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> Disorders > Neoplastic Process > Spinal Neoplasms

Spinal Neoplasms

Spinal Neoplasms: Abnormal growths or tumors that develop within the spinal cord or vertebral column.
These can be benign or malignant, primary or metastatic, and can affect the structure and function of the spine.
Accurate diagnosis and effective treatment planning are critical for managing spinal neoplasms and optimizing patient outcomes.
PubCompare.ai offers a powerful AI-driven platform to explore the latest research, protocols, and products for spinal neosplasms, supporting data-driven decision making in this important field.

Most cited protocols related to «Spinal Neoplasms»

1
Childhood Cancer Cases and Exposures
Cited 5 times
This study includes children from the Air Pollution and Childhood Cancers (APCC) study previously described [36 (link)]. Childhood cancer cases aged 5 years or younger at diagnosis were identified from the California Cancer Registry from 1988–2013. This analysis was restricted to young children as we hypothesized that pregnancy exposures are likely to be more relevant to the etiology of cancers diagnosed in early childhood. Approximately 89% of cases were successfully matched to their birth certificate by first and last name, date of birth, and when available, social security number. It is likely that children we were unable to match were those who moved to California after birth but before the age of 6 years [37 (link)]. Controls were frequency-matched by year of birth to all childhood cancer cases during the study period (20:1 matching rate) and randomly selected from all California birth certificates. The rationale for choosing a 20:1 ratio was to ensure that in the APCC study, a study of environmental exposures, there would be sufficient controls selected who resided in rural areas. Selection criteria for controls consisted of absence of a cancer diagnosis before 6 years of age in California. Also, potential control children were excluded if they died of any cause prior to age 6 (n=1,792). We also excluded children that were missing sex (n=3), births that were likely not viable (gestational age <20 weeks and/or birthweight <500g) (n=169), and children diagnosed with Down syndrome (n=151). The latter was done because Down syndrome is a strong risk factor for childhood cancer [3 (link)] and potentially related to pregnancy-related characteristics, including maternal obesity [38 (link)]. Additionally, mothers who had extreme or implausible BMI values (<17 kg/m2 or > 45 kg/m2) and gestational weight gain values (< −2 kg or >32 kg) were excluded. Only cancer types with at least 5 exposed cases with respect to pre-pregnancy diabetes were considered for inclusion in our study. AML was also included since ALL and AML are thought to have distinct etiologies. The final sample included 11,149 cases and 270,147 controls. We examined the childhood cancer types classified according to their respective International Classification of Childhood Cancer, 3rd edition (ICCC-3) codes [39 (link)]: 5,034 leukemias (codes 011–015) of which 4,101 were ALL (code 011) and 706 were AML (code 012), 990 astrocytomas (code 032), 709 intracranial and intraspinal embryonal brain tumors (code 033), 445 germ cell tumors (code 101–105), 337 hepatoblastomas (code 071), 1,378 neuroblastomas (code 041), 741 retinoblastomas (code 050), 463 rhabdomyosarcomas (code 091), and 1,052 Wilms’ tumors (code 061). Our study used de-identified records so we were not required to obtain informed consent. The institutional review boards of University of California Los Angeles and the Committee for the Protection of Human Subjects approved this study.
Contreras Z.A., Ritz B., Virk J., Cockburn M, & Heck J.E. (2016). Maternal pre-pregnancy and gestational diabetes, obesity, gestational weight gain, and risk of cancer in young children: a population-based study in California. Cancer causes & control : CCC, 27(10), 1273-1285.
Publication 2016
Air Pollution Astrocytoma Birth Weight Brain Child Childbirth Down Syndrome Embryo Environmental Exposure Ethics Committees, Research Factor IX Complex Gestational Age Hepatoblastoma Leukemia Malignant Neoplasms Mothers Nephroblastoma Neuroblastoma Pregnancy Pregnancy in Diabetics Retinoblastoma Rhabdomyosarcoma Spinal Neoplasms States, Prediabetic Tumor, Germ Cell Youth
2
Phenotypic Characterization of NF1 Codon 1809 Missense Mutations
Cited 5 times
Phenotypic data of all individuals carrying an NF1 constitutional missense mutation affecting codon 1809, as provided by the referring physicians using a standardized phenotypic checklist (Supp. Fig. S1), were reviewed. Initial results on 67 probands and 17 relatives from UAB were reported at the 2013 American College of Medical Genetics meeting [Rojnueangnit et al., 2013]. This initial study was expanded to include 31 additional probands and 21 relatives (from UAB and collaborating centers) and refined by requesting referring physicians to (i) verify whether the information in the originally submitted checklist was accurate and (ii) provide an update on their patient(s) if additional information had become available. The phenotypic data documented in the standardized phenotypic checklist include: age; sex; ethnicity; height; head circumference; NIH criteria including CALMs, freckling, cutaneous, subcutaneous, plexiform and spinal neurofibromas, optic gliomas, Lisch nodules, osseous lesion, and inheritance (familial, sporadic); Noonan syndrome features including short stature, apparently low set ears, hypertelorism, midface hypoplasia, webbed neck, and PS; cardiovascular defect (hypertension, pulmonic, aortic or renal artery stenosis, Moyamoya, ASD, or VSD); development (normal, abnormal, ADD, ADHD, learning disability, autism, speech delay, pervasive developmental delay, IQ) and education; presence/absence of other neoplasms. The UAB cohort comprises 111 individuals (86 probands and 25 relatives). In addition, 25 individuals (12 probands and 13 relatives) from four other centers were included: three Belgian families (six affected individuals) referred to the Medical Genetics Laboratory at the University Ghent, Belgium (UG), one Spanish family (three affected individuals) referred to the Catalan Institute of Oncology, Barcelona, Spain (BARC), four Spanish families (11 affected individuals) referred to the genetic department of the “Hospital Universitario Ramon y Cajal”, Madrid, Spain (MADR) and four UK probands (three familial with genetic and full clinical examination available on four individuals and one proven sporadic individual) evaluated at the Institute of Medical Genetics, University Hospital of Wales, UK (CARD) were included.
The data for any given sign/symptom reflect the number of patients for whom we received information, that is, after exclusion of those with entry “unknown” or “Not Specified.” Screening for Lisch nodules was not routinely performed in most patients. None of the patients presented with ophthalmological problems indicative of a symptomatic OPG, but an MRI to exclude presence of an asymptomatic OPG was not routinely performed, except when stated. Similarly, imaging or whole body MRI was not available in patients without signs or symptoms indicative of internal or spinal tumors.
A patient was classified as having short stature when height was below or equal to the 3rd percentile (PC), using the World Health Organization (WHO) growth curve for age less than 2 years, and the Center for Disease Control (CDC) growth curve for age above 2 years in Caucasian and African‐American ethnicity. For the Spanish individuals, Spaniards’ growth charts were used as provided at http://www.webpediatrica.com/endocrinoped/antropometria.php. As no specific growth curves are available for the Hispanic and Asian populations, but average height is lower than in the Caucasian or African‐American population [Hur et al., 2008; Chen and Chang, 2010; de Wilde et al., 2014], we conservatively excluded Hispanic or Asian patients as having short or normal stature. We still calculated the PC values using the WHO or CDC growth curves and these values are provided between square brackets in the Supp. Table S1. Macrocephaly was defined as the head circumference above the 97th percentile using the WHO curve for age up to 2 years old, and the Gerhard Nellhaus’ curve [Nellhaus, 1968] for age over 2 years old, for all ethnic backgrounds.
A patient was classified as having “NF‐Noonan” when at least two of the following features were present: short stature, low set ears, hypertelorism, midface hypoplasia, webbed neck, or PS.
Rojnueangnit K., Xie J., Gomes A., Sharp A., Callens T., Chen Y., Liu Y., Cochran M., Abbott M., Atkin J., Babovic‐Vuksanovic D., Barnett C.P., Crenshaw M., Bartholomew D.W., Basel L., Bellus G., Ben‐Shachar S., Bialer M.G., Bick D., Blumberg B., Cortes F., David K.L., Destree A., Duat‐Rodriguez A., Earl D., Escobar L., Eswara M., Ezquieta B., Frayling I.M., Frydman M., Gardner K., Gripp K.W., Hernández‐Chico C., Heyrman K., Ibrahim J., Janssens S., Keena B.A., Llano‐Rivas I., Leppig K., McDonald M., Misra V.K., Mulbury J., Narayanan V., Orenstein N., Galvin‐Parton P., Pedro H., Pivnick E.K., Powell C.M., Randolph L., Raskin S., Rosell J., Rubin K., Seashore M., Schaaf C.P., Scheuerle A., Schultz M., Schorry E., Schnur R., Siqveland E., Tkachuk A., Tonsgard J., Upadhyaya M., Verma I.C., Wallace S., Williams C., Zackai E., Zonana J., Lazaro C., Claes K., Korf B., Martin Y., Legius E, & Messiaen L. (2015). High Incidence of Noonan Syndrome Features Including Short Stature and Pulmonic Stenosis in Patients carrying NF1 Missense Mutations Affecting p.Arg1809: Genotype–Phenotype Correlation. Human Mutation, 36(11), 1052-1063.
Publication 2015
African American Aorta Asian Americans Autistic Disorder Body Height Bones Cardiovascular System Caucasoid Races Codon Disorder, Attention Deficit-Hyperactivity Dwarfism Ear Ethnicity Head High Blood Pressures Hispanic or Latino Hispanics Human Body Learning Disabilities Lung Macrocephaly Missense Mutation Moyamoya Disease Neck Neoplasms Neurofibromatoses Noonan Syndrome Optic Nerve Glioma Patients Pattern, Inheritance Phenotype Physical Examination Physicians Renal Artery Stenosis Reproduction Signs and Symptoms Skin Speech Delay Spinal Neoplasms
3
Lumbar Degeneration Treated with OLIF and Posterior Fusion
Cited 3 times
We evaluated 35 patients at our university hospital between June 2012 and February 2012. Patients were diagnosed with lumbar degeneration spondylolisthesis and spinal stenosis, degenerated kyphoscoliosis, and discogenic low back pain on X-ray and magnetic resonance imaging (MRI), myelography, and computed tomography after myelography (CTM). Patients who had previously undergone spinal surgery were included. We excluded spinal tumor, infection, and acute vertebral fractures of the thoracic and lumbar spine. Diagnosis of spondylolisthesis and inclusion criteria for fusion surgery were 1) more than 10% slip of the vertebra in a neutral position or 2) more than 5 mm of translation between flexion and extension positions on radiographic evaluation. Diagnosis of discogenic low back pain was determined by pain provocation by discography and pain relief after discoblock using lidocaine. When pain was provoked during the discography and decreased after the discoblock, we confirmed a diagnosis of discogenic low back pain. For diagnosis of degenerated kyphoscoliosis and indication for surgery, both more than a 40° Cobb's angle on the coronal plane and less than 10° of lordosis on the sagittal plane of the lumbar spine were used as inclusion criteria. Informed consent was obtained from each of the participants. Bone mineral density (BMD) of the lumbar spine was examined before surgery. Details of the patients' backgrounds are shown in Table 1.
All patients initially underwent OLIF (Medtronic OLIF25) surgery. A cage (Clydesdale Spinal System, Medtronic, Minneapolis, MN, USA) filled with bone graft from the iliac bone was used in this study. Subsequently, posterior fixation was utilized in all patients. Open pedicle screws, percutaneous pedicle screws, or cortical bone trajectory screws (Medtronic) were used in all patients. Some patients underwent posterior decompression, while others did not. OLIF fusion from 1 to 4 levels and posterior fusion from 1 to 8 levels was performed (Figs. 1 and 2).
Ohtori S., Orita S., Yamauchi K., Eguchi Y., Ochiai N., Kishida S., Kuniyoshi K., Aoki Y., Nakamura J., Ishikawa T., Miyagi M., Kamoda H., Suzuki M., Kubota G., Sakuma Y., Oikawa Y., Inage K., Sainoh T., Sato J., Fujimoto K., Shiga Y., Abe K., Toyone T., Inoue G, & Takahashi K. (2015). Mini-Open Anterior Retroperitoneal Lumbar Interbody Fusion: Oblique Lateral Interbody Fusion for Lumbar Spinal Degeneration Disease. Yonsei Medical Journal, 56(4), 1051-1059.
Publication 2015
Bone Density Bone Screws Bone Transplantation Cortex, Cerebral Decompression Diagnosis Figs Ilium Infection Inpatient Lidocaine Lordosis Low Back Pain Lumbar Region Myelography Operative Surgical Procedures Pain Patients Pedicle Screws Spinal Fractures Spinal Neoplasms Spinal Stenosis Spondylolisthesis Vertebra Vertebrae, Lumbar X-Ray Computed Tomography X-Rays, Diagnostic
4
Multidisciplinary Approach to Manage Metastatic Spinal Tumors
Cited 2 times
All patients initially diagnosed with metastatic spinal tumors using computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography-CT (PET-CT), or bone scintigraphy are reviewed monthly by radiologists. Similarly, all images used for diagnosis are also reviewed by spine surgeons. The instability of the spine is evaluated using the spinal instability neoplastic score (SINS8 )) of the metastasized vertebra. Spinal instability neoplastic score (SINS) use a combined score of six variables, including lesion location, pain, and degree of vertebral body destruction. A score of less than 6 of a possible 18 points indicates stability, whereas scores of 7 to 12 and more than 13 indicate imminent instability and instability, respectively (Table 1).
For each of the patients reviewed on a monthly basis, those with a SINS > 7 (imminent instability) are reviewed during the liaison conference call to discuss possible treatments.
During these conference calls, the primary oncologists regularly review images of patients who do not require immediate surgery or radiotherapy, prioritized based on risk factors. In this way, the radiologist's interpretation of each image is reviewed by the orthopedic spine surgeon on a regular basis, and metastatic progression can be detected early. The sequence of events wherein the spine surgeon reviews patient images selected by the radiologist is an important aspect of this treatment method. In addition, spine surgeons, radiologists, and physicians are in close contact to prevent serious SREs in advance, a process that is very important and effective.
Nakanishi K., Uchino K., Watanabe S., Iba H, & Hasegawa T. (2020). Liaison Treatment for Metastatic Spinal Tumors. Spine Surgery and Related Research, 4(3), 223-228.
Publication 2020
Bones Conferences Diagnosis Disease Progression Oncologists Operative Surgical Procedures Orthopedic Surgeons Pain Patients Physicians Radiologist Radionuclide Imaging Radiotherapy Scan, CT PET Spinal Neoplasms Surgeons Therapeutics Vertebra Vertebral Body Vertebral Column X-Ray Computed Tomography
5
Lumbar Disc Degeneration Phenotypes
Cited 2 times
The study was approved by the Ethics Committee of the First Affiliated Hospital of Guangxi Medical University. All the experimental protocol and the methods were carried out in accordance with the relevant guidelines and regulations, and complied with the principles of the Declaration of Helsinki. Written informed consent was achieved from each participant.
This study participant including 454 patients with LDD and 485 controls were recruited from Spine Surgery and Physical Examination Center, the First Affiliated Hospital of Guangxi Medical University. The control group was composed of 252 females and 233 males, and the case group was composed of 259 females and 195 males. All patients were diagnosed with LDD based on clinical examinations and Magnetic Resonance Imaging (MRI). Clinical examinations were performed by one attending spine surgeon. MRI images were obtained using a 1.5-T magnetic resonance imaging Achieva scanner (Philips Medical Systems; Best, the Netherlands) with Nova Dual gradients. The following inclusion criteria were applied: (1) low back pain as the main symptom for at least 3 months; (2) MRI shows degenerative changes in lumbar spine; (3) no previous spinal surgery or other treatment that would deform the lumbar spine. Evaluation of the characteristics of the phenotypes based on MRI was performed by two independent radiologists. Any dispute between the two radiologists was resolved by a senior radiologist. According to MRI phenotypes36 (link), the patients with LDD were further divided into three different mutually exclusive subgroups based on as follows: subgroup 1 included 266 patients affected by lumbar disc herniation; subgroup 2 included 105 patients affected by lumbar spinal stenosis and subgroup 3 included 83 patients affected by lumbar spondylolisthesis (Fig. 3). The exclusion criteria were applied: (1) a history of clinician-diagnosed low back pain at least six months’ duration that was present more than half the days of the month; (2) spine deformity; (3) the history of intraspinal tumor, trauma, inflammatory disease and rheumatoid arthritis; (4) previous spinal surgery; (5) MRI phenotype of one patient fit into more than one subgroup. To be eligible for control group, the subjects had no history of low back pain, and were screened by a 1.5-T lumbar spine MRI scan. Disc degeneration were identified in the MRI images and graded according to the modified Pfirrmann grading system39 (link). The subjects with Pfirrmann’s Grade 1 were included in control group. Furthermore, we collected degenerative disc tissues (n = 34) and normal disc tissues (n = 21) from patients with lumbar disc herniation (subgroup 1) and patients with traumatic lumbar vertebral fracture, respectively. Patients with traumatic lumbar fracture had no history of low back pain before surgery and MRI evaluation showed no significant disc degeneration. According to Schneiderman’s classification40 (link), Grade 1 was in 19 patients and Grade 2 was in 2 patients. These samples were used to evaluate VDR expression via immunohistochemistry (IHC).

Classification of patients into subgroups by MRI imaging. (A) Subgroup 1: patients with lumbar disc herniation; white arrow indicates L4/5 herniated disk bulges out toward the spinal canal. (B) Subgroup 2: patients with lumbar spinal stenosis; white arrows indicate L3-4 level spinal stenosis caused by degenerative thickening of the ligamentum flavum. (C) Subgroup 3: patients with lumbar spondylolisthesis; white arrow indicates subluxation of L5 vertebral body relative to S1 vertebral body.

Yang Q., Liu Y., Guan Y., Zhan X., Xiao Z., Jiang H, & Wei Q. (2019). Vitamin D Receptor gene polymorphisms and plasma levels are associated with lumbar disc degeneration. Scientific Reports, 9, 7829.
Publication 2019
Congenital Abnormality Ethics Committees, Clinical Females Fracture, Bone Immunohistochemistry Inflammation Intervertebral Disc Degeneration Intervertebral Disk Displacement Joint Subluxations Ligaments, Flaval Low Back Pain Lumbar Region Males Operative Surgical Procedures Patients Phenotype Physical Examination Radiologist Rheumatoid Arthritis Spinal Canal Spinal Fractures Spinal Neoplasms Spinal Stenosis Spondylolisthesis Surgeons Tissues Vertebrae, Lumbar Vertebral Body Vertebral Column Wounds and Injuries

Most recents protocols related to «Spinal Neoplasms»

1
Retrospective Study of Cervical Spondylosis Surgery
This was a retrospective study and was approved by the Ethical Committee of our hospital. We reviewed cervical spondylosis patients undergoing surgery in our hospital between January 2014 and December 2021 in our orthopedic department. The basic information of patients was inquired according to the case system. The disease time was determined according to the patient's complaint in the case system. In this work, the inclusion criteria were as follows: [1 (link)] diagnosis of cervical spondylosis; [2 (link)] patients with preoperative cervical CT and X-ray within 1 week before surgery; and [3 (link)] accept cervical surgery at our orthopedic department. The exclusion criteria were as follows: [1 (link)] patients with spine infection, spine tumor, spine trauma and metabolic bone disease; [2 (link)] merged cervical spine posterior longitudinal ligament ossification or multiple osteosclerosis; [3 (link)] long-term use of hormones or combined with immune diseases; [4 (link)] patient with nervous system disorders such as demyelinating disease; [5 (link)] a history of previous spinal surgery; [6 (link)] diagnosed with osteoporosis and treated with medication; and [7 (link)] incomplete radiologic data.
Wang Z., Zhong Z., Feng H., Mei J., Feng X., Wang B, & Sun L. (2023). The impact of disease time, cervical alignment and range of motion on cervical vertebral Hounsfield unit value in surgery patients with cervical spondylosis. Journal of Orthopaedic Surgery and Research, 18, 187.
Publication 2023
Cervical Vertebrae Demyelinating Diseases Hormones Immune System Diseases Infection Metabolic Bone Disease Neck Nervous System Disorder Operative Surgical Procedures Orthopedic Surgical Procedures Ossification of Posterior Longitudinal Ligament Osteoporosis Osteosclerosis Patients Pharmaceutical Preparations Radiography Spinal Injuries Spinal Neoplasms Spondylosis, Cervical Vertebral Column
2
Long-Fusion Surgery for Elderly Patients with ASD
The study protocol was approved by the institutional review board at each site. Informed consent was obtained from all patients. We retrospectively documented the data of ASD patients in two hospitals from January 2018 to December 2019, aiming to have a minimum follow-up of 24 months. All of those patients had undergone the procedure of long-fusion (≥ 5 vertebras) with instrumentations by posterior-only approach.
General inclusion criteria for this study were as follows:

Age ≥ 45 years;

Those radiographic parameters met the criteria at least one of the followings: a, coronal curvature ≥ 20°; b, SVA ≥ 5 cm; c, PT ≥ 25°; d, TK ≥ 60° [16 (link), 17 (link)].

The research data before and after surgery, including demographics, surgical and radiographic parameters, were integrated.

The follow-up duration ≥ 24 months.

Those having 1) prior spinal surgeries, 2) history of spinal tumor, 3) history of spinal infection such as tuberculosis, 4) ankylosing spondylitis, 5) any hip disorders, or 6) the differences between two lower extremities ≥ 2 cm were excluded.
In this current study, proximal junctional failure (PJF) was defined as fractures or subluxations happening in the UIV and/or UIV + 1; pedicle screw loosening, dislodgment, or even pullout from the UIV [18 (link)]. Demographics (age, gender, and BMI) and surgical data involving UIV, lower instrumented vertebra (LIV), and fixed segments (FS) were reviewed and documented. Postoperatively, follow-up time and PJF-free survival time after surgery were documented. Radiographs at the pre-operation, the immediate post-operation, and the final follow-up were collected.
Zhang Z., Chen S., Jia S., Chen R., Li N, & Meng C. (2023). Association of spinopelvic index with proximal junctional failure developing in adult spinal deformity after surgical treatment: an observational study. BMC Musculoskeletal Disorders, 24, 180.
Publication 2023
Ankylosing Spondylitis Ethics Committees, Research Fracture, Bone Gender Infection Joint Subluxations Lower Extremity Patients Pedicle Screws Spinal Neoplasms Tuberculosis Vertebra X-Rays, Diagnostic
3
Surgical treatment for cervical radiculopathy
Two-hundred and two participants were consecutively recruited at four neurosurgery/neuro-orthopaedic clinics in Sweden between 2009 and 201212 (link),13 (link), of which 201 underwent surgery (mean age 50; SD 8.4 years, 52% men, neck pain median duration 14 months; arm pain median duration 12 months; IQR 16). The inclusion criteria were: age 18–70 years, persistent radiculopathy symptoms for at least two months, clinical findings of nerve root compression based on examination by a neurosurgeon/neuro-orthopaedic surgeon and compatible with verified cervical disc disease determined by magnetic resonance imaging, and undergoing surgery for CR by either anterior approach (ACDF) or posterior approach with foraminotomy/laminectomy at one to three segmental levels. The exclusion criteria were: myelopathy, previous fracture or luxation of the cervical column, malignancy or spinal tumour, spinal infection, previous surgery in the cervical column, systematic disease or trauma that contraindicated either the rehabilitation programme or the measurements, diagnosis of a severe psychiatric disorder (such as schizophrenia or psychosis), known drug abuse and lack of familiarity with the Swedish language (unable to understand and answer the questionnaires). Of the 201 participants who underwent surgery, 163 were operated on with ACDF using standard cages (i.e. filled with bone substitute or autologous bone collected during decompression; no iliac crest graft was taken) at the clinic where the participant was included. In most cases of multilevel surgery, an anterior plate was added to achieve primary stability. Thirty-eight patients underwent posterior foraminotomy, with or without laminectomy (without fusion). Eight participants did not fulfil the clinical neurological examination at baseline and were excluded from this secondary analysis of outcomes. Thus, the present cohort consisted of 193 participants (Table 1). A total of 153 (79% response rate) and 135 (70% response rate) participants completed the clinical examination at one- and two-year follow-up (Fig. 1). Of the participants attending one-year follow-up, 83 (46%) were men and mean age was 50 (SD 8.2). At the two-year follow-up, 72 (53%) were men and mean age was 50 (SD 8.3). There was no difference in background variables or preoperative neurological outcomes between the patients who attended the neurological clinical examination at follow-up and those who were lost to follow-up (p > 0.194). Patients attending clinical examination at follow-up scored NDI mean value 21 (SD 16.7) at one-year follow-up, and 23 (SD 18.3) at two-year follow-up. There was also no difference in background variables or neurological outcomes at baseline between participants randomized to SPT or SA (p > 0.08) (Table 1).

Background variables for participants with cervical radiculopathy who underwent surgery and postoperative rehabilitation and were included in the secondary analysis of postoperative neurological outcomes.

NTotalSPT (N = 97)SA (N = 96)
Age, mean (SD)19350 (8.4)50 (8.3)50 (8.6)
Sex male, n (%)193100 (52)48 (50)52 (54)
Anterior surgery, n (%)193155 (80)73 (75)82 (85)
NDI %, mean (SD)18443 (14.9)42 (14.5)44 (15.4)
Neck pain mm VAS, mean (SD)18856 (24.3)55 (24.9)57 (23.8)
Arm pain mm VAS, mean (SD)18550 (28.0)52 (26.5)48 (29.5)
Neurological impairment prick touch, n (%)193154 (80)78 (80)76 (80)
Neurological impairment light touch, n (%)193138 (72)70 (72)68 (71)
Neurological impairment motor function, n (%)191150 (79)80 (83)70 (74)
Neurological impairment arm reflex, n (%)186109 (59)50 (53)59 (64)
Positive Spurling test, n (%)14291 (64)49 (67)42 (61)

Results are presented with mean value and standard deviation (SD) or number (n) and percentage (%).

Flow chart of participants included in the analyses of secondary neurological outcomes.

Peolsson A., Löfgren H., Dedering Å., Kristedal M., Öberg B., Zsigmond P, & Wibault J. (2023). Neurological outcomes after surgery and postoperative rehabilitation for cervical radiculopathy due to disc disease: a 2-year-follow-up of a randomized clinical trial. Scientific Reports, 13, 3830.
Publication 2023
Bones Bone Substitutes Cervix Diseases Decompression Diagnosis Diagnosis, Psychiatric Drug Abuse Foraminotomy Fracture, Bone Grafts Iliac Crest Infection Laminectomy Light Males Malignant Neoplasms Mental Disorders Neck Neck Pain Nerve Root Compression Neurologic Examination Neurosurgeon Neurosurgical Procedures Operative Surgical Procedures Orthopedic Surgeons Pain Patients Physical Examination Psychotic Disorders Radiculopathy Radiculopathy, Cervical Reflex Rehabilitation Schizophrenia Signs and Symptoms Spinal Cord Diseases Spinal Neoplasms Touch Visual Analog Pain Scale Wounds and Injuries
4
Dynamic Stabilization vs Fusion in Lumbar Degenerative Diseases
The inclusion and exclusion of studies for the meta-analysis were based on the following criteria. (1) For participants, the study population consisted of patients who satisfied the following criteria: aged 18 years or older; mean follow-up period ≥ 2 years; suffering from lumbar degenerative diseases, including disc herniation, lumbar spinal stenosis, and grade I degenerative spondylolisthesis; and having 1–4 fixed segments in the lumbar. Studies on patients with grade II or higher spondylolisthesis, ankylosis spondylitis, spinal tumor, and severe spinal deformity were excluded. (2) The intervention in the experimental group was dynamic DS. Studies on hybrid dynamic stabilization and other kinds of dynamic stabilization, including Coflex, Wallis, and X-stop systems were excluded. (3) For comparison, the intervention in the control group was instrumented fusion methods, including posterior lumbar interbody fusion, transforaminal lumbar interbody fusion (TLIF), and posterolateral fusion. (4) In terms of outcomes, studies were eligible if they satisfied at least one of the following outcomes: clinical outcomes at final follow-up (VAS and ODI scores, screw loosening and breakage, surgical revision), ASP (ASDeg and ASDis), and radiographical outcomes (postoperative ROM and disc heigh). ASDeg (radiographic ASD) represents radiographic etiologies adjacent to the surgically treated spinal level that involves loss of disc height, disc degeneration, stenosis, instability, or hypertrophic facet arthritis, regardless of the presence of symptoms. [8 (link)] ASDis (symptomatic ASD) is a clinical symptom (manifested as pain, numbness, or the other symptoms caused by nerve compression) that is correlated with radiographic changes in adjacent segments. [2 (link), 8 (link)] The primary outcomes considered were radiographic outcomes and ASP. (5) For study design, randomized controlled trials (RCTs) or comparative studies were eligible. Case series, case reports, reviews, and conference reports were excluded.
Zhou L.P., Zhang R.J., Wang J.Q., Zhang H.Q., Shang J., Gao Y., Jia C.Y., Ding J.Y., Zhang L, & Shen C.L. (2023). Medium and long-term radiographic and clinical outcomes of Dynesys dynamic stabilization versus instrumented fusion for degenerative lumbar spine diseases. BMC Surgery, 23, 46.
Publication 2023
Ankylosis Conferences Congenital Abnormality Degenerative Arthritides Hybrids Intervertebral Disc Degeneration Intervertebral Disk Displacement Lumbar Region Nervousness Operative Surgical Procedures Pain Patients Second Look Surgery Spinal Neoplasms Spinal Stenosis Spondylitis Spondylolisthesis Stenosis X-Rays, Diagnostic
5
Canine Spinal Cord Myelopathy Assessment
A multicenter, retrospective, cross-sectional study was performed at four veterinary animal medical centers. An electronic medical database of Chungbuk National University Veterinary Teaching Hospital, Bon Animal Medical Center, Korea Animal Medical Center, and Soop Daejeon Animal Medical Center were searched to identify canine patients who underwent CT examination between January 2016 and August 2021, including the complete thoracic vertebral column. Decisions for subject inclusion and exclusion were made by one diagnostic imaging expertise. Dogs were included if medical files and CT images were available for review. Exclusion criteria consisted of dogs with a fracture or lysis of the vertebrae, spinal neoplasm (primary or metastatic), prior spinal surgery history (such as hemilaminectomy), poor image quality which was not available for review and under 1 year of age. And to investigate the association of CAP dysplasia and spinal cord myelopathy, neurologically abnormal dogs that underwent both CT and MRI, had thoracic IVDD with neurological deficits of T3-L3 myelopathy were included. Cases in which IVDD occurred only in the lumbar region were excluded. Data collected for client-owned dogs included signalment (breed, age, sex and body weight), reason for CT studies, neurologic signs, and final diagnosis. Breeds were classified by weight: (i) toy breeds, <5 kg; (ii) small breeds, ≥5 kg and <10 kg; (iii) medium breeds, ≥10 kg and <25 kg, (iv) large breeds, ≥25 kg.
Ban J., Park J., Kim H., Yoon K., Oh M., Lee Y., Lee M., Chang J., Kim B., Kim J, & Chang D. (2023). Investigation of canine caudal articular process dysplasia of thoracic vertebrae using computed tomography: Prevalence and characteristics. Frontiers in Veterinary Science, 10, 1066420.
Publication 2023
Animals Breeding Canis familiaris Diagnosis Fracture, Bone Lumbar Region Neurologic Signs Operative Surgical Procedures Patients Spinal Cord Spinal Cord Diseases Spinal Neoplasms Vertebra Vertebrae, Thoracic Vertebral Column

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Pentero 900 by Zeiss
Sourced in Germany
The Pentero 900 is a high-performance microscope system designed for use in neurosurgery, spine surgery, and other complex surgical procedures. It features advanced optical and imaging capabilities to provide detailed, high-resolution visualization of the surgical site.
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Bryan disc by Medtronic
Sourced in United States
The Bryan Disc is a spinal implant device designed for use in cervical disc replacement surgery. It consists of a metal-on-polymer bearing surface that allows for motion preservation in the cervical spine.
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Cyberknife vsi system by Accuray
Sourced in United States
The CyberKnife VSI system is a non-invasive radiation therapy device designed for the treatment of tumors and other medical conditions. The system utilizes a robotic arm to precisely deliver targeted radiation beams to the treatment area, with the goal of minimizing damage to surrounding healthy tissue.
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Nmri nude mice by Janvier Labs
Sourced in France
NMRI nude mice are genetically modified mice that lack a functional immune system, specifically the thymus. This allows for the study of human tumor xenografts and other human disease models without rejection by the host immune system.
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Bga 12s hp gradient system by Bruker
Sourced in Germany
The BGA 12S HP gradient system is a laboratory equipment product from Bruker. It is a high-performance gradient system designed for use in various analytical applications. The core function of this product is to provide precise and controlled gradients for separation and purification processes in a laboratory setting.
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Osirix md by Pixmeo
Sourced in Switzerland
OsiriX MD is a medical imaging software designed for the visualization and analysis of DICOM images. It provides a comprehensive set of tools for viewing, manipulating, and processing medical images from various modalities, including CT, MRI, and PET scans.

More about "Spinal Neoplasms"

Spinal Neoplasms, also known as Spinal Tumors or Vertebral Tumors, are abnormal growths or masses that develop within the spinal cord or vertebral column.
These neoplasms can be benign (non-cancerous) or malignant (cancerous), and can be primary (originating in the spine) or metastatic (spreading from another site in the body).
Accurate diagnosis and effective treatment planning are critical for managing spinal neoplasms and optimizing patient outcomes.
Advances in imaging technologies, such as Brilliance CT Big Bore, 1.5T MRI, and ParaVision 6.0.1, have significantly improved the ability to detect and characterize these tumors.
Surgical intervention, including the use of the Pentero 900 surgical microscope and the CyberKnife VSI system for stereotactic radiosurgery, are often key components of treatment.
The Bryan Disc replacement system is an example of a spinal implant that may be used in some cases.
Preclinical research on spinal neoplasms often utilizes NMRI nude mice and the BGA 12S HP gradient system for MRI imaging.
Computational tools like 3-matic software can also aid in treatment planning and visualization.
By leveraging the power of AI-driven protocol optimization, platforms like PubCompare.ai can help researchers and clinicians explore the latest research, protocols, and products for spinal neoplasms, supporting data-driven decision making in this important field.