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Alcoholics

Alcoholics are individuals who are addicted to alcohol, a psychoactive substance that can have detrimental effects on physical and mental health.
This condition is characterized by a strong craving for alcohol, an inability to control its consumption, and continued use despite negative consequences.
Alcoholism is a complex disorder that is influenced by genetic, psychological, and social factors.
It can lead to a variety of health problems, including liver disease, cognitive impairment, and an increased risk of accidental injury or death.
Effectivbe treatment options for alcoholics include behavioral therapies, medication, and support from peers and healthcare professionals.
With the right interventions, many alcoholics are able to achieve and maintain sobriety, improving their overall quality of life.

Most cited protocols related to «Alcoholics»

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Publication 2014
Alcoholics Alcohol Use Disorder Diagnosis Eating Disorders Ethnicity Feeding Behaviors Pharmaceutical Preparations Quercus Substance Use
The most broadly useful contrast stains tested so far are inorganic iodine and phosphotungstic acid (PTA)[22 (link)]. The formulations and general procedures used are given in Table 2, and notes on the fixatives used are in Table 3[23 -25 (link)]. The stains and procedures are simple and the procedures are robust. The staining times were found not to be critical, as long as the stain had sufficient time to penetrate the tissues. Inorganic iodine in alcoholic or aqueous solution diffuses rapidly into fixed tissues and was able to stain most specimens in a few hours or less, although staining was generally done overnight. PTA is a much larger molecule [26 (link)], and the solution used here was found to require overnight incubation to penetrate specimens 2–3 mm thick, and longer for larger specimens. PTA is known to bind heavily to various proteins and connective tissue [27 ,28 ], and this property, along with electron-shell energies that match common x-ray source emissions, suggested that it might be a useful stain for x-ray imaging. A few samples were tested with phosphomolybdic acid (PMA) staining, used similarly to PTA. The results (not shown) were generally similar, and PMA was not pursued further here (but see refs. [29 (link)] and [30 ] for successful application of PMA).
Publication 2009
Alcoholics Connective Tissue Electrons Fixatives Iodine phosphomolybdic acid Phosphotungstic Acid Proteins Radiography Stains Tissues
The programming details of the induction phase include the designation of 3 experimental “States” for each session, imposed to separate the induction of ethanol drinking from the consumption of water and food later in the daily session. In “State 1” (scheduled-induced polydipsia) a food pellet was given every 300 seconds until the predetermined amount of fluid was consumed (or the daily food ration of pellets was delivered). “State 2” then ensued without pellet delivery and only vehicle (water) was available for 2 hours. However, if the induced dose of ethanol was not consumed in state 1 (an occurrence that would also indicate the entire daily food ration had been delivered under the fixed-time schedule), then ethanol remained the only fluid available in state 2 (this occurred in 5/900 or <0.5% of total ethanol induction sessions). “State 3” then began and any remaining pellets (daily ration minus pellets delivered under the fixed-time schedule) were available under a fixed ratio of 1 pellet for each press on the push panel. Water was also available. The preset volume of the induced fluid was completely consumed in either state 1 or state 2 in all, but 1 monkey on 1 day.
The main correlate of current study is daily ethanol intake (g/kg) during the 12-months of ethanol self-administration for 22 h/d (further details and characteristics of the 12 months of chronic ethanol self-administration to be published separately). Two sets of exploratory analyses, namely, principal components regression analysis (PCRA) and classification based on functional principal components analysis (FPCA), were performed to determine whether drinking behaviors on different induction doses (water, 0.5, 1.0, and 1.5 g/kg sessions) predict chronic alcoholic binge-drinker during 22-hour self-administration.
Publication 2008
Alcoholics Ethanol Food Monkeys Neoplasm Metastasis Obstetric Delivery Pellets, Drug Polydipsia Self Administration Water Consumption
Generation of items: The 35 items from the CEBQ were changed from the “My child …” format to a self-complete “I ...” format (e.g. “My child loves food” was changed to “I love food”) and the original response options (‘never’, ‘rarely’, ‘sometimes’, ‘often’ and ‘always’) were retained. Ten researchers working in the area of Energy Balance completed the self-report version of the CEBQ and discussed their experiences. The researchers described how the Desire to Drink scale was difficult to complete. Items from the CEBQ such as “My child is always asking for a drink” had been adapted to “I am always asking for a drink” for the AEBQ and it became unclear what type of drink (i.e. alcoholic versus non-alcoholic) was being referred to. Additionally, the item “My child is always asking for food” from the FR construct in the CEBQ, which became “I am always asking for food” in the AEBQ, was difficult for adults to relate to. It was therefore agreed that the 3 items from the Desire to Drink scale, and the “I am always asking for food item” from the FR scale should be eliminated.
Further refinement of the questionnaire took place in 3 group discussions with a panel of clinical psychologists, behavioural scientists, dieticians, and authors of the original CEBQ. The panel initially reviewed the remaining items from the original CEBQ for any obvious gaps or additional problem areas. It was suggested that a measure of hunger experience (H), which could not be captured by the CEBQ because parents are unable to accurately determine their child’s experienced level of hunger, should be added (Wardle et al., 2013 ). It was also agreed that aspects of Food Responsiveness that related to food cues a parent would not have been able to comment on should also be included. Following this discussion, potential items for the Hunger scale were identified for review, and additional items for the Food Responsiveness scale were developed by the authors for piloting. Finally the panel reviewed all included and excluded items to ensure no further additions/removals were felt to be required. A group consensus was reached and the total number of items following these additions, and the removal of the Desire to Drink scale, was 49.
Piloting. The extended version of the AEBQ was piloted online in an opportunity sample of 49 adults (21–73 years old), 36 women (79.6%) and 13 men (20.4%). Colleagues at University College London were asked to circulate a link to the questionnaire to their friends and family from a range of professional backgrounds. Participants were invited to comment on each individual item and on the questionnaire as a whole. Piloting led to changes in the response options from ‘never’, ‘rarely’, ‘sometimes’, ‘often’ and ‘always’, to ‘strongly disagree’, ‘disagree’, ‘neither agree not disagree’, ‘agree’ and ‘strongly agree’ because participants commented that the original response options did not fit with the questions. The new response options were tested with a small convenience sample (two females and three males, aged 31 ± 7 years). This answer format appeared to be more meaningful and better understood by this sample.
Piloting also led to the deletion of the item “Given the choice, I would always have food in my mouth” because several participants commented that it “sounded a bit odd” or was “over the top”. A second item (“I am interested in food”) was eliminated because participants reported they found the meaning ambiguous. The remaining 47 item version of the AEBQ was included in the Principal Component Analysis (PCA).
Publication 2016
Adult Alcoholics Child Deletion Mutation Dietitian Feelings Females Food Food Additives Friend Hunger Love Males Oral Cavity Parent Woman
We recruited 89 problem drinkers with an AUD diagnosis seeking help to reduce drinking. In order to represent the three theoretically distinct elements of MI, three conditions were created: MI, MI without directive or technical elements (SOMI), and a self-change control (SC). All participants received feedback (see description below) from a research assistant (RA) following assessment and were then randomly assigned to condition. Because of the pilot nature of the study and because participants had a diagnosed AUD and were seeking treatment, treatment and the outcome period were limited to 8 weeks, after which SC participants were offered MI. In addition to standard assessments and the interventions, participants responded to a daily survey delivered via interactive voice recording (IVR). IVR has not been found to be reactive in prior studies (Shiffman, 2009 (link)), but we assessed for potential reactivity as described below. Primary analyses were conducted for the 8 week outcome period. Participants in the therapy conditions were followed for one month after treatment (week 12), and these outcomes are reported.
Publication 2012
Alcoholics

Most recents protocols related to «Alcoholics»

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Example 22

Clinicians can use several biochemical measurements to objectively assess patients' current or past alcohol use. Several more experimental markers hold promise for measuring acute alcohol consumption and relapse. These include certain alcohol byproducts, such as acetaldehyde, ethyl glucuronide (EtG), and fatty acid ethyl esters (FAEE), as well as two measures of sialic acid, a carbohydrate that appears to be altered in alcoholics (Peterson K, Alcohol Research and Health, 2005). Clinicians have had access to a group of biomarkers that indicate a person's alcohol intake. Several of these reflect the activity of certain liver enzymes: serum gamma-glutamyltransferase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and carbohydrate-deficient transferrin (CDT), a protein that has received much attention in recent years. Another marker, N-acetyl-β-hexosaminidase (beta-Hex), indicates that liver cells, as well as other cells, have been breaking down carbohydrates, which are found in great numbers in alcohol (Javors and Johnson 2003).

In some embodiments the disclosed device focuses on detecting markers associated with alcohol abuse from menstrual blood or cervicovaginal fluid.

Patent 2024
Abuse, Alcohol Acetaldehyde Alcoholics Aspartate Transaminase Attention beta-N-Acetylhexosaminidase Biological Markers BLOOD carbohydrate-deficient transferrin Carbohydrates Cells D-Alanine Transaminase enzyme activity Esters Ethanol ethyl glucuronide Fatty Acids gamma-Glutamyl Transpeptidase Hepatocyte Liver Medical Devices Menstruation N-Acetylneuraminic Acid Patients Relapse Serum Staphylococcal Protein A
Fragmented, often abusive early settings characterised by poor relationships with one or both parents characterised participants sense of their place in the world. The family home was frequently associated with experiences of physical, emotional and sexual abuse. With the disruption of formative networks and bonds with caregivers, this culminated for many within institutional care or the care of relatives. Reported experiences of care were mixed, with many women describing “getting in with the wrong crowd” and taking drugs for the first time but also feelings of relief during a respite from abuse at home:

Me mam was a severe alcoholic. I used to get beat up daily. The school didn’t do anything until I was 12-year old, after me nanna died. And basically, I got put with the person who was actually raping me. So I was there for 3 months and the trauma of that, I just couldn’t cope with. So I rebelled at school, and that’s when I got put into […] children’s home. Things started to calm down a little bit there, but I just wanted to be – it sounds stupid – but I wanted to be where my safety net was, where my mam was (Rosie).

Women described the home environment being one where substance misuse and interpersonal conflict were normalized. Trauma was widely experienced, with multiple adverse experiences throughout the life course. Leaving home often occurred as a result of crisis, either the death of a main caregiver or family breakdown. Women described getting into relationships with older men, which provided both a means of escape and in many cases a trap. For Michelle, a relationship initially provided a refuge from her homelife and though the relationship quickly turned sour her mother did not allow her to return home: “I moved out when I was 15 year old I rang me mam crying cos I was miles away from [home …] and she went “you’ve made your bed you lie in it” (Michelle).
Early experiences of abusive family life set future expectations of relationships, where physical violence was normalized and associated with love. Tracy described how unremarkable experiences of violence were, which foreshadowed later relationships:

I was beaten as a child by my father. My mother beat my sister. Never ever hit me. Sides get picked, you get her I get her. And I thought it was how someone showed that they loved you, you know? … I had my nose broken. First my dad. And then boyfriends. There was a competition going on. It becomes a way of life I guess (Tracy).

Early experiences of lack of informal support of parents and extended family; resources that are normative and critical to healthy child development and achievement even into early adulthood [64 (link)] impact these women throughout their lives. Experiencing early trauma, including emotional, physical, and sexual abuse, neglect, parental mental ill-health and/or substance abuse, are all particular risk factors associated with unresolved trauma and long-term homelessness in adulthood [65 (link)].
Publication 2023
Abuse, Physical Alcoholics Catabolism Child Child Development Children's Health Drug Abuse Emotions Extended Family Feelings Life Experiences Mental Health Mothers Nose Parent Pharmaceutical Preparations Physical Examination Safety Sexual Abuse Sound Substance Abuse Woman Wounds and Injuries
The adult worms recovered after 37 days of mouse infection were fixed and stored in Alcohol-Formalin-Acetic Acid (AFA, 95% ethanol, 3% formaldehyde, and 2% glacial acetic acid), at room temperature, and stained with 2.5% chloride carmine, dehydrated in alcoholic series (70, 90%, and absolute), clarified in methyl salicylate with Canadian balsam (1:2), and prepared as whole-mounts (Neves et al., 1998 (link)). We analyzed at least six males and six females recovered from mice infected with schistosomula previously exposed to Smcarm1-, GFP-dsRNA, or untreated, from the three biological replicates.
Computer images (Image Pro Plus, Media Cybernetics), from male and female worms captured by a camera (640/480 pixels, RGB) coupled to a light microscope (BX50, Olympus), were used for morphometric analyses. We evaluated the number and area of testicular lobes, ovary area, presence of tubercles, presence of eggs and vitelline glands, and integrity of the tegument (Neves et al., 2004 (link)).
Whole mounts of male and female worms were also analyzed under confocal laser scanning microscopy (LSM-410, Zeiss) using a 543 nm laser and a BP560-615 IR filter, in reflected mode. We examined male (testicular lobes, seminal vesicle) and female (yolk glands, ovary, uterus, and ootype) reproductive systems, as well as the integrity of the tegument and the shape of the oral and ventral suckers.
Publication 2023
Acetic Acid Adult Alcoholics Alcohols Biopharmaceuticals Carmine Chlorides Eggs Ethanol Females Formaldehyde Formalin Genitalia Helminths Infection Light Microscopy Males methyl salicylate Mice, House Microscopy, Confocal Ovary RNA, Double-Stranded Seminal Vesicles Testis Uterus
The images used to measure AB were those of commercially sold alcoholic and nonalcoholic beverages. For alcoholic beverages, we used images of beer poured into a glass or canned Japanese sake packages, whereas for nonalcoholic beverages, we used images of tea in a plastic bottle or coffee in a cup. Eight combinations of alcoholic and nonalcoholic images were prepared. Two images were presented simultaneously, 1 at the top of the screen and the other at the bottom; each image had a height and width of 256 pixels/inch (Fig. 1). The 8 image stimulus pairs were randomly presented for a total of 128 trials, from which the RT was calculated. Participants were presented with a gaze point placed at the center of the LCD monitor for 500ms and then the 2 target images were presented, with 500ms allowed for image selection (Fig. 2). After the images were displayed, the nonalcoholic image was followed by the probe stimulus “E,” which stands for “Enter.”[16 ] Participants were asked to select the nonalcoholic image and to press the corresponding button.
Publication 2023
Alcoholic Beverages Alcoholics Beer Beverages Coffee Japanese SELL protein, human
Data were double-entered in OpenClinica, cleaned, and exported to STATA 17.0 (StataCorp, College Station, TX, United States) for analysis. Descriptive analysis was used to understand baseline group characteristics. We determined the proportion that became pregnant as the number that tested positive for pregnancy during study follow-up divided by the total number of participants who tested negative for pregnancy at enrollment (i.e., 100% of our study population, by design). To estimate the incidence of pregnancy, we used the Kaplan–Meier technique to estimate the time to test positive for pregnancy after enrollment into the study and presented the estimated incidence rate per 100 person-years. To estimate baseline factors associated with incident pregnancy, we used Poisson regression analysis with robust error variance both for unadjusted and adjusted levels; variables for which the association attained p < 0.15 at the unadjusted level were selected for the multivariable model except for age, which was considered an a priori confounder. We tested for collinearity between the baseline audit score and the question “have you had any alcoholic drink in the past month?” The results showed no collinearity (variance inflation factors <5). However, due to the very small number of participants with the outcome for the high-risk alcohol use category, we did not consider the baseline audit score for the multivariable model. Variables with a p-value <0.05 at multivariable analysis were considered significantly associated with incident pregnancy. Results are presented as adjusted risk ratios (aRR) with p-values and 95% confidence intervals (CIs).
Publication 2023
Alcoholics Pregnancy Pregnancy Tests

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More about "Alcoholics"

Individuals struggling with alcohol addiction, or alcoholism, are known as alcoholics.
This complex disorder is characterized by a strong craving for alcohol, an inability to control its consumption, and continued use despite negative consequences.
Alcoholics face a variety of health issues, including liver disease, cognitive impairment, and an increased risk of accidental injury or death.
Effective treatment options for alcoholics include behavioral therapies, such as cognitive-behavioral therapy and motivational interviewing, as well as medication like naltrexone and disulfiram.
Support from peers, such as through Alcoholics Anonymous, and healthcare professionals can also be crucial in the recovery process.
Researchers studying alcoholism may utilize various laboratory techniques and equipment, such as Whatman No. 1 filter paper for filtration, Alcoholic eosin Y solution for staining, Mayer's hematoxylin for counterstaining, Permount for mounting, and Alkaline lead citrate for staining in electron microscopy.
Instrumental techniques like the JEM-1230 transmission electron microscope and the BX50 microscope, coupled with software like Xcalibur, can provide valuable insights into the cellular and molecular mechanisms underlying alcoholism.
In addition, the use of anhydrous pyridine and No. 1 filter paper may be relevant in the analysis and purification of compounds related to alcohol metabolism and the effects of alcoholism.
By employing these techniques and tools, researchers can enhance their understanding of alcoholism and develop more effective interventions to help individuals overcome this challenging condition.