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Dietary Fats

Dietary fats are a diverse group of lipid molecules that play a crucial role in human nutrition and health.
They provide energy, facilitate the absorption of fat-soluble vitamins, and contribute to the structure and function of cell membranes.
Dietary fats can be classified into various categories based on their degree of saturation, chain length, and other structural features.
The optimal balance and consumption of different dietary fat types, such as saturated, monounsaturated, and polyunsaturated fats, have been the focus of extensive research to understand their impact on cardiovascular health, metabolic processes, and overall well-being.
Undestanding the complex interplay between dietary fats and physiological processes is essential for develping effective nutritional strategies and improving public health outcomes.
PubCompare.ai's AI-driven platform can help researchers optimize their dietary fats research by locating the best protocols from literature, preprints, and patents, while using advanced AI comparisons to enhance reproducibility and accuracy.
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Most cited protocols related to «Dietary Fats»

Allostatic Load and Psychosocial Stress

The BPRHS is an ongoing longitudinal study that aims to examine the role of psychosocial stress on the presence and development of allostatic load (physiological dysregulation) and health outcomes such as depressive symptomatology, cognitive impairment, functional limitations, and metabolic conditions in Puerto Ricans. Further investigation includes the potential modification of these associations by nutritional status, especially for dietary fat, B vitamins and antioxidants, by genetic variation, and by sources and type of social and community support. The study was approved by the Institutional Review Board at Tufts Medical Center and Northeastern University. All participants provided written informed consent.

Tucker K.L., Mattei J., Noel S.E., Collado B.M., Mendez J., Nelson J., Griffith J., Ordovas J.M, & Falcon L.M. (2010). The Boston Puerto Rican Health Study, a longitudinal cohort study on health disparities in Puerto Rican adults: challenges and opportunities. BMC Public Health, 10, 107.

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Publication 2010

Antioxidants Dietary Fats Disorders, Cognitive Ethics Committees, Research Genetic Diversity Metabolic Diseases physiology Puerto Ricans Vitamin B Complex

Stepped Behavioral Weight Intervention

SBWI and STEP were prescribed identical diet and physical activity recommendations. The diet was prescribed to reduce energy intake and dietary fat consumption. Energy intake was prescribed at 1,200 kcal/d for participants ≤90 kg, 1,500 kcal/d for participants >90 kg, or 1,800 kcal/d for participants ≥113 kg. Prescribed kcal/d was adjusted downward for participants if the mean weight loss was less than 0.9 kg per week, the participant had a BMI ≥25 kg/m², and the participant expressed a desire to continue to lose weight. Prescribed kcal/d was adjusted upward in 100 kcal/d increments each week when further weight loss was not indicated (BMI <25 kg/m²) or when the participant expressed to the intervention staff that they no longer desired to lose additional weight. Meal plans were provided to assist with adoption of dietary recommendations. Participants were instructed to self-monitor food intake in a weekly diary, and interventionists provided feedback to the participant in an attempt to maximize adherence to prescribed dietary goals. SBWI returned diaries at intervention sessions, whereas STEP returned diaries at in person sessions but otherwise returned diaries via postal mail.
Prescribed physical activity progressed to 300 min/wk by the end of week 24, with participants encouraged to maintain this dose for the remainder of the 18 months. Intensity was prescribed as moderate-to-vigorous.¹⁴ Participants were instructed to self-monitor their physical activity in a weekly diary that was reviewed by the interventionists and feedback was provided to the participant in an attempt to maximize adherence to the prescribed physical activity recommendations for this study.
SBWI included group-based intervention sessions throughout the 18-month intervention. Sessions were weekly for months 1–6, twice per month during months 7–12, and once per month during months 13–18. Participants were offered a brief individual make-up session if a group session was missed. Sessions focused on improving knowledge related to adoption and maintenance of eating and activity behaviors to promote weight loss, and strategies to facilitate long-term behavior change such as barrier identification, problem solving, mastery experiences for self-efficacy, and others.
The STEP intervention was identical in content to SBWI but contact frequency, contact type, and other weight loss strategies were modified depending on the achievement of specific weight loss goals at 3-month intervals. Weight loss goals were 5% at 3 months, 7% at 6 months, 10% at 9 months, and remained at 10% at 12, 15, and 18 months. While the goal at 9 months and beyond was to achieve a 10% weight loss, participants were encouraged to continue to lose weight if they desired and there were no contraindications to further weight loss. Participants started at Step 1 and progressed to the next Intervention Step only if the weight loss goal was not achieved. Intervention steps are briefly described below and shown in Figure 2.

Jakicic J.M., Tate D.F., Lang W., Davis K.K., Polzien K., Rickman A.D., Erickson K., Neiberg R.H, & Finkelstein E.A. (2012). Effect of a Stepped-Care Intervention Approach on Weight Loss in Adults: The Step-Up Study Randomized Trial. JAMA : the journal of the American Medical Association, 307(24), 2617-2626.

Publication 2012

Diet Dietary Fats Infantile Neuroaxonal Dystrophy

Intragastric Ethanol Feeding in Mice

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Publication 2014

Acclimatization Animal Nutritional Physiological Phenomena Catheters Corn oil Dacron Diet Dietary Carbohydrates Dietary Fats Ethanol Fatty Acids Fatty Acids, Essential Fatty Acids, Monounsaturated Fatty Acids, Unsaturated Feelings Gastrostomy Glucose Glycerides Ketamine Lactalbumin Linoleic Acid Males Mice, House Mice, Inbred C57BL Movement Oleic Acid Ovum Implantation Palmitic Acid Pellets, Drug Polyunsaturated Fatty Acids Proteins Saturated Fatty Acid Silastic Sodium Chloride, Dietary Soybeans stearic acid Sterility, Reproductive Trace Minerals Vitamins Xylazine

Metabolic Abnormalities and Weight Status

A sample of 6,011 adults (age 18–65 years) from the Third National Health and Nutrition Examination Survey (NHANES III) Public Access Mortality Linkage was used. Age, sex, income, ethnicity, smoking status, exercise frequency, dietary fat (>30%), alcohol intake, intentions to lose weight over the last year (yes/no), and self-reported body weight 10 years prior were assessed by questionnaire. BMI cutoffs for normal weight (18.5–25 kg/m²), overweight (25–29.9 kg/m²), and obese (≥30 kg/m²) were used. To increase the sample size (n = 6,011 vs. 3,320), participants with fasting data (≥6 vs. ≥8 h) for at least three of the four MetSyn criteria were included.
Metabolic abnormalities were defined as follows (6 (link),7 (link)): 1) triglycerides ≥1.69 mmol/l or medications; 2) systolic blood pressure ≥130 mmHg, diastolic blood pressure ≥85 mmHg, or medications; 3) glucose ≥5.6 mmol/l or medications; 4) HDL cholesterol <1.04 mmol/l for men and <1.29 mmol/l for women; and 5) homeostasis model assessment (HOMA) ≥2.5 (n = 4,602).
Metabolically normal was defined using three separate definitions: 1) insulin sensitive by HOMA; 2) one or fewer MetSyn criteria; or 3) absence of all MetSyn criteria and IR.

Kuk J.L, & Ardern C.I. (2009). Are Metabolically Normal but Obese Individuals at Lower Risk for All-Cause Mortality?. Diabetes Care, 32(12), 2297-2299.

Publication 2009

Adult Congenital Abnormality Dietary Fats Ethnicity Glucose High Density Lipoprotein Cholesterol Homeostasis Insulin Obesity Pharmaceutical Preparations Pressure, Diastolic Systolic Pressure Triglycerides Woman

Global Dietary Consumption Assessment

Data retrieval followed the 2010 Global Burden of Diseases study’s comparative risk assessment framework,33 collecting quantitative data on consumption in 16 age- and sex-specific subgroups across 21 world regions (see eTable 1 of data supplement) and two time periods (1990 and 2010). Most published or publically available dietary data were limited or not in the relevant format. For 173 surveys, 99 corresponding members provided original raw data to us or re-analysed their raw data according to our specifications, providing age and sex stratified dietary results in specified metrics and units using a standardised electronic format (appendix 1 of data supplement). Optimal and alternative metrics and units were defined for each dietary factor,19 (link) with optimal units matching those of studies used to evaluate relationships with disease risk as well as major dietary guidelines. Based on these criteria, dietary factors were evaluated as percentage energy (saturated fat, omega 6 polyunsaturated fat, trans fat) or as mg/day standardised using the residual method34 to 2000 kcal/day (dietary cholesterol, seafood omega 3 fat, plant omega 3 fat). The surveys providing data on dietary fats and oils are listed in eTable 2 of data supplement.
For each survey, we extracted data on survey characteristics, dietary metrics, units, and mean and distribution (such as standard deviation) of consumption of each dietary fat and oil, by age and sex (eTable 2). Data were double checked for extraction errors and assessed for plausibility. We assessed survey quality by evaluating evidence for selection bias, sample representativeness, response rate, and validity of diet assessment method.19 (link) Measurement comparability across surveys was maximised by using a standardised data analysis approach that (1) accounted for sampling strategies within the survey by including sampling weights (if available), (2) used the average of all days of dietary assessment to quantify mean intakes, (3) used a corrected population standard deviation to account for within person variation versus between person variation, (4) used standardised dietary metrics and units of measure across surveys, and (5) adjusted for total energy to reduce measurement error and account for differences in body size, metabolic efficiency, and physical activity.34

Micha R., Khatibzadeh S., Shi P., Fahimi S., Lim S., Andrews K.G., Engell R.E., Powles J., Ezzati M, & Mozaffarian D. (2014). Global, regional, and national consumption levels of dietary fats and oils in 1990 and 2010: a systematic analysis including 266 country-specific nutrition surveys. The BMJ, 348, g2272.

Publication 2014

Body Size Cholesterol, Dietary Diet Dietary Fats Dietary Supplements Health Risk Assessment Omega-3 Fatty Acids Plants Saturated Fatty Acid Seafood Therapy, Diet

Most recents protocols related to «Dietary Fats»

Comprehensive Weight Loss Intervention

Participants in this group attended the 2-h class described above, received a workbook, completed a “Live” counseling call (31 (link)), and received 22 tailored IVR calls over a period of 12 months with the final 6 months focusing on maintenance and relapse prevention based on DPP's after Core program. This intervention was designed to help participants initiate moderate weight loss through physical activity and healthful eating and maintain these behavior changes. All participants developed a personal action plan with the goal of losing 10% of their current weight in 12 months and being physically active for 60 min a day, 5 days per week. Workbook content topics focused on achieving a balanced diet through the reduction of fat and caloric intake plus adding regular physical activity to enhance initial weight loss and prevent weight regain. Additionally, we used the 5 A's model to assist participants in setting physical activity and healthful eating goals necessary for weight loss and maintenance (32 (link)). One week after class completion, participants received a telephone call lasting 45–60 min to reinforce learning objectives and provide further clarifications (31 (link)). Research assistants delivered this call using teach-to-goal and teach-back strategies to allow participants to describe key intervention concepts (i.e., MyPlate guidelines, types, and length of physical activity) using their own words and provide additional rounds of education until the participant demonstrated a firm understanding of the information. For those participants that did not attend the initial 2-h class, the research assistants provided the full content of the class and assisted them in creating their personal action plan. One week after the live telephone call the participants began receiving IVR support calls. There were 22 IVR calls lasting between 15 and 30 min with 8 weekly calls, followed by 8 biweekly calls and 6 monthly calls focusing on maintenance and relapse prevention. Participants were required to complete one call before moving on to the next call, as such, it was not possible to skip IVR calls and content. For those participants that did not complete an IVR call, reminder contacts using telephone, text, and email were used for up to 2 weeks to try and get participants back on track. Each IVR call included an assessment of current weight, PA, and dietary behaviors, feedback on goal progression, content related to the session topic (i.e., Move Those Muscles, Being Active: A Way of Life, Healthy Eating With MyPlate, Be A Fat Detective), teach to goal reinforcement of key messages, and a homework assignment. New action plans were created every month (Calls 4, 8, 12, and 16) through Call 16 and then on every call during the maintenance and relapse prevention phase. This included updating goals, identifying new barriers, selecting strategies to resolve barriers, and goal setting-feedback loops.

Almeida F.A., You W., Brito F.A., Alves T.F., Goessl C., Wall S.S., Seidel R.W., Davy B.M., Greenawald M.H., Hill J.L, & Estabrooks P.A. (2023). A randomized controlled trial to test the effectiveness of two technology-enhanced diabetes prevention programs in primary care: The DiaBEAT-it study. Frontiers in Public Health, 11, 1000162.

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Publication 2023

Diet Dietary Fats Disease Progression Infantile Neuroaxonal Dystrophy Muscle Tissue Reinforcement, Psychological Relapse Prevention Teaching

Olanzapine Effects on Lipid Metabolism

Olanzapine was purchased from the Tokyo Chemical Industry (Tokyo, Japan). The medium-fat diet (containing 1.37 IU of cholecalciferol/g) and cholecalciferol-supplemented medium-fat diet (containing 200 IU of cholecalciferol/g) were purchased from Oriental Yeast (Tokyo, Japan). Olanzapine was dissolved in water with 0.5% of carboxymethyl cellulose before use. Cholecalciferol is usually administered orally as a chow supplement, and the intake dose may vary slightly among mice. Mice were first randomized into two groups and fed a medium-fat diet or a cholecalciferol-supplemented medium-fat diet for 1 week. Mice from each group were further randomized to be treated with Olanzapine (10 mg/kg, orally administered) or vehicle (0.5% of carboxymethyl cellulose solution) for another 5 days. One day after the last dose of Olanzapine, the mice were anesthetized and dissected for blood collection by cardiac puncture. Mouse serum was isolated from blood samples by centrifugation. Serum total cholesterol levels were measured using a LabAssay Cholesterol kit (Wako, Osaka, Japan), while serum LDL cholesterol, HDL cholesterol, and triglyceride levels were measured by Nagahama Lifescience (Oriental Yeast Co., Ltd., Shiga, Japan).

Zhou Z., Nagashima T., Toda C., Kobayashi M., Suzuki T., Nagayasu K., Shirakawa H., Asai S, & Kaneko S. (2023). Vitamin D supplementation is effective for olanzapine-induced dyslipidemia. Frontiers in Pharmacology, 14, 1135516.

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Publication 2023

Asian Persons BLOOD Carboxymethylcellulose Centrifugation Cholecalciferol Cholesterol Cholesterol, beta-Lipoprotein Dietary Fats Heart High Density Lipoprotein Cholesterol Mice, House Olanzapine Punctures Serum Therapy, Diet Triglycerides Yeast, Dried

Dietary Manipulation of Ube3a Mice

WT, Ube3a^m–/p+ (maternal transmission), and Ube3a^m+/p– (paternal transmission) mice (6-8 weeks old) were pair-fed for 8-12 weeks (before DRG dissection or behavioral experiments) with a: A) standard diet (sd; #7012 ENVIGO; UTHSC animal facility diet; (https://insights.envigo.com/hubfs/resources/data-sheets/7012-datasheet-0915.pdf); B) Safflower oil-supplemented diet (enriched in LA, Dyets # 112245). Modified AIN-93G purified rodent diet with 59% fat derived calories from safflower oil (kcal/kg): Casein (716), L-Cystine (12), Maltose Dextrin (502), Cornstarch (818.76), Safflower Oil (2430), Soybean Oil (630), Mineral Mix (# 210025; 30.8), and Vitamin Mix (#310025; 38.7); C) High-fat diet (anhydrous milk fat supplemented, Dyets # 105012). Modified AIN-93G Purified Rodent Diet with 59% Fat Derived Calories from Anhydrous Milk Fat (kcal/kg): Casein (716), L-Cystine (12), Maltose Dextrin (502), Cornstarch (818.76), Anhydrous Milk Fat (2430), Soybean Oil (630), Mineral Mix (# 210025; 30.8), and Vitamin Mix (#310025; 38.7).

Romero L.O., Caires R., Kaitlyn Victor A., Ramirez J., Sierra-Valdez F.J., Walsh P., Truong V., Lee J., Mayor U., Reiter L.T., Vásquez V, & Cordero-Morales J.F. (2023). Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome. Nature Communications, 14, 1167.

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Publication 2023

Animals Caseins Cornstarch Cystine Dextrin Diet, High-Fat Dietary Fats Dissection Maltose Mice, House Milk, Cow's Minerals Rodent Safflower oil Soybean oil Therapy, Diet Transmission, Communicable Disease Vertical Infection Transmission Vitamins

Personalized Dietary Intervention for Obese Children

A specialized dietitian developed the participants’ diet, prepared the meals, and recorded both the type and weight of the food. During the exercise intervention, daily energy supply according to the Molnár equation (Molnár et al., 1995 (link)) after calculating the resting energy expenditure (REE) of obese children. Dietary caloric supply based on the resting metabolic level. The dietitian matched the diet types according to the Dietary Guidelines for Chinese Residents, in which the ratio of energy supply was 30%:40%:30% for morning, midday, and evening meals; the ratio of caloric distribution of carbohydrates, protein, and fat in the diet was 55%–65%:20%–30%:10%–15%. Mainly, the food types included fresh vegetables, fruits, eggs, meat, and cereals.

Cao Y., Zhu L., Chen Z., Zhanquan L., Xie W, & Liang M. (2023). The effect of different intensity physical activity on cardiovascular metabolic health in obese children and adolescents: An isotemporal substitution model. Frontiers in Physiology, 14, 1041622.

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Publication 2023

Carbohydrates Cereals Child Chinese Diet Dietary Fats Dietitian Eggs Energy Metabolism Food Fruit Meat Obesity Proteins Therapy, Diet Vegetables

Formulating Isonitrogenous and Isolipidic Diets

Four isonitrogenous and isolipidic practical experimental diets were formulated containing 0% phospholipid supplement (control), 2% soybean lecithin (SL), egg yolk lecithin (EL), or krill oil (KO) (dry matter). The ingredients and proximate composition of the four experimental diets are presented in Table 1. Dietary protein sources were mainly consisting of fish meal, soybean meal, and cottonseed meal (approximately 43.5% crude protein). Dietary lipid sources were mainly consisting of soybean oil and cholesterol (crude lipid content is 14.3% approximately). To avoid lipid peroxidation in diets, butylated hydroxytoluene (BHT) were added at the concentration of 0.05‰. Three protein source ingredients were ground and sifted through a 60-mesh sieve (250 μm particle size). All dry dietary ingredients were homogenized finely before liquid oil was added. The configured mixture was passed through a 40-mesh sieve (425 μm particle size). Finally, distilled water was added to the premixture (120 mL/kg dry ingredients). Dietary pellet was carried out to a 2.5 mm diameter by a cold press double helix plodder (CD4 ×1TS, SCUT, Guangdong, China). The scattered pellets were dried in a well-ventilated environment until the moisture was less than 10%. Pellets were labeled and stored in a refrigerator at -20°C.

Xu C., Yang X., Liang Z., Jiang Z., Chen H., Han F., Jia Y, & Li E. (2023). Evaluation of the Role of Soybean Lecithin, Egg Yolk Lecithin, and Krill Oil in Promoting Ovarian Development in the Female Redclaw Crayfish Cherax quadricarinatus. Aquaculture Nutrition, 2023, 6925320.

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Publication 2023

Cholesterol Cold Temperature Diet Dietary Fats Dietary Proteins Dietary Supplements Euphausiacea Fishes Helix (Snails) Lecithin Lipid Peroxidation Lipids Pellets, Drug Phospholipids Proteins Soybean Flour Soybean oil Soybeans Yolks, Egg

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More about "Dietary Fats"

Dietary lipids, fatty acids, triglycerides, cholesterol, nutrition, metabolism, cardiovascular health, metabolic processes, energy, fat-soluble vitamins, cell membranes, saturated fats, monounsaturated fats, polyunsaturated fats, D12492, D12451, C57BL/6J mice, C57BL/6 mice, SAS 9.4, HFD, C57BL/6J, STZ, C57BL/6 male mice, research optimization, reproducibility, accuracy, PubCompare.ai.