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> Phenomena > Phenomenon or Process > Inotropism

Inotropism

Inotropism refers to the influence on the force or energy of muscular contraction, particularly of the heart.
This term encompasses both positive inotropic effects, which increase contractile force, and negative inotropic effects, which decrease contractile force.
Factors that can influence inotropism include drugs, hormones, and various physiological and pathological conditions.
Understanding inotropism is crucial for the study and treatment of cardiovascular disorders, as it plays a key role in cardiac function and performance.
PubCompare.ai's AI-driven platform can optimize inotropsm research by helping users find the best protocols and products, comparing data from literature, pre-prints, and patents to enhance reproducibility and accuracy, empowering researchers to make informed decisions.

Most cited protocols related to «Inotropism»

1
Vasoactive Medication Dosing and Clinical Outcomes
Our analytic methods mirror those of our original publication. [6 (link)] Doses of vasoactive medications were recorded hourly for the first 48 hours after post-operative admission to the CICU. The full list of medications can be viewed in Appendix 1. We calculated the Inotrope Score (IS) and the Vasoactive-Inotropic Score (VIS) as described previously [6 (link)] and as shown in Box 1.
We also assessed the sensitivity and specificity of a score including all inotropes, vasopressors, and vasodilators listed in Appendix 1. This formula was inferior to the IS and VIS, and was not further analyzed.
We calculated the maximum and mean IS and VIS in the first and second 24 hour periods after admission to the CICU. To account for vasoactive support over time, and for cases where a patient returned to the CICU on high support only to have it quickly weaned, we studied the mean IS/VIS. Mean IS/VIS was calculated by summing the hourly doses during the 24 hours period and dividing by 24. We also used the IS and VIS at hour 2 and compared this to the other measures. Patients were classified into one of the 5 mutually exclusive groups defined in our previous study [6 (link)] based on their scores at the different time points (Table 1), and assigned to the highest group achieved in either frame. For patients who reached a clinical endpoint (see next section below) in the first 48 hours, we did not use any IS or VIS scores after the event to calculate their maximum and mean scores or to classify them into the group framework. We chose to do this because we were interested in using VIS as a metric to predict eventual clinical outcome, and scores collected after an event (e.g. cardiac arrest or initiation of mechanical circulatory support) do not contribute meaningful data for that purpose.
Gaies M.G., Jeffries H.E., Niebler R.A., Pasquali S.K., Donohue J.E., Yu S., Gall C., Rice T.B, & Thiagarajan R.R. (2014). Vasoactive-Inotropic Score (VIS) is Associated with Outcome After Infant Cardiac Surgery: An Analysis from the Pediatric Cardiac Critical Care Consortium (PC4) and Virtual PICU System Registries. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 15(6), 529-537.
Publication 2014
Cardiac Arrest Cardiovascular System Inotropism Patients Pharmaceutical Preparations Reading Frames Vasoconstrictor Agents Vasodilator Agents
2
Therapeutic Hypothermia Post-Cardiac Arrest

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Publication 2008
Acute Coronary Syndrome Angina Pectoris Benzodiazepines Cardiac Arrest Cardiac Arrhythmia Care, Comfort Catheterizations, Cardiac Catheters Chest Cognitive Training Comatose Consciousness Echocardiography Electric Countershock Esophagus Gastric Lavage Glycemic Control Implantable Defibrillator Injuries Inotropism Insulin Intracranial Hemorrhage Intravenous Infusion Left Bundle-Branch Block Neurologic Examination Operative Surgical Procedures Patients physiology Propofol Pulmonary Artery Rectum Saline Solution Sedatives Seizures Urinary Bladder Urine Vasoconstrictor Agents
3
Assisted Ventilation in Acute Respiratory Failure
Patients admitted over a period of one year (from May 2013 to May 2014) to the ICU of the University of Bari Academic Hospital were considered for enrollment in the study. The local ethics committee (Azienda Ospedaliero-Universitaria Policlinico di Bari Ethic Committee, protocol number: 257/C.E. March 2013) approved the investigative protocol, and written informed consent was obtained from each patient or next of kin. A physician not involved in the study was always present for patient care. Our clinical trial was registered with clinicalTrials.gov, identifier: NCT02473172.
Patients were eligible for the study if they were older than 18 years, oro-tracheally or naso-tracheally intubated, had been ventilated for acute respiratory failure with CMV (flow-limited, pressure-limited or volume-targeted pressure-limited) for at least 72 hours consecutively and were candidates for assisted ventilation. The criteria for defining the readiness to assisted ventilation were: a) improvement of the condition leading to acute respiratory failure; b) positive end-expiratory pressure (PEEP) lower than 10 cmH2O and inspiratory oxygen fraction (FiO2) lower than 0,5; c) Richmond agitation sedation scale (RASS) score between 0 and –1 [23 (link)] obtained with no or moderate levels of sedation and, d) ability to trigger the ventilator, i.e., to decrease pressure airway opening (PAO) >3–4 cmH2O during a brief (5–10 s) end-expiratory occlusion test. Other criteria included hemodynamic stability without vasopressor or inotropes (excluding a dobutamine and dopamine infusion <5 gamma/Kg/min and 3 gamma/Kg/min, respectively) and normothermia. Patients were excluded from the study if they were affected by neurological or neuromuscular pathology and/or known phrenic nerve dysfunction, or if they had any contraindication to the insertion of a nasogastric tube (for example: recent upper gastrointestinal surgery, esophageal varices).
Di mussi R., Spadaro S., Mirabella L., Volta C.A., Serio G., Staffieri F., Dambrosio M., Cinnella G., Bruno F, & Grasso S. (2016). Impact of prolonged assisted ventilation on diaphragmatic efficiency: NAVA versus PSV. Critical Care, 20, 1.
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Publication 2016
Conscious Sedation Dental Occlusion Dobutamine Dopamine Esophageal Varices Ethics Committees Exhaling Gamma Rays Gastrointestinal Surgical Procedure Hemodynamics Inhalation Inotropism Intubation, Nasogastric Oxygen Patients Phrenic Nerve Physicians Positive End-Expiratory Pressure Precipitating Factors Pressure Regional Ethics Committees Respiratory Failure Sedatives Vasoconstrictor Agents
4
Adrenal Function Assessment in ICU Patients
At study entry, the following parameters were recorded: time from ICU admission, age and sex, and ICD-10 diagnoses of common clinical conditions at admission. At the day of each ACTH test, the following were collected: serum total and free cortisol levels before and 30 and 60 minutes after 250 μg of i.v. ACTH, serum levels of ACTH cortisol-binding globulin (CBG), and albumin. Other laboratory measurements included total white blood cell count, platelet count, activated partial thromboplastin time (aPTT), and prothrombin time (PT). Interventions including type and doses of vasopressor/inotropes, intubation, need for mechanical ventilation, and renal replacement therapy were recorded. Sepsis was defined as the presence of systemic inflammatory response syndrome (SIRS) with a positive microbiologic local (urine, trachea, or other) and/or blood culture. SIRS was defined as two or more of the following criteria: a temperature of >38°C or <35.5°C, a leukocyte count >12 of <4 × 109/L, a heart rate >90 per minute, and a respiratory rate >20 per minute, or the presence of mechanical ventilation. Suspected or microbiologically proven sources of sepsis were recorded. Disease severity was assessed by the acute physiology and chronic health evaluation score (APACHE II) and sequential organ-failure assessment score (SOFA) on the days of the ACTH test, and length of ICU stay and mortality in the ICU and hospital were recorded.
de Jong M.F., Molenaar N., Beishuizen A, & Groeneveld A.J. (2015). Diminished adrenal sensitivity to endogenous and exogenous adrenocorticotropic hormone in critical illness: a prospective cohort study. Critical Care, 19(1), 1.
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Publication 2015
Activated Partial Thromboplastin Time Albumins Blood Culture cortisol binding globulin Diagnosis Hydrocortisone Inotropism Intubation Leukocyte Count Mechanical Ventilation physiology Platelet Counts, Blood Rate, Heart Renal Replacement Therapy Respiratory Rate Septicemia Serum Systemic Inflammatory Response Syndrome Times, Prothrombin Trachea Training Programs Urine Vasoconstrictor Agents
5
Anticoagulation in Severe COVID-19
All three platforms enrolled patients who were hospitalized for Covid-19. Although REMAP-CAP enrolled patients with suspected or confirmed Covid-19, only patients with infection confirmed by laboratory testing were included in the primary analysis of the multiplatform trial. The trial was designed to evaluate the effect of therapeutic-dose anticoagulation in patients with severe Covid-19 and in those with moderate Covid-19 stratified according to d-dimer level (high, low, or unknown). This report describes the results of the analyses involving patients with severe Covid-19; the results of analyses involving patients with moderate Covid-19 are reported separately.17 (link)Severe Covid-19 was defined as Covid-19 that led to receipt of ICU-level respiratory or cardiovascular organ support (oxygen through a high-flow nasal cannula, noninvasive or invasive mechanical ventilation, extracorporeal life support, vasopressors, or inotropes) in an ICU. In ACTIV-4a, in which definitions of an ICU were thought to be challenging to operationalize during the pandemic, receipt of ICU-level organ support, irrespective of hospital setting, was used to define ICU-level care. Patients were ineligible if they had been admitted to the ICU with Covid-19 for 48 hours or longer (in REMAP-CAP) or to a hospital for 72 hours or longer (in ACTIV-4a and ATTACC) before randomization. They were also ineligible if they were at imminent risk for death and there was no ongoing commitment to full organ support, or if they were at high risk for bleeding, were receiving dual antiplatelet therapy, had a separate clinical indication for therapeutic-dose anticoagulation, or had a history of heparin sensitivity, including heparin-induced thrombocytopenia. Detailed exclusion criteria for the platforms are provided in the Supplementary Appendix.
Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. (2021). The New England Journal of Medicine.
Publication 2021
Cardiovascular System COVID 19 Dual Anti-Platelet Therapy Extracorporeal Membrane Oxygenation Heparin Hypersensitivity Infection Inotropism Mechanical Ventilation Nasal Cannula Oxygen Pandemics Patients Respiratory Rate Therapeutic Effect Therapeutics Thrombocytopenia Vasoconstrictor Agents

Most recents protocols related to «Inotropism»

1
Diabetes Management in Cardiac Surgery
The present study was a randomized control trial following CONsolidated Standards of Reporting Trials (CONSORT) guideline. After institutional review board (IRB) approval (November 19, 2019), the trial was conducted in DM patients who were set for cardiac surgery undergoing cardiopulmonary bypass (CPB) at the Cardiac Center, King Chulalongkorn Memorial Hospital. Inclusion criteria were 20–80 years of age, DM Type 2 (T2DM), and scheduling for elective valvular heart surgery (VHS) or coronary artery bypass graft (CABG). Exclusion criteria were 1) DM Type 1, 2) insulin-dependent T2DM, 3) BG <60 or >300 mg/dL from 6 pm of the day before surgery, 4) preoperative administration of insulin, glucose, or dextrose solution, 5) preoperative inotropes/vasopressors infusion or mechanical cardiovascular support devices, 6) history of postoperative nausea or vomiting (PONV), 7) thyroid cancer or endocrine neoplasia syndromes, 8) chronic pancreatitis or previous surgery of pancreas, 9) recent steroid administration, 10) pregnancy, and 11) current treatment with GLP-1 analogs. Written informed consent was obtained from all the enrolled samples.
Sindhvananda W., Poopuangpairoj W., Jaiprasat T, & Ongcharit P. (2023). Comparison of Glucose Control by Added Liraglutide to Only Insulin Infusion in Diabetic Patient Undergoing Cardiac Surgery: A Preliminary Randomized-Controlled Trial. Annals of Cardiac Anaesthesia, 26(1), 63-71.
Publication 2023
Carcinoma, Thyroid Cardiopulmonary Bypass Cardiovascular System Coronary Artery Bypass Surgery Elective Surgical Procedures Endocrine Gland Neoplasms Ethics Committees, Research Glucagon-Like Peptide 1 Glucose Heart Heart Valves Inotropism Insulin Medical Devices Operative Surgical Procedures Pancreas Pancreatitis, Chronic Patients Pregnancy Steroids Surgical Procedure, Cardiac Syndrome Vasoconstrictor Agents
2
Cardiovascular Procedure Risk Factors
Preoperative factors were collected, including age, sex, recent major cardiovascular procedure (within 3 months), coronary artery disease, cerebral vascular events, chronic lung disease, essential hypertension, dyslipidemia, liver cirrhosis, atrial fibrillation, type 2 diabetes mellitus, end-stage renal disease with dialysis (both hemodialysis and peritoneal dialysis), and regular use of antiplatelet or anticoagulant agents. The major cardiovascular procedures included coronary arterial bypass, coronary arterial angioplasty/stenting, cardiac valvular surgery, aortic surgery, and peripheral arterial surgery. Preoperative blood cell counts included white cell counts, differential counts (immature band form white cell) [15 (link)], platelet counts, the neutrophil-to-lymphocyte ratio (NLR) [16 (link)], and hemoglobin levels. Preoperative blood biochemistry results included serum levels of albumin, alanine aminotransferase (ALT), bilirubin, and creatinine. The coagulation test included the prothrombin time (PT) and was expressed by the international normalized ratio (INR). Preoperative shock status was defined as the requirement for vasopressors or inotropes. The types of AMI were determined by preoperative contrast CT scans.
Liu H.T., Lai C.Y., Liao J.J., Chen Y.J., Cheng S.B, & Wu C.C. (2023). Immediate postoperative parenteral anticoagulant therapy in patients with mesenteric ischemia after intestinal resection: a retrospective cohort study at a single institute. BMC Gastroenterology, 23, 56.
Full text: Click here
Publication 2023
Angioplasty Angioplasty, Balloon, Coronary Anticoagulants Aorta Arteries Artery, Coronary Atrial Fibrillation Bilirubin BLOOD Cardiovascular System Cells Cerebrovascular Accident Coronary Arteriosclerosis Coronary Artery Bypass Surgery Creatinine D-Alanine Transaminase Diabetes Mellitus, Non-Insulin-Dependent Dialysis Disease, Chronic Dyslipidemias Essential Hypertension Hemodialysis Hemoglobin Inotropism International Normalized Ratio Kidney Failure, Chronic Leukocyte Count Liver Cirrhosis Lung Lung Diseases Lymphocyte Neutrophil Neutrophil Band Cells Operative Surgical Procedures Peritoneal Dialysis Platelet Counts, Blood Serum Albumin Shock Surgical Procedure, Cardiac Tests, Blood Coagulation Times, Prothrombin Vasoconstrictor Agents X-Ray Computed Tomography
3
Heart Failure Patients in Abu Dhabi
The study was conducted in a tertiary hospital, designated as the National Center for Excellence in Cardiology in Abu Dhabi. The hospital is composed of over 730-bed capacity. Patients who were admitted with a medical diagnosis of HF were included in the study. These patients were purposively selected based on their willingness to participate, ability to read and write either Arabic or English and having N-terminal pro b-type natriuretic peptide (NT-pro-BNP) level of >400 pg/ml.
However, patients with known psychiatric or cognitive impairments, cardiogenic shock (any circulation support drug or devices such as intra-aortic balloon pump/inotropes), those who could not independently perform basic self-care activities (checking and recording weight) were excluded.
Roussia S., Muthu P, & Ilesanmi R.E. (2023). Self-care Management in Heart Failure Using Roy Adaptation Theory-guided Intervention in the United Arab Emirates. SAGE Open Nursing, 9, 23779608231160484.
Publication 2023
Cardiovascular System Diagnosis Disorders, Cognitive Inotropism Intra-Aortic Balloon Pumping Medical Devices Patients Pharmaceutical Preparations pro-brain natriuretic peptide (1-76) Shock, Cardiogenic
4
Neonatal Morbidities and Neuroimaging Outcomes
Maternal and neonatal data were abstracted from electronic medical records and charts. Antenatal and perinatal data: maternal age, medical conditions, place of birth, corticosteroids administration, mode of delivery, GA at birth, birth weight, sex, delayed cord clamping, invasive ventilation at birth, cord pH, Apgar score at 1 and 5 min.
Prematurity-related clinical morbidities: patent ductus arteriosus (PDA) requiring treatment, sepsis, hypotension requiring inotropes, bronchopulmonary dysplasia (the need for supplemental oxygen at 36 weeks' postmenstrual age), periventricular leukomalacia (PVL).
Ventricular measurements and fNIRS data: 2D cUS GMH-IVH staging (right, left), 3D cUS ventricle volumes (left, right and total), postnatal course during each measurement and resting state fNIRS data. For infants with PHVD, before and after each CSF diversion procedure: head circumference, weight, hemoglobin, respiratory support, tap volume, the need for VP shunt and brain MRI for those infants who went on to have one.
Kebaya L.M., Stubbs K., Lo M., Al-Saoud S., Karat B., St Lawrence K., de Ribaupierre S, & Duerden E.G. (2023). Three-dimensional cranial ultrasound and functional near-infrared spectroscopy for bedside monitoring of intraventricular hemorrhage in preterm neonates. Scientific Reports, 13, 3730.
Full text: Click here
Publication 2023
Adrenal Cortex Hormones Apgar Score Birth Weight Brain Bronchopulmonary Dysplasia Cerebral Ventricles Childbirth Cone-Rod Dystrophy 2 Head Heart Ventricle Hemoglobin Infant Infant, Newborn Inotropism Leukomalacia, Periventricular Mothers Obstetric Delivery Oxygen Patent Ductus Arteriosus Premature Birth Respiratory Rate Septicemia
5
Antimicrobial Stewardship and End-of-Life Care
All the antimicrobial agents were included in the analysis. Patients receiving topical, ophthalmic, or otic antibiotics were excluded from the study. The amount of antimicrobial agents was measured by the days of therapy (DOT) and standardized for 1,000 patient-days. The Life-Sustaining Treatment Decision Act makes withholding and withdrawing LST possible using the legal determination form.20 This legal determination form is intended for patients with “serious chronic or acute illness nearing the end stages or likely to progress to a life-threatening state suddenly”. LST was defined as CPR, MV support, renal replacement therapy, chemotherapy, extracorporeal membrane oxygenation, transfusion, and use of inotropes. The form can be completed by any patient at any time or by the patient’s relative according to the Act. The completion of the LST form was divided into an LST form completed ≤ 14 days prior to death and an LST form completed > 14 days prior to death. ID specialists in each participating hospital assessed the antibiotic prescription as needing escalation, de-escalation, continuing, discontinuing or not assessable. Cases assessed as “Needing to continue” were considered appropriate antibiotic prescriptions, and other assessments were classified as inappropriate antibiotic prescriptions. Multidrug resistant (MDR) organisms include multidrug-resistant Acinetobacter baumannii (MRAB), vancomycin-resistant enterococci, methicillin-resistant Staphylococcus aureus, multidrug-resistant Pseudomonas aeruginosa (MRPA), and carbapenem-resistant Enterobacteriaceae (CRE).
Wi Y.M., Kwon K.T., Hwang S., Bae S., Kim Y., Chang H.H., Kim S.W., Cheong H.S., Lee S., Jung D.S., Sohn K.M., Moon C., Heo S.T., Kim B., Lee M.S., Hur J., Kim J, & Yoon Y.K. (2023). Use of Antibiotics Within the Last 14 Days of Life in Korean Patients: A Nationwide Study. Journal of Korean Medical Science, 38(9), e66.
Publication 2023
Acinetobacter baumannii Antibiotics Antibiotics, Antitubercular Blood Transfusion Carbapenem-Resistant Enterobacteriaceae Ear Extracorporeal Membrane Oxygenation Eye Inappropriate Prescriptions Inotropism Methicillin-Resistant Staphylococcus aureus Microbicides Patients Pharmacotherapy Prescriptions Pseudomonas aeruginosa Renal Replacement Therapy Specialists Vancomycin-Resistant Enterococci

Top products related to «Inotropism»

1
Voluven by Fresenius
Sourced in Germany, Sweden, France
Voluven is a colloid solution that is used to replace or maintain blood volume. It contains hydroxyethyl starch, which helps to maintain fluid balance in the body.
2
Lactate pro 2 by Arkray
Sourced in Japan, United States
The Lactate Pro 2 is a portable, handheld lactate analyzer designed for rapid measurement of lactate levels in blood samples. It provides accurate and reliable results within a short timeframe.
3
Statistical analysis system version 9 by SAS Institute
Sourced in United States, Germany
Statistical Analysis System (SAS) version 9.4 is a software package developed by SAS Institute for advanced analytics, business intelligence, and data management. It provides a comprehensive set of tools for statistical analysis, data manipulation, and reporting. SAS 9.4 is designed to handle large and complex data sets, offering capabilities in areas such as regression analysis, multivariate techniques, time series analysis, and more. The software is primarily used by researchers, analysts, and organizations in various industries to gain insights from their data.
4
Cardiohelp system by Getinge
Sourced in Germany, Sweden
The Cardiohelp system is a portable, extracorporeal life support device designed for temporary cardiac and/or respiratory assistance. It provides advanced life support capabilities to clinicians.
5
Pulmonary artery catheter by Edwards Lifesciences
Sourced in United States
The Pulmonary Artery Catheter is a medical device designed to measure various hemodynamic parameters, including cardiac output, central venous pressure, and pulmonary artery pressure. It is commonly used in critical care and surgical settings to monitor and manage the patient's cardiovascular function.
6
Sas 9 by SAS Institute
Sourced in United States, Austria, Japan, Belgium, United Kingdom, Cameroon, China, Denmark, Canada, Israel, New Caledonia, Germany, Poland, India, France, Ireland, Australia
SAS 9.4 is an integrated software suite for advanced analytics, data management, and business intelligence. It provides a comprehensive platform for data analysis, modeling, and reporting. SAS 9.4 offers a wide range of capabilities, including data manipulation, statistical analysis, predictive modeling, and visual data exploration.
7
Hls module advanced by Getinge
Sourced in Germany
The HLS Module Advanced is a versatile piece of lab equipment designed for high-level sterilization and decontamination. It functions as a crucial component in the laboratory setting, providing a reliable solution for the sterilization of various materials and equipment.
8
Nicoletone veeg system by Natus
The NicoletOne™ vEEG system is a video electroencephalography (vEEG) device designed for clinical use. It provides continuous monitoring and recording of brain electrical activity and associated video data.
9
Spss statistics version 21 by IBM
Sourced in United States, Japan, United Kingdom, Germany, Belgium, China
SPSS Statistics version 21 is a statistical software package developed by IBM. It is designed for data analysis and management, providing tools for data exploration, modeling, and reporting. The software offers a range of statistical techniques and is widely used in academic and professional research settings.
10
Chart software by ADInstruments
Sourced in Germany, United States, Australia, United Kingdom
The Chart software is a data analysis and visualization tool developed by ADInstruments. It is designed to acquire, analyze, and present data from various scientific and research experiments. The software provides a user-friendly interface for recording, displaying, and processing data in real-time.

More about "Inotropism"

Inotropism, also known as contractility or inotropy, refers to the influence on the force or energy of muscular contraction, particularly of the cardiac muscle.
This physiological process encompasses both positive inotropic effects, which increase contractile force, and negative inotropic effects, which decrease contractile force.
Factors that can influence inotropism include drugs (e.g., cardiac glycosides, beta-adrenergic agonists), hormones (e.g., catecholamines, thyroid hormones), and various physiological and pathological conditions (e.g., exercise, heart failure, sepsis).
Understanding inotropism is crucial for the study and treatment of cardiovascular disorders, as it plays a key role in cardiac function and performance.
Researchers investigating inotropism may utilize various tools and technologies, such as the Voluven fluid management system, Lactate Pro 2 portable lactate analyzer, Statistical Analysis System (SAS) version 9.4 for data analysis, and the Cardiohelp system for extracorporeal life support.
Monitoring devices like the pulmonary artery catheter and the NicoletOne™ vEEG system can also provide valuable insights into cardiac and neurological function.
To optimize inotropism research, researchers can leverage the AI-driven platform provided by PubCompare.ai.
This platform helps users find the best protocols and products by comparing data from literature, pre-prints, and patents, enhancing reproducibility and accuracy.
Additionally, tools like SPSS Statistics version 21 and Chart software can be used for statistical analysis and data visualization, respectively, to support informed decision-making in inotropism studies.
By understanding the various aspects of inotropism and utilizing the appropriate tools and technologies, researchers can advance the understanding and treatment of cardiovascular disorders, ultimately improving patient outcomes.