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Example 22
Clinicians can use several biochemical measurements to objectively assess patients' current or past alcohol use. Several more experimental markers hold promise for measuring acute alcohol consumption and relapse. These include certain alcohol byproducts, such as acetaldehyde, ethyl glucuronide (EtG), and fatty acid ethyl esters (FAEE), as well as two measures of sialic acid, a carbohydrate that appears to be altered in alcoholics (Peterson K, Alcohol Research and Health, 2005). Clinicians have had access to a group of biomarkers that indicate a person's alcohol intake. Several of these reflect the activity of certain liver enzymes: serum gamma-glutamyltransferase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and carbohydrate-deficient transferrin (CDT), a protein that has received much attention in recent years. Another marker, N-acetyl-β-hexosaminidase (beta-Hex), indicates that liver cells, as well as other cells, have been breaking down carbohydrates, which are found in great numbers in alcohol (Javors and Johnson 2003).
In some embodiments the disclosed device focuses on detecting markers associated with alcohol abuse from menstrual blood or cervicovaginal fluid.
Me mam was a severe alcoholic. I used to get beat up daily. The school didn’t do anything until I was 12-year old, after me nanna died. And basically, I got put with the person who was actually raping me. So I was there for 3 months and the trauma of that, I just couldn’t cope with. So I rebelled at school, and that’s when I got put into […] children’s home. Things started to calm down a little bit there, but I just wanted to be – it sounds stupid – but I wanted to be where my safety net was, where my mam was (Rosie).
I was beaten as a child by my father. My mother beat my sister. Never ever hit me. Sides get picked, you get her I get her. And I thought it was how someone showed that they loved you, you know? … I had my nose broken. First my dad. And then boyfriends. There was a competition going on. It becomes a way of life I guess (Tracy).