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Ethics Committees, Research

Ethics Committees, Research: Specialized groups that review research protocols and projects involving human subjects to ensure adherence to applicable laws, regulations, and ethical principles.
These committees help protect the rights and welfare of study participants, while also supporting researchers in making informed, data-driven decisions.
By providing objective, peer-reviewed assessments, ethics committees play a crucial role in enhancing the quality, transparency, and reproducibility of biomedical research.

Most cited protocols related to «Ethics Committees, Research»

1
Comprehensive Multi-Omics Profiling of Breast Cancer
Specimens were obtained from patients with appropriate consent from institutional review boards. Using a co-isolation protocol, DNA and RNA were purified. In total, 800 patients were assayed on at least one platform. Different numbers of patients were used for each platform using the largest number of patients available at time of data freeze; 466 samples (463 patients) were in common across 5/6 platforms (excluding RPPA) and 348 patients were in common on 6/6 platforms. Technology platforms used include: 1) gene expression DNA microarrays51 (link), 2) DNA methylation arrays, 3) microRNA sequencing, 4) Affymetrix SNP arrays, 5) exome sequencing, and 6) Reverse Phase Protein Arrays. Each platform, except for the exome sequencing, was used in a de novo subtype discovery analysis (Supplemental Methods) which were included in a single analysis to define an overall subtype architecture. Additional integrated across platform computational analyses were preformed including PARADIGM32 (link) and MEMo40 (link).
All of the primary sequence files are deposited in CGHub (https://cghub.ucsc.edu/); all other data including mutation annotation file are deposited at the Data Coordinating Center (DCC) (http://cancergenome.nih.gov/). Sample lists, data matrices and supporting data can be found at (http://tcga-data.nci.nih.gov/docs/publications/brca_2012/). The data can be explored via the ISB Regulome Explorer (http://explorer.cancerregulome.org/) and the cBio Cancer Genomics Portal (http://cbioportal.org). Data descriptions can be found at (https://wiki.nci.nih.gov/display/TCGA/TCGA+Data+Primer) and in Supplementary Methods. Reprints and permissions information is available at www.nature.com/reprints.
Comprehensive molecular portraits of human breast tumors. (2012). Nature, 490(7418), 61-70.
Publication 2012
DNA Chips Ethics Committees, Research Freezing Gene Expression isolation Malignant Neoplasms Methylation MicroRNAs Mutation Oligonucleotide Primers Patients Protein Arrays
2
Genomic and Transcriptional Profiling of Patients
All patient specimens were obtained with appropriate consent from the relevant institutional review board. DNA and RNA were isolated from samples and hybridized to the Affymetrix SNP 6.0 and Illumina HT-12 v3 platforms for genomic and transcriptional profiling, respectively. A detailed description of the experimental assays and analytical methods used to analyse these data are available in the Supplementary Information.
Curtis C., Shah S.P., Chin S.F., Turashvili G., Rueda O.M., Dunning M.J., Speed D., Lynch A.G., Samarajiwa S., Yuan Y., Gräf S., Ha G., Haffari G., Bashashati A., Russell R., McKinney S., Langerød A., Green A., Provenzano E., Wishart G., Pinder S., Watson P., Markowetz F., Murphy L., Ellis I., Purushotham A., Børresen-Dale A.L., Brenton J.D., Tavaré S., Caldas C, & Aparicio S. (2012). The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature, 486(7403), 346-352.
Publication 2012
Biological Assay Ethics Committees, Research Genome Patients Transcription, Genetic
3
Genomic and Transcriptional Profiling of Patients
All patient specimens were obtained with appropriate consent from the relevant institutional review board. DNA and RNA were isolated from samples and hybridized to the Affymetrix SNP 6.0 and Illumina HT-12 v3 platforms for genomic and transcriptional profiling, respectively. A detailed description of the experimental assays and analytical methods used to analyse these data are available in the Supplementary Information.
Curtis C., Shah S.P., Chin S.F., Turashvili G., Rueda O.M., Dunning M.J., Speed D., Lynch A.G., Samarajiwa S., Yuan Y., Gräf S., Ha G., Haffari G., Bashashati A., Russell R., McKinney S., Langerød A., Green A., Provenzano E., Wishart G., Pinder S., Watson P., Markowetz F., Murphy L., Ellis I., Purushotham A., Børresen-Dale A.L., Brenton J.D., Tavaré S., Caldas C, & Aparicio S. (2012). The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature, 486(7403), 346-352.
Publication 2012
Biological Assay Ethics Committees, Research Genome Patients Transcription, Genetic
4
Epidemiological Collaboration on Kidney Disease
The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) is a research group established by the National Institutes of Diabetes, Digestive and Kidney Disease. The institutional review boards of all participating institutions approved the study.
Levey A.S., Stevens L.A., Schmid C.H., Zhang Y.(., Castro AF I.I.I., Feldman H.I., Kusek J.W., Eggers P., Van Lente F., Greene T, & Coresh J. (2009). A New Equation to Estimate Glomerular Filtration Rate. Annals of internal medicine, 150(9), 604-612.
Publication 2009
Diabetes Mellitus Digestive System Ethics Committees, Research Kidney Diseases
5
CKD-EPI Study of GFR Estimation
The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) conducted the study under a cooperative agreement with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). CKD-EPI collaborators provided data from clinical research studies and clinical populations.3 (link) GFR measurements were based on urinary or plasma clearance of exogenous filtration markers. Data from studies of urinary clearance of iothalamate were used for development and internal validation, and data from studies of other filtration markers were used for external validation. We included 13 studies with 5352 participants, who were randomly divided into separate data sets for development (3522) and internal validation (1830) (see Table S1a in the Supplementary Appendix, available with the full text of this article at NEJM .org). We included 5 other studies with 1119 participants for external validation (Table S1b in the Supplementary Appendix). We excluded studies involving transplant recipients because our preliminary analyses showed large variations among these studies in the relationship between serum cystatin C levels and measured GFR. The institutional review boards of all participating institutions approved the study.
The NIDDK was substantially involved in the design of the study and in the collection, analysis, and interpretation of the data; the NIDDK was not required to approve the final manuscript before submission for publication. The first author had full access to all the data in the study, vouches for the integrity of the data and the accuracy of the data analysis for the CKD-EPI database, and wrote the first draft of the manuscript. For a list of collaborators who provided data, see the Supplementary Appendix.
Inker L.A., Schmid C.H., Tighiouart H., Eckfeldt J.H., Feldman H.I., Greene T., Kusek J.W., Manzi J., Van Lente F., Zhang Y.L., Coresh J, & Levey A.S. (2012). Estimating Glomerular Filtration Rate from Serum Creatinine and Cystatin C. The New England journal of medicine, 367(1), 20-29.
Publication 2012
Diabetic Nephropathy Digestive System Ethics Committees, Research Filtration Iothalamate Plasma Population Group Post-gamma-Globulin Serum Transplant Recipients Urine

Most recents protocols related to «Ethics Committees, Research»

1
Sarilumab for Severe COVID-19 Pneumonia

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Open the protocol to access the free full text link

Publication 2023
Adrenal Cortex Hormones Adult Antiviral Agents Clinical Investigators Communicable Diseases COVID 19 Ethics Committees Ethics Committees, Research Inpatient Patients Pneumonia Safety sarilumab
2
COVID-19 Impact on Allogeneic HSCT
This is retrospective multicenter cohort study promoted by the European Hematology Association – Infections in Hematology Study Working Group (EHA-IDWP; EPICOVIDEHA survey, https://pubmed.ncbi.nlm.nih.gov/34235404/). Data have been collected on all consecutive adult patients who received an allogeneic HSCT and had COVID-19 in more than 150 European centers between January 2020 and March 2022. Only patients for whom allogeneic HSCT represented the last treatment performed were included into the study. Each institutional review board independently approved the study.
Busca A., Salmanton-García J., Marchesi F., Farina F., Seval G.C., Van Doesum J., De Jonge N., Bahr N.C., Maertens J., Meletiadis J., Fracchiolla N.S., Weinbergerová B., Verga L., Ráčil Z., Jiménez M., Glenthøj A., Blennow O., Tanase A.D., Schönlein M., Prezioso L., Khanna N., Duarte R.F., Žák P., Nucci M., Machado M., Kulasekararaj A., Espigado I., De Kort E., Ribera-Santa Susana J.M., Marchetti M., Magliano G., Falces-Romero I., Ilhan O., Ammatuna E., Zompi S., Tsirigotis P., Antoniadou A., Zambrotta G.P., Nordlander A., Karlsson L.K., Hanakova M., Dragonetti G., Cabirta A., Berg Venemyr C., Gräfe S., Van Praet J., Tragiannidis A., Petzer V., López-García A., Itri F., Groh A., Gavriilaki E., Dargenio M., Rahimli L., Cornely O.A, & Pagano L. (2023). Outcome of COVID-19 in allogeneic stem cell transplant recipients: Results from the EPICOVIDEHA registry. Frontiers in Immunology, 14, 1125030.
Full text: Click here
Publication 2023
Adult COVID 19 Ethics Committees, Research Europeans Infection Patients
3
Swallowing Assessment and Pneumonia Episodes
Spearman’s rank correlation coefficient was used to determine the correlations of the OHAT score with the results of swallowing endoscopy and swallowing angiography. Welch’s t-test was applied for comparisons between the no/single-pneumonia episode group and the multiple-pneumonia episode group.
The study was approved by the Fukuoka Gakuen Research Ethics Committee (permission no. 314).
Yamano T., Nishi K., Omori F., Wada K, & Naito T. (2023). Association Between Oral Health and Swallowing Function in the Elderly. Clinical Interventions in Aging, 18, 343-351.
Publication 2023
Angiography Endoscopy, Gastrointestinal Ethics Committees, Research Pneumonia
4
Hypothyroidism and Autoimmune Markers in Saudi Arabia
The Jazan Research Ethics Committee of the General Directorate of Health Affairs (Jazan), Ministry of Health, Saudi Arabia, approved the current study, which complies with the Declaration of Helsinki. All participants provided written informed consent. A total of 158 age-matched (30–60 years) male and female subjects were recruited for the current case–control study from King Fahad Central Hospital, the outpatient clinic (control), and the Endocrine and Diabetes Center (hypothyroid patients) in the Jazan area of southwest Saudi Arabia. These subjects were chosen at random from a population of Saudis primarily from the Jazan region. Samples were collected during the period from November 2018 to March 2019. At the time of diagnosis, AHT patients had high levels of thyroid-stimulating hormone and low levels of free thyroxine, as well as anti-thyroid peroxidase and/or anti-thyroglobulin autoantibodies. The healthy control group included subjects who had no history of thyroid or other autoimmune diseases, severe illness, or a chronic inflammatory condition.
Habibullah M.M., Hakamy A., Mansor A.S., Atti I.M., Alwadani A.A, & Kaabi Y.A. (2023). The Association of UCP2-866 G/A Genotype with Autoimmune Hypothyroidism in the Southwestern Saudi Arabia Population. International Journal of General Medicine, 16, 875-879.
Publication 2023
anti-thyroglobulin antibody Autoimmune Diseases Diabetes Mellitus Diagnosis Disease, Chronic Ethics Committees, Research Healthy Volunteers Hypothyroidism Inflammation Iodide Peroxidase Males Patients System, Endocrine Thyroid Gland Thyrotropin Thyroxine Woman
5
Cigar Pack Color Influence on Flavor Perceptions
The Rutgers University Institutional Review Board deemed this online survey study exempt because of minimal participant risk. Participants provided consent before survey completion. The study followed the AAPOR reporting guideline.
We examined the association of cigar pack color with consumer flavor perceptions using data from 1 wave of the Rutgers Omnibus Study (a quarterly Amazon Mechanical Turk [mTurk] survey of US adults aged 18–45 years) collected in August 2022. Respondents were randomized to view a cigar with blue or purple packaging and asked if the cigar was flavored (yes or no) and, if yes, what flavor. We used multivariable logistic regression models to examine the association of condition (pack color) with cigar use, self-reported demographic characteristics (age, sex, and race and ethnicity), and flavor perceptions. Statistical significance was defined as P < .05 (2-tailed) and analyses were conducted in October 2022 using Stata/MP, version 17 (StataCorp).
Delnevo C.D, & Ganz O. (2023). Association of Flavor Perception With Blue vs Purple Cigar Packaging Among US Adults. JAMA network open, 6(2), e2254003.
Full text: Click here
Publication 2023
Adult Ethics Committees, Research Ethnicity Flavor Enhancers

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More about "Ethics Committees, Research"

Research Ethics Committees, Institutional Review Boards (IRBs), Human Subject Protections, Biomedical Research Oversight, Clinical Trial Ethics, Pharmaceutical Research Ethics, Preclinical Study Ethics, Randomized Controlled Trials (RCTs), Informed Consent, Participant Welfare, Research Rigor, Reproducibility, Transparency, Quality Assurance, Cell Culture Contaminants (Penicillin/streptomycin, DMEM, Streptomycin, Penicillin, Ficoll-Paque PLUS, RPMI 1640, L-glutamine), SAS Analytics (SAS 9.4), Biospecimen Management, Omics Data Ethics, Artificial Intelligence in Research Ethics.