiar to most participants (touching on personal experiences, or experiences of acquaintances in their community), but that also achieved the objective of making women feel comfortable to admit to any difficulties they faced (so, for example, a more extreme case of a woman failing to access several of the services was chosen). Overly emotional circumstances or events (e.g. teenage pregnancy or death of a baby) which might derail the interview were avoided.
Once developed, the vignette and associated questions were incorporated into an interview discussion guide, along with open-ended questions about the personal experiences of the respondent during pregnancy, delivery and infant feeding. As conceived in the original study design, fieldworkers then received an additional day of training on the concept and use of the vignette, including examples of other studies employing this technique [24 (link)], and on confidentiality (particularly if participants disclosed their HIV status during the interviews). This additional training session was intended to give fieldworkers the chance to familiarise themselves with and discuss the vignette developed from the PLAs, and to ensure the associated methods were fresh in fieldworkers’ minds prior to commencing the interviews. Fieldworkers were asked to review the vignette, and comment on how well it reflected the role-plays and major themes identified from the PLAs (no amendments were suggested). They were instructed to probe for whether responses to the vignette (what participants thought the character in the story would do) reflected real life in their community. After training, fieldworkers practised the questionnaire among themselves and with volunteer participants.

Gourlay A., Mshana G., Birdthistle I., Bulugu G., Zaba B, & Urassa M. (2014). Using vignettes in qualitative research to explore barriers and facilitating factors to the uptake of prevention of mother-to-child transmission services in rural Tanzania: a critical analysis. BMC Medical Research Methodology, 14, 21.

Publication 2014

Acquaintances Biological Community Character Child Emotions Feelings Females Infant Multiple Endocrine Neoplasia Type 2b Obstetric Delivery Plasma Pregnancy Reading Frames Voluntary Workers Woman

Cardiometabolic Diseases in Suburban Shanghai

Cited 9 times

The Shanghai Nicheng Cohort Study was designed to assess the prevalence, incidence, and related factors of cardiometabolic diseases among adults in Nicheng County, a suburb of Shanghai, China. The baseline survey was conducted between April 2013 and August 2014. The target population covered 23,375 residents aged 45–70 years who had lived in Nicheng County for at least 5 years. A total of 21,408 residents were enrolled, and 17,212 participants finished the baseline survey (mean age 56.9, proportion of Men 45.3%). We excluded the participants without data on BMI, waist circumference or body fat percentage (n = 1091), fasting or 2-h glucose (n = 75), subcutaneous fat area (SFA) and visceral fat area (VFA) (n = 2861), and the participants with a history of diabetes (n = 1048). We excluded the participants with previously diagnosed diabetes because body weight changes have been reported for diabetes treatment in patients with known diabetes. The final sample in the present cross-sectional analysis comprised 12,137 participants (mean age 56.7, proportion of Men 44.5%), the participation flowchart was shown in Additional file 1. The study was approved by the Independent Ethics Community of Shanghai Sixth People’s Hospital and written informed consent was obtained from each participant.

Chen P., Hou X., Hu G., Wei L., Jiao L., Wang H., Chen S., Wu J., Bao Y, & Jia W. (2018). Abdominal subcutaneous adipose tissue: a favorable adipose depot for diabetes?. Cardiovascular Diabetology, 17, 93.

Publication 2018

Adult Body Fat Diabetes Mellitus Glucose Multiple Endocrine Neoplasia Type 2b Patients Subcutaneous Fat Target Population Visceral Fat Waist Circumference

Most recents protocols related to «Multiple Endocrine Neoplasia Type 2b»

Gait and Eye Tracking in Healthy Adults

Participants were recruited via a TU-Chemnitz online mailing list and could participate if they had self-reported normal or corrected-to-normal vision (≤ ± 7 dpt when uncorrected, contact lenses were permitted), no neurological or walking impairments, and a body mass of 130 kg or less. Visual and body mass-based exclusion criteria were based on the device limits of the eye tracker and the treadmill, respectively. All participants reported being sufficiently rested and focused in a questionnaire prior to the experiment, were naïve to the hypotheses and debriefed after the experiment. We aimed for a power of 80% (Cohen 1988 ) which, given

α = . 05

and Cohen’s

f = 0.25

(a realistic estimate based on previous work, Kopiske et al. 2021 (link)), required a sample size of

N = 24

. A total of 27 participated, as after inspecting data quality, but prior to any hypothesis-related analysis, data of three participants had to be excluded due to a high proportion of missing eye-tracking data (> 20% missing values, same cutoff as used in Kopiske et al. 2021 (link)).
The analyzed sample of N = 24 included 14 women and 10 men with an average age of 24.3 years (between 19 and 34), average height 173 cm ± 9 cm (standard deviation), average body mass 68 kg ± 15 kg and average leg length 94 cm ± 6 cm. These biometric measurements were required for modeling motion tracking. For participation, participants received either course credit or a monetary reimbursement of 8€/h. All experimental procedures were approved by the Chemnitz University of Technology, Faculty of Behavioral and Social Sciences ethics committee (case no.: V-314-PHKP-WETGRAIL01-17012019). Participant data were protected following the guidelines for data management and data sharing of the German DGPs (Gollwitzer et al. 2020 ).

Müller C., Baumann T., Einhäuser W, & Kopiske K. (2023). Slipping while counting: gaze–gait interactions during perturbed walking under dual-task conditions. Experimental Brain Research, 241(3), 765-780.

Publication 2023

A-130A Contact Lenses Ethics Committees Faculty Human Body Medical Devices Multiple Endocrine Neoplasia Type 2b Woman

Reliability of Foot Angle and Area

The reliabilities of intersecting angle and footprint area measurements were examined for 10 feet from 5 Japanese fixed cadavers (mean age at death, 72.8 ± 15.9 years; 3 sides from men, 2 sides from women, 5 right sides, and 5 left sides) with no history of ankle or ankle joint surgery. Intersecting angles were measured as described above, and re-measurements were taken on the same day as the first measurement. The footprint area was measured by the method described above, and re-measurements were taken the next day or later.

Togashi R., Edama M., Shagawa M., Osanami H., Yokota H., Hirabayashi R., Sekine C., Ishigaki T., Akuzawa H., Yamada Y., Toriumi T, & Kageyama I. (2023). Relationship between Joint and Ligament Structures of the Subtalar Joint and Degeneration of the Subtalar Articular Facet. International Journal of Environmental Research and Public Health, 20(4), 3075.

Publication 2023

Ankle Cadaver Foot Japanese Joints, Ankle Multiple Endocrine Neoplasia Type 2b Operative Surgical Procedures Woman

Nutritional Assessment in Coronary Artery Disease

Statistical analyses were performed with the RStudio software v. 4.2.0. The normality of the distribution of each parameter was checked by the Shapiro–Wilk test. The variables were presented as means (±SD).
Pearson correlation was used to analyze the linear association between selected nutritional status parameters to investigate if patients are properly assessed at the time of hospital admission. The cut-off points used for the correlation coefficient were as follows: <0.30 as low, 0.30–0.49 as moderate, and ≥0.50 as high correlation. A p-value below 0.05 was considered significant.
Then the patients were divided into two subgroups by clinical performance according to CCS class, i.e., CCS ≤ 2 or CCS ≥ 3. The comparison between the subgroup was performed with the Mann-Whitney-U test. A p-value below 0.05 was considered significant.
The patients were also divided into 5 subgroups by CCS class. The one-way ANOVA test was used to compare the BIA and anthropometrical parameters between these multiple groups. Then the linear correlation between nutritional status parameters and CCS class was investigated with the Pearson correlation test. The cut-off points used for the correlation coefficient were the same as above: <0.30 as low, 0.30–0.49 as moderate, and ≥0.50 as high correlation. A p-value below 0.05 was considered significant.
The correlation was also investigated between nutritional status parameters and the number of lesioned coronary vessels or LVEF. The cut-off points used for the correlation coefficient were the same as above: <0.30 as low, 0.30–0.49 as moderate and ≥0.50 as high correlation. A p-value below 0.05 was considered significant.
Finally, the patients were divided into subgroups by sex (men and women) in which the mentioned analyses were also performed. The subgroup included equal numbers of women (n = 25) and men (n = 25). Women were older (mean age: 69.3 ± 9.6 years) than men (mean age: 65.8 ± 8.3 years). Women had less advanced CAD (mean of 0.96 ± 1.06 significantly lesioned coronary arteries in women vs. 1.48 ± 1.26 in men), but they had more severe symptoms (mean CCS score 2.00 ± 1.15 in women vs. 1.92 ± 0.95 in men). In terms of nutritional status women were characterized by lower nutritional risk (mean NRS 2002 0.40 ± 0.50 points in women vs. 0.44 ± 0.65 points in men), higher BMI (29.72 ± 4.17 kg/m² in women vs. 28.55 ± 3.08 kg/m² in men) and lower PA measured at 50 kHz (5.12 ± 1.12° in women vs. 5.58 ± 0.95° in men).

Popiolek-Kalisz J, & Blaszczak P. (2023). Nutritional Status of Coronary Artery Disease Patients—Preliminary Results. International Journal of Environmental Research and Public Health, 20(4), 3464.

Publication 2023

Artery, Coronary Coronary Vessels Multiple Endocrine Neoplasia Type 2b neuro-oncological ventral antigen 2, human Patients Woman

Online Survey on IT Innovation Risks

We used a survey company that obtains samples from registered respondents. The company disseminated the online questionnaires that we designed for the experiment and the entire survey process was conducted online. We performed an RCT to identify the effects of our nudge message on attitudes toward IT innovation risks compared with simpler messages. The survey company obtained written informed consent from the respondents on our behalf. The questionnaire survey was anonymized, did not retrieve personal information, did not use samples taken from human bodies, and assumed no psychological distress of the respondents. The surveys were approved by the ethics committee of the Central Research Institute of Electric Power Industry in Japan.
The responses were collected on January 29 and 30, 2020, prior to start of the COVID-19 pandemic in Japan. Although the first case of COVID-19 was already reported on January 15, 2020, the number of cases was limited and the effects of the pandemic on this experiment were negligible during the survey term. All the respondents were over 20 years old and living in Japan. Responses were collected from an equal number of men and women. To extract only valid samples, we set two conditions that excluded unreliable samples. One condition ensures that number of children who are living with the respondents or working in paid jobs is smaller than the number of the respondents’ children. The other condition ensures that the respondents’ own income is smaller than the household income. The total number of valid samples was 3,242 and the sex ratio was 99.0, which is higher than that in the general population in Japan of 94.8 in 2019 [44 ].
Fig 1 shows the distribution of the respondents by age and sex. The average ages were 51.3 years for men and 41.9 years for women, resulting in an overall average age of 46.6 years (median of 46 years). A greater number of younger women were included in the samples than men. Because the estimated median age of the population of Japan in 2015 is 46.4 [45 ], the samples were similar to the population in terms of age.

Komatsu H., Kubota H, & Tanaka N. (2023). Nudging attitudes toward IT innovations by information provision that serves as a reminder of familial support. PLOS ONE, 18(2), e0282077.

Publication 2023

Age Groups Child COVID 19 Electricity Ethics Committees, Research Households Human Body Multiple Endocrine Neoplasia Type 2b Pandemics Psychological Distress Woman Youth

Characterizing Liver Disease in Crohn's Patients

Patients were included if they were diagnosed with CD by a gastroenterologist at the Washington University IBD Center and had undergone MRE examination with multi-echo sequences to generate PDFF measurements. Patients were excluded if they had a confounding IBD diagnosis (ie indeterminate colitis, ulcerative colitis, microscopic colitis) or another etiology of their liver disease. Specifically, those with greater than moderate alcohol use per AASLD^{17 (link)} and EASL^{18 (link)} guidelines (>3 standard drinks/day in men or >2 standard drinks/day in women), or a diagnosis of alcohol use disorder, chronic viral hepatitis, autoimmune liver disease, or other toxic-metabolic liver diseases (hemochromatosis, α-1 antitrypsin deficiency) were excluded. Patients with severe malnutrition, glucocorticoid use, methotrexate use, and baseline elevated liver enzymes were not excluded so that they could be characterized in the context of this population.

George A.T., Glover M., Alayo Q., Zulfiqar M., Ludwig D.R., Ciorba M.A., McHenry S, & Deepak P. (2023). Nonalcoholic Fatty Liver Disease Is a Risk Factor for Thiopurine Hepatotoxicity in Crohn’s Disease. Crohn's & Colitis 360, 5(1), otad005.

Publication 2023

Alcohol Use Disorder alpha 1-Antitrypsin Deficiency Autoimmune Diseases Colitis Colitis, Microscopic Diagnosis ECHO protocol Enzymes Gastroenterologist Glucocorticoids Hemochromatosis Hepatitis, Chronic Hepatobiliary Disorder Liver Liver Diseases Malnutrition Methotrexate Multiple Endocrine Neoplasia Type 2b Patients Ulcerative Colitis Woman

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More about "Multiple Endocrine Neoplasia Type 2b"

Multiple Endocrine Neoplasia Type 2b (MEN2b) is a rare, inherited disorder characterized by the development of tumors in multiple endocrine glands.
This complex condition, also known as MEN2B or Sipple syndrome, is caused by genetic mutations that lead to the uncontrolled growth of cells, resulting in the formation of tumors in the thyroid, adrenal glands, and other endocrine tissues.
Patients with MEN2b may experience a variety of symptoms, including thyroid nodules, pheochromocytoma (a type of adrenal gland tumor), and mucosal neuromas (growths on the lips, tongue, and other mucous membranes).
Early diagnosis and appropriate management are crucial for improving patient outcomes and reducing the risk of complications.
The PubCommpare.ai platform can revolutionize research on MEN2b by helping researchers identify the best protocols from literature, preprints, and patents.
This AI-driven platform enables optimized and reproducible research on this complex condition, empowering researchers to discover the most effective protocols and enhance their studies.
In addition to MEN2b, researchers may also encounter related terms and concepts, such as Man alpha(1-3)-Man binding lectin GNA, which is a type of lectin that binds to specific carbohydrate structures, and DC-SIGN/Fc and DC-SIGNR/Fc, which are fusion proteins involved in immune system processes.
Tools like Stata 15, Stata 14, SAS 9.4, and GBlocks (synthetic gene fragments) can also be useful in analyzing and manipulating data related to MEN2b and other endocrine disorders.
By leveraging the insights and capabilities provided by PubCommpare.ai and related tools and concepts, researchers can gain a deeper understanding of MEN2b, optimize their research protocols, and ultimately improve the diagnosis, management, and treatment of this rare but significant condition.