Datasets from articles in any language were eligible for inclusion if they included diagnostic classification for current major depressive disorder or major depressive episode on the basis of a validated semistructured or fully structured interview conducted within two weeks of PHQ-9 administration among participants aged 18 years or over who were not recruited from youth or psychiatric settings or because they were identified as having symptoms of depression. We required the diagnostic interviews and PHQ-9 to be administered within two weeks of each other because the Diagnostic and Statistical Manual of Mental Disorders (DSM) and international classification of diseases (ICD) diagnostic criteria for major depression specify that symptoms must have been present in the previous two weeks. We excluded patients from psychiatric settings and those already identified as having symptoms of depression because screening is done to identify previously unrecognized cases.
Datasets in which not all participants were eligible were included if primary data allowed selection of eligible participants. For defining major depression, we considered major depressive disorder or major depressive episode based on the DSM or ICD criteria. If more than one was reported, we prioritized major depressive episode over major depressive disorder, as screening would attempt to detect depressive episodes and further interview would determine whether the episode was related to major depressive disorder or bipolar disorder, and DSM over ICD. Across all studies, there were 23 discordant diagnoses depending on classification prioritization (0.1% of participants).
Two investigators independently reviewed titles and abstracts for eligibility. If either deemed a study potentially eligible, two investigators did full text review independently, with disagreements resolved by consensus, consulting a third investigator when necessary. We consulted translators for languages other than those in which team members were fluent.
Datasets in which not all participants were eligible were included if primary data allowed selection of eligible participants. For defining major depression, we considered major depressive disorder or major depressive episode based on the DSM or ICD criteria. If more than one was reported, we prioritized major depressive episode over major depressive disorder, as screening would attempt to detect depressive episodes and further interview would determine whether the episode was related to major depressive disorder or bipolar disorder, and DSM over ICD. Across all studies, there were 23 discordant diagnoses depending on classification prioritization (0.1% of participants).
Two investigators independently reviewed titles and abstracts for eligibility. If either deemed a study potentially eligible, two investigators did full text review independently, with disagreements resolved by consensus, consulting a third investigator when necessary. We consulted translators for languages other than those in which team members were fluent.