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Rats, Inbred WKY

Inbred Wistar-Kyoto (WKY) rats are a widely used animal model for studying cardiovascular and neurological disorders.
This strain is characterized by its genetic stability, making it a reliable choice for reproducible research.
PubCompare.ai's AI-driven tool can help locate the best inbred WKY protocols from literature, preprints, and patents, enhancing the reproducibility of your rat studies.
The platform compares protocols and products, allowing you to identify the most reliable options for your research and streamline your rat experiments.

Most cited protocols related to «Rats, Inbred WKY»

1
Cortical Activity Dynamics in Rats
Cited 15 times
In male WKY rats, local field potentials (LFPs) and multiunit activity (MUA) were recorded from deep layers of frontal (n=11 rats) and/or parietal (n=9) cortex with 16-ch (2×8) polyimide-insulated tungsten microwire arrays. Rats were housed individually in transparent Plexiglas cages (light:dark 12:12, light on at 10am, 23±1°C; food and water ad libitum and replaced daily at 10am, except for the sugar pellet reaching task; see Supplementary Information). Animal protocols followed the National Institutes of Health Guide for the Care and Use of Laboratory Animals and were in accordance with institutional guidelines.
Data acquisition and online spike sorting were performed with the Multichannel Neurophysiology Recording and Stimulation System (Tucker-Davis Technologies Inc., TDT). MUA was collected continuously (25 kHz, 300 Hz – 5 kHz), concomitantly with the LFPs from the same electrodes and epidural EEGs (both 256 Hz, 0.1–100 Hz). Amplitude thresholds for online spike detection were set manually and allowed only crossings of spikes below −25uV. LFP power spectra were computed by a Fast Fourier Transform (FFT) routine for 4-sec epochs (Hanning window, 0.25 Hz resolution). Sleep stages were scored off-line by visual inspection of 4-sec epochs, where the EEG, LFP, EMG and spike activity were displayed. Spike sorting was performed by PCA followed by SMEM clustering algorithm. Population OFF periods in wake and NREM sleep were defined as periods with suppressed or absent neuronal activity. Recordings were performed continuously for 2–3 weeks. In each animal 2–4 experiments (at least 5 days apart) with 4h of sleep deprivation were performed, one of which combined with the sugar pellet reaching task. For details about the analysis of firing rates and neuronal population OFF periods, see Supplementary Information.
Vyazovskiy V.V., Olcese U., Hanlon E.C., Nir Y., Cirelli C, & Tononi G. (2011). Local sleep in awake rats. Nature, 472(7344), 443-447.
Publication 2011
Animals Animals, Laboratory Carbohydrates Cortex, Cerebral EPOCH protocol Food Light Males Neurons Plexiglas Rats, Inbred WKY Rattus Sleep, Slow-Wave Sleep Stages Tungsten
2
Murine Models of Cardiac Hypertrophy
Cited 13 times
All experiments involving animals conformed to the Guide for the Care and Use of Laboratory Animals published by the US National Institutes of Health (NIH Publication 8th edition, update 2011) and were approved by the Institutional Animal Care and Use Committee of the University of Texas Southwestern Medical Center. The studies were in compliance with all ethical regulations. C57BL/6N mice were used for wild-type (WT) studies. Tetracycline responsive elements (TRE)-Xbp1s mice were crossed with mice harbouring tetracycline transactivator (tTA) transcription factor driven by α-myosin heavy chain promoter (αMHC-tTA) to generate mice with cardiomyocyte-specific inducible overexpression of Xbp1s (Xbp1s TG) as previously described10 (link). iNOS knockout mice (Nos2−/−, B6.129P2-Nos2tm1Lau/J) were purchased from Jackson Laboratory (Bar Harbor, Maine) to establish an in-house colony. ZSF1-obese (ZSF1-LeprfaLeprcp/Crl, strain code 378) and Wistar-Kyoto (WKY) rats were obtained from Charles River Laboratories (Wilmington, Massachusetts). Male adult (8/12 week-old) mice were used in the experiments. Analyses in rats were carried out when the animals reached 20 weeks of age. Mice and rats were maintained on a 12-hour light/dark cycle from 6 AM to 6 PM and had unrestricted access to food (#2916, Teklad for CHOW groups and D12492, Research Diet Inc. for the HFD groups) and water. N[w]-nitro-l-arginine methyl ester (L-NAME; 0.5 g/L, Sigma Aldrich) was supplied in the drinking water for the indicated periods of time, after adjusting the pH to 7.4. L-N6-(1-iminoethyl)lysine (L-NIL, Cayman Chemical) was administered intraperitoneally (i.p.) at a dose of 80 mg/kg body weight twice a day for three days. Transverse aortic constriction (TAC or severe TAC, sTAC) was surgically induced as previously described24 (link).
Schiattarella G.G., Altamirano F., Tong D., French K.M., Villalobos E., Kim S.Y., Luo X., Jiang N., May H.I., Wang Z.V., Hill T.M., Mammen P.P., Huang J., Lee D.I., Hahn V., Sharma K., Kass D.A., Lavandero S., Gillette T.G, & Hill J.A. (2019). Nitrosative Stress Drives Heart Failure with Preserved Ejection Fraction. Nature, 568(7752), 351-356.
Publication 2019
Adult Animals Animals, Laboratory Aortic Valve Stenosis arginine methyl ester Body Weight Caimans Diet Food Institutional Animal Care and Use Committees Lysine Males Mice, House Mice, Inbred C57BL Mice, Knockout Myocytes, Cardiac Myosin Heavy Chains NG-Nitroarginine Methyl Ester Nitric Oxide Synthase Type II NOS2A protein, human Obesity Operative Surgical Procedures Rats, Inbred WKY Rattus norvegicus Rivers Strains Tetracycline Trans-Activators Transcription Factor
3
Exercise and Hypertension in Rats
Cited 11 times
Seven week old male normotensive Wistar-Kyoto (WK) and spontaneously hypertensive (SHR) rats were randomly assigned either to the sedentary group (SHRsed; n=10 and WKsed; n=10) or to the exercise group (SHRex; n=10 and WKex; n=10). Exercise groups were subjected to moderate-intensity exercise on a motor-driven treadmill continuously for a period of 16 weeks. Animals were euthanized twenty-four hours after the last exercise session at the age of 23 weeks and left ventricle (LV) tissues were collected for later analyses. We performed the following experimental procedures: blood pressure measurements, echocardiographic analysis, real time RT-PCR, western blot analysis, electron paramagnetic resonance (EPR) studies, antioxidant assays, electrophoretic mobility shift assay (EMSA), reverse-phase high-performance liquid chromatography (HPLC), ELISA, and statistical analysis.
Agarwal D., Haque M., Sriramula S., Mariappan N., Pariaut R, & Francis J. (2009). Role of Proinflammatory Cytokines and Redox Homeostasis in Exercise-Induced Delayed Progression of Hypertension in Spontaneously Hypertensive Rats. Hypertension, 54(6), 1393-1400.
Publication 2009
Animals Antioxidants Biological Assay Chromatography, Reversed-Phase Liquid Determination, Blood Pressure Echocardiography Electron Spin Resonance Spectroscopy Electrophoretic Mobility Shift Assay Enzyme-Linked Immunosorbent Assay Left Ventricles Males Rats, Inbred SHR Rats, Inbred WKY Real-Time Polymerase Chain Reaction Tissues Western Blot
4
Substance P Antagonist Attenuates Hypertension
Cited 7 times

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Publication 2013
Anesthesia Animals Animals, Laboratory Blood Pressure Blood Vessel Dietary Supplements Esophagectomy Euthanasia Formalin Freezing Heart Heart Atrium High Blood Pressures Institutional Animal Care and Use Committees Isoflurane Left Ventricles Lung Myocardium Nitrogen Pharmaceutical Preparations Pleura Rats, Inbred WKY Substance P Substance P Receptor Tail Trachea Ventricles, Right
5
Behavioral Testing of Depressive-like Phenotype
Cited 6 times

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Publication 2014
Anhedonia Animals Behavior Test Food Locomotion Pharmaceutical Preparations Rats, Inbred WKY Rattus norvegicus Strains Sucrose Tail Touch

Most recents protocols related to «Rats, Inbred WKY»

1
High-Salt Diet-Induced Hypertension in SHR
A total of seven-week-old male SHR and Wistar Kyoto rats (WKY) weighing 200-250 g were obtained from Shanghai Laboratory Animal Center of the Chinese Academy of Science (Shanghai, China), and received humane care in compliance with the Guide for the Care and Use of Laboratory Animals (NIH Pub. no. 85-23, revised 1996), which was approved by the Institutional Ethics Review Board of the Characteristic Medical Center of the Chinese People's Armed Police Forces (Tianjin, China; approval number: 2012-0005). Rats were maintained in a 12/12-h dark/light cycle in air-conditioned rooms (23±1˚C, 55±5% humidity) and were acclimated to the local conditions for 1 week before the study. At 8 weeks of age, rats were divided randomly (n=12 for each group), and then given either a low-salt (LS; 0.5% NaCl) or HS diet (8% NaCl) for 8, 12 or 16 weeks. All rats were permitted free access to chow and tap water.
Bi Y., Yang G.H., Guo Z.Z., Cai W., Chen S.B., Zhou X, & Li Y.M. (2023). Chronic high‑salt intake induces cardiomyocyte autophagic vacuolization during left ventricular maladaptive remodeling in spontaneously hypertensive rats. Experimental and Therapeutic Medicine, 25(4), 148.
Publication 2023
Animals, Laboratory Chinese Humidity Males Military Personnel Rats, Inbred WKY Rattus norvegicus Sodium Chloride Sodium Chloride, Dietary Therapy, Diet
2
Hypertensive Rat Model Interventions
In this study, 12 male normotensive Wistar Kyoto rats (WKY/NCrl) and 36 male spontaneously hypertensive rats (SHR/NCrl) were used. Hypertensive rats were randomly allocated to three different experimental groups: 12 untreated rats (SHR Ctrl), 12 rats treated with amlodipine (SHR Amlo), and 12 rats treated with atenolol (SHR Aten). WKY rats were left untreated and served as a normotensive control group (WKY Ctrl). One untreated SHR and one atenolol-treated SHR died during the study from unknown causes, leaving 11 rats in both of these groups. All animals were obtained from Charles River (Germany) and were 4 weeks of age upon arrival in the animal facility. They were housed in groups of 2 rats per cage on a 12-h light/12-h dark schedule and had ad libitum access to standard laboratory food and drinking water. All experiments were performed in a blinded fashion and were in accordance with the ARRIVE guidelines and European Union guidelines for the welfare of laboratory animals (Directive 2010/63/EU), and were approved by the Academic Medical Center Animal Ethics Committee. All in vivo experiments were carried out under isoflurane inhalation anaesthesia (Pharmachemie B.V.).
Naessens D.M., de Vos J., Richard E., Wilhelmus M.M., Jongenelen C.A., Scholl E.R., van der Wel N.N., Heijst J.A., Teunissen C.E., Strijkers G.J., Coolen B.F., VanBavel E, & Bakker E.N. (2023). Effect of long-term antihypertensive treatment on cerebrovascular structure and function in hypertensive rats. Scientific Reports, 13, 3481.
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Publication 2023
Amlodipine Anesthesia, Inhalation Animal Ethics Committees Animals Animals, Laboratory Atenolol Food Isoflurane Light Males Rats, Inbred SHR Rats, Inbred WKY Rattus norvegicus Rivers
3
Behavioral and Amino Acid Analysis in Rats
All data are expressed as mean with SEM. Body weight was analyzed by a repeated-measures three-way ANOVA. The number of center zone entries and total distance in the OFT, the total duration of immobility in the FST, and free amino acid concentrations were analyzed using three-way ANOVA; significance was set at p < 0.05. Multiple regression analysis was applied to the OFT and FST for the variables of parental strain and sex of pups (strain: WIS rat =1, WKY rat = 2, sex: male =1, female = 2). All analyses were performed with StatView (version 5, SAS Institute Cary, USA, SAS, 1998). Outlying data from the behavioral tests and amino acid analysis were eliminated using Thompson’s test criterion for outlying observations (p < 0.01). Although several combinations of interactions were determined, only interactions indicating significant effects are provided in the relevant tables and figures.
Ihara T., Hamada M, & Furuse M. (2023). The Greater Impact of Paternal, Compared to Maternal, Hereditary Background on Depressive-Like Behavior in Wistar Kyoto Rats with Different Amino Acid Metabolism in the Pup Brain. International Journal of Molecular Sciences, 24(4), 4199.
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Publication 2023
Amino Acids Behavior Test Body Weight Females Males neuro-oncological ventral antigen 2, human Parent Rats, Inbred WKY Strains
4
Rat Strain Comparison in Controlled Environment
Seven-week-old WIS (6 female and 6 male) and WKY rats (6 female and 6 male) (Charles River Japan, Yokohama, Japan) were examined. Rats were housed 3 per cage with free access to a standard diet for laboratory rodents (MF, Oriental Yeast, Tokyo, Japan) and water. A 12 h light/dark cycle (lights on at 08:00, lights off at 20:00), a room temperature of 23 °C, and humidity of 60% were maintained throughout the study. The study was performed according to the guidelines for Animal Experiments in the Faculty of Agriculture and in the Graduate Course of Kyushu University (A28-184-1), and in accordance with Law No. 105 and Notification No. 6 of the government of Japan.
Ihara T., Hamada M, & Furuse M. (2023). The Greater Impact of Paternal, Compared to Maternal, Hereditary Background on Depressive-Like Behavior in Wistar Kyoto Rats with Different Amino Acid Metabolism in the Pup Brain. International Journal of Molecular Sciences, 24(4), 4199.
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Publication 2023
Asian Persons Diet Faculty Females Humidity Light Males Rats, Inbred WKY Rattus Rivers Rodent Yeast, Dried
5
Antihypertensive Therapies in Spontaneously Hypertensive Rats
Six-week-old male SHRs (130–150 g) and five-week-old male Wistar Kyoto (WKY) rats (130–150 g) were obtained from Charles River, Inc (Beijing, China, SCXK (Jing) 2016-0006). All animals were housed under controlled light (12 h/12 h light–dark cycle), humidity 55% ± 5% and temperature 22.1 °C ± 0.5 °C with free access to water and standard chow. There was one week of adaptive feeding before the formal experiment. All experimental procedures were approved by the Biological and Medical Ethics Committee, Minzu University of China (approval No. ECMU201807).
A total of 32 SHRs were divided into 4 groups: SHR-M (double-distilled water), SHR-Losartan (SHR-Los, 20 mg/kg/day) [79 (link)], SHR-Aspirin (SHR-Asp, 10 mg/kg/day) [80 (link)], and SHR-Atorvastatin (SHR-Ato, 10 mg/kg/day) [81 (link)]. All these drugs were dispersed in double-distilled water and were administrated daily to SHRs via oral gavage for 16 weeks. WKY rats were treated with double-distilled water as normotensive controls.
Liu Q., Dong S., Zhou X., Zhao Y., Dong B., Shen J., Yang K., Li L, & Zhu D. (2023). Effects of Long-Term Intervention with Losartan, Aspirin and Atorvastatin on Vascular Remodeling in Juvenile Spontaneously Hypertensive Rats. Molecules, 28(4), 1844.
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Publication 2023
Acclimatization Animals Aspirin Atorvastatin Biopharmaceuticals Ethics Committees Humidity Light Losartan Males Pharmaceutical Preparations Rats, Inbred WKY Rivers SHORT ROOT protein, Arabidopsis Tube Feeding

Top products related to «Rats, Inbred WKY»

1
Wistar kyoto wky rats by Charles River Laboratories
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The Wistar-Kyoto (WKY) rats are a well-established and widely used laboratory animal model. They are inbred rats derived from the Wistar rat strain. WKY rats are commonly used in research to study various physiological and behavioral processes.
2
Wistar kyoto rats by Charles River Laboratories
Sourced in United States, China, Germany
Wistar Kyoto rats are an inbred strain of laboratory rats commonly used in research. They are genetically stable and have well-characterized physiological and behavioral characteristics.
3
Wky rats by Charles River Laboratories
Sourced in China, Canada, United States, Japan
The WKY rats are an inbred strain of rats developed at the Wistar Institute. They are commonly used as a control or reference strain in research studies. The WKY rats exhibit normal physiological and behavioral characteristics.
4
Male wistar kyoto wky rats by Charles River Laboratories
Sourced in United States, China
Male Wistar-Kyoto (WKY) rats are an inbred strain of laboratory rats. They are commonly used as a reference or control strain in research studies. The WKY rat is characterized by its genetic uniformity and stability, making it a reliable model for various scientific investigations.
5
Fetal bovine serum (fbs) by Thermo Fisher Scientific
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Fetal Bovine Serum (FBS) is a cell culture supplement derived from the blood of bovine fetuses. FBS provides a source of proteins, growth factors, and other components that support the growth and maintenance of various cell types in in vitro cell culture applications.
6
Shr ncrl by Charles River Laboratories
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The SHR/NCrl is a laboratory animal model produced by Charles River Laboratories. It is a spontaneously hypertensive rat strain that can be used for research purposes. The core function of this product is to provide a model for the study of hypertension and related cardiovascular conditions.
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Wistar kyoto by Charles River Laboratories
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The Wistar-Kyoto is a laboratory rat strain used in research. It is a widely used model for studying various biological processes and disease conditions. The Wistar-Kyoto strain is characterized by its genetic and physiological characteristics, which make it a valuable tool for scientific investigations.
9
Wistar kyoto wky by Charles River Laboratories
Sourced in United States
The Wistar Kyoto (WKY) is a laboratory rat strain developed at the Wistar Institute. It is a widely used control strain for various animal studies. The WKY rat exhibits normal physiological and behavioral characteristics and is often used as a reference to compare the effects of experimental interventions in related rat models.
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DMSO is a versatile organic solvent commonly used in laboratory settings. It has a high boiling point, low viscosity, and the ability to dissolve a wide range of polar and non-polar compounds. DMSO's core function is as a solvent, allowing for the effective dissolution and handling of various chemical substances during research and experimentation.

More about "Rats, Inbred WKY"

Rats, particularly the Inbred Wistar-Kyoto (WKY) strain, are a widely utilized animal model for cardiovascular and neurological research.
This genetically stable strain is renowned for its reliability and reproducibility, making it a preferred choice for scientists studying various disorders.
The Wistar-Kyoto (WKY) rats, also known as Wistar Kyoto rats or WKY rats, are characterized by their genetic uniformity, which allows for consistent and reliable research outcomes.
Male Wistar-Kyoto (WKY) rats are commonly used in these studies, as they provide a stable and well-established model for investigating cardiovascular and neurological conditions.
To enhance the reproducibility of rat studies, PubCompare.ai's AI-driven tool can be invaluable.
This platform allows researchers to easily locate the best inbred WKY protocols from literature, preprints, and patents, streamlining the experimental process and improving the reliability of their findings.
In addition to WKY rats, researchers may also utilize other related models, such as SHR/NCrl (Spontaneously Hypertensive Rats) and Wistar-Kyoto, in their investigations.
These strains can provide complementary insights and help expand the understanding of various disease mechanisms.
Researchers can also explore the use of FBS (Fetal Bovine Serum) and DMSO (Dimethyl Sulfoxide) in their rat studies, as these substances may play a role in cell culture and preservation techniques.
By leveraging the insights and tools provided by PubCompare.ai, scientists can streamline their rat experiments, enhance the reproducibility of their research, and gain deeper insights into cardiovascular and neurological disorders.
This powerful platform is a valuable resource for researchers working with the Inbred Wistar-Kyoto (WKY) rat model and related strains.