> Disorders > Sign or Symptom > Nausea

Nausea

Nausea is an unpleasant, subjective sensation of an urge to vomit.
It may precede vomiting, but not all nausea leads to vomiting.
Nausea can be caused by various factors, including medication, pregnancy, motion sickness, gastrointestinal disorders, and chemotherapy.
Effective management of nausea often involves identifying and treating the underlying cause.
Various pharmacological and non-pharmacological interventions, such as antiemetic medications, acupressure, and relaxation techniques, may be employed to alleviate nausea and improve quality of life.
Reasearchers can leverge PubCompare.ai's AI-driven protocol comparision tool to enhace reproducibilty and accuarcy in their nausea research, helping identify the best treatments and products.

Most cited protocols related to «Nausea»

Evaluating Stress-Related Symptom Prevalence

We have used a list of various possibly stress, anxiety or somatoform-related symptoms such as irritability, fatigue, hostility, feeling of tension, inability to concentrate, musculoskeletal symptoms (neck or upper back pain or discomfort), gastrointestinal symptoms (abdominal pain or discomfort, nausea, alterations in bowel habits), headaches, sleep disturbances, tachycardia, increased blood pressure, palpitations, chest discomfort, dizziness and substance abuse [27 ]. This checklist is not intended as a psychometric tool. It consists of nonspecific symptoms described as related to stress. Stress symptoms, in general, claim more sensitivity than specificity, as such, we were particularly interested on the number of cardinal stress manifestations and not on the evaluation of a situation or psychological state. Participants were asked about the frequency of experiencing these symptoms during the last year and each symptom was binary categorized as frequent or not. Some of these symptoms may not well be expressed as binary variables and suffered low specificity but our interest was to evaluate the coexistence of these stress-related symptoms with high PSS scores. The total number of frequent symptoms was calculated and each participant was categorized in five groups (symptoms less or equal to three, four, five, six and more than six).

Andreou E., Alexopoulos E.C., Lionis C., Varvogli L., Gnardellis C., Chrousos G.P, & Darviri C. (2011). Perceived Stress Scale: Reliability and Validity Study in Greece. International Journal of Environmental Research and Public Health, 8(8), 3287-3298.

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Publication 2011

Abdominal Pain Anxiety Back Pain Blood Pressure Chest Defecation Fatigue Headache Hostility Nausea Neck Psychometrics Sleep Disorders Substance Abuse

Metabolic Profiling of Calf Muscle Using 7T MRI

The protocol was approved by the Institutional Review Board. Informed consent was obtained from all participants prior to the study. Twenty healthy adults (twelve females and eight males) age 22–52 years (average 34 years; without diabetes or known vascular disease) were studied supine or prone in a 7T system (Achieva, Philips Medical Systems, Cleveland, OH). Spectra were acquired with a partial-volume quadrature transmit/receive coil customized to fit the shape of a human calf. Axial, coronal, and sagittal T₂-weighted turbo spin echo images were initially acquired of the left calf muscle. Typical parameters were: field of view 180 × 180 mm, repetition time (TR) 1,500 ms, echo time (TE) 75 ms, turbo factor 16, and number of acquisitions (NA), 1. Single-voxel stimulated echo acquisition mode (STEAM) (typical parameters: voxel size 5 × 5 × 5 mm³ (∼0.1 ml), TR 2,000 ms, TE 20 ms, spectral BW of 4 kHz, number of points (NP) 4,096 and zero-filled to 8,192 prior to Fourier transform, NA 16, no water suppression) was used to acquire ¹H spectra from tibial bone marrow and subcutaneous fat tissue. To correct individual resonances for relaxation effects, T₁ and T₂ were measured in seven of the subjects. T₁ was measured using inversion-recovery, with nine inversion delay times in the range of 5 ms to 3,000 ms, with TR 7 s and TE 40 ms. T₂ was measured by using ten TE values from 20 ms to 180 ms, with TR 8 s. Subjects were instructed to move slowly in the scan room. The entire scanning session was 60 min or less and it was well-tolerated by all subjects. All subjects were interviewed after the exam and again at 24 h after the exam. All subjects specifically denied dizziness, nausea, vertigo, headaches, or visual changes.

Ren J., Dimitrov I., Sherry A.D, & Malloy C.R. (2008). Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla. Journal of Lipid Research, 49(9), 2055-2062.

Publication 2008

Adult Bone Marrow Diabetes Mellitus ECHO protocol Ethics Committees, Research Females Headache Homo sapiens Inversion, Chromosome Males Muscle Tissue Nausea Subcutaneous Fat Tibia Vascular Diseases Vertigo Vibration

Assessing Symptom Changes in Multinational Cancer Patients

Data collection occurred between December 8, 2011 and April 30, 2014. We collected baseline patient characteristics, including age, sex, race, education level, cancer diagnosis, CAGE questionnaire [15 (link)] and MDAS [16 (link)] during the first study visit. For the purpose of this study, we considered all Brazilians and Chileans to be of Hispanic ethnicity. We also assessed ESAS and Karnofsky performance status during both the first and second visits, and Patient's Global Impression Scale (PGI) at the second visit. The site principal investigators all visited Houston to learn about the study procedures. To ensure data is collected in an accurate fashion, the study PI had regular teleconference with the research team at each site 1-2 times per month to provide training and longitudinal monitoring.
ESAS assesses the average intensity of 10 symptoms (pain, fatigue, nausea, depression, anxiety, drowsiness, shortness of breath, appetite, feelings of well-being and sleep) over the past 24 hours, each with an 11-point numerical rating scale that ranges from 0 (no symptom) to 10 (worst intensity) [3 (link)]. It has been translated into the languages in respective countries and by MAPI Research trust (i.e. English, Arabic, Portugese, Spanish, Korean and Hindi) and validated both linguistically and psychometrically [5 (link), 8 (link), 11 (link), 17 (link), 18 (link)].
PGI is a validated global rating of change scale used to evaluate subjective patients’ response at the second visit [19 (link), 20 (link)]. Patients were asked to answer the question for each of the 10 ESAS symptoms: “How is your symptom over the last 24 hours compared to your last visit?” for each of the 10 ESAS symptoms (“better”, “about the same”, “worse”). If the patient answered “better”, they were asked “how much better?” (“much better”, “better”, “a little better”). Alternatively, if the patient answered “worse”, they were asked “how much worse?” (“much worse”, “worse”, “a little worse”). PGI has been commonly used as a secondary outcome in a large number of pain studies and also used in several studies as an anchor for establishing clinical importance levels [21 (link), 22 (link)].

Hui D., Shamieh O., Paiva C.E., Perez-Cruz P.E., Kwon J.H., Muckaden M.A., Park M., Yennu S., Kang J.H, & Bruera E. (2015). Minimal Clinically Important Differences in the Edmonton Symptom Assessment Scale in Cancer Patients: A Prospective Multicenter Study. Cancer, 121(17), 3027-3035.

Publication 2015

3,4-Methylenedioxyamphetamine Anxiety Diagnosis Dyspnea Ethnicity Fatigue Feelings Hispanic or Latino Hispanics Koreans Malignant Neoplasms microbial alkaline proteinase inhibitor Nausea Pain Patients Sleep Somnolence

Development and Validation of the VAS-IBS

Items to be used in a questionnaire can be generated from the literature [14 ,15 ], and to get a conceptualization of the construct of interest a literature review of symptoms and inconveniences experienced by patients with IBS was performed. The most outstanding physical symptoms identified were divided into six main groups; Abdominal Pain, Diarrhoea, Constipation, Bloating and Flatulence, Abnormal bowel passage and Vomiting and Nausea. All symptoms except Vomiting and Nausea also support the diagnosis of IBS. Symptoms included in the group Abnormal bowel passage (straining, urgency or feeling of incomplete evacuation) might also be connected to diarrhoea, to constipation as well as to the use of laxatives [16 (link)] and these inconveniences have been reported by patients as minor problems [7 (link)]. Since it might be difficult to evaluate symptoms associated with Abnormal bowel passage on a scale, and the VAS-IBS should serve as a complement to the anamnesis, it may be preferable to discuss these symptoms. One item for each physical symptom was created; Abdominal Pain, Diarrhoea, Constipation, Bloating and Flatulence, and Vomiting and Nausea. An overall item concerning the patient's bowel symptoms was also included in the questionnaire, and the intension was to use it as a control item for psychometric testing. This item was supposed to be removed in the final version of the VAS-IBS.
Besides physical health problems, IBS also has a negative influence on a person's mental health [17 (link),18 (link)] as well as on his/hers daily life [19 (link),20 (link)], and therefore questions related to these subjects were added. However, the focus of the questionnaire should still be on the patient's physical symptoms. Totally three items were created. One item related to mental health and two items related to daily life to see which of them best corresponded to the intention of the questionnaire. It is a common approach to have a number of items addressing a single underlying characteristic, and to use only one, all-inclusive, self-administered, single, global and item-specific question of each concept may appear to be insufficient. However, a single question may well provide information on all aspects of a phenomenon, and a summary of an individual's perception [21 (link)].
The time window was set to during the previous week, since that is the same time window as for the Gastrointestinal Symptom Rating Scale (GSRS) and the Psychological General Well-Being Index (PGWB), which were chosen as comparable questionnaires to test the criterion validity of the VAS-IBS.

Bengtsson M., Ohlsson B, & Ulander K. (2007). Development and psychometric testing of the Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS). BMC Gastroenterology, 7, 16.

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Publication 2007

Abdominal Pain Concept Formation Constipation Diagnosis Diarrhea Flatulence Immunologic Memory Inclusion Bodies Intestines Laxatives Mental Health Nausea Patients Physical Examination

Vestibular and Ocular Motor Screening Protocol

The VOMS was developed to assess vestibular and ocular motor impairments via patient-reported symptom provocation after each assessment. The VOMS employed in this study consisted of brief assessments in the following 5 domains: (1) smooth pursuit, (2) horizontal and vertical saccades, (3) convergence, (4) horizontal vestibular ocular reflex (VOR), and (5) visual motion sensitivity (VMS). A copy of the VOMS form and standardized instructions for each test are provided in Appendix 1 (available in the online version of this article at http://ajsm.sagepub.com/supplemental). A visual depiction representing each test is provided in Appendix 2 (available online). Patients verbally rate changes in headache, dizziness, nausea, and fogginess symptoms compared with their immediate preassessment state on a scale of 0 (none) to 10 (severe) after each VOMS assessment to determine if each assessment provokes symptoms. Convergence was assessed by both symptom report and objective measurement of the near point of convergence (NPC; see description in Appendix 1). The NPC values were averaged across 3 trials, and normal NPC values are within 5 cm.^{32 (link)} It is important to note that only horizontal VOR data are reported in this article; however, the VOMS has since been modified to incorporate the assessment of VOR in both the horizontal and vertical planes. The VOMS takes approximately 5 to 10 minutes to administer.

Mucha A., Collins M.W., Elbin R.J., Furman J.M., Troutman-Enseki C., DeWolf R.M., Marchetti G, & Kontos A.P. (2014). A Brief Vestibular/Ocular Motor Screening (VOMS) Assessment to Evaluate Concussions: Preliminary Findings. The American journal of sports medicine, 42(10), 2479-2486.

Publication 2014

Fog Headache Hypersensitivity Nausea Ophthalmoplegia Patients Pursuit, Smooth Reflex, Righting Vestibular Labyrinth Vision

Most recents protocols related to «Nausea»

Dietary Fructose Intolerance Treatment

Not available on PMC !

Example 14

An adult patient with dietary fructose intolerance presents with one or more of symptoms such as abdominal bloating, flatulence, pain, distension, diarrhea and nausea. Treatment with the preparation of the invention is initiated by the clinician at an effective dose, which mitigates fructose-induced symptoms. Assessment of symptoms and testing are periodically performed. The dose of the treatment is adjusted as required by the clinician in attendance to manage symptoms of the dietary fructose-related condition. The subject may be treated with other drugs concurrently and may or may not be under restricted diet. Treatment with the preparation of the present invention is able to mitigate one or more symptoms related to dietary fructose.

US11865151B2. Live biotherapeutics for the treatment of carbohydrate disorders (2024-01-09). GUTSYBIO INC. [US]. Inventors: Genevieve Hansen [US].

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Patent 2024

Abdomen Adult Diarrhea Diet Dietary Restriction Flatulence Fructose Intolerances, Fructose Nausea Pain Patients Pharmaceutical Preparations Symptom Assessment

Fructose Intolerance Detoxification

Not available on PMC !

Example 13

A group of adult subjects who presents one or more symptoms such as abdominal bloating, flatulence, pain, distension, diarrhea and nausea within 2 to 8 hours after drinking a beverage containing 25 g fructose is administered an oral dose of the preparation of the invention prior to the fructose provocation. During the following 8 hours, multiple tests are performed including breath test and blood fructose concentration evaluation. It is observed that the administration of the preparation of the invention decreases the production of hydrogen gas in the respiratory air and it levels off blood fructose level rapidly. These data confirm that preparation of the invention can efficiently detoxify fructose.

US11865151B2. Live biotherapeutics for the treatment of carbohydrate disorders (2024-01-09). GUTSYBIO INC. [US]. Inventors: Genevieve Hansen [US].

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Patent 2024

Abdomen Adult Beverages BLOOD Breath Tests Diarrhea Diet Flatulence Fructose Hydrogen Nausea Pain Respiratory Rate

Colorectal Cancer Surgery Outcomes

Patient demographics and perioperative outcomes were obtained from the prospectively collected colorectal cancer database. Patient demographic data included age, sex, preoperative CEA level, body mass index (BMI), American Society of Anesthesiologists (ASA) physical status (PS) classification, and tumor location. Operative outcomes included the total operation time, incision length, blood loss, specimen extraction site, and anastomosis method. Conversion was defined as the transition from laparoscopic to open surgery. Clinical outcomes included postoperative pain management, time to gas pass, sips of water, soft diet, hospital stay, pain score, use of painkillers on postoperative days 1 and 2, postoperative morbidity, and mortality within 30 days. POI was diagnosed when 2 or more of the following 5 criteria were met on or after the 4th postoperative day without resolution of POI: nausea or vomiting, inability to tolerate an oral diet over the previous 24 hours, absence of flatus over the previous 24 hours, abdominal distension, and radiologic confirmation [15 (link)]. Morbidity was classified using the Clavien-Dindo (CD) classification. On postoperative days 1 and 2, postoperative wound pain was measured using a numeric pain rating scale, with endpoints labeled “no pain” (scale 0) and “worst possible pain” (scale 10). Pathological outcomes for colonic adenocarcinoma included tumor stage, histology, retrieved lymph nodes, tumor size, and resection margins. Tumors were classified according to the 8th edition of the American Joint Committee on Cancer (AJCC) cancer staging system.

Kim S., Bae S.U., Jeong W.K., Baek S.K, & Son Y.G. (2023). Effect of intracorporeal anastomosis on postoperative ileus after laparoscopic right colectomy. Annals of Surgical Treatment and Research, 104(3), 156-163.

Publication 2023

Abdomen Analgesics Anesthesiologist BAD protein, human Colon Adenocarcinomas Colorectal Carcinoma Diet Flatulence Hemorrhage Index, Body Mass Joints Nausea Neoplasms Neoplasms by Site Nodes, Lymph Pain, Postoperative Patients Physical Examination Staging, Cancer Surgical Anastomoses Surgical Margins Surgical Procedures, Laparoscopic Wounds

EORTC QLQ-C30 for Assessing QoL in Allo-HSCT

The European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (QLQ-C30) was used to assess QoL at baseline (i.e., on day 8 or 7 before allo-HSCT) [19 (link)]. The QLQ-C30 includes five functional scales (role, physical, cognitive, emotional and social), three symptom scales (nausea/vomiting, fatigue, and pain), and six single items (insomnia, dyspnea, appetite loss, constipation, diarrhea, and financial problems). This questionnaire also includes a global health status/quality of life (QoL) scale. All scales and single items are transformed into standardized scores ranging from 0 to 100, with higher scores for the functioning scales and global health status/QoL scale indicating better outcomes, while higher scores on the symptom scales and single items indicate greater symptom severity [19 (link)].

Gudmundstuen A.M., Efficace F., Tjønnfjord G.E., Skaarud K.J., Cottone F., Hjermstad M.J, & Iversen P.O. (2023). The prognostic value of patient-reported outcomes in allogeneic hematopoietic stem cell transplantation: exploratory analysis of a randomized nutrition intervention trial. Annals of Hematology, 102(4), 927-935.

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Publication 2023

ALLO 7 Anorexia Cognition Constipation Diarrhea Dyspnea Emotions Europeans Fatigue Malignant Neoplasms Nausea Pain Physical Examination Sleeplessness

Comprehensive Medical History Encoding

One-hot encoding was used to covert PMH data into categorical variables. Instead of grouping past medical history elements into categories (e.g., history of cancer or history of diabetes), specific diagnosis codes were included, to assess differential risk that may arise from different severity or manifestations of medical conditions. ROS and PE findings were represented by two binary variables, one representing occurrence of a “pertinent positive” (e.g., positive review of systems for headache) the other when occurring as a “pertinent negative” (e.g., negative review of systems for nausea). Absent or missing documentation was therefore represented as a null value for both pertinent positive and pertinent negative variables. Numerical values (e.g., age, pain rating) were coded as continuous variables. Additional details of feature encoding are given in Item 4 in S1 File.

Tu L.H., Malhotra A., Venkatesh A.K., Taylor R.A., Sheth K.N., Yaesoubi R., Forman H.P., Sureshanand S, & Navaratnam D. (2023). Clinical criteria to exclude acute vascular pathology on CT angiogram in patients with dizziness. PLOS ONE, 18(3), e0280752.

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Publication 2023

Diabetes Mellitus Diagnosis Headache Malignant Neoplasms Nausea Pain

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More about "Nausea"

Nausea is an unpleasant, subjective sensation of an urge to vomit.
It may precede emesis, but not all queasiness leads to retching.
Nausea can be caused by various factors, including medication, pregnancy, motion sickness, gastrointestinal conditions, and chemotherapy.
Effective management of nausea often involves identifying and treating the underlying cause.
Various pharmacological and non-pharmacological interventions, such as antiemetic drugs, acupressure, and relaxation techniques, may be used to alleviate nausea and improve quality of life.
Researchers can leverage PubCompare.ai's AI-driven protocol comparison tool to enhance reproducibility and accuracy in their nausea research, helping identify the best treatments and products.
This innovative platform can be used in conjunction with statistical software like SAS version 9.4, Stata 13, SPSS version 23, and MATLAB to optimize study design, data analysis, and reporting.
The PubCompare.ai tool leverages advanced natural language processing and machine learning algorithms to systematically compare nausea-related protocols across the literature, pre-prints, and patents.
This helps researchers stay up-to-date with the latest developments, avoid duplicating efforts, and make more informed decisions about their study approaches.
By using PubCompare.ai, researchers can take the guesswork out of their nausea research and enhance the reproducibility and accuracy of their findings.
This can lead to more robust and impactful contributions to the field, ultimately improving the understanding and management of this common and debilitating condition.