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Nervousness

Nervousness: A common emotional state characterized by feelings of tension, apprehension, and worry.
Often associated with physical symptoms such as increased heart rate, sweating, and trembling.
Effective management of nervousness can improve research outcomes and reproducibility.
PubCompare.ai's AI-driven platform helps researchers identify the most effective protocols and products to optimize their Nervousness research, ensuring accurate and reliable results.

Most cited protocols related to «Nervousness»

1
Aging, Memory, and Neurological Evaluation
The Memory and Aging Project is funded by the National Institute on Aging and was approved by the Institutional Review Board of Rush University Medical Center. Older persons without known dementia must agree to an assessment of risk factors, blood donation, and a detailed clinical evaluation each year. Further, all participants also agree to donation of brain, the entire spinal cord, and selected nerve and muscles at the time of death.
Study participants are primarily recruited from retirement communities throughout northeastern Illinois Fig. (1). The study primarily enrolls residents of continuous care retirement communities. Several features of these facilities and the study design enhance the validity and generalizability of the study. Because the only exclusion is the inability to sign the Anatomical Gift Act, and because all clinical evaluations are performed as home visits, co-morbidities common in population-based epidemiologic studies are well represented; this reduces the “healthy volunteer effect” seen in many cohort studies [30 (link)]. The home visits reduce participant burden facilitating high rates of follow-up. Follow-up rates are further enhanced because these facilities provide all levels of care from independent living to unskilled and skilled nursing on campus. This also enhances autopsy rates as many participants die on campus and the Anatomical Gift Act allows us to work directly with facility staff and the funeral home to arrange the autopsy. Residents of continuous care retirement communities are predominantly white and tend to be more affluent. Therefore, the study also recruits from Section 8 and Section 202 housing subsidized by the Department of Housing and Urban Development, retirement homes, and through local churches and other social service agencies serving minorities and low-income elderly.
The study design allows the following types of analyses to be conducted within a single dataset Fig. (2): 1) the relation of risk factors with incident AD, incident MCI, and decline in cognitive and motor function; 2) the relation of neurobiologic indices with AD, MCI, and cognitive and motor function; and 3) modeling neurobiologic pathways linking risk factors to clinical phenotypes.
Bennett D.A., Schneider J.A., Buchman A.S., Barnes L.L., Boyle P.A, & Wilson R.S. (2012). Overview and Findings from the Rush Memory and Aging Project. Current Alzheimer research, 9(6), 646-663.
Publication 2012
Aged Autopsy Blood Donation Brain Cognition Continuity of Patient Care Dementia Disorders, Cognitive Ethics Committees, Research Healthy Volunteers Memory Minority Groups Nervousness Phenotype Spinal Cord Temporal Muscle Urban Development Vision Visit, Home
2
Kessler Psychological Distress Scale (K6)
The K6 consists of six questions that ask subjects to rate how often they felt (i) nervous, (ii) hopeless, (iii) restless or fidgety, (iv) so depressed that nothing could cheer you up, (v) that everything was an effort, and (vi) worthless over one of two recall periods: the past-month (respondents are were asked to rate how often the symptoms occurred in the 30 days before the survey) and the worst-month (respondents are asked about the 30-day period during the past 12 months when they had the most severe psychological distress). Some WMH surveys used only one of these recall periods while others used both. The decision about which recall period to used hinged on whether the investigators were interested in calibrating SMI point prevalence (most useful for screening in clinical settings), 12-month prevalence (most useful for estimating prevalence in surveys used for health policy planning purposes, as the year is the usual health policy planning period), or both.
The surveys that used both recall periods began by administering the past-month questions and then asked respondents a single question about whether there was any other 30-day period in the past 12 months when they had these symptoms more frequently than in the past 30 days. If not, the past-month responses were also used as the worst-month responses. If the respondent reported that there was a worst month, though, he or she was asked to think about that time in answering the six questions a second time. The six K6 questions had to be repeated for about 20% respondents when this two-part approach was used. That is, about 80% of the time respondents reported that there was no other 30-day period in the past 12 months that was worse than the last 30 days. The response options, which were identical in the two recall periods, were all of the time, most of the time, some of the time, a little of the time, and none of the time. These were coded 4-0, which means that the unweighted summary scale has a 0-24 range. However, it is also possible to weight either the scale items (as in a factor analysis factor-weighted scale) (Kim, 1993 ) or to weight the item responses within each item (as in an analysis of nested dichotomous items in an item response theory [IRT] modeling approach) (Embretson and Reise, 2000 ).
Kessler R.C., Green J.G., Gruber M.J., Sampson N.A., Bromet E., Cuitan M., Furukawa T.A., Gureje O., Hinkov H., Hu C., Lara C., Lee S., Mneimneh Z., Myer L., Oakley‐Browne M., Posada‐Villa J., Sagar R., Viana M.C, & Zaslavsky A.M. (2010). Screening for serious mental illness in the general population with the K6 screening scale: results from the WHO World Mental Health (WMH) survey initiative. International Journal of Methods in Psychiatric Research, 19(Suppl 1), 4-22.
Publication 2010
factor A Feelings Mental Recall Nervousness Psychological Distress
3
Religious Orders Study: Neurobiology of Aging
The Religious Orders Study enrolls Catholic nuns, priests and brothers, from more than 40 groups across the United States (Figure 1). Participants are without known dementia and agree to annual clinical evaluation and brain donation (some in the Chicago area also agree to donate, spinal cord, nerve, and muscle). Each subject signs a consent form and an Anatomical Gift Act. The study was approved by the Institutional Review Board of Rush University Medical Center.
The study primarily recruits persons living communally, including employed (e.g., Teaching Orders) and retired (e.g., Missionary Orders) persons. The study includes three predominantly African American communities in New York, Baltimore, and New Orleans, and enrolls Hispanic sisters primarily from communities in and around San Antonio. All data collection forms have been translated into Spanish. Working with religious communities offers a number of advantages. First, they are altruistic and have a history of participating in research projects from which they may derive little to no personal benefit. Second, they live communally and loss of contact with participants is rare, facilitating the high follow-up and autopsy rates required to ensure internal study validity. Third, their wishes for organ donation are likely to be honored by the Superior and biological family members are unlikely to interfere with the participants’ written preference. Finally, the participants have similar education, socioeconomic and life experiences for most of their adult lives. This allows for tighter control of these potentially confounding variables in analyses of incident AD and cognitive decline.
The study design (Figure 2) supports the following analyses in a single dataset: 1) the association of neurobiologic indices with AD, MCI, and cognition proximate to death and over multiple years prior to death; 2) the association of risk factors for incident AD, incident MCI, and cognitive decline; and 3) the modeling of neurobiologic pathways linking risk factors to clinical phenotypes. The collection of parkinsonian signs and other measures of motor function allow for similar analyses to be conducted with motor function and decline, and disability.
Bennett D.A., Schneider J.A., Arvanitakis Z, & Wilson R.S. (2012). OVERVIEW AND FINDINGS FROM THE RELIGIOUS ORDERS STUDY. Current Alzheimer research, 9(6), 628-645.
Publication 2012
Adult African American Autopsy Biopharmaceuticals Brain Brothers Cognition Dementia Disabled Persons Disorders, Cognitive Ethics Committees, Research Family Member Hispanic or Latino Hispanics Life Experiences Missionaries Muscle Tissue Nervousness Nuns Organ Transplantation Phenotype Priests Roman Catholics Spinal Cord
4
Mitigating Noise in Resting-State fMRI

Protocol full text hidden due to copyright restrictions

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Publication 2013
Brain Carps Cerebral Ventricles derivatives fMRI Gray Matter Head MRI Scans Nervousness Plant Roots Protein Biosynthesis Reading Frames Tissues White Matter
5
Calcium Deconvolution from Fluorescence Signals
We assume we observe the fluorescence signal for T timesteps, and denote by st the number of spikes that the neuron fired at the t-th timestep, t = 1, …, T, cf. Fig 1. Following [5 (link), 13 (link)], we approximate the calcium concentration dynamics c using a stable autoregressive process of order p (AR(p)) where p is a small positive integer, usually p = 1 or 2,
ct=∑i=1pγict-i+st.
The observed fluorescence y∈ℝT is related to the calcium concentration as [5 (link)–7 ]:
yt=act+b+ϵt,ϵt∼N(0,σ2)
where a is a non-negative scalar, b is a scalar offset parameter, and the noise is assumed to be i.i.d. zero mean Gaussian with variance σ2. For the remainder we assume units such that a = 1 without loss of generality. We begin by assuming b = 0 for simplicity, but we will relax this assumption later. (We also assume throughout that all parameters in sight are fixed; in case of e.g. drifting baselines b we could generalize the algorithms discussed here to operate over shorter temporal windows, but we do not pursue this here.) The parameters γi and σ can be estimated from the autocovariance function and the power spectral density (PSD) of y respectively [13 (link)]. The autocovariance approach assumes that the spiking signal s comes from a homogeneous Poisson process and in practice often gives a crude estimate of γi. We will improve on this below by fitting the AR coefficients directly, which leads to better estimates, particularly when the spikes have some significant autocorrelation.
The goal of calcium deconvolution is to extract an estimate s^ of the neural activity s from the vector of observations y. As discussed in [5 (link), 13 (link)], this leads to the following non-negative LASSO problem for estimating the calcium concentration:
minimizec^,s^12∥c^-y∥2+λ∥s^∥1subject tos^=Gc^≥0
where the ℓ1 penalty on s^ enforces sparsity of the neural activity and the lower triangular matrix G is defined as:
G=10⋯⋯⋯⋯0-γ11⋱⋱⋱⋱0⋮⋱⋱⋱⋱⋱⋮-γp⋯-γ110⋯00-γp⋯-γ11⋱0⋮⋱⋱⋱⋱⋱⋮0⋯0-γp⋯-γ11.
The deconvolution matrix G is banded with bandwidth p for an AR(p) process. Equivalently, s = c * g with g a finite impulse response filter of order p (p + 1 filter taps) and * denoting convolution. To produce calcium trace c, spike train s is filtered with the inverse filter of g, an infinite impulse response h, c = s * h. (Although our main focus is on the autoregressive model, we will discuss more general convolutional observation models below as well, and touch on nonlinear effects such as saturation in the Appendix.) Following the approach in [5 (link)], note that the spike signal s^ is relaxed from non-negative integers to arbitrary non-negative values.
Friedrich J., Zhou P, & Paninski L. (2017). Fast online deconvolution of calcium imaging data. PLoS Computational Biology, 13(3), e1005423.
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Publication 2017
BaseLine dental cement Calcium Cloning Vectors Fluorescence Nervousness Neurons Touch Vision

Most recents protocols related to «Nervousness»

1
Renal Nerve Ablation: Sympathetic Reduction
Not available on PMC !

Example 1

This section describes an example of the outcome of renal neuromodulation on human patients. A total of 45 patients (mean age of 58±9 years) diagnosed with essential hypertension were treated with percutaneous, catheter based renal nerve ablation. Treatment included RF energy delivery to the renal artery using a single-electrode Symplicity Flex™ catheter commercially available from Medtronic, Inc., of 710 Medtronic Parkway, Minneapolis, Minnesota 55432-5604. In this human trial, a radiotracer dilution method was used to assess overflow of norepinephrine from the kidneys into circulation before and 15-30 days after the procedure in 10 patients. Bilateral renal-nerve ablation resulted in a marked reduction in mean norepinephrine spillover from both kidneys: 47% (95% confidence interval) one month after treatment.

In a similar human trial where bilateral renal nerve ablation was performed in 70 patients, whole-body norepinephrine levels (i.e., a measure of “total” sympathetic activity), fell by nearly 50% after renal nerve ablation and measurement of muscle sympathetic nerve activity showed a drop of 66% over 6 months, further supporting the conclusion that total sympathetic dive was reduced by the renal denervation procedure in this patient group.

US11865343B2. Methods for treating post-traumatic stress disorder in patients via renal neuromodulation (2024-01-09). Medtronic Ireland Manufacturing Unlimited Company [IE]. Inventors: Marcia Gallagher [IE], Douglas A. Hettrick [US].
Full text: Click here
Patent 2024
Aftercare Catheter Ablation, Percutaneous Catheters Essential Hypertension Homo sapiens Human Body Kidney Muscle Denervation Muscle Tissue Nervousness Norepinephrine Obstetric Delivery Patients Post-Traumatic Stress Disorder Renal Artery Renal Circulation Technique, Dilution
2
Personalized Nerve Stimulation for Pain and Muscle Performance
Not available on PMC !

Example 10

The nerve of muscle stimulator is used for reducing pain, or for improving muscle performance, works via a closed loop, which comprises personalized variability pattern(s) with or without additional data from the subject, other non-variable parameters, and data from other subjects. It improves the effect of the device for reducing acute or chronic pain and muscle performance.

US11881296B2. Identifying and quantifying individualized variability-patterns and implementing them for improved efficacy of systems (2024-01-23). OBERON SCIENCES ILAN LTD. [IL]. Inventors: Yaron Ilan [IL].
Full text: Click here
Patent 2024
Chronic Pain Medical Devices Muscle Tissue Nervousness Pain
3
Invasive Knee Joint Tracking Protocol
Not available on PMC !

Example 1

Provided herein is an exemplary embodiment of workflow for tracking and registering a knee joint using markers that are drilled into the in tibia and femur of the knee joint in the patient and protrude out from their placement site. The placement of the marker in order to track and register the bones of the knee joint is an invasive procedure that damages the tissue at and around the knee joint. The marker is used in marker-based tracking to track and register the knee joint and in robot-assisted surgical systems. Such invasive fixation of markers to bones may lead to complications, infections, nerve injury, and bone fracture. The marker fixation may reduce the flexibility during the procedure as the protruding markers may get in the way during the procedure. The surgical procedure may take longer to fix the marker into place than a markerless approach.

US11857271B2. Markerless navigation using AI computer vision (2024-01-02). Future Health Works Ltd. [GB]. Inventors: Thomas Harte [GB], Huy Quoc Phan [GB].
Full text: Click here
Patent 2024
Bones Femur Fracture, Bone Infection Injuries Knee Joint Nervousness Operative Surgical Procedures Patients Robotic Surgical Procedures Tibia Tissues
4
Epidural Injection Distribution Pattern Evaluation
Prior to administration, the data regarding the demographic characteristics, such as, pain duration, pain severity, and involved nerve root were extracted. Two radiologists retrospectively analyzed and recorded the IDP on postintervention CT scanning images. The injection spread patterns in the cross-sectional CT images included the following: Zone I: extra-foraminal; Zone II: the foraminal spaces; Zone III: intra-foraminal (Figure 3).

The injection distribution area in the cross section of CT image: Line A is from anterolateral vertebral body to the lateral margin of the facet. Line B is from posterior-lateral vertebral body to the interior margin of the facet. Line C is the axial centerline of the epidural space. Zone I The out space of line A is extra-foraminal; Zone II: Between line A and B is the foraminal spaces; Zone III: Between line B and C is intra-foraminal/epidural spaces.

An investigator blinded to the patient assignments/treatments performed patient follow-ups, and recorded pain scores, particularly, NRS during hospital visits at 2 hours, 1 week, and 4 weeks after injection.
Safety was assessed as follows: ① Bleeding situation: Prior to drug injection, we recorded whether there was blood upon withdrawal, and verified the presence or absence of hematoma via CT scan. ② Other adverse reactions, including, puncture point pain, shortness of breath, paresthesias, motor deficit, hematoma, dizziness, headache, vomiting, general spinal anesthesia, and so on.
Ma L., Wang Y., Yao M., Huang B., Deng J, & Wen H. (2023). Evaluating the Extent of Ultrasound-Guided Cervical Selective Nerve Root Block in the Lower Cervical Spine: Evidence Based on Computed Tomography Images. Journal of Pain Research, 16, 669-676.
Publication 2023
BLOOD Dyspnea General Anesthesia Headache Hematoma Nervousness Pain Paresthesia Patients Pharmaceutical Preparations Plant Roots Punctures Radiologist Safety Severity, Pain Spaces, Epidural Vertebral Body X-Ray Computed Tomography
5
Preprocessing and ALFF Analysis of fMRI Data
Preprocessing of all functional images was performed using SPM12 (www.fil.ion.ucl.ac.uk/spm/) and DPARSF [31 (link)]. The first 10 time points were discarded for magnetic field stabilization and allowing participants to adapt to the scanning environment. The subsequent preprocessing steps included slice time correction and head motion correction. Each participant’s motion was assessed by means of translation/rotation, and an exclusion criterion (translation > 3 mm, rotation > 3° in each direction) was set. Next, the corrected functional images were normalized to MNI space using the EPI template in SPM12, resampled to 3 mm isotropic voxels, and further smoothed via a Gaussian kernel with a 6 mm full-width at half-maximum. Linear detrending was also performed. Finally, voxel-wise ALFF (0.01–0.08 Hz) maps were calculated for each participant. ALFF (0.01–0.08 Hz) of the BOLD signal, which is considered to be physiologically meaningful and related to regional spontaneous neural activity [32 (link)], was used to identify regional cerebral function.
Duan J., Gong X., Womer F.Y., Sun K., Tang L., Liu J., Zheng J., Zhu Y., Tang Y., Zhang X, & Wang F. (2023). Neurodevelopmental trajectories, polygenic risk, and lipometabolism in vulnerability and resilience to schizophrenia. BMC Psychiatry, 23, 153.
Full text: Click here
Publication 2023
Head Magnetic Fields Microtubule-Associated Proteins Nervousness

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More about "Nervousness"

Nervousness, also known as anxiety or apprehension, is a common emotional state characterized by feelings of tension, worry, and unease.
Often associated with physical symptoms such as increased heart rate, sweating, and trembling, effective management of nervousness can improve research outcomes and reproducibility.
Researchers investigating nervousness may utilize a variety of cell culture techniques and supplements to create optimal conditions for their experiments.
DMEM/F12 is a widely used cell culture medium that provides essential nutrients, while GlutaMAX and N2 supplement help support neuronal cell growth and differentiation.
Penicillin/streptomycin are commonly added antibiotics to prevent bacterial contamination, and B27 supplement is often used to promote the survival and maturation of neurons.
For neural stem cell and progenitor cell cultures, Neurobasal medium is a popular choice, supplemented with B27, L-glutamine, and basic fibroblast growth factor (bFGF) to maintain an undifferentiated state and enhance proliferation.
Fetal bovine serum (FBS) is also a common additive, providing growth factors and other essential components.
By carefully selecting and optimizing these cell culture components, researchers can create a supportive environment for studying the underlying mechanisms and potential treatments related to nervousness and anxiety disorders.
PubCompare.ai's AI-driven platform can help identify the most effective protocols and products to ensure accurate and reliable results in nervousness research, ultimately contributing to improved understanding and management of this common emotional state.