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Legal Guardians

Legal guardians are individuals appointed by the court to make decisions and act on behalf of another person who is unable to do so themselves, such as a minor or an adult with diminished capacity.
They have the legal authority to manage the person's finances, healthcare, and other important matters.
This description outlines how PubCompare.ai can empower legal guardians by optimizing their research protocols through AI-driven comparisons, helping them locate the best protocols and products from literature, preprints, and patents.
This innovative tool can improve the research process and ensure accurate results, enhancing the guardians' ability to make informed decisions on behalf of their ward.

Most cited protocols related to «Legal Guardians»

Information on social contacts was obtained using cross-sectional surveys conducted by different commercial companies or public health institutes in Belgium (BE), Germany (DE), Finland (FI), Great Britain (GB), Italy (IT), Luxembourg (LU), The Netherlands (NL), and Poland (PL). The recruitment and data collection were organised at the country level according to a common agreed quota sampling methodology and diary design. The surveys were conducted between May 2005 and September 2006 with the oral informed consent of participants and approval of national institutional review boards following a small pilot study to test feasibility of the diary design and recruitment [26 ].
Survey participants were recruited in such a way as to be broadly representative of the whole population in terms of geographical spread, age, and sex. In BE, IT, and LU, survey participants were recruited by random digit dialling using land line telephones; in GB, DE, and PL survey participants were recruited through a face-to-face interview; survey participants in NL and FI were recruited via population registers and linked to a larger national sero-epidemiology survey in NL. Children and adolescents were deliberately oversampled, because of their important role in the spread of infectious agents. For more details on the survey methodology in the various countries, see Table S1.
Briefly, only one person in each household was asked to participate in the study. Paper diaries were either sent by mail or given face to face to participants. Participants were coached by telephone or in person on how to fill in the diary.
Diaries recorded basic sociodemographic information about the participant, including employment status, level of completed education, household composition, age, and sex. Participants were assigned a random day of the week to record every person they had contact with between 5 a.m. and 5 a.m. the following morning. Participants were instructed to record contacted individuals only once in the diary. A contact was defined as either skin-to-skin contact such as a kiss or handshake (a physical contact), or a two-way conversation with three or more words in the physical presence of another person but no skin-to-skin contact (a nonphysical contact). Participants were also asked to provide information about the age and sex of each contact person. If the age of a contact person was not known precisely, participants were asked to provide an estimate of the age range (the midpoint was used for data analysis). For each contact, participants were asked to record location (home, work, school, leisure, transport, or other), the total duration of time spent together (less than 5 min, 5–15 min, 15 min to 1 h, 1–4 h, or 4 h or more) as well as the frequency of usual contacts with this individual (daily or almost daily, about once or twice a week, about once or twice a month, less than once a month, or for the first time).
Diaries were translated into local languages (see Text S1 for the diary used in GB) and are available on request in the following languages: Dutch, English, French, Finnish, German, Italian, Polish, Portuguese, and Swedish. Diaries for young children were filled in by a parent or guardian on their behalf. Older children who obtained parental consent were given diaries with simplified language to fill in on their own (see Table S1 for more details).
Publication 2008
Adolescent Child Ethics Committees, Research Face Fingers Households Infection Legal Guardians One-Person Household Parent Physical Examination Skin
Ethical approval was obtained from the local Medical research Ethics Committees United (MEC-U). The trial was undertaken in accordance with the Good Clinical Practice guidelines established by the International Conference on Harmonization and with the Declaration of Helsinki. Written informed consent was obtained from both parents or guardians and subjects aged ≥12 years before enrollment. This study was registered at the EU Clinical Trials database (EudraCT number: 2013–001823-38) and at the Dutch Trial Register (www.trialregister.nl; NTR4430).
Publication 2019
Conferences Legal Guardians Parent Regional Ethics Committees
The Children with HIV Early Antiretroviral Therapy (CHER) trial is a phase 3, randomized, open-label trial conducted by the Comprehensive International Program for Research in AIDS — South Africa in collaboration with the Medical Research Council Clinical Trials Unit, United Kingdom, and the Division of AIDS (DAIDS) of the National Institutes of Health (NIH). The study is being conducted in two centers in South Africa: the Perinatal HIV Research Unit, Chris Hani Baragwanath Hospital, in Soweto, and the Children's Infectious Diseases Clinical Research Unit, Tygerberg Children's Hospital, in Cape Town.
We enrolled infants 6 to 12 weeks of age who had HIV infection (defined by a positive polymerase-chain-reaction [PCR] test for HIV-1 DNA and a plasma HIV-1 RNA level on PCR of >1000 copies per milliliter) and a CD4 percentage of 25% or more. Exclusion criteria are listed in the Supplementary Appendix, available with the full text of this article at www.nejm.org. Infants were randomly assigned to receive one of three treatments: early limited antiretroviral therapy for 96 weeks, early limited antiretroviral therapy for 40 weeks, or deferred therapy. Immunologic criteria for initiating antiretroviral therapy in the deferred-therapy group or reinitiating antiretroviral therapy in the early-therapy groups were a CD4 percentage of less than 20%5 or, in the case of children younger than 12 months, a CD4 percentage of less than 25% or a CD4 count of less than 1000 cells per cubic millimeter, according to World Health Organization (WHO) guidelines updated in 2006.6 Clinical criteria for initiating or reinitiating antiretroviral therapy7 were Centers for Disease Control and Prevention (CDC) stage C or investigator-selected (severe) stage B events (see the Supplementary Appendix), including symptomatic lymphoid interstitial pneumonitis, bronchiectasis, nephropathy, cardiomyopathy, and failure to thrive. GlaxoSmithKline provided lamivudine and zidovudine, and the South African Department of Health provided lopinavir–ritonavir. Written informed consent was obtained from the parents or legal guardians of all the infants. The authors vouch for the completeness and accuracy of the data.
Publication 2008
Acquired Immunodeficiency Syndrome Bronchiectasis Cardiomyopathies CD4+ Cell Counts Cells Child Communicable Diseases Cuboid Bone Early Therapy Failure to Thrive Group Therapy HIV-1 HIV Infections Infant Kidney Diseases Lamivudine Legal Guardians lopinavir-ritonavir drug combination Lymphoid Interstitial Pneumonia Parent Plasma Polymerase Chain Reaction Southern African People Therapeutics Youth Zidovudine
The NCS-A fieldwork was carried out by the same professional national field interview staff from the Survey Research Center (SRC) at the University of Michigan that carried out the NCS-R. There were 197 interviewers supervised by a team of 18 experienced regional supervisors. A study manager located at the central SRC facility in Michigan oversaw the work of the supervisors and their staff. Upon making in-person contact, the interviewer answered questions before obtaining written informed consent from the parent and then written informed assent from the adolescent. Interviews were never conducted with a non-emancipated adolescent unless at least one parent or guardian was present in the home during the interview. However, no parent consent was requested in the small number of cases where we interviewed an emancipated minor. Adolescents were paid $50 for participating in the survey. The Human Subjects Committees of both Harvard Medical School and the University of Michigan approved these recruitment, consent, and field procedures.
Publication 2009
Adolescent Homo sapiens Interviewers Legal Guardians Parent

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Publication 2013
Adult Child Healthy Volunteers Legal Guardians Mental Disorders Psychotropic Drugs

Most recents protocols related to «Legal Guardians»

From June 2019 to April 2021, patients with metastatic cervical cancer who received ICI retreatment at the Cancer Center, Union Hospital, Huazhong University of Science and Technology, Wuhan, China, were enrolled in this study. The inclusion criteria were as follows: (1) pathologically confirmed squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma of the cervix; (2) metastatic cervical cancer; (3) achieved complete response (CR), partial response (PR), or stable disease (SD) as the best clinical response to first-course immunotherapy; (4) received at least two cycles of retreatment with triplet combination therapy including PD-1 inhibitor, chemotherapy, and antiangiogenic agent; (5) had at least one measurable lesion according to the Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1; and (6) Eastern Cooperative Oncology Group performance score of 1 or less. Patients who did not have the follow-up data were excluded from the analyses. Baseline clinicopathological data, including age, histology, initial stage, metastatic sites, primary surgery, lines of prior systemic treatment, and immunotherapy regimens, were retrieved from medical records.
This retrospective study was conducted in accordance with the principles embodied in the 1964 Declaration of Helsinki and was approved by the Ethics Committee of the Union Hospital of the Huazhong University of Science and Technology (20220023). Informed consent was obtained from all the participants or their legal guardians if the participants cannot write.
Publication 2023
Adenocarcinoma Angiogenesis Inhibitors Cervical Cancer Combined Modality Therapy Ethics Committees, Clinical Immunotherapy Legal Guardians Malignant Neoplasms Neck Neoplasm Metastasis Neoplasms Operative Surgical Procedures Patients Pharmacotherapy Programmed Cell Death Protein 1 Inhibitor Retreatments Squamous Cell Carcinoma Treatment Protocols Triplets Vitelliform Macular Dystrophy
Seven tissue samples from of SCC and seven samples of healthy cervical tissue were used for microarray testing. Additionally, cervical tissue samples from 11 cases of chronic cervicitis, 16 cases of low-grade squamous intraepithelial lesion (LSIL), 20 cases of high-grade squamous intraepithelial lesion (HSIL), and 21 cases of cervical cancer were used to detect hsa_circ_0000276 expression. All samples were single HPV16-positive. From January 2019 to January 2022, samples were obtained from patients who underwent colposcopy at the Second Hospital of the Shanxi Medical University. The tissue specimens were independently diagnosed by two experienced clinical pathologists.
The inclusion criteria were as follows: (i) married women aged ≤ 65 years; (ii) residents of Taiyuan for > 1 year; and (iii) written informed consent provided. The exclusion criteria were as follows: (i) pregnant women; (ii) a history of hysterectomy; (iii) a history of treatment of cervical and vaginal diseases; and (iv) presence of other malignant tumors. Written informed consent was obtained from all study participants or their legal guardians. The Ethics Review Committee of the Second Hospital of the Shanxi Medical University approved this study [approval number (2019) YX No. (280)].
The operational protocol for cervical tissue collection was as follows. The doctor who performed the examination had > 2 years of experience. The lesion site was assessed, and if cervical cancer was considered, tissue was collected from: (1) the cancer site (two pieces of tissue [each approximately 5 mm in size] were clamped) and (2) the matching normal tissues (two pieces of tissues [each approximately 5 mm in size] were clamped at approximately 3–5 cm from the cancer site). After clamping, the tissues were placed in 10% neutral formalin for 6–12 h for fixation and processed within 24 h for routine pathological examination. The tissues were then collected in pre-cooled tubes and quickly snap frozen in liquid nitrogen.
Publication 2023
Cervical Cancer Colposcopy Formalin Freezing High-Grade Squamous Intraepithelial Lesions Human papillomavirus 16 Hysterectomy Legal Guardians Low-Grade Squamous Intraepithelial Lesions Malignant Neoplasms Microarray Analysis Neck Nitrogen Pathologists Patients Physicians Pregnant Women Tissues Uterine Cervicitis Vaginal Diseases Woman
The study was approved by the Medical Science Research Ethics Committee of the First Affiliated Hospital of China Medical University (approval reference number [2012]25–1). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. All participants provided written informed consent by themselves or by their parents/guardians if they were under 18 years old after a complete description of the study. SZ and GHR participants were recruited from the inpatient and outpatient services at Shenyang Mental Health Center and the Department of Psychiatry at First Affiliated Hospital of China Medical University. Healthy controls (HC) participants were recruited from the local community by advertisement.
All components of the study were conducted at a single site and included both longitudinal and cross-sectional study cohorts, aged 13–45 years. All participants were evaluated by 2 trained psychiatrists to determine the presence or absence of Axis I psychiatric diagnoses using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-IV-Text Revision (DSM-IV) Axis I Disorders (SCID) in those 18 years old and older and the Schedule for Affective Disorders and Schizophrenia for School-Age Children-present and Lifetime Version (K-SADS-PL) in those younger than 18 years. SZ participants met DSM-IV diagnostic criteria for SZ and not any other Axis I disorder. GHR participants were first-degree relatives of individuals with SZ and did not meet criteria for any DSM-IV Axis I disorder. HC participants did not have current or lifetime Axis I disorder or history of psychotic, mood, or other Axis I disorders in first-degree relatives as determined by detailed family history. Participants were excluded if any of the following were present: (1) the existence of substance/alcohol abuse or dependence or concomitant major medical disorder, (2) any magnetic resonance imaging (MRI) contraindications, and (3) history of head trauma with loss of consciousness for ≥ 5 min or any neurological disorder. Symptom severity was measured using the Brief Psychiatric Rating Scale (BPRS).
Publication 2023
Abuse, Alcohol Child concomitant disease Craniocerebral Trauma Diagnosis Diagnosis, Psychiatric Epistropheus Ethics Committees, Research Healthy Volunteers Homo sapiens Inpatient Legal Guardians Mental Disorders Mental Health Services Mood Mood Disorders Nervous System Disorder Outpatients Parent Psychiatrist Sadness Schizophrenia SCID Mice Youth
To the best of our knowledge a validated, widely-implemented, objective, tool to evaluate outcome of such procedures in children is yet to be established. However, to enable comparability of our results with those reported previously, we have used a modified version of the assessment tool developed by Percival et al. [13 (link), 14 (link)]. We also evaluated whether MTP transfer impacts on hand dominancy and assessed whether patients showed preference for using the hand that was operated on. The sensibility was examined and recorded in terms of having a two-point discriminatory capacity of < 5 mm.
We certify that all applicable institutional and governmental regulations concerning the ethical use of human volunteers were followed during this research. Informed written consent was obtained from all participants parents and the Ethical Committee of Tehran University of Medical Sciences approved this study. Parents of the children of whom pictures or videos are to be published have given their written consent. The study protocol conforms to the ethical guidelines of the 1975 Declaration of Helsinki.
The parents/guardians of the children provided informed written consent to participate. We obtained consent for publication from the parents/guardians of the children included in the study to publish the photos of participants.
Publication 2023
Child Human Volunteers Legal Guardians Parent Patients
Sixty-three children and adolescents (38 ASD, 25 TD, 7–14 years) were recruited for this neuroimaging study at the Hospital for Sick Children (SickKids), between 2011 and 2013 (Vogan et al., 2019 (link)). All participants were invited back two years later (9–16 years) for a follow-up study. Of the 63 participants, 18 (12 ASD, 7 TD) did not return for the follow-up study due to relocation, declined to participate, had contraindications for MEG (e.g., braces), or were lost to follow-up. MEG data from 13 additional participants (10 ASD and 3 TD) were excluded from analyses due to a) sex matching; b) <20 clean MEG trials; and c) <55% task accuracy. Thus, the final sample consisted of 64 datasets from 17 children with ASD and 15 age- and sex-matched TD controls. The final sample differed slightly for the 2-back memory load condition due to increased task difficulty (58 datasets: 15 ASD, 14 TD). Importantly, as previously reported by Vogan et al. (2019) (link), the participants that returned at follow-up did not significantly differ from those who did not return in terms of age, sex, and IQ. The study protocol was approved by the Research Ethics Board at SickKids. Written informed consent was obtained by a parent or legal guardian, and informed verbal assent was provided by all children. For TD controls, exclusion criteria included a diagnosis of a learning, language or neurodevelopmental disorder; for both groups exclusion criteria also included history of prematurity, severe neurological damage, uncorrected visual impairment or colour blindness and IQ < 70. For children in the ASD group, a primary diagnosis of ASD was confirmed by the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2; Lord et al., 2012 ) by expert clinicians. A summary of the demographic characteristics is shown in Table 1.

Participant demographics.

Time pointASD (n = 17)TD (n = 15)Significance test
M (SD) or countM (SD) or count
Sex (M:F)Baseline15:28:7p = 0.05†
Age (years)BaselineFollow-up11.13 (1.83)13.50 (1.58)10.69 (2.32)12.91 (2.29)t(30) = 0.59, p = 0.56t(30) = 0.85, p = 0.40
ADOS-2BaselineFollow-up6.29 (2.05)7.13 (2.28)

†A Fisher’s exact test was used to test for differences in the proportion of boys and girls between-groups.

Full-scale IQ (FSIQ) was measured using the two sub-test version of the Wechsler Abbreviated Scale of Intelligence (WASI; Wechsler, 2013 (link)) for all children at both time points. FSIQ scores were estimated based on performance on the Vocabulary and Matrix reasoning sub-tests. To assess working memory ability, two sub-tests of the Working Memory Test Battery for Children (WMTB-C) (Gathercole & Pickering, 2000 (link)) were administered (Digit Recall and Block Recall). Parents also completed questionnaires on executive function abilities and social impairment using the Behavior Rating Inventory of Executive Function (BRIEF; Gioia et al., 2000 ) and the Social Responsiveness Scale, Second Edition (SRS-2; Constantino, 2012 ), respectively.
Publication 2023
Adenosine Adolescent Autistic Disorder Blindness, Color Boys Braces Cardiac Arrest Child Diagnosis Executive Function Fingers Intelligence Tests Legal Guardians Low Vision Memory, Short-Term Memory Disorders Neurodevelopmental Disorders Parent Premature Birth Trauma, Nervous System Woman

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More about "Legal Guardians"

Guardians, Caregivers, Court-appointed Fiduciaries, Custodians, Wards, Diminished Capacity, Incapacitated Individuals, Power of Attorney, Probate, Surrogate Decision-Making, Assisted Decision-Making, Conservatorship, Protective Services, Adult Protective Services, Geriatric Care Management, Elder Law, Mental Capacity Assessments, Advance Directives, Living Wills, Healthcare Proxies, Durable Power of Attorney, Asset Management, Financial Management, Estate Planning, Medicaid, Medicare, Long-Term Care, Nursing Homes, Assisted Living, Home Health Aides, Respite Care, Support Groups, Advocacy Organizations.
Legal guardians are court-appointed individuals who have the legal authority and responsibility to make decisions and act on behalf of another person who is unable to do so themselves, such as a minor or an adult with diminished mental capacity.
They play a critical role in managing the individual's finances, healthcare, and other important matters to ensure their well-being and protect their rights.
PubCompare.ai can empower legal guardians by optimizing their research protocols through AI-driven comparisons.
This innovative tool helps guardians locate the best research protocols and products from the literature, preprints, and patents, improving the accuracy and reproducibility of their findings.
By leveraging AI-powered comparisons, guardians can quickly identify the most effective and reliable protocols, enhancing their ability to make informed decisions on behalf of their wards.
For example, guardians may use PubCompare.ai to compare different DNA extraction methods, such as the QIAamp DNA Blood Mini Kit and the QIAamp DNA Mini Kit, to determine the most efficient and accurate approach for their research needs.
They can also compare cell culture media like DMEM and supplements like L-glutamine and Penicillin/streptomycin to ensure they are using the optimal conditions for their ward's specific requirements.
By streamlining the research process and providing AI-driven insights, PubCompare.ai empowers legal guardians to make more informed decisions, ultimately improving the outcomes and quality of life for the individuals they serve.