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Ex-Smokers

Ex-Smokers refers to individuals who have previously smoked but have since quit the habit.
These individuals face unique challenges in maintaining their abstinence and preventing relapse.
PubCompare.ai's AI-driven platform can assist ex-smokers in optimizeing their research protocols, ensuring reproducibility and accuracy.
The platform enables users to locate relevant protocols from literature, pre-prints, and patents, and leverages AI-driven comparisons to identify the best protocols and products.
This takes the guesswork out of research, empowering ex-smokers to make informed decisions and achieve their health goals.
With PubCompare.ai's powerful tools, ex-smokers can navigate the complexities of their journey with confidence and ease.

Most cited protocols related to «Ex-Smokers»

Statistical analyses were conducted with SPSS software (version 23.0; SPSS, Chicago, IL, USA). No formal sample size estimation was made because there has not been any published nationwide data on COVID-19. Nonetheless, our sample size was deemed sufficient to power the statistical analysis given its representativeness of the national patient population. Continuous variables were presented as mean±sd or median (interquartile ranges (IQR)) as appropriate, and the categorical variables were presented as counts and percentages. Since no random sampling was conducted, all statistical analyses were descriptive and no p-values were presented for the statistical comparisons except for the Cox proportional hazards regression model. Cox proportional hazards regression models were applied to determine the potential risk factors associated with the composite end-points, with the hazard ratio and 95% confidence interval being reported. Our findings indicated that the statistical assumption of proportional hazards analysis was not violated. Moreover, a Cox regression model was considered more appropriate than a logistic regression model because it took into account the potential impact of the various durations of follow-up from individual patients. Age and smoking status were adjusted for in the proportional hazards regression model because they had been recognised as the risk factors of comorbidities even in the general population. Smoking status was stratified as current smoker, ex-smoker and never-smoker in the regression models.
Publication 2020
COVID 19 Ex-Smokers Patient Representatives Patients
Patients were randomised if they met the following main inclusion criteria: outpatients aged ≥40 years with a history of moderate to very severe COPD (GOLD stage 2–4) [23 ]; post-bronchodilator FEV1 <80% of predicted normal; post-bronchodilator FEV1/forced vital capacity (FVC) <70%; current or ex-smokers with a smoking history of >10 pack–years.
Patients with a significant disease other than COPD were excluded from the trials. Other exclusion criteria included: clinically relevant abnormal baseline laboratory parameters or a history of asthma; myocardial infarction within 1 year of screening; unstable or life-threatening cardiac arrhythmia; known active tuberculosis; clinically evident bronchiectasis; cystic fibrosis or life-threatening pulmonary obstruction; hospitalised for heart failure within the past year; diagnosed thyrotoxicosis or paroxysmal tachycardia; previous thoracotomy with pulmonary resection; regular use of daytime oxygen if patients were unable to abstain during clinic visits; or currently enrolled in a pulmonary rehabilitation programme (or completed in the 6 weeks before screening).
Patients with moderate or severe renal impairment (creatinine clearance ≤50 mL·min−1) were not excluded from the study but were closely monitored by the investigator.
Both studies were performed in accordance with the Declaration of Helsinki, International Conference on Harmonisation Harmonised Tripartite Guideline for Good Clinical Practice and local regulations. The protocols were approved by the authorities and the ethics committees of the respective institutions, and signed informed consent was obtained from all patients.
Publication 2015
Airway Obstruction Asthma Bronchiectasis Bronchodilator Agents Cardiac Conduction System Disease Chronic Obstructive Airway Disease Clinic Visits Conferences Creatinine Cystic Fibrosis Ex-Smokers Forced Vital Capacity Gold Heart Failure Institutional Ethics Committees Lung Myocardial Infarction Outpatients Oxygen Patients Rehabilitation Renal Insufficiency Tachycardia, Paroxysmal Thoracotomy Thyrotoxicosis Tuberculosis
Power calculation was based on precision of effect estimates in COPD subgroups for rate of decline in FEV1 over 3 years (confidence interval width of at most 15 mL/year in rate of FEV1 decline). The sizes of the control groups were based on both the ability to detect a difference of at least 16.5 mL/year rate of decline in FEV1 between COPD patients and controls, and to detect a 50% increase in exposure (required 5-7 COPD patients per control) for any diagnostic test. Based upon these calculations, we studied 2164 patients with COPD (GOLD stage 2-4), 337 smoking controls and 245 non-smoking controls (Figure 1). Inclusion criteria were as follows [4 (link)]. COPD patients: (1) Male/female subjects aged 40-75 years; (2) Baseline post-bronchodilator FEV1 < 80% of the reference value and FEV1/FVC ≤0.7; and, (3) Current or ex-smokers with a smoking history of ≥10 pack-years. Smoker controls: (1) Male/female subjects aged 40-75 years, who are free from significant disease as determined by history, physical examination and screening investigations; (2) Baseline post-bronchodilator FEV1 > 85% of the reference value and FEV1/FVC > 0.7; and, (3) Current or ex-smokers with a smoking history ≥10 pack-years. Non smoking controls: (1) Male/female subjects aged 40-75 years, who are free from significant disease as determined by history, physical examination and screening investigations; (2) Baseline post-bronchodilator FEV1 > 85% of the reference value and FEV1/FVC > 0.7; and, (3) Smoking history of <1 pack-year. Besides, all participants: (4) signed and dated their written informed consent prior to participation (which had been approved by the Ethics Committees of all participating institutions); and, (5) had to have the ability to comply with the requirements of the protocol and be available for study visits over 3 years. Key exclusion criteria were the presence of a respiratory disorder other than COPD, other significant inflammatory diseases or a reported COPD exacerbation within 4 weeks of enrolment [4 (link)]. COPD patients were recruited from the outpatient clinics of the participating centres (Figure 1). Smoker and non-smoker controls were recruited through site databases and other methods (advertisements in local newspapers and television/radio stations) where appropriate. Figure 2 presents the variability of age (panel A), gender (panel B), smoking status (panel C) and FEV1 (panel D) in the three groups of individuals recruited into ECLIPSE (COPD patients, smokers and non-smokers with normal lung function) by each of the 46 participating centres.
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Publication 2010
Bronchodilator Agents Chronic Obstructive Airway Disease Ex-Smokers Gender Gold Inflammation Institutional Ethics Committees Males Non-Smokers Patients Physical Examination Respiration Disorders Respiratory Physiology Tests, Diagnostic Woman
Data analysis was performed using SPSS version 9.0 (SPSS Inc, USA). Data are expressed as medians (range) unless stated otherwise. Internal consistency of the CCQ was evaluated by determining the Cronbach's α coefficient (for the three domains and the total questionnaire). Non parametrical testing (Mann-Whitney U test) was used to determine the discriminant validity of the CCQ to differentiate among healthy (ex) smokers, patients with COPD (stages 0 to III). Spearman's rank correlations were used to examine convergent (HRQoL) and divergent (lung function) validity. Test-retest reliability analysis was done by calculating the Intraclass Correlation Coefficient (ICC). Responsiveness was tested using the Wilcoxon U test. A p value < 0.05 was considered as statistically significant. A priori assumptions of the relations between the CCQ and convergent and divergent measures were made by the research team in advance of the validation study
Publication 2003
Chronic Obstructive Airway Disease Ex-Smokers Patients Respiratory Physiology
All subjects were recruited from the Respiratory Medicine Unit of the ‘Fondazione Salvatore Maugeri’ (Veruno, Italy), the Section of Respiratory Diseases of the University Hospital of Ferrara, Italy and the Section of Respiratory Diseases of the University Hospital of Katowice, Poland for immunohistochemistry and ELISA experiments. The severity of the airflow limitation, as determined by spirometry, was graded using Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria.19 (link) All former smokers had stopped smoking for at least 1 year. COPD and chronic bronchitis were defined, according to international guidelines: COPD, presence of a post-bronchodilator forced expiratory volume in 1s (FEV1)/forced vital capacity ratio <70%; chronic bronchitis, presence of cough and sputum production for at least 3 months in each of two consecutive years (http://www.goldcopd.com). All patients with COPD were stable. The study conformed to the Declaration of Helsinki. We obtained and studied bronchial biopsies from 55 subjects: 32 had a diagnosis of COPD in a stable clinical state,20 (link) 12 were current or ex-smokers with normal lung function, and 11 were non-smokers with normal lung function (table 1). The smoking history was similar in the three smoker groups: mild/moderate and severe/very severe COPD, and healthy smokers with normal lung function. Clinical details of the patients in whom BAL was collected are summarised in table 2. The results provided are the data from 26 patients with COPD and 18 control smokers with normal lung function. Due to the necessity to concentrate the BAL supernatants the results provided for each ELISA are the data from 15 patients with COPD and 14 control smokers with normal lung function which are not the same patients for all mediators measured.
A detailed description of subjects, lung function tests, fibreoptic bronchoscopy and processing of bronchial biopsies and BAL, immunohistochemistry, scoring system for immunohistochemistry, double staining and confocal microscopy, ELISA tests performed on the BAL fluid and ‘in vitro’ experiments performed on normal human bronchial epithelial (NHBE) cells and details of statistical analysis are provided in the online supplementary data repository.
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Publication 2014
Biopsy Bronchi Bronchitis, Chronic Bronchodilator Agents Bronchoscopy Chronic Obstructive Airway Disease Cough Diagnosis Enzyme-Linked Immunosorbent Assay Epithelial Cells Ex-Smokers Gold Homo sapiens Immunohistochemistry Microscopy, Confocal Non-Smokers Patients Respiration Disorders Respiratory Physiology Spirometry Sputum Tests, Pulmonary Function Vital Capacity Volumes, Forced Expiratory

Most recents protocols related to «Ex-Smokers»

This section elicited data regarding socio-demographic characteristics, academia-related factors, and lifestyle factors. Data concerning socio-demographic characteristics included age, gender, family's monthly income, marital status, father's education, parents' marital status, birth order, body mass index (BMI), and smoking. The academia-related factors included year of study and self-reported Grade Point Average (GPA). The years of study were grouped into two academic levels (Junior: second and third year; Senior: fourth to sixth year). Lifestyle factors included smoking status, physical exercise, tea consumption, coffee consumption, and energy drink consumption. Smoking status was defined as follows: current smoker is any person who smoked regularly in the past month at the time of responding; ex-smoker, who quit smoking at least 1 month prior to the study; and nonsmoker as someone who has never smoked.
Publication 2023
Coffee Energy Drinks Ex-Smokers Gender Index, Body Mass Non-Smokers Parent
Age, sex, co-morbidities including hypertension, diabetes, dyslipidemia, heart failure, prior stroke, prior myocardial infarction, peripheral artery disease, chronic kidney disease, chronic obstructive pulmonary disease (COPD), and cancer, CHA2DS2-VASc score, Charlson Comorbidity Index (CCI), and concomitant use of antiplatelet agents were evaluated as covariates. The operational definitions of co-morbidities were based on diagnostic codes, drug dispensing records, and inpatient/outpatient hospital visits within 3 years prior to the index date. Complete definitions of each covariate are presented in Supplementary Tables S1 and S2 (5 (link), 15 (link), 16 (link)).
Among the total study population, 67.4% of patients had the data from the baseline national health examination, and 23.4% had the data from both baseline and at least one follow-up national health examination. From the health examination data, body weight, body mass index (kg/m2), serum creatinine (mg/dL) and eGFR (mL/min/1.73 m2) were collected. eGFR was calculated by a creatinine-based equation used from Modification of Diet in Renal Disease. In addition, smoking status (never smoker, ex-smoker, or current smoker), alcohol consumption (heavy drinker, ≥ 30 g/day), and physical activity were also evaluated from the self-reported questionnaires of health examination. Regular exercise was defined as performing moderate-intensity exercise ≥ 5 times per week or vigorous-intensity exercise ≥ 3 times per week (17 (link)).
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Publication 2023
Alcoholic Intoxication Antiplatelet Agents Body Weight Cerebrovascular Accident Chronic Kidney Diseases Chronic Obstructive Airway Disease Creatinine Diabetes Mellitus Diagnosis Dietary Modification Dyslipidemias EGFR protein, human Ex-Smokers Heart Failure High Blood Pressures Index, Body Mass Inpatient Kidney Diseases Malignant Neoplasms Myocardial Infarction Outpatients Patients Peripheral Arterial Diseases Pharmaceutical Preparations Self-Examination Serum
For this cross-sectional study, a self-administered online questionnaire-based survey was conducted, between April and October 2019, among a group of pulmonologists who were members of the Turkish Thoracic Society. The TTS is an organization for healthcare professionals, akin to various pulmonology associations worldwide, and most of its members are pulmonologists.
The findings of this study were produced by reanalyzing part of the data obtained from an overarching TTS scientific research project entitled ‘Knowledge, attitudes, and behavior of the pulmonologist members of TTS towards tobacco and new tobacco products’. The study protocol was approved by the TTS Scientific Project Committee. After a pre-test, the TTS secretariat emailed a link to a self-administered online questionnaire on Survey Monkey (surveymonkey.com) containing a written informed consent form to 2941 pulmonologist members of TTS. Weekly reminders were made to boost the number of participants. As we could not confirm if the e-mails were received and read by all these members, we estimated the response rate as the number of total completed surveys divided by the number of registered TTS pulmonologists. The questionnaire asked about gender, age, medical school graduation date, academic position, smoking status, the existence and the source of training on smoking cessation care (SCC), and about the presence of providing outpatient-based SCC. Outpatient-based SCC includes providing both counselling and smoking cessation medication in a dedicated smoking cessation outpatient clinic that is offered as an outpatient health service in Turkey. The categorical variables were dichotomized, e.g. academic position was dichotomized as having or not having any academic employment.
The WHO classification system was used to determine smoking status16 . Individuals who had smoked for at least six months in their lives and who were smoking continually at the time of the survey were categorized as ‘current smokers’. Ex-smokers (smoked for at least 6 months during their lifetime but not within the 6 months prior to the survey), recent quitters (smoked for at least 6 months during their lifetime but not within the 6 months prior to the survey), and never smokers (never smoked or had smoked for less than 6 months or fewer than 100 cigarettes during the survey) were classified as ‘non-current smokers’.
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Publication 2023
Ex-Smokers Gender Health Care Professionals Health Services, Outpatient Monkeys Non-Smokers Outpatients Pharmaceutical Preparations Pulmonologists Tobacco Products
An index date was considered, which is deemed for each case as the day of appearance of dark vomiting or in coffee grounds, melena, and/or hematemesis (signs and symptoms of UGIB) and for controls the index date was defined as the date of the interview (13 (link)). To assess an association between the use of NSAIDs and LDA with the risk of UGIB, a 7-day etiologic window dated from the index date was considered, in line with other published studies (12 (link), 14 (link)).
For CYP2C9 analysis, NSAIDs use was grouped into NSAIDs metabolized at least 50% by CYP2C9 (piroxicam, celecoxib, naproxen, aceclofenac, indomethacin, diclofenac, and ibuprofen) and into NSAIDs metabolized less than 50% by CYP2C9 (other NSAIDs) (12 (link)). It is known that NSAIDs, as they are substrates of CYP2C9, are not metabolized at the same proportion of this enzyme and to perform an analysis considering the proportion of each NSAIDs metabolized by CYP2C9 increases the sample size power (7 (link)). LDA use was deemed the continuous use of aspirin at doses below 300 mg per day in the indication of prevention of primary and secondary cardiovascular events (15 (link)).
To perform an analysis of dose-effect, two researchers calculated the defined daily dose (DDD) by the World Health Organization (WHO) for NSAIDs for all participants. DDD was defined as the average maintenance dose per day of a drug used for its main indication in adults in the 7-day etiologic window preceding the data index. The dose-response effect was assessed using three categories: NSAIDs non-users (NSAIDs DDD = 0), NSAIDs users of 0.50 DDD or less (>0 NSAIDs DDD ≤0.50), and NSAIDs users of over 0.50 DDD (NSAIDs DDD >0.50) based on the proposal by Figueiras et al. (12 (link)). This approach considered each type of NSAIDs and the recommended DDD, enabling different NSAIDs to be compared with one another (7 (link)).
Regarding lifestyle, the mean daily consumption of tobacco, alcohol, and coffee over the 2 months preceding the index was calculated. Smoking habit was stratified according to the number of cigarettes consumed per day: non-smokers and ex-smokers (zero cigarette); 1 to 15 cigarettes/day; and >15 cigarettes/day. Alcohol intake was stratified in abstainers (0 g), >0 to ≤30 g of alcohol/day, and >30 g of alcohol. Coffee intake was stratified into none consumed (0 mL), >0 mL ≤ 100, >100 > mL ≤ 300, and >300 mL.
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Publication 2023
aceclofenac Adult Anti-Inflammatory Agents, Non-Steroidal Aspirin Cardiovascular System Celecoxib Coffee Diclofenac Enzymes Ethanol Ex-Smokers Hematemesis Ibuprofen Indomethacin Melena Naproxen Non-Smokers Pharmaceutical Preparations Piroxicam Primary Prevention
As previously mentioned21 (link), the researchers used questionnaires, physical examinations, and blood tests to obtain baseline data from the participants. Subjects were categorized depending on average weekly ethanol and type of alcohol intake. Alcohol intake of less than 40 g per week is defined as no or minimal alcohol consumption23 (link). Weekly alcohol intake of 40 g to 140 g is defined as light alcohol consumption23 (link). Alcohol intake of 140 g to 280 g per week is defined as moderate alcohol consumption23 (link). Weekly alcohol intake greater than 280 g is defined as heavy alcohol consumption23 (link). Participants were divided into non-smokers, ex-smokers, and current smokers based on their smoking status at baseline. Non-smokers were defifined as participants who never smoked cigarettes, ex-smokers as participants who had smoked in the past but who quit smoking until the baseline visit, and current-smokers as participants who smoked at the baseline visit21 (link).
Regular participation in sports > 1x/week is defined as regular exercise. 24 (link). Body mass index is calculated as the number of kilograms of body weight divided by the square of the number of meters of height25 (link). The ratio of TG/HDL-C was measured by dividing the fasting triglyceride level (mmol/L) into the fasting High-density lipoprotein cholesterol level (mmol/L). Gastroenterologists diagnose fatty liver by reviewing abdominal ultrasound based on four known criteria (liver brightness, liver, and kidney echo contrast, vascular blurring, and depth attenuation)26 (link).
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Publication 2023
Abdomen Blood Vessel Body Weight Diagnosis ECHO protocol Ethanol Ex-Smokers Fatty Liver Gastroenterologist Hematologic Tests High Density Lipoprotein Cholesterol Index, Body Mass Kidney Light Liver Non-Smokers Physical Examination Triglycerides Ultrasonics

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More about "Ex-Smokers"

Former smokers, tobacco cessation, smoking abstinence, relapse prevention, research protocols, reproducibility, accuracy, PubCompare.ai, AI-driven platform, literature, pre-prints, patents, data analysis, statistical software, SAS 9.4, SPSS 24, SPSS 21, Stata 11, SPSS Statistics 25, Stata 13, digital scales.
Ex-smokers face unique challenges in maintaining their abstinence and preventing relapse.
PubCompare.ai's AI-driven platform can assist ex-smokers in optimizing their research protocols, ensuring reproducibility and accuracy.
The platform enables users to locate relevant protocols from literature, pre-prints, and patents, and leverages AI-driven comparisons to identify the best protocols and products.
This takes the guesswork out of research, empowering ex-smokers to make informed decisions and achieve their health goals.
With PubCompare.ai's powerful tools, ex-smokers can navigate the complexities of their journey with confidence and ease.
The platform also integrates with popular statistical software like SAS 9.4, SPSS 24, SPSS 21, Stata 11, SPSS Statistics 25, and Stata 13, allowing ex-smokers to analyze their data and track their progress with precision.
Digital scales can also be used in conjunction with the platform to monitor weight changes during the smoking cessation process.
By leveraging the latest technology and data-driven insights, PubCompare.ai helps ex-smokers optimize their research protocols, stay on track, and achieve their health goals.