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Glycyrrhiza

Glycyrrhiza, a genus of perennial leguminous herbs, is a valuable medicinal plant widely used in traditional and modern medicine.
Its root, commonly known as licorice, contains numerous bioactive compounds with diverse pharmacological properties.
Glycyrrhiza has been extensively studied for its anti-inflammatory, antioxidant, antimicrobial, and neuroprotective effects, among others.
Researchers utilize a variety of experimental protocols to investigate the therapeutic potential of this versatile plant.
PubCompare.ai's AI-driven protocol comparison can optimize your Glycyrrhiza research by helping you easily locate the most reproducible and effective methods from the literature, preprints, and patents.
Experince the power of AI-driven science with PubCompare.ai to enhance the efficacy and impact of your Glycyrrhiza studies.

Most cited protocols related to «Glycyrrhiza»

1
Taiwanese Primary Aldosteronism Evaluation
Cited 6 times
The present study was based on the Taiwan Primary Aldosteronism Investigation (TAIPAI) database. From June 2006 to March 2008, the random urine and 24-h urine samples of the referred patients were routinely analyzed. A total of 222 hypertensive patients were referred to our hypertension clinic for the confirmation of PA after an initial evaluation. The database was constructed for quality assurance in 1 medical center (National Taiwan University Hospital, Taipei, Taiwan) and its 3 affiliated hospitals in different cities (National Taiwan University Hospital Yun-Lin branch, Yun-Lin, southern Taiwan; Tzi-Chi Hospital, Taipei; and Tao-Yuan General Hospital, Tao-Yuan, central Taiwan). All patients hospitalized with the intention to confirm PA diagnosis and who received salt loading test were recruited. Patients were excluded because of loss to follow-up (n = 13), incomplete urinary collection (n = 18), chronic kidney disease with a decreased estimated glomerular filtration rate ([GFR] <60 mL/[min·1.73 m2]; n = 11), heart failure, New York Heart Association (NYHA) class II or higher (n = 5), hyperthyroidism (n = 2), and malignancy with metastasis (n = 6) (Fig. 1). All antihypertensive medications were discontinued for at least 21 days before the study. Diltiazem and/or doxazosin were administered for control of marked high blood pressure when required [1] (link). Medications that might interfere with the renin-aldosterone axis, including steroids, sex hormones, licorice, or non-steroidal anti-inflammatory drugs, were also withheld.
Wu C.H., Yang Y.W., Hu Y.H., Tsai Y.C., Kuo K.L., Lin Y.H., Hung S.C., Wu V.C, & Wu K.D. (2013). Comparison of 24-h Urinary Aldosterone Level and Random Urinary Aldosterone-to-Creatinine Ratio in the Diagnosis of Primary Aldosteronism. PLoS ONE, 8(6), e67417.
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Publication 2013
Aldosterone Anti-Inflammatory Agents, Non-Steroidal Antihypertensive Agents Chronic Kidney Diseases Congestive Heart Failure Conn Syndrome Diagnosis Diltiazem Doxazosin Epistropheus Glycyrrhiza Gonadal Steroid Hormones Heart High Blood Pressures Hyperthyroidism Neoplasm Metastasis Patients Pharmaceutical Preparations Renin Sodium Chloride, Dietary Steroids Urine Urine Specimen Collection
2
Compounds Identification of XYP
Cited 4 times
To collect the compounds of XYP, we used the TCM Database@Taiwan [24 (link)] (http://tcm.cmu.edu.tw/zh-tw/, updated in March 2014), which is the most comprehensive TCM database in the world, and the Traditional Chinese Medicine Systems Pharmacology Database [25 (link)] (TcmSP™, http://lsp.nwsuaf.edu.cn, updated on May 31, 2014), a unique system pharmacology platform designed for Chinese herbal medicines. Nine hundred and fifty-eight compounds were found, 348 in Radix Bupleuri, 175 in Angelicae Sinensis Radix, 92 in Paeoniae Radix Alba, 52 in Poria Cocos (Schw.) Wolf., 63 in Atractylodes Macrocephala Koidz., and 318 in Licorice. According to research [26 , 27 ], we filtered these compounds and get 11 representative compounds (active compounds); they are saikosaponin, longispinogenin, ferulic acid, ligustilide, total glucosides of peony (TGP), atractylol, atractylenolide I, atractylenolide III, pachyman, pachymic acid, and glycyrrhizin. The details are described in Table S1 (see Supplementary Material available online at http://dx.doi.org/10.1155/2016/2960372).
Liu H., Zeng L., Yang K, & Zhang G. (2016). A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility. Evidence-based Complementary and Alternative Medicine : eCAM, 2016, 2960372.
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Publication 2016
atractylenolide I atractylenolide III Atractylodes Bupleurum root Chinese ferulic acid Glucosides Glycyrrhiza Glycyrrhizic Acid ligustilide Medicinal Herbs pachyman pachymic acid paeoniae radix alba Peony Plant Roots Wolfiporia extensa Wolves
3
Preparation of Retort-Pouched Samgyetang
Cited 3 times
The broth for Samgyetang was prepared using 180 g of Astragalus membranaceus root, 300 g of Mulberry branch, 276 g of Kalopanax septemlobus branch, 60 g of licorice, 324 g of Siberian ginseng, and 210 g of salt per 36 L of water, followed by boiling for approximately 1 hour. The solids in the broth were removed, and the broth was filtered using a stainless mesh filter (8 mm). The final salt concentration was adjusted to 0.6% using a salinity meter (PAL-03S, Atago Co., Ltd., Tokyo, Japan) and by adding drinking water.
To prepare the stuffing, glutinous rice was soaked for 1 h and rinsed prior to use. Garlic, ginseng, and dried jujube were rinsed with cold water. Approximately 35 g of glutinous rice, 8 g of garlic, 5 g of jujube and 7 g of ginseng were placed in rice paper, which was soaked with warm water, and wrapped. The wrapped rice, breast and thigh meat were then stuffed into a retort pouch (length 19 cm [length]×25 cm [height], polyethylene terephthalate = 16 μm, aluminum = 9 μm, nylon = 15 μm, polypropylene =100 μm) gifted from Sunbong Food (Incheon, Korea) and were filled with broth until the weight reached 1,000±0.05 g. The pouches were then sealed (WB-1150VP; Woobin Tech Co., Ltd., Incheon, Korea). Two extra pouches were used to measure the F0 value during the retorting process. The retort process was performed using a steam-type retort sterilization chamber (Steri-ace, Kyungshan Co., Ltd., Gyeongsan, Korea). The heating process was started at 65°C, and the temperature was raised to 121°C for the first sterilization (pressure = 1.5 kgf/cm2; holding time = 3 min). Next, the temperature was raised again to 122°C for 10 s for the second sterilization (pressure = 1.7 kgf/cm2; holding time = 95 min). The cooling process was held at 1.7 kgf/cm2 for 20 min. Retort-pouched Samgyetang was stored in a refrigerator (5°C±0.5°C) prior to analysis (within 3 days). For analysis, 10 pouches of retorted Samgyetang from each treatment group were used for meat quality analysis, while the other 28 pouches from each treatment group were used for sensory evaluation.
Jeong H.S., Utama D.T., Kim J., Barido F.H, & Lee S.K. (2019). Quality comparison of retorted Samgyetang made from white semi-broilers, commercial broilers, Korean native chickens, and old laying hens. Asian-Australasian Journal of Animal Sciences, 33(1), 139-147.
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Publication 2019
Aluminum ARID1A protein, human Breast Cold Temperature Food Garlic Ginseng Glycyrrhiza Huang Qi Jujube Kalopanax Meat Morus Nylons Oryza sativa Polyethylene Terephthalates Polypropylenes Pressure Salinity Siberian Ginsengs Silene Sodium Chloride Steam Sterilization Thigh
4
Glycyrrhizic Acid Protects Liver from Thioacetamide-Induced Injury
Cited 3 times
The Wistar rats were divided into five groups with 10 individuals for each group randomly (Table 1). Animals in normal control (NC) group received distilled water for 6 days and 0.5% CMC-Na for the last 3 days. Rats in TP model group (TP), GA low-dose group (GAL+TP), and GA high-dose group (GAH+TP) received distilled water, GA (50 mg/kg, p.o., dissolved in distilled water), or GA (100 mg/kg, p.o., dissolved in distilled water) for consecutive 6 days, respectively, and liver injury was induced by TP (2.4 mg/kg, p.o., suspended in 0.5% CMC-Na) for the last 3 days. Animals in the above three groups received TP 6 hours after distilled water or GA treatment on the last 3 days. The doses of GA range within 5~75 mg/kg for rats in the existing hepatic protection reports [11 (link), 20 (link), 23 (link), 24 (link)], so we choose a most commonly used dose (50 mg/kg, equivalent to Licorice 18.52 g/d for human) as the low dose. In order to explore whether a high-dose GA that exceeded the common level still has a hepatic protective effect, we choose a dose (100 mg/kg, equivalent to Licorice 37.04 g/d for human) as the high dose. In addition, to observe whether high dose of GA influences hepatic function by itself, we set a GA high-dose control (GAH) group, in which rats received GA (100 mg/kg) only.
Twenty-four hours after the last dosing, blood samples were collected using capillaries from rats' orbital venous plexus. Then the animals were sacrificed and livers were removed immediately. Serum was prepared by centrifugation at 4°C, 3500 rpm for 15 min as routine method. The supernatants of 10% liver homogenate were obtained by centrifugation at 4°C, 12000 rpm for 10 min, and kept at −80°C until analysis.
Yang G., Wang L., Yu X., Huang Y., Qu C., Zhang Z., Luo D., Lin J., Zhou L., Su Z., Zhang X, & Chen H. (2017). Protective Effect of 18β-Glycyrrhetinic Acid against Triptolide-Induced Hepatotoxicity in Rats. Evidence-based Complementary and Alternative Medicine : eCAM, 2017, 3470320.
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Publication 2017
Animals BLOOD Capillaries Centrifugation Glycyrrhiza Homo sapiens Injuries Liver Rats, Wistar Rattus norvegicus Serum Veins
5
Pharmacological Profiling of QSG Herbal Decoction
Cited 2 times
QSG, also published under the name of Yixin Jiedu Decoction, Qishenkeli and Qishenyiqi in the past, consists of 6 species of medicinal herbs: Hedysarum Multijugum Maxim (Huangqi), Radix Salviae (Danshen), Lonicerae Japonicae Flos (Jinyinhua), Figwort Root (Xuanshen), Aconiti Lateralis Radix Praeparata (Fuzi), and licorice (Gancao). The compounds of the 6 herbs identified in QSG were obtained from the TCM systems pharmacology database and analysis platform (TCMSP, http://ibts.hkbu.edu.hk/LSP/tcmsp.php), the TCM Database@Taiwan (http://tcm.cmu.edu.tw), the TCM information database (TCMID, http://bidd.nus.edu.sg/group/TCMsite/), and the Bioinformatics analysis tool for molecular mechanism of TCM (Batman, http://bionet.ncpsb.org/batman-tcm/). They contain comprehensive information of all herb ingredients for drug screening and evaluation [20 (link)]. Oral bioavailability and drug-likeness were selected for identification of bioactive ingredients. The common screening criteria are oral bioavailability ≥30% and drug-likeness ≥0.18 [21 (link)]. Additionally, the names of compounds were standardized according to PubChem CIDs (https://pubchem.ncbi.nlm.nih.gov/).
Liu J., Li Y., Zhang Y., Huo M., Sun X., Xu Z., Tan N., Du K., Wang Y., Zhang J, & Wang W. (2019). A Network Pharmacology Approach to Explore the Mechanisms of Qishen Granules in Heart Failure. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 25, 7735-7745.
Publication 2019
Aconite dan-shen root extract fuzi drug herbal Glycyrrhiza glycyrrhizae radix et rhizoma Huang Qi lonicerae flos Medicinal Herbs Pharmaceutical Preparations Plant Roots qishen yiqi

Most recents protocols related to «Glycyrrhiza»

1
Multi-Herb Granule Treatment for Medicinal Use
TSUMURA Ninjin’yoeito Extract Granules for Ethical Use (TJ-108; Tsumura & Co., Tokyo, Japan) is composed of twelve crude drugs (Rehmannia Root, Japanese Angelica Root, Atractylodes Rhizome, Poria Sclerotium, Ginseng, Cinnamon Bark, Polygala Root, Peony Root, Citrus Unshiu Peel, Astragalus Root, Glycyrrhiza, and Schisandra Fruit), and was administered three times daily (3 g each time, 9 g/day) during the 24-week treatment period. The dose of NYT could be reduced to 6 g/day administered twice daily, depending on the subject’s age, body weight, and response to the treatment (e.g., adverse events). For the assessment of adverse events, we used the package insert of NYT and medical opinion to judge whether there was a causal relationship between the treatment and the adverse reaction. Approval was received from the CRB.
Okahara K., Ohsawa M., Haruta-Tsukamoto A., Miyoshi R., Funahashi H., Fukutani Y., Makita S., Matsuo H, & Ishida Y. (2023). Frailty Improvement by Multicomponent Drug, Ninjin’Yoeito, in Mild Cognitive Impairment and Mild Alzheimer’s Disease Patients: An Open-Label Exploratory Study (FRAMINGO). Journal of Alzheimer's Disease Reports, 7(1), 107-117.
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Publication 2023
Angelica Atractylodes Body Weight Citrus Cortex, Cerebral Cytoplasmic Granules Fruit Ginseng Glycyrrhiza Huang Qi Japanese peony root extract Pharmaceutical Preparations Plant Roots Polygala Poria Rhizome Schisandra sheng-di-huang TJ-108
2
Noscough® Syrup for Cough Symptoms
The patients in the Noscough® group received Noscough® syrup (Faran Shimi, Iran, each 5 mL contain 7 mg noscapine and 5 mg licorice extract), 20 mL every 6 h for 5 days. The control group received diphenhydramine (Pursina, Iran, each 5 mL contain 12.5 mg diphenhydramine) 7 mL every 8 h. No other medications were received. Patients in both groups received cetirizine 10 mg once daily for the relief of coryzal symptoms. Patients were allowed to leave the study at any time. Their demographic characteristics, underlying diseases, and medication histories were recorded at baseline.
Barati S., Feizabadi F., Khalaj H., Sheikhzadeh H., Jamaati H.R., Farajidavar H, & Dastan F. (2023). Evaluation of noscapine-licorice combination effects on cough relieving in COVID-19 outpatients: A randomized controlled trial. Frontiers in Pharmacology, 14, 1102940.
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Publication 2023
Cetirizine Common Cold Diphenhydramine Glycyrrhiza Noscapine Patients Pharmaceutical Preparations
3
Herbal Decoction for Bioactive Compound Extraction
Eight raw herbs of BSHS were provided from the pharmacy department of the Wuqing Hospital of Traditional Chinese Medicine affiliated with Tianjin University of Traditional Chinese Medicine(Tianjin, China) (Supplementary Figure 1). Lysimachiae Herba, Lygodii Spora, Plantaginis Semen, Clerodendranthus Spicatus, Cibotii Rhizoma, Dipsaci Radix, Malva verticillata seed, and Licorice were mixed in proportions of 3:1.5:1.5:3:1.5:1.5:1.5:1(w/w) respectively and then soaked in 12 times the volume of distilled water (v/m) for 1 h, decocted twice, at 1.5 h per decoction. After concentrating the decoction to 1 g/mL, it was stored at -20°C until used.
Liu H., Cao M., Jin Y., Jia B., Wang L., Dong M., Han L., Abankwah J., Liu J., Zhou T., Chen B., Wang Y, & Bian Y. (2023). Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of Bushen Huashi decoction against kidney stones. Frontiers in Endocrinology, 14, 1031895.
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Publication 2023
borocaptate sodium Glycyrrhiza Malva Plant Roots Rhizome
4
Pharmacological Analysis of BSHS Herbs
Cited 1 time
We used the TCMSP database (http://www.tcmspw.com/tcmsp.php) to search for BSHS constituent medicines (Lysimachiae Herba, Lygodii Spora, Plantaginis Semen, Dipsaci Radix, and Licorice) and their chemical and pharmacological data. The remaining herbs, such as Clerodendranthus spicatus, Cibotii Rhizoma, and Malva verticillata seed were not retrieved from the database; however, their active compounds were retrieved by reviewing the literature. As parameters for screening the compounds collected, oral bioavailability (OB) and drug-like quality (DL) were selected. The OB represents the percentage of unchanged drug that reaches the systemic circulation after oral administration. DL indexes can be used to optimize pharmacokinetic and pharmaceutical properties, such as solubility and chemical stability (17 (link)). Here, we set OB ≥ 30 and DL ≥ 0.18 as criteria to screen for biologically active compounds. TCMSP was further used to screen the targets of the active ingredients of BSHS, and Uniprot was used to correct and deduplicate the drug targets. (https://www.uniprot.org/).
Liu H., Cao M., Jin Y., Jia B., Wang L., Dong M., Han L., Abankwah J., Liu J., Zhou T., Chen B., Wang Y, & Bian Y. (2023). Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of Bushen Huashi decoction against kidney stones. Frontiers in Endocrinology, 14, 1031895.
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Publication 2023
Administration, Oral borocaptate sodium Drug Delivery Systems Glycyrrhiza Malva Pharmaceutical Preparations Plant Roots Rhizome
5
Standardized Preparation and Composition of HZOL
HZOL was purchased from the Taiji Group Chongqing Fuling Pharmaceutical Co., Ltd. Production of HZOL following the Chinese Pharmacopeia 2015 (Approved number, Z50020409; Lot number, 20071956). Quality of HZOL was able to ascertain both stability and controllability. Introduction of HZOL was follows: firstly, prescription of HZOL consists of ten herbs including Atractylodis Rhizoma 80 g, Magnoliae Officinalis Cortex 80 g, Poria 120 g, Pinelliae Rhizoma 80 g, Citri Reticulatae Pericarpium 80 g, Angelicae Dahuricae Radix 120 g, Arecae Pericarpium 120 g, Licorice extract 10 g, Patchouli oil 0.8 mL, and volatile oil in Perillae Folium 0.4 mL. Secondly, HZOL was standardised prepared following the method of the criteria of the Chinese Pharmacopeia 2015 as previous study described [10 (link)]. Thirdly, content determination of HZOL was controlled with magnolol, honokiol, and hesperidin. In a nutshell, per milliliter of HZOL contained magnolol and honokiol no less than 0.30 mg and hesperidin no less than 0.10 mg.
Tang R., Zhang J., Zhang R., Li X., Lv R., Nan H., Liu J., Zhao Z., He W, & Wang L. (2023). Huoxiang Zhengqi Oral Liquid Attenuates LPS-Induced Acute Lung Injury by Modulating Short-Chain Fatty Acid Levels and TLR4/NF-κB p65 Pathway. BioMed Research International, 2023, 6183551.
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Publication 2023
Areca Chinese Cortex, Cerebral Glycyrrhiza Hesperidin honokiol magnolol Oils, Volatile Pharmaceutical Preparations Plant Leaves Plant Roots Pogostemon cablin Poria Rhizome

Top products related to «Glycyrrhiza»

1
Acetonitrile by Merck Group
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3
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Dneasy powersoil kit by Qiagen
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More about "Glycyrrhiza"

Glycyrrhiza, a genus of perennial leguminous herbs, is a valuable medicinal plant widely used in traditional and modern medicine.
Its root, commonly known as licorice, contains numerous bioactive compounds with diverse pharmacological properties.
Glycyrrhiza has been extensively studied for its anti-inflammatory, antioxidant, antimicrobial, and neuroprotective effects, among others.
Researchers utilize a variety of experimental protocols to investigate the therapeutic potential of this versatile plant.
Acetonitrile and formic acid are commonly used solvents and reagents in the analysis of Glycyrrhiza and its active compounds, such as glabridin.
DMEM (Dulbecco's Modified Eagle Medium) is a widely used cell culture medium for in vitro studies involving Glycyrrhiza extracts or purified compounds.
The DNeasy PowerSoil Kit is a tool used for the extraction and purification of DNA from soil samples, which can be important for studying the microbial diversity associated with Glycyrrhiza plants.
CytoNCA is a software tool that can be employed for the analysis of cytotoxicity data, which is relevant for evaluating the safety and efficacy of Glycyrrhiza-derived compounds.
The 1100 HPLC (High-Performance Liquid Chromatography) system is a common analytical instrument used for the separation, identification, and quantification of bioactive compounds in Glycyrrhiza extracts.
Stata 15 is a statistical software package that can be utilized for the analysis of data generated from Glycyrrhiza research, including the assessment of pharmacological activities and dose-response relationships.
Gallic acid is a phenolic compound that has been identified in Glycyrrhiza and has been studied for its antioxidant and other therapeutic properties.
The Ultrospec 2100 pro is a spectrophotometer that can be used for the quantification of various phytochemicals and bioactive compounds in Glycyrrhiza samples.
PubCompare.ai's AI-driven protocol comparison can optimise your Glycyrrhiza research by helping you easily locate the most reproducible and effective methods from the literature, preprints, and patents.
Experince the power of AI-driven science with PubCompare.ai to enhance the efficacy and impact of your Glycyrrhiza studies.