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> Disorders > Pathologic Function > Vitreous Hemorrhage

Vitreous Hemorrhage

Vitreous Hemorrhage is a condition where bleeding occurs inside the vitreous humor, the clear, jelly-like substance that fills the eye's interior.
This can obstruct vision and is often a symptom of underlying eye or health conditions.
PubCompare.ai helps researchers optimize their protocols and find the best products from literature, preprints, and patents to accurately and reproducibly study Vitreous Hemorrhage, enhancing the quality and reliability of their research.

Most cited protocols related to «Vitreous Hemorrhage»

1
Cardiovascular Outcomes in Diabetes
The primary composite outcome in the time-to-event analysis was the first occurrence of death from cardiovascular causes, nonfatal (including silent) myocardial infarction, or nonfatal stroke. Prespecified exploratory outcomes included an expanded composite cardiovascular outcome (death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization, or hospitalization for unstable angina pectoris or heart failure), death from any cause, a composite renal and retinal microvascular outcome (nephropathy [defined as the new onset of macroalbuminuria or a doubling of the serum creatinine level and an eGFR of ≤45 ml per minute per 1.73 m2, the need for continuous renal-replacement therapy, or death from renal disease] and retinopathy [defined as the need for retinal photocoagulation or treatment with intravitreal agents, vitreous hemorrhage, or the onset of diabetes-related blindness]), neoplasms, and pancreatitis — all of which were adjudicated in a blinded fashion by an external, independent event-adjudication committee. The definitions that were used for the clinical events and the members of the committee are listed in the Supplementary Appendix.
The glycated hemoglobin level was measured at randomization, at month 3, and then every 6 months thereafter. Other laboratory tests were performed at randomization, at months 6 and 12, and annually thereafter. Prespecified comparisons between groups were performed at 36 months, which was the last annual visit with laboratory testing that was prespecified for the entire trial population, given the minimum follow-up of 42 months.
Marso S.P., Daniels G.H., Brown-Frandsen K., Kristensen P., Mann J.F., Nauck M.A., Nissen S.E., Pocock S., Poulter N.R., Ravn L.S., Steinberg W.M., Stockner M., Zinman B., Bergenstal R.M, & Buse J.B. (2016). Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes. The New England journal of medicine, 375(4), 311-322.
Publication 2016
Angina, Unstable Blindness Cardiovascular System Cerebrovascular Accident Committee Members Congestive Heart Failure Continuous Renal Replacement Therapy Creatinine Diabetes Mellitus EGFR protein, human Heart Hemoglobin, Glycosylated Hospitalization Kidney Kidney Diseases Light Coagulation Myocardial Infarction Neoplasms Pancreatitis PER1 protein, human Retina Retinal Diseases Serum Vitreous Hemorrhage
2
Defining Cardiometabolic Conditions in Diabetics
Hypertension was defined as systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥ 90 mmHg, or a self-reported previous diagnosis of hypertension. Dyslipidemia was defined as total cholesterol ≥ 6.22 mmol/L (240 mg/dL), triglycerides ≥ 2.26 mmol/L (200 mg/dL), LDL ≥ 4.14 mmol/L (160 mg/dL), HDL < 1.04 mmol/L (40 mg/dL), or a self-reported previous diagnosis of hyperlipidemia by a physician, according to the modified National Cholesterol Education Program-Adult Treatment Panel III [27 (link)].
The CVD outcome was defined as a previous diagnosis of coronary heart disease, stroke, or peripheral arterial disease and was recorded in the registration platform [28 (link)].
The estimated glomerular filtration rate (eGFR) was calculated according to the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for “Asian origin” [29 (link)]. The definition of DKD was ACR higher than 30 mg/g or eGFR < 60 mL/min per 1.73 m2, as suggested by the statement from the American Diabetes Association [30 (link)].
Participants without DR were defined as having no abnormalities in fundus photographs; participants with DR included individuals with intraretinal microaneurysms, hemorrhages, venous beading, prominent microvascular abnormalities, neovascularization or vitreous/preretinal hemorrhages in accordance with the Global Diabetic Retinopathy Project Group [31 (link)].
Wan H., Wang Y., Xiang Q., Fang S., Chen Y., Chen C., Zhang W., Zhang H., Xia F., Wang N, & Lu Y. (2020). Associations between abdominal obesity indices and diabetic complications: Chinese visceral adiposity index and neck circumference. Cardiovascular Diabetology, 19, 118.
Publication 2020
Adult Asian Americans Cerebrovascular Accident Cholesterol Congenital Abnormality Diabetes Mellitus Diabetic Retinopathy Diagnosis Dyslipidemias Glomerular Filtration Rate Heart Disease, Coronary Hemorrhage High Blood Pressures Hyperlipidemia Microaneurysm Pathologic Neovascularization Peripheral Vascular Diseases Physicians Pressure, Diastolic Programmed Learning Systolic Pressure Triglycerides Veins Vitreous Hemorrhage
3
Cardiometabolic Comorbidities in Diabetes
Body mass index (BMI) was calculated by weight in kilogram divided by squared height in meter. The WHO criteria for Asians were used to classify BMI into four categories16 : underweight at <18.5 kg/m2, normal weight at 18.5–24.0 kg/m2, overweight at 24.0–28.0 kg/m2 and obesity at >28.0 kg/m2. Hyperglycemia and abnormal lipids were defined as not reaching their treatment goals as recommended by the American Diabetes Association,17 (link) that is, HbA1c≥7% for hyperglycemia, TG≥1.7 mmol/L, LDL-C ≥2.6 mmol/L or HDL-C ≤1 mmol/L in men and HDL-C ≤1.3 mmol/L in women for abnormal lipids. The Cockcroft-Gault equation18 (link) was used to obtain estimated glomerular filtration rate (eGFR) expressed in milliliters per minute per 1.73 m2: eGFR=[(140−age)×weight×1.23×(0.85 if female)/SCr].
DR was evaluated by the bilateral retinal photography and was defined as the presence, if any, of the following lesions: microaneurysms, retinal hemorrhages, soft exudates, hard exudates, or vitreous hemorrhage. DN was defined as persistent albuminuria, progressive reduction in glomerular filtration rate and hypertension judged by clinicians. CHD was defined as having a history of angina with abnormal ECG or on stress test, myocardial infarction, angina coronary artery bypass graft surgery or angioplasty; stroke was defined as non-fatal subarachnoid hemorrhage, intracerebral hemorrhage, or other unspecified intracranial hemorrhage and ischemic stroke.
Luo H.H., Li J., Feng X.F., Sun X.Y., Li J., Yang X, & Fang Z.Z. (2020). Plasma phenylalanine and tyrosine and their interactions with diabetic nephropathy for risk of diabetic retinopathy in type 2 diabetes. BMJ Open Diabetes Research & Care, 8(1), e000877.
Publication 2020
Angina Pectoris Angioplasty Asian Americans Cerebral Hemorrhage Cerebrovascular Accident Coronary Artery Bypass Surgery Diabetes Mellitus Exercise Tests Exudate Glomerular Filtration Rate High Blood Pressures high density lipoprotein-1 Hyperglycemia Index, Body Mass Intracranial Hemorrhage LDL-2 Lipids Lipoproteins, HDL3 Microaneurysm Myocardial Infarction Obesity PER1 protein, human Retina Retinal Hemorrhage Stroke, Ischemic Subarachnoid Hemorrhage Vitreous Hemorrhage Woman
4
Vitreous Fluid and Epiretinal Membranes in Diabetic Retinopathy
Undiluted vitreous fluid samples were obtained from 36 patients with PDR during pars plana vitrectomy for the treatment of tractional retinal detachment, and/or nonclearing vitreous hemorrhage and processed as described previously (1 (link)–5 (link)). The diabetic patients were 23 males and 13 females whose ages ranged from 27 to 74 years with a median [IQR] of 54 [44-59]. The PDR group consisted of 20 patients who had insulin-dependent diabetes mellitus and 16 patients who had non-insulin-dependent diabetes mellitus. Vitreous fluid samples obtained from 20 patients who had undergone vitrectomy for the treatment of rhegmatogenous retinal detachment with no proliferative vitreoretinopathy (PVR) were used as the control samples. Clinical check-up confirmed that control subjects were free from diabetes or other systemic disease. The controls were 14 males and 6 females whose ages ranged from 26 to 73 years with a median [IQR] of 55 [38-66]. The ages (p = 0.526; Mann-Whitney test) and male/female ratios (p = 0.547; Chi-Square test) did not differ significantly between nondiabetic control patients and PDR patients.
Fourteen patients with PDR undergoing pars plana vitrectomy for the repair of tractional retinal detachment donated epiretinal fibrovascular membranes. At the time of the procedure, using previously published criteria, retinal neovascular activity was clinically graded (36 (link)). We made a distinction between active neovascularization (visible perfused new vessels on the retina or optic disc present within epiretinal membranes) and inactive involuted disease (nonvascularized, white fibrotic epiretinal membranes). For comparison, epiretinal fibrocellular membranes were obtained from ten patients without diabetes undergoing vitreoretinal surgery for the treatment of retinal detachment complicated by PVR. The epiretinal membranes were processed as previously described (1 (link)–4 (link)).
The study was conducted according to the tenets of the Declaration of Helsinki. Before undergoing vitrectomy, all patients signed a preoperative informed written consent and approved the use of the excised epiretinal membranes and aspirated vitreous fluid for further analysis and clinical research. The Research Center and Institutional Review Board of the College of Medicine, King Saud University approved the study design and protocol.
Abu El-Asrar A.M., Ahmad A., Siddiquei M.M., De Zutter A., Allegaert E., Gikandi P.W., De Hertogh G., Van Damme J., Opdenakker G, & Struyf S. (2019). The Proinflammatory and Proangiogenic Macrophage Migration Inhibitory Factor Is a Potential Regulator in Proliferative Diabetic Retinopathy. Frontiers in Immunology, 10, 2752.
Publication 2019
Diabetes Mellitus Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus, Non-Insulin-Dependent Epiretinal Membrane Ethics Committees, Research Females Fibrosis Males Optic Disk Pathologic Neovascularization Patients Pharmaceutical Preparations Planum Poly(ADP-ribose) Polymerases Retina Retinal Detachment Retinal Vessels Traction Vitrectomy Vitreoretinal Surgery Vitreous Hemorrhage Woman
5
Diabetic Retinopathy Outcomes and Safety
The primary outcome was mean change in visual acuity letter score from baseline to 2 years. Secondary efficacy outcomes included visual acuity area under the curve, change in visual field total point score, central subfield thickness change, DME development, and proportion of eyes without PDR on fundus photographs. Pre-specified adverse events related to diabetic retinopathy included vitreous hemorrhage, retinal detachment, vitrectomy, neovascular glaucoma, and iris neovascularization. Pre-specified additional safety outcomes assessed included endophthalmitis, ocular inflammation, cataract surgery, serious adverse events, hospitalizations, death, Antiplatelet Trialists’ Collaboration events, and events in each MedDRA system organ class.
Gross J.G., Glassman A.R., Jampol L.M., Inusah S., Aiello L.P., Antoszyk A.N., Baker C.W., Berger B.B., Bressler N.M., Browning D., Elman M.J., Ferris FL I.I.I., Friedman S.M., Marcus D.M., Melia M., Stockdale C.R., Sun J.K, & Beck R.W. (2015). Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A Randomized Clinical Trial. JAMA, 314(20), 2137-2146.
Publication 2015
Cataract Extraction Diabetic Retinopathy Endophthalmitis Eye Glaucoma, Neovascular Hospitalization Inflammation Iris Pathologic Neovascularization Retinal Detachment Safety Vision Visual Acuity Vitrectomy Vitreous Hemorrhage

Most recents protocols related to «Vitreous Hemorrhage»

1
Vitreous Sample Collection and RNA Extraction
A blood sample (approximately 6 mL) was drawn from the forearm vein into a tube containing an anticoagulant following overnight fasting on the day of surgery. The mixture was immediately centrifuged at 4000×g for 10 min at 4 °C. A vitreous sample (approximately 1 mL) was carefully collected into a 2 mL sterile syringe using a 25-gauge vitreous cutter and manual suction before opening the intraocular irrigation system. If vitreous hemorrhage was present, the surgeon avoided collecting blood components as much blood as possible. All samples were stored in cryopreservation tubes and immediately cooled at − 80 °C until analysis.
After sample collection, total RNA was extracted using TRIzol LS reagent (Invitrogen, Carlsbad, CA, USA) combined with miRNeasy Micro Kit (Qiagen, Hilden, Germany). RNA quality and integrity were measured using Nanodrop (Thermo Fisher Scientific, Waltham, MA, USA) and Agilent 4200 TapeStation.
Zeng L., Zhou M., Wang X., Long X., Ye M., Yuan Y, & Tan W. (2023). Aberrant lncRNA expression in patients with proliferative diabetic retinopathy: preliminary results from a single-center observational study. BMC Ophthalmology, 23, 94.
Publication 2023
Anticoagulants BLOOD Blood Component Transfusion Cryopreservation Forearm Specimen Collection Sterility, Reproductive Suction Drainage Surgeons Surgery, Day Syringes trizol Veins Vitreous Hemorrhage
2
Vortex Vein Characteristics in PCV and AMD
Patients orally agreed to the use of their data in the present study. Ethical approval for this retrospective study was obtained from the Institutional Review Board of the Zhongshan Ophthalmic Centre (approval no. 2022KYPJ173). In total, 180 participants(mean age, 64.12±8.87 years; range, 52-75 years) were recruited in this study, including 109 males and 71 females. All participants underwent ICGA (SPECTRALIS Diagnostic Imaging Platform; Heidelberg Engineering, Inc.) and optical coherence tomography (OCT) (SPECTRALIS® OCT; Heidelberg Engineering Inc.) between January 2018 and January 2022 at the Zhongshan Ophthalmic Centre, Guangzhou, China.
The present study included 63 patients with PCV, 50 with AMD and 67 healthy control group. Based on the results of fundus examination, OCT, fundus fluorescein angiography (FFA) and ICGA, age- and sex-matched patients were grouped based on diagnosis into PCV, AMD and healthy control group. Only one eye was included for patients diagnosed with bilateral PCV or AMD. In healthy participants, only the eye with the best-corrected visual acuity (>20/16) was included.
The following exclusion criteria were adopted: History of prior ocular surgery or trauma(excluded 15 PCV patients); severe vitreous haemorrhage that may affect imaging examination (excluded two PCV patients); any systemic disease that may affect blood flow, such as diabetes mellitus or hypertension (excluded one PCV patients and three AMD patients); central serous chorioretinopathy (CSC); primary glaucoma; optic neuritis; retinal vein occlusion; choroidal melanoma; retinal vasculitis; uveitis; an epiretinal membrane that may affect ocular circulation (excluded one PCV patients and five AMD patients) or moderate to high myopia (defined as a spherical equivalent refractive error in phakic eyes <-3.00 D) (excluded nine healthy participants).
We conducted another screening to exclude the cases who only received monocular ICGA and OCT examination and included 44 cases of unilateral PCV and 18 cases of unilateral AMD. The diseased eye was included in the PCV/AMD group, and the healthy fellow eye was included in the PCV/AMD fellow eye group.
Following intravenous injection of 5 ml 25 mg ICG (Dandong Yichuang Pharmaceutical Co., Ltd), ICGA images were recorded. Early-stage images (5 min after dye injection) were selected for analysis. The vortex veins were separated into four categories according to a previous method (8 (link)). The branches of type I vortex veins do not converge and pass directly through the sclera, whereas all branches of type IV (complete with ampulla) converge to form the ampulla, which is a complete vortex system. Type IV systems have a larger root area due to the dilated ampulla (8 (link)). The fundus was divided into four quadrants: Superior and inferior temporal and superior and inferior nasal. Patient characteristics, such as sex, age, number, location and type of vortex veins were recorded. The sketching tool of the retinal device was used to mark the root area and diameter of the thickest branch of each vortex vein (Fig. 1). The centre of a concentric circle was placed on the macula, the thickest vortex vein branch intersecting with the outermost circle was selected and its diameter was measured and stored as the central vortex vein diameter (CVVD). The ends of each vortex vein branch were connected with a smooth curve and the area enclosed by the curve was defined as the root area of the vortex vein (RAVV). The width of the thickest first-order branch of the vortex vein was defined as the diameter of the peripheral thickest branch (DPTB). The mean RAVV (MRAVV) and MDPTB were calculated. Vortex vein anastomosis was observed when vortex vein branches connected the two vortex vein systems on IGCA. The percentage of eyes with vortex vein anastomosis in each group was calculated and recorded as the percentage of vortex vein anastomosis (PVVA). Subfoveal choroidal thickness (SFCT) was measured using SPECTRALIS® OCT device. All labelling was performed separately by two experienced ophthalmologists (CXC and XMX) and the mean of the two measurements was used as the final data.
Cai C.X., Xiong X.M., Li T., Liu B.Q., Huang X.H., Yu S.S., Lin Z.Q., Wang Q., Cui J.L., Lu L, & Lin Y. (2023). Vortex vein engorgement and different shapes of venous drainage systems in polypoid choroidal vasculopathy vs. age‑related macular degeneration on indocyanine green angiography. Experimental and Therapeutic Medicine, 25(4), 162.
Publication 2023
Central Serous Chorioretinopathy Choroid Diabetes Mellitus Epiretinal Membrane Ethics Committees, Research Eye Females Fluorescein Angiography Glaucoma Healthy Volunteers High Blood Pressures Macula Lutea Males Medical Devices Melanoma Myopia Nose Ophthalmologists Optic Neuritis Patients Pharmaceutical Preparations Plant Roots Refractive Errors Retina Retinal Vasculitis Retinal Vein Occlusion Sclera Surgical Anastomoses Thalamostriate Veins Tomography, Optical Coherence Uveitis Veins Vision Visual Acuity Vitreous Hemorrhage Wounds and Injuries
3
Aqueous Flare Changes After Panretinal Photocoagulation in Diabetic Retinopathy
The records of 352 patients who underwent PRP due to PDR in one eye Department of Retina Beyoglu Eye Training and Research Hospital between January and March 2021 were reviewed retrospectively. Patients who underwent PRP in one eye but not in the other eye were included in the study. Patients who had previous ocular surgery, patients using steroids or other anti-inflammatory drugs, patients who received anti-VEGF therapy in the past month, patients with a history of ocular trauma/uveitis, and patients with vitreous hemorrhage, macular edema, tractional retinal detachment, and patients with HbA1c higher than 8.0 were excluded from the study. PRP applied eyes were taken as the study group and the other PRP-naive eyes were taken as the control group.
The study was carried out in accordance with the Declaration of Helsinki and was approved by the University of Health Sciences Hamidiye Scientific Research Ethics Committee with the decision number 13/2 on May 13, 2022. Informed consent was obtained from all patients in the study.
All patients underwent a full ophthalmologic examination before retinal photocoagulation. The best corrected visual acuity, IOP measured by Goldmann applanation tonometry, biomicroscopy, and dilated fundus examination findings were recorded. The other systemic/ocular diseases, surgeries, and drug use were questioned.
Retinal photocoagulation was performed with the pattern scan laser (PASCAL) system (PASCAL Synthesis, Topcon Medical Laser Systems, Santa Clara, CA) with a 200 micron spot size and an exposure time of 20–30 ms. The laser power was started with 200 mW and increased until a gray-white lesion was formed on the retina. 1000–1200 numbers of pulse were made in a single session. Any medication was not administered after PRP.
The laser flare meter (FC-700, Kowa Co. Ltd, Tokyo, Japan) was used to measure flare of aqueous humor. Measurements were performed by the same clinician. The mean of five consecutive reliable measurements was taken as the aqueous flare value. The values of flare meter were expressed as photon counts per millisecond (pc/ms).
Laser flare photometry and Goldmann applanation tonometry were both performed just before PRP and at the 1st and 24th h after PRP. At each visit, measurements were performed in both eyes consecutively and the other eye was accepted as the control eye.
“Statistical Package for the Social Sciences” version 20 software was used for statistical analysis. Continuous variables were reported as mean, standard deviation, and range. Categorical variables were expressed as absolute numbers and percentages. After evaluating the normality of the data with the Shapiro–Wilk test; the repeated measures analysis of variance (ANOVA) test with Greenhouse-Geisser correction was used to compare the values before and after retinal photocoagulation. If there was a significant difference with the repeated measures ANOVA test, Bonferroni correction was used to adjust of pairwise comparisons. Comparisons with the control eyes were made using an independent sample t-test. The correlation between variables was evaluated with the Pearson correlation coefficient. If p<0.05, the difference between values was considered statistically significant.
Atik B.K., Altan C., Pehlivanoglu S, & Ahmet S. (2023). Aqueous Flare and Intraocular Pressure in the Early Period Following Panretinal Photocoagulation in Patient with Proliferative Diabetic Retinopathy. Beyoglu Eye Journal, 8(1), 26-31.
Publication 2023
Anabolism Anti-Inflammatory Agents Aqueous Flare Edema, Macular Ethics Committees, Research Eye Eye Injuries Light Coagulation Operative Surgical Procedures Patients Pharmaceutical Preparations Photometry Pulse Rate Radionuclide Imaging Retina Retinal Detachment Slit Lamp Steroids Therapeutics Tonometry, Ocular Traction Uveitis Vascular Endothelial Growth Factors Vision Visual Acuity Vitreous Hemorrhage
4
Diabetic Retinopathy Categorization in Chinese Patients
This retrospective case–control study included patients with T2DM who visited the Department of Ophthalmology and the Department of Endocrinology of the Fourth Hospital of Hebei Medical University between July 2014 and July 2016. T2DM was diagnosed according to the International World Health Organization (WHO) T2DM diagnostic criteria (1999) [26 ]. The healthy controls were unrelated individuals who received routine physical examinations between July 2014 and July 2016. All subjects were of Han ethnicity and from families living in Shijiazhuang, Hebei Province, China, for at least three generations.
The subjects were divided into four groups (one control group and three patient groups) according to the 2002 International Clinical Classification Criteria for DR [27 (link)]. The DM group included the T2DM patients without fundus examination abnormalities. The PDR group included the patients with one or more of the following: neovascularization, vitreous hemorrhage, and preretinal hemorrhage. The NPDR group included the patients with microangioma, intraretinal hemorrhage, and microvascular abnormalities, but without the PDR-specific findings.
Yuan Y., Shao C., Guan Y., Lu H., Wang D, & Zhang S. (2023). Association between the VEGFR-2 -604T/C polymorphism (rs2071559) and type 2 diabetic retinopathy. Open Life Sciences, 18(1), 20220081.
Publication 2023
Congenital Abnormality Diagnosis DR 27 Ethnicity Hemorrhage Pathologic Neovascularization Patients Physical Examination System, Endocrine Vitreous Hemorrhage
5
Aqueous Humor Proteomics in CRVO
The study was conducted in compliance with the Institutional Review Board of Kyoto Prefectural University of Medicine which approved the study (permission RBMR-C-864-6). The study adhered to the tenets of the Helsinki Declaration. Aqueous humor samples from treatment-naïve patients with CRVO complicated by macular edema with onset within 3 months (n = 28) and age-matched controls (n = 20) were donated from the biobank of Kyoto Prefectural University of Medicine, Kyoto, Japan (Table 1). Informed consent to use samples from the biobank was obtained from all patients after explaining the nature and possible consequences of the study. There were no statistically significant differences in age between the two groups as verified by Student's t-test (see Table 1). In the CRVO group, the inclusion criteria were ≥20 years of age, symptom onset of visual disturbance within 3 months, and macular edema >300 µm by OCT. Exclusion criteria in the CRVO group were iris rubeosis, hyphema, neovascular glaucoma, vitreous hemorrhage, retinal neovascularization, previous retinal photocoagulation, other retinal disease, or use of topical treatments within the last 3 months. Control samples were from age-matched patients from whom aqueous humor samples were obtained prior to cataract surgery. Patients in the control group had no ocular disease except for cataract. The data, including best corrected visual acuity (BCVA) were collected from the electronic charts of patients at Kyoto Prefectural University of Medicine. BCVA was measured using the Japanese standard Landolt visual acuity chart, and then converted to the logarithm of the minimum angle of resolution (logMAR). Swept source OCT was used (DRI-OCT Triton; Topcon, Tokyo, Japan). The severity of macular edema was measured as central retinal thickness (CRT), which was defined as the distance between the outer border of the hyper-reflective retinal pigment epithelium and the inner border of the internal limiting membrane at the center of the fovea measured using the caliper tool of the Topcon OCT software. The grader (author K.K.) was masked to the proteomics data and ELISA data. CRT was measured two times and the mean value was calculated. The intraclass correlation coefficient of the grader was 0.95. Fluorescein angiography (FA) was performed using a confocal scanning laser ophthalmoscope (Heidelberg Retina Angiograph 2; Heidelberg Engineering, Heidelberg, Germany) and the area of retinal non-perfusion was measured in optic disc areas using the “draw lesion” tool in Heidelberg Retinal Angiography 2.
Additional aqueous humor samples from patients with CRVO (n = 15) and control samples (n = 5) were obtained from the biobank for validation by enzyme-linked immunosorbent assay (ELISA; Table 2). CRVO samples and control samples were age-matched and selected according to the inclusion and exclusion criteria specified above. For samples obtained for ELISA, the Mann-Whitney U test was used to verify that there was no significant difference in age between the groups (see Table 2).
Cehofski L.J., Kojima K., Kusada N., Rasmussen M., Muttuvelu D.V., Grauslund J., Vorum H, & Honoré B. (2023). Macular Edema in Central Retinal Vein Occlusion Correlates With Aqueous Fibrinogen Alpha Chain. Investigative Ophthalmology & Visual Science, 64(2), 23.
Publication 2023
Administration, Topical Angiography Aqueous Humor Cataract Cataract Extraction Edema, Macular Enzyme-Linked Immunosorbent Assay Erythema Ethics Committees, Research Eye Fluorescein Angiography Glaucoma, Neovascular Hyphema Iris Japanese Light Coagulation Ophthalmoscopes Optic Disk Patients Perfusion Pharmaceutical Preparations Reflex Retina Retinal Diseases Retinal Neovascularization Retinal Pigment Epithelium Specimen Handling Tissue, Membrane Visual Acuity Vitreous Hemorrhage

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More about "Vitreous Hemorrhage"

Vitreous Hemorrhage is a condition where bleeding occurs within the vitreous humour, the clear, jelly-like substance that fills the eye's interior.
This can obstruct vision and is often a symptom of underlying eye or health conditions.
Causes of vitreous hemorrhage include retinal tears, diabetic retinopathy, age-related macular degeneration, eye injuries, and blood vessel abnormalities.
Diagnosing and treating vitreous hemorrhage often involves various imaging techniques and procedures.
Optos California and CR2-45 NM Nonmydriatic Fundus Cameras can be used to visualize the retina and detect any underlying issues.
Fluorescein angiography using Micron IV or CTB-FITC may also be performed to identify the source of bleeding.
Treatment options may include medication, such as Bevacizumab or Phenylephrine and Tropicamide eye drops, or surgical procedures like vitrectomy.
Researchers studying vitreous hemorrhage can utilize tools like PubCompare.ai to optimize their research protocols and find the best products from literature, preprints, and patents.
This helps ensure the accuracy and reproducibility of their findings, which is crucial for understanding the underlying causes and developing effective treatments for this condition.