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Arterial Occlusion

Arterial Occlusion refers to the partial or complete blockage of an artery, impeding blood flow.
This condition can result from various underlying causes, such as atherosclerosis, thrombosis, or embolism.
Symptoms may include pain, numbness, or discoloration in the affected limb.
Timely diagnosis and appropriate treatment, which may involve medication, angioplasty, or surgery, are crucial to restore blood flow and prevent potentially serious complications, such as tissue damage or limb amputation.
Researchers studying Arterial Occlusion aim to develop more effective diagnostic and therapeutic approaches to improve patient outcomes.
PubCompare.ai's AI-driven platform can help optimie these efforts by enabling researchers to efficiently locate and compare protocols from literature, preprints, and patents, identifying the most effective and accuratle approaches to enhance reproducibility and accuracy in Arterial Occlusion studies.

Most cited protocols related to «Arterial Occlusion»

1
Isolation and Culture of Vascular Smooth Muscle Cells
Under sterile conditions, anaesthetized SD rats were placed in the supine position and their chests were opened. The thoracic aorta was removed and transferred to a culture dish with cold (4°C) DMEM (Figure 1A). After removal of the fat tissue around the artery (Figure 1B), the artery was longitudinally cut and placed in another cell culture dish containing DMEM (Figure 1C). Then, we used a pair of ophthalmic curved tweezers to scrape the intima softly to get rid of endothelial cells (Figure 1D). Later, we did not separate the adventitia or directly cut the artery into small tissue blocks. Two pairs of ophthalmic curved tweezers were used: one to press the artery to fix it and another to separate the media from the artery by pressing and pushing the artery with its blunt back side (Figure 2). After half of the media was removed, the same method was used to get the other half. Then, the media was cut into approximately 1-mm squares and transferred into cell culture plates. The plates were placed in a cell culture chamber for about 4 h to let the small tissue blocks adhere to the plates. DMEM containing 20% FBS was carefully added and the tissue blocks were incubated in the cell culture chamber without disturbance for the first 5 days.
In the traditional tissue explants method, all the steps were similar, and after the fat tissue was removed, the artery was directly cut into small tissue blocks and transferred to cell culture plates without removal of the adventitia.
In the enzyme digestion method, after the fat tissue was removed, the aorta was digested with 1 mg/mL collagenase II and 100 μg/mL elastase at 37°C for 1 h. Later, the cells were pelleted and plated in DMEM with 20% FBS. The next morning, the cells were washed with PBS 3 times and the media were refreshed every 48 h.
The A7r5 cell line has been widely used in vitro to study the physiology and pathophysiology of VSMCs [13 (link),14 (link)]. However, it has lost some VSMCs selectivity and has many differences from primary cultured VSMCs. Therefore, we chose the A7r5 cell line to compare its viability with primary cultured VSMCs.
The VSMCs obtained by the above methods (the new tissue explants method, the traditional tissue explants method, the enzyme digestion method, and A7r5 cell line) were identified through morphology and immunofluorescence detection of SM-actin. The purity of the VSMCs was tested through multiple fluorescent staining with DAPI and SM-actin antibody.
Chi J., Meng L., Pan S., Lin H., Zhai X., Liu L., Zhou C., Jiang C, & Guo H. (2017). Primary Culture of Rat Aortic Vascular Smooth Muscle Cells: A New Method. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 23, 4014-4020.
Publication 2017
Actins Adventitia Aorta Arterial Media Arterial Occlusion Arteries Cell Culture Techniques Cell Lines Cells Chest Collagenase Common Cold Cultural Evolution DAPI Digestion Endothelial Cells Enzymes Fluorescent Antibody Technique Genetic Selection Hyperostosis, Diffuse Idiopathic Skeletal Immunoglobulins Pancreatic Elastase physiology Rattus norvegicus Sterility, Reproductive Thoracic Aorta Tissue, Adipose Tissues Tunica Intima Type II Mucolipidosis
2
Prenatal Hypoxia-Infection Injury Model
All procedures were performed in accordance with the NIH Guide for the Care and Use of Laboratory Animals and with the approval of the Institutional Animal Care and Use Committee at Boston Children’s Hospital. Under isoflurane anesthesia, a laparotomy was performed on pregnant Sprague–Dawley rats on E18 (Figure 1A). For TSHI, uterine arteries were occluded (Figure 1B) and after 60 minutes the clips were removed (Figure 1C). For the combined injury, following 60 minutes of TSHI, 4 μg sterile LPS (LPS 0111:B4, Sigma, St. Louis, MO) mixed with diluted Evans blue dye (Sigma) was injected into each amniotic sac (Figure 1D). For LPS alone, LPS was injected without transient uterine artery occlusion. For sham controls, the laparotomy was performed and uterine horns were exposed for 60 minutes, without artery occlusion or LPS injection. Thus, all dams experienced an equivalent time of laparotomy under anesthesia. Pups were born at term (E22) and matured with their respective dams. Litter size was recorded. Pups were weaned at P21. Pups were weighed at the ages noted, and gender was recorded. Overall, 12 sham, 16 TSHI, 7 LPS and 18 TSHI + LPS dams were used.
Jantzie L.L., Corbett C.J., Berglass J., Firl D.J., Flores J., Mannix R, & Robinson S. (2014). Complex pattern of interaction between in utero hypoxia-ischemia and intra-amniotic inflammation disrupts brain development and motor function. Journal of Neuroinflammation, 11, 131.
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Publication 2014
Amnion Anesthesia Animals, Laboratory Arterial Occlusion Childbirth Clip Dental Occlusion Evans Blue Gender Injuries Institutional Animal Care and Use Committees Isoflurane Laparotomy Rats, Sprague-Dawley Sterility, Reproductive Transients Uterine Arteries Uterine Cornua Uterus
3
Evaluating Efferocytosis in Myocardial Infarction
Briefly, CD36-/-36 (link), LRPfl/fl LysMcre37 (link), and Mertk-/-38 (link) bone marrow-derived mouse macrophages were co-cultivated with primary adult mouse CMs and efferocytosis assessed ex vivo. Parallel assays were performed in which Mertk was reconstituted into cells to test sufficiency. In vivo, Mertk+/+ and Mertk-/- mice and bone marrow chimeras were subjected to myocardial infarction after permanent occlusion of the left anterior descending artery. Subsequently, Mertk expression (mRNA and protein), apoptotic cell accumulation (TUNEL), in situ efferocytosis, infarct size (TTC and collagen staining), inflammatory parameters (chemokine and cytokine mRNA and MΦ accumulation), and ventricular remodeling and cardiac function (echocardiography) were measured. The identification of glycosylated solMER in heart extracts was corroborated by addition of an N-glycanase. Statistical Analysis. Results are presented as means +/- SEM. Differences between multiple groups were compared by analysis of variance as appropriate and as indicated (2-way ANOVA and Bonferroni post-test), and differences between 2 groups were compared by unpaired Student t test (indicated by #). Two way repeated measures ANOVA was used to evaluate the statistical significance of data acquired from the same animal over multiple time points. A p value of < 0.05 was considered to be significant as indicated by * or #. Stated “n” values are biological replicates. Survival distributions were estimated using the Kaplan-Meier method and compared by the log-rank test.
An expanded and detailed Materials & Methods section is available in supplemental Online Data.
Wan E., Yeap X.Y., Dehn S., Terry R., Novak M., Zhang S., Iwata S., Han X., Homma S., Drosatos K., Lomasney J., Engman D.M., Miller S.D., Vaughan D.E., Morrow J.P., Kishore R, & Thorp E.B. (2013). Enhanced Efferocytosis of Apoptotic Cardiomyocytes Through MER Tyrosine Kinase Links Acute Inflammation Resolution to Cardiac Repair After Infarction. Circulation research, 113(8), 10.1161/CIRCRESAHA.113.301198.
Publication 2013
Adult Animals Apoptosis Arterial Occlusion Biological Assay Biopharmaceuticals Bone Marrow c-Mer Tyrosine Kinase Cells Chemokine Chimera Collagen Cytokine Echocardiography glycanase Heart Infarction Inflammation In Situ Nick-End Labeling Macrophage Mus Myocardial Infarction neuro-oncological ventral antigen 2, human Proteins RNA, Messenger Student
4
Comparing Arterial Occlusion Using Cuff Widths
With the subjects supine, in a randomized order, either the wide (Hokanson, SC12, Bellevue, WA; 13.5 cm × 83 cm) or narrow (Kaatsu Master, Sato Sports Plaza, Tokyo Japan; 5 cm × 135 cm) cuffs were applied to the most proximal portion of each leg. The pulse at the ankle (arterial blood flow) was detected using a hand-held bidirectional Doppler probe placed on the posterior tibial artery. This site was chosen because femoral artery blood flow is difficult to measure with cuffs applied. Both auditory and visual signals from the Doppler probe indicated if the pulse was present.
The narrow cuffs were applied with an initial compressive force between 40 and 60 mmHg (Karabulut et al. 2011b (link)). The wide cuffs were applied tightly around the upper thigh; however, the device which inflates the wide cuffs does not allow an initial compressive force to be set. The narrow cuffs were connected to a Kaatsu Master Cuff inflator (Sato Sports Plaza, Tokyo, Japan); the wide cuffs were connected to an E 20 Rapid Cuff Inflator (Hokanson, Bellevue, WA). Both devices adjust cuff pressure automatically and actual cuff pressures were confirmed on the machines’ digital window. The same inflation protocol was used for both types of cuffs. The cuffs were first inflated to 50 mmHg for 30 s and then deflated for 10 s. Cuffs were then inflated to the subject’s SBP for 30 s and then deflated for 10 s. Cuff pressure was then increased incrementally by 40 mmHg (30 s inflation followed by a 10 s deflation) until the arterial flow was no longer detected during inflation. When arterial flow was no longer detected, cuff pressure was decreased in 10 mmHg units until arterial flow was present. Arterial occlusion pressure was recorded to the nearest 10 mmHg as the lowest cuff pressure at which a pulse was not present. This process was repeated with both the wide and narrow cuff devices with 5 min rest allotted between the procedures. Cuff pressures were increased up to but not over 300 mmHg. If subjects still had a detectable pulse at 300 mmHg cuff pressure, arterial occlusion pressure was recorded as “300 + mmHg.” Subjects in which arterial occlusion did not occur with the narrow cuffs were not included in the regression analysis (explained below).
Loenneke J.P., Fahs C.A., Rossow L.M., Sherk V.D., Thiebaud R.S., Abe T., Bemben D.A, & Bemben M.G. (2011). Effects of cuff width on arterial occlusion: implications for blood flow restricted exercise. European journal of applied physiology, 112(8), 2903-2912.
Publication 2011
Ankle ARID1A protein, human Arterial Occlusion Arteries Auditory Perception Blood Circulation Dental Occlusion Femoral Artery Fingers Medical Devices Pressure Pulse Pressure Pulse Rate Thigh Tibial Arteries, Posterior
5
Randomized Endovascular Therapy versus Intravenous t-PA for Acute Stroke
Participants were randomly assigned in a 2:1 ratio to endovascular therapy or intravenous t-PA alone with the use of an Internet-based, computerized algorithm of minimization and the biased-coin method, which accounted for two factors: clinical center and baseline NIHSS strata (scores of 8 to 19 vs. ≥20).23 We calculated that a sample of 900 patients would provide an effect size of 10 percentage points (the absolute difference between the endovascular-therapy and intravenous t-PA groups in the proportion of participants with a modified Rankin score of ≤2 at 90 days), assuming that 40% of the patients had a good outcome in the intravenous t-PA group, as noted in those patients in the NINDS rt-PA Stroke Study who had age and baseline stroke severity similar to the eligibility criteria for the IMS III trial1 (link),12 (link); type 1 and type 2 error probabilities of 0.05 (two-sided) and 0.20, respectively; an inflation factor of 1.03 to account for a noncompliance rate of approximately 2%; and the O’Brien and Fleming–type alpha-spending function24 (link) for three interim efficacy analyses.
The prespecified criterion for futility was based on conditional power of less than 20% under the alternative hypothesis. The primary efficacy hypothesis was assessed with the use of the Cochran–Mantel–Haenszel test, with adjustment for the dichotomized baseline NIHSS score, and the weights of the Cochran–Mantel–Haenszel test were applied in the estimation of the risk difference.25 At both the interim and the final analyses, an unfavorable outcome (defined as a modified Rankin score of >2) was imputed for participants who had missing data for the primary outcome or for whom data on the primary outcome were obtained outside the specified window. For all analyses of predefined secondary outcomes and subgroup and safety analyses, each test was conducted at a two-sided alpha level of 0.01. Prespecified subgroup analyses included NIHSS strata, time from symptom onset to treatment (intravenous t-PA and endovascular therapy), presence or absence of arterial occlusion on CT angiography at baseline, age, sex, and presence or absence of atrial fibrillation. For the analysis of raw modified Rankin scores, we used the van Elteren test.26
Broderick J.P., Palesch Y.Y., Demchuk A.M., Yeatts S.D., Khatri P., Hill M.D., Jauch E.C., Jovin T.G., Yan B., Silver F.L., von Kummer R., Molina C.A., Demaerschalk B.M., Budzik R., Clark W.M., Zaidat O.O., Malisch T.W., Goyal M., Schonewille W.J., Mazighi M., Engelter S.T., Anderson C., Spilker J., Carrozzella J., Ryckborst K.J., Janis L.S., Martin R.H., Foster L.D, & Tomsick T.A. (2013). Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke. The New England journal of medicine, 368(10), 893-903.
Publication 2013
Alteplase Arterial Occlusion Atrial Fibrillation Cerebrovascular Accident Computed Tomography Angiography Eligibility Determination Patients Safety Therapeutics

Most recents protocols related to «Arterial Occlusion»

1
In Vivo Imaging of MMP Activation in MI
Not available on PMC !

Example 1

We have established the feasibility of in vivo imaging of MMP activation in pigs (Sahul et al. Circ Cardiovasc Imaging 2011, 4:381-391) and dogs (Liu et al. J Nucl Med 2011, 52(3):453-60) post-MI. The data derived in pigs involved surgical occlusion of two marginal branches of the left circumflex artery and resulted in regional activation of MMPs in the inferolateral wall. (Sahul et al. Circ Cardiovasc Imaging 2011, 4:381-391). This surgical model caused significant activation of MMPs in the surgical wound adjacent to both the atria and ventricles of heart, complicating in vivo imaging. The studies in dogs employed percutaneous balloon occlusion of left anterior descending artery, avoided the surgical intervention, and resulted in improved image quality. In these recently published porcine studies with serial SPECT/CT imaging, we demonstrated focal uptake of the MMP-targeted agent 99mTc-RP805 within the infarcted lateral wall, which peaked at ˜2 weeks post injury, and remained elevated at 4 weeks post occlusion. Early MMP activity at 1 week post-MI predicted late post MI ventricular remodeling (FIG. 1).

US11865195B2. Evaluation of presence of and vulnerability to atrial fibrillation and other indications using matrix metalloproteinase-based imaging (2024-01-09). Lantheus Medical Imaging, Inc. [US], Yale University [US]. Inventors: Albert J. Sinusas [US], Joseph G. Akar [US], Richard R. Cesati [US], Heike S. Radeke [US], Stephen B. Haber [US].
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Patent 2024
Arterial Occlusion Atrial Fibrillation Canis familiaris Dental Occlusion Heart Atrium Heart Ventricle Injuries Interstitial Collagenase MMP1 protein, human Operative Surgical Procedures Pigs Single Photon Emission Computed Tomography Computed Tomography Surgical Wound Sus scrofa
2
Adjudication of Cardiovascular Outcomes in WHI
The ascertainment and adjudication of primary and secondary outcomes for WHI have been described in detail previously (21 (link)). In brief, OS study participants were contacted by mail annually to collect self-reported outcomes, as well as updated exposure data (15 (link)). The adjudication of outcomes for all OS participants continued through August 2009, allowing for an average duration of follow-up for OS participants of 12 years (17 (link)). The initial adjudication of outcomes was performed by a physician adjudicator at a local clinical center and consisted of a physician review of hospital discharge summaries, relevant diagnostic tests, and death certificates. Primary and safety outcomes were subsequently confirmed by central adjudication; a review of primary cardiovascular outcomes was performed by the WHI Cardiovascular Central Adjudication Committee (21 (link)).
Outcomes for the current analysis were adjudicated total CVD (fatal and non-fatal) and three major types of CVD: CHD, heart failure, and stroke, occurring within 5 years of baseline. These comprised primary (CHD) or secondary (CVD, heart failure, and stroke) cardiovascular outcomes in the WHI CT and were also ascertained among OS participants; (21 (link)) methods for ascertainment of these outcomes were therefore well documented and consistent across local clinical centers.
Cardiovascular outcomes were defined as in the WHI OS. Non-fatal CVD outcomes were defined as CHD, stroke, heart failure, peripheral vascular disease, angina, coronary artery bypass graft (CABG), coronary revascularization, and pulmonary embolism (21 (link)). Fatal CVD outcomes were defined as death due to cerebrovascular, definite CHD, possible CHD, pulmonary embolism, other cardiovascular, or unknown cardiovascular causes.
The outcome of CHD in WHI OS participants was defined as hospitalized myocardial infarction (MI) (definite or probable) or coronary death (21 (link)). Definite and probable MI events were identified by an algorithm comprising medical history data, electrocardiogram readings, and cardiac enzyme/troponin levels, as available (22 (link)). Silent MI events were not ascertained in OS participants; therefore, silent MI was not considered as an outcome in this analysis. Fatal coronary outcomes comprised out-of-hospital as well as hospitalized deaths: coronary death was identified based on a physician review of medical records and death certificate data and was defined as death consistent with an underlying cause of death of CHD (21 (link)).
Outcome of heart failure was defined as signs and symptoms of heart failure together with one of the following: pulmonary edema on X-ray; ventricular dilation/poor ventricular function; or physician diagnosis and treatment for heart failure. Stroke was defined as rupture or obstruction of the brain arterial system, resulting in rapid neurological deficit persisting for 24 h or more. Stroke outcome comprised stroke, hemorrhagic stroke, or cause of death reported as stroke. Heart failure and stroke not resulting in hospitalization were not considered as WHI outcomes (21 (link)).
Wright C.E., Enquobahrie D.A., Prager S., Painter I., Kooperberg C., Wild R.A., Park K., Sealy-Jefferson S, & Kernic M.A. (2023). Pregnancy loss and risk of incident CVD within 5 years: Findings from the Women's Health Initiative. Frontiers in Cardiovascular Medicine, 10, 1108286.
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Publication 2023
Angina Pectoris Arterial Occlusion Brain Cardiac Death Cardiovascular System Cerebrovascular Accident Congestive Heart Failure Coronary Artery Bypass Surgery Diagnosis Dilatation Electrocardiography Fatal Outcome Heart Hemorrhagic Stroke Hospitalization Myocardial Infarction Patient Discharge Peripheral Vascular Diseases Physicians Pulmonary Edema Pulmonary Embolism Radiography Safety Test, Clinical Enzyme Tests, Diagnostic Troponin Ventricular Function
3
Traumatic Brain Injury in Male Pigs
All procedures on pigs were approved by the Johns Hopkins University Animal Care and Use Committee and by the Animal Care and Use Review Office of the US Army Medical Research and Materiel Command for Award Number W81XWH-19-C-0022 (Fort Detrick, MD). In conducting research using animals, the investigators adhered to the Animal Welfare Act Regulations and other Federal statutes relating to animals and experiments involving animals and the principles set forth in the current version of the Guide for the Care and Use of Laboratory Animals, National Research Council.
Because there can be sex differences in the response to TBI (43 (link), 44 (link)) and TBI in the young and in military personnel is more prevalent in males (45 (link)), the study was conducted in male pigs. A total of 48 pigs weighing 28 ± 2 kg and approximately 3 months of age were used in the overall study. The experimental protocols for the TBI + HS experiment and the TBI alone experiment are delineated in Figure 1. The pigs were sedated with intramuscular injection of Telazol (50 mg/ml tiletamine and 50 mg/ml zolazepam, 4.4 mg/kg each component), ketamine 2.2 mg/kg and xylazine 2.2 mg/kg. Isoflurane (4% in 30% O2) was administered via face mask to produce an anesthetic depth for oral intubation of the trachea. After a surgical plane of anesthesia was achieved, as assessed by the lack of limb withdrawal to hoof pinching and by looseness of muscle tone in the jaw, anesthesia was maintained with 2% isoflurane in approximately 30% O2 with mechanical ventilation of the lungs. The antibiotic Baytril 10 mg/kg (100 mg/ml) was injected intramuscularly. Surgery was conducted using aseptic techniques. Through a 5-cm neck incision, an external jugular vein was isolated by blunt dissection. The vein was ligated and a catheter was advanced toward the heart and secured with another ligature. For arterial catheterization, we chose the axillary artery because occlusion of the carotid artery could limit cerebral blood flow after TBI and catheterization of the femoral artery can limit use of the hindlimb. An incision was made in the axilla, and the axillary artery was isolated, ligated, and cannulated with a flexible polyvinyl catheter that minimized kinking. The arterial and venous catheters were tunneled subcutaneously to the back of the neck, where they exited through a small incision. Pigs were able to bear weight on the forelimb and ambulate on the day after surgery.
Wang J., Shi Y., Cao S., Liu X., Martin L.J., Simoni J., Soltys B.J., Hsia C.J, & Koehler R.C. (2023). Polynitroxylated PEGylated hemoglobin protects pig brain neocortical gray and white matter after traumatic brain injury and hemorrhagic shock. Frontiers in Medical Technology, 5, 1074643.
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Publication 2023
Anesthesia Anesthetics Animals Animals, Laboratory Antibiotics Arterial Occlusion Arteries Asepsis Axilla Axillary Artery Baytril Bears Carotid Arteries Catheterization Catheters Cerebrovascular Circulation Common Carotid Artery Dental Occlusion Dissection Face Femoral Artery Heart Hindlimb Hoof Intramuscular Injection Intubation, Intratracheal Isoflurane Jugular Vein Ketamine Ligature Males Mechanical Ventilation Military Personnel Muscle Tonus Neck Operative Surgical Procedures Pigs Polyvinyls Telazol Tiletamine Upper Extremity Veins Xylazine Zolazepam
4
CTO-PCI Program Implementation and Evaluation
We started a CTO program in our institution in May 2007 with a low case volume during its initial stages increasing trend in patient recruitment with at least 50 procedures a year since 2013. Five workshops over 5 consecutive years with experienced operators were organized in our center as part of training in CTO-PCI and in order to improve local operators’ experience. We had a dedicated operator in our institution for CTOs, although a few procedures were performed by a second operator in the first 100 block of cases. A CTO was defined as the presence of a coronary artery segment obstruction greater than 3 months standing with Thrombolysis in Myocardial Infarction (TIMI) grade 0 flow [10 (link)]. All data were prospectively introduced into a database including all potential angiographic variables previously related to the difficulty of the procedural success such as ostial location for example [11 (link)]. Since the publication of the J-CTO score by Morino et al. [7 (link)] in 2011 derived from Multicenter CTO Registry in Japan [12 (link)] those variables related to the wire crossing time through a CTO in this study were introduced in our database and reviewed and checked retrospectively. The J-CTO score was derived from the analysis of a cohort of 494 CTO-PCIs defining the complexity of the cases in accordance with the guidewire crossing through the CTO segment within 30 min [7 (link)]. Five independent predictors were found: in segment or CTO entry tortuosity more than 45°, calcification, the CTO length ≥ 20 mm, a blunt stump and any reattempted procedure. The score gives one point to each variable, if present, categorizing the level of difficulty of the procedure in easy (J-CTO = 0), intermediate (J-CTO = 1), difficult (J-CTO = 2) and very difficult (J-CTO ≥ 3), respectively. A thorough review of the above-mentioned variables was carried out by two observers working in our cath lab and, in case of any discrepancy the opinion of a third examiner was asked and a final consensus was established. After completing the review, J-CTO variables of 50 randomly selected cases were examined again and the level of concordance between two observers was estimated in order to assess and resolve any possible interobserver bias. Successful angiographic result was defined when recanalization of the occluded artery with final TIMI flow grade III (TIMI III) and residual lesion less than 30% was achieved. All complication such as in-hospital death, peri-procedural myocardial infarction (MI), coronary perforation requiring pericardiocentesis, major vascular complications needing percutaneous or surgical intervention were reported and its incidence was compared between failed and successful procedure groups. Attribution of peri-procedural MI was in accordance with the universal definition of PCI-related MI (type 4a) [13 (link)].
Mohandes M., Moreno C., Rojas S., Doblas V., Fuertes M., Fernández F., Pernigotti A., Guarinos J., Camprubi M, & Bardají A. (2023). J-chronic total occlusion score predictive capacity for percutaneous coronary intervention success of chronic total occlusion: Results from a European single center cohort with progressive experience over time. Cardiology Journal, 30(1), 59-67.
Publication 2023
Amputation Stumps Angiography Arterial Occlusion Blood Vessel Calcinosis Coronary Occlusion Fibrinolytic Agents Heart Myocardial Infarction Operative Surgical Procedures Pericardiocentesis Workshops
5
Cardiovascular Events in AMI Patients
Most of the data were obtained from the medical records at the First Hospital of Jilin University that contained data on the baseline characteristics, biochemical markers, electrocardiogram (ECG) images, coronary angiography, and medications provided during hospitalization. Basic patient information (e.g., age, sex) and past medical history (e.g., smoking history, history of hypertension, hyperlipidemia, diabetes, arrhythmias) were recorded in detail. The history of arrhythmias including previous atrial arrhythmias or ventricular arrhythmias or heart block. We collected information regarding biochemical markers, including blood cardiac troponin-T(cTnT), creatine kinase-MB(CK-MB), brain natriuretic peptide (BNP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG) and indicators of echocardiography, including LV (left ventricle) and LVEF (left ventricular ejection fraction) in 24 h after hospitalization. We classified the patients into the STE and NSTE groups based on their ECG results. STE and NSTE were defined in accordance with the Fourth Universal Definition of Myocardial Infarction (Thygesen et al., 2018 (link)).
The primary clinical endpoint of our study was the occurrence of major adverse cardiovascular events (MACE), including rehospitalization for increased chest pain that did not meet the criteria of AMI, based on ECG results and myocardial injury marker levels, and occurrence of non-fatal MI, heart failure, stroke, heart valve replacement, and all-cause deaths, which included cardiovascular and non-cardiovascular deaths. A diagnosis of MI was made if patients exhibited the dynamic development of cardiac troponin in conjunction with symptoms suggestive of myocardial ischemia. Cardiovascular death was defined as death because of acute coronary syndrome (ACS), cardiac rupture, severe arrhythmias, or refractory severe heart failure. A stroke was defined as an ischemic cerebral infarction caused by thrombotic or embolic occlusions in any major intracranial artery. A diagnosis of heart failure (HF) was established according to the current guidelines of the European Society of Cardiology (ESC) (Ponikowski et al., 2016 (link)).
Chen L., Fan Y., Fang Z, & Liu N. (2023). Long-term outcomes and predictors of patients with ST elevated versus non-ST elevated myocardial infarctions in non-obstructive coronary arteries: a retrospective study in Northern China. PeerJ, 11, e14958.
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Publication 2023
Acute Coronary Syndrome Arterial Occlusion BLOOD Cardiac Arrhythmia Cardiac Rupture Cardiovascular System Cerebral Infarction Cerebrovascular Accident Chest Pain Cholesterol Cholesterol, beta-Lipoprotein Congestive Heart Failure Coronary Angiography Diabetes Mellitus Diagnosis Echocardiography Electrocardiography Europeans Heart Heart Atrium Heart Block Heart Valves Heart Ventricle High Blood Pressures High Density Lipoprotein Cholesterol Hospitalization Hyperlipidemia Injuries Isoenzyme CPK MB Left Ventricles Myocardial Infarction Myocardial Ischemia Myocardium Nesiritide Patient Readmission Patients Pharmaceutical Preparations Triglycerides Troponin Troponin T Ventricular Ejection Fraction

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More about "Arterial Occlusion"

Arterial Occlusion, also known as Artery Blockage or Arterial Obstruction, refers to the partial or complete blockage of an artery, impeding blood flow.
This condition can result from various underlying causes, such as atherosclerosis (buildup of plaque), thrombosis (blood clot formation), or embolism (blockage by a foreign object).
Symptoms may include pain, numbness, or discoloration in the affected limb.
Timely diagnosis and appropriate treatment, which may involve medication, angioplasty (widening the artery), or surgery, are crucial to restore blood flow and prevent potentially serious complications, such as tissue damage or limb amputation.
Researchers studying Arterial Occlusion may utilize tools like EndoPAT 2000 (a non-invasive device to assess endothelial function), Pentobarbital sodium (an anesthetic used in animal studies), TR-100 (a drug to treat peripheral artery disease), and C57BL/6 mice (a common animal model) to develop more effective diagnostic and therapeutic approaches.
They may also employ techniques like 1.5-T MRI system (for imaging), LPS (0111:B4) (a bacterial endotoxin to induce inflammation), Visipaque (a contrast agent), Rhodamine 6G (a fluorescent dye), and Urethane (an anesthetic) to enhance reproducibility and accuracy in their studies.
PubCompare.ai's AI-driven platform can help optimize these efforts by enabling researchers to efficiently locate and compare protocols from literature, preprints, and patents, identifying the most effective and accurate approaches to improve patient outcomes.
By incorporating synonyms, related terms, abbreviations, and key subtopics, this comprehensive overview provides valuable insights into the complex field of Arterial Occlusion research.