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Most cited protocols related to «Animal Ethics Committees»

Transgenic Zebrafish Embryo Cultivation

Zebrafish (Danio rerio) embryos were obtained from natural spawning between lysC::EGFP/DsRED2, fli1::EGFP [62 (link)], I-FABP::RFP [41 (link)] and wild type (obtained from the Zebrafish International Resource Center) adult fish. Embryos were raised at 28°C in Embryo Medium (E3) [63 ] and developmentally staged as described [64 (link)]. Research was conducted with approval from The University of Auckland Animal Ethics Committee (AEC/04/2005/R370).

Hall C., Flores M.V., Storm T., Crosier K, & Crosier P. (2007). The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish. BMC Developmental Biology, 7, 42.

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Publication 2007

Adult Animal Ethics Committees Embryo FABP2 protein, human Fishes Zebrafish

Conditional Regulation of Vascular Hypoxia

C57BL/6J males were used for experiments at the age of 2-4 weeks (juvenile), 8-12 weeks (adult) and 57-70 weeks (aged). EC-specific gene deletions were generated using Cdh5(PAC)-CreERT2 transgenic mice, which were interbred with conditional mutants carrying loxP-flanked Hifa35 (link) (Hif1a^lox/lox). To induce Cre activity and gene inactivation, pups were injected with 500μg tamoxifen (Sigma, T5648) intraperitoneally everyday from P10 to P14. Femurs and tibiae from Cdh5(PAC)-CreERT2^T/+Hif1a^lox/lox (Hif1a^iΔEC) mutants and Cre-negative (Hif1a^lox/lox) controls were collected on P20 or P37 after euthanasia. The same approach was used for experiments involving conditional Vhl mice50 (link). For genetic labelling of metaphyseal vasculature, Cdh5(PAC)-CreERT2^T/+ mice were mated with R26-mG/mT reporters. At P29, Cdh5(PAC)-CreERT2^T/+/R26-mG/mT^T/+ mice received a single dose of 50μg tamoxifen and were analysed either 1 or 40 days later.
All animals were genotyped by PCR. Protocols and primer sequences are provided upon request. When indicated, adult wild-type mice were whole-body irradiated with a single dose of 900 rads (Gammacell irradiator) and sacrificed 7 days later.
For DFM treatment, freshly prepared deferoxamine mesylate (Sigma) in water (15 mg/ml per mouse) was injected intraperitoneally every alternate day for 4 weeks or, for μ-CT analysis, 5 weeks. Control animals received the same amount of sterile water.
For labelling of proliferating cells, mice were intraperitoneally injected with 1.6 mg/kg weight of EdU (Invitrogen) 2 hr before euthanasia. Tibiae were immediately collected and processed. Bone marrow cells and bone sections were stained for EDU using Click-iT chemistry following the manufacturer’s instructions (Invitrogen).
Experiments involving animals were performed according to the institutional guidelines and laws, following protocols approved by local animal ethics committees.

Kusumbe A.P., Ramasamy S.K, & Adams R.H. (2014). Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature, 507(7492), 323-328.

Publication 2014

Adult Animal Ethics Committees Animals Bone Marrow Cells Bones CDH5 protein, human Cells Euthanasia Femur Gene Deletion Gene Silencing Human Body Males Mesylate, Deferoxamine Mice, Laboratory Mice, Transgenic Oligonucleotide Primers Reproduction RRAD protein, human Sterility, Reproductive Tamoxifen Tibia

Adoptive Transfer of Antigen-Specific B Cells

SW_HEL (25 (link)), SW_HEL.rag1^−/− (28 (link)), and SW_HEL(H) (24 (link)) mice have been described previously. WT C57BL/6 and CD45.1 congenic C57BL/6 mice were obtained from the Animal Resources Centre (Perth, Australia). All mice were maintained on a C57BL/6 background and housed in specific pathogen–free environment. All experimental procedures were approved by the University of Sydney Animal Ethics Committee. B cell isolation, CFSE labeling, and conjugation of HEL to SRBC were performed as described previously (6 (link)). SRBC conjugations were performed using recombinant WT or mutant HEL at 100 μg/ml unless otherwise indicated (Fig. 6). For adoptive transfers, spleen or lymph node cells from SW_HEL or SW_HEL(H) donor mice containing 10⁴ HEL-binding B cells were injected intravenously into male CD45.1 congenic C57BL/6 recipients together with 2 × 10⁸ SRBC conjugated to a specific recombinant HEL protein. Mock-conjugated SRBC in which HEL was omitted from the conjugation reaction served as a control antigen. No additional adjuvant was used in the immunizations. Mice receiving only HEL-conjugated SRBCs intravenously did not produce detectable anti-HEL serum antibodies, presumably because of the low frequency of anti-HEL B cells present in the absence of transferred SW_HEL B cells.

Paus D., Phan T.G., Chan T.D., Gardam S., Basten A, & Brink R. (2006). Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation. The Journal of Experimental Medicine, 203(4), 1081-1091.

Publication 2006

5-(6)-carboxyfluorescein diacetate succinimidyl ester Adoptive Transfer Animal Ethics Committees Animals Anti-Antibodies Antigens B-Lymphocytes Cell Separation Immunization isolation Lymphocyte Males Mice, Congenic Mus Pharmaceutical Adjuvants RAG-1 Gene Recombinant Proteins Serum Specific Pathogen Free Spleen Staphylococcal Protein A Tissue Donors

Genetic Manipulation of Notch Signaling in Bone

For wild-type bone analysis, C57BL/6J male mice were used unless stated otherwise. All EC-specific gene targeting experiments were performed with Cdh5(PAC)-CreERT2 transgenic mice24 (link). For Rbpj deletion in the postnatal endothelium, mice carrying loxP-flanked Rbpj (Rbpj^lox/lox) alleles25 (link) and Cdh5(PAC)-CreERT2 transgenics were interbred. To induce Cre activity and gene deletion, offspring was injected with 500µg tamoxifen (Sigma, T5648) intraperitoneally every day from P10 to P14. The resulting Rbpj^iΔEC (CreERT2^T/+Rbpj^lox/lox) mutants and Cre- littermate controls were sacrificed at P28, and femurs and tibiae were collected for analysis. Identical breeding and tamoxifen administration strategies were used to generate EC-specific mutants with Fbxw7^lox/lox (Ref.10 (link)), Dll1^lox/lox (Ref. 13 (link)), Dll4^lox/lox (Ref. 14 (link)), or Jag1^lox/lox (Ref. 15 (link)) mice and inducible osteoblast-specific Rbpj knockouts (Rbpj^iOB). The latter were generated with Tg(Col1a1-creERT2)6.1.ICS transgenic mice (Institut Clinique de la Souris, France).
For Notch gain-of-function experiments, Gt(ROSA)26Sor^{tm1(Notch1)Dam/J} mice carrying a Cre-inducible transgene for Notch1 intracellular domain overexpression26 (link) and Cdh5(PAC)-CreERT2 transgenics were interbred. Tamoxifen administration (see above for injection schedule) was used to generate CreERT2-positive (NICD^iOE-EC) mutants overexpressing NICD in ECs and controls. For experiments with EC-specific Dll4^iΔEC/NICD^iOE-EC double mutants, interbreeding of Dll4^lox/lox conditional mice14 (link) with Gt(ROSA)26Sor^{tm1(Notch1)Dam/J} and Cdh5(PAC)-CreERT2 transgenics generated triple heterozygote males, which were bred to Dll4^lox/+Gt(ROSA)26Sor^{tm1(Notch1)Dam/J} double heterozygous females. This produced CreERT2-negative controls together with Dll4^lox/lox NICD^+/+CreERT2^T/+ (Dll4^iΔEC) and Dll4^+/+ NICD^+/OECreERT2^T/+ (NICD^iOE-EC) single mutants, and Dll4^iΔEC/NICD^iOE-EC double mutants, which received tamoxifen and were analysed as described above. For mutant analysis, both male and female mice were used.
For Noggin administration experiments, mice were injected intraperitoneally once daily with 500µg/kg recombinant Noggin (R&D Systems) from P15 to P27, after completion of tamoxifen injections (P10-P14) and before analysis at P28.
All animal experiments were performed in compliance with the relevant laws and institutional guidelines and were approved by local animal ethics committees.

Ramasamy S.K., Kusumbe A.P., Wang L, & Adams R.H. (2014). Endothelial Notch activity promotes angiogenesis and osteogenesis in bone. Nature, 507(7492), 376-380.

Publication 2014

Animal Ethics Committees Animals, Transgenic Bones CDH5 protein, human Deletion Mutation Endothelium Females Femur Gene Deletion Heterozygote Males Mice, Inbred C57BL Mice, Laboratory Mice, Transgenic noggin protein Osteoblasts Protoplasm RBPJ protein, human Rosa Tamoxifen Tibia Transgenes

Chick Embryo Xenograft Model for Ovarian Cancer

Fertilized white leghorn chicken eggs were obtained from Hi-Chick, South Australia, Australia. Eggs were incubated in a MultiQuip Incubator (E2) at 37 °C with 60% humidity. Ethics approval was obtained by the University of Adelaide Animal Ethics Committee. A small window was made in the shell on day 3 of chick embryo development under aseptic conditions. The window was resealed with adhesive tape and eggs were returned to the incubator until day 11 of chick embryo development. On day 11, OVCAR-3, SKOV-3 and OV-90 cell suspensions (9 × 10⁵) were mixed with growth factor reduced matrigel (8.9 mg/mL, BD Biosciences, NSW, Australia) in a total volume of 30 μL. Control anti-mouse IgG (20 μg/mL) (Sigma Aldrich) and neutralizing antibody to protein A (20 μg/mL) (BD Biosciences) were mixed together with the OV-90 cancer cells and matrigel. Matrigel grafts were placed on top of the CAM and eggs were resealed and returned to the incubator for 72 hours until day 14 (n = 6 chicken embryos per cell line). Matrigel grafts with surrounding CAM were harvested from each embryo and fixed with 4% paraformaldehyde for 24 hours and embedded in paraffin. Serial sections (6 μm) were stained with hematoxylin and eosin. Slides were digitally scanned using the NanoZoomer (Hamamatsu Photonics K.K., Japan).

Lokman N.A., Elder A.S., Ricciardelli C, & Oehler M.K. (2012). Chick Chorioallantoic Membrane (CAM) Assay as an In Vivo Model to Study the Effect of Newly Identified Molecules on Ovarian Cancer Invasion and Metastasis. International Journal of Molecular Sciences, 13(8), 9959-9970.

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Publication 2012

Animal Ethics Committees anti-IgG Antibodies, Neutralizing Asepsis Cell Lines Cells Chickens Eggs Embryo Embryonic Development Eosin Grafts Growth Factor Humidity Malignant Neoplasms matrigel Mus Paraffin Embedding paraform Staphylococcal Protein A Zygote

Most recents protocols related to «Animal Ethics Committees»

Acclimation and Welfare of C57Bl/6J Mice

Eight-week-old male C57Bl/6J mice were obtained from Wei Tong Li Hua Biotechnology Co. (Beijing, China) and housed in a specific-pathogen-free facility (22 °C, 12 h/12 h light–dark cycle) in the laboratory animal center of Tongji Medical College. All mice were allowed to adapt to the laboratory conditions for 2 weeks with free access to food and sterile water. The animal studies were approved by the Animal Ethics Committee of Tongji Medical College of Huazhong University of Science and Technology, and the works were conducted in accordance with the principles of the Animal Care and Use Committee of this institution.

Yang J., Wang L., Mei M., Guo J., Yang X, & Liu S. (2023). Electroacupuncture repairs intestinal barrier by upregulating CB1 through gut microbiota in DSS-induced acute colitis. Chinese Medicine, 18, 24.

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Publication 2023

Animal Ethics Committees Animals Animals, Laboratory Food Males Mice, House Mice, Inbred C57BL Specific Pathogen Free Sterility, Reproductive

Histological Analysis of African and South American Lungfish Olfactory Organs

All procedures were approved by the local Animal Ethics Committee of Iwate University. The African lungfish P. aethiopicus and South American lungfish, L. paradoxa, were purchased from commercial suppliers. The fishes were anesthetized with tricaine methanesulfonate and euthanized by decapitation. Information pertaining to the animals is shown in Table 1. Juvenile and adult individuals of each lungfish were used. According to Mlewa and Green (2004) [29 (link)] and Jorgensen and Joss (2010) [30 ], P. aethiopicus individuals over 43 cm in body length (BL) reach sexual maturity. Thus, P. aethiopicus #1 (BL 50 cm) and L. paradoxa #1 (BL 65 cm) were regarded as adults, whereas P. aethiopicus #2–4 and L. paradoxa #3 (BL 35 cm or less) were regarded as juveniles [29 (link), 30 ]. Also, we confirmed during dissection whether they had functional genital organs or not.Table 1

Animals

	Animal No	Total body length (cm)	Body weight (g)	Sex	Application
P. aethiopicus	1	50.0	349.0	F	ISH (left)/RNA extraction (right)
	2	35.0	150.6	M	Dice CT
	3	31.5	100.0	unknown	ISH
	4	34.0	118.3	F	SEM
L. paradoxa	1	65.0	994.5	F	RNA extraction (left)/ISH (right)
L. paradoxa	3	18.5	18.6	M	ISH

ISH in situ hybridization; Dice CT Diffusible iodine-based contrast-enhanced computed tomography; SEM Scanning Electron Microscopy

For histological examination, olfactory organs were dissected from the heads and fixed in 4% paraformaldehyde in 0.1 M phosphate buffer (PB, pH 7.4). The specimens were cryoprotected in a sucrose gradient (10%, 20%, and 30% in 0.1 M PB), embedded in O.C.T. compound (Sakura Finetek, Tokyo, Japan), and sectioned sagittally using a cryostat. Sections (20 µm in thickness) were thaw mounted on MAS-coated slides (Matsunami, Osaka, Japan), air-dried, and processed for hematoxylin–eosin staining, immunohistochemistry, and in situ hybridization.

Nakamuta S., Yamamoto Y., Miyazaki M., Sakuma A., Nikaido M, & Nakamuta N. (2023). Type 1 vomeronasal receptor expression in juvenile and adult lungfish olfactory organ. Zoological Letters, 9, 6.

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Publication 2023

Adult Animal Ethics Committees Animals Body Weight Buffers Decapitation Dissection Electrons Eosin Fishes Genitalia Head Human Body Immunohistochemistry In Situ Hybridization Iodine methanesulfonate Negroid Races paraform Phosphates Sense of Smell Sexual Maturation South American People Sucrose tricaine X-Ray Computed Tomography

Animal Ethics-Approved Biodiversity Study

The authors followed all appropriate ethical and legal guidelines and regulations. The Chengdu Institute of Biology, Chinese Academy of Sciences (CIB, CAS), facilitated the collection and exportation permits necessary for this and related studies. The study was approved by the Animal Ethics Committee of Chengdu Institute of Biology, Chinese Academy of Sciences (CIBDWLL20202632, 13 April 2020). Research procedures were carried out in accordance with all national and institutional regulations.

Tang C.Y., Zhang X., Xu X., Sun S., Peng C., Song M.H., Yan C., Sun H., Liu M., Xie L., Luo S.J, & Li J.T. (2023). Genetic mapping and molecular mechanism behind color variation in the Asian vine snake. Genome Biology, 24, 46.

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Publication 2023

Animal Ethics Committees Chinese

Evaluation of Female Bama Miniature Pigs and C57BL/6 Mice

Protocol full text hidden due to copyright restrictions

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Publication 2023

Animal Ethics Committees Animals Animals, Laboratory Females Food Mice, Inbred C57BL Sus scrofa

Ethical Animal Research Protocol

This study was conducted in accordance with the Guidelines for the Care and Use of Animals in Research published by the Institute of Zoology, Chinese Academy of Sciences. This study was reviewed and approved by the Animal Ethics Committee of the Institute of Zoology, Chinese Academy of Sciences (2019FY100300-03).

Hu B., Wang J., Li Y., Ge J., Pan J., Li G., He Y., Zhong H., Wang B., Huang Y., Han S., Xing Y, & He H. (2023). Gut microbiota facilitates adaptation of the plateau zokor (Myospalax baileyi) to the plateau living environment. Frontiers in Microbiology, 14, 1136845.

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Publication 2023

Animal Ethics Committees Animals Chinese

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What are Animal Ethics Committees and what is their role in animal research?

Animal Ethics Committees (AECs) are regulatory bodies that review and approve research protocols involving the use of animals. Their primary role is to ensure that animal studies are conducted in an ethical and humane manner, while also balancing the scientific merits of the research. AECs evaluate proposed studies to minimize animal suffering and uphold animal welfare standards.

How can PubCompare.ai's platform assist Animal Ethics Committees in their work?

PubCompare.ai's AI-driven platform can greatly assist Animal Ethics Committees in several ways. First, it allows committees to screen protocol literature more efficiently by providing access to a comprehensive database of studies, pre-prints, and patents. Second, the platform's AI-powered analysis can help identify critical insights, such as key differences in protocol effectiveness, enabling committees to choose the most appropriate and reproducible methods for their research needs. This helps committees make more informed decisions to uphold animal welfare while supporting robust scientific investigations.

What are the different types of Animal Ethics Committees and how do they vary in their responsibilities?

Animal Ethics Committees can vary in their structure and responsibilities depending on the jurisdiction and the type of research institution they serve. Generally, there are institutional AECs that review protocols for research conducted within a specific organization, as well as central or national AECs that provide oversight for a broader range of animal studies. The composition and review processes of these committees may differ, but they all share the common goal of ensuring ethical and humane animal research.

How can PubCompare.ai help Animal Ethics Committees identify the most effective protocols for specific research goals?

PubCompare.ai's AI-driven platform is designed to help Animal Ethics Committees pinpoint the most effective protocols for their researchers' specific needs. By leveraging machine learning algorithms, the platform can analyze and compare a vast number of research protocols, identifying key differences in their effectiveness, reproducibility, and animal welfare considerations. This enables AECs to make more informed decisions when reviewing and approving protocols, ensuring that the selected methods are optimal for the research objectives while prioritizing animal welfare.

What are some common challenges faced by Animal Ethics Committees and how can PubCompare.ai address them?

One of the key challenges faced by Animal Ethics Committees is the sheer volume of research protocols they need to review and evaluate. This can be a time-consuming and resource-intensive process. PubCompare.ai's platform can help address this challenge by providing AECs with a centralized database of protocols, as well as AI-driven tools to quickly identify and compare the most relevant and effective methods. This streamlines the review process and helps committees make more informed decisions, ultimately enhancing the efficiency and quality of animal research oversight.

More about "Animal Ethics Committees"

Animal Ethics Committees play a crucial role in ensuring the ethical and humane treatment of animals used in research, including studies involving BALB/c nude mice, C57BL/6 mice, C57BL/6J mice, Sprague-Dawley rats, and other common animal models.
These committees review research protocols, assess potential risks and benefits, and work to minimize animal suffering while advancing scientific knowledge.
The use of cell culture media, such as DMEM, and supplements like FBS, Penicillin/streptomycin, and Matrigel, are often integral components of animal research protocols.
Animal Ethics Committees carefully evaluate the use of these materials to ensure they are necessary and used responsibly.
In the context of diabetes research, the administration of STZ (Streptozotocin) to induce hyperglycemia in rodent models is a common practice that requires the oversight of Animal Ethics Committees.
These committees ensure that the dosage, administration methods, and monitoring procedures are appropriate and in line with ethical guidelines.
PubCompare.ai's AI-driven platform can optimize research protocols and enhance reproducibility for Animal Ethics Committees.
The intuitive tool helps locate relevant protocols from literature, pre-prints, and patents, and leverages AI-driven comparisons to identify the best protocols and products.
This streamlines the research process and supports the committees' efforts to ensure the ethical and efficient use of animal models.
By utilizing PubCompare.ai, Animal Ethics Committees can access a wealth of information, make informed decisions, and promote the responsible use of animals in research.
This technology empowers committees to uphold the highest standards of animal welfare while advancing scientific discoveries.